Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpoly-purine tract binding

PABPN1L KHDRBS1 ATXN1

1.15e-0537243GO:0070717
GeneOntologyMolecularFunctionsingle-stranded RNA binding

PABPN1L KHDRBS1 ATXN1

3.11e-04111243GO:0003727
GeneOntologyMolecularFunctionpoly(A) binding

PABPN1L KHDRBS1

5.51e-0429242GO:0008143
GeneOntologyMolecularFunctionpoly(U) RNA binding

KHDRBS1 ATXN1

7.59e-0434242GO:0008266
GeneOntologyMolecularFunctionpoly-pyrimidine tract binding

KHDRBS1 ATXN1

9.98e-0439242GO:0008187
GeneOntologyBiologicalProcessregulation of glycogen (starch) synthase activity

EPM2A ADIPOQ

3.62e-058242GO:2000465
HumanPhenoUpgaze palsy

KCNC3 ATXN1

1.05e-041462HP:0025331
DomainRRM_1

CSTF2 RBM15 SFPQ PABPN1L

1.33e-04208244PF00076
DomainRRM

CSTF2 RBM15 SFPQ PABPN1L

1.57e-04217244SM00360
DomainRRM_dom

CSTF2 RBM15 SFPQ PABPN1L

1.87e-04227244IPR000504
DomainRRM

CSTF2 RBM15 SFPQ PABPN1L

1.96e-04230244PS50102
Domain-

CSTF2 RBM15 SFPQ PABPN1L

2.46e-042442443.30.70.330
DomainNucleotide-bd_a/b_plait

CSTF2 RBM15 SFPQ PABPN1L

3.04e-04258244IPR012677
DomainGPCR_2-like

ADGRB2 FZD8

2.68e-0360242IPR017981
DomainGPCR_2_secretin-like

ADGRB2 FZD8

2.68e-0360242IPR000832
DomainG_PROTEIN_RECEP_F2_4

ADGRB2 FZD8

2.77e-0361242PS50261
PathwayREACTOME_PTK6_REGULATES_PROTEINS_INVOLVED_IN_RNA_PROCESSING

SFPQ KHDRBS1

1.21e-055162M27731
PathwayREACTOME_PTK6_REGULATES_PROTEINS_INVOLVED_IN_RNA_PROCESSING

SFPQ KHDRBS1

1.21e-055162MM15481
PathwayWP_13Q1212_COPY_NUMBER_VARIATION

ADIPOQ ATXN1

6.63e-0434162M48103
Pubmed

Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia.

SFPQ KHDRBS1

7.43e-06625226766589
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

LZTS2 MAP1A NCKAP5L ATXN1

8.79e-0618425432908313
Pubmed

Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production.

CSTF2 RBM15 SFPQ KHDRBS1

1.37e-0520625422174317
Pubmed

A human MAP kinase interactome.

SFPQ KHDRBS1 MAP1A NCKAP5L ATXN1

2.20e-0548625520936779
Pubmed

Dual-specificity phosphatase 18 modulates the SUMOylation and aggregation of Ataxin-1.

EPM2A ATXN1

2.22e-051025229852174
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

CSTF2 RBM15 SFPQ LZTS2 KHDRBS1 NCKAP5L

3.93e-0592225627609421
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

ADGRB2 SFPQ LZTS2 KHDRBS1 ATXN1

4.33e-0556025521653829
Pubmed

Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families.

KCNC3 ATXN1

6.70e-051725215148151
Pubmed

Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.

RBM15 SFPQ KHDRBS1

7.48e-0511425331553912
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

CSTF2 RBM15 INTS5 SFPQ KHDRBS1 MAP1A

9.53e-05108225638697112
Pubmed

DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.

CEP126 MAP1A

1.14e-042225212812986
Pubmed

Proteomic analysis of the cullin 4B interactome using proximity-dependent biotinylation in living cells.

CSTF2 SFPQ KHDRBS1

1.79e-0415325328225217
Pubmed

Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

SFPQ KHDRBS1

2.13e-043025215782174
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

CSTF2 RBM15 SFPQ KHDRBS1 PRR3

2.40e-0480725522681889
Pubmed

Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.

CSTF2 SFPQ KHDRBS1

2.44e-0417025316159877
Pubmed

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.

SFPQ CAMKK2 KHDRBS1 SLC30A1

3.72e-0448425431995728
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

RBM15 INTS5 CAMKK2 MAP1A

4.08e-0449625431343991
Pubmed

Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation.

KCNC3 ATXN1

5.04e-044625234815492
Pubmed

Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.

CSTF2 SFPQ LZTS2

5.18e-0422025324550385
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

INTS5 CAMKK2 CEP126 LZTS2

5.19e-0452925414621295
Pubmed

Comprehensive interactome of Otx2 in the adult mouse neural retina.

SFPQ KHDRBS1

6.68e-045325226426291
GeneFamilyRNA binding motif containing

CSTF2 RBM15 SFPQ PABPN1L

3.95e-05213174725
ToppCell(05)_Ciliated-(2)_48hpi|(05)_Ciliated / shred by cell type and Timepoint

RBM15 ADIPOQ KCNC3

4.50e-05124253fc8cce8c1809edafbc4e69e501dd4f016f5dfc0b
ToppCellCiliated_cells-A-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

CEP126 MAP1A CATSPERD

1.05e-041652530ebdbbdb151fb797335013d5838af1c7bbc45b06
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

FZD8 INTS5 CEP126

1.07e-04166253f62db9d9b6c9dd8f2afcaea0fc5f8c69f50205b2
ToppCellmetastatic_Brain-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

RBM15 CEP126 MAP1A

1.11e-041682534bf3f85aac4b335efa93d22c9ce7b153cb5ce152
ToppCellICU-NoSEP-Lymphocyte-B-B_intermediate|ICU-NoSEP / Disease, Lineage and Cell Type

ADIPOQ BCAS4 HOXA2

1.17e-04171253c6b8578577aef4fe79c1a8ca778a068052f2c9d4
ToppCellCiliated_cells-A-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

CEP126 MAP1A CATSPERD

1.34e-041792530e6c22de2e3fb0ff23b3301863cf4011c5c59dff
ToppCellCiliated_cells-B-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

CEP126 MAP1A CATSPERD

1.36e-04180253bdea5ec6b60fc8c7cce4d71db5da74ac8675e211
ToppCellCiliated_cells-B-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

CEP126 MAP1A CATSPERD

1.40e-04182253e93968f800bfeb258e4e834fc8bf92d1cb72cd73
ToppCellCiliated_cells-A-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

CEP126 MAP1A CATSPERD

1.45e-0418425307c5a9633ccdcd18771e3230d6198a55c400afa6
ToppCellCiliated_cells-B-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

CEP126 MAP1A CATSPERD

1.47e-04185253f012c243343e1d1956db19b34d062e9b13de2b2a
ToppCellCiliated_cells-A-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

CEP126 MAP1A CATSPERD

1.47e-04185253d77ca57b02125a3a57a37f4aed20c89803b7d551
ToppCelltumor_Lung-Epithelial_cells-tS3|Epithelial_cells / Location, Cell class and cell subclass

CEP126 MAP1A CATSPERD

1.52e-041872533cea677279e71fdb9879530dea10a5e6393beacd
ToppCellCiliated_cells-B-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

CEP126 MAP1A CATSPERD

1.52e-041872532b4262c2e7c7830a976be168cee6eeb738d4feda
ToppCellCiliated_cells-B-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

CEP126 MAP1A CATSPERD

1.52e-041872536fa38dbccca36bc7a4fef46de74c6688f599f421
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CEP126 MAP1A CATSPERD

1.54e-04188253da59b5c0a4b11690a39a964c1a0a83e66aa0972b
ToppCell21-Trachea-Epithelial-Multiciliated_cell|Trachea / Age, Tissue, Lineage and Cell class

CEP126 MAP1A CATSPERD

1.54e-04188253803bf76a85b3033d2a04b08dd2c03ce9c15529ba
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CEP126 MAP1A CATSPERD

1.54e-0418825382c006f43c93f4a867953a446864f02b44536a23
ToppCellCiliated_cells-B-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

CEP126 MAP1A CATSPERD

1.54e-04188253606907c865bd2f11bb6474932716550f7723d858
ToppCellCiliated_cells-A|World / lung cells shred on cell class, cell subclass, sample id

CEP126 MAP1A CATSPERD

1.59e-04190253cd87731aaa7d252424f79cfce9f7931457f17bdf
ToppCellEpithelial_cells-Ciliated_cells-B|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

CEP126 MAP1A CATSPERD

1.59e-04190253426a4806f6e39d4d57c6746609d30bb3ca62df7d
ToppCellCiliated_cells-B|World / lung cells shred on cell class, cell subclass, sample id

CEP126 MAP1A CATSPERD

1.59e-041902537031fbedc13be1a00f6333ad6d51849c3739c2e6
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

CEP126 MAP1A CATSPERD

1.59e-04190253a90a38fccdbf75a286b4d258fc54920c02b282f7
ToppCellEpithelial_cells-Ciliated_cells-A|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

CEP126 MAP1A CATSPERD

1.59e-04190253549d813a8f23b175875e53347928941f143e236c
ToppCell356C-Epithelial_cells-Epithelial-F_(Ciliated)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CEP126 MAP1A CATSPERD

1.62e-041912536d2cf41ee946137c039ddcc13593fc3f670afbba
ToppCell356C-Epithelial_cells-Epithelial-F_(Ciliated)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CEP126 MAP1A CATSPERD

1.62e-04191253dad675251e129254955eac179c84a641a4864586
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

CEP126 MAP1A CATSPERD

1.64e-04192253be592e661367affced9ebe80849b466e6adb3a34
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

CEP126 MAP1A CATSPERD

1.67e-041932530b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCellLAM-Epithelial-AirwayEpi|Epithelial / Condition, Lineage and Cell class

CEP126 MAP1A CATSPERD

1.67e-04193253f2672d2c495ee12c3b7d132452bde581fa5a7856
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CEP126 MAP1A CATSPERD

1.72e-04195253129ad5f4253ecb1a8477cc38773e6e91ea9570b0
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CEP126 MAP1A CATSPERD

1.72e-041952533e70ee987d66d450062d5df3d7c733ccc7344470
ToppCellnormal_Lung-Epithelial_cells-Ciliated|Epithelial_cells / Location, Cell class and cell subclass

CEP126 MAP1A CATSPERD

1.72e-04195253a3e2999fdd4c3575add6e28ecfd1d6606a61f992
ToppCellBL-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CEP126 MAP1A CATSPERD

1.72e-0419525307a6bcef6af93ed87df455dee624037cb75e011a
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CEP126 MAP1A CATSPERD

1.72e-04195253649fd2336e963f6a150d182a53ad5dd838ca80b1
ToppCellNS-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CEP126 MAP1A CATSPERD

1.72e-0419525334e37cff4849696ca4ba5dd8fd2cf98fed8bc912
ToppCellCOVID-19-Epithelial-Ciliated_cells|Epithelial / Condition, Lineage and Cell class

CEP126 MAP1A CATSPERD

1.74e-04196253de7aa31354b019d7321a8ef965d59ce2e8b89276
ToppCellNS-moderate-d_07-13-Epithelial-Ciliated-diff|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CEP126 MAP1A CATSPERD

1.74e-041962539a91a6e5f93ce3bb5a0fc63677553f4c2df95c43
ToppCellPSB-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CEP126 MAP1A CATSPERD

1.77e-041972536865f4831eb23794fb88a8649d48d497bbae3f44
ToppCelldistal-Epithelial-Ciliated-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CEP126 MAP1A CATSPERD

1.80e-04198253d30d6c6a0a78b7571318b5b2a0186df96dd0f5a9
Diseaseejection fraction measurement

LZTS2 ATXN1

6.09e-0443252EFO_0005527

Protein segments in the cluster

PeptideGeneStartEntry
GRGPGTVPPGPGHSH

ADGRB2

786

O60241
HRGGRRGPGPAGAGP

EPM2A

96

B3EWF7
GLRGHPGSRGAPFPH

PABPN1L

236

A6NDY0
GTEPPGRHRTPHGGR

CATSPERD

781

Q86XM0
AGIPGHPGHNGAPGR

ADIPOQ

41

Q15848
LPGNPGGRGHGGGRH

ATXN1

46

P54253
GHESRGPPPHELRGG

CSTF2

361

P33240
RHPPGGGGGQRSLSP

RBM15

281

Q96T37
RGSRGHLHTHPPGPG

OCEL1

66

Q9H607
GGVSGTHHPRPGHDP

MAP1A

2546

P78559
HLPSHGSGRGALPGP

LZTS2

246

Q9BRK4
GAGDAPLGSRPGHPH

NCKAP5L

411

Q9HCH0
KGGRPGGFPDHPHRG

PIR

46

O00625
PHRGPGLPHGGTGRS

C6orf132

1071

Q5T0Z8
GHGRPPGARPPHRGG

FZD8

181

Q9H461
APLGPRESGGHHRPG

CEP126

26

Q9P2H0
GGAPRPGRNHGLPGS

BCAS4

6

Q8TDM0
PGHRPAPRGGGGSAL

CAMKK2

541

Q96RR4
RQPPLPHRSRGGGGG

KHDRBS1

36

Q07666
PGSHPRHGAGGRPKP

HOXA2

61

O43364
PGPGHGGPTRGSFHK

PRR3

111

P79522
HHRGGSPGEGVLGPP

INTS5

451

Q6P9B9
RGGGEPRGGRQHHPP

SFPQ

236

P23246
GGHGHGHGLPKGPRV

SLC30A1

151

Q9Y6M5
GPHTHPGLLRGGAGG

KCNC3

616

Q14003