Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	CBLL1 RNF44 UHRF1 DTX2 UHRF2 MED12 RNF111	1.66e-04	372	63	7	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	CBLL1 RNF44 UHRF1 DTX2 UHRF2 MED12 RNF111	2.51e-04	398	63	7	GO:0061659
GeneOntologyMolecularFunction	aminoacyltransferase activity	CBLL1 RNF44 UHRF1 DTX2 UHRF2 MED12 RNF111 GGT7	2.57e-04	532	63	8	GO:0016755
GeneOntologyMolecularFunction	toxin transmembrane transporter activity	LRP6 LRP5	6.34e-04	12	63	2	GO:0019534
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	CBLL1 RNF44 UHRF1 DTX2 UHRF2 MED12 RNF111	7.05e-04	473	63	7	GO:0004842
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	CBLL1 RNF44 UHRF1 DTX2 UHRF2 MED12 RNF111	1.12e-03	512	63	7	GO:0019787
GeneOntologyMolecularFunction	Wnt receptor activity	LRP6 LRP5	1.29e-03	17	63	2	GO:0042813
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	TET2 GSX1 ZBTB16 SPI1 ATXN1 GATA3 AUTS2 UHRF1 LRP6 LRP5 KDM6B ASH2L MED12 EBF4	5.08e-05	1390	62	14	GO:0045944
GeneOntologyBiologicalProcess	pro-T cell differentiation	SPI1 GATA3	5.31e-05	4	62	2	GO:0002572
GeneOntologyBiologicalProcess	chromatin remodeling	TET2 SPI1 CECR2 GATA3 UHRF1 RERE KDM6B KMT2E UHRF2 ASH2L	6.68e-05	741	62	10	GO:0006338
GeneOntologyBiologicalProcess	embryonic digit morphogenesis	ZBTB16 FUZ LRP6 LRP5	7.27e-05	74	62	4	GO:0042733
GeneOntologyBiologicalProcess	Norrin signaling pathway	LRP6 LRP5	8.84e-05	5	62	2	GO:0110135
GeneOntologyBiologicalProcess	embryonic epithelial tube formation	CECR2 GATA3 FUZ LRP6 MED12	1.16e-04	159	62	5	GO:0001838
GeneOntologyBiologicalProcess	establishment of blood-retinal barrier	LRP6 LRP5	1.32e-04	6	62	2	GO:1990963
GeneOntologyBiologicalProcess	apoptotic process involved in blood vessel morphogenesis	SPI1 LRP5	1.32e-04	6	62	2	GO:1902262
GeneOntologyBiologicalProcess	axis elongation involved in somitogenesis	LRP6 MED12	1.32e-04	6	62	2	GO:0090245
GeneOntologyBiologicalProcess	protein ubiquitination	CBLL1 ZSWIM8 ZBTB16 ANAPC1 RNF44 UHRF1 DTX2 UHRF2 MED12 RNF111	1.41e-04	811	62	10	GO:0016567
GeneOntologyBiologicalProcess	epithelial tube formation	CECR2 GATA3 FUZ LRP6 MED12	1.72e-04	173	62	5	GO:0072175
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	CBLL1 ZSWIM8 ZBTB16 ANAPC1 RNF44 UHRF1 DTX2 USP54 UHRF2 MED12 RNF111	1.86e-04	1009	62	11	GO:0070647
GeneOntologyBiologicalProcess	tube formation	CECR2 GATA3 FUZ LRP6 MED12	2.47e-04	187	62	5	GO:0035148
GeneOntologyBiologicalProcess	morphogenesis of embryonic epithelium	CECR2 GATA3 FUZ LRP6 MED12	2.66e-04	190	62	5	GO:0016331
GeneOntologyBiologicalProcess	protein modification by small protein conjugation	CBLL1 ZSWIM8 ZBTB16 ANAPC1 RNF44 UHRF1 DTX2 UHRF2 MED12 RNF111	3.06e-04	893	62	10	GO:0032446
GeneOntologyBiologicalProcess	chromatin organization	TET2 SPI1 CECR2 GATA3 UHRF1 RERE KDM6B KMT2E UHRF2 ASH2L	3.14e-04	896	62	10	GO:0006325
GeneOntologyBiologicalProcess	mesodermal cell migration	LRP6 LRP5	3.16e-04	9	62	2	GO:0008078
GeneOntologyBiologicalProcess	post-translational protein modification	CBLL1 ZSWIM8 ZBTB16 ANAPC1 RNF44 UHRF1 DTX2 USP54 UHRF2 MED12 RNF111	3.19e-04	1074	62	11	GO:0043687
GeneOntologyBiologicalProcess	neural tube closure	CECR2 FUZ LRP6 MED12	3.73e-04	113	62	4	GO:0001843
GeneOntologyBiologicalProcess	tube closure	CECR2 FUZ LRP6 MED12	3.86e-04	114	62	4	GO:0060606
GeneOntologyBiologicalProcess	epigenetic regulation of gene expression	TET2 SPI1 UHRF1 KMT2E UHRF2 ASH2L	4.64e-04	330	62	6	GO:0040029
GeneOntologyBiologicalProcess	primary neural tube formation	CECR2 FUZ LRP6 MED12	4.68e-04	120	62	4	GO:0014020
GeneOntologyBiologicalProcess	embryonic neurocranium morphogenesis	FUZ MED12	4.80e-04	11	62	2	GO:0048702
GeneOntologyBiologicalProcess	connective tissue development	ZBTB16 SPI1 TRPS1 GATA3 LRP6 LRP5	5.68e-04	343	62	6	GO:0061448
GeneOntologyBiologicalProcess	neural tube formation	CECR2 FUZ LRP6 MED12	7.10e-04	134	62	4	GO:0001841
GeneOntologyBiologicalProcess	protein-DNA complex organization	TET2 SPI1 CECR2 GATA3 UHRF1 RERE KDM6B KMT2E UHRF2 ASH2L	7.37e-04	999	62	10	GO:0071824
GeneOntologyBiologicalProcess	mesenchymal cell proliferation	DCHS2 LRP6 LRP5	7.46e-04	59	62	3	GO:0010463
GeneOntologyBiologicalProcess	myeloid progenitor cell differentiation	TET2 SPI1	7.90e-04	14	62	2	GO:0002318
GeneOntologyCellularComponent	euchromatin	CECR2 UHRF1 KMT2E ASH2L	6.20e-05	72	62	4	GO:0000791
GeneOntologyCellularComponent	Wnt-Frizzled-LRP5/6 complex	LRP6 LRP5	8.61e-05	5	62	2	GO:1990851
GeneOntologyCellularComponent	MLL3/4 complex	KDM6B ASH2L	5.60e-04	12	62	2	GO:0044666
GeneOntologyCellularComponent	Wnt signalosome	LRP6 LRP5	1.01e-03	16	62	2	GO:1990909
MousePheno	perinatal lethality	TET2 FNDC3B ZSWIM8 GSX1 SPI1 CECR2 TRPS1 GATA3 AUTS2 FUZ LRP6 RERE KDM6B KMT2E ZNF503	7.42e-06	1130	51	15	MP:0002081
MousePheno	neonatal lethality	TET2 FNDC3B ZSWIM8 GSX1 SPI1 TRPS1 AUTS2 FUZ LRP6 KDM6B KMT2E ZNF503	2.25e-05	799	51	12	MP:0002058
MousePheno	delayed bone ossification	TRPS1 FUZ LRP6 LRP5 KDM6B	9.61e-05	127	51	5	MP:0000060
MousePheno	neonatal lethality, complete penetrance	FNDC3B ZSWIM8 SPI1 TRPS1 AUTS2 FUZ LRP6 KDM6B ZNF503	1.17e-04	534	51	9	MP:0011087
MousePheno	abnormal craniofacial development	SPI1 TRPS1 GATA3 FUZ UHRF1 LRP6 RERE MED12	1.38e-04	425	51	8	MP:0003935
Domain	ZnF_GATA	TRPS1 GATA3 RERE	8.26e-06	12	64	3	SM00401
Domain	SRA	UHRF1 UHRF2	1.16e-05	2	64	2	SM00466
Domain	-	UHRF1 UHRF2	1.16e-05	2	64	2	2.30.280.10
Domain	YDG	UHRF1 UHRF2	1.16e-05	2	64	2	PS51015
Domain	LRP5/6	LRP6 LRP5	1.16e-05	2	64	2	IPR017049
Domain	TTD_dom	UHRF1 UHRF2	1.16e-05	2	64	2	IPR021991
Domain	TTD	UHRF1 UHRF2	1.16e-05	2	64	2	PF12148
Domain	SRA_YDG	UHRF1 UHRF2	1.16e-05	2	64	2	IPR003105
Domain	SAD_SRA	UHRF1 UHRF2	1.16e-05	2	64	2	PF02182
Domain	Znf_GATA	TRPS1 GATA3 RERE	1.70e-05	15	64	3	IPR000679
Domain	GATA	TRPS1 GATA3 RERE	1.70e-05	15	64	3	PF00320
Domain	LY	LRP6 LRP5 ROS1	1.70e-05	15	64	3	SM00135
Domain	LDLR_classB_rpt	LRP6 LRP5 ROS1	1.70e-05	15	64	3	IPR000033
Domain	GATA_ZN_FINGER_1	TRPS1 GATA3 RERE	2.08e-05	16	64	3	PS00344
Domain	GATA_ZN_FINGER_2	TRPS1 GATA3 RERE	2.08e-05	16	64	3	PS50114
Domain	-	LRP6 LRP5 ROS1	3.21e-04	39	64	3	2.120.10.30
Domain	ZF_RING_1	CBLL1 RNF44 UHRF1 DTX2 UHRF2 RNF111	4.77e-04	291	64	6	PS00518
Domain	6-blade_b-propeller_TolB-like	LRP6 LRP5 ROS1	5.24e-04	46	64	3	IPR011042
Domain	ZF_RING_2	CBLL1 RNF44 UHRF1 DTX2 UHRF2 RNF111	5.41e-04	298	64	6	PS50089
Domain	RING	CBLL1 RNF44 UHRF1 DTX2 UHRF2 RNF111	6.11e-04	305	64	6	SM00184
Domain	-	CBLL1 RNF44 UHRF1 DTX2 KMT2E UHRF2 RNF111	8.44e-04	449	64	7	3.30.40.10
Domain	Znf_RING	CBLL1 RNF44 UHRF1 DTX2 UHRF2 RNF111	8.65e-04	326	64	6	IPR001841
Domain	Znf_RING/FYVE/PHD	CBLL1 RNF44 UHRF1 DTX2 KMT2E UHRF2 RNF111	9.60e-04	459	64	7	IPR013083
Domain	-	TRPS1 GATA3 RERE	9.84e-04	57	64	3	3.30.50.10
Domain	Ldl_recept_b	LRP6 LRP5	1.02e-03	14	64	2	PF00058
Domain	LDLRB	LRP6 LRP5	1.02e-03	14	64	2	PS51120
Domain	Znf_NHR/GATA	TRPS1 GATA3 RERE	1.04e-03	58	64	3	IPR013088
Domain	Rib_L2_dom2	UHRF1 UHRF2	1.71e-03	18	64	2	IPR014722
Domain	-	UHRF1 UHRF2	1.71e-03	18	64	2	2.30.30.30
Domain	PUA-like_domain	UHRF1 UHRF2	1.90e-03	19	64	2	IPR015947
Domain	PHD	UHRF1 KMT2E UHRF2	2.17e-03	75	64	3	PF00628
Domain	Znf_PHD-finger	UHRF1 KMT2E UHRF2	2.52e-03	79	64	3	IPR019787
Domain	PHD	UHRF1 KMT2E UHRF2	3.53e-03	89	64	3	SM00249
Domain	-	STAM2 RPRD2	3.56e-03	26	64	2	1.25.40.90
Domain	Znf_PHD	UHRF1 KMT2E UHRF2	3.76e-03	91	64	3	IPR001965
Domain	ZF_PHD_2	UHRF1 KMT2E UHRF2	4.24e-03	95	64	3	PS50016
Domain	ZF_PHD_1	UHRF1 KMT2E UHRF2	4.37e-03	96	64	3	PS01359
Domain	ENTH_VHS	STAM2 RPRD2	4.42e-03	29	64	2	IPR008942
Domain	UBIQUITIN_1	UHRF1 UHRF2	7.13e-03	37	64	2	PS00299
Domain	zf-C3HC4	RNF44 DTX2 UHRF2 RNF111	7.19e-03	223	64	4	PF00097
Domain	LDLR_class-A_CS	LRP6 LRP5	8.29e-03	40	64	2	IPR023415
Domain	UBQ	UHRF1 UHRF2	9.54e-03	43	64	2	SM00213
Pathway	WP_WNTBETACATENIN_SIGNALING_IN_LEUKEMIA	ZBTB16 LRP6 LRP5	7.51e-05	26	45	3	M39407
Pathway	WP_WNTBETACATENIN_SIGNALING_INHIBITORS_IN_CURRENT_AND_PAST_CLINICAL_TRIALS	LRP6 LRP5	9.90e-05	5	45	2	M48304
Pathway	REACTOME_SIGNALING_BY_RNF43_MUTANTS	LRP6 LRP5	2.76e-04	8	45	2	M27433
Pathway	REACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_WNT_LIGAND_ANTAGONISTS	LRP6 LRP5	2.76e-04	8	45	2	MM14976
Pubmed	Interaction network of human early embryonic transcription factors.	TET2 ATXN1 TRPS1 AUTS2 UHRF1 RERE UHRF2 ASH2L MED12 ZNF503	1.23e-09	351	66	10	38297188
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TET2 CECR2 RNF44 AUTS2 RPRD2 AMOTL2 KDM6B ESPL1 DHX34 DAGLA	5.99e-08	529	66	10	14621295
Pubmed	Human transcription factor protein interaction networks.	TET2 ATXN1 TRPS1 GATA3 AUTS2 LRP6 DDX56 RPRD2 ZNF318 RERE USP54 R3HDM1 ASH2L ZNF503	3.83e-07	1429	66	14	35140242
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	TET2 ATXN1 TRPS1 RPRD2 RERE ASH2L MED12	7.88e-07	268	66	7	33640491
Pubmed	The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1.	RNF44 DTX2 UHRF2	1.07e-06	11	66	3	28536267
Pubmed	ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression.	GATA3 ZNF503	3.55e-06	2	66	2	28258171
Pubmed	Trps1 haploinsufficiency promotes renal fibrosis by increasing Arkadia expression.	TRPS1 RNF111	3.55e-06	2	66	2	20507941
Pubmed	Evidence against a human cell-specific role for LRP6 in anthrax toxin entry.	LRP6 LRP5	3.55e-06	2	66	2	18350154
Pubmed	PU.1 regulates TCR expression by modulating GATA-3 activity.	SPI1 GATA3	3.55e-06	2	66	2	19801513
Pubmed	Clinical Phenotype and Relevance of LRP5 and LRP6 Variants in Patients With Early-Onset Osteoporosis (EOOP).	LRP6 LRP5	3.55e-06	2	66	2	33118644
Pubmed	Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6.	LRP6 LRP5	3.55e-06	2	66	2	21887268
Pubmed	MiR-196a promotes the proliferation and migration of esophageal cancer via the UHRF2/TET2 axis.	TET2 UHRF2	3.55e-06	2	66	2	34826027
Pubmed	PAR1&2 driven placenta EVT invasion act via LRP5/6 as coreceptors.	LRP6 LRP5	3.55e-06	2	66	2	33136328
Pubmed	Lack of association of LRP5 and LRP6 polymorphisms with type 2 diabetes mellitus in the Japanese population.	LRP6 LRP5	3.55e-06	2	66	2	18493104
Pubmed	GATA3 and TRPS1 are distinct biomarkers and prognostic factors in breast cancer: database mining for GATA family members in malignancies.	TRPS1 GATA3	3.55e-06	2	66	2	28423734
Pubmed	Definition of regulatory network elements for T cell development by perturbation analysis with PU.1 and GATA-3.	SPI1 GATA3	3.55e-06	2	66	2	12027437
Pubmed	LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.	LRP6 LRP5	3.55e-06	2	66	2	15084453
Pubmed	ZNF503 combined with GATA3 is a prognostic factor in triple-negative breast cancer.	GATA3 ZNF503	3.55e-06	2	66	2	37036735
Pubmed	Cooperation between KDM6B overexpression and TET2 deficiency in the pathogenesis of chronic myelomonocytic leukemia.	TET2 KDM6B	3.55e-06	2	66	2	35697791
Pubmed	UHRF genes regulate programmed interdigital tissue regression and chondrogenesis in the embryonic limb.	UHRF1 UHRF2	3.55e-06	2	66	2	31024001
Pubmed	A gene regulatory network armature for T lymphocyte specification.	SPI1 GATA3	3.55e-06	2	66	2	19104054
Pubmed	Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells.	LRP6 LRP5	3.55e-06	2	66	2	30668923
Pubmed	PU.1-Dependent Enhancer Inhibition Separates Tet2-Deficient Hematopoiesis from Malignant Transformation.	TET2 SPI1	3.55e-06	2	66	2	35820129
Pubmed	Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.	LRP6 LRP5	3.55e-06	2	66	2	22433869
Pubmed	Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration.	LRP6 LRP5	3.55e-06	2	66	2	33164872
Pubmed	TRPS1 and GATA3 Expression in Invasive Breast Carcinoma With Apocrine Differentiation.	TRPS1 GATA3	3.55e-06	2	66	2	37074839
Pubmed	LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis.	LRP6 LRP5	3.55e-06	2	66	2	25902418
Pubmed	Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast.	LRP6 LRP5	3.55e-06	2	66	2	25802278
Pubmed	TRPS1 outperforms GATA3 in pleural effusions with metastatic breast carcinoma versus mesothelioma.	TRPS1 GATA3	3.55e-06	2	66	2	37096814
Pubmed	The involvement of the canonical Wnt-signaling receptor LRP5 and LRP6 gene variants with ADHD and sexual dimorphism: Association study and meta-analysis.	LRP6 LRP5	3.55e-06	2	66	2	30474181
Pubmed	In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions.	LRP6 LRP5	3.55e-06	2	66	2	36552732
Pubmed	Idiopathic Juvenile Osteoporosis: Clinical Experience from a Single Centre and Screening of LRP5 and LRP6 Genes.	LRP6 LRP5	3.55e-06	2	66	2	25783012
Pubmed	Gene targeting approaches in mice: assessing the roles of LRP5 and LRP6 in osteoblasts.	LRP6 LRP5	3.55e-06	2	66	2	19147944
Pubmed	Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6.	LRP6 LRP5	3.55e-06	2	66	2	15537447
Pubmed	Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina.	LRP6 LRP5	3.55e-06	2	66	2	33545636
Pubmed	LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin.	LRP6 LRP5	3.55e-06	2	66	2	17335347
Pubmed	Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density.	LRP6 LRP5	3.55e-06	2	66	2	12579474
Pubmed	The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development.	LRP6 LRP5	3.55e-06	2	66	2	19503830
Pubmed	LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women.	LRP6 LRP5	3.55e-06	2	66	2	37202775
Pubmed	Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication.	LRP6 LRP5	3.55e-06	2	66	2	20926594
Pubmed	Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men.	LRP6 LRP5	3.55e-06	2	66	2	16355283
Pubmed	Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo.	LRP6 LRP5	3.55e-06	2	66	2	28425175
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZBTB16 RNF44 TRPS1 GATA3 ZNF318 UHRF2 ZBTB3 ASH2L RNF111	7.59e-06	709	66	9	22988430
Pubmed	Canonical Wnt Signaling in CD11c+ APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon.	LRP6 LRP5	1.06e-05	3	66	2	29602775
Pubmed	IL4 blockade of inducible regulatory T cell differentiation: the role of Th2 cells, Gata3 and PU.1.	SPI1 GATA3	1.06e-05	3	66	2	19046990
Pubmed	TRPS1, GATA3, and SOX10 expression in triple-negative breast carcinoma.	TRPS1 GATA3	1.06e-05	3	66	2	35413381
Pubmed	Multivesicular GSK3 sequestration upon Wnt signaling is controlled by p120-catenin/cadherin interaction with LRP5/6.	LRP6 LRP5	1.06e-05	3	66	2	24412065
Pubmed	LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children.	LRP6 LRP5	1.06e-05	3	66	2	18721193
Pubmed	tPA regulates neurite outgrowth by phosphorylation of LRP5/6 in neural progenitor cells.	LRP6 LRP5	1.06e-05	3	66	2	23925701
Pubmed	Structural insight into the mechanisms of Wnt signaling antagonism by Dkk.	LRP6 LRP5	1.06e-05	3	66	2	18524778
Pubmed	PU.1 Suppresses Th2 Cytokine Expression via Silencing of GATA3 Transcription in Dendritic Cells.	SPI1 GATA3	1.06e-05	3	66	2	26361334
Pubmed	Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.	LRP6 LRP5	1.06e-05	3	66	2	25710911
Pubmed	The structural basis of DKK-mediated inhibition of Wnt/LRP signaling.	LRP6 LRP5	1.06e-05	3	66	2	22589387
Pubmed	UV-induced activation of ATR is mediated by UHRF2.	UHRF1 UHRF2	1.06e-05	3	66	2	33848395
Pubmed	Association of CD30 transcripts with Th1 responses and proinflammatory cytokines in patients with end-stage renal disease.	TNFRSF8 GATA3	1.06e-05	3	66	2	26970513
Pubmed	Wnt co-receptor LRP5/6 overexpression confers protection against hydrogen peroxide-induced neurotoxicity and reduces tau phosphorylation in SH-SY5Y cells.	LRP6 LRP5	1.06e-05	3	66	2	25959626
Pubmed	Absent, small or homeotic 2-like protein (ASH2L) enhances the transcription of the estrogen receptor α gene through GATA-binding protein 3 (GATA3).	GATA3 ASH2L	1.06e-05	3	66	2	25258321
Pubmed	Mature miR-183, negatively regulated by transcription factor GATA3, promotes 3T3-L1 adipogenesis through inhibition of the canonical Wnt/β-catenin signaling pathway by targeting LRP6.	GATA3 LRP6	1.06e-05	3	66	2	24556500
Pubmed	Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and β-catenin.	LRP6 LRP5	1.06e-05	3	66	2	27803037
Pubmed	Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6.	LRP6 LRP5	1.06e-05	3	66	2	21397183
Pubmed	Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.	LRP6 LRP5	1.06e-05	3	66	2	22000856
Pubmed	Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts.	LRP6 LRP5	1.06e-05	3	66	2	18406176
Pubmed	Molecular simulation analysis of the structure complex of C2 domains of DKK family members and β-propeller domains of LRP5/6: explaining why DKK3 does not bind to LRP5/6.	LRP6 LRP5	1.06e-05	3	66	2	24743782
Pubmed	Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells.	SPI1 GATA3	1.06e-05	3	66	2	34180951
Pubmed	Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway.	LRP6 LRP5	1.06e-05	3	66	2	33650028
Pubmed	Lrp5 and Lrp6 play compensatory roles in mouse intestinal development.	LRP6 LRP5	1.06e-05	3	66	2	21866564
Pubmed	Molecular investigation of the tandem Tudor domain and plant homeodomain histone binding domains of the epigenetic regulator UHRF2.	UHRF1 UHRF2	1.06e-05	3	66	2	34766381
Pubmed	Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.	LRP6 LRP5	1.06e-05	3	66	2	30664649
Pubmed	Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation.	LRP6 LRP5	1.06e-05	3	66	2	22576936
Pubmed	PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation.	TET2 SPI1	1.06e-05	3	66	2	24028770
Pubmed	Depletion of canonical Wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an MPTP-induced mouse model of Parkinson's disease.	LRP6 LRP5	1.06e-05	3	66	2	25009587
Pubmed	TRAP1 Regulates Wnt/β-Catenin Pathway through LRP5/6 Receptors Expression Modulation.	LRP6 LRP5	1.06e-05	3	66	2	33065966
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	TET2 AUTS2 DTX2 R3HDM1 ZNF503	1.08e-05	152	66	5	38360978
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TET2 ANAPC1 TRPS1 NAV1 ZNF318 RERE MED12	1.46e-05	418	66	7	34709266
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	ZSWIM8 STAM2 ATXN1 RBFOX1 DTX2 RERE USP54 R3HDM1	1.96e-05	608	66	8	16713569
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	ANAPC1 DDX56 RPRD2 ZNF318 USP54 ESPL1 ASH2L	2.02e-05	440	66	7	34244565
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ZBTB16 ATXN1 TRPS1 AUTS2 NAV1 LRP5 DDX56 RPRD2 IGSF9B RERE BCAR1 DAGLA	2.09e-05	1489	66	12	28611215
Pubmed	Architecture of a lymphomyeloid developmental switch controlled by PU.1, Notch and Gata3.	SPI1 GATA3	2.12e-05	4	66	2	23444353
Pubmed	Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance.	UHRF1 UHRF2	2.12e-05	4	66	2	29506131
Pubmed	Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.	LRP6 LRP5	2.12e-05	4	66	2	22696217
Pubmed	PU.1 expression delineates heterogeneity in primary Th2 cells.	SPI1 GATA3	2.12e-05	4	66	2	15963784
Pubmed	Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function.	LRP6 LRP5	2.12e-05	4	66	2	21471202
Pubmed	Lrp5/6 are required for cerebellar development and for suppressing TH expression in Purkinje cells via β-catenin.	LRP6 LRP5	2.12e-05	4	66	2	26772978
Pubmed	The Wnt-β-Catenin-IL-10 Signaling Axis in Intestinal APCs Protects Mice from Colitis-Associated Colon Cancer in Response to Gut Microbiota.	LRP6 LRP5	2.12e-05	4	66	2	32917787
Pubmed	NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein.	UHRF1 UHRF2	2.12e-05	4	66	2	14741369
Pubmed	Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts.	LRP6 LRP5	2.12e-05	4	66	2	29176883
Pubmed	Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.	LRP6 LRP5	2.12e-05	4	66	2	17002572
Pubmed	Oligomerization of Frizzled and LRP5/6 protein initiates intracellular signaling for the canonical WNT/β-catenin pathway.	LRP6 LRP5	2.12e-05	4	66	2	30361437
Pubmed	Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins.	LRP6 LRP5	2.12e-05	4	66	2	15064719
Pubmed	Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma.	LRP6 LRP5	2.12e-05	4	66	2	20846389
Pubmed	Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism.	LRP6 LRP5	2.12e-05	4	66	2	18502762
Pubmed	Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow.	LRP6 LRP5	2.12e-05	4	66	2	11433302
Pubmed	Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes.	RBFOX1 AUTS2	2.12e-05	4	66	2	19546859
Pubmed	SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.	LRP6 LRP5	2.12e-05	4	66	2	15908424
Pubmed	Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition.	LRP6 LRP5	2.12e-05	4	66	2	23675479
Pubmed	Shh Plays an Inhibitory Role in Cusp Patterning by Regulation of Sostdc1.	LRP6 LRP5	2.12e-05	4	66	2	30325689
Pubmed	Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice.	LRP6 LRP5	2.12e-05	4	66	2	31452509
Pubmed	Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation.	LRP6 LRP5	2.12e-05	4	66	2	18762581
Pubmed	The role of Lrp5/6 in cardiac valve disease: experimental hypercholesterolemia in the ApoE-/- /Lrp5-/- mice.	LRP6 LRP5	2.12e-05	4	66	2	21678468
Pubmed	Critical Endothelial Regulation by LRP5 during Retinal Vascular Development.	LRP6 LRP5	2.12e-05	4	66	2	27031698
Interaction	HDAC1 interactions	TET2 MAGEA3 ZBTB16 SPI1 ATXN1 TRPS1 GATA3 NAV1 PHLPP1 UHRF1 PRRG4 ZNF318 RERE KMT2E UHRF2 ASH2L MED12	4.01e-08	1108	64	17	int:HDAC1
Interaction	TLE3 interactions	CBLL1 TET2 ATXN1 CECR2 TRPS1 GATA3 AUTS2 ZNF318 RERE ZNF503	2.80e-07	376	64	10	int:TLE3
Interaction	CDC16 interactions	ATXN1 ANAPC1 TRPS1 ZNF318 USP54 UHRF2 ESPL1 MED12	1.08e-06	246	64	8	int:CDC16
Interaction	SP7 interactions	TET2 ATXN1 TRPS1 RPRD2 ZNF318 RERE ASH2L ZNF503	5.20e-06	304	64	8	int:SP7
Interaction	ERG interactions	TET2 SPI1 ATXN1 TRPS1 UHRF1 RERE RNF111	6.72e-06	223	64	7	int:ERG
Interaction	GSC interactions	ATXN1 TRPS1 AUTS2 RERE ZNF503	8.33e-06	87	64	5	int:GSC
Interaction	ATN1 interactions	ZSWIM8 RBFOX1 AUTS2 RERE USP54 ZNF503	2.83e-05	187	64	6	int:ATN1
Interaction	DNMT3B interactions	SPI1 UHRF1 LRP6 LRP5 UHRF2	3.10e-05	114	64	5	int:DNMT3B
Interaction	GATA2 interactions	ZBTB16 SPI1 ATXN1 TRPS1 GATA3 ZNF503	4.00e-05	199	64	6	int:GATA2
Interaction	WWTR1 interactions	STAM2 ANAPC1 RPRD2 PRRG4 ZNF318 DTX2 AMOTL2 ASH2L	5.49e-05	422	64	8	int:WWTR1
Interaction	HDAC2 interactions	TET2 ZBTB16 SPI1 TRPS1 GATA3 UHRF1 RPRD2 ZNF318 RERE ESPL1 ASH2L	7.91e-05	865	64	11	int:HDAC2
Interaction	ZNF609 interactions	ATXN1 GATA3 AUTS2 DTX2 RERE	1.01e-04	146	64	5	int:ZNF609
Interaction	ARID5A interactions	ATXN1 RNF44 RBFOX1 DTX2 ZNF503	1.04e-04	147	64	5	int:ARID5A
Interaction	MESD interactions	LRP6 LRP5 ROS1 BCAR1 ASH2L	1.46e-04	158	64	5	int:MESD
Interaction	TENT5A interactions	FNDC3B ATXN1 RNF44 ESPL1	1.47e-04	84	64	4	int:TENT5A
Interaction	PRDM1 interactions	SPI1 ATXN1 TRPS1 ZNF503	1.47e-04	84	64	4	int:PRDM1
Interaction	CRX interactions	TET2 ATXN1 RBFOX1 TRPS1 RERE MED12	1.54e-04	254	64	6	int:CRX
Interaction	HSFY1 interactions	ATXN1 RBFOX1 DTX2	1.70e-04	34	64	3	int:HSFY1
Interaction	FOXI1 interactions	TRPS1 DTX2 USP54 ZNF503	2.10e-04	92	64	4	int:FOXI1
Cytoband	10q22.2	ZSWIM8 USP54 ZNF503	2.91e-05	41	66	3	10q22.2
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	TRPS1 GATA3 RERE	6.86e-06	15	46	3	82
GeneFamily	Ring finger proteins	CBLL1 RNF44 UHRF1 DTX2 UHRF2 RNF111	6.59e-05	275	46	6	58
GeneFamily	PHD finger proteins	UHRF1 KMT2E UHRF2 ASH2L	7.98e-05	90	46	4	88
GeneFamily	Low density lipoprotein receptors	LRP6 LRP5	4.85e-04	13	46	2	634
GeneFamily	Tudor domain containing	UHRF1 UHRF2	3.99e-03	37	46	2	780
GeneFamily	Fibronectin type III domain containing	FNDC3B ROS1 IGSF9B	7.81e-03	160	46	3	555
ToppCell	wk_20-22-Hematologic-Myeloid-Promyelocyte-like\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	SPI1 WDR97 HYAL3 UHRF1 DHX34	6.37e-06	176	66	5	ee33d7077a92c1fd371081e7c990c7266e711957
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_NK-T_mait-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZBTB16 INTS15 FUZ GGT7 ENOX2	8.34e-06	186	66	5	927723ad579bbd9947ff525bd501e222d3fa9289
ToppCell	IPF-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	TET2 TNFRSF8 TRPS1 PHLPP1 FAAH2	9.01e-06	189	66	5	7a260485c2a7c743c14d048e5e480ae0a9b8e32c
ToppCell	COPD-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	TET2 TRPS1 PHLPP1 UHRF2 FAAH2	9.48e-06	191	66	5	3ae18bc4e3dff49b5d5958da8ebc3f747274b69c
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Tcf7l2_(Entopeduncular_Nucleus_(Ent))--\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	DCHS2 TNFRSF8 GATA3 PTCH2	9.81e-06	90	66	4	27865bd63dda0624e62a3b713464a490b588d3ae
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Tcf7l2_(Entopeduncular_Nucleus_(Ent))\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	DCHS2 TNFRSF8 GATA3 PTCH2	9.81e-06	90	66	4	8c2eb7444f938faade7c81a60c004252d588c80b
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Tcf7l2_(Entopeduncular_Nucleus_(Ent))-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	DCHS2 TNFRSF8 GATA3 PTCH2	9.81e-06	90	66	4	4bc53b521abb79fc53ac912f1dc2e3c55426b2e0
ToppCell	356C-Epithelial_cells-Epithelial-H_(AT1)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	STAM2 LRP5 ZNF318 EBF4 GGT7	1.02e-05	194	66	5	4c40d6b50675eae52c419d69e719a9223df02ae3
ToppCell	356C-Epithelial_cells-Epithelial-H_(AT1)\|356C / Donor, Lineage, Cell class and subclass (all cells)	STAM2 LRP5 ZNF318 EBF4 GGT7	1.02e-05	194	66	5	99a90de637e3babec2131cdd9f05ea965d8a8f30
ToppCell	CF-Myeloid\|CF / Disease state, Lineage and Cell class	FNDC3B SPI1 ATXN1 KDM6B DHX34	1.05e-05	195	66	5	ecf604de496f389a49429d0bb211e1db6019cc8b
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	FNDC3B ATXN1 TRPS1 AUTS2 RERE	1.16e-05	199	66	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
Disease	neuroticism measurement, cognitive function measurement	TET2 RBFOX1 TRPS1 AUTS2 NAV1 UHRF1 IGSF9B RERE	2.37e-05	566	62	8	EFO_0007660, EFO_0008354
Disease	spine bone mineral density	DCHS2 RBFOX1 LRP5 ESPL1	1.17e-04	119	62	4	EFO_0007701
Disease	Acute Promyelocytic Leukemia	TET2 FNDC3B ZBTB16	1.26e-04	46	62	3	C0023487
Disease	neutrophil count	TET2 ZBTB16 SPI1 ATXN1 RBFOX1 UHRF1 RPRD2 RERE R3HDM1 KDM6B KMT2E	1.29e-04	1382	62	11	EFO_0004833
Disease	pulse pressure measurement	TET2 FNDC3B STAM2 ATXN1 TRPS1 NAV1 UHRF1 ZNF318 BCAR1 KDM6B DHX34	1.37e-04	1392	62	11	EFO_0005763
Disease	MENTAL RETARDATION, AUTOSOMAL DOMINANT 40	KMT2E DHX34	1.55e-04	9	62	2	C4225275
Disease	testosterone measurement	TET2 DCHS2 ANAPC1 CECR2 TRPS1 AUTS2 LRP5 ZNF318 KDM6B MED12	3.04e-04	1275	62	10	EFO_0004908
Disease	unipolar depression, bipolar disorder	STARD9 RBFOX1 RPRD2 RERE	3.30e-04	156	62	4	EFO_0003761, MONDO_0004985
Disease	Adult Hodgkin Lymphoma	TNFRSF8 GATA3	3.34e-04	13	62	2	C0220597
Disease	Hodgkin lymphoma, lymphocyte depletion	TNFRSF8 GATA3	3.34e-04	13	62	2	C0152267
Disease	Mixed Cellularity Hodgkin Lymphoma	TNFRSF8 GATA3	3.34e-04	13	62	2	C0152266
Disease	Lymphocyte Rich Classical Hodgkin Lymphoma	TNFRSF8 GATA3	3.34e-04	13	62	2	C1266194
Disease	Nodular Lymphocyte Predominant Hodgkin Lymphoma	TNFRSF8 GATA3	3.34e-04	13	62	2	C1334968
Disease	chronotype measurement	ZBTB16 RBFOX1 TRPS1 AUTS2 RPRD2 ZNF318 RERE R3HDM1	5.01e-04	882	62	8	EFO_0008328
Disease	Abnormality of refraction	FNDC3B SPI1 PKD1L1 RBFOX1 AUTS2 RERE DAGLA	5.16e-04	673	62	7	HP_0000539
Disease	age at onset, Parkinson disease	TRPS1 PRRG4	6.50e-04	18	62	2	EFO_0004847, MONDO_0005180
Disease	Myeloid Leukemia	SPI1 KMT2E	6.50e-04	18	62	2	C0023470
Disease	Leukemia, Monocytic, Chronic	SPI1 KMT2E	6.50e-04	18	62	2	C0023466
Disease	Agents acting on the renin-angiotensin system use measurement	TRPS1 AUTS2 UHRF1 ZNF318 KDM6B	6.97e-04	335	62	5	EFO_0009931
Disease	femoral neck bone mineral density	ANAPC1 LRP5 RERE ESPL1	7.79e-04	196	62	4	EFO_0007785
Disease	corneal hysteresis	FNDC3B ANAPC1	8.05e-04	20	62	2	EFO_0010066
Disease	schizophrenia, intelligence, self reported educational attainment	TET2 ATXN1 IGSF9B RERE KMT2E	8.06e-04	346	62	5	EFO_0004337, EFO_0004784, MONDO_0005090
Disease	platelet crit	TET2 ZBTB16 PHLPP1 RPRD2 PRRG4 ZNF318 RERE KDM6B	8.25e-04	952	62	8	EFO_0007985
Disease	monocyte percentage of leukocytes	ZBTB16 ATXN1 CECR2 TRPS1 PHLPP1 RERE KDM6B	8.39e-04	731	62	7	EFO_0007989
Disease	colorectal health	FNDC3B PKD1L1 AUTS2 ESPL1	8.56e-04	201	62	4	EFO_0008460
Disease	Precursor B-cell lymphoblastic leukemia	GATA3 AUTS2	8.89e-04	21	62	2	C1292769
Disease	Hodgkin Disease	TNFRSF8 GATA3	9.77e-04	22	62	2	C0019829
Disease	neutrophil count, eosinophil count	TET2 ZBTB16 ATXN1 RERE	1.06e-03	213	62	4	EFO_0004833, EFO_0004842
Disease	phospholipid measurement, intermediate density lipoprotein measurement	TRPS1 DDX56 RNF111	1.20e-03	99	62	3	EFO_0004639, EFO_0008595
Disease	Adenoid Cystic Carcinoma	UHRF1 KDM6B ESPL1	1.24e-03	100	62	3	C0010606
Disease	parental emotion expression measurmement, conduct disorder	ZBTB16 RBFOX1	1.26e-03	25	62	2	EFO_0004216, EFO_0008342
Disease	neutrophil count, basophil count	TET2 ZBTB16 ATXN1 RERE	1.28e-03	224	62	4	EFO_0004833, EFO_0005090
Disease	bone density	ATXN1 TRPS1 LRP5 RERE ESPL1	1.34e-03	388	62	5	EFO_0003923
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	TET2 RBFOX1 AUTS2 NAV1 IGSF9B	1.50e-03	398	62	5	EFO_0003756, EFO_0003888, EFO_0004337
Disease	eosinophil percentage of granulocytes	ANAPC1 TNFRSF8 RERE KDM6B	1.50e-03	234	62	4	EFO_0007996
Disease	age at menarche	TET2 FNDC3B RBFOX1 RERE FAAH2 GGT7	1.54e-03	594	62	6	EFO_0004703
Disease	reticulocyte measurement	FNDC3B ATXN1 TRPS1 LRP5 AMOTL2 KDM6B MED12 GGT7	1.57e-03	1053	62	8	EFO_0010700
Disease	lower face morphology measurement	DCHS2 ANAPC1 TRPS1	1.58e-03	109	62	3	EFO_0010948
Disease	Iniencephaly	CECR2 FUZ	1.59e-03	28	62	2	C0152234
Disease	level of Phosphatidylethanolamine (18:0_18:2) in blood serum	DAGLA RNF111	1.59e-03	28	62	2	OBA_2045139
Disease	Tethered Cord Syndrome	CECR2 FUZ	1.59e-03	28	62	2	C0080218
Disease	Spinal Cord Myelodysplasia	CECR2 FUZ	1.59e-03	28	62	2	C0344479
Disease	Exencephaly	CECR2 FUZ	1.59e-03	28	62	2	C0266453
Disease	Neurenteric Cyst	CECR2 FUZ	1.59e-03	28	62	2	C0027806
Disease	hearing threshold measurement	RBFOX1 AUTS2	1.59e-03	28	62	2	EFO_0007618
Disease	Acrania	CECR2 FUZ	1.59e-03	28	62	2	C0702169
Disease	Diastematomyelia	CECR2 FUZ	1.59e-03	28	62	2	C0011999
Disease	basophil count, eosinophil count	ANAPC1 TNFRSF8 RERE KDM6B	1.67e-03	241	62	4	EFO_0004842, EFO_0005090
Disease	alopecia	TET2 TRPS1 AUTS2 FAAH2	1.67e-03	241	62	4	MONDO_0004907
Disease	Craniorachischisis	CECR2 FUZ	1.70e-03	29	62	2	C0152426
Disease	Malignant neoplasm of breast	FNDC3B KLK10 GATA3 ZNF318 USP54 BCAR1 ZBTB3 MED12	1.78e-03	1074	62	8	C0006142
Disease	Neural Tube Defects	CECR2 FUZ	1.82e-03	30	62	2	C0027794
Disease	level of Phosphatidylcholine (18:0_20:4) in blood serum	ZBTB3 DAGLA	1.94e-03	31	62	2	OBA_2045094
Disease	atopic eczema	DCHS2 RPRD2 RERE RNF111	1.97e-03	252	62	4	EFO_0000274
Disease	adult onset asthma	GATA3 RERE UHRF2	1.99e-03	118	62	3	EFO_1002011
Disease	granulocyte count	TET2 ZBTB16 ATXN1 RERE	2.02e-03	254	62	4	EFO_0007987
Disease	bitter non-alcoholic beverage consumption measurement	RBFOX1 RPRD2	2.07e-03	32	62	2	EFO_0010093

Protein segments in the cluster

Peptide	Gene	Start	Entry
SRGPPPQYPHVVLAH	AMOTL2	206	Q9Y2J4
GLPPSNHHAVYDVPP	BCAR1	296	P56945
PGTPVSPVQYAHLPH	ATXN1	111	P54253
LSSRVCPPGVPYHPH	CECR2	911	Q9BXF3
SAQRLPPHGYPLEHP	ASH2L	321	Q9UBL3
PLQYNPPAVLHGHIP	R3HDM1	936	Q15032
YGAVPAHPAAHPALP	INTS15	416	Q96N11
YHSVPAPQHLPPIGL	ANAPC1	1891	Q9H1A4
VKISGGPHISYPPLH	MAGEA3	291	P43357
LPAYPVPQHPPHRTA	DTX2	221	Q86UW9
LRPPSPPPVVHYSDH	ENOX2	236	Q16206
PFPHEYVSGTPHVPL	LRP5	1421	O75197
PAPAYTAHPPGHRLV	KDM6B	316	O15054
KPHLGHVPDYLVPPA	DDX56	486	Q9NY93
YRGHLVLSPPPPHTG	GGT7	366	Q9UJ14
YAVPPPHALHGLSPG	GSX1	31	Q9H4S2
HPSLITPGLPSMHYP	AUTS2	1181	Q8WXX7
PHTPVQHGYLSPKPP	KMT2E	1456	Q8IZD2
HGPASVPLGYVPHPS	LRP6	1416	O75581
PYGVTVPPDLLHHPN	MED12	1811	Q93074
PKHPRSPIPYHLGSL	DCHS2	3306	Q6V1P9
PHPPQAAGTPHLVYS	CBLL1	356	Q75N03
SIHHGSPGPLSVYPP	GATA3	121	P23771
HLGLVKPGTYPEVPP	ESPL1	486	Q14674
APLAPSHPHPAVVGI	EBF4	416	Q9BQW3
LHPPPSSVPYFHGER	CPHXL2	226	A0A1W2PPK0
IPPIHVPPGYISQVI	FNDC3B	76	Q53EP0
YLPPRLPPAHHQAFV	HYAL3	246	O43820
YPSHPTVAPKHHVPL	FAAH2	451	Q6GMR7
STPLYPPGRIIHVVH	DAGLA	596	Q9Y4D2
YVGPQTIPATPHLPG	DHX34	1011	Q14147
HSGVVPFPAPPLAEH	RPRD2	1301	Q5VT52
GSEILYPPTQHPPVA	PKD1L1	266	Q8TDX9
PVYLPHGSPTVPHRL	FUZ	221	Q9BT04
PPSPSPGPQVYHRVH	PRR23D1	251	E9PI22
LHHLIPPALNPIVYG	OR56A1	286	Q8NGH5
LYHLPPPTVGPHSIA	NAV1	1811	Q8NEY1
GIPAEYTAPHPHPAP	RBFOX1	36	Q9NWB1
TVAIHPPPLPGAYIH	PTCH2	1161	Q9Y6C5
GLATPPYPHLPVLAS	HDHD5	221	Q9BXW7
PVHPLVDPLTAGPHL	RERE	1451	Q9P2R6
VPPHPSLGHQVSYLP	SPI1	101	P17947
PHTIHPPCVVPSRAY	STARD9	2991	Q9P2P6
PPSPSPGPQVYHRVH	PRR23D2	251	P0DMB1
ALEDLHHTPGYPTPP	C11orf53	166	Q8IXP5
IVPSNHYGPIPGIPV	UHRF2	441	Q96PU4
VPGNPHYLSHVPGLP	TRPS1	1121	Q9UHF7
EHPAPPPEKHLGIYS	ZBTB16	321	Q05516
QPPPQVDYVIPHPVH	RNF111	676	Q6ZNA4
DVIHPVTGQPPPYVV	IGSF9B	46	Q9UPX0
AAHPHPPEPYTVAPV	WDR97	1506	A6NE52
ISSDHYILHPPPPAP	RNF44	176	Q7L0R7
HTPHYPEQETEPPLG	TNFRSF8	556	P28908
KLHPPAHYPPASSGV	STAM2	376	O75886
YRTHPHGVPETAPLI	ROS1	186	P08922
TRKHSVSPPPPYPGH	PRRG4	196	Q9BZD6
TVHPYHTEPGLPLPT	ZSWIM8	1586	A7E2V4
HILHPEYLQPLPSTP	ZNF503	86	Q96F45
TIVPSNHYGPIPGIP	UHRF1	411	Q96T88
PPPPTLYVQLHGETT	PHLPP1	466	O60346
ARLYHHLPDPGLPQP	SH2D4B	266	Q5SQS7
IRPNVHHVGKLPPYP	TET2	1711	Q6N021
KHPGPPFYVPHAEIE	TPMT	191	P51580
VSHPHPPSPVDPYLL	ZNF318	691	Q5VUA4
FHSPSHPPIVHPVYP	USP54	1591	Q70EL1
HPPIVHPVYPPSSSL	USP54	1596	Q70EL1
HPVYPPSSSLHVPLR	USP54	1601	Q70EL1
PTDPHLPYHLLPGAG	ZBTB3	416	Q9H5J0
VVHPKYHQGSGPILP	KLK10	116	O43240