Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of presynaptic cytosolic calcium ion concentration

CACNA1A P2RY4 CNR1

1.19e-0626173GO:0099509
GeneOntologyBiologicalProcessneuron cellular homeostasis

CACNA1A P2RY4 CNR1

4.25e-0584173GO:0070050
GeneOntologyBiologicalProcessregulation of cytosolic calcium ion concentration

CACNA1A P2RY4 CNR1

4.25e-0584173GO:0051480
GeneOntologyBiologicalProcessintracellular monoatomic cation homeostasis

CACNA1A P2RY4 STEAP3 CNR1 DMXL1

1.03e-04611175GO:0030003
GeneOntologyBiologicalProcessintracellular monoatomic ion homeostasis

CACNA1A P2RY4 STEAP3 CNR1 DMXL1

1.12e-04622175GO:0006873
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception of sound

STRCP1 STRC

1.60e-0423172GO:0050910
GeneOntologyBiologicalProcessmonoatomic cation homeostasis

CACNA1A P2RY4 STEAP3 CNR1 DMXL1

2.02e-04705175GO:0055080
GeneOntologyBiologicalProcessauditory receptor cell stereocilium organization

STRCP1 STRC

2.05e-0426172GO:0060088
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

CACNA1A P2RY4 STEAP3 CNR1 DMXL1

2.19e-04717175GO:0050801
GeneOntologyBiologicalProcessauditory receptor cell morphogenesis

STRCP1 STRC

2.93e-0431172GO:0002093
GeneOntologyBiologicalProcessauditory receptor cell development

STRCP1 STRC

4.90e-0440172GO:0060117
GeneOntologyBiologicalProcessintracellular chemical homeostasis

CACNA1A P2RY4 STEAP3 CNR1 DMXL1

5.23e-04866175GO:0055082
GeneOntologyBiologicalProcessneuron development

IQSEC1 CACNA1A CNR1 STRCP1 STRC FARP2

7.89e-041463176GO:0048666
GeneOntologyBiologicalProcessinner ear receptor cell stereocilium organization

STRCP1 STRC

8.60e-0453172GO:0060122
GeneOntologyBiologicalProcesscellular homeostasis

CACNA1A P2RY4 STEAP3 CNR1 DMXL1

9.23e-04981175GO:0019725
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception

STRCP1 STRC

9.94e-0457172GO:0050974
GeneOntologyBiologicalProcesssecretion by cell

GHRHR CACNA1A P2RY4 STEAP3 CNR1

1.33e-031064175GO:0032940
GeneOntologyBiologicalProcessinner ear auditory receptor cell differentiation

STRCP1 STRC

1.37e-0367172GO:0042491
GeneOntologyBiologicalProcessinorganic ion homeostasis

CACNA1A P2RY4 STEAP3 CNR1

1.43e-03622174GO:0098771
GeneOntologyBiologicalProcessepidermal cell differentiation

IL20 STRCP1 STRC

1.52e-03284173GO:0009913
GeneOntologyBiologicalProcessinner ear receptor cell development

STRCP1 STRC

1.62e-0373172GO:0060119
GeneOntologyBiologicalProcesssynaptic transmission, GABAergic

CACNA1A CNR1

1.67e-0374172GO:0051932
GeneOntologyBiologicalProcesssignal release

GHRHR CACNA1A P2RY4 CNR1

1.70e-03653174GO:0023061
GeneOntologyBiologicalProcessdetection of mechanical stimulus

STRCP1 STRC

1.71e-0375172GO:0050982
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

IQSEC1 CACNA1A P2RY4 CNR1

1.80e-03663174GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

IQSEC1 CACNA1A P2RY4 CNR1

1.81e-03664174GO:0099177
GeneOntologyBiologicalProcesshair cell differentiation

STRCP1 STRC

1.85e-0378172GO:0035315
GeneOntologyBiologicalProcessexport from cell

GHRHR CACNA1A P2RY4 STEAP3 CNR1

1.90e-031153175GO:0140352
GeneOntologyBiologicalProcessvesicle-mediated transport in synapse

IQSEC1 CACNA1A P2RY4

2.16e-03321173GO:0099003
GeneOntologyBiologicalProcesssecretion

GHRHR CACNA1A P2RY4 STEAP3 CNR1

2.45e-031221175GO:0046903
GeneOntologyBiologicalProcessregulation of secretion by cell

GHRHR CACNA1A P2RY4 CNR1

2.69e-03740174GO:1903530
GeneOntologyBiologicalProcesschemical homeostasis

CACNA1A P2RY4 STEAP3 CNR1 DMXL1

2.71e-031249175GO:0048878
GeneOntologyBiologicalProcessinner ear receptor cell differentiation

STRCP1 STRC

2.79e-0396172GO:0060113
GeneOntologyBiologicalProcessanatomical structure maturation

GHRHR CACNA1A FARP2

2.85e-03354173GO:0071695
GeneOntologyBiologicalProcessintracellular calcium ion homeostasis

CACNA1A P2RY4 CNR1

2.97e-03359173GO:0006874
GeneOntologyBiologicalProcessneuron projection development

IQSEC1 CACNA1A CNR1 STRCP1 STRC

3.07e-031285175GO:0031175
GeneOntologyBiologicalProcessmechanoreceptor differentiation

STRCP1 STRC

3.26e-03104172GO:0042490
GeneOntologyCellularComponent9+2 non-motile cilium

STRCP1 STRC

6.33e-0514182GO:0097732
GeneOntologyCellularComponentkinocilium

STRCP1 STRC

6.33e-0514182GO:0060091
GeneOntologyCellularComponentstereocilium tip

STRCP1 STRC

1.60e-0422182GO:0032426
GeneOntologyCellularComponentstereocilium

STRCP1 STRC

1.59e-0369182GO:0032420
GeneOntologyCellularComponentpresynaptic membrane

CACNA1A P2RY4 CNR1

1.62e-03277183GO:0042734
GeneOntologyCellularComponentpresynaptic active zone membrane

CACNA1A P2RY4

2.02e-0378182GO:0048787
GeneOntologyCellularComponentstereocilium bundle

STRCP1 STRC

2.07e-0379182GO:0032421
GeneOntologyCellularComponentglutamatergic synapse

IQSEC1 CACNA1A P2RY4 CNR1

4.57e-03817184GO:0098978
GeneOntologyCellularComponentpresynapse

IQSEC1 CACNA1A P2RY4 CNR1

6.09e-03886184GO:0098793
GeneOntologyCellularComponentpresynaptic active zone

CACNA1A P2RY4

6.44e-03141182GO:0048786
MousePhenoabnormal cochlear microphonics

STRCP1 STRC

1.41e-0418142MP:0004412
MousePhenoabnormal cochlear potential

STRCP1 STRC

1.58e-0419142MP:0006332
MousePhenoabnormal cochlear outer hair cell physiology

STRCP1 STRC

3.47e-0428142MP:0004434
MousePhenoabsent long-term depression

IQSEC1 CNR1

3.99e-0430142MP:0001899
MousePhenoincreased cerebral infarct size

CACNA1A CNR1

4.26e-0431142MP:0006060
MousePhenoabnormal cochlear hair cell physiology

STRCP1 STRC

7.11e-0440142MP:0004432
MousePhenoincreased susceptibility to ischemic brain injury

CACNA1A CNR1

7.11e-0440142MP:0003076
MousePhenoincreased response to brain injury

CACNA1A CNR1

7.11e-0440142MP:0014523
MousePhenoabsent distortion product otoacoustic emissions

STRCP1 STRC

7.47e-0441142MP:0004737
MousePhenodecreased vertical activity

GHRHR CACNA1A CNR1

9.76e-04203143MP:0002757
MousePhenoabnormal hair cell physiology

STRCP1 STRC

1.07e-0349142MP:0003879
DomainPH

IQSEC1 FARP2

2.04e-02278152SM00233
DomainPH_DOMAIN

IQSEC1 FARP2

2.05e-02279152PS50003
DomainPH_domain

IQSEC1 FARP2

2.07e-02280152IPR001849
Pubmed

Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.

STRCP1 STRC

2.53e-07218211687802
Pubmed

Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.

STRCP1 STRC

2.53e-07218234910522
Pubmed

Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.

STRCP1 STRC

7.59e-07318230801007
Pubmed

Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.

STRCP1 STRC

1.52e-06418218849963
Pubmed

An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.

STRCP1 STRC

2.53e-06518224920589
Pubmed

Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.

STRCP1 STRC

7.07e-06818221165971
Pubmed

Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.

STRCP1 STRC

1.39e-051118231776257
Pubmed

Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.

STRCP1 STRC

1.39e-051118231448880
Pubmed

Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.

STRCP1 STRC

3.42e-051718220856818
Pubmed

Dissociation of heterotrimeric g proteins in cells.

GHRHR P2RY4 CNR1

1.03e-0417918318577758
Pubmed

Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.

GHRHR P2RY4 CNR1

1.43e-0420018318240029
Pubmed

A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.

STRCP1 STRC

1.76e-043818238346162
Pubmed

BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.

STEAP3 FAM135B DMXL1

4.06e-0428518334369648
Cytoband15q15.3

STRCP1 STRC

4.33e-052518215q15.3
CytobandEnsembl 112 genes in cytogenetic band chr15q15

STRCP1 STRC

1.51e-03147182chr15q15
CytobandEnsembl 112 genes in cytogenetic band chr3p25

GALNT15 IQSEC1

1.67e-03155182chr3p25
DrugLY320135

CACNA1A CNR1

1.32e-0423172CID005311257
Druggeldanamycin; Up 200; 1uM; MCF7; HT_HG-U133A

ENTPD7 GHRHR P4HA2

2.85e-041761735588_UP
DrugEtilefrine hydrochloride [534-87-2]; Up 200; 18.4uM; HL60; HT_HG-U133A

IQSEC1 P2RY4 FARP2

3.10e-041811732930_UP
DrugSolasodine [126-17-0]; Up 200; 9.6uM; PC3; HT_HG-U133A

GHRHR P2RY4 CNR1

3.97e-041971734305_UP
DrugCarteolol hydrochloride [51781-21-6]; Down 200; 12.2uM; PC3; HT_HG-U133A

ENTPD7 GHRHR CACNA1A

3.97e-041971734096_DN
DrugQuipazine dimaleate salt [4774-24-7]; Up 200; 9uM; PC3; HT_HG-U133A

ENTPD7 GHRHR CACNA1A

3.97e-041971735887_UP
DrugPhenethicillin potassium salt [132-93-4]; Down 200; 10uM; MCF7; HT_HG-U133A

GHRHR P2RY4 FARP2

3.97e-041971736105_DN
DrugNystatine [1400-61-9]; Down 200; 4.4uM; HL60; HT_HG-U133A

ENTPD7 IQSEC1 GHRHR

4.03e-041981732500_DN
DrugDipyrone [5907-38-0]; Up 200; 12uM; HL60; HT_HG-U133A

IQSEC1 GHRHR FARP2

4.03e-041981732175_UP
Drugfluphenazine dihydrochloride; Up 200; 10uM; HL60; HT_HG-U133A

IQSEC1 GHRHR FARP2

4.03e-041981736196_UP
DrugNisoxetine hydrochloride [57754-86-6]; Down 200; 13uM; HL60; HT_HG-U133A

ENTPD7 CACNA1A STEAP3

4.03e-041981733117_DN
DrugFlucloxacillin sodium [1847-24-1]; Down 200; 8.4uM; HL60; HT_HG-U133A

IQSEC1 GHRHR FARP2

4.09e-041991733128_DN
DrugMeropenem [96036-03-2]; Up 200; 10.4uM; HL60; HT_HG-U133A

ENTPD7 GHRHR CNR1

4.15e-042001736141_UP
DrugRilmenidine hemifumarate [54187-04-1]; Down 200; 8.4uM; MCF7; HT_HG-U133A

ENTPD7 GHRHR CACNA1A

4.15e-042001736512_DN
DrugI06-1821

GHRHR CNR1

5.10e-0445172CID005464109
Drugmethyl salicylate

CNR1 FARP2

6.55e-0451172CID000004133
Drugclonidine

GHRHR P2RY4 CNR1

7.05e-04240173CID000002803
Diseaseautosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)

STRCP1 STRC

3.12e-072172DOID:0110471 (implicated_via_orthology)
DiseaseAlzheimer disease, gastroesophageal reflux disease

GALNT15 CACNA1A FAM135B

2.86e-04228173EFO_0003948, MONDO_0004975
Diseaseneuritic plaque measurement

GALNT15 CACNA1A FAM135B

9.86e-04349173EFO_0006798

Protein segments in the cluster

PeptideGeneStartEntry
PLRRLCHYILNLRYF

CACNA1A

1231

O00555
YLRTHPLLLRRHFGS

DMXL1

1816

Q9Y485
FLYLLRLRRIHHRQT

ENTPD7

566

Q9NQZ7
LSLPHRRLVCYCRLF

IQSEC1

746

Q6DN90
RYRHRPCRLQFLLLL

GALNT15

6

Q8N3T1
LCRRYHASYRHRPLP

C1orf210

56

Q8IVY1
PTHRLLCYLLHLRFR

FAM214B

476

Q7L5A3
HELLCQNPLHRLRYL

RSKR

336

Q96LW2
LTPRRQKRLFCRYHH

P4HA2

301

O15460
VHRYLGICHPLRALR

P2RY4

131

P51582
ILHSRSLRCRPSYHF

CNR1

141

P21554
LVALRRLHCPRNYVH

GHRHR

151

Q02643
PANRCCLLRHLLRLY

IL20

76

Q9NYY1
HRDLCLLLLHAYRGL

FAM135B

241

Q49AJ0
LLLLHAYRGLRLHFL

FAM135B

246

Q49AJ0
LHYRLLLRRLCGHYS

FARP2

686

O94887
HPTRLHYLLRLLTFL

STRC

616

Q7RTU9
HALYSFCLPLRRAHR

STEAP3

316

Q658P3
HPTRLHYLLRLLTFL

STRCP1

616

A6NGW2
CVYLLHLLRRHKHRP

PVRIG

186

Q6DKI7