Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR4C46 GPR55 OR6Y1 OR51D1 GALR1 OR2L3 MAS1L OR10H3 OR11H7 OR6K6	1.11e-05	884	42	10	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR4C46 OR6Y1 OR51D1 OR2L3 OR10H3 OR11H7 OR6K6	2.92e-05	431	42	7	GO:0004984
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR4C46 GPR55 OR6Y1 OR51D1 GALR1 OR2L3 MAS1L OR10H3 OR11H7 OR6K6	3.93e-04	1353	42	10	GO:0004888
GeneOntologyMolecularFunction	organic hydroxy compound transmembrane transporter activity	SLC2A13 SLC10A1 SLC22A3	4.29e-04	70	42	3	GO:1901618
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	ANO1 OR4C46 OR6Y1 OR51D1 OR2L3 OR10H3 OR11H7 OR6K6	2.32e-05	582	43	8	GO:0050906
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR4C46 OR6Y1 OR51D1 OR2L3 OR10H3 OR11H7 OR6K6	2.83e-05	432	43	7	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR4C46 OR6Y1 OR51D1 OR2L3 OR10H3 OR11H7 OR6K6	4.52e-05	465	43	7	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR4C46 OR6Y1 OR51D1 OR2L3 OR10H3 OR11H7 OR6K6	5.89e-05	485	43	7	GO:0050907
GeneOntologyBiologicalProcess	regulation of Rab protein signal transduction	DENND4A MADD	6.33e-05	6	43	2	GO:0032483
GeneOntologyBiologicalProcess	glycoprotein biosynthetic process	ARFGEF1 TMTC1 DSEL PLOD1 DERL3 TMEM106A	9.15e-05	357	43	6	GO:0009101
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR4C46 OR6Y1 OR51D1 OR2L3 OR10H3 OR11H7 OR6K6	9.57e-05	524	43	7	GO:0009593
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	ANO1 OR4C46 GPR55 OR6Y1 OR51D1 GALR1 OR2L3 MAS1L OR10H3 OR11H7 OR6K6	9.98e-05	1395	43	11	GO:0007186
GeneOntologyBiologicalProcess	detection of stimulus	ANO1 OR4C46 OR6Y1 OR51D1 OR2L3 OR10H3 OR11H7 OR6K6	1.06e-04	722	43	8	GO:0051606
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR4C46 OR6Y1 OR51D1 OR2L3 OR10H3 OR11H7 OR6K6	1.25e-04	547	43	7	GO:0007606
GeneOntologyBiologicalProcess	glycoprotein metabolic process	ARFGEF1 TMTC1 DSEL PLOD1 DERL3 TMEM106A	2.52e-04	430	43	6	GO:0009100
Domain	GPCR_Rhodpsn_7TM	OR4C46 GPR55 OR6Y1 OR51D1 GALR1 OR2L3 MAS1L OR10H3 OR6K6	1.17e-05	670	41	9	IPR017452
Domain	7tm_1	OR4C46 GPR55 OR6Y1 OR51D1 GALR1 OR2L3 MAS1L OR10H3 OR6K6	1.27e-05	677	41	9	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR4C46 GPR55 OR6Y1 OR51D1 GALR1 OR2L3 MAS1L OR10H3 OR6K6	1.39e-05	685	41	9	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR4C46 GPR55 OR6Y1 OR51D1 GALR1 OR2L3 MAS1L OR10H3 OR6K6	1.49e-05	691	41	9	PS50262
Domain	GPCR_Rhodpsn	OR4C46 GPR55 OR6Y1 OR51D1 GALR1 OR2L3 MAS1L OR10H3 OR6K6	1.51e-05	692	41	9	IPR000276
Domain	Olfact_rcpt	OR4C46 OR6Y1 OR51D1 OR2L3 OR10H3 OR6K6	2.01e-04	393	41	6	IPR000725
Domain	MIT	SNX15 RPS6KC1	2.09e-04	10	41	2	SM00745
Domain	MIT	SNX15 RPS6KC1	2.09e-04	10	41	2	PF04212
Domain	-	SNX15 RPS6KC1	3.61e-04	13	41	2	1.20.58.280
Domain	uDENN	DENND4A MADD	4.21e-04	14	41	2	SM00800
Domain	MIT	SNX15 RPS6KC1	4.21e-04	14	41	2	IPR007330
Domain	uDENN	DENND4A MADD	4.85e-04	15	41	2	PF03456
Domain	DENN	DENND4A MADD	5.53e-04	16	41	2	PF02141
Domain	UDENN	DENND4A MADD	5.53e-04	16	41	2	PS50946
Domain	DDENN	DENND4A MADD	5.53e-04	16	41	2	PS50947
Domain	dDENN_dom	DENND4A MADD	5.53e-04	16	41	2	IPR005112
Domain	uDENN_dom	DENND4A MADD	5.53e-04	16	41	2	IPR005113
Domain	dDENN	DENND4A MADD	5.53e-04	16	41	2	PF03455
Domain	DENN	DENND4A MADD	5.53e-04	16	41	2	SM00799
Domain	DENN	DENND4A MADD	5.53e-04	16	41	2	PS50211
Domain	DENN_dom	DENND4A MADD	5.53e-04	16	41	2	IPR001194
Domain	dDENN	DENND4A MADD	5.53e-04	16	41	2	SM00801
Domain	SUGAR_TRANSPORT_2	SLC2A13 SLC22A3	6.26e-04	17	41	2	PS00217
Domain	SUGAR_TRANSPORT_1	SLC2A13 SLC22A3	1.26e-03	24	41	2	PS00216
Domain	Sugar_transporter_CS	SLC2A13 SLC22A3	2.24e-03	32	41	2	IPR005829
Domain	PX	SNX15 RPS6KC1	4.20e-03	44	41	2	SM00312
Domain	PX	SNX15 RPS6KC1	5.18e-03	49	41	2	PF00787
Domain	PX	SNX15 RPS6KC1	5.39e-03	50	41	2	PS50195
Domain	-	SNX15 RPS6KC1	5.60e-03	51	41	2	3.30.1520.10
Domain	Phox	SNX15 RPS6KC1	5.82e-03	52	41	2	IPR001683
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR4C46 OR6Y1 OR51D1 OR2L3 OR10H3 OR11H7 OR6K6	2.13e-05	417	30	7	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR4C46 OR6Y1 OR51D1 OR2L3 OR10H3 OR6K6	1.44e-04	389	30	6	M14091
Pathway	REACTOME_SENSORY_PERCEPTION	OR4C46 OR6Y1 OR51D1 OR2L3 OR10H3 OR11H7 OR6K6	3.02e-04	636	30	7	M41834
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR4C46 OR6Y1 OR51D1 OR2L3 OR10H3 OR11H7 OR6K6	2.03e-07	343	43	7	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR4C46 OR6Y1 OR51D1 OR2L3 OR10H3 OR11H7 OR6K6	2.15e-07	346	43	7	14611657
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR4C46 OR6Y1 OR51D1 OR2L3 OR10H3 OR11H7	3.75e-06	340	43	6	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR4C46 OR6Y1 OR51D1 OR2L3 OR10H3 OR11H7	3.75e-06	340	43	6	11802173
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	PDXDC1 ARFGEF1 DENND4A NUP155 MADD RPS6KC1	3.48e-05	504	43	6	34432599
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	POLR1A NUP155 PLOD1 DHX38 RPS6KC1	2.05e-04	440	43	5	34244565
Pubmed	The human olfactory receptor gene family.	OR6Y1 OR51D1 OR10H3 OR11H7 OR6K6	5.28e-04	541	43	5	14983052
Pubmed	Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.	DSEL SACS	7.23e-04	32	43	2	25189868
Pubmed	Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.	DENND4A MADD	9.67e-04	37	43	2	20937701
Pubmed	Exome sequencing supports a de novo mutational paradigm for schizophrenia.	OR4C46 CFAP65	1.13e-03	40	43	2	21822266
Cytoband	6q25.3	ZDHHC14 SLC22A3	4.44e-04	33	43	2	6q25.3
Cytoband	1q23.1	OR6Y1 OR6K6	8.64e-04	46	43	2	1q23.1
GeneFamily	Rhomboid family	RHBDD1 DERL3	2.56e-04	14	31	2	926
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND4A MADD	8.33e-04	25	31	2	504
GeneFamily	Olfactory receptors, family 6	OR6Y1 OR6K6	3.44e-03	51	31	2	153
GeneFamily	G protein-coupled receptors, Class A orphans	GPR55 MAS1L	7.88e-03	78	31	2	262
Disease	phospholipids:total lipids ratio	PDXDC1 SLC22A3 MADD DHX38	1.85e-04	227	37	4	EFO_0020946
Disease	Alzheimer disease, APOE carrier status	ANO1 GALR1 DSCAM	2.54e-04	98	37	3	EFO_0007659, MONDO_0004975
Disease	triglyceride measurement, body mass index	PDXDC1 SLC22A3	2.58e-04	19	37	2	EFO_0004340, EFO_0004530
Disease	Drug Use Disorders	SLC2A13 DSCAM SLC22A3	4.07e-04	115	37	3	C0013222
Disease	Drug Dependence	SLC2A13 DSCAM SLC22A3	4.07e-04	115	37	3	C1510472
Disease	Drug habituation	SLC2A13 DSCAM SLC22A3	4.07e-04	115	37	3	C0013170
Disease	Substance Dependence	SLC2A13 DSCAM SLC22A3	4.07e-04	115	37	3	C0038580
Disease	Substance Use Disorders	SLC2A13 DSCAM SLC22A3	4.07e-04	115	37	3	C0038586
Disease	Substance-Related Disorders	SLC2A13 DSCAM SLC22A3	4.07e-04	115	37	3	C0236969
Disease	Drug abuse	SLC2A13 DSCAM SLC22A3	4.07e-04	115	37	3	C0013146
Disease	Organic Mental Disorders, Substance-Induced	SLC2A13 DSCAM SLC22A3	4.07e-04	115	37	3	C0029231
Disease	Prescription Drug Abuse	SLC2A13 DSCAM SLC22A3	4.07e-04	115	37	3	C4316881
Disease	Substance abuse problem	SLC2A13 DSCAM SLC22A3	4.17e-04	116	37	3	C0740858
Disease	uric acid measurement	SLC10A1 POLR1A DSCAM PCNX3 SLC22A3	9.37e-04	610	37	5	EFO_0004761
Disease	lean body mass	PDXDC1 ANO1 GALR1 SLC22A3	1.27e-03	379	37	4	EFO_0004995
Disease	total lipids in lipoprotein particles measurement	SLC22A3 DHX38	1.66e-03	48	37	2	EFO_0022309
Disease	free cholesterol to total lipids in small HDL percentage	PDXDC1 MADD	1.88e-03	51	37	2	EFO_0022285
Disease	free cholesterol to total lipids in medium HDL percentage	PDXDC1 MADD	2.59e-03	60	37	2	EFO_0022282
Disease	anxiety	DSCAM MADD DNAH1	2.74e-03	223	37	3	EFO_0005230
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	PDXDC1 SLC22A3 DNAH1	2.77e-03	224	37	3	EFO_0004530, EFO_0008317
Disease	total cholesterol measurement, very low density lipoprotein cholesterol measurement	PDXDC1 SLC22A3 DHX38	2.77e-03	224	37	3	EFO_0004574, EFO_0008317
Disease	triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	PDXDC1 SLC22A3 DHX38	2.81e-03	225	37	3	EFO_0008317, EFO_0020947
Disease	phospholipids in very large HDL measurement	PDXDC1 MADD	3.12e-03	66	37	2	EFO_0022298
Disease	total lipids in very large HDL measurement	PDXDC1 MADD	3.12e-03	66	37	2	EFO_0022312
Disease	dehydroepiandrosterone sulphate measurement	TMTC1 CYP3A43	3.31e-03	68	37	2	EFO_0007001
Disease	very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	PDXDC1 SLC22A3 DHX38	3.33e-03	239	37	3	EFO_0008317, EFO_0020945
Disease	cholesterol in very large HDL measurement	PDXDC1 MADD	3.40e-03	69	37	2	EFO_0022229
Disease	metabolite measurement, diet measurement	PDXDC1 SLC22A3	3.60e-03	71	37	2	EFO_0004725, EFO_0008111
Disease	total lipids in large HDL	PDXDC1 MADD	3.90e-03	74	37	2	EFO_0022189
Disease	cholesteryl ester measurement	PDXDC1 SLC22A3 MADD	4.08e-03	257	37	3	EFO_0010351
Disease	free cholesterol in large HDL measurement	PDXDC1 MADD	4.44e-03	79	37	2	EFO_0022157
Disease	cholesterol in large HDL measurement	PDXDC1 MADD	4.55e-03	80	37	2	EFO_0021900
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	PDXDC1 MADD DNAH1	4.97e-03	276	37	3	EFO_0004612, EFO_0020943

Protein segments in the cluster

Peptide	Gene	Start	Entry
PQGIFAPEFFFKVLV	CATSPERG	1021	Q6ZRH7
RGETFPPFIVFKIFL	CXorf58	106	Q96LI9
FFLRIGVVFQISQPP	ARFGEF1	1826	Q9Y6D6
VNFFGLLTFQAPFLP	DERL3	141	Q96Q80
FFPPSRIGLFLFILI	OR2L3	16	Q8NG85
PFCGNIFLPFLNIEI	DENND4A	1481	Q7Z401
RNLPHLFLFFLFVGP	PCDH20	41	Q8N6Y1
FPRPVVAFQAGSFLA	MADD	516	Q8WXG6
IPFAFFLPELIFGFL	MALL	26	Q13021
ELFPPFAKGIVFGRF	RPS6KC1	76	Q96S38
KFFFTVIPQPIFLSP	CFAP65	186	Q6ZU64
FPFVFLLGLLPQVNT	PCNX3	911	Q9H6A9
IQILFIFQLPFCGPN	OR4C46	156	A6NHA9
ALTRGFVFFFPLPFI	OR51D1	161	Q8NGF3
VFRFFQELPGSDPVF	PDXDC1	391	Q6P996
FGFVTLFVASFPLAP	ANO1	736	Q5XXA6
VFFPLEVFGFLLPMG	GPR55	181	Q9Y2T6
VVFFIPDFLAILSPF	MAS1L	141	P35410
AGTPRFFPLDFIVQF	NUP155	1256	O75694
GVFIEQPTPFVSLFF	PLOD1	291	Q02809
GFSAFPQQLLPVLFL	OR10H3	16	O60404
NVAFPPEVIGPLFFF	SLC10A1	271	Q14973
EFGVFPLTPASFLFR	GALR1	271	P47211
FGPPLGRNFIFFIDD	DNAH1	2281	Q9P2D7
FPFLTPVFEALNIGL	CYP3A43	226	Q9HB55
GLRFAVNNIPFPVDF	LAMB4	606	A4D0S4
GVVVAFAPNFPVFVI	SLC22A3	196	O75751
FAPNFPVFVIFRFLQ	SLC22A3	201	O75751
FINGNFPGTFFRFPL	SACS	261	Q9NZJ4
FPFGFKFNIAVGLIL	DSEL	766	Q8IZU8
VVIFAACVFFLVGPP	OR2A1;	196	Q8NGT9
FFIFQLPFCGPNIID	OR11H7	161	Q8NGC8
IAVTFVILAPFFNPI	OR6K6	301	Q8NGW6
AVPAVIQFFGFLFLP	SLC2A13	246	Q96QE2
PFEFPRFSIGQRVFI	DSCAM	601	O60469
VFFLFPRSVIVQPAG	TMEM106A	111	Q96A25
RFNPSVFFLDFLVVP	POLR1A	291	O95602
GFVNILGFPVPNRFA	RHBDD1	161	Q8TEB9
GFPTRPAFQLLFFSI	OR6Y1	21	Q8NGX8
VTFPDVPLGIFLFCV	TMEM175	131	Q9BSA9
VFPFIPASNLFFRVG	TMTC1	391	Q8IUR5
FPAFPRAQVFGRFEA	SNX15	76	Q9NRS6
FLGLFPVFTISTNFP	TMEM104	356	Q8NE00
KFAAFFGNVPIFHIP	DHX38	691	Q92620
TPAIPAVAGILFFFV	ZDHHC14	91	Q8IZN3