Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domain-

CHD3 SSRP1

4.76e-03553521.10.30.10
DomainHMG_box_dom

CHD3 SSRP1

6.59e-0365352IPR009071
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

GEMIN4 MAGEA1 TRIM25 SSRP1 RIOK2 MRPL22 CREBBP AQR WDR47

5.62e-06135335929467282
Pubmed

Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation.

CREBBP NLK

9.82e-06535215308626
Pubmed

Nemo-like kinase suppresses a wide range of transcription factors, including nuclear factor-kappaB.

CREBBP NLK

9.82e-06535214720327
Pubmed

The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3.

CREBBP NLK

1.47e-05635216055500
Pubmed

The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A.

NCAPD3 PTPA

1.47e-05635219915589
Pubmed

Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactions.

CSHL1 CREBBP

1.47e-05635222890843
Pubmed

LRP16 integrates into NF-κB transcriptional complex and is required for its functional activation.

MACROD1 CREBBP

2.06e-05735221483817
Pubmed

Oxidative stress-dependent regulation of Forkhead box O4 activity by nemo-like kinase.

CREBBP NLK

3.53e-05935220874444
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

RALGDS NCAPD3 CHD3 ZBTB11 RIOK2 AQR

4.26e-0565035638777146
Pubmed

Histone modifications defining active genes persist after transcriptional and mitotic inactivation.

SSRP1 CREBBP

8.89e-051435215616580
Pubmed

Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development.

CSHL1 CREBBP

1.33e-041735212464179
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

CHD3 SSRP1 AQR

1.54e-0410335332744500
Pubmed

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.

CHD3 TRIM25 SSRP1 AQR

1.56e-0427135432433965
Pubmed

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.

GEMIN4 SSRP1

2.91e-042535215385968
Pubmed

Functional proteomics mapping of a human signaling pathway.

FMNL3 CHD3 ZBTB11 CREBBP ZYX

2.97e-0459135515231748
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

GEMIN4 NCAPD3 CHD3 AQR

3.74e-0434135432971831
Pubmed

SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.

GEMIN4 NCAPD3 TRIM25

4.65e-0415035330154076
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

CHD3 PTPA TRIM25 SSRP1 CREBBP AQR

4.76e-04101435632416067
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

CHD3 SSRP1 CREBBP

5.31e-0415735330186101
Pubmed

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.

PTPA CREBBP

5.41e-043435230894540
Pubmed

Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.

CHD3 CREBBP

6.76e-043835228680062
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

NCAPD3 CHD3 TRIM25 SSRP1 CREBBP ZYX

7.41e-04110335634189442
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

NCAPD3 CHD3 SSRP1 ZBTB11 AQR

9.22e-0475935535915203
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

TRIM25 SSRP1 ZBTB11 AQR

9.70e-0444035434244565
InteractionJADE1 interactions

TRIM25 SSRP1 RIOK2 CREBBP

9.43e-0677354int:JADE1
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

GEMIN4 CREBBP ZYX GOLGA1 ENOX2

7.01e-061763551212_DN
DiseaseSezary Syndrome

CHD3 CREBBP

4.44e-0427342C0036920
Diseasepreterm premature rupture of the membranes, spontaneous preterm birth

TTC21B FMNL3

4.78e-0428342EFO_0006917, MONDO_0012511
DiseaseAlzheimer disease, polygenic risk score

DOCK3 SSRP1 ABCD2 HYDIN

4.45e-03586344EFO_0030082, MONDO_0004975
Diseasebone density

TTC21B COLEC10 CSHL1

9.98e-03388343EFO_0003923

Protein segments in the cluster

PeptideGeneStartEntry
HRKDKMLYITCFREI

TTC21B

701

Q7Z4L5
RMFYHKPKYALLDEC

ABCD2

621

Q9UBJ2
MLDKAFAERIIHDYK

CREBBP

1506

Q92793
YGLLHCFRKDMDKVE

CSHL1

191

Q14406
ECHLTMYFVCEFIKK

COLEC10

261

Q9Y6Z7
KVHYCERFIELMIDL

AQR

246

O60306
AEMLESVIKNYKHCF

MAGEA1

126

P43355
EYLKHVVLKFMSCRE

GOLGA1

696

Q92805
FIFLCMETHYEKVLK

GOLGA7B

86

Q2TAP0
TFCELHELKKFRKMF

KCNK1

266

O00180
KKNFCHIRFAEEYMV

ENOX2

161

Q16206
CIRFRLMTEKYFKDH

KLHL41

221

O60662
RVFRELKMLCFFKHD

NLK

181

Q9UBE8
CFHRDKNIKIYDMYV

PRSS38

101

A1L453
KEYNKCEMLDHFDII

HYDIN

1521

Q4G0P3
INKEEMYIRYIHKLC

DOCK3

1231

Q8IZD9
EFKAYVSLFMRHLCE

CHD3

1451

Q12873
VCKELHRFEKLMEYF

FMNL3

296

Q8IVF7
EEHYFCKDFVRLKKI

MACROD1

111

Q9BQ69
LMDAELFKKVVPYHC

RALGDS

396

Q12967
LIKKYDQMAIFHCLF

KCNMB3

201

Q9NPA1
MKEECLREDLKFYFM

MCOLN2

36

Q8IZK6
MEKVYCHYFVKLVEG

MRPL22

161

Q9NWU5
SDFFKTHYRLELMEK

SSRP1

86

Q08945
RMKIYKFLLEHFTDE

NCAPD3

1096

P42695
LECMEKFDKKRFRYI

WDR47

71

O94967
FHRDYVPCKIMLEKD

ZBTB11

936

O95625
ENHKDYMFLECILFI

PTPA

281

Q15257
RLEMHFKLKEDYEKI

SYCP1

236

Q15431
KVHLMYKFRVDFTEA

TRIM25

596

Q14258
YFDRDVKCIKDFFMK

RIOK2

261

Q9BVS4
VKCIKDFFMKRFSYE

RIOK2

266

Q9BVS4
VRVVALDKNFHMKCY

ZYX

521

Q15942
VKRKHTKEFEFYCMA

ZNF407

1036

Q9C0G0
DRHMEVCYIFASEKK

GEMIN4

416

P57678
EIYKRHCEEKFVMDM

LRRIQ3

576

A6PVS8