Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesspositive regulation of cell-cell adhesion mediated by cadherin

FOXA1 FOXA2 WNT3A

2.91e-05111183GO:2000049
GeneOntologyBiologicalProcessregulation of dopaminergic neuron differentiation

FOXA1 FOXA2 WNT3A

3.87e-05121183GO:1904338
MousePhenoincreased circulating LDL cholesterol level

CT45A6 CT45A1 CT45A10 CT45A2 CT45A7 CT45A9 CT45A3

9.12e-0780927MP:0000182
MousePhenoincreased circulating HDL cholesterol level

IL12A CT45A6 CT45A1 RBL2 CT45A10 CT45A2 CT45A7 CT45A9 CT45A3

2.63e-05238929MP:0001556
MousePhenoincreased lipid level

IL12A CT45A6 CT45A1 RBL2 CT45A10 RRM2B CT45A2 FOXA2 CT45A7 PCTP CT45A9 CT45A3 WNT3A TTC17 LIPI CEP19 KIF2C

3.25e-058479217MP:0014460
MousePhenoabnormal circulating LDL cholesterol level

CT45A6 CT45A1 CT45A10 CT45A2 CT45A7 CT45A9 CT45A3

9.83e-05163927MP:0000181
MousePhenoincreased cholesterol level

IL12A CT45A6 CT45A1 RBL2 CT45A10 RRM2B CT45A2 CT45A7 PCTP CT45A9 CT45A3 TTC17

1.07e-045029212MP:0003982
MousePhenoabnormal cholesterol homeostasis

IL12A CT45A6 CT45A1 COPG1 RBL2 CT45A10 RRM2B DOCK9 CT45A2 FOXA1 CT45A7 CCKAR PCTP CT45A9 CT45A3 PIK3CB TTC17

1.13e-049369217MP:0005278
MousePhenoincreased sterol level

IL12A CT45A6 CT45A1 RBL2 CT45A10 RRM2B CT45A2 CT45A7 PCTP CT45A9 CT45A3 TTC17

1.13e-045059212MP:0012226
MousePhenoabnormal circulating non-HDL cholesterol level

CT45A6 CT45A1 CT45A10 CT45A2 CT45A7 CT45A9 CT45A3

1.82e-04180927MP:0020151
MousePhenoincreased circulating cholesterol level

IL12A CT45A6 CT45A1 RBL2 CT45A10 RRM2B CT45A2 CT45A7 CT45A9 CT45A3 TTC17

2.24e-044639211MP:0005178
MousePhenodecreased prepulse inhibition

ERCC3 ITSN1 SLITRK4 IFI44 ZMYM2 EDNRA DHX15 SETD2 PBRM1 LRFN2 CEP19

2.28e-044649211MP:0009142
DomainINT_SG_DDX_CT_C

CT45A1 CT45A10 CT45A7 CT45A9 CT45A3

4.28e-1081145PF15300
DomainINT_SG_DDX_CT_C

CT45A1 CT45A10 CT45A7 CT45A9 CT45A3

4.28e-1081145IPR029307
DomainFork-head_N

FOXA1 FOXA2

1.10e-0431142IPR013638
DomainLatrophilin

ADGRL1 ADGRL3

1.10e-0431142PF02354
DomainForkhead_box_C

FOXA1 FOXA2

1.10e-0431142IPR018533
DomainForkhead_N

FOXA1 FOXA2

1.10e-0431142PF08430
DomainHNF_C

FOXA1 FOXA2

1.10e-0431142PF09354
DomainGPCR_2_latrophilin_rcpt_C

ADGRL1 ADGRL3

1.10e-0431142IPR003334
DomainRmlC_Cupin

CT45A1 CT45A2 CT45A3

1.17e-04161143IPR011051
DomainUbiquitin-rel_dom

MYO7A MYO7B SF3A1 SACS PIK3CB SUMO1 RAPGEF2

1.36e-041841147IPR029071
Domain5peptide_repeat

KCTD9 SV2C

2.20e-0441142IPR001646
DomainClathrin_a/coatomer_app_sub_C

COPG1 AP2A1

2.20e-0441142IPR015873
Domain-

COPG1 AP2A1

2.20e-04411423.30.310.30
DomainTFIIA_a-hlx

GTF2A1L CEP19

2.20e-0441142IPR009083
DomainARM-type_fold

MON2 COPG1 DOCK8 DOCK9 PPP4R4 PPP2R1A AP2A1 PIK3CB PKP1

2.34e-043391149IPR016024
DomainARM-like

MON2 COPG1 DOCK8 ATAD2 PPP4R4 PPP2R1A AP2A1 PKP1

2.52e-042701148IPR011989
DomainGal_Lectin

ADGRL1 ADGRL3

3.65e-0451142PF02140
DomainGPCR_2_latrophilin

ADGRL1 ADGRL3

3.65e-0451142IPR003924
DomainLectin_gal-bd_dom

ADGRL1 ADGRL3

3.65e-0451142IPR000922
DomainSUEL_LECTIN

ADGRL1 ADGRL3

3.65e-0451142PS50228
Domain-

MON2 COPG1 ATAD2 PPP4R4 PPP2R1A AP2A1 PKP1

4.28e-0422211471.25.10.10
DomainDUF3398

DOCK8 DOCK9

5.45e-0461142PF11878
DomainDOCK_C/D_N

DOCK8 DOCK9

5.45e-0461142IPR021816
DomainCoatomer/calthrin_app_sub_C

COPG1 AP2A1

1.01e-0381142IPR009028
DomainMYTH4

MYO7A MYO7B

1.29e-0391142PS51016
DomainMyTH4

MYO7A MYO7B

1.29e-0391142SM00139
DomainMyTH4_dom

MYO7A MYO7B

1.29e-0391142IPR000857
DomainMyTH4

MYO7A MYO7B

1.29e-0391142PF00784
DomainMyosin_head_motor_dom

MYH8 MYO7A MYO7B

1.60e-03381143IPR001609
DomainMYOSIN_MOTOR

MYH8 MYO7A MYO7B

1.60e-03381143PS51456
DomainMyosin_head

MYH8 MYO7A MYO7B

1.60e-03381143PF00063
DomainMYSc

MYH8 MYO7A MYO7B

1.60e-03381143SM00242
DomainDHR-1_domain

DOCK8 DOCK9

1.96e-03111142IPR027007
DomainDHR_2

DOCK8 DOCK9

1.96e-03111142PS51651
DomainDHR_1

DOCK8 DOCK9

1.96e-03111142PS51650
DomainDHR-2

DOCK8 DOCK9

1.96e-03111142PF06920
DomainDOCK

DOCK8 DOCK9

1.96e-03111142IPR026791
DomainGAIN_dom_N

ADGRL1 ADGRL3

1.96e-03111142IPR032471
DomainDOCK_C

DOCK8 DOCK9

1.96e-03111142IPR010703
DomainDOCK-C2

DOCK8 DOCK9

1.96e-03111142PF14429
DomainDHR-2

DOCK8 DOCK9

1.96e-03111142IPR027357
DomainGAIN

ADGRL1 ADGRL3

1.96e-03111142PF16489
DomainCoatomer/clathrin_app_Ig-like

COPG1 AP2A1

2.34e-03121142IPR013041
DomainOLF

ADGRL1 ADGRL3

2.76e-03131142PF02191
DomainOLF

ADGRL1 ADGRL3

2.76e-03131142PS51132
DomainOlfac-like_dom

ADGRL1 ADGRL3

2.76e-03131142IPR003112
DomainOLF

ADGRL1 ADGRL3

2.76e-03131142SM00284
DomainTF_fork_head_CS_2

FOXA1 FOXA2 FOXI1

2.78e-03461143IPR030456
Domainubiquitin

SF3A1 SACS SUMO1

2.95e-03471143PF00240
DomainTF_fork_head_CS_1

FOXA1 FOXA2 FOXI1

2.95e-03471143IPR018122
DomainFerritin-like_SF

RRM2B SETD2

3.20e-03141142IPR009078
DomainFH

FOXA1 FOXA2 FOXI1

3.33e-03491143SM00339
DomainFORK_HEAD_1

FOXA1 FOXA2 FOXI1

3.33e-03491143PS00657
DomainFORK_HEAD_2

FOXA1 FOXA2 FOXI1

3.33e-03491143PS00658
DomainFork_head_dom

FOXA1 FOXA2 FOXI1

3.33e-03491143IPR001766
DomainFORK_HEAD_3

FOXA1 FOXA2 FOXI1

3.33e-03491143PS50039
DomainForkhead

FOXA1 FOXA2 FOXI1

3.33e-03491143PF00250
DomainClathrin/coatomer_adapt-like_N

COPG1 AP2A1

3.68e-03151142IPR002553
DomainAdaptin_N

COPG1 AP2A1

3.68e-03151142PF01602
DomainUBIQUITIN_2

SF3A1 SACS SUMO1

4.38e-03541143PS50053
DomainHEAT_type_2

PPP4R4 PPP2R1A

4.73e-03171142IPR021133
DomainUbiquitin_dom

SF3A1 SACS SUMO1

5.35e-03581143IPR000626
DomainP-loop_NTPase

MYH8 ERCC3 MYO7A MYO7B HS6ST2 NAIP IFI44 SRCAP ATAD2 DHX15 RHOBTB2 KIF2C

5.62e-0384811412IPR027417
Pubmed

Identification of cancer/testis-antigen genes by massively parallel signature sequencing.

CT45A6 CT45A1 CT45A10 CT45A2 CT45A7 CT45A9 CT45A8 CT45A3 CT45A5

4.25e-1915127915905330
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

COPG1 SF3A1 CHAF1A ZMYM2 SRCAP INTS3 PPP2R1A PBRM1 SUMO1 CPSF2 KIF2C

4.23e-083321271132786267
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

SF3A1 CHAF1A ZMYM2 SRCAP INTS3 UBN2 ITPR3 DHX15 LIG3 PPP2R1A SETD2 PBRM1 TMTC3 AP2A1 SUMO1 CPSF2 NAIF1 KIF2C

1.17e-0612941271830804502
Pubmed

Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter.

FOXA1 FOXA2 FOXI1

1.65e-06712737958446
Pubmed

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.

NCKAP1 SF3A1 RPS29 ATAD2 LIG3 PPP2R1A AP2A1 SACS SUMO1 CPSF2

2.29e-064001271035013556
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

NCKAP1 COPG1 RBL2 SF3A1 CHAF1A ZMYM2 FOXA1 FOXA2 INTS3 LIG3 PKP1 CPSF2 FOXI1 KIF2C

3.24e-068571271425609649
Pubmed

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.

MON2 RAPGEF6 ITSN1 AP2A1

4.94e-0631127425838543
Pubmed

Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function.

FOXA1 FOXA2 PLCB2

7.68e-0611127334009125
Pubmed

Latrophilin receptors: novel bronchodilator targets in asthma.

ADGRL1 ADGRL3

1.32e-052127227325752
Pubmed

Foxa1 and Foxa2 interact with the androgen receptor to regulate prostate and epididymal genes differentially.

FOXA1 FOXA2

1.32e-052127216467259
Pubmed

Pioneer Factors FOXA1 and FOXA2 Assist Selective Glucocorticoid Receptor Signaling in Human Endometrial Cells.

FOXA1 FOXA2

1.32e-052127228938408
Pubmed

Differential induction of HNF-3 transcription factors during neuronal differentiation.

FOXA1 FOXA2

1.32e-05212729260895
Pubmed

Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation.

FOXA1 FOXA2

1.32e-052127228235042
Pubmed

Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors.

FOXA1 FOXA2

1.32e-052127234789735
Pubmed

The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation.

RAPGEF6 RAPGEF2

1.32e-052127224858808
Pubmed

Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer.

FOXA1 FOXA2

1.32e-052127222265403
Pubmed

FOXA1/2 depletion drives global reprogramming of differentiation state and metabolism in a human liver cell line and inhibits differentiation of human stem cell-derived hepatic progenitor cells.

FOXA1 FOXA2

1.32e-052127236515690
Pubmed

Foxa1 and Foxa2 regulate bile duct development in mice.

FOXA1 FOXA2

1.32e-052127220347503
Pubmed

Foxa (HNF3) up-regulates vitronectin expression during retinoic acid-induced differentiation in mouse neuroblastoma Neuro2a cells.

FOXA1 FOXA2

1.32e-052127212441652
Pubmed

The pioneer transcription factors Foxa1 and Foxa2 regulate alternative RNA splicing during thymocyte positive selection.

FOXA1 FOXA2

1.32e-052127234323272
Pubmed

Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice.

FOXA1 FOXA2

1.32e-052127226283356
Pubmed

FBXW10 promotes hepatocarcinogenesis in male patients and mice.

FBXW10B FBXW10

1.32e-052127231400758
Pubmed

Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance.

FOXA1 FOXA2

1.32e-052127225249938
Pubmed

Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues.

FOXA1 FOXA2

1.32e-052127215567715
Pubmed

Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.

FBXW10B FBXW10

1.32e-052127237450367
Pubmed

The evolutionarily ancient FOXA transcription factors shape the murine gut microbiome via control of epithelial glycosylation.

FOXA1 FOXA2

1.32e-052127238821056
Pubmed

Foxa1 and Foxa2 control the differentiation of goblet and enteroendocrine L- and D-cells in mice.

FOXA1 FOXA2

1.32e-052127219737569
Pubmed

Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus.

FOXA1 FOXA2

1.32e-052127225211022
Pubmed

Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signal transduction.

FLT3 WNT3A

1.32e-052127215650056
Pubmed

Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer.

FOXA1 FOXA2

1.32e-052127220160041
Pubmed

Meta-Analysis of Transcriptome Data Related to Hippocampus Biopsies and iPSC-Derived Neuronal Cells from Alzheimer's Disease Patients Reveals an Association with FOXA1 and FOXA2 Gene Regulatory Networks.

FOXA1 FOXA2

1.32e-052127226890743
Pubmed

Negative regulation of hepatitis B virus replication by forkhead box protein A in human hepatoma cells.

FOXA1 FOXA2

1.32e-052127225836733
Pubmed

Nucleosome-binding affinity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA.

FOXA1 FOXA2

1.32e-052127219339686
Pubmed

Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking.

RAPGEF6 RAPGEF2

1.32e-052127232600317
Pubmed

Foxa1 and Foxa2 in thymic epithelial cells (TEC) regulate medullary TEC and regulatory T-cell maturation.

FOXA1 FOXA2

1.32e-052127230061015
Pubmed

Requirement for Shh and Fox family genes at different stages in sweat gland development.

FOXA1 FOXA2 FOXI1

1.32e-0513127319270025
Pubmed

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.

CHAF1A DHX15 SETD2 SUMO1

1.40e-0540127428805822
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MON2 NCKAP1 DOCK9 ADGRL1 FCHSD2 LRFN2 RHOBTB2 ULK2 ADGRL3

1.98e-05407127912693553
Pubmed

WW domains provide a platform for the assembly of multiprotein networks.

RAPGEF6 NCKAP1 SF3A1 DHX15 AP2A1 CPSF2

2.27e-05154127616055720
Pubmed

Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.

FOXA1 FOXA2 FOXI1

2.57e-0516127310208738
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

ERCC3 CHAF1A VPS16 INTS3 ATAD2 LIG3 PBRM1 AP2A1 TTC17 KIF2C

2.77e-055331271030554943
Pubmed

The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation.

FBXW10B FBXW10 ZMYM2 PKP1

3.43e-0550127426275350
Pubmed

FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth.

FOXA1 FOXA2

3.96e-053127227045898
Pubmed

A family of heptahelical receptors with adhesion-like domains: a marriage between two super families.

ADGRL1 ADGRL3

3.96e-053127210994649
Pubmed

PBRM1, SETD2 and BAP1 - the trinity of 3p in clear cell renal cell carcinoma.

SETD2 PBRM1

3.96e-053127236253570
Pubmed

The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.

FOXA1 FOXA2

3.96e-053127210899756
Pubmed

Expression and Mutation Patterns of PBRM1, BAP1 and SETD2 Mirror Specific Evolutionary Subtypes in Clear Cell Renal Cell Carcinoma.

SETD2 PBRM1

3.96e-053127230660076
Pubmed

FoxO1 and FoxA1/2 form a complex on DNA and cooperate to open chromatin at insulin-regulated genes.

FOXA1 FOXA2

3.96e-053127230142277
Pubmed

Protein or amino acid deprivation differentially regulates the hepatic forkhead box protein A (FOXA) genes through an activating transcription factor-4-independent pathway.

FOXA1 FOXA2

3.96e-053127219415718
Pubmed

A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits.

ITSN1 FCHSD2

3.96e-053127229887380
Pubmed

Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells.

FOXA1 FOXA2

3.96e-053127218336786
Pubmed

Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm.

FOXA1 FOXA2

3.96e-05312728187630
Pubmed

Exon-I is involved in positive as well as negative regulation of human angiotensinogen gene expression.

FOXA1 FOXA2

3.96e-05312729931457
Pubmed

Loss of Interdependent Binding by the FoxO1 and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin-sensitive Genes.

FOXA1 FOXA2

3.96e-053127226929406
Pubmed

The initiation of liver development is dependent on Foxa transcription factors.

FOXA1 FOXA2

3.96e-053127215959514
Pubmed

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.

PPP4R4 PPP2R1A

3.96e-05312729989501
Pubmed

The multiple actions of black widow spider toxins and their selective use in neurosecretion studies.

ADGRL1 ADGRL3

3.96e-053127215066411
Pubmed

Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain.

RAPGEF6 RAPGEF2

3.96e-053127229747665
Pubmed

FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity.

FOXA1 FOXA2

3.96e-053127233636105
Pubmed

Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.

FOXA1 FOXA2

3.96e-05312721672118
Pubmed

Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development.

MYO7A SULF2

3.96e-053127225370455
Pubmed

The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution.

FOXA1 FOXA2

3.96e-05312728034310
Pubmed

miR-491-5p, mediated by Foxi1, functions as a tumor suppressor by targeting Wnt3a/β-catenin signaling in the development of gastric cancer.

WNT3A FOXI1

3.96e-053127228358374
Pubmed

Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4.

FOXA1 FOXA2

3.96e-05312729119385
Pubmed

ZNF198, a zinc finger protein rearranged in myeloproliferative disease, localizes to the PML nuclear bodies and interacts with SUMO-1 and PML.

ZMYM2 SUMO1

3.96e-053127217027752
Pubmed

Foxa1 and Foxa2 regulate bile duct development in mice.

FOXA1 FOXA2

3.96e-053127219436110
Pubmed

Molecular mechanisms of liver development and differentiation.

FOXA1 FOXA2

3.96e-053127210600708
Pubmed

Genomic aberrations frequently alter chromatin regulatory genes in chordoma.

SETD2 PBRM1

3.96e-053127227072194
Pubmed

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.

FOXA1 FOXA2

3.96e-053127226551672
Pubmed

Forkhead box A1 (FOXA1) and A2 (FOXA2) oppositely regulate human type 1 iodothyronine deiodinase gene in liver.

FOXA1 FOXA2

3.96e-053127222067325
Pubmed

Chromatin remodeling mediated by the FOXA1/A2 transcription factors activates CFTR expression in intestinal epithelial cells.

FOXA1 FOXA2

3.96e-053127224440874
Pubmed

Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function.

FOXA1 FOXA2

3.96e-05312728248124
Pubmed

Computational analysis of the mutations in BAP1, PBRM1 and SETD2 genes reveals the impaired molecular processes in renal cell carcinoma.

SETD2 PBRM1

3.96e-053127226452128
Pubmed

alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.

ADGRL1 ADGRL3

3.96e-053127211520923
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

DOCK9 ITSN1 NAIP ADGRL1 GRIN2A AP2A1 SACS ADGRL3

4.33e-05347127817114649
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MON2 RAPGEF6 MYO7A PPP1R3B DOCK9 ADGRL1 SRCAP ITPR3 PCNX2 OVOL1 AP2A1 ANKRD34A FEM1A ULK2

5.44e-0511051271435748872
Pubmed

Distinct expression patterns of Sulf1 and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development.

HS6ST2 SULF2

7.90e-054127223074159
Pubmed

Overexpression of transcription factor FoxA2 in the developing skeleton causes an enlargement of the cartilage hypertrophic zone, but it does not trigger ectopic differentiation in immature chondrocytes.

FOXA1 FOXA2

7.90e-054127235398294
Pubmed

The expression of p21 is upregulated by forkhead box A1/2 in p53-null H1299 cells.

FOXA1 FOXA2

7.90e-054127225281925
Pubmed

Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding.

FOXA1 FOXA2

7.90e-054127212509444
Pubmed

Collapse of the hepatic gene regulatory network in the absence of FoxA factors.

FOXA1 FOXA2

7.90e-054127232561546
Pubmed

Cytogenetically cryptic ZMYM2-FLT3 and DIAPH1-PDGFRB gene fusions in myeloid neoplasms with eosinophilia.

FLT3 ZMYM2

7.90e-054127228751768
Pubmed

Hepatocyte-specific HDAC3 ablation promotes hepatocellular carcinoma in females by suppressing Foxa1/2.

FOXA1 FOXA2

7.90e-054127237752418
Pubmed

ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer.

FOXA1 FOXA2

7.90e-054127220048076
Pubmed

Integrative genomic analysis identifies that SERPINA6-rs1998056 regulated by FOXA/ERα is associated with female hepatocellular carcinoma.

FOXA1 FOXA2

7.90e-054127225198130
Pubmed

Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice.

GRIN2A LRFN2

7.90e-054127228604739
Pubmed

Aberrant promoter hypermethylation of PBRM1, BAP1, SETD2, KDM6A and other chromatin-modifying genes is absent or rare in clear cell RCC.

SETD2 PBRM1

7.90e-054127223644518
Pubmed

The p150 subunit of CAF-1 causes association of SUMO2/3 with the DNA replication foci.

CHAF1A SUMO1

7.90e-054127219919826
Pubmed

The ratio of FoxA1 to FoxA2 in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor LSH.

FOXA1 FOXA2

7.90e-054127226658322
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

NCKAP1 GRIN2A PPP2R1A AP2A1 SACS PKP1 RAPGEF2

8.16e-05281127728706196
Pubmed

Embryonic Steroids Control Developmental Programming of Energy Balance.

PPP1R3B FOXA1 FOXA2

1.30e-0427127334599818
Pubmed

FBXW10-S6K1 promotes ANXA2 polyubiquitination and KRAS activation to drive hepatocellular carcinoma development in males.

FBXW10B FBXW10

1.31e-045127237277019
Pubmed

Characterization of the SUMO-binding activity of the myeloproliferative and mental retardation (MYM)-type zinc fingers in ZNF261 and ZNF198.

ZMYM2 SUMO1

1.31e-045127225133527
Pubmed

Foxa1 and Foxa2 orchestrate development of the urethral tube and division of the embryonic cloaca through an autoregulatory loop with Shh.

FOXA1 FOXA2

1.31e-045127232645357
Pubmed

FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer.

FOXA1 FOXA2

1.31e-045127230475207
Pubmed

Chronological expression of Ciliated Bronchial Epithelium 1 during pulmonary development.

FOXA1 FOXA2

1.31e-045127219213785
Pubmed

Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues.

FOXA1 FOXA2

1.31e-04512729032290
Pubmed

Radiogenomics of clear cell renal cell carcinoma: associations between CT imaging features and mutations.

SETD2 PBRM1

1.31e-045127224029645
Pubmed

A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism.

FOXA1 FOXA2

1.31e-045127215737987
Pubmed

Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration.

DUSP8 WNT3A

1.31e-045127234197726
CytobandEnsembl 112 genes in cytogenetic band chrXq26

CT45A6 CT45A1 HS6ST2 CT45A10 CT45A2 CT45A7 CT45A9 CT45A8 CT45A3 CT45A5

6.62e-1117112910chrXq26
CytobandEnsembl 112 genes in cytogenetic band chr7q11

SPDYE17 SPDYE10 SPDYE9 SPDYE12 SPDYE11 SPDYE13 SPDYE15 SPDYE8 SPDYE14

8.42e-082711299chr7q11
CytobandXq26.3

CT45A6 CT45A1 CT45A2 CT45A3 CT45A5

1.36e-06671295Xq26.3
Cytoband7q11.23

SPDYE10 SPDYE9 SPDYE8 SPDYE14

1.68e-049712947q11.23
GeneFamilyA-kinase anchoring proteins|Myosins, class VII|Deafness associated genes|FERM domain containing

MYO7A MYO7B

2.13e-0528421102
GeneFamilyAdhesion G protein-coupled receptors, subfamily L

ADGRL1 ADGRL3

1.27e-044842918
GeneFamilyForkhead boxes

FOXA1 FOXA2 FOXI1

1.04e-0343843508
GeneFamilyWD repeat domain containing|F-box and WD repeat domain containing

FBXW10B FBXW10

1.14e-0311842559
GeneFamilySpeedy/RINGO cell cycle regulator family

SPDYE9 SPDYE8

1.37e-0312842756
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_MYOFIBROBLAST_1_CELL

CT45A6 CT45A1 CT45A10 CT45A2 CT45A7 CT45A9 CT45A8 CT45A3 CT45A5

3.16e-11691219M45681
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_MYOFIBROBLAST_2_CELL

CT45A6 CT45A1 CT45A10 CT45A2 CT45A7 CT45A9 CT45A8 CT45A3 CT45A5

1.34e-091041219M45682
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

CAMK1D DOCK8 SF3A1 ATAD2 SETD2 FCHSD2 RHOBTB2

2.09e-051801217M8239
CoexpressionGSE17974_0.5H_VS_72H_IL4_AND_ANTI_IL12_ACT_CD4_TCELL_UP

RAPGEF6 SF3A1 SAMD4B ETV3 SETD2 RAPGEF2 FEM1A

3.61e-051961217M4244
CoexpressionGSE11864_UNTREATED_VS_CSF1_PAM3CYS_IN_MAC_UP

IL12A FLT3 SAMD4B SETD2 SULF2 OXCT1 AP2A1

3.85e-051981217M3129
CoexpressionGSE40068_BCL6_POS_VS_NEG_CXCR5_POS_TFH_DN

NR2C1 RAPGEF6 ZMYM2 ADGRL1 RPS29 SULF2 RAPGEF2

4.11e-052001217M9260
CoexpressionZHAN_MULTIPLE_MYELOMA_MF_DN

CAMK1D DOCK9 ITSN1 RAPGEF2

4.64e-05431214M513
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CT45A6 CT45A1 ASIC2 CT45A10 CT45A2 CT45A9 CT45A5

2.79e-071571237b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CT45A6 CT45A1 CT45A10 CT45A2 CT45A9 CT45A5

7.85e-061701236fefb07a7e308b620f946b9ff2b01e1796446fe38
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_6|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FLT3 FBXL13 CHAF1A SULF2 OXCT1 ANKRD34A

9.89e-0617712363a150dcaefa342d49968b42c7cdb1fbb633adcd0
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_6|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

FLT3 FBXL13 CHAF1A SULF2 OXCT1 ANKRD34A

9.89e-061771236c9e5820ff0bc7ad1adcfb2651713fdfc58bced56
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CT45A6 CT45A1 CT45A10 CT45A2 CT45A9 CT45A5

1.48e-051901236d24af6af3271e34afab744352afd28be8a7cc5c3
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_1|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CT45A6 CT45A1 CT45A10 CT45A2 CT45A9 CT45A5

1.48e-05190123671a00f63fdd4eb4cc6f190d37e7a0417cdaafacb
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CT45A6 CT45A1 CT45A10 CT45A2 CT45A9 CT45A5

1.62e-0519312362f203f6f0c2135acb046c9351a633c3b5b254a46
ToppCellAdult-Immune-monocyte|Adult / Lineage, Cell type, age group and donor

FLT3 CAMK1D DOCK8 NAIP SULF2 PLCB2

1.76e-0519612363ef193c5180de3137daf886492e74fc574bc9767
ToppCellChildren_(3_yrs)-Immune-monocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

FLT3 CAMK1D DOCK8 NAIP SULF2 PLCB2

1.76e-051961236cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCellParenchymal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FLT3 PPP1R3B CHAF1A ETV3 FCHSD2 SULF2

1.76e-051961236b10b386aacc672949560df2dbb0d4f76cf62e213
ToppCellLPS_only-Hematopoietic_Myeloid-Dendritic_cells-mDC|LPS_only / Treatment groups by lineage, cell group, cell type

FLT3 CAMK1D DOCK8 ETV3 SULF2 PLCB2

1.87e-05198123653c22e81e530d6fc272d4a45c8d1bf125feb254d
ToppCellImmune-monocyte|World / Lineage, Cell type, age group and donor

FLT3 CAMK1D DOCK8 NAIP SULF2 PLCB2

1.87e-051981236d3622da252fd580f1dc5c7478a8e23df5ec083cf
DrugMethantheline bromide [53-46-3]; Up 200; 9.6uM; MCF7; HT_HG-U133A

MON2 ADGRL1 SRCAP FOXA2 PPP4R4 LIG3 SV2C KEL MUC5AC

7.86e-0719911593560_UP
Diseasecolorectal cancer (is_marker_for)

ERCC3 FOXA1 SETD2 PBRM1 PIK3CB KIF2C

2.39e-051571076DOID:9256 (is_marker_for)
Diseaseage at initiation of smoking

CAMK1D ASIC2 GRIN2A ITPR3

9.91e-05661074EFO_0021784
DiseaseIntellectual Disability

DOCK8 RRM2B ZMYM2 SHROOM4 PPP2R1A SETD2 SACS RHOBTB2

2.30e-044471078C3714756
DiseaseNeurodevelopmental Disorders

NCKAP1 DOCK8 SRCAP SETD2

3.72e-04931074C1535926
DiseaseNeoplasm of uncertain or unknown behavior of breast

FOXA1 PBRM1 PIK3CB

4.47e-04411073C0496956
DiseaseBreast adenocarcinoma

FOXA1 PBRM1 PIK3CB

4.47e-04411073C0858252
Diseasecortical thickness

MON2 FBXW10 FBXL13 ASIC2 PPP1R3B DOCK9 CHAF1A ZIC4 SULF2 WNT3A FSHR ULK2

7.18e-04111310712EFO_0004840
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

NCKAP1 GRIN2A SRCAP

7.57e-04491073DOID:0060037 (implicated_via_orthology)
Diseasepneumonia, COVID-19

COPG1 ASIC2 IFI44 LRP1B

7.77e-041131074EFO_0003106, MONDO_0100096
Diseaseblood copper measurement

CAMK1D OR7C1 ITPR3

8.03e-04501073EFO_0007578
Diseasemood disorder

PBRM1 SV2C

9.90e-04131072EFO_0004247
Diseasefibrinogen measurement, coronary artery disease

RAPGEF6 EDNRA SUMO1 TTC17

2.43e-031541074EFO_0001645, EFO_0004623

Protein segments in the cluster

PeptideGeneStartEntry
CLMSKFTAQRLRPFY

NAIP

726

Q13075
LRQYFRNLCSDDTPM

PPP2R1A

166

P30153
QRIMPVRNFSKFSDC

CEP19

31

Q96LK0
LMRCFEDKRNNPFQF

CPSF2

291

Q9P2I0
SRFMRVPINDNYCEK

DUSP8

206

Q13202
VQCYLPDAFKIMSQR

ADGRL1

81

O94910
CKPQMNYDKLSRALR

ETV3

81

P41162
MENLESRLKNAPYFR

FBXW10

1

Q5XX13
PDAYKIMSQRCNNRT

ADGRL3

81

Q9HAR2
CLLRLEPNAQAQMYR

AP2A1

941

O95782
LRDCAIQYFMQKFQL

CMTR2

396

Q8IYT2
ECDSPSYQKRQRMAL

CT45A5

21

P0DMU8
YQNKCMRNGPNALIA

EDNRA

106

P25101
LPNRFDMNVCSRFVK

ANKRA2

56

Q9H9E1
NRNACYQPMSFRPRI

ATAD2

781

Q6PL18
NPYFSNLRQNMKDLI

CDADC1

266

Q9BWV3
NPIIYCFMNKRFRLG

CCKAR

366

P32238
RMKLLQFCENHRPAY

CHAF1A

556

Q13111
YDMSNFPQCEAKRQL

DHX15

766

O43143
ECDSPSYQKRQRMAL

CT45A7

21

P0DMV0
CRARYDDPQNKARMV

ANKRD34A

46

Q69YU3
LLKMDNAYKFPNLRC

AOX1

891

Q06278
RTPCNLTRYNKELSM

ASIC2

361

Q16515
QPNSKYKTSMCRDLR

RC3H2

406

Q9HBD1
QYCRLQRCIAFGMKQ

NR2C1

166

P13056
KPLYLIFRNLCQMQE

INTS3

651

Q68E01
LFKVCPMNRYSAQKQ

ITPR3

56

Q14573
DKSFQNIMRCYRTQP

RBL2

906

Q08999
MENLESRLKNAPYFR

FBXW10B

1

O95170
ITKNRLYRENDCMFP

POGLUT1

91

Q8NBL1
NVMPSKQRRQCSTYL

MGAT4C

416

Q9UBM8
NPFIYSLRNRDMKEA

OR1J2

286

Q8NGS2
DLNLMFENAKRYNVP

PBRM1

451

Q86U86
RYINFKMANLSRCNL

KCTD9

236

Q7L273
IYDPRKQQGDNMCRV

LRP1B

786

Q9NZR2
MIYCNSNFQRDKPRL

HSFX4

161

A0A1B0GTS1
CRKPIYLMNNFNARF

KRT39

66

Q6A163
PMIKDFRRYLQSNTA

NAIF1

291

Q69YI7
ECDSPSYQKRQRMAL

CT45A10

21

P0DMU9
YRPRKCRQMSYAQDL

GALNT9

136

Q9HCQ5
FLYMQKTLRQCQEQR

IL19

111

Q9UHD0
QCKAIFYMNNPSRVL

FETUB

116

Q9UGM5
KMLQRREALFCIQYN

MYH8

806

P13535
MKLLRTSFCNPVYQF

PCNX2

1231

A6NKB5
FPRMFKCSRRRYQQG

P3R3URF

31

A0A087WWA1
ECDSPSYQKRQRMAL

CT45A3

21

Q8NHU0
DQQGPFKMCLNYEVR

MUC5AC

2196

P98088
MLQKARQTLEFYPCT

IL12A

51

P29459
PQLLRSFCQSYDMKQ

MON2

366

Q7Z3U7
FRKLCAMVADNPSYN

LIG3

266

P49916
MIYCNSNFQRDKPRL

HSFX3

161

A0A1B0GWH4
CAMPALYRNQNYNKL

GPR75

266

O95800
KMFQQCLELPSQSRY

NCKAP1

551

Q9Y2A7
RVCQKAFTYQRMLNR

OVOL1

121

O14753
FSYMRPRSQCTLLQN

OR2AE1

256

Q8NHA4
VPNFLKDMARACQNY

PCTP

196

Q9UKL6
GNMFENGCYLRRQKR

FOXA1

251

P55317
NPFIYSLRNTDMKRA

OR7C1

286

O76099
PYFRKMENQDALVCI

FLT3

171

P36888
ECDSPSYQKRQRMAL

CT45A1

21

Q5HYN5
ECDSPSYQKRQRMAL

CT45A9

21

P0DMV2
RDRYQFNPMESIKLN

IFI44

276

Q8TCB0
QAESFCQRLGKYRMP

DOCK8

386

Q8NF50
AKQACQRLGQYRMPF

DOCK9

511

Q9BZ29
ECDSPSYQKRQRMAL

CT45A2

21

Q5DJT8
MQPYIRFCSRQLNGA

ITSN1

1326

Q15811
MQPFNYVTLQCLAAR

FEM1A

631

Q9BSK4
MNRAVTCYNFRLQKS

FBXL13

41

Q8NEE6
ECDSPSYQKRQRMAL

CT45A8

21

P0DMV1
KEFMDCPYNLANNRQ

HS6ST2

376

Q96MM7
LFQSNDPTLRRMCYL

COPG1

76

Q9Y678
ILLYTMNPNKFRACQ

ERCC3

531

P19447
PNCEKMFDNGNFRRK

FOXI1

201

Q12951
RMNICENYKNFISEP

FCHSD2

101

O94868
QYKLTVPRFLMCNLA

FSHR

391

P23945
KLDNCTMFRFPLRNA

SACS

2691

Q9NZJ4
MASRDVFLLKNQPCY

KIF2C

376

Q99661
ECDSPSYQKRQRMAL

CT45A6

21

P0DMU7
NCMAPSLRQERFAFK

PPP1R3B

11

Q86XI6
TLNPFIYSLRNRDMK

OR1N2

301

Q8NGR9
IFMYLQPANRRSKNQ

OR2G6

256

Q5TZ20
NMFENGCYLRRQKRF

FOXA2

241

Q9Y261
RNLMASQPQLAKQYF

PKP1

666

Q13835
APLARLNLRNNKFMY

SLITRK4

496

Q8IW52
IFDPSRNMAKYRNIL

RAPGEF6

986

Q8TEU7
IRKYGLNMCRQCFRQ

RPS29

31

P62273
LNMCRQCFRQYAKDI

RPS29

36

P62273
FMRCFNYPVRDNTIK

SV2C

421

Q496J9
ISVRKNCAYNFPAMI

PPP4R4

371

Q6NUP7
MMYTRNNLNCAEPLF

LIPI

46

Q6XZB0
LKCPYQMFREFQLLT

SAMD3

336

Q8N6K7
CTNYNNVCRKFPRDM

RHOBTB2

636

Q9BYZ6
RYMNPRARKNCSQIA

SPDYE10

206

P0DUX0
RYMNPRARKNCSQIA

SPDYE11

206

P0DTA3
RYMNPRARKNCSQIA

SPDYE8

206

P0DUD1
ALLKRNMMPNCYNCR

SHROOM4

911

Q9ULL8
YCQRQGVPMNSLRFL

SUMO1

51

P63165
VIFRKSARNFNLPMC

OXCT1

221

P55809
FQYIRNCVMNRALPH

PIK3CB

266

P42338
CNMRTQFPDLRLIQY

SRCAP

2026

Q6ZRS2
MQKEQRNYQFDFLRP

SF3A1

186

Q15459
IRNLMEKDPNKRYTC

CAMK1D

256

Q8IU85
CLMFQYLVNKPSEER

RRM2B

236

Q7LG56
QDLFDPSRNMAKYRN

RAPGEF2

841

Q9Y4G8
MPEQLFKYQEDCQAR

UBN2

551

Q6ZU65
LRTFPRKAALEMQNY

SAMD4B

531

Q5PRF9
NRMYGCDSVKQPRNI

GTF2A1L

301

Q9UNN4
RYMNPRARKNCSQIA

SPDYE12

206

P0DUX1
RYMNPRARKNCSQIA

SPDYE13

206

A0A494C0Z2
RYMNPRARKNCSQIA

SPDYE14

206

P0DUD3
RYMNPRARKNCSQIA

SPDYE15

206

P0DUD4
RYMNPRARKNCSQIA

SPDYE17

206

P0DUD2
NQPMALSLYRQFCKH

VPS16

596

Q9H269
KCEHPRAYFMQLQTR

POLR3K

71

Q9Y2Y1
ENSLKLIRCMQFYPF

TTC17

726

Q96AE7
VDSPRQQAKMAEYCR

PLCB2

411

Q00722
KEMSQFIVQCLNPYR

SETD2

2476

Q9BYW2
FCKRNSLPQYQATMP

ZMYM2

586

Q9UBW7
FFRYMRQPIKQELIC

ZIC4

116

Q8N9L1
ANSPQDLRMFYEKNR

ULK2

216

Q8IYT8
LRMYANKQERLPNFL

ZCCHC18

196

P0CG32
KQLRFCRNYVEIMPS

WNT3A

51

P56704
RYMNPRARKNCSQIA

SPDYE9

206

A0A494C191
LYRQAISMRPDFKQA

TMTC3

551

Q6ZXV5
CKGYKQCNPRTRNMD

SULF2

816

Q8IWU5
QIFFRSYAQVMCRKP

KEL

671

P23276
APRVKMYQLQYNCSD

LRFN2

446

Q9ULH4
AIADNCYFNMKRNSR

MYO7A

136

Q13402
AIANNCYFSMKRNKR

MYO7B

136

Q6PIF6
NSCSNRRVYKKMPSI

GRIN2A

1446

Q12879