Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium ion binding

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.11e-04749145GO:0005509
GeneOntologyMolecularFunctionextracellular matrix structural constituent conferring tensile strength

COL4A3 COL16A1

4.64e-0446142GO:0030020
GeneOntologyBiologicalProcesshomophilic cell adhesion via plasma membrane adhesion molecules

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.09e-07187145GO:0007156
GeneOntologyBiologicalProcesscell-cell adhesion via plasma-membrane adhesion molecules

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.39e-06313145GO:0098742
GeneOntologyBiologicalProcesscell-cell adhesion

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4 LPP CTNND1

2.58e-061077147GO:0098609
GeneOntologyCellularComponentcollagen trimer

COL4A3 COL16A1

1.54e-0388142GO:0005581
DomainCadherin_CBD

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

4.55e-1137145IPR031904
DomainCadherin_tail

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

4.55e-1137145PF15974
DomainCadherin_N

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

8.53e-1065145IPR013164
DomainCadherin_2

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

8.53e-1065145PF08266
DomainCadherin_CS

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.18e-08109145IPR020894
DomainCadherin

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.42e-08113145PF00028
DomainCADHERIN_1

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.42e-08113145PS00232
Domain-

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.49e-081141452.60.40.60
DomainCADHERIN_2

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.49e-08114145PS50268
DomainCA

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.55e-08115145SM00112
DomainCadherin-like

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.62e-08116145IPR015919
DomainCadherin

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.77e-08118145IPR002126
DomainCadherin_C_2

PCDHAC2 PCDHA7

4.42e-0442142PF16492
DomainCadherin_C

PCDHAC2 PCDHA7

4.42e-0442142IPR032455
DomainCollagen

COL4A3 COL16A1

1.80e-0385142IPR008160
DomainCollagen

COL4A3 COL16A1

1.80e-0385142PF01391
PathwayREACTOME_COLLAGEN_CHAIN_TRIMERIZATION

COL4A3 COL16A1

2.29e-044182MM15538
PathwayPID_ECADHERIN_STABILIZATION_PATHWAY

LPP CTNND1

2.29e-044182M232
PathwayREACTOME_COLLAGEN_CHAIN_TRIMERIZATION

COL4A3 COL16A1

2.63e-044482M27812
PathwayPID_SYNDECAN_1_PATHWAY

COL4A3 COL16A1

2.88e-044682M198
PathwayREACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES

COL4A3 COL16A1

5.07e-046182MM14637
PathwayREACTOME_COLLAGEN_DEGRADATION

COL4A3 COL16A1

5.58e-046482M26953
PathwayREACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES

COL4A3 COL16A1

6.12e-046782M26999
PathwayPID_AVB3_INTEGRIN_PATHWAY

COL4A3 COL16A1

7.46e-047482M160
PathwayREACTOME_COLLAGEN_FORMATION

COL4A3 COL16A1

7.86e-047682MM14573
PathwayREACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

COL4A3 COL16A1

7.86e-047682MM14867
PathwayREACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

COL4A3 COL16A1

9.83e-048582M16441
PathwayREACTOME_COLLAGEN_FORMATION

COL4A3 COL16A1

1.10e-039082M631
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

COL4A3 COL16A1

2.64e-0314082M587
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

COL4A3 COL16A1

8.69e-0325882MM14572
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

COL4A3 COL16A1

1.16e-0230082M610
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

COL4A3 CTNND1

2.18e-0241882MM15587
Pubmed

Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.42e-141514515640798
Pubmed

Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

2.91e-141714529911975
Pubmed

Genomic organization of the family of CNR cadherin genes in mice and humans.

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

4.04e-141814510662547
Pubmed

CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

4.04e-141814515570159
Pubmed

Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

2.00e-132414524698270
Pubmed

Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.

PCDHA12 PCDHA7 PCDHA5 PCDHA4

5.41e-12111449655502
Pubmed

Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.96e-115714532633719
Pubmed

CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

2.14e-115814530377227
Pubmed

Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

4.86e-116814511230163
Pubmed

A striking organization of a large family of human neural cadherin-like cell adhesion genes.

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

6.51e-117214510380929
Pubmed

Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

7.50e-117414510817752
Pubmed

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4 LPP

7.82e-1119314622589738
Pubmed

Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

9.19e-117714510835267
Pubmed

Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.12e-108014510716726
Pubmed

Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.

PCDHA12 PCDHA7 PCDHA5 PCDHA4

3.34e-102814415347688
Pubmed

A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

8.42e-1011914528625976
Pubmed

Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model.

PCDHAC2 PCDHA5 PCDHA4

4.36e-09914312154121
Pubmed

Proteins of the CNR family are multiple receptors for Reelin.

PCDHA7 PCDHA5 PCDHA4

1.14e-081214310612399
Pubmed

The DNA sequence and comparative analysis of human chromosome 5.

PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.96e-087514415372022
Pubmed

Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease.

PCDHA12 PCDHA7

1.50e-06514234888534
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

DCP1B LPP CTNND1

7.42e-0520914336779422
Pubmed

α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.

LPP CTNND1

8.89e-053514237381005
Pubmed

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

DCP1B LPP CTNND1

2.78e-0432714315592455
Pubmed

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

COL4A3 COL16A1

2.81e-046214228344315
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

PCDHA12 PCDHA7 PCDHA5

2.83e-0432914317474147
InteractionPCDHA10 interactions

PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.06e-0922144int:PCDHA10
InteractionPCDHA8 interactions

PCDHAC2 PCDHA12 PCDHA7 PCDHA4

4.87e-0855144int:PCDHA8
InteractionPCDHA7 interactions

PCDHA12 PCDHA7 PCDHA4

9.67e-0814143int:PCDHA7
InteractionPCDHA11 interactions

PCDHAC2 PCDHA12 PCDHA4

2.57e-0719143int:PCDHA11
InteractionPCDHA9 interactions

PCDHAC2 PCDHA7 PCDHA4

1.31e-0632143int:PCDHA9
InteractionFLT3 interactions

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.69e-06318145int:FLT3
InteractionPCDHA12 interactions

PCDHA12 PCDHA7 PCDHA4

3.98e-0646143int:PCDHA12
InteractionPCDHA4 interactions

PCDHA12 PCDHA7 PCDHA4

8.92e-0660143int:PCDHA4
InteractionFRMD5 interactions

PCDHAC2 PCDHA12 CTNND1

1.30e-0568143int:FRMD5
InteractionPCDHGA10 interactions

PCDHA12 PCDHA4

7.61e-0519142int:PCDHGA10
InteractionCOL17A1 interactions

WHRN CTNND1

2.48e-0434142int:COL17A1
InteractionMAP3K6 interactions

PCDHA12 PCDHA4

5.60e-0451142int:MAP3K6
InteractionCNNM1 interactions

PCDHA12 PCDHA4

6.75e-0456142int:CNNM1
InteractionTMEM223 interactions

PCDHAC2 PCDHA4

7.24e-0458142int:TMEM223
InteractionLONP2 interactions

PCDHA12 PCDHA4

8.27e-0462142int:LONP2
Cytoband5q31

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.78e-101151455q31
CytobandEnsembl 112 genes in cytogenetic band chr5q31

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

2.13e-08298145chr5q31
GeneFamilyClustered protocadherins

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

5.97e-106413520
GeneFamilyCollagens

COL4A3 COL16A1

4.85e-0446132490
CoexpressionLEE_METASTASIS_AND_ALTERNATIVE_SPLICING_DN

PCDHAC2 PCDHA12 PCDHA5

1.70e-0645143M13714
CoexpressionMIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED

PCDHA12 PCDHA7 PCDHA5 PCDHA4

6.18e-06238144M2020
CoexpressionMIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED

PCDHA12 PCDHA7 PCDHA5 PCDHA4

8.89e-06261144MM1277
CoexpressionNABA_COLLAGENS

COL4A3 COL16A1

2.36e-0443142MM17060
CoexpressionNABA_COLLAGENS

COL4A3 COL16A1

2.47e-0444142M3005
DrugAzacitidine

PCDHA12 PCDHA7 PCDHA5 PCDHA4

9.42e-05415144ctd:D001374
DrugZardaverine [101975-10-4]; Up 200; 15uM; HL60; HT_HG-U133A

PCDHA5 LPP CTNND1

1.55e-041761432926_UP
DrugAcetaminophen [103-90-2]; Up 200; 26.4uM; PC3; HT_HG-U133A

WHRN PCDHA5 COL16A1

2.16e-041971436284_UP
DrugGentamicine sulfate [1405-41-0]; Up 200; 2.6uM; PC3; HT_HG-U133A

COL4A3 PCDHA5 COL16A1

2.16e-041971435883_UP
DrugChlorphensin carbamate [886-74-8]; Up 200; 16.2uM; MCF7; HT_HG-U133A

COL4A3 WHRN COL16A1

2.16e-041971432279_UP
DrugGK-101

COL4A3 COL16A1

2.19e-0436142CID000161853
DrugMyosmine [532-12-7]; Up 200; 27.4uM; PC3; HT_HG-U133A

COL4A3 LPP COL16A1

2.20e-041981434293_UP
DrugFenspiride hydrochloride [5053-08-7]; Up 200; 13.4uM; MCF7; HT_HG-U133A

COL4A3 PCDHA5 COL16A1

2.20e-041981432269_UP
DrugPinacidil [85371-64-8]; Up 200; 16.4uM; HL60; HT_HG-U133A

COL4A3 PCDHA5 CTNND1

2.23e-041991432406_UP
DrugCyclacillin [3485-14-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A

COL4A3 WHRN COL16A1

2.23e-041991433882_UP
DrugRitodrine hydrochloride [23239-51-2]; Up 200; 12.4uM; MCF7; HT_HG-U133A

COL4A3 WHRN COL16A1

2.23e-041991432635_UP
DrugEthynylestradiol 3-methyl ether [72-33-3]; Down 200; 12.8uM; HL60; HT_HG-U133A

COL4A3 LPP CTNND1

2.26e-042001433008_DN
Diseasevisceral adipose tissue measurement, body mass index

PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4

3.89e-1087145EFO_0004340, EFO_0004765
Disease1,5 anhydroglucitol measurement

PCDHA12 PCDHA7 PCDHA5 PCDHA4

7.48e-1029144EFO_0008009
Diseaseneutrophil count, basophil count

PCDHA12 PCDHA7 PCDHA5 PCDHA4

3.05e-06224144EFO_0004833, EFO_0005090
Diseasepost-traumatic stress disorder symptom measurement

PCDHA7 PCDHA5 PCDHA4

7.36e-0682143EFO_0008535
DiseaseAbnormality of refraction

COL4A3 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.03e-05673145HP_0000539
Diseasepulse pressure measurement

PCDHA12 PCDHA7 PCDHA5 PCDHA4 LPP CTNND1

2.36e-051392146EFO_0005763
Diseasepost-traumatic stress disorder

PCDHA7 PCDHA5 PCDHA4

1.09e-04202143EFO_0001358
Diseaseneuroticism measurement, cognitive function measurement

PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.15e-04566144EFO_0007660, EFO_0008354
Diseasevital capacity

ZNF341 PCDHA12 PCDHA7 PCDHA5 PCDHA4

1.87e-041236145EFO_0004312
Diseaseoverall survival, pancreatic carcinoma

DCP1B WHRN

2.43e-0449142EFO_0000638, EFO_0002618
Diseaseintraocular pressure measurement

COL4A3 LPP COL16A1

1.61e-03509143EFO_0004695
DiseaseHereditary hearing loss and deafness

COL4A3 WHRN

2.13e-03146142cv:C0236038
DiseaseLeukemia, Myelocytic, Acute

BCOR LPP

2.97e-03173142C0023467
Diseaseneutrophil count

PCDHA12 PCDHA7 PCDHA5 PCDHA4

3.29e-031382144EFO_0004833
DiseaseDisorder of eye

BCOR WHRN

4.42e-03212142C0015397
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

WHRN ZNF341

5.58e-03239142EFO_0010934

Protein segments in the cluster

PeptideGeneStartEntry
FQGFPGVKGEKGNPG

COL4A3

1311

Q01955
GFQNFVGLPGKPGPK

COL16A1

516

Q07092
GKYPKAPEGGEGAQP

BCOR

391

Q6W2J9
FKYGPGNPKQSGPGE

PCDHA7

856

Q9UN72
PKPKYNPYKQPGGEG

LPP

51

Q93052
KYGPGNPKQSGPGEL

PCDHA5

856

Q9Y5H7
FKYGPGNPKQSGPGE

PCDHAC2

926

Q9Y5I4
FKYGPGNPKQSGPGE

PCDHA4

866

Q9UN74
PGKGLAQPPQAYFNG

DCP1B

396

Q8IZD4
DFRKNGNGGPGPYVG

CTNND1

181

O60716
KYGPGNPKQSGPGEL

PCDHA12

861

Q9UN75
DFYPNGGNKQPGCPK

LIPI

226

Q6XZB0
TEGINKPGFYKGPAG

WHRN

396

Q9P202
PTVYSPGKQGFKPKG

ZNF341

261

Q9BYN7
QPEGKGQETYPGPGK

TXNRD3NB

96

Q6F5E7