Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	metalloaminopeptidase activity	LVRN ERAP1 LNPEP RNPEPL1	5.41e-07	26	51	4	GO:0070006
GeneOntologyMolecularFunction	aminopeptidase activity	LVRN ERAP1 LNPEP RNPEPL1	4.33e-06	43	51	4	GO:0004177
GeneOntologyMolecularFunction	metalloexopeptidase activity	LVRN ERAP1 LNPEP RNPEPL1	3.06e-05	70	51	4	GO:0008235
GeneOntologyMolecularFunction	exopeptidase activity	LVRN ERAP1 LNPEP RNPEPL1	1.78e-04	110	51	4	GO:0008238
GeneOntologyBiologicalProcess	peptide catabolic process	LVRN ERAP1 LNPEP	2.29e-05	23	50	3	GO:0043171
Domain	Peptidase_M1	LVRN ERAP1 LNPEP RNPEPL1	2.21e-08	12	50	4	IPR001930
Domain	Peptidase_M1	LVRN ERAP1 LNPEP RNPEPL1	3.19e-08	13	50	4	PF01433
Domain	Peptidase_M1_N	LVRN ERAP1 LNPEP RNPEPL1	3.19e-08	13	50	4	IPR014782
Domain	ERAP1-like_C_dom	LVRN ERAP1 LNPEP	1.00e-06	8	50	3	IPR024571
Domain	ERAP1_C	LVRN ERAP1 LNPEP	1.00e-06	8	50	3	PF11838
Domain	ZINC_PROTEASE	LVRN ERAP1 LNPEP RNPEPL1	1.36e-04	98	50	4	PS00142
Domain	Ptc/Disp	PTCHD3 DISP3	2.50e-04	9	50	2	IPR003392
Domain	Patched	PTCHD3 DISP3	2.50e-04	9	50	2	PF02460
Domain	ARM-type_fold	USP34 GPRASP1 RNPEPL1 SCYL3 IPO4 TRIP12	2.77e-04	339	50	6	IPR016024
Domain	SSD	PTCHD3 DISP3	5.38e-04	13	50	2	IPR000731
Domain	SSD	PTCHD3 DISP3	5.38e-04	13	50	2	PS50156
Domain	HEAT_type_2	SCYL3 IPO4	9.31e-04	17	50	2	IPR021133
Domain	-	RBP3 ECI2	1.43e-03	21	50	2	3.90.226.10
Domain	ClpP/crotonase-like_dom	RBP3 ECI2	1.43e-03	21	50	2	IPR029045
Domain	G_patch	ZGPAT CMTR1	1.71e-03	23	50	2	SM00443
Domain	G_patch_dom	ZGPAT CMTR1	1.71e-03	23	50	2	IPR000467
Domain	G_PATCH	ZGPAT CMTR1	1.71e-03	23	50	2	PS50174
Domain	G-patch	ZGPAT CMTR1	1.71e-03	23	50	2	PF01585
Domain	-	GPRASP1 SCYL3 IPO4 TRIP12	2.92e-03	222	50	4	1.25.10.10
Domain	ARM-like	GPRASP1 SCYL3 IPO4 TRIP12	5.84e-03	270	50	4	IPR011989
Domain	HEAT	SCYL3 IPO4	7.32e-03	48	50	2	PF02985
Domain	Quinoprotein_ADH-like_supfam	WDR1 EML3	8.87e-03	53	50	2	IPR011047
Pubmed	Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.	CFAP47 USP34 HENMT1 PTTG3P EXOSC10 MTMR14 TRIP12	4.85e-07	326	51	7	17015433
Pubmed	Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1.	ERAP1 LNPEP	2.11e-06	2	51	2	20592285
Pubmed	The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.	LVRN ERAP1 LNPEP	3.88e-06	21	51	3	19578876
Pubmed	Identification of 33 polymorphisms in the adipocyte-derived leucine aminopeptidase (ALAP) gene and possible association with hypertension.	ERAP1 LNPEP	6.32e-06	3	51	2	11857741
Pubmed	Regulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-gamma.	ERAP1 LNPEP	6.32e-06	3	51	2	15691326
Pubmed	Cell-Specific and Variant-Linked Alterations in Expression of ERAP1, ERAP2, and LNPEP Aminopeptidases in Psoriasis.	ERAP1 LNPEP	6.32e-06	3	51	2	36716917
Pubmed	Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.	ERAP1 LNPEP	6.32e-06	3	51	2	21314638
Pubmed	The oxytocinase subfamily of M1 aminopeptidases.	ERAP1 LNPEP	6.32e-06	3	51	2	16054015
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	USP34 EPS15 DISP3 PYGB IPO4 TRIP12	7.62e-06	322	51	6	26514267
Pubmed	A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy.	ERAP1 LNPEP	1.26e-05	4	51	2	24957906
Pubmed	Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure.	ERAP1 LNPEP	1.26e-05	4	51	2	17999179
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	EPS15 EXOSC10 PYGB UCK2 WDR1 IPO4 HCFC1	1.69e-05	560	51	7	35241646
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	USP34 ZGPAT MTMR14 RNPEPL1 PYGB TBC1D25 HCFC1 EML3 NSD3	2.92e-05	1105	51	9	35748872
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 EXOSC10 ZNF638 PYGB IPO4 TRIP12 HCFC1	4.50e-05	653	51	7	22586326
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	EPS15 ZNF638 IPO4 ECT2 TRIP12 HCFC1	9.22e-05	503	51	6	16964243
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	USP34 EPS15 EXOSC10 SCYL3 ZNF638 IPO4 TRIP12	1.33e-04	777	51	7	35844135
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ZGPAT EXOSC10 FBXO22 ZNF638 PYGB WDR1 IPO4 ECT2 TRIP12	1.38e-04	1353	51	9	29467282
Pubmed	A feedforward circuit shaped by ECT2 and USP7 contributes to breast carcinogenesis.	ECT2 TRIP12	1.63e-04	13	51	2	32929379
Pubmed	A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome.	CMTR1 RBP3 IPO4	2.34e-04	81	51	3	16110338
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	USP34 TRMT6 ECI2 TRIP12	2.68e-04	212	51	4	33853758
Pubmed	Defining the membrane proteome of NK cells.	EPS15 EXOSC10 ERAP1 LNPEP PYGB ECI2 IPO4 HCFC1	2.79e-04	1168	51	8	19946888
Pubmed	USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.	EXOSC10 PYGB TRIP12	3.19e-04	90	51	3	35654790
Pubmed	EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase.	KIF16B EML3	3.55e-04	19	51	2	18445686
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	EXOSC10 TRMT6 ZNF638 WDR1 IPO4 ECT2 TRIP12 NSD3	4.55e-04	1257	51	8	36526897
Pubmed	The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.	EPS15 LNPEP TRIP12	5.15e-04	106	51	3	31024071
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	USP34 EXOSC10 FBXO22 MTMR14 LNPEP WDR1 IPO4	5.23e-04	974	51	7	28675297
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	EXOSC10 FBXO22 ZNF638 IPO4 ECT2 TRIP12 HCFC1	5.73e-04	989	51	7	36424410
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	CMTR1 ZNF638 UCK2 PRKD1 ECT2	5.75e-04	462	51	5	31138677
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	GPRASP1 FBXO22 RRN3 ECI2 IPO4 TRIP12 HCFC1	6.30e-04	1005	51	7	19615732
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	EXOSC10 ZNF638 TRIP12 HCFC1	7.94e-04	283	51	4	30585729
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	MTMR14 LNPEP SCYL3 KIF16B	8.15e-04	285	51	4	34369648
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	EPS15 LNPEP ZNF638	8.32e-04	125	51	3	29467281
Pubmed	Genome-wide searching of rare genetic variants in WTCCC data.	ZGPAT RNPEPL1	1.02e-03	32	51	2	20549515
Pubmed	TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.	TRIP12 NSD3	1.08e-03	33	51	2	33567268
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	KIF16B ZNF638 IPO4 HCFC1	1.15e-03	313	51	4	38270169
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	USP34 EPS15 TRMT6 LNPEP PYGB WDR1 IPO4 HCFC1	1.18e-03	1455	51	8	22863883
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	PHKB FANCB EPS15 PTTG3P ECT2 HCFC1 EML3	1.41e-03	1155	51	7	20360068
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	EXOSC10 ZNF638 HCFC1 EML3	1.43e-03	332	51	4	32786267
Cytoband	Ensembl 112 genes in cytogenetic band chr1q24	FMO4 SCYL3 UCK2	4.33e-04	129	52	3	chr1q24
Cytoband	1p36.22	EXOSC10 DISP3	8.17e-04	37	52	2	1p36.22
Cytoband	5q15	ERAP1 LNPEP	9.55e-04	40	52	2	5q15
Cytoband	Ensembl 112 genes in cytogenetic band chr5q15	ERAP1 LNPEP	2.07e-03	59	52	2	chr5q15
GeneFamily	Aminopeptidases\|CD molecules	LVRN ERAP1 LNPEP	4.06e-06	17	34	3	104
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	ZGPAT CMTR1	7.74e-04	22	34	2	579
GeneFamily	X-linked mental retardation\|Angiotensin receptors	HCFC1 OPHN1	4.45e-03	53	34	2	103
Drug	Nifedipine [21829-25-4]; Up 200; 11.6uM; PC3; HT_HG-U133A	USP34 ERAP1 RRN3 RPS6KA6 EML3 NSD3	4.64e-06	194	51	6	1814_UP
Disease	endoplasmic reticulum aminopeptidase 1 measurement	ERAP1 LNPEP	5.88e-05	7	50	2	EFO_0008119
Disease	severe pre-eclampsia (is_marker_for)	ERAP1 LNPEP	7.83e-05	8	50	2	DOID:13129 (is_marker_for)
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CAPN8 EML3	1.71e-03	36	50	2	DOID:11723 (implicated_via_orthology)
Disease	lysophosphatidylcholine 20:3 measurement	RRN3 PRKD1	2.11e-03	40	50	2	EFO_0010362
Disease	candidiasis (implicated_via_orthology)	TRMT6 PRKD1	2.54e-03	44	50	2	DOID:1508 (implicated_via_orthology)
Disease	Malignant neoplasm of salivary gland	PYGB PRKD1	2.66e-03	45	50	2	C0220636
Disease	Salivary Gland Neoplasms	PYGB PRKD1	2.90e-03	47	50	2	C0036095
Disease	Adenocarcinoma of lung (disorder)	RPS6KA6 UCK2 IPO4	5.16e-03	206	50	3	C0152013

Protein segments in the cluster

Peptide	Gene	Start	Entry
KEAPFTKFDPSCLFP	CA3	171	P07451
PLFFCIIAPFAKFGK	DISP3	1306	Q9P2K9
VVPSTFEPFKDGEFC	CAPN8	486	A6NHC0
YVFPCFDEPALKATF	LVRN	246	Q6Q4G3
FFPFDLFPMCPFGCQ	ASPN	66	Q9BXN1
TICEFSPFFKKGVFD	KIF16B	1296	Q96L93
FKVPPFQDCILSFLG	ECT2	266	Q9H8V3
LNAFFDPKCPGDVDF	OPHN1	421	O60890
EADAFRKFFPSVPLF	FBXO22	341	Q8NEZ5
PFSEISAFKTCLPGF	HCFC1	1876	P51610
SADPFPQVKLCDFGF	PRKD1	716	Q15139
DFTLLSIPYPGCEFF	MTMR14	241	Q8NCE2
FPCFDEPAFKASFSI	ERAP1	191	Q9NZ08
TFSFPFFEEPLKSLC	FMO4	331	P31512
YLTDPVSDPEFFKGC	DNAH12	2621	Q6ZR08
LDGISSDECPFFIFP	KCNJ13	226	O60928
SAFPCFDEPAFKATF	LNPEP	301	Q9UIQ6
PISGPICAKRAEFFF	JRKL	96	Q9Y4A0
SGKPDDTFCFDPEFT	RPS6KA6	351	Q9UK32
KEFPEVYFCERPGSF	FANCB	686	Q8NB91
ENPFSSIFPKCFFSG	SCYL3	456	Q8IZE3
LPGFPDADSFVKFAL	EXOSC10	26	Q01780
IENSPTPFCVGDKFF	HENMT1	326	Q5T8I9
SPFFTDEFALSKIFP	LINC02876	66	F2Z3M2
EFVGCFIDFPKPLIA	ECI2	226	O75521
FIPCFVFLPDGDILT	EML3	461	Q32P44
PFKGSDPFASDCFFR	EPS15	646	P42566
AIFPEGIFRCLSPKF	ZNF689	26	C0HLU2
KSPELLFDPPFIFFT	CFAP47	1301	Q6ZTR5
FAPFFAGFLPLLVCK	IPO4	851	Q8TEX9
FICKTFDLFTPFSVG	CMTR1	401	Q8N1G2
SFKKFCCFPFGSVPD	PTCHD3	561	Q3KNS1
KLFDGIECEFPIFFL	PHKB	356	Q93100
GFEISFPEFCLKGVT	MTBP	251	Q96DY7
SPFRFPKEAASLFCE	GPRASP1	1066	Q5JY77
LDTFFPFDPCVLKRS	RRN3	556	Q9NYV6
DPELTYGCAKPFVFT	RNPEPL1	181	Q9HAU8
KKCESFLPPEFRSFA	TBC1D25	41	Q3MII6
KLFPFNPLGFESFDL	PTTG3P	116	Q9NZH4
AAFFEGPPFKFKFTI	WDR1	171	O75083
FDGFPFDFQTSCPLI	TECTA	1111	O75443
CSGVIAFFPVFSYKP	TMEM212	21	A6NML5
CSYFFDEGPPVLLDK	RBP3	1096	P10745
ISSGFFSPKEPDCFK	PYGB	746	P11216
ITFVKPAFEEFCLPT	UCK2	186	Q9BZX2
KFPTAIFESKGFRCP	NSD3	781	Q9BZ95
PVRAATACFGFPKSF	TRMT6	236	Q9UJA5
KDCFEYGTPETLPFL	USP34	226	Q70CQ2
LTELGKTCPFFFPFD	TRIP12	1531	Q14669
SLKPCPFFLEGKCRF	ZGPAT	176	Q8N5A5
PEELDFLVPKAGFFC	ZNF638	1916	Q14966
PEDFISKVFFDPCSY	SLC8A3	391	P57103