Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	MKRN3 MKRN4P HERC4 PCGF5 UBE3B MSL2	3.47e-05	372	34	6	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	MKRN3 MKRN4P HERC4 PCGF5 UBE3B MSL2	5.06e-05	398	34	6	GO:0061659
GeneOntologyMolecularFunction	GPI-linked ephrin receptor activity	EPHA7 EPHA8	5.88e-05	7	34	2	GO:0005004
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	MKRN3 MKRN4P HERC4 PCGF5 UBE3B MSL2	1.31e-04	473	34	6	GO:0004842
GeneOntologyMolecularFunction	histone ubiquitin ligase activity	PCGF5 MSL2	1.84e-04	12	34	2	GO:0140852
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	MKRN3 MKRN4P HERC4 PCGF5 UBE3B MSL2	2.02e-04	512	34	6	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	MKRN3 MKRN4P HERC4 PCGF5 UBE3B MSL2	2.48e-04	532	34	6	GO:0016755
GeneOntologyMolecularFunction	acyltransferase activity	MKRN3 MKRN4P HMGCS1 HERC4 PCGF5 UBE3B MSL2	2.78e-04	775	34	7	GO:0016746
GeneOntologyMolecularFunction	transmembrane-ephrin receptor activity	EPHA7 EPHA8	2.91e-04	15	34	2	GO:0005005
GeneOntologyMolecularFunction	ephrin receptor activity	EPHA7 EPHA8	4.73e-04	19	34	2	GO:0005003
GeneOntologyMolecularFunction	protein tyrosine kinase activity	BCR EPHA7 EPHA8	1.90e-03	145	34	3	GO:0004713
GeneOntologyMolecularFunction	nuclear receptor binding	ISL1 PRAMEF1 PRAMEF2	3.91e-03	187	34	3	GO:0016922
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF1 PRAMEF2	3.95e-03	55	34	2	GO:0042974
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	EPHA7 EPHA8	5.47e-03	65	34	2	GO:0004714
Domain	Biotinidase_euk	VNN1 BTD	1.93e-05	4	34	2	IPR012101
Domain	CN_HYDROLASE	VNN1 BTD	8.95e-05	8	34	2	PS50263
Domain	C-N_Hydrolase	VNN1 BTD	8.95e-05	8	34	2	IPR003010
Domain	CN_hydrolase	VNN1 BTD	8.95e-05	8	34	2	PF00795
Domain	-	VNN1 BTD	8.95e-05	8	34	2	3.60.110.10
Domain	RECEPTOR_TYR_KIN_V_2	EPHA7 EPHA8	2.89e-04	14	34	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHA7 EPHA8	2.89e-04	14	34	2	PS00790
Domain	EphA2_TM	EPHA7 EPHA8	2.89e-04	14	34	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHA7 EPHA8	2.89e-04	14	34	2	IPR016257
Domain	Eph_TM	EPHA7 EPHA8	2.89e-04	14	34	2	IPR027936
Domain	Ephrin_rcpt_lig-bd_dom	EPHA7 EPHA8	2.89e-04	14	34	2	IPR001090
Domain	Tyr_kinase_rcpt_V_CS	EPHA7 EPHA8	2.89e-04	14	34	2	IPR001426
Domain	EPH_LBD	EPHA7 EPHA8	2.89e-04	14	34	2	PS51550
Domain	EPH_lbd	EPHA7 EPHA8	2.89e-04	14	34	2	SM00615
Domain	Ephrin_lbd	EPHA7 EPHA8	2.89e-04	14	34	2	PF01404
Domain	PRAME_family	PRAMEF1 PRAMEF2	5.39e-04	19	34	2	IPR026271
Domain	Ephrin_rec_like	EPHA7 EPHA8	9.40e-04	25	34	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHA7 EPHA8	9.40e-04	25	34	2	IPR011641
Domain	HECT	HERC4 UBE3B	1.10e-03	27	34	2	PF00632
Domain	HECTc	HERC4 UBE3B	1.10e-03	27	34	2	SM00119
Domain	HECT_dom	HERC4 UBE3B	1.10e-03	27	34	2	IPR000569
Domain	HECT	HERC4 UBE3B	1.10e-03	27	34	2	PS50237
Domain	ZF_RING_1	MKRN3 MKRN4P PCGF5 MSL2	1.85e-03	291	34	4	PS00518
Domain	ZF_RING_2	MKRN3 MKRN4P PCGF5 MSL2	2.02e-03	298	34	4	PS50089
Domain	Znf_RING	MKRN3 MKRN4P PCGF5 MSL2	2.80e-03	326	34	4	IPR001841
Domain	ZnF_C3H1	MKRN3 MKRN4P	3.44e-03	48	34	2	SM00356
Domain	zf-CCCH	MKRN3 MKRN4P	3.59e-03	49	34	2	PF00642
Domain	Znf_CCCH	MKRN3 MKRN4P	4.99e-03	58	34	2	IPR000571
Domain	SAM_1	EPHA7 EPHA8	6.80e-03	68	34	2	PF00536
Domain	zf-C3HC4	MKRN3 MKRN4P PCGF5	7.65e-03	223	34	3	PF00097
Domain	-	EPHA7 EPHA8	7.80e-03	73	34	2	2.60.120.260
Domain	-	MKRN3 ZFYVE26 PCGF5 MSL2	8.64e-03	449	34	4	3.30.40.10
Domain	Znf_RING/FYVE/PHD	MKRN3 ZFYVE26 PCGF5 MSL2	9.32e-03	459	34	4	IPR013083
Pubmed	An ESTs description of the new Vanin gene family conserved from fly to human.	VNN1 BTD	5.90e-06	4	35	2	10501839
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	ISL1 PRAMEF1 PRAMEF2 ATP5F1A UBE3B TADA2B	1.93e-05	564	35	6	21565611
Pubmed	Profiling Eph receptor expression in cells and tissues: a targeted mass spectrometry approach.	EPHA7 EPHA8	2.74e-05	8	35	2	22568954
Pubmed	Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate.	EPHA7 EPHA8	4.40e-05	10	35	2	25073978
Pubmed	EphrinA5 Signaling Is Required for the Distinctive Targeting of Raphe Serotonin Neurons in the Forebrain.	EPHA7 EPHA8	4.40e-05	10	35	2	28197551
Pubmed	EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes.	EPHA7 EPHA8	4.40e-05	10	35	2	16547242
Pubmed	Expression of ephrin-A ligands and EphA receptors in the developing mouse tooth and its supporting tissues.	EPHA7 EPHA8	5.38e-05	11	35	2	15517401
Pubmed	Ephrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation.	EPHA7 EPHA8	5.38e-05	11	35	2	26644518
Pubmed	Selective inhibition of spinal cord neurite outgrowth and cell survival by the Eph family ligand ephrin-A5.	EPHA7 EPHA8	5.38e-05	11	35	2	10559410
Pubmed	EphrinA-EphA receptor interactions in mouse spinal neurulation: implications for neural fold fusion.	EPHA7 EPHA8	6.45e-05	12	35	2	19247962
Pubmed	Eph-ephrin A system regulates murine blastocyst attachment and spreading.	EPHA7 EPHA8	7.62e-05	13	35	2	17039519
Pubmed	Hypoxia-mediated promotion of glucose metabolism in non-small cell lung cancer correlates with activation of the EZH2/FBXL7/PFKFB4 axis.	HMGCS1 ATP5F1A	7.62e-05	13	35	2	37179372
Pubmed	EphA family gene expression in the developing mouse neocortex: regional patterns reveal intrinsic programs and extrinsic influence.	EPHA7 EPHA8	7.62e-05	13	35	2	12528186
Pubmed	Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue.	EPHA7 EPHA8	8.89e-05	14	35	2	26941654
Pubmed	Genetic loci that control the angiogenic response to basic fibroblast growth factor.	ATP5F1A EPHA7	1.17e-04	16	35	2	15226265
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF1 PRAMEF2	1.33e-04	17	35	2	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF1 PRAMEF2	1.33e-04	17	35	2	37781892
Pubmed	Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice.	EPHA7 EPHA8	1.33e-04	17	35	2	12217323
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF1 PRAMEF2	1.49e-04	18	35	2	29731491
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF1 PRAMEF2	1.49e-04	18	35	2	23894331
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF1 PRAMEF2	1.49e-04	18	35	2	14675769
Pubmed	Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome.	MKRN3 ISL1	1.49e-04	18	35	2	21343540
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF1 PRAMEF2	1.49e-04	18	35	2	12890732
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF1 PRAMEF2	1.49e-04	18	35	2	39181896
Pubmed	Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.	MKRN3 PCGF5 MSL2	1.63e-04	105	35	3	22493164
Pubmed	Expression of Ephs and ephrins in developing mouse inner ear.	EPHA7 EPHA8	1.66e-04	19	35	2	12684176
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF1 PRAMEF2	1.66e-04	19	35	2	28604677
Pubmed	Eph receptors and ephrins: effectors of morphogenesis.	EPHA7 EPHA8	1.85e-04	20	35	2	10207129
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF1 PRAMEF2	1.85e-04	20	35	2	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF1 PRAMEF2	1.85e-04	20	35	2	16580637
Pubmed	Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping.	GJB2 BCR	1.85e-04	20	35	2	1370487
Pubmed	Multiple roles of EPH receptors and ephrins in neural development.	EPHA7 EPHA8	1.85e-04	20	35	2	11256076
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF1 PRAMEF2	1.85e-04	20	35	2	21425410
Pubmed	The Eph family receptors and ligands.	EPHA7 EPHA8	1.85e-04	20	35	2	9576626
Pubmed	The ephrins and Eph receptors in neural development.	EPHA7 EPHA8	1.85e-04	20	35	2	9530499
Pubmed	Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.	EPHA7 EPHA8	2.04e-04	21	35	2	9267020
Pubmed	Developmental expression of Eph and ephrin family genes in mammalian small intestine.	EPHA7 EPHA8	2.04e-04	21	35	2	20112066
Pubmed	Eph receptors and ephrins demarcate cerebellar lobules before and during their formation.	EPHA7 EPHA8	2.04e-04	21	35	2	10495276
Pubmed	Roles of Eph receptors and ephrins in segmental patterning.	EPHA7 EPHA8	2.04e-04	21	35	2	11128993
Pubmed	Eph receptors and ephrins: regulators of guidance and assembly.	EPHA7 EPHA8	2.04e-04	21	35	2	10730216
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF1 PRAMEF2	2.24e-04	22	35	2	31729367
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	MKRN4P TRMT6 HERC4 ATP5F1A	2.36e-04	302	35	4	30561431
Pubmed	Thalamic afferents influence cortical progenitors via ephrin A5-EphA4 interactions.	EPHA7 EPHA8	2.46e-04	23	35	2	25480914
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF1 PRAMEF2	2.46e-04	23	35	2	19480014
Pubmed	Single-cell RNA-sequencing analysis of the developing mouse inner ear identifies molecular logic of auditory neuron diversification.	GJB2 ISL1	2.68e-04	24	35	2	35790771
Pubmed	Eph receptors and their ephrin ligands are expressed in developing mouse pancreas.	EPHA7 EPHA8	2.68e-04	24	35	2	16446123
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF1 PRAMEF2	2.91e-04	25	35	2	37451217
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF1 PRAMEF2	2.91e-04	25	35	2	12620990
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF1 PRAMEF2	3.15e-04	26	35	2	18500982
Pubmed	Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.	ISL1 BCR	3.40e-04	27	35	2	19026994
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF1 PRAMEF2	3.66e-04	28	35	2	25089626
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF1 PRAMEF2	4.20e-04	30	35	2	38786026
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	PRAMEF1 PRAMEF2 HERC4 EPHA7	4.73e-04	363	35	4	14691545
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF1 PRAMEF2	4.79e-04	32	35	2	37889087
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	C16orf96 PRAMEF1 PRAMEF2 PCGF5 ARMCX3	5.40e-04	674	35	5	37196079
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF1 PRAMEF2	5.73e-04	35	35	2	19389355
Pubmed	Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development.	ISL1 EPHA7	6.76e-04	38	35	2	31597102
Pubmed	Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.	EPHA7 EPHA8	8.26e-04	42	35	2	11439183
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	MKRN4P ISL1 PRAMEF1 PRAMEF2	8.46e-04	424	35	4	21731673
Pubmed	Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.	PRAMEF1 PRAMEF2	9.90e-04	46	35	2	17287250
Pubmed	LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.	ISL1 ATP5F1A	9.90e-04	46	35	2	35237793
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHA7 EPHA8	1.40e-04	14	23	2	1095
GeneFamily	Ring finger proteins	MKRN3 MKRN4P PCGF5 MSL2	3.69e-04	275	23	4	58
GeneFamily	PRAME family	PRAMEF1 PRAMEF2	4.20e-04	24	23	2	686
GeneFamily	Sterile alpha motif domain containing	EPHA7 EPHA8	5.54e-03	88	23	2	760
Disease	Metastatic melanoma	EPHA7 EPHA8	1.67e-03	54	33	2	C0278883
Disease	Psoriasis	GJB2 VNN1	1.86e-03	57	33	2	C0033860
Disease	Pustulosis of Palms and Soles	GJB2 VNN1	1.86e-03	57	33	2	C0030246

Protein segments in the cluster

Peptide	Gene	Start	Entry
CYIRKRCLKLKSPYN	EPGN	131	Q6UW88
TCCLKYYEKVLPRRL	CCL16	36	O15467
CLDTKGKENRLCYYL	CDNF	71	Q49AH0
TLRILCYEKCYNKTK	BCR	971	P11274
CYLLIRYCSGKSKKP	GJB2	211	P29033
SGLLYKFCQTIKCRA	PKD1L1-AS1	46	Q9H7B7
CYCIYRLTRGRKQNK	ARMCX3	21	Q9UH62
KLYCIYVAIGQKRST	ATP5F1A	241	P25705
LSALDRCYSVYCKKI	HMGCS1	226	Q01581
TKQVTCRYFKYGICK	MKRN4P	91	Q13434
ITCYICKGYLIKPTT	PCGF5	16	Q86SE9
CRLCYKQLKSISGLV	KATNB1	616	Q9BVA0
LKSLRSQKIVYICCG	HERC4	236	Q5GLZ8
ACIALVSVKVYYKKC	EPHA7	191	Q15375
LSILVNCYKKLCEYI	MSL2	96	Q9HCI7
LKCKSCNLLTLYPYG	C16orf96	986	A6NNT2
CLAILSLRIYYKKCP	EPHA8	191	P29322
GLCCYLLYERPTLSK	BTD	421	P43251
RCYGILTCSKYCKTK	ANKMY1	896	Q9P2S6
CSKYSYKGLKSICIY	DDX53	316	Q86TM3
KKYCVYCLAEVSPLR	TADA2B	6	Q86TJ2
RKECYYLTCQLYALK	SGO1	86	Q5FBB7
YLTCQLYALKGKLTS	SGO1	91	Q5FBB7
IGICYAVCEYLLSLK	MSH4	771	O15457
CCSKLVNYLTPIKYL	PRAMEF1	181	O95521
YLALTCIYTKKRGQR	DRG2	286	P55039
YIRLYGIKCAKCSIG	ISL1	71	P61371
CCSKLVNYLTPIKYL	PRAMEF2	181	O60811
GRYYLQICTLLKCKT	VNN1	391	O95497
TKQIICRYYIHGQCK	MKRN3	96	Q13064
KFLYSVGLTRKCLCR	MTERF1	181	Q99551
KRSIIFLLCVYTKGC	ZNF844	621	Q08AG5
CQYKEPLLECYTKLR	TRMT6	401	Q9UJA5
TLCYCRKYVSQKKSN	UBE3B	341	Q7Z3V4
YKGIKCTTSSLIYQR	ZNF674	336	Q2M3X9
YLICCKLRSAYLIAV	ZFYVE26	2476	Q68DK2