Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionfrizzled binding

DVL2 DVL3 WNT3A DVL1

5.10e-0742314GO:0005109
GeneOntologyMolecularFunctionG protein-coupled receptor binding

DVL2 DVL3 WNT3A DVL1

1.75e-03337314GO:0001664
GeneOntologyMolecularFunctionGTPase binding

DVL2 DVL3 AMBRA1 DVL1

2.23e-03360314GO:0051020
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1A RYR1

2.31e-0346312GO:0005245
GeneOntologyBiologicalProcesspositive regulation of neuron projection arborization

DVL2 DVL3 DVL1

1.39e-078293GO:0150012
GeneOntologyBiologicalProcessregulation of establishment of planar polarity involved in neural tube closure

DVL2 DVL3 DVL1

1.12e-0615293GO:0090178
GeneOntologyBiologicalProcessregulation of neuron projection arborization

DVL2 DVL3 DVL1

1.12e-0615293GO:0150011
GeneOntologyBiologicalProcessestablishment of planar polarity involved in neural tube closure

DVL2 DVL3 DVL1

1.38e-0616293GO:0090177
GeneOntologyBiologicalProcessestablishment of planar polarity of embryonic epithelium

DVL2 DVL3 DVL1

2.01e-0618293GO:0042249
GeneOntologyBiologicalProcessear morphogenesis

DVL2 DVL3 WNT3A NAGLU DVL1

2.23e-06154295GO:0042471
GeneOntologyBiologicalProcessregulation of establishment of planar polarity

DVL2 DVL3 DVL1

2.39e-0619293GO:0090175
GeneOntologyBiologicalProcessnon-canonical Wnt signaling pathway

DVL2 DVL3 WNT3A DVL1

3.97e-0677294GO:0035567
GeneOntologyBiologicalProcessheart morphogenesis

DVL2 DVL3 WNT3A RYR1 NAGLU DVL1

4.76e-06321296GO:0003007
GeneOntologyBiologicalProcessneural tube development

DVL2 DVL3 AMBRA1 WNT3A DVL1

8.41e-06202295GO:0021915
GeneOntologyBiologicalProcessoutflow tract morphogenesis

DVL2 DVL3 RYR1 DVL1

8.80e-0694294GO:0003151
GeneOntologyBiologicalProcesscochlea morphogenesis

DVL2 DVL3 DVL1

8.91e-0629293GO:0090103
GeneOntologyBiologicalProcessneural plate elongation

DVL2 DVL1

1.14e-054292GO:0014022
GeneOntologyBiologicalProcessconvergent extension involved in neural plate elongation

DVL2 DVL1

1.14e-054292GO:0022007
GeneOntologyBiologicalProcessregulation of animal organ morphogenesis

DVL2 DVL3 WNT3A DVL1

1.64e-05110294GO:2000027
GeneOntologyBiologicalProcessneuron projection arborization

DVL2 DVL3 DVL1

2.04e-0538293GO:0140058
GeneOntologyBiologicalProcessinner ear development

DVL2 DVL3 WNT3A NAGLU DVL1

2.49e-05253295GO:0048839
GeneOntologyBiologicalProcessinner ear morphogenesis

DVL2 DVL3 WNT3A DVL1

3.07e-05129294GO:0042472
GeneOntologyBiologicalProcessestablishment of planar polarity

DVL2 DVL3 DVL1

3.18e-0544293GO:0001736
GeneOntologyBiologicalProcessestablishment of tissue polarity

DVL2 DVL3 DVL1

3.41e-0545293GO:0007164
GeneOntologyBiologicalProcessconvergent extension involved in organogenesis

DVL2 DVL1

3.99e-057292GO:0060029
GeneOntologyBiologicalProcessear development

DVL2 DVL3 WNT3A NAGLU DVL1

4.40e-05285295GO:0043583
GeneOntologyBiologicalProcessWnt signaling pathway, planar cell polarity pathway

DVL2 DVL3 DVL1

6.24e-0555293GO:0060071
GeneOntologyBiologicalProcessheart development

DVL2 DVL3 INHBA WNT3A RYR1 NAGLU DVL1

6.72e-05757297GO:0007507
GeneOntologyBiologicalProcessneural plate morphogenesis

DVL2 DVL1

6.83e-059292GO:0001839
GeneOntologyBiologicalProcesscochlea development

DVL2 DVL3 DVL1

8.51e-0561293GO:0090102
GeneOntologyBiologicalProcessconvergent extension involved in gastrulation

DVL2 DVL1

1.04e-0411292GO:0060027
GeneOntologyBiologicalProcesssensory organ morphogenesis

DVL2 DVL3 WNT3A NAGLU DVL1

1.06e-04343295GO:0090596
GeneOntologyBiologicalProcessembryonic organ morphogenesis

DVL2 DVL3 WNT3A NAGLU DVL1

1.18e-04351295GO:0048562
GeneOntologyBiologicalProcessheart looping

DVL2 WNT3A DVL1

1.45e-0473293GO:0001947
GeneOntologyBiologicalProcessmorphogenesis of a polarized epithelium

DVL2 DVL3 DVL1

1.45e-0473293GO:0001738
GeneOntologyBiologicalProcessneural plate development

DVL2 DVL1

1.72e-0414292GO:0001840
GeneOntologyBiologicalProcessdetermination of heart left/right asymmetry

DVL2 WNT3A DVL1

1.84e-0479293GO:0061371
GeneOntologyBiologicalProcessembryonic heart tube morphogenesis

DVL2 WNT3A DVL1

1.91e-0480293GO:0003143
GeneOntologyBiologicalProcessgastrulation

DVL2 INHBA WNT3A DVL1

2.11e-04212294GO:0007369
GeneOntologyBiologicalProcessanimal organ morphogenesis

DVL2 DVL3 SRSF6 INHBA WNT3A RYR1 NAGLU DVL1

2.69e-041269298GO:0009887
GeneOntologyBiologicalProcessmidbrain dopaminergic neuron differentiation

DVL3 WNT3A

2.88e-0418292GO:1904948
GeneOntologyBiologicalProcessconvergent extension

DVL2 DVL1

3.22e-0419292GO:0060026
GeneOntologyBiologicalProcessembryonic morphogenesis

DVL2 DVL3 INHBA WNT3A NAGLU DVL1

4.02e-04713296GO:0048598
GeneOntologyBiologicalProcessembryonic heart tube development

DVL2 WNT3A DVL1

4.02e-04103293GO:0035050
GeneOntologyBiologicalProcesssensory organ development

DVL2 DVL3 INHBA WNT3A NAGLU DVL1

4.55e-04730296GO:0007423
GeneOntologyBiologicalProcesssynaptic vesicle cycle

CACNA1A SNAP47 WNT3A DVL1

4.84e-04264294GO:0099504
GeneOntologyBiologicalProcesstissue morphogenesis

DVL2 DVL3 INHBA WNT3A NAGLU DVL1

5.26e-04750296GO:0048729
GeneOntologyBiologicalProcessneural tube closure

DVL2 DVL3 DVL1

5.27e-04113293GO:0001843
GeneOntologyBiologicalProcesstube closure

DVL2 DVL3 DVL1

5.41e-04114293GO:0060606
GeneOntologyBiologicalProcessnegative regulation of mRNA metabolic process

FXR1 SRSF4 SRSF6

5.55e-04115293GO:1903312
GeneOntologyBiologicalProcessprimary neural tube formation

DVL2 DVL3 DVL1

6.28e-04120293GO:0014020
GeneOntologyBiologicalProcesspositive regulation of protein metabolic process

DVL2 DVL3 AMBRA1 FXR1 LARP4 INHBA WNT3A DVL1

6.86e-041458298GO:0051247
GeneOntologyBiologicalProcessnegative regulation of mRNA splicing, via spliceosome

SRSF4 SRSF6

7.05e-0428292GO:0048025
GeneOntologyBiologicalProcesssynaptic vesicle exocytosis

CACNA1A SNAP47 DVL1

7.08e-04125293GO:0016079
GeneOntologyBiologicalProcessepithelium development

DVL2 DVL3 AMBRA1 SRSF6 INHBA WNT3A NAGLU DVL1

7.21e-041469298GO:0060429
GeneOntologyBiologicalProcessnegative regulation of mRNA processing

SRSF4 SRSF6

7.57e-0429292GO:0050686
GeneOntologyBiologicalProcessregulation of cell morphogenesis

DVL2 DVL3 LARP4 DVL1

8.02e-04302294GO:0022604
GeneOntologyBiologicalProcessneural tube formation

DVL2 DVL3 DVL1

8.66e-04134293GO:0001841
GeneOntologyBiologicalProcessnegative regulation of RNA splicing

SRSF4 SRSF6

9.81e-0433292GO:0033119
GeneOntologyBiologicalProcessvesicle-mediated transport in synapse

CACNA1A SNAP47 WNT3A DVL1

1.01e-03321294GO:0099003
GeneOntologyBiologicalProcessembryonic organ development

DVL2 DVL3 WNT3A NAGLU DVL1

1.01e-03561295GO:0048568
GeneOntologyBiologicalProcessbrain development

DVL3 CACNA1A FXR1 INHBA WNT3A NAGLU

1.07e-03859296GO:0007420
GeneOntologyBiologicalProcesscell junction assembly

CACNA1A MARVELD3 WNT3A GJD3 DVL1

1.08e-03569295GO:0034329
GeneOntologyBiologicalProcessmesodermal cell differentiation

INHBA WNT3A

1.10e-0335292GO:0048333
GeneOntologyBiologicalProcesspositive regulation of protein tyrosine kinase activity

DVL2 WNT3A

1.10e-0335292GO:0061098
GeneOntologyBiologicalProcessprotein localization to cell junction

MARVELD3 SNAP47 DVL1

1.15e-03148293GO:1902414
GeneOntologyBiologicalProcesspositive regulation of phosphate metabolic process

DVL2 DVL3 AMBRA1 INHBA WNT3A DVL1

1.21e-03879296GO:0045937
GeneOntologyBiologicalProcesspositive regulation of phosphorus metabolic process

DVL2 DVL3 AMBRA1 INHBA WNT3A DVL1

1.21e-03879296GO:0010562
GeneOntologyBiologicalProcesscollateral sprouting

WNT3A DVL1

1.23e-0337292GO:0048668
GeneOntologyBiologicalProcessdetermination of left/right symmetry

DVL2 WNT3A DVL1

1.29e-03154293GO:0007368
GeneOntologyBiologicalProcesscanonical Wnt signaling pathway

DVL2 DVL3 WNT3A DVL1

1.30e-03344294GO:0060070
GeneOntologyBiologicalProcesscerebellar Purkinje cell layer development

CACNA1A NAGLU

1.37e-0339292GO:0021680
GeneOntologyBiologicalProcessembryonic epithelial tube formation

DVL2 DVL3 DVL1

1.42e-03159293GO:0001838
GeneOntologyBiologicalProcessregulation of JNK cascade

DVL2 DVL3 MARVELD3

1.47e-03161293GO:0046328
GeneOntologyBiologicalProcessleft/right pattern formation

DVL2 WNT3A DVL1

1.50e-03162293GO:0060972
GeneOntologyBiologicalProcesshead development

DVL3 CACNA1A FXR1 INHBA WNT3A NAGLU

1.52e-03919296GO:0060322
GeneOntologyBiologicalProcessmorphogenesis of an epithelium

DVL2 DVL3 WNT3A NAGLU DVL1

1.56e-03619295GO:0002009
GeneOntologyBiologicalProcessdetermination of bilateral symmetry

DVL2 WNT3A DVL1

1.58e-03165293GO:0009855
GeneOntologyBiologicalProcessspecification of symmetry

DVL2 WNT3A DVL1

1.58e-03165293GO:0009799
GeneOntologyBiologicalProcesspositive regulation of protein modification process

DVL2 DVL3 AMBRA1 INHBA WNT3A DVL1

1.67e-03937296GO:0031401
GeneOntologyBiologicalProcessskin development

SRSF6 INHBA RYR1 NAGLU

1.75e-03373294GO:0043588
GeneOntologyBiologicalProcessepithelial tube formation

DVL2 DVL3 DVL1

1.80e-03173293GO:0072175
GeneOntologyBiologicalProcessubiquitin-dependent protein catabolic process

AMBRA1 MARVELD3 RNF187 NAGLU DVL1

1.81e-03640295GO:0006511
GeneOntologyBiologicalProcessmodification-dependent protein catabolic process

AMBRA1 MARVELD3 RNF187 NAGLU DVL1

1.95e-03651295GO:0019941
GeneOntologyBiologicalProcessmodification-dependent macromolecule catabolic process

AMBRA1 MARVELD3 RNF187 NAGLU DVL1

2.02e-03656295GO:0043632
GeneOntologyBiologicalProcessstriated muscle cell differentiation

GDF15 WNT3A RYR1 NAGLU

2.08e-03391294GO:0051146
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

CACNA1A FXR1 SNAP47 WNT3A DVL1

2.12e-03663295GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

CACNA1A FXR1 SNAP47 WNT3A DVL1

2.13e-03664295GO:0099177
GeneOntologyBiologicalProcessdopaminergic neuron differentiation

DVL3 WNT3A

2.24e-0350292GO:0071542
GeneOntologyBiologicalProcesstube formation

DVL2 DVL3 DVL1

2.25e-03187293GO:0035148
GeneOntologyBiologicalProcessmorphogenesis of embryonic epithelium

DVL2 DVL3 DVL1

2.36e-03190293GO:0016331
GeneOntologyBiologicalProcesssignal release from synapse

CACNA1A SNAP47 DVL1

2.54e-03195293GO:0099643
GeneOntologyBiologicalProcessneurotransmitter secretion

CACNA1A SNAP47 DVL1

2.54e-03195293GO:0007269
GeneOntologyBiologicalProcessJNK cascade

DVL2 DVL3 MARVELD3

2.65e-03198293GO:0007254
GeneOntologyBiologicalProcessepithelial tube morphogenesis

DVL2 DVL3 WNT3A DVL1

2.71e-03421294GO:0060562
GeneOntologyBiologicalProcesstube development

DVL2 DVL3 AMBRA1 SRSF6 WNT3A NAGLU DVL1

2.74e-031402297GO:0035295
GeneOntologyBiologicalProcessproteasome-mediated ubiquitin-dependent protein catabolic process

AMBRA1 RNF187 NAGLU DVL1

2.78e-03424294GO:0043161
GeneOntologyCellularComponentWnt signalosome

DVL3 WNT3A DVL1

1.63e-0616313GO:1990909
HumanPhenoNaevus flammeus of the eyelid

DVL3 DVL1

4.52e-05782HP:0010733
HumanPhenoMinicore myopathy

FXR1 RYR1

7.73e-05982HP:0003789
HumanPhenoEuryblepharon

DVL3 DVL1

7.73e-05982HP:0012905
HumanPhenoRidged fingernail

DVL3 DVL1

7.73e-05982HP:0008402
HumanPhenoOnychogryposis of fingernail

DVL3 DVL1

7.73e-05982HP:0040036
HumanPhenoAbnormal sarcomere morphology

FXR1 RYR1

1.95e-041482HP:0020201
HumanPhenoCurly eyelashes

DVL3 DVL1

2.24e-041582HP:0007665
HumanPhenoFingernail dysplasia

DVL3 DVL1

2.56e-041682HP:0100798
HumanPhenoMuscle fibrillation

CACNA1A FXR1 RYR1

3.50e-049783HP:0010546
HumanPhenoAnodontia

DVL3 DVL1

3.64e-041982HP:0000674
HumanPhenoFemoral hernia

DVL3 DVL1

4.04e-042082HP:0100541
HumanPhenoTriangular mouth

DVL3 DVL1

4.04e-042082HP:0000207
DomainDishevelled

DVL2 DVL3 DVL1P1 DVL1

5.41e-124304PF02377
DomainDishevelled_protein_dom

DVL2 DVL3 DVL1P1 DVL1

5.41e-124304IPR003351
DomainDishevelled_fam

DVL2 DVL3 DVL1P1 DVL1

5.41e-124304IPR008339
DomainDIX

DVL2 DVL3 DVL1P1 DVL1

1.89e-107304IPR001158
DomainDIX

DVL2 DVL3 DVL1P1 DVL1

1.89e-107304PS50841
DomainDAX

DVL2 DVL3 DVL1P1 DVL1

1.89e-107304SM00021
DomainDIX

DVL2 DVL3 DVL1P1 DVL1

1.89e-107304PF00778
DomainDsh_C

DVL2 DVL3 DVL1

3.74e-093303PF12316
DomainDishevelled_C-dom

DVL2 DVL3 DVL1

3.74e-093303IPR024580
DomainDsh/Dvl-rel

DVL2 DVL3 DVL1

1.49e-084303IPR015506
DomainDEP

DVL2 DVL3 DVL1P1 DVL1

3.88e-0822304PF00610
DomainDEP

DVL2 DVL3 DVL1P1 DVL1

3.88e-0822304SM00049
DomainDEP

DVL2 DVL3 DVL1P1 DVL1

3.88e-0822304PS50186
DomainDEP_dom

DVL2 DVL3 DVL1P1 DVL1

4.69e-0823304IPR000591
DomainDVL-1

DVL1P1 DVL1

2.49e-062302IPR008340
DomainPDZ

DVL2 DVL3 DVL1P1 PDZD4 DVL1

2.80e-06141305PF00595
DomainPDZ

DVL2 DVL3 DVL1P1 PDZD4 DVL1

3.55e-06148305SM00228
DomainPDZ

DVL2 DVL3 DVL1P1 PDZD4 DVL1

3.91e-06151305PS50106
DomainPDZ

DVL2 DVL3 DVL1P1 PDZD4 DVL1

4.04e-06152305IPR001478
DomainWHTH_DNA-bd_dom

DVL2 DVL3 DVL1P1 LARP4 DVL1

3.83e-05242305IPR011991
Domain-

DVL2 DVL3 PDZD4 DVL1

9.31e-051503042.30.42.10
Domain-

DVL2 DVL3 LARP4 DVL1

3.90e-042183041.10.10.10
DomainFA58C

CNTNAP3 CNTNAP3B

5.14e-0421302SM00231
DomainFA58C_3

CNTNAP3 CNTNAP3B

5.14e-0421302PS50022
DomainFA58C_1

CNTNAP3 CNTNAP3B

5.14e-0421302PS01285
DomainFA58C_2

CNTNAP3 CNTNAP3B

5.14e-0421302PS01286
DomainF5_F8_type_C

CNTNAP3 CNTNAP3B

6.73e-0424302PF00754
DomainFA58C

CNTNAP3 CNTNAP3B

6.73e-0424302IPR000421
DomainTGF-beta-rel

INHBA GDF15

1.20e-0332302IPR015615
DomainFibrinogen_a/b/g_C_dom

CNTNAP3 CNTNAP3B

1.20e-0332302IPR002181
DomainFIBRINOGEN_C_2

CNTNAP3 CNTNAP3B

1.20e-0332302PS51406
DomainFIBRINOGEN_C_1

CNTNAP3 CNTNAP3B

1.20e-0332302PS00514
DomainTGFB

INHBA GDF15

1.60e-0337302SM00204
DomainTGF_BETA_2

INHBA GDF15

1.60e-0337302PS51362
DomainTGF_beta

INHBA GDF15

1.60e-0337302PF00019
DomainTGF-b_C

INHBA GDF15

1.60e-0337302IPR001839
DomainTGF_BETA_1

INHBA GDF15

1.60e-0337302PS00250
DomainLAM_G_DOMAIN

CNTNAP3 CNTNAP3B

1.69e-0338302PS50025
DomainLaminin_G_2

CNTNAP3 CNTNAP3B

1.87e-0340302PF02210
DomainLamG

CNTNAP3 CNTNAP3B

2.26e-0344302SM00282
DomainUbiquitin-rel_dom

DVL2 DVL3 DVL1

3.14e-03184303IPR029071
DomainLaminin_G

CNTNAP3 CNTNAP3B

3.90e-0358302IPR001791
DomainRRM

SRSF4 SRSF6 LARP4

4.98e-03217303SM00360
DomainConA-like_dom

CNTNAP3 CNTNAP3B RYR1

5.11e-03219303IPR013320
Domain-

INHBA GDF15

5.17e-03673022.10.90.10
DomainCystine-knot_cytokine

INHBA GDF15

5.17e-0367302IPR029034
DomainRRM_dom

SRSF4 SRSF6 LARP4

5.65e-03227303IPR000504
DomainRRM

SRSF4 SRSF6 LARP4

5.86e-03230303PS50102
Domain-

SRSF4 SRSF6 LARP4

6.89e-032443033.30.70.330
DomainNucleotide-bd_a/b_plait

SRSF4 SRSF6 LARP4

8.03e-03258303IPR012677
DomainGalactose-bd-like

CNTNAP3 CNTNAP3B

9.95e-0394302IPR008979
PathwayPID_BETA_CATENIN_DEG_PATHWAY

DVL2 DVL3 WNT3A DVL1

8.90e-0918204M31
PathwayPID_WNT_CANONICAL_PATHWAY

DVL2 DVL3 WNT3A DVL1

1.41e-0820204M90
PathwayREACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_DVL_INTERACTING_PROTEINS

DVL2 DVL3 DVL1

2.44e-085203M27447
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

DVL2 DVL3 WNT3A DVL1

9.04e-0831204M27400
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

DVL2 DVL3 WNT3A DVL1

9.04e-0831204MM15154
PathwayREACTOME_WNT_MEDIATED_ACTIVATION_OF_DVL

DVL2 DVL3 DVL1

1.36e-078203M27100
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

DVL2 DVL3 WNT3A DVL1

1.69e-0736204M39699
PathwayKEGG_MEDICUS_VARIANT_FZD7_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

DVL2 DVL3 WNT3A DVL1

1.89e-0737204M47411
PathwayREACTOME_WNT_MEDIATED_ACTIVATION_OF_DVL

DVL2 DVL3 DVL1

2.04e-079203MM14792
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

DVL2 DVL3 WNT3A DVL1

3.86e-0744204MM15878
PathwayKEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

DVL2 DVL3 WNT3A DVL1

4.23e-0745204M47412
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY

DVL2 DVL3 WNT3A DVL1

4.63e-0746204M47409
PathwayREACTOME_KILLING_MECHANISMS

DVL2 DVL3 DVL1

5.33e-0712203M29844
PathwayKEGG_BASAL_CELL_CARCINOMA

DVL2 DVL3 WNT3A DVL1

9.59e-0755204M17807
PathwayKEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY

DVL2 DVL3 DVL1

1.35e-0616203M47823
PathwayWP_WNT_SIGNALING

DVL2 DVL3 WNT3A DVL1

1.46e-0661204MM15893
PathwayWP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY

DVL2 DVL3 WNT3A DVL1

5.54e-0685204M48315
PathwayWP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA

DVL2 DVL3 WNT3A DVL1

6.66e-0689204M39563
PathwayWP_NEURAL_CREST_DIFFERENTIATION

DVL2 DVL3 WNT3A DVL1

9.38e-0697204MM15926
PathwayWP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER

DVL2 DVL3 WNT3A DVL1

9.77e-0698204M39731
PathwayWP_NEURAL_CREST_DIFFERENTIATION

DVL2 DVL3 WNT3A DVL1

1.10e-05101204M39448
PathwayWP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY

DVL2 DVL3 WNT3A DVL1

1.10e-05101204MM15829
PathwayKEGG_MELANOGENESIS

DVL2 DVL3 WNT3A DVL1

1.10e-05101204M7761
PathwayWP_WNT_SIGNALING_AND_PLURIPOTENCY

DVL2 DVL3 WNT3A DVL1

1.10e-05101204M39387
PathwayPID_WNT_NONCANONICAL_PATHWAY

DVL2 DVL3 DVL1

1.18e-0532203M23
PathwayWP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT

DVL2 DVL3 WNT3A DVL1

1.54e-05110204M39492
PathwayWP_WNT_SIGNALING_PATHWAY

DVL2 DVL3 WNT3A DVL1

1.54e-05110204MM15977
PathwayWP_WNT_SIGNALING_WP428

DVL2 DVL3 WNT3A DVL1

1.72e-05113204M39669
PathwayWP_ESC_PLURIPOTENCY_PATHWAYS

DVL2 DVL3 WNT3A DVL1

1.90e-05116204MM15863
PathwayWP_EMBRYONIC_STEM_CELL_PLURIPOTENCY_PATHWAYS

DVL2 DVL3 WNT3A DVL1

1.97e-05117204M39530
PathwayWP_ALZHEIMERS_DISEASE

DVL2 DVL3 AMBRA1 WNT3A DVL1

2.59e-05261205M42565
PathwayWP_NOTCH_SIGNALING_WP268

DVL2 DVL3 DVL1

3.34e-0545203M39571
PathwayWP_NOTCH_SIGNALING_PATHWAY

DVL2 DVL3 DVL1

3.57e-0546203MM15971
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

DVL2 DVL3 DVL1

3.81e-0547203M7946
PathwayWP_WNT_SIGNALING_WP363

DVL2 DVL3 DVL1

4.87e-0551203M39721
PathwayKEGG_WNT_SIGNALING_PATHWAY

DVL2 DVL3 WNT3A DVL1

5.36e-05151204M19428
PathwayWP_BREAST_CANCER_PATHWAY

DVL2 DVL3 WNT3A DVL1

5.79e-05154204M39739
PathwayREACTOME_DEGRADATION_OF_DVL

DVL2 DVL3 DVL1

6.11e-0555203MM15153
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

DVL2 DVL3 WNT3A DVL1

6.40e-05158204MM14791
PathwayREACTOME_DEGRADATION_OF_DVL

DVL2 DVL3 DVL1

6.80e-0557203M27399
PathwayWP_ALZHEIMERS_DISEASE_AND_MIRNA_EFFECTS

DVL2 DVL3 AMBRA1 WNT3A DVL1

7.47e-05326205M39379
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

CACNA1A RYR1

1.04e-0411202M47958
PathwayREACTOME_PCP_CE_PATHWAY

DVL2 DVL3 DVL1

2.24e-0485203MM15041
PathwayWNT_SIGNALING

DVL2 WNT3A DVL1

2.57e-0489203M5493
PathwayREACTOME_PCP_CE_PATHWAY

DVL2 DVL3 DVL1

2.83e-0492203M27322
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

DVL2 DVL3 WNT3A DVL1

2.86e-04233204M27099
PathwayREACTOME_SIGNALING_BY_WNT

DVL2 DVL3 WNT3A DVL1

3.15e-04239204MM14756
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

DVL2 DVL3 DVL1

6.63e-04123203MM14988
PathwayREACTOME_RHO_GTPASES_ACTIVATE_FORMINS

DVL2 DVL3 DVL1

9.66e-04140203M27550
PathwayREACTOME_RHO_GTPASES_ACTIVATE_FORMINS

DVL2 DVL3 DVL1

9.86e-04141203MM15266
PathwayKEGG_PATHWAYS_IN_CANCER

DVL2 DVL3 WNT3A DVL1

1.00e-03325204M12868
PathwayREACTOME_SIGNALING_BY_WNT

DVL2 DVL3 WNT3A DVL1

1.06e-03330204M7847
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

DVL2 DVL3 DVL1

1.09e-03146203M27288
PathwayWP_MICROTUBULE_CYTOSKELETON_REGULATION

WNT3A DVL1

2.07e-0348202M39566
PathwayWP_PLURIPOTENT_STEM_CELL_DIFFERENTIATION_PATHWAY

INHBA WNT3A

2.07e-0348202M39427
PathwayWP_CARDIAC_PROGENITOR_DIFFERENTIATION

INHBA WNT3A

2.52e-0353202M39681
PathwayWP_PLEURAL_MESOTHELIOMA

DVL2 DVL3 WNT3A DVL1

3.02e-03439204M42563
PathwayREACTOME_LEISHMANIA_INFECTION

DVL2 DVL3 DVL1

3.47e-03219203M29836
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION_TERMINATION

SRSF4 SRSF6

4.00e-0367202M27694
PathwayKEGG_LONG_TERM_DEPRESSION

CACNA1A RYR1

4.36e-0370202M8232
PathwayWP_CANCER_PATHWAYS

DVL2 DVL3 WNT3A DVL1

5.06e-03507204M48302
PathwayWP_JOUBERT_SYNDROME

DVL3 DVL1

5.12e-0376202M39835
PathwayREACTOME_RHO_GTPASE_EFFECTORS

DVL2 DVL3 DVL1

5.43e-03257203MM14755
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

SRSF4 SRSF6

6.22e-0384202M725
PathwayWP_MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY

WNT3A DVL1

8.54e-0399202MM15905
PathwayWP_MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY

WNT3A DVL1

9.39e-03104202M39625
PathwayREACTOME_RHO_GTPASE_EFFECTORS

DVL2 DVL3 DVL1

1.02e-02323203M27080
PathwayWP_1P36_COPY_NUMBER_VARIATION_SYNDROME

MORN1 DVL1

1.08e-02112202M48072
Pubmed

cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.

DVL2 DVL3 DVL1P1 DVL1

6.71e-1343348817329
Pubmed

Human dishevelled genes constitute a DHR-containing multigene family.

DVL2 DVL3 DVL1P1 DVL1

6.71e-1343349192851
Pubmed

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.

DVL2 DVL3 WNT3A DVL1

4.69e-11833415454084
Pubmed

Regulation of the Wnt signaling pathway by disabled-2 (Dab2).

DVL2 DVL3 WNT3A DVL1

8.43e-11933412805222
Pubmed

The Hippo pathway regulates Wnt/beta-catenin signaling.

DVL2 DVL3 WNT3A DVL1

4.77e-101333420412773
Pubmed

Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling.

DVL2 DVL3 DVL1

7.78e-10333321092292
Pubmed

Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3.

DVL2 DVL3 DVL1

7.78e-10333318093802
Pubmed

Genomic organization of mouse Dishevelled genes.

DVL2 DVL3 DVL1

7.78e-1033338973355
Pubmed

Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression.

DVL2 DVL3 DVL1

7.78e-10333318692936
Pubmed

DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway.

DVL2 DVL3 DVL1

7.78e-10333332900645
Pubmed

Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.

DVL2 DVL3 DVL1

7.78e-10333327744318
Pubmed

Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia.

DVL2 DVL3 DVL1

7.78e-10333327086035
Pubmed

Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals.

DVL2 DVL3 DVL1

7.78e-10333323437169
Pubmed

Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway.

DVL2 WNT3A DVL1

7.78e-10333310409711
Pubmed

Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak.

DVL2 DVL3 WNT3A DVL1

2.04e-091833419701191
Pubmed

Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.

DVL2 DVL3 DVL1

3.11e-09433324643799
Pubmed

DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.

DVL2 DVL3 DVL1

3.11e-09433325557784
Pubmed

Molecular basis of Wnt activation via the DIX domain protein Ccd1.

DVL2 WNT3A DVL1

3.11e-09433321189423
Pubmed

Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways.

DVL2 DVL3 DVL1

3.11e-09433317593335
Pubmed

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways.

DVL2 DVL3 DVL1

3.11e-09433319625296
Pubmed

Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus.

DVL2 DVL3 DVL1

3.11e-09433325043421
Pubmed

Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein.

DVL2 DVL3 DVL1

3.11e-09433319465938
Pubmed

Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling.

DVL2 DVL3 DVL1

3.11e-09433323371553
Pubmed

Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation.

DVL2 DVL3 DVL1

3.11e-09433318772438
Pubmed

Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled.

DVL2 DVL3 WNT3A

7.77e-09533320137080
Pubmed

Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.

DVL2 DVL3 DVL1

7.77e-09533315456783
Pubmed

A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.

DVL2 DVL3 DVL1

7.77e-09533325424568
Pubmed

CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation.

DVL2 DVL3 DVL1

7.77e-09533324469800
Pubmed

The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.

DVL2 DVL3 DVL1

7.77e-09533322826439
Pubmed

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.

DVL3 WNT3A DVL1

7.77e-09533320227366
Pubmed

Deletion of the Dishevelled family of genes disrupts anterior-posterior axis specification and selectively prevents mesoderm differentiation.

DVL2 DVL3 DVL1

1.55e-08633332579954
Pubmed

Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.

DVL2 DVL3 DVL1

1.55e-08633334139860
Pubmed

Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation.

DVL2 DVL3 DVL1

1.55e-08633321880741
Pubmed

SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.

DVL2 DVL3 DVL1

1.55e-08633320439735
Pubmed

USP42 protects ZNRF3/RNF43 from R-spondin-dependent clearance and inhibits Wnt signalling.

DVL2 USP42 DVL1

2.72e-08733333786993
Pubmed

Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells.

DVL2 DVL3 DVL1

2.72e-08733310806215
Pubmed

Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.

DVL2 DVL3 DVL1

2.72e-08733319008950
Pubmed

Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling.

DVL2 DVL3 DVL1

2.72e-08733317005174
Pubmed

Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.

DVL2 DVL3 DVL1

4.34e-08833319388021
Pubmed

Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1.

DVL2 DVL3 DVL1

4.34e-08833312165471
Pubmed

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.

DVL3 WNT3A DVL1

6.51e-08933322899650
Pubmed

RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer.

DVL2 DVL3 DVL1

6.51e-08933332965059
Pubmed

Expression of planar cell polarity genes during development of the mouse CNS.

DVL2 DVL3 DVL1

6.51e-08933316487141
Pubmed

Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract.

DVL2 DVL3 DVL1

9.30e-081033315637299
Pubmed

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin.

DVL2 WNT3A DVL1

9.30e-081033315143170
Pubmed

Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.

DVL2 DVL3 WNT3A DVL1

1.16e-074733433141892
Pubmed

Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.

DVL2 DVL3 WNT3A DVL1

1.16e-074733418351675
Pubmed

Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription.

DVL2 DVL3 DVL1

1.28e-071133310644691
Pubmed

Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.

DVL2 DVL3 DVL1

1.70e-071233312421720
Pubmed

Microtubules enable the planar cell polarity of airway cilia.

DVL2 DVL3 DVL1

1.70e-071233323122850
Pubmed

Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region.

DVL2 DVL3 DVL1

2.81e-071433312433684
Pubmed

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease.

DVL2 DVL3 WNT3A DVL1

4.10e-076433424431302
Pubmed

The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled.

DVL2 DVL3 DVL1

4.32e-071633322771245
Pubmed

Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled protein.

DVL2 DVL3 DVL1

5.24e-071733320970343
Pubmed

GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation.

DVL2 DVL3 DVL1

6.29e-071833325073924
Pubmed

Serine- and arginine-rich proteins 55 and 75 (SRp55 and SRp75) induce production of HIV-1 vpr mRNA by inhibiting the 5'-splice site of exon 3.

SRSF4 SRSF6

8.73e-07233220685659
Pubmed

Genetic analysis of disheveled 2 and disheveled 3 in human neural tube defects.

DVL2 DVL3

8.73e-07233222892949
Pubmed

The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice.

CNTNAP3 CNTNAP3B

8.73e-07233231150793
Pubmed

Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling.

INHBA WNT3A

8.73e-07233218719101
Pubmed

A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer.

SRSF4 SRSF6

8.73e-0723327651409
Pubmed

Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation.

DVL2 WNT3A

8.73e-07233232601235
Pubmed

Wnt-3a-dependent cell motility involves RhoA activation and is specifically regulated by dishevelled-2.

DVL2 WNT3A

8.73e-07233215509575
Pubmed

Wnt-mediated relocalization of dishevelled proteins.

DVL2 DVL1

8.73e-0723328856345
Pubmed

Planar polarization of node cells determines the rotational axis of node cilia.

DVL2 DVL3

8.73e-07233220098415
Pubmed

cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas.

DVL3 DVL1

8.73e-0723329344861
Pubmed

Dvl3 translocates IPMK to the cell membrane in response to Wnt.

DVL3 WNT3A

8.73e-07233222940627
Pubmed

Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.

DVL1P1 DVL1

8.73e-0723328644734
Pubmed

Disheveled proteins promote cell growth and tumorigenicity in ALK-positive anaplastic large cell lymphoma.

DVL2 DVL3

8.73e-07233223022960
Pubmed

Rac1b recruits Dishevelled and β-catenin to Wnt target gene promoters independent of Wnt3A stimulation.

DVL3 WNT3A

8.73e-07233221667018
Pubmed

Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task.

CNTNAP3 CNTNAP3B

8.73e-07233226807827
Pubmed

DVL3 Alleles Resulting in a -1 Frameshift of the Last Exon Mediate Autosomal-Dominant Robinow Syndrome.

DVL3 DVL1

8.73e-07233226924530
Pubmed

DVL1 and DVL3 require nuclear localisation to regulate proliferation in human myoblasts.

DVL3 DVL1

8.73e-07233235589804
Pubmed

Expression of dishevelled gene in Hirschsprung's disease.

DVL3 DVL1

8.73e-07233224040443
Pubmed

FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.

CNTNAP3 CNTNAP3B RYR1

1.18e-062233326494785
Pubmed

Atmin mediates kidney morphogenesis by modulating Wnt signaling.

DVL2 DVL3 DVL1

1.55e-062433324852369
Pubmed

Regulation of planar cell polarity by Smurf ubiquitin ligases.

DVL2 DVL3 DVL1

1.76e-062533319379695
Pubmed

Wnt-dependent assembly of supermolecular Dishevelled-3-based complexes.

DVL3 WNT3A

2.62e-06333220940260
Pubmed

TLR4 induced Wnt3a-Dvl3 restrains the intensity of inflammation and protects against endotoxin-driven organ failure through GSK3β/β-catenin signaling.

DVL3 WNT3A

2.62e-06333231884387
Pubmed

Dishevelled stability is positively regulated by PKCζ-mediated phosphorylation induced by Wnt agonists.

DVL2 DVL3

2.62e-06333228366812
Pubmed

Mechanism of activation of the Formin protein Daam1.

DVL2 DVL1

2.62e-06333218162551
Pubmed

Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.

CACNA1A RYR1

2.62e-06333218313230
Pubmed

Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways.

DVL2 DVL1

2.62e-06333215852005
Pubmed

Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation.

DVL3 DVL1

2.62e-06333215748172
Pubmed

Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation.

DVL3 WNT3A

2.62e-06333216501258
Pubmed

Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway.

DVL2 DVL1

2.62e-06333216116426
Pubmed

The DIX domain targets dishevelled to actin stress fibres and vesicular membranes.

DVL2 DVL1P1

2.62e-06333212384700
Pubmed

Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells.

DVL2 DVL1

2.62e-06333220224554
Pubmed

Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma.

DVL2 DVL3

2.62e-06333219137009
Pubmed

beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.

DVL2 DVL1

2.62e-06333211742073
Pubmed

Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS.

DVL3 DVL1

2.62e-06333226359454
Pubmed

Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling.

DVL2 WNT3A

2.62e-06333223396967
Pubmed

Atypical protein kinase Cι is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated dishevelled 2.

DVL2 WNT3A

2.62e-06333223396968
Pubmed

Autosomal Dominant Robinow Syndrome

DVL3 DVL1

2.62e-06333225577943
Pubmed

Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.

DVL2 DVL3 DVL1

3.10e-063033324302887
Pubmed

Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis.

DVL2 DVL3 DVL1

3.79e-063233323177622
Pubmed

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

FXR1 SRSF4 SRSF6 LARP4 PRRC2A

4.33e-0625833537794589
Pubmed

SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP.

DVL2 DVL3 DVL1

4.99e-063533339366759
Pubmed

Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea.

DVL2 DVL3 DVL1

4.99e-063533332907846
Pubmed

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein.

DVL3 DVL1

5.23e-06433211113207
Pubmed

Dynamic recruitment of axin by Dishevelled protein assemblies.

DVL2 WNT3A

5.23e-06433217606995
InteractionTOP3B interactions

DVL2 AMBRA1 MARVELD3 FXR1 LARP4 MORN1 PRRC2A RYR1 ZBTB4 NAGLU DVL1

1.29e-0514703311int:TOP3B
InteractionKLHL12 interactions

DVL2 DVL3 ZBTB4 DVL1

2.44e-05104334int:KLHL12
InteractionZNRF3 interactions

DVL2 USP42 DVL1

2.53e-0535333int:ZNRF3
InteractionDVL1P1 interactions

DVL2 DVL1P1

2.59e-055332int:DVL1P1
InteractionJAG2 interactions

CNTNAP3 CACNA1A WNT3A GJD3

3.04e-05110334int:JAG2
InteractionNXN interactions

DVL2 DVL3 DVL1

3.25e-0538333int:NXN
InteractionRASSF9 interactions

DVL2 DVL3 DVL1

3.51e-0539333int:RASSF9
InteractionCFC1 interactions

CNTNAP3 CNTNAP3B GDF15 NAGLU

5.18e-05126334int:CFC1
InteractionRNF43 interactions

DVL2 DVL3 LARP4 USP42 PDZD4 DVL1

5.96e-05427336int:RNF43
InteractionHOMER3 interactions

DVL3 FXR1 RYR1 ZBTB4

7.81e-05140334int:HOMER3
InteractionPRG2 interactions

CNTNAP3 DVL2 CNTNAP3B GDF15 NAGLU

9.37e-05285335int:PRG2
InteractionTRGV3 interactions

CNTNAP3 CNTNAP3B NAGLU

9.90e-0555333int:TRGV3
InteractionPPM1A interactions

DVL2 DVL3 CACNA1A DVL1

1.41e-04163334int:PPM1A
InteractionRASSF10 interactions

DVL2 DVL3 DVL1

1.42e-0462333int:RASSF10
InteractionAXIN1 interactions

DVL2 DVL3 FXR1 DVL1

1.51e-04166334int:AXIN1
InteractionSDF2L1 interactions

CNTNAP3 CNTNAP3B AMBRA1 WNT3A NAGLU

1.66e-04322335int:SDF2L1
InteractionCACNA1S interactions

DVL2 RYR1

2.01e-0413332int:CACNA1S
InteractionVANGL2 interactions

DVL2 DVL3 GJD3 DVL1

2.28e-04185334int:VANGL2
InteractionZSCAN25 interactions

DVL3 SRSF4 SRSF6

2.30e-0473333int:ZSCAN25
InteractionATN1 interactions

DVL2 FXR1 PRRC2A DVL1

2.38e-04187334int:ATN1
InteractionDVL2 interactions

DVL2 DVL3 AMBRA1 DVL1P1 TCEAL4 DVL1

2.54e-04557336int:DVL2
InteractionZNF821 interactions

DVL3 FXR1

2.69e-0415332int:ZNF821
InteractionINHA interactions

DVL2 INHBA

3.08e-0416332int:INHA
InteractionSORBS3 interactions

DVL2 DVL3 FXR1 TSGA10IP

3.19e-04202334int:SORBS3
InteractionKCNQ2 interactions

DVL2 DVL3 DVL1

3.48e-0484333int:KCNQ2
Cytoband1q42.13

RNF187 SNAP47

5.77e-04493321q42.13
CytobandEnsembl 112 genes in cytogenetic band chr1q42

RNF187 SNAP47 WNT3A

6.86e-04240333chr1q42
Cytoband17p13.1

DVL2 ZBTB4

3.28e-0311833217p13.1
GeneFamilyDishevelled segment polarity proteins|PDZ domain containing

DVL2 DVL3 DVL1

3.93e-094193505
GeneFamilyPDZ domain containing

DVL2 DVL3 PDZD4 DVL1

1.69e-051521941220
GeneFamilyRNA binding motif containing|Serine and arginine rich splicing factors

SRSF4 SRSF6

6.86e-0512192737
GeneFamilyRNA binding motif containing

SRSF4 SRSF6

2.07e-02213192725
GeneFamilyEndogenous ligands

INHBA WNT3A

2.53e-02237192542
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A USP42 RYR1 DVL1

8.10e-06174334ff13a5c55d18b951315908f33cb47c7f9cb901bf
ToppCellMS-Multiple_Sclerosis-Lymphocyte-T/NK-ILC|Multiple_Sclerosis / Disease, condition lineage and cell class

CACNA1A POLR3D MORN1 CCDC61

1.40e-05200334ab9bdc9365cbdffe4ed246ce0c8a008a390e387e
Drug4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide

DVL2 WNT3A

5.74e-063322ctd:C493177
DiseaseRobinow Syndrome

DVL3 DVL1

6.83e-064322C0265205
DiseaseRobinow Syndrome, Autosomal Dominant

DVL3 DVL1

6.83e-064322C4551476
DiseaseDiGeorge syndrome (is_implicated_in)

DVL1P1 DVL1

1.14e-055322DOID:11198 (is_implicated_in)
Diseaseneurodegenerative disease (implicated_via_orthology)

DVL2 DVL3 DVL1P1 DVL1

1.81e-05145324DOID:1289 (implicated_via_orthology)
Diseaseautosomal recessive intellectual developmental disorder (implicated_via_orthology)

CNTNAP3 CNTNAP3B

3.18e-058322DOID:0060308 (implicated_via_orthology)
Diseasecolon adenocarcinoma (is_marker_for)

SRSF4 SRSF6

3.37e-0425322DOID:234 (is_marker_for)
Diseasemigraine disorder

CACNA1A AMBRA1 INHBA ZBTB4

5.80e-04357324MONDO_0005277
Diseaseclear cell renal cell carcinoma (is_marker_for)

SRSF4 SRSF6

5.89e-0433322DOID:4467 (is_marker_for)
Diseaseautism spectrum disorder (implicated_via_orthology)

CNTNAP3 CNTNAP3B FXR1

5.96e-04152323DOID:0060041 (implicated_via_orthology)
Diseasemyocardial infarction (biomarker_via_orthology)

DVL1P1 INHBA DVL1

6.91e-04160323DOID:5844 (biomarker_via_orthology)
Diseaselung carcinoma, estrogen-receptor negative breast cancer, ovarian endometrioid carcinoma, colorectal cancer, prostate carcinoma, ovarian serous carcinoma, breast carcinoma, ovarian carcinoma, lung adenocarcinoma, squamous cell lung carcinoma

DVL1P1 DVL1

1.46e-0352322EFO_0000305, EFO_0000571, EFO_0000708, EFO_0001071, EFO_0001075, EFO_0001663, EFO_1000650, EFO_1001515, EFO_1001516, MONDO_0005575

Protein segments in the cluster

PeptideGeneStartEntry
RRHRAHRRPGEEGPE

CACNA1A

956

O00555
LGHRVAGRRGQDCRR

CCDC61

236

Q9Y6R9
GHLCRNGGRCREKRR

CNTNAP3

966

Q9BZ76
DNGDRSRHRAPRNAR

AMBRA1

781

Q9C0C7
AQRERPRRRDGPEHA

DVL3

141

Q92997
RERPRRRDSSEHGAG

DVL2

161

O14641
GEACRGHNRSPLVRR

NAGLU

506

P54802
EDHPHRRRRRGLECD

INHBA

301

P08476
GVRCKRGEERDRRPC

KIRREL3-AS3

11

Q8N7Y1
RDRRQGHGVLRCADG

MORN1

161

Q5T089
DSRHQRDSRRRPGGR

FXR1

431

P51114
AGRRQHAEERGRRNP

PDZD4

536

Q76G19
GRRRARARNGDHCPL

GDF15

191

Q99988
GRPRAGERDNRCNRA

GJD3

216

Q8N144
GRRRREDDRISRPHP

LARP4

451

Q71RC2
RERDPDRGPRRDTHR

MARVELD3

81

Q96A59
AARTNGHPRGDRRRD

DVL1

156

O14640
AARTNGHPRGDRRRD

DVL1P1

156

P54792
ARDGPGIRRDRRREH

RYR1

2391

P21817
GIRRDRRREHFGEEP

RYR1

2396

P21817
GHLCRNGGRCREKRR

CNTNAP3B

966

Q96NU0
AEEGEHRTPCRRRAG

TSGA10IP

256

Q3SY00
KRERDRDRQREGHGR

POLR3D

81

P05423
CGERVIVEHARGPRR

SRSF4

61

Q08170
RGLHCAGAERPRRRG

SNAP47

6

Q5SQN1
EGARARGPRGCRDRD

TMEM80

51

Q96HE8
QRAPREPVRADCGHR

RNF187

16

Q5TA31
NVGMEDGERPRRRRH

PRRC2A

1231

P48634
DGERPRRRRHGRAQQ

PRRC2A

1236

P48634
CGERVIVEHARGPRR

SRSF6

61

Q13247
REFRGGCRAPRRDIE

TCEAL4

196

Q96EI5
HNRGRRGCEPARERE

USP42

1096

Q9H9J4
RGCEPARERERHRPS

USP42

1101

Q9H9J4
PAGRARTERRHRCGD

ZBTB4

716

Q9P1Z0
CCGRGHNARAERRRE

WNT3A

311

P56704
RQGQSRRRKGPHCER

VPS72

151

Q15906