Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	DUF3523	ATAD3B ATAD3C	4.76e-05	3	75	2	PF12037
Domain	DUF3523	ATAD3B ATAD3C	4.76e-05	3	75	2	IPR021911
Domain	Prostanoid_rcpt	TBXA2R PTGER1	4.39e-04	8	75	2	IPR008365
Domain	Nuclear_transport_factor_2_euk	G3BP1 G3BP2	4.39e-04	8	75	2	IPR018222
Domain	NTF2	G3BP1 G3BP2	4.39e-04	8	75	2	PF02136
Domain	NTF2_DOMAIN	G3BP1 G3BP2	5.62e-04	9	75	2	PS50177
Domain	NTF2	G3BP1 G3BP2	5.62e-04	9	75	2	IPR002075
Pathway	WP_GPCRS_SMALL_LIGAND	TBXA2R MTNR1A PTGER1	4.90e-05	18	57	3	MM15858
Pathway	WP_SMALL_LIGAND_GPCRS	TBXA2R MTNR1A PTGER1	5.80e-05	19	57	3	M39728
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FZD7 HEG1 ITPRIPL2 PKD1 WDR90 JADE1 ARID1A CIT SYNE4 ARHGAP33 KCNH3 TJP3	4.12e-06	1105	75	12	35748872
Pubmed	von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity.	KAT5 JADE1	4.59e-06	2	75	2	15502158
Pubmed	Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection.	G3BP1 G3BP2	4.59e-06	2	75	2	23087212
Pubmed	How segmental duplications shape our genome: recent evolution of ABCC6 and PKD1 Mendelian disease genes.	PKD1 ABCC6	4.59e-06	2	75	2	18791038
Pubmed	Mammalian class theta GST and differential susceptibility to carcinogens: a review.	GSTT2 GSTT2B	4.59e-06	2	75	2	11018744
Pubmed	Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1.	GSTT2 GSTT2B	4.59e-06	2	75	2	8617493
Pubmed	Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery.	G3BP1 G3BP2	4.59e-06	2	75	2	31199850
Pubmed	Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication.	G3BP1 G3BP2	4.59e-06	2	75	2	25653451
Pubmed	Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22.	GSTT2 GSTT2B	4.59e-06	2	75	2	7789971
Pubmed	Gene structure, expression and chromosomal localization of murine theta class glutathione transferase mGSTT1-1.	GSTT2 GSTT2B	4.59e-06	2	75	2	9854036
Pubmed	Differential effect of SARS-CoV-2 infection on stress granule formation in Vero and Calu-3 cells.	G3BP1 G3BP2	4.59e-06	2	75	2	36081788
Pubmed	Identification and characterization of GSTT3, a third murine Theta class glutathione transferase.	GSTT2 GSTT2B	4.59e-06	2	75	2	12038961
Pubmed	Molecular determinants for regulation of G3BP1/2 phase separation by the SARS-CoV-2 nucleocapsid protein.	G3BP1 G3BP2	4.59e-06	2	75	2	34400613
Pubmed	Linkage disequilibrium between two high-frequency deletion polymorphisms: implications for association studies involving the glutathione-S transferase (GST) genes.	GSTT2 GSTT2B	4.59e-06	2	75	2	19424424
Pubmed	Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation.	G3BP1 G3BP2	4.59e-06	2	75	2	34517025
Pubmed	G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.	G3BP1 G3BP2	4.59e-06	2	75	2	33497611
Pubmed	Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate.	GSTT2 GSTT2B	4.59e-06	2	75	2	1417752
Pubmed	Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network.	ATAD3B ATAD3C G3BP1 G3BP2	4.99e-06	52	75	4	26265008
Pubmed	ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.	NDUFA13 ACSL6 AHI1 G3BP1 G3BP2 CIT	5.14e-06	202	75	6	33601422
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	NDUFA13 ACSL6 ATAD3B ATAD3C G3BP1 CAMKV G3BP2 RBP3 NCKIPSD ARID1A CIT SLC25A23 TP53BP2	1.08e-05	1431	75	13	37142655
Pubmed	ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.	ATAD3B ATAD3C	1.37e-05	3	75	2	28549128
Pubmed	ATAD3 is a limiting factor in mitochondrial biogenesis and adipogenesis of white adipocyte-like 3T3-L1 cells.	ATAD3B ATAD3C	1.37e-05	3	75	2	38923254
Pubmed	Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1.	PKD1 JADE1	1.37e-05	3	75	2	23001567
Pubmed	The G3BP1-Family-USP10 Deubiquitinase Complex Rescues Ubiquitinated 40S Subunits of Ribosomes Stalled in Translation from Lysosomal Degradation.	G3BP1 G3BP2	1.37e-05	3	75	2	31981475
Pubmed	ATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly.	ATAD3B ATAD3C	1.37e-05	3	75	2	34936866
Pubmed	Mitochondria-associated membrane formation in hormone-stimulated Leydig cell steroidogenesis: role of ATAD3.	ATAD3B ATAD3C	1.37e-05	3	75	2	25375035
Pubmed	Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell.	KAT5 DNMT1	1.37e-05	3	75	2	29268763
Pubmed	[ATAD3, a vital membrane-bound mitochondrial ATPase involved in tumor progression].	ATAD3B ATAD3C	1.37e-05	3	75	2	22192748
Pubmed	RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation.	G3BP1 G3BP2	1.37e-05	3	75	2	32302572
Pubmed	G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules.	G3BP1 G3BP2	1.37e-05	3	75	2	32302571
Pubmed	The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human.	GSTT2 GSTT2B	1.37e-05	3	75	2	8761485
Pubmed	SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production.	G3BP1 G3BP2	1.37e-05	3	75	2	33495715
Pubmed	RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis.	KAT5 DNMT1	1.37e-05	3	75	2	23995786
Pubmed	Contribution of DNMT1 to Neuropathic Pain Genesis Partially through Epigenetically Repressing Kcna2 in Primary Afferent Neurons.	KCNA2 DNMT1	1.37e-05	3	75	2	31182635
Pubmed	Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE-/- mice.	LPA ACE	1.37e-05	3	75	2	17135368
Pubmed	Hair follicle stem cells provide a functional niche for melanocyte stem cells.	COL17A1 DCT	1.37e-05	3	75	2	21295274
Pubmed	Glutathione S-transferases promote proinflammatory astrocyte-microglia communication during brain inflammation.	GSTT2 GSTT2B	1.37e-05	3	75	2	30783009
Pubmed	Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis.	ATAD3B ATAD3C	2.75e-05	4	75	2	36736924
Pubmed	Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP).	G3BP1 G3BP2	2.75e-05	4	75	2	17297477
Pubmed	The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy.	ATAD3B ATAD3C	2.75e-05	4	75	2	38250153
Pubmed	Both G3BP1 and G3BP2 contribute to stress granule formation.	G3BP1 G3BP2	2.75e-05	4	75	2	23279204
Pubmed	UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity.	KAT5 DNMT1	2.75e-05	4	75	2	19800870
Pubmed	Involvement of cyclooxygenase-2 and EP3 prostaglandin receptor in acute herpetic but not postherpetic pain in mice.	TBXA2R PTGER1	2.75e-05	4	75	2	15925391
Pubmed	A Mathematical Model of the Liver Circadian Clock Linking Feeding and Fasting Cycles to Clock Function.	NAMPT CRY1	2.75e-05	4	75	2	27760313
Pubmed	Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP.	EPHB2 ARHGAP33	2.75e-05	4	75	2	16777849
Pubmed	ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.	ATAD3B ATAD3C	2.75e-05	4	75	2	35236834
Pubmed	Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells.	ATAD3B ATAD3C	2.75e-05	4	75	2	29242539
Pubmed	Identification, characterization, and crystal structure of the Omega class glutathione transferases.	GSTT2 GSTT2B	2.75e-05	4	75	2	10783391
Pubmed	Micropuncture analysis of tubuloglomerular feedback regulation in transgenic mice.	TBXA2R ACE	2.75e-05	4	75	2	10589702
Pubmed	SARS-CoV-2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid droplets.	NAMPT G3BP1 G3BP2	3.75e-05	30	75	3	34780058
Pubmed	Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex.	GSTT2 GSTT2B	4.57e-05	5	75	2	9729470
Pubmed	ATAD3 controls mitochondrial cristae structure in mouse muscle, influencing mtDNA replication and cholesterol levels.	ATAD3B ATAD3C	4.57e-05	5	75	2	29898916
Pubmed	Expression analysis of ATAD3 isoforms in rodent and human cell lines and tissues.	ATAD3B ATAD3C	4.57e-05	5	75	2	24239551
Pubmed	Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation.	KAT5 DNMT1	4.57e-05	5	75	2	36417913
Pubmed	The smallest near-infrared fluorescence complementation system for imaging protein-protein and RNA-protein interactions.	G3BP1 G3BP2	4.57e-05	5	75	2	35211278
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	FZD7 ACSL6 FREM2 ARHGAP33 TP53BP2 CRY1	5.44e-05	307	75	6	37499664
Pubmed	G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP10.	G3BP1 G3BP2	6.84e-05	6	75	2	31501480
Pubmed	DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination.	KAT5 DNMT1	6.84e-05	6	75	2	21045206
Pubmed	Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation.	ATAD3B ATAD3C	6.84e-05	6	75	2	31472450
Pubmed	ATM mediates pRB function to control DNMT1 protein stability and DNA methylation.	KAT5 DNMT1	6.84e-05	6	75	2	23754744
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	MRPL23 ATAD3B RNF123 HECTD3 G3BP2 SLC25A34 ARID1A ABCC6	7.03e-05	638	75	8	31182584
Pubmed	Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.	NDUFA13 G3BP1 PSMA1 G3BP2	8.08e-05	105	75	4	22505724
Pubmed	Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis.	NAMPT CRY1	9.57e-05	7	75	2	19299583
Pubmed	A common variant in DRD3 gene is associated with risperidone-induced extrapyramidal symptoms.	MAOB ACE	9.57e-05	7	75	2	19506579
Pubmed	Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization.	G3BP1 G3BP2	9.57e-05	7	75	2	32302570
Pubmed	Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth.	TBXA2R PTGER1	9.57e-05	7	75	2	26018088
Pubmed	A 3D structural SARS-CoV-2-human interactome to explore genetic and drug perturbations.	G3BP1 G3BP2	9.57e-05	7	75	2	34845387
Pubmed	ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.	ATAD3B ATAD3C	1.27e-04	8	75	2	30914652
Pubmed	Prostanoid receptors: structures, properties, and functions.	TBXA2R PTGER1	1.27e-04	8	75	2	10508233
Pubmed	Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis.	TBXA2R PTGER1	1.27e-04	8	75	2	20566843
Pubmed	An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse.	TASOR DNMT1	1.27e-04	8	75	2	15890782
Pubmed	Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia.	TBXA2R PTGER1	1.27e-04	8	75	2	15834430
Pubmed	Atad3 function is essential for early post-implantation development in the mouse.	ATAD3B ATAD3C	1.27e-04	8	75	2	23372768
Pubmed	The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut.	TBXA2R PTGER1	1.27e-04	8	75	2	11927615
Pubmed	Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma.	TBXA2R PTGER1	1.27e-04	8	75	2	17496729
Pubmed	Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor.	RNF123 PKD1	1.27e-04	8	75	2	25907116
Pubmed	Prostaglandin F(2alpha) receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta.	TBXA2R PTGER1	1.27e-04	8	75	2	19966781
Pubmed	The Metabolic Reprogramming of Frem2 Mutant Mice Embryos in Cryptophthalmos Development.	FREM2 ABCC6	1.64e-04	9	75	2	33490088
Pubmed	Prostaglandin E2-prostaglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression.	TBXA2R PTGER1	1.64e-04	9	75	2	21460251
Pubmed	Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.	TBXA2R PTGER1	1.64e-04	9	75	2	11782353
Pubmed	Genes to diseases (G2D) computational method to identify asthma candidate genes.	LPA ADGRA1	2.04e-04	10	75	2	18682798
Pubmed	UBAP2L arginine methylation by PRMT1 modulates stress granule assembly.	G3BP1 G3BP2	2.04e-04	10	75	2	31114027
Pubmed	Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate.	KCNA2 KCNH3	2.04e-04	10	75	2	26503718
Pubmed	A COFRADIC protocol to study protein ubiquitination.	NDUFA13 G3BP1 PSMA1 G3BP2	2.07e-04	134	75	4	24816145
Pubmed	Global identification of modular cullin-RING ligase substrates.	NDUFA13 G3BP1 PSMA1 G3BP2	2.07e-04	134	75	4	21963094
Pubmed	Deletion of ATAD3A inhibits osteogenesis by impairing mitochondria structure and function in pre-osteoblast.	ATAD3B ATAD3C	2.49e-04	11	75	2	36000457
Pubmed	Fine genetic and comparative mapping of the deafness mutation Ames waltzer on mouse chromosome 10.	GSTT2 GSTT2B	2.49e-04	11	75	2	9653653
Pubmed	SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA.	G3BP1 G3BP2	2.49e-04	11	75	2	34634033
Pubmed	G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA.	G3BP1 G3BP2	2.49e-04	11	75	2	24992036
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	ATAD3B ATAD3C CAMKV ARID1A	2.95e-04	147	75	4	16959763
Pubmed	G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.	G3BP1 G3BP2	2.99e-04	12	75	2	27022092
Pubmed	Extra-embryonic-specific imprinted expression is restricted to defined lineages in the post-implantation embryo.	LPA DNMT1	3.52e-04	13	75	2	21354127
Pubmed	Systematic and quantitative assessment of the ubiquitin-modified proteome.	NDUFA13 G3BP1 PSMA1 G3BP2	3.88e-04	158	75	4	21906983
Pubmed	Identification of transcripts with enriched expression in the developing and adult pancreas.	LARGE2 PSMA1 ACE DCT POFUT2 SYNE4 TJP3	4.00e-04	624	75	7	18554416
Pubmed	PRC1 preserves epidermal tissue integrity independently of PRC2.	FREM2 COL17A1	4.11e-04	14	75	2	30567998
Pubmed	A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.	NDUFA13 G3BP1 PSMA1 G3BP2	4.26e-04	162	75	4	21890473
Pubmed	Molecular variation at functional genes and the history of human populations--data on candidate genes for cardiovascular risk in the Mediterranean.	LPA ACE	4.73e-04	15	75	2	14746139
Pubmed	Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control.	KAT5 ARID1A	4.73e-04	15	75	2	17255939
Pubmed	Proteomic analysis of the mouse liver mitochondrial inner membrane.	NDUFA13 ATAD3B ATAD3C MAOB	5.70e-04	175	75	4	12865426
Pubmed	Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.	NDUFA13 G3BP1 PSMA1 G3BP2	6.33e-04	180	75	4	21139048
Cytoband	22q11.23	GSTT2 SGSM1 GSTT2B	9.25e-05	53	75	3	22q11.23
GeneFamily	Prostaglandin (prostanoid) receptors	TBXA2R PTGER1	2.77e-04	9	51	2	207
Coexpression	GSE14308_TH2_VS_TH17_DN	TBXA2R PITHD1 HEG1 AHI1 PKD1 SLC25A23 ABCC6	1.68e-06	199	75	7	M3363
ToppCell	368C-Epithelial_cells-Epithelial-B_(AT2)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	ATAD3C WDR90 CIT SLC25A23 SYNE4 TJP3	5.47e-07	177	75	6	ac8f774596068e66c0a9ea8a318be0ce5f5df834
ToppCell	368C-Epithelial_cells-Epithelial-B_(AT2)\|368C / Donor, Lineage, Cell class and subclass (all cells)	ATAD3C WDR90 CIT SLC25A23 SYNE4 TJP3	5.47e-07	177	75	6	d9c4a93b0e04a13bf39992dd1c1ec8df2c5f89fe
ToppCell	COVID-19_Mild-PLT_0\|COVID-19_Mild / Disease Group and Platelet Clusters	KCNA2 MAOB NCKIPSD SLC5A7 ARHGAP33	8.76e-06	165	75	5	083a14d3b0162cee4e79f7398b8fb739582b39ff
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_4\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	FREM2 MMP28 CACHD1 PTGER1 ABCC6	1.13e-05	174	75	5	110369f6b78de34a6d934b5b47cecd023347bc80
ToppCell	Adult-Epithelial-basal_cell\|Adult / Lineage, Cell type, age group and donor	COL17A1 HYKK LPA SLC5A7 CACHD1	1.44e-05	183	75	5	00a6b19ca49e3b8e0d1cd387a3515b0ff4b81c81
ToppCell	Basal\|World / shred by cell class for mouse tongue	LARGE2 FREM2 HEG1 COL17A1 CACHD1	1.44e-05	183	75	5	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SLC37A1 LARGE2 AHI1 ETV5 TP53BP2	2.06e-05	197	75	5	1485933986921ff45669d9b7501c8d17050b3e97
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	FZD7 CACHD1 JADE1 ARID1A SLC25A23	2.16e-05	199	75	5	358c4b3037f59378db8916a2fbe9ed4830cf1449
Drug	Benperidol [2062-84-2]; Down 200; 10.4uM; PC3; HT_HG-U133A	TBXA2R SLC37A1 HEG1 PLEKHG6 ETV5 ACE TJP3	3.81e-06	196	75	7	4196_DN
Drug	Adrenosterone [382-45-6]; Down 200; 13.4uM; PC3; HT_HG-U133A	EPHB2 AHI1 KAT5 PLEKHG6 NCKIPSD ARID1A SLC25A23	4.21e-06	199	75	7	5045_DN
Drug	Wy17186	TBXA2R PTGER1	1.07e-05	2	75	2	CID006450316
Disease	Charcot-Marie-Tooth disease (biomarker_via_orthology)	GSTT2 GSTT2B	6.20e-06	2	74	2	DOID:10595 (biomarker_via_orthology)
Disease	neuromuscular disease (implicated_via_orthology)	ATAD3B ATAD3C	3.71e-05	4	74	2	DOID:440 (implicated_via_orthology)
Disease	blood platelet disease (is_implicated_in)	EPHB2 TBXA2R	6.17e-05	5	74	2	DOID:2218 (is_implicated_in)
Disease	multisite chronic pain	RNF123 CAMKV SDK1 CRY1	9.76e-05	95	74	4	EFO_0010100
Disease	Unilateral agenesis of kidney	GREB1L FREM2	1.72e-04	8	74	2	C0266294
Disease	Carcinoma, Granular Cell	ARID1A PTGER1 ACE DNMT1	2.11e-04	116	74	4	C0205644
Disease	Adenocarcinoma, Tubular	ARID1A PTGER1 ACE DNMT1	2.11e-04	116	74	4	C0205645
Disease	Adenocarcinoma, Oxyphilic	ARID1A PTGER1 ACE DNMT1	2.11e-04	116	74	4	C0205642
Disease	Carcinoma, Cribriform	ARID1A PTGER1 ACE DNMT1	2.11e-04	116	74	4	C0205643
Disease	Adenocarcinoma, Basal Cell	ARID1A PTGER1 ACE DNMT1	2.11e-04	116	74	4	C0205641
Disease	Adenocarcinoma	ARID1A PTGER1 ACE DNMT1	2.11e-04	116	74	4	C0001418
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	KAT5 LPA ARID1A DCT CRY1	2.54e-04	224	74	5	EFO_0004530, EFO_0008317
Disease	serum alanine aminotransferase measurement	MMP28 LTN1 ETV5 ADGRA1 XKR6 ARID1A GSTT2B DNMT1 TJP3	3.19e-04	869	74	9	EFO_0004735
Disease	very low density lipoprotein particle size measurement	KAT5 LPA ARID1A DCT	3.56e-04	133	74	4	EFO_0008594
Disease	granulocyte count	MYO1G AHI1 KCNA2 XKR6 DNMT1	4.51e-04	254	74	5	EFO_0007987
Disease	3-formylindole measurement	GSTT2 GSTT2B	4.75e-04	13	74	2	EFO_0801025
Disease	leukemia (is_implicated_in)	ACSL6 ACE	4.75e-04	13	74	2	DOID:1240 (is_implicated_in)
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	PKD1 ACE	7.28e-04	16	74	2	DOID:0110861 (implicated_via_orthology)
Disease	syndrome (implicated_via_orthology)	ATAD3B ATAD3C	9.25e-04	18	74	2	DOID:225 (implicated_via_orthology)
Disease	reticulocyte count	GREB1L MYO1G PITHD1 KAT5 MMP28 PKD1 LTN1 PAQR3 DNMT1	1.19e-03	1045	74	9	EFO_0007986
Disease	free cholesterol:total lipids ratio, intermediate density lipoprotein measurement	KAT5 LPA XKR6	1.33e-03	86	74	3	EFO_0008595, EFO_0020945
Disease	Coronary heart disease	LPA ACE	1.65e-03	24	74	2	C0010068
Disease	Depressive Symptoms	SLC5A7 ACE	1.94e-03	26	74	2	C0086132
Disease	chronic myeloid leukemia (is_marker_for)	ACE DNMT1	2.09e-03	27	74	2	DOID:8552 (is_marker_for)
Disease	Retinitis Pigmentosa	AHI1 RBP3 UBAP1L	2.30e-03	104	74	3	C0035334
Disease	longevity, healthspan, parental longevity	HYKK LPA	2.41e-03	29	74	2	EFO_0004300, EFO_0007796, EFO_0009762
Disease	neutrophil count, basophil count	MYO1G AHI1 XKR6 DNMT1	2.46e-03	224	74	4	EFO_0004833, EFO_0005090

Protein segments in the cluster

Peptide	Gene	Start	Entry
GYLPQNIPLEIIRYL	TRHDE	731	Q9UKU6
VRQYLRQYLMGPRGP	COL17A1	1096	Q9UMD9
ILYRVGDGVYLPPEA	DNMT1	931	P26358
YGDRYINLRGPIPAH	ACE	266	P12821
RDGYPIILYEIPSGR	AHI1	631	Q8N157
PYPRQPLLRFYLVSG	ADGRA1	126	Q86SQ6
RYIATPNGVLRIYPG	CACHD1	731	Q5VU97
PARAYLDIPNPRYLG	CIT	1861	O14578
EGYVPRNLLGLYPRI	TP53BP2	1106	Q13625
VVYREGPLYPVNQLR	LARGE2	491	Q8N3Y3
PVLVPRGIRLYTYEQ	PAQR3	21	Q6TCH7
LETPYYLVGRRPAGG	KCNH3	406	Q9ULD8
GGRGLATVIYPYLLP	LTN1	351	O94822
LPAVGRKPLDLYRLY	ARID1A	1041	O14497
YFPPGILTQYGRVLR	MAOB	401	P27338
YYQSGGRLRRPVNVP	KCNA2	91	P16389
YIIRYGPGHGLLQRR	FREM2	1341	Q5SZK8
LTLPPYQRRGYGKLL	KAT5	371	Q92993
YPYGRLLEPVSNQRE	CPA5	331	Q8WXQ8
YAPRQLGLTEPRIYI	EPHB2	381	P29323
LPLARVGRYELQYPG	PTGER1	171	P34995
YGPIDYKRNLPRRGL	NDUFA13	16	Q9P0J0
YREGPPYQRRGSLQL	ETV5	356	P41161
VRNPELERNGLYPAY	HEG1	1336	Q9ULI3
TQIPTQRYGRRPYGV	PSMA1	116	P25786
PVALGYELFEGRPRL	GSTT2B	176	P0CG30
VRPVILIGYGTLPYF	GREB1L	396	Q9C091
EEYEPRGPGRPLYQR	HELZ	1746	P42694
QSRYYRAPEIILGLP	HIPK3	361	Q9H422
LPLAGLYLVQGLPYG	MFSD3	6	Q96ES6
GRLYPRGYPVLDPSR	PLEKHG6	36	Q3KR16
PLLLYRAAPPAYGRG	ARHGAP33	1231	O14559
PRQLKVPPYLGYRFL	FZD7	211	O75084
LSGIIGERLPIRYYL	SLC37A1	116	P57057
YLVRLLTYLPGRPIA	HYKK	121	A2RU49
YLAPEVVGRQRYGRP	CAMKV	186	Q8NCB2
PSPLLVGREFVRQYY	G3BP1	6	Q13283
PSPLLVGREFVRQYY	G3BP2	6	Q9UN86
PVALGYELFEGRPRL	GSTT2	176	P0CG29
RTDPNGDYIRRYLPV	CRY1	421	Q16526
GDYIRRYLPVLRGFP	CRY1	426	Q16526
RRIPLYYPNAGLTRN	LPA	1421	P08519
NRGLYRHILLYGPPG	ATAD3C	166	Q5T2N8
LRGYILRYRLAGLPG	SDK1	801	Q7Z5N4
ILQGYRVVYEPLAPV	SDK1	1831	Q7Z5N4
VIYPAPRDGRLYVPT	PKD1	826	P98161
QRLPQLLRAYGGPRY	ITPRIPL2	501	Q3MIP1
LARGGLQVEPYYPRS	MMP28	441	Q9H239
RITGGEPYLYLQPLI	SLC5A7	446	Q9GZV3
RIPRTPYLVLSYVNG	SYNE4	386	Q8N205
LQGELQARGTYPRPY	SLC25A34	36	Q6PIV7
SRRRYLLYDVNPPEG	POFUT2	41	Q9Y2G5
GLRYRPELPLAVQGV	ABCC6	1271	O95255
YYGIRVKPDSPLNRL	RFX3	251	P48380
YKLLPPYLRVIQGDG	NAMPT	341	P43490
HFPLRPYYVGPIRIL	OPRPN	106	Q99935
YPYLGLGRVPAKERA	JADE1	776	Q6IE81
GYVPPAYLRRLQGLE	NCKIPSD	46	Q9NZQ3
PLGDRGYLFLLSPYQ	TASOR	461	Q9UK61
PLYDTLGPGAIRYII	ACSL6	176	Q9UKU0
NRGLYRHILLYGPPG	ATAD3B	341	Q5T9A4
VGIRYRDGPLLYELL	XKR6	621	Q5GH73
TPVGRGILRAYFDPL	TXNDC16	671	Q9P2K2
GLTGRYLYVLFRPLP	WDR90	66	Q96KV7
LPGPRYSTQRGVYLL	RBP3	526	P10745
PPEQRGLAYGLYLRI	PITHD1	21	Q9GZP4
SRPLRYPVAGYRPLQ	RNF123	251	Q5XPI4
GIRVYYSPPVARRLG	SOGA1	1011	O94964
MARNVVYPLYRLGGP	MRPL23	1	Q16540
VYPLYRLGGPQLRVF	MRPL23	6	Q16540
EQELLRLIYYGGIQP	SGSM1	606	Q2NKQ1
RLIYYGGIQPEIRKA	SGSM1	611	Q2NKQ1
YSVRDTLLGPGRPYR	DCT	191	P40126
IGPVVALGYPLRRAI	UBAP1L	276	F5GYI3
QGRYPPYERVVLREA	TJP3	601	O95049
PRAFYRGYLPNVLGI	SLC25A23	331	Q9BV35
RGYLPNVLGIIPYAG	SLC25A23	336	Q9BV35
LPLLGVGRYTVQYPG	TBXA2R	166	P21731
SRLPARIYIYPDKLG	HECTD3	796	Q5T447
PNLRAGTLQYDPRIY	MTNR1A	161	P48039
PLYGPEAIARYQGRE	MYO1G	56	B0I1T2