Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionactin binding

FKBP15 SHROOM3 INPPL1 MTSS1 TRIOBP RUSC1 FMN2 SAMD14 EPB41L1 MYBPC3

5.37e-054798910GO:0003779
DomainSAM/pointed

SASH3 INPPL1 CASKIN1 DGKD SAMD14 MAP3K6

2.44e-05117926IPR013761
DomainSAM_2

SASH3 INPPL1 DGKD SAMD14

5.87e-0543924PF07647
DomainSAM

SASH3 INPPL1 CASKIN1 DGKD SAMD14

7.38e-0588925SM00454
DomainSAM_DOMAIN

SASH3 INPPL1 CASKIN1 DGKD SAMD14

1.06e-0495925PS50105
DomainSAM

SASH3 INPPL1 CASKIN1 DGKD SAMD14

1.17e-0497925IPR001660
Domain-

SASH3 INPPL1 CASKIN1 DGKD SAMD14

1.78e-041069251.10.150.50
DomainDAGK_acc

DGKZ DGKD

1.05e-0310922PF00609
DomainDiacylglycerol_kin_accessory

DGKZ DGKD

1.05e-0310922IPR000756
DomainDAGKa

DGKZ DGKD

1.05e-0310922SM00045
DomainSSD

PTCHD3 DISP2

1.81e-0313922IPR000731
DomainSSD

PTCHD3 DISP2

1.81e-0313922PS50156
DomainDAGKc

DGKZ DGKD

2.10e-0314922SM00046
DomainDiacylglycerol_kinase_cat_dom

DGKZ DGKD

2.42e-0315922IPR001206
DomainDAGK_cat

DGKZ DGKD

2.42e-0315922PF00781
DomainDAGK

DGKZ DGKD

2.42e-0315922PS50146
DomainPost-SET_dom

SETD1A NSD2

2.75e-0316922IPR003616
DomainPostSET

SETD1A NSD2

2.75e-0316922SM00508
DomainPOST_SET

SETD1A NSD2

2.75e-0316922PS50868
DomainNAD/diacylglycerol_kinase

DGKZ DGKD

3.11e-0317922IPR016064
DomainSAM_1

INPPL1 CASKIN1 SAMD14

4.60e-0368923PF00536
DomainPDZ

SHROOM3 PARD6A TJP1 FRMPD3

5.21e-03141924PF00595
DomainPDZ

SHROOM3 PARD6A TJP1 FRMPD3

6.17e-03148924SM00228
Domain-

SHROOM3 PARD6A TJP1 FRMPD3

6.47e-031509242.30.42.10
DomainPDZ

SHROOM3 PARD6A TJP1 FRMPD3

6.62e-03151924PS50106
DomainPDZ

SHROOM3 PARD6A TJP1 FRMPD3

6.77e-03152924IPR001478
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ZFYVE28 SETD1A SHROOM3 PPP2R5C NSD2 CASKIN1 MTSS1 TMX4 FBRSL1 PLCB1 TRIOBP BCOR DAGLA ZNF687

1.48e-10529931414621295
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

SCAF1 SP3 SHROOM3 ERCC3 PPP2R5C MDN1 AFTPH BRCA1 PCNX3 NSD2 TRIOBP DGKZ AATF XPC RAB11FIP1 BCOR CEP170B EPB41L1 ZNF687 DDX10

2.22e-091497932031527615
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SCAF1 SETD1A SHROOM3 MDN1 PCNX3 NSD2 INPPL1 CASKIN1 SNX8 FBRSL1 DISP2 RIPOR1 SRCAP FBXO46 CEP170B ZNF687

3.72e-081105931635748872
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

SLC35G1 SCAF1 ZNF469 BRCA1 NSD2 FBRSL1 RCN1 FMN2 ZC3H18 XPC RAB11FIP1 SRCAP BCOR NCKAP5L CEP170B ZNF687

4.26e-081116931631753913
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

EHBP1 SHROOM3 MDN1 AFTPH TJP1 RANBP3 INPPL1 FMN2 HNRNPUL1 RAB11FIP1 NCKAP5L MAP3K6 CEP170B EPB41L1

7.10e-08861931436931259
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

SETD1A MDN1 TJP1 AATF ZC3H18 XPC HNRNPUL1 SRCAP ZNF687

1.17e-0639493927248496
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

FKBP15 ZFR2 PACS2 DISP2 RIPOR1 ARRDC3 KIF17 CEP170B EPB41L1

1.52e-0640793912693553
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

FKBP15 SHROOM3 MDN1 TJP1 CASKIN1 PLCB1 TRIOBP DGKZ FRMPD3 BCOR CEP170B EPB41L1 FBXO2

1.74e-06963931328671696
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

DMTF1 SETD1A SP3 ZNF469 SHROOM3 AFTPH RANBP3 INPPL1 ARRDC3

2.39e-0643093935044719
Pubmed

Beta-adrenergic regulation of the heart expressing the Ser1700A/Thr1704A mutated Cav1.2 channel.

CACNA1C ADRB1

7.07e-06293228778765
Pubmed

Proteosomal degradation of NSD2 by BRCA1 promotes leukemia cell differentiation.

BRCA1 NSD2

7.07e-06293232826945
Pubmed

Differentiation driven changes in the dynamic organization of Basal transcription initiation.

ERCC3 XPC

7.07e-06293219841728
Pubmed

Nuclear phospholipase C-β1 and diacylglycerol LIPASE-α in brain cortical neurons.

PLCB1 DAGLA

7.07e-06293224076015
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

SCAF1 MDN1 AFTPH PACS2 RIPOR1 ZC3H18 XPC HNRNPUL1 BCOR UBE2E3 ZNF687

7.19e-06774931115302935
Pubmed

Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.

CACNA1C IGFBP3 TJP1 FBRSL1 TRIOBP FMN2 BCOR DAGLA

7.19e-0637193815747579
Pubmed

Proteomic analysis of in vivo phosphorylated synaptic proteins.

PLCB1 FMN2 SAMD14 EPB41L1

1.27e-055393415572359
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

EHBP1 FKBP15 AFTPH TJP1 INPPL1 FBRSL1 KNDC1 DGKZ RIPOR1 AATF RAB11FIP1 NCKAP5L

2.12e-051038931226673895
Pubmed

Expression analysis of the MCPH1/BRIT1 and BRCA1 tumor suppressor genes and telomerase splice variants in epithelial ovarian cancer.

BRCA1 TERT

2.12e-05393229860064
Pubmed

BRCA1 inhibition of telomerase activity in cultured cells.

BRCA1 TERT

2.12e-05393214612409
Pubmed

Aneuploidy is associated with TP53 expression but not with BRCA1 or TERT expression in sporadic colorectal cancer.

BRCA1 TERT

2.12e-05393220032382
Pubmed

Telomere length in myelodysplastic syndromes.

CD19 TERT

2.12e-05393221635204
Pubmed

Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53.

BRCA1 AATF

2.12e-05393225996291
Pubmed

Inhibition of human telomerase reverse transcriptase gene expression by BRCA1 in human ovarian cancer cells.

BRCA1 TERT

2.12e-05393212646176
Pubmed

A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells.

CACNA1C PRKG1

2.12e-05393214597716
Pubmed

Human Telomerase Reverse Transcriptase (hTERT) Transcription Requires Sp1/Sp3 Binding to the Promoter and a Permissive Chromatin Environment.

SP3 TERT

2.12e-05393226487723
Pubmed

Regulation of telomerase activity in Jurkat T cells by transcription factors Sp1 and Sp3.

SP3 TERT

2.12e-05393212297462
Pubmed

Immunohistochemical analysis of NKX2.2, ETV4, and BCOR in a large series of genetically confirmed Ewing sarcoma family of tumors.

NKX2-2 BCOR

2.12e-05393228864350
Pubmed

Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.

FANCE ERCC3 BRCA1 XPC

3.42e-056893420496165
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

CACNA1C CASKIN1 PLCB1 FMN2 SAMD14 CEP170B EPB41L1

4.21e-0534793717114649
Pubmed

Transactivation of repair genes by BRCA1.

BRCA1 XPC

4.23e-05493212496474
Pubmed

G-protein-activated phospholipase C-beta, new partners for cell polarity proteins Par3 and Par6.

PARD6A PLCB1

4.23e-05493215782111
Pubmed

DGKζ is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway.

DGKZ DGKD

4.23e-05493222450320
Pubmed

Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells.

SP3 TERT

4.23e-05493212151407
Pubmed

Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2.

TP53RK DDX10

4.23e-05493215380516
Pubmed

The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA.

ERCC3 XPC

4.23e-05493210734143
Pubmed

Nuclear diacylglycerol kinase-theta is activated in response to alpha-thrombin.

DGKZ DGKD

4.23e-05493211309392
Pubmed

A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer.

BRCA1 TERT

4.23e-05493211916966
Pubmed

DNA nucleotide excision repair-dependent signaling to checkpoint activation.

ERCC3 XPC

4.23e-05493217088560
Pubmed

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

MDN1 BRCA1 XPC SRCAP ZNF687

5.34e-0515093528242625
Pubmed

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.

FANCE BRCA1 NSD2 SRCAP TERT

6.64e-0515793530686591
Pubmed

Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1.

SP3 TERT

7.04e-05593217548428
Pubmed

HMGA2 is regulated by LIN28 and BRCA1 in human placental cells.

BRCA1 LIN28A

7.04e-05593230137214
Pubmed

Trichostatin A, a histone deacetylase inhibitor, activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells: alteration of the Sp1/Sp3/HDAC1 multiprotein complex.

SP3 IGFBP3

7.04e-05593212200149
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

ERCC3 MDN1 NSD2 RCN1 AATF ZC3H18 ZNF687 DDX10

9.40e-0553393830554943
Pubmed

Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.

FANCE BRCA1 XPC

9.53e-053393319714462
Pubmed

Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination.

SHROOM3 TJP1

1.05e-04693220081189
Pubmed

Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric cancer.

BRCA1 TERT

1.05e-04693220127252
Pubmed

PKCzetaII is a target for degradation through the tumour suppressor protein pVHL.

PARD6A DGKZ

1.05e-04693217350623
Pubmed

Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation.

BRCA1 XPC

1.05e-04693219805520
Pubmed

Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.

ZNF469 TJP1 HS3ST3B1

1.14e-043593323291589
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

PPP2R5C TJP1 NSD2 RCN1 TRIOBP FMN2 AATF RAB11FIP1 BCOR NCKAP5L EPB41L1

1.14e-041049931127880917
Pubmed

Association study of 182 candidate genes in anorexia nervosa.

ADRB1 IGFBP3 PPP1R1B PLIN1 EPB41L1

1.33e-0418293520468064
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

EHBP1 PARD6A INPPL1 PLCB1 TRIOBP RAB11FIP1 EPB41L1

1.40e-0442193736976175
Pubmed

Single nucleotide polymorphisms in breast cancer.

DMTF1 XPC

1.47e-04793215010895
Pubmed

CtIP-mediated resection is essential for viability and can operate independently of BRCA1.

BRCA1 CD19

1.47e-04793224842372
Pubmed

A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy.

ERCC3 XPC

1.47e-04793210447254
Pubmed

Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure.

SHROOM3 TJP1

1.47e-04793225596276
Pubmed

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

FKBP15 MDN1 NSD2 AATF ZC3H18 DDX10

1.54e-0429893632353859
Pubmed

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ZFYVE28 FBRSL1 BCOR NCKAP5L

1.60e-0410193410997877
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

EHBP1 CACNA1C SHROOM3 TJP1 NSD2 FBRSL1 KNDC1 TRIOBP RIPOR1 DAGLA UBE2E3 CEP170B EPB41L1

1.65e-041489931328611215
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

SETD1A MDN1 SRCAP EPB41L1

1.80e-041049349205841
Pubmed

Mammalian Nkx2.2+ perineurial glia are essential for motor nerve development.

TJP1 NKX2-2

1.96e-04893224979729
Pubmed

NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity.

BRCA1 CD19

1.96e-04893226443207
Pubmed

E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages.

BRCA1 UBE2E3

1.96e-04893217873885
Pubmed

Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells.

PARD6A TJP1

1.96e-04893212203721
Pubmed

Identification of PKCzetaII: an endogenous inhibitor of cell polarity.

PARD6A TJP1

1.96e-04893214685273
Pubmed

Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons.

BRCA1 DAGLA

1.96e-04893223319656
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

EHBP1 FKBP15 PPP2R5C TJP1 CASKIN1 TMX4 KNDC1 PLCB1 TRIOBP CEP170B EPB41L1

2.32e-041139931136417873
Pubmed

MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity.

ERCC3 TERT

2.52e-04993219106100
Pubmed

Xeroderma Pigmentosum

ERCC3 XPC

2.52e-04993220301571
Pubmed

GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.

PARD6A MTSS1

2.52e-04993223446420
Pubmed

Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures.

PARD6A TJP1

2.52e-04993211257119
Pubmed

BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation.

BRCA1 CD19

2.52e-04993230704900
Pubmed

Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells.

SETD1A TERT

2.52e-04993222723415
Pubmed

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.

BRCA1 CD19

2.52e-04993223657012
Pubmed

Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System.

CD19 TJP1

2.52e-04993229768210
Pubmed

Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions.

SHROOM3 TJP1

2.52e-04993217666436
Pubmed

Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.

IGFBP3 BRCA1 PCNX3 PPP1R1B

2.82e-0411793419124506
Pubmed

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.

BRCA1 FBRSL1 AATF BCOR ZNF687 DDX10

3.07e-0433993630415952
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

SETD1A RANBP3 ZC3H18 SRCAP ZNF687 DDX10

3.17e-0434193632971831
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

DMTF1 SP3 ZSCAN5C AATF HNRNPUL1 SRCAP TERT DMBX1 ZNF687

3.19e-0480893920412781
Pubmed

BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.

MDN1 TJP1 TRIOBP AATF ZC3H18

3.62e-0422693525900982
Pubmed

A Large-scale genetic association study of esophageal adenocarcinoma risk.

ERCC3 IGFBP3 BRCA1 INPPL1 XPC TERT

3.69e-0435193620453000
Pubmed

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.

BRCA1 UBE2E3

3.83e-041193210500182
Pubmed

Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome.

ERCC3 XPC

3.83e-041193211259578
Pubmed

Polymorphism in nucleotide excision repair gene XPC correlates with bleomycin-induced chromosomal aberrations.

BRCA1 XPC

3.83e-041193217685459
Pubmed

Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.

DGKZ DGKD

3.83e-041193217021016
Pubmed

The murine gene, Traube, is essential for the growth of preimplantation embryos.

TJP1 AATF

3.83e-041193211071758
Pubmed

Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain.

HS3ST3B1 HS6ST3

3.83e-041193215944372
Pubmed

Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.

DMTF1 CACNA1C

3.83e-041193220351715
Pubmed

Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination.

BRCA1 UBE2E3

3.83e-041193219712108
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

PCNX3 TJP1 MTSS1 RUSC1 RIPOR1 ZC3H18 SAMD14 NCKAP5L UBE2E3 LIN28A CEP170B

4.02e-041215931115146197
Pubmed

A role for Saccharomyces cerevisiae Centrin (Cdc31) in mitochondrial function and biogenesis.

MDN1 XPC

4.59e-041293230251372
Pubmed

An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the 'Legs at odd angles' (Loa) mutation.

PPP2R5C CEP170B

4.59e-041293211867214
Pubmed

The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes.

SHROOM3 BCOR

4.59e-041293224211586
Pubmed

Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis.

TJP1 NKX2-2

5.41e-041393226965371
Pubmed

Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia.

TJP1 MTSS1

5.41e-041393221406566
Pubmed

Brain motor and fear circuits regulate leukocytes during acute stress.

ADRB1 CD19

5.41e-041393235636458
Pubmed

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

SCAF1 MDN1 AATF ZC3H18 ZNF687

5.83e-0425193528077445
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

CASKIN1 PLCB1 DGKZ EPB41L1 FBXO2

5.83e-0425193527507650
GeneFamilySterile alpha motif domain containing

SASH3 INPPL1 CASKIN1 DGKD SAMD14

1.27e-0588625760
GeneFamilyWD repeat domain containing|Xeroderma pigmentosum complementation groups|Nucleotide excision repair

ERCC3 XPC

3.20e-0486221125
GeneFamilyEF-hand domain containing|Diacylglycerol kinases

DGKZ DGKD

5.12e-04106221178
GeneFamilyPDZ domain containing

SHROOM3 PARD6A TJP1 FRMPD3

1.83e-031526241220
GeneFamilyRing finger proteins|Fanconi anemia complementation groups|Protein phosphatase 1 regulatory subunits|BRCA1 A complex|BRCA1 B complex|BRCA1 C complex

FANCE BRCA1

2.11e-0320622548
ToppCellTCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

SCAF1 ZBTB45 ERCC3 PCNX3 RANBP3 INPPL1 PACS2 HNRNPUL1

9.77e-09200938ad2a6da0b1ae7a9212a3c91e5eec4baa7481d8dc
ToppCellTCGA-Bile_Duct-Primary_Tumor|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

SCAF1 ZBTB45 ERCC3 PCNX3 RANBP3 INPPL1 PACS2 HNRNPUL1

9.77e-092009380350e5ffd36033099b7e32a1fdd790fff99790dc
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

EHBP1 ADRB1 SASH3 INPPL1 TRIOBP SRCAP

1.44e-061689362fb2d916eb5000a637240d38e47a9b4f61f9f83f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TJP1 MTSS1 FMN2 RIPOR1 PRKG1 HS3ST3B1

2.22e-061819365bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TJP1 MTSS1 FMN2 RIPOR1 PRKG1 HS3ST3B1

2.22e-061819368e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

EHBP1 CD19 RELL2 RANBP3 INPPL1

1.13e-05140935af9efcbaeeae69fcdac4a15fa244728b65915564
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

AFTPH MTSS1 RIPOR1 DGKD RAB11FIP1

2.36e-051639356bed27d2f67a430a847da5eb47878d14b4949c45
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRB1 TMX4 DGKZ XPC LIN28A

2.97e-05171935355a27ea88410a84210f7e4298c7c4f90cf2f8a9
ToppCellmetastatic_Brain-Myeloid_cells-CD207+CD1a+_LCs|Myeloid_cells / Location, Cell class and cell subclass

TJP1 DISP2 KIF17 FBXO2 MYBPC3

3.05e-0517293538d17e769fe8eac8b57b820490d4ddd969243ee7
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INAFM2 CD19 MTSS1 HNRNPUL1 CEP170B

3.40e-0517693529cda51a99100ddd2928cadc92da40f001d7e1f4
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INAFM2 CD19 MTSS1 HNRNPUL1 CEP170B

3.40e-0517693501774a86d7d92f31a056b753f9844f923038003e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TJP1 MTSS1 FMN2 RIPOR1 HS3ST3B1

3.50e-051779354d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCellASK428-Epithelial-Secretory|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

ZFYVE28 SLC35G1 SASH3 NCKAP5L TESPA1

3.50e-0517793566074a288501c136b4e83b883db5f0d8269ee326
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TJP1 MTSS1 FMN2 RIPOR1 HS3ST3B1

3.59e-05178935edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FKBP15 SP3 ZBTB45 FBRSL1 RIPOR1

3.79e-0518093562511d76d24b836839c3dcc2bf30485ffe9401e2
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

FKBP15 SP3 ZBTB45 FBRSL1 RIPOR1

3.99e-0518293503992d0ae519795239e4f2cc8e63f33c4482de6a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TJP1 MTSS1 FMN2 RIPOR1 HS3ST3B1

4.10e-051839353c516fe5083f02bad1f464ed284010b4131a833c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TJP1 MTSS1 FMN2 RIPOR1 HS3ST3B1

4.10e-051839359c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4|TCGA-Thryoid / Sample_Type by Project: Shred V9

FANCE EHBP1 DAGLA DMBX1 CEP170B

4.21e-05184935d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TJP1 MTSS1 FMN2 RIPOR1 HS3ST3B1

4.32e-051859359197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TJP1 MTSS1 FMN2 RIPOR1 HS3ST3B1

4.32e-05185935ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TJP1 MTSS1 FMN2 RIPOR1 HS3ST3B1

4.32e-05185935b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|368C / Donor, Lineage, Cell class and subclass (all cells)

FANCE SHROOM3 TCEAL2 CEP170B ZNF687

4.54e-05187935b827d9da7032bf051756ddf88352af922eb0f87b
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|368C / Donor, Lineage, Cell class and subclass (all cells)

FANCE SHROOM3 TCEAL2 CEP170B ZNF687

4.54e-0518793561c00604dda8b36a5c3eea6554e5601aa1b884f7
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CD19 MTSS1 RIPOR1 RAB11FIP1 LIN28A

4.78e-05189935b13f315f617840eb5143a4e8a33a657c20365c21
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CD19 MTSS1 SNX8 RIPOR1 RAB11FIP1

4.78e-05189935886dceacf96e2b6750c146a381da0bf96a2bb15b
ToppCellCTRL-Lymphoid-B_cell|Lymphoid / Disease state, Lineage and Cell class

CD19 MTSS1 SNX8 RIPOR1 DGKD

4.78e-0518993514f3a8c0f4f057ad4e6839b4c3eeaf956d6dc92e
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CD19 MTSS1 SNX8 RIPOR1 RAB11FIP1

4.78e-051899355f1f4321939877374a8ee13de93f2d1390af8e2e
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CD19 MTSS1 SNX8 RIPOR1 RAB11FIP1

4.90e-0519093560bb6aaea9691d07295f61c14d1650f5041a0f9c
ToppCellMild-CD8+_T|Mild / Disease group and Cell class

ZFYVE28 ADRB1 IGFBP3 SASH3 TMX4

5.41e-05194935c3dba9ff0ab98b6a955b32d071ad7e397dcdc6e9
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CD19 MTSS1 RIPOR1 DGKD RAB11FIP1

5.54e-05195935481989d2e5bd2582da3d86b0155c4d6615317067
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CD19 MTSS1 RIPOR1 DGKD RAB11FIP1

5.54e-051959356108a27523d1b93a7fbe35cb95704a5ad9071e3c
ToppCellSepsis-Int-URO-Lymphocyte-T/NK-CD4+_CTL|Int-URO / Disease, condition lineage and cell class

PPP2R5C IGFBP3 RELL2 PLCB1 CEP170B

5.96e-05198935717735d755745439f97ba1b71785c73945dfa9c5
ToppCellTCGA-Ovary-Primary_Tumor|TCGA-Ovary / Sample_Type by Project: Shred V9

PACS2 HNRNPUL1 NCKAP5L EPB41L1

7.23e-0510693414f548be39cec604fbdae0382cbf434fa4049840
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma|TCGA-Ovary / Sample_Type by Project: Shred V9

PACS2 HNRNPUL1 NCKAP5L EPB41L1

7.23e-05106934939b80950d39cdc7149a05fdfb64c8810064cdb1
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma|TCGA-Ovary / Sample_Type by Project: Shred V9

PACS2 HNRNPUL1 NCKAP5L EPB41L1

7.23e-05106934e9e1b55f32b3d5b9eeec94a997912e5c21c1fb48
DiseaseC-glycosyltryptophan measurement

SHROOM3 DDX10

2.69e-053892EFO_0021014
DiseaseClear cell sarcoma of kidney

BCOR TERT

1.34e-046892C0334488
Diseasexeroderma pigmentosum (is_implicated_in)

ERCC3 XPC

1.34e-046892DOID:0050427 (is_implicated_in)
Diseasexeroderma pigmentosum (implicated_via_orthology)

ERCC3 XPC

1.34e-046892DOID:0050427 (implicated_via_orthology)
DiseaseSudden Cardiac Death

CACNA1C MYBPC3

2.49e-048892C0085298
DiseaseXeroderma pigmentosum

ERCC3 XPC

3.19e-049892cv:C0043346
DiseaseUterine leiomyoma, estrogen-receptor negative breast cancer

TERT DDX10

3.98e-0410892EFO_1000650, HP_0000131
Diseasebeta thalassemia (is_marker_for)

IGFBP3 TERT

4.86e-0411892DOID:12241 (is_marker_for)
DiseaseBasal cell carcinoma

ERCC3 XPC

4.86e-0411892C0007117
Diseasechronic kidney disease (implicated_via_orthology)

SHROOM3 TERT

5.82e-0412892DOID:784 (implicated_via_orthology)
Diseaselung non-small cell carcinoma (is_implicated_in)

ERCC3 BRCA1 NSD2 TERT

8.44e-04139894DOID:3908 (is_implicated_in)
Diseasemean platelet volume

PCNX3 EXOC3L4 SNX8 FBRSL1 PLCB1 RIPOR1 SRCAP BCOR TERT MYBPC3

1.00e-0310208910EFO_0004584
Diseaseapolipoprotein A 1 measurement

ADRB1 FEZ2 SNX8 FBRSL1 DGKZ RIPOR1 HNRNPUL1 PLIN1 MYBPC3

1.05e-03848899EFO_0004614
DiseaseMYELODYSPLASTIC SYNDROME

FANCE BRCA1 PLCB1

1.11e-0367893C3463824
DiseaseBenign Neoplasm

BRCA1 TERT LIN28A

1.15e-0368893C0086692
Diseaseschizophrenia (implicated_via_orthology)

SETD1A PPP1R1B PLCB1

1.15e-0368893DOID:5419 (implicated_via_orthology)
DiseaseNeoplasms

BRCA1 TERT LIN28A

1.15e-0368893C0027651
Diseasemyelodysplastic syndrome (is_marker_for)

PLCB1 TERT

1.65e-0320892DOID:0050908 (is_marker_for)
DiseaseLeukemia, Myelocytic, Acute

FANCE BRCA1 BCOR TERT

1.89e-03173894C0023467
Diseaseimpotence (biomarker_via_orthology)

IGFBP3 PRKG1

2.00e-0322892DOID:1875 (biomarker_via_orthology)
DiseaseDown syndrome (is_marker_for)

ERCC3 IGFBP3

2.00e-0322892DOID:14250 (is_marker_for)
DiseaseFanconi Anemia

FANCE BRCA1

2.58e-0325892C0015625
Diseasebasal cell carcinoma

SCAF1 FBRSL1 TERT EPB41L1

2.61e-03189894EFO_0004193
Diseaseblood chromium measurement

ADRB1 HS6ST3

2.79e-0326892EFO_0007579
DiseaseAcute monocytic leukemia

FANCE BRCA1

2.79e-0326892C0023465
DiseaseMicronuclei, Chromosome-Defective

PPP2R5C XPC

2.79e-0326892C1449861
DiseaseMicronuclei, Genotoxicant-Induced

PPP2R5C XPC

2.79e-0326892C1449862

Protein segments in the cluster

PeptideGeneStartEntry
PPSPGAASDDDDDDV

ADRB1

421

P08588
EEEAHPSPPDDGDFL

EXOC3L4

221

Q17RC7
DARAQSPSSGDEPEP

FBRSL1

26

Q9HCM7
SSPPPLDNGAEDDDD

AFTPH

11

Q6ULP2
SNPTGAEFDPEEDEP

PPP2R5C

111

Q13362
PRDTDDDEEEPDPYG

CEP170B

1301

Q9Y4F5
VLANPPGPEDQDDDD

BCOR

1616

Q6W2J9
QSSDFPEPPDALEAD

DMTF1

596

Q9Y222
DSQGEEAEPLPASPE

DISP2

1251

A7MBM2
KSNEPEDAGTRDPDP

EFCC1

346

Q9HA90
EDAGTRDPDPTPEGA

EFCC1

351

Q9HA90
EIDPNPDQSADDRPS

ARRDC3

396

Q96B67
PEPGAAPSNEEDDSD

RANBP3

526

Q9H6Z4
PDSELGERPPEDNQS

RCN1

41

Q15293
EEAPPPSEDASNGRE

ZFYVE28

611

Q9HCC9
NLADEPVPDAEPEDG

CASKIN1

961

Q8WXD9
PRPRAPESDTGDEDQ

EPB41L1

571

Q9H4G0
QSPQEPEEGPSEDDK

MDN1

4936

Q9NU22
EGAASPEEQSPEVPD

HS3ST3B1

106

Q9Y662
ASTPEDDLSGPEEDP

MAGEH1

41

Q9H213
SSDEAGDPNEAPSPD

NCKAP5L

301

Q9HCH0
SFPEDNDEPPPDDNS

PRKG1

651

Q13976
PDAGLSDDEEPPDAS

FAM89B

146

Q8N5H3
EPAAEEPASPEESSG

MAP3K6

976

O95382
DPESVGQPEEASPEE

FBXO2

6

Q9UK22
LEEEPAQGDSNPPRD

PCNX3

101

Q9H6A9
APEGSDTDPPSEAEL

PCNX3

331

Q9H6A9
DEASEGDSPAPARPE

FBXO46

331

Q6PJ61
PESEAEDQEREPPSA

MTSS1

691

O43312
DPADLSPRDTPQGED

MTSS1

716

O43312
NEVSDSPGDEPSESP

NSD2

626

O96028
PPTPLFGDDDDDDDI

FKBP15

1201

Q5T1M5
REHPGQPEDSPEAEA

PACS2

381

Q86VP3
PDTLEDPPGFEASDD

ODAD1

461

Q96M63
EEDEPDPEAPENGSL

HS6ST3

106

Q8IZP7
EPESEFRDIDNPPAE

PLIN1

411

O60240
PGPAEPDSDDDSSDL

PARD6A

271

Q9NPB6
FSDDPESDPSEDRAP

BRCA1

1571

P38398
QEGIADVPAEDDPSP

CACNA1C

301

Q13936
EPSSVPPREEDSEND

C5orf60

61

A6NFR6
NPEDEPLGPEDEDSF

CD19

441

P15391
SAPEDQPDREEDPRA

DMBX1

191

Q8NFW5
QPDREEDPRAGAEDP

DMBX1

196

Q8NFW5
APPPGFRDNSSDEDD

FRMPD3

701

Q5JV73
PSEPDPEDAEGRLAE

C19orf67

46

A6NJJ6
DDPDAAELNPFGDPD

EHBP1

271

Q8NDI1
PEESSDSEPEAEPGS

DGKD

21

Q16760
TPERPPSAAANDEEE

DAGLA

866

Q9Y4D2
PAGERDDQSPDSVPE

KNDC1

851

Q76NI1
DDDGFDPSTLPDPDK

DDX10

786

Q13206
EEDAPGNDPQEAVPS

ERCC3

26

P19447
PQAPDPEEEENRDSQ

FANCE

181

Q9HB96
NPEAGPEDRDEGATD

DGKZ

426

Q13574
SPREERSPQEETPEG

B3GNT6

36

Q6ZMB0
EPEEEAQGPDAPAAA

FMN2

381

Q9NZ56
NIPEDDSGVPTPEDA

SASH3

51

O75995
ASEQDAPLPEGDDAP

PTCHD3

61

Q3KNS1
SPDPEDDETPTQSDR

FEZ2

176

Q9UHY8
RGRSPQPPAEEDEDD

HNRNPUL1

191

Q9BUJ2
PRGPDEDEEETAAAP

INAFM2

136

P0DMQ5
PPAPGNASESEEDRS

IGFBP3

131

P17936
PSDARPEAEAADDFP

KIF17

656

Q9P2E2
DPSQEEEGAASPSDP

RUSC1

86

Q9BVN2
GEPPESPHAEDSERE

RAB11FIP1

851

Q6WKZ4
GSEPDDAQLQPPEDD

RELL2

51

Q8NC24
EADEEADPPASDLPT

SNX8

21

Q9Y5X2
REPDPPDDRDASDGE

INPPL1

121

O15357
PDDRDASDGEDEKPP

INPPL1

126

O15357
EAQLDSEDPEGPRPS

SHROOM3

1556

Q8TF72
EDDSRDASPPEPASP

SAMD14

166

Q8IZD0
PSADESPDNDKETPG

NKX2-2

106

O95096
PPPASRLDDEDGDFQ

SRCAP

276

Q6ZRS2
RPRPSTPAEEDEDDP

SETD1A

911

O15047
EEPEESEPSRGQDPL

TRIOBP

1706

Q9H2D6
NPRPSEADPEADPEE

AATF

16

Q9NY61
RASPAPDDTDDTPQE

CNK3/IPCEF1

871

G9CGD6
EERSEANDQGPPGED

TMX4

291

Q9H1E5
EDPSTDPGVEEPQAD

ZFR2

741

Q9UPR6
EGPDADPSLSAAPDD

ZBTB45

191

Q96K62
SQDFPGDESPRPDAQ

SCAF1

311

Q9H7N4
PPSPGDDEEEAAAAA

SP3

71

Q02447
DADQRDPAAPEPEEQ

UBE2E3

21

Q969T4
EQDADPGPASPRDTE

ZSCAN1

21

Q8NBB4
PDSEREPESEGEPES

TCEAL2

106

Q9H3H9
EADPGETPSEAPSEA

PLCB1

841

Q9NQ66
FASESEEDEQPPPRG

ZNF469

1066

Q96JG9
VSRPDPEPVSDNEED

TJP1

116

Q07157
EEEAPPSRSDPDGGD

ZNF687

1176

Q8N1G0
ATTPADGEEPAPEAE

TP53RK

6

Q96S44
DDAPPGATEEPAAAE

SLC35G1

21

Q2M3R5
PDPEPSSLDDVFQEG

TESPA1

41

A2RU30
EASDPSDEDSEPGPP

XPC

451

Q01831
PPPLDESERDGGSED

PPP1R1B

166

Q9UD71
EDEDNDVPGDRPPSS

RIPOR1

861

Q6ZS17
EEDREENPGLTSPEP

ZSCAN5C

226

A6NGD5
PQGSVAAPEEEDTDP

TERT

431

O14746
SPERQDGEGTEPDEE

TIPIN

31

Q9BVW5
SPERDPHSPEDEEQP

ZC3H18

6

Q86VM9
PEEAPEDAARAADEP

LIN28A

21

Q9H9Z2
RPAPDAPEDTGDSDE

MYBPC3

696

Q14896