Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncytokine binding

IL1RAPL1 IL12B IL20RA CCR1 IL23R IFNAR2

1.57e-05157686GO:0019955
GeneOntologyMolecularFunctioncytokine receptor activity

IL12B IL20RA CCR1 IL23R IFNAR2

1.99e-0597685GO:0004896
GeneOntologyMolecularFunctioninterleukin-12 receptor binding

IL12B IL23R

1.14e-045682GO:0005143
GeneOntologyMolecularFunctionimmune receptor activity

IL12B IL20RA CCR1 IL23R IFNAR2

2.48e-04165685GO:0140375
GeneOntologyMolecularFunctionnon-membrane spanning protein tyrosine kinase activity

TYK2 BTK PKDCC

5.16e-0446683GO:0004715
GeneOntologyMolecularFunctionproteoglycan binding

FN1 ITGA2 CTSK

7.00e-0451683GO:0043394
GeneOntologyMolecularFunctioncell adhesion molecule binding

KIRREL3 PTPN6 NEO1 FN1 TENM3 PTPRM TENM1 ITGA2

9.49e-04599688GO:0050839
GeneOntologyBiologicalProcesspositive regulation of interleukin-17 production

TYK2 IL12B BTK IL23R

2.27e-0629674GO:0032740
GeneOntologyBiologicalProcesspositive regulation of NK T cell activation

TYK2 IL12B IL23R

3.87e-0610673GO:0051135
GeneOntologyBiologicalProcessregulation of NK T cell activation

TYK2 IL12B IL23R

7.06e-0612673GO:0051133
GeneOntologyBiologicalProcesspositive regulation of natural killer cell proliferation

TYK2 IL12B IL23R

7.06e-0612673GO:0032819
GeneOntologyBiologicalProcesscell-cell adhesion

TYK2 IL1RAPL1 IL12B HHLA2 KIRREL3 PTPN6 NEO1 HMCN1 TENM3 PTPRM TENM1 IGSF9B ITGA2 IL23R

7.51e-0610776714GO:0098609
GeneOntologyBiologicalProcessregulation of natural killer cell proliferation

TYK2 IL12B IL23R

1.16e-0514673GO:0032817
GeneOntologyBiologicalProcessnatural killer cell proliferation

TYK2 IL12B IL23R

2.58e-0518673GO:0001787
GeneOntologyBiologicalProcessNK T cell activation

TYK2 IL12B IL23R

2.58e-0518673GO:0051132
GeneOntologyBiologicalProcessregulation of interleukin-17 production

TYK2 IL12B BTK IL23R

2.85e-0554674GO:0032660
GeneOntologyBiologicalProcessinterleukin-17 production

TYK2 IL12B BTK IL23R

3.53e-0557674GO:0032620
GeneOntologyBiologicalProcessT cell proliferation

TYK2 IL12B HHLA2 PTPN6 IL23R SOS1 IFNAR2

4.09e-05288677GO:0042098
GeneOntologyBiologicalProcesslymphocyte proliferation

TYK2 IL12B HHLA2 PTPN6 BTK IL23R SOS1 IFNAR2

4.32e-05398678GO:0046651
GeneOntologyBiologicalProcessmononuclear cell proliferation

TYK2 IL12B HHLA2 PTPN6 BTK IL23R SOS1 IFNAR2

4.97e-05406678GO:0032943
GeneOntologyBiologicalProcessheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

IL1RAPL1 HMCN1 TENM3 TENM1

5.24e-0563674GO:0007157
GeneOntologyBiologicalProcessregulation of lymphocyte proliferation

TYK2 IL12B HHLA2 PTPN6 BTK IL23R SOS1

5.41e-05301677GO:0050670
GeneOntologyBiologicalProcesspositive regulation of T-helper 17 type immune response

TYK2 IL12B IL23R

5.54e-0523673GO:2000318
GeneOntologyBiologicalProcesscellular response to cytokine stimulus

TYK2 IL12B PTPN6 ABCA1 FN1 BTK IL20RA CCR1 CTSK IL23R SOS1 IFNAR2

5.82e-059676712GO:0071345
GeneOntologyBiologicalProcessregulation of mononuclear cell proliferation

TYK2 IL12B HHLA2 PTPN6 BTK IL23R SOS1

6.00e-05306677GO:0032944
GeneOntologyBiologicalProcesscell-cell adhesion via plasma-membrane adhesion molecules

IL1RAPL1 KIRREL3 HMCN1 TENM3 PTPRM TENM1 IGSF9B

6.91e-05313677GO:0098742
GeneOntologyBiologicalProcessnegative regulation of interleukin-10 production

IL12B BTK IL23R

8.07e-0526673GO:0032693
GeneOntologyBiologicalProcessleukocyte proliferation

TYK2 IL12B HHLA2 PTPN6 BTK IL23R SOS1 IFNAR2

9.44e-05445678GO:0070661
GeneOntologyBiologicalProcessregulation of leukocyte proliferation

TYK2 IL12B HHLA2 PTPN6 BTK IL23R SOS1

9.99e-05332677GO:0070663
GeneOntologyBiologicalProcessregulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

TYK2 IL12B PTPN6 BTK C4BPA IL23R

1.15e-04235676GO:0002822
GeneOntologyBiologicalProcessregulation of T cell proliferation

TYK2 IL12B HHLA2 PTPN6 IL23R SOS1

1.17e-04236676GO:0042129
GeneOntologyBiologicalProcesspositive regulation of activated T cell proliferation

IL12B HHLA2 IL23R

1.52e-0432673GO:0042104
GeneOntologyBiologicalProcesspositive regulation of NK T cell proliferation

TYK2 IL12B

1.55e-046672GO:0051142
GeneOntologyBiologicalProcesspositive regulation of myeloid leukocyte differentiation

IL12B CD101 CCR1 IL23R

1.61e-0484674GO:0002763
GeneOntologyBiologicalProcessregulation of adaptive immune response

TYK2 IL12B PTPN6 BTK C4BPA IL23R

1.68e-04252676GO:0002819
GeneOntologyBiologicalProcessresponse to cytokine

TYK2 IL12B PTPN6 ABCA1 FN1 BTK IL20RA CCR1 CTSK IL23R SOS1 IFNAR2

1.70e-0410836712GO:0034097
GeneOntologyBiologicalProcessresponse to peptide

TYK2 IL12B PTPN6 ABCA1 FN1 BTK IL20RA CCR1 CTSK IL23R SOS1 IFNAR2

1.97e-0411006712GO:1901652
GeneOntologyBiologicalProcesspositive regulation of natural killer cell activation

TYK2 IL12B IL23R

1.99e-0435673GO:0032816
GeneOntologyBiologicalProcessregulation of NK T cell proliferation

TYK2 IL12B

2.16e-047672GO:0051140
GeneOntologyBiologicalProcesspositive regulation of lymphocyte proliferation

TYK2 IL12B HHLA2 BTK IL23R

2.29e-04170675GO:0050671
GeneOntologyBiologicalProcesspositive regulation of mononuclear cell proliferation

TYK2 IL12B HHLA2 BTK IL23R

2.49e-04173675GO:0032946
GeneOntologyBiologicalProcesspositive regulation of T-helper 17 cell lineage commitment

IL12B IL23R

2.87e-048672GO:2000330
GeneOntologyBiologicalProcesssynaptic membrane adhesion

IL1RAPL1 TENM3 IGSF9B

3.43e-0442673GO:0099560
GeneOntologyBiologicalProcesshomophilic cell adhesion via plasma membrane adhesion molecules

KIRREL3 HMCN1 TENM3 PTPRM IGSF9B

3.56e-04187675GO:0007156
GeneOntologyBiologicalProcesspositive regulation of memory T cell differentiation

IL12B IL23R

3.69e-049672GO:0043382
GeneOntologyBiologicalProcessinterleukin-12-mediated signaling pathway

TYK2 IL12B

3.69e-049672GO:0035722
GeneOntologyBiologicalProcesspositive regulation of leukocyte proliferation

TYK2 IL12B HHLA2 BTK IL23R

3.92e-04191675GO:0070665
GeneOntologyBiologicalProcesspositive regulation of osteoclast differentiation

IL12B CCR1 IL23R

3.94e-0444673GO:0045672
GeneOntologyBiologicalProcessNK T cell proliferation

TYK2 IL12B

4.60e-0410672GO:0001866
GeneOntologyBiologicalProcessregulation of leukocyte differentiation

IL12B PTPN6 CD101 BTK CCR1 IL23R SOS1

4.76e-04429677GO:1902105
GeneOntologyBiologicalProcessregulation of T-helper 17 type immune response

TYK2 IL12B IL23R

4.80e-0447673GO:2000316
GeneOntologyBiologicalProcesscytokine-mediated signaling pathway

TYK2 IL12B PTPN6 IL20RA CCR1 IL23R SOS1 IFNAR2

5.46e-04577678GO:0019221
GeneOntologyBiologicalProcesspositive regulation of cell adhesion

TYK2 IL12B HHLA2 PTPN6 FBLN2 FN1 ITGA2 IL23R

5.58e-04579678GO:0045785
GeneOntologyBiologicalProcessregulation of T-helper 17 cell lineage commitment

IL12B IL23R

5.61e-0411672GO:2000328
GeneOntologyBiologicalProcessregulation of memory T cell differentiation

IL12B IL23R

6.72e-0412672GO:0043380
GeneOntologyBiologicalProcessnegative regulation of humoral immune response mediated by circulating immunoglobulin

PTPN6 C4BPA

6.72e-0412672GO:0002924
GeneOntologyBiologicalProcessregulation of activated T cell proliferation

IL12B HHLA2 IL23R

7.22e-0454673GO:0046006
GeneOntologyBiologicalProcessregulation of receptor signaling pathway via JAK-STAT

TYK2 IL12B IL23R IFNAR2

7.34e-04125674GO:0046425
GeneOntologyBiologicalProcesspositive regulation of T cell proliferation

TYK2 IL12B HHLA2 IL23R

7.34e-04125674GO:0042102
GeneOntologyBiologicalProcesscellular response to interleukin-12

TYK2 IL12B

7.92e-0413672GO:0071349
GeneOntologyBiologicalProcessmemory T cell differentiation

IL12B IL23R

7.92e-0413672GO:0043379
GeneOntologyBiologicalProcesspositive regulation of receptor signaling pathway via JAK-STAT

TYK2 IL12B IL23R

8.90e-0458673GO:0046427
GeneOntologyBiologicalProcessimmunological memory formation process

IL12B IL23R

9.22e-0414672GO:0090715
GeneOntologyBiologicalProcesspositive regulation of T-helper 17 cell differentiation

IL12B IL23R

9.22e-0414672GO:2000321
GeneOntologyBiologicalProcessregulation of lymphocyte mediated immunity

IL12B PTPN6 BTK C4BPA IL23R

9.45e-04232675GO:0002706
GeneOntologyBiologicalProcesspositive regulation of myeloid cell differentiation

IL12B CD101 CCR1 IL23R

9.51e-04134674GO:0045639
GeneOntologyBiologicalProcessleukocyte differentiation

IL12B PTPN6 CD101 BTK CCR1 CTSK IL23R SOS1 IFNAR2

9.82e-04789679GO:0002521
GeneOntologyBiologicalProcessregulation of natural killer cell activation

TYK2 IL12B IL23R

1.03e-0361673GO:0032814
GeneOntologyBiologicalProcessactivation of Janus kinase activity

IL12B IL23R

1.06e-0315672GO:0042976
GeneOntologyBiologicalProcesspositive regulation of leukocyte differentiation

IL12B CD101 BTK CCR1 IL23R

1.14e-03242675GO:1902107
GeneOntologyBiologicalProcesspositive regulation of hemopoiesis

IL12B CD101 BTK CCR1 IL23R

1.14e-03242675GO:1903708
GeneOntologyBiologicalProcessT-helper 17 type immune response

TYK2 IL12B IL23R

1.18e-0364673GO:0072538
GeneOntologyBiologicalProcessregulation of receptor signaling pathway via STAT

TYK2 IL12B IL23R IFNAR2

1.21e-03143674GO:1904892
GeneOntologyBiologicalProcessnegative regulation of B cell mediated immunity

PTPN6 C4BPA

1.21e-0316672GO:0002713
GeneOntologyBiologicalProcesspositive regulation of granulocyte macrophage colony-stimulating factor production

IL12B IL23R

1.21e-0316672GO:0032725
GeneOntologyBiologicalProcessnegative regulation of immunoglobulin mediated immune response

PTPN6 C4BPA

1.21e-0316672GO:0002890
GeneOntologyBiologicalProcessresponse to interleukin-12

TYK2 IL12B

1.21e-0316672GO:0070671
GeneOntologyBiologicalProcessactivated T cell proliferation

IL12B HHLA2 IL23R

1.24e-0365673GO:0050798
GeneOntologyBiologicalProcesspositive regulation of receptor signaling pathway via STAT

TYK2 IL12B IL23R

1.24e-0365673GO:1904894
GeneOntologyBiologicalProcesspositive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

TYK2 IL12B BTK IL23R

1.44e-03150674GO:0002824
GeneOntologyBiologicalProcesspositive regulation of cell fate commitment

IL12B IL23R

1.54e-0318672GO:0010455
GeneOntologyBiologicalProcesspositive regulation of lymphocyte activation

TYK2 IL12B HHLA2 PTPN6 BTK IL23R

1.56e-03385676GO:0051251
GeneOntologyBiologicalProcessregulation of granulocyte macrophage colony-stimulating factor production

IL12B IL23R

1.72e-0319672GO:0032645
GeneOntologyBiologicalProcessnegative regulation of humoral immune response

PTPN6 C4BPA

1.72e-0319672GO:0002921
GeneOntologyBiologicalProcessregulation of lymphocyte differentiation

IL12B PTPN6 BTK IL23R SOS1

1.73e-03266675GO:0045619
GeneOntologyBiologicalProcesspositive regulation of adaptive immune response

TYK2 IL12B BTK IL23R

1.79e-03159674GO:0002821
GeneOntologyBiologicalProcessregulation of leukocyte activation

TYK2 IL12B HHLA2 PTPN6 FN1 BTK IL23R SOS1

1.79e-03694678GO:0002694
GeneOntologyBiologicalProcessregulation of interleukin-10 production

IL12B BTK IL23R

1.80e-0374673GO:0032653
GeneOntologyBiologicalProcessregulation of hemopoiesis

IL12B PTPN6 CD101 BTK CCR1 IL23R SOS1

1.81e-03540677GO:1903706
GeneOntologyBiologicalProcesspositive regulation of T-helper 1 type immune response

IL12B IL23R

1.90e-0320672GO:0002827
GeneOntologyBiologicalProcessinterleukin-10 production

IL12B BTK IL23R

2.02e-0377673GO:0032613
GeneOntologyBiologicalProcesspositive regulation of immune system process

TYK2 IL12B HHLA2 PTPN6 CD101 BTK CCR1 C4BPA ITGA2 IL23R SOS1

2.07e-0312426711GO:0002684
GeneOntologyBiologicalProcessgranulocyte macrophage colony-stimulating factor production

IL12B IL23R

2.10e-0321672GO:0032604
GeneOntologyBiologicalProcessterpenoid biosynthetic process

ALDH8A1 RPE65

2.10e-0321672GO:0016114
GeneOntologyBiologicalProcessimmunological memory process

IL12B IL23R

2.10e-0321672GO:0090713
GeneOntologyBiologicalProcessretinal metabolic process

ALDH8A1 RPE65

2.10e-0321672GO:0042574
GeneOntologyBiologicalProcessregulation of B cell mediated immunity

PTPN6 BTK C4BPA

2.17e-0379673GO:0002712
GeneOntologyBiologicalProcessB cell receptor signaling pathway

PTPN6 BTK SOS1

2.17e-0379673GO:0050853
GeneOntologyBiologicalProcessregulation of immunoglobulin mediated immune response

PTPN6 BTK C4BPA

2.17e-0379673GO:0002889
GeneOntologyBiologicalProcessT-helper 17 cell lineage commitment

IL12B IL23R

2.30e-0322672GO:0072540
GeneOntologyBiologicalProcessregulation of humoral immune response mediated by circulating immunoglobulin

PTPN6 C4BPA

2.30e-0322672GO:0002923
GeneOntologyCellularComponentinterleukin-23 receptor complex

TYK2 IL23R

6.05e-054672GO:0072536
GeneOntologyCellularComponentside of membrane

TYK2 IL12B HHLA2 ABCA1 NTM CCR1 ITGA2 CTSK OPCML IL23R MTSS2

9.76e-058756711GO:0098552
Domain-

IL1RAPL1 IL12B HHLA2 FLNC KIRREL3 NEO1 FN1 HMCN1 PTPRM NTM CD101 IL20RA IGSF9B VPREB3 OPCML IL23R IFNAR2

1.19e-1066367172.60.40.10
DomainIg-like_fold

IL1RAPL1 IL12B HHLA2 FLNC KIRREL3 NEO1 FN1 HMCN1 PTPRM NTM CD101 IL20RA IGSF9B VPREB3 OPCML IL23R IFNAR2

3.12e-107066717IPR013783
DomainFN3_dom

IL12B FLNC NEO1 FN1 PTPRM IL20RA IGSF9B IL23R IFNAR2

5.65e-08209679IPR003961
DomainIG_LIKE

IL1RAPL1 IL12B HHLA2 KIRREL3 NEO1 HMCN1 PTPRM NTM CD101 IGSF9B VPREB3 OPCML

1.54e-074916712PS50835
DomainIg-like_dom

IL1RAPL1 IL12B HHLA2 KIRREL3 NEO1 HMCN1 PTPRM NTM CD101 IGSF9B VPREB3 OPCML

1.99e-075036712IPR007110
DomainIG

IL1RAPL1 HHLA2 KIRREL3 NEO1 HMCN1 PTPRM NTM CD101 IGSF9B VPREB3 OPCML

2.77e-074216711SM00409
DomainIg_sub

IL1RAPL1 HHLA2 KIRREL3 NEO1 HMCN1 PTPRM NTM CD101 IGSF9B VPREB3 OPCML

2.77e-074216711IPR003599
DomainIg_I-set

IL1RAPL1 KIRREL3 NEO1 HMCN1 NTM CD101 IGSF9B OPCML

3.87e-07190678IPR013098
DomainI-set

IL1RAPL1 KIRREL3 NEO1 HMCN1 NTM CD101 IGSF9B OPCML

3.87e-07190678PF07679
DomainIGc2

IL1RAPL1 IL12B KIRREL3 NEO1 HMCN1 NTM IGSF9B OPCML

1.92e-06235678SM00408
DomainIg_sub2

IL1RAPL1 IL12B KIRREL3 NEO1 HMCN1 NTM IGSF9B OPCML

1.92e-06235678IPR003598
DomainFN3

IL12B NEO1 FN1 PTPRM IL20RA IGSF9B IL23R

7.10e-06199677PS50853
DomainIg_V-set

HHLA2 KIRREL3 HMCN1 CD101 IGSF9B VPREB3 OPCML

7.10e-06199677IPR013106
DomainIGv

HHLA2 HMCN1 CD101 IGSF9B VPREB3

7.26e-0675675SM00406
Domainfn3

IL12B NEO1 FN1 PTPRM IGSF9B IL23R

2.50e-05162676PF00041
DomainV-set

HHLA2 KIRREL3 CD101 IGSF9B VPREB3 OPCML

5.11e-05184676PF07686
DomainFN3

FLNC NEO1 FN1 PTPRM IGSF9B IL23R

5.26e-05185676SM00060
DomainTox-GHH_dom

TENM3 TENM1

7.57e-054672IPR028916
DomainTen_N

TENM3 TENM1

7.57e-054672IPR009471
DomainTen_N

TENM3 TENM1

7.57e-054672PF06484
DomainTENEURIN_N

TENM3 TENM1

7.57e-054672PS51361
DomainTox-GHH

TENM3 TENM1

7.57e-054672PF15636
DomainYD

TENM3 TENM1

1.26e-045672IPR006530
DomainInterfer-bind

IL20RA IFNAR2

5.60e-0410672PF09294
DomainInterferon/interleukin_rcp_dom

IL20RA IFNAR2

5.60e-0410672IPR015373
Domainig

IL1RAPL1 HMCN1 PTPRM NTM OPCML

5.99e-04190675PF00047
DomainImmunoglobulin

IL1RAPL1 HMCN1 PTPRM NTM OPCML

5.99e-04190675IPR013151
DomainBAH

RERE DNMT1

6.83e-0411672SM00439
DomainBAH

RERE DNMT1

6.83e-0411672PF01426
DomainBAH

RERE DNMT1

6.83e-0411672PS51038
DomainBAH_dom

RERE DNMT1

6.83e-0411672IPR001025
DomainTissue_fac

IL20RA IFNAR2

8.18e-0412672PF01108
DomainTissue_factor

IL20RA IFNAR2

8.18e-0412672IPR001187
DomainNHL

TENM3 TENM1

9.64e-0413672PS51125
DomainEGF_1

FBLN2 FN1 HMCN1 TENM3 TENM1

2.21e-03255675PS00022
DomainIg_2

KIRREL3 NEO1 IGSF9B

2.29e-0373673PF13895
DomainEGF-like_CS

FBLN2 FN1 HMCN1 TENM3 TENM1

2.45e-03261675IPR013032
DomaincEGF

FBLN2 HMCN1

3.90e-0326672IPR026823
DomaincEGF

FBLN2 HMCN1

3.90e-0326672PF12662
DomainLIPASE_SER

LIPM LIPH

3.90e-0326672PS00120
DomainSH2

TYK2 PTPN6 BTK

7.24e-03110673SM00252
DomainPTPc

PTPN6 PTPRM

7.38e-0336672SM00194
DomainSH2

TYK2 PTPN6 BTK

7.43e-03111673PS50001
DomainSH2

TYK2 PTPN6 BTK

7.61e-03112673IPR000980
PathwayKEGG_JAK_STAT_SIGNALING_PATHWAY

TYK2 IL12B PTPN6 IL20RA IL23R SOS1 IFNAR2

2.21e-06155557M17411
PathwayREACTOME_INTERLEUKIN_23_SIGNALING

TYK2 IL12B IL23R

3.10e-068553MM15619
PathwayREACTOME_INTERLEUKIN_23_SIGNALING

TYK2 IL12B IL23R

4.64e-069553M27896
PathwayKEGG_MEDICUS_REFERENCE_IL12_23_TO_JAK_STAT_SIGNALING_PATHWAY

TYK2 IL12B IL23R

6.61e-0610553M47907
PathwayWP_TCELL_ACTIVATION_SARSCOV2

TYK2 IL12B IL23R SOS1 IFNAR2

2.30e-0588555M42580
PathwayREACTOME_INTERLEUKIN_12_FAMILY_SIGNALING

TYK2 IL12B IL23R

3.04e-0516553MM15127
PathwayREACTOME_SIGNALING_BY_INTERLEUKINS

TYK2 IL1RAPL1 IL12B PTPN6 FN1 IL20RA CCR1 IL23R SOS1

8.04e-05473559M874
PathwayREACTOME_REGULATION_OF_IFNA_IFNB_SIGNALING

TYK2 PTPN6 IFNAR2

9.42e-0523553MM15634
PathwayREACTOME_SIGNALING_BY_INTERLEUKINS

TYK2 IL1RAPL1 IL12B PTPN6 IL20RA IL23R SOS1

1.04e-04281557MM15130
PathwayPID_LYMPH_ANGIOGENESIS_PATHWAY

FN1 ITGA2 SOS1

1.22e-0425553M274
PathwayREACTOME_REGULATION_OF_IFNA_IFNB_SIGNALING

TYK2 PTPN6 IFNAR2

1.37e-0426553M982
PathwayPID_EPO_PATHWAY

PTPN6 BTK SOS1

2.82e-0433553M233
PathwayREACTOME_INTERFERON_ALPHA_BETA_SIGNALING

TYK2 PTPN6 IFNAR2

3.09e-0434553MM15631
PathwayREACTOME_INTERLEUKIN_12_SIGNALING

TYK2 IL12B

3.10e-047552MM17223
PathwayPID_IL23_PATHWAY

TYK2 IL12B IL23R

3.98e-0437553M196
PathwayREACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM

TYK2 IL1RAPL1 IL12B PTPN6 IL20RA IL23R SOS1 IFNAR2

4.54e-04472558MM14539
PathwayREACTOME_SIGNALING_BY_ALK_IN_CANCER

TYK2 PTPN6 FN1 DNMT1

4.68e-0493554M42521
PathwayBIOCARTA_IFNA_PATHWAY

TYK2 IFNAR2

5.29e-049552M22056
PathwayKEGG_MEDICUS_REFERENCE_CYTOKINE_JAK_STAT_SIGNALING_PATHWAY

IL12B IL23R IFNAR2

7.10e-0445553M47408
PathwayREACTOME_INTERLEUKIN_10_SIGNALING

TYK2 IL12B CCR1

7.10e-0445553M27605
PathwayWP_IL26_SIGNALING

TYK2 IL20RA CTSK

8.07e-0447553M48074
PathwayREACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM

TYK2 IL1RAPL1 IL12B PTPN6 FN1 IL20RA CCR1 IL23R SOS1 IFNAR2

8.39e-047895510M1060
PathwayREACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING

TYK2 IL12B FN1 IL23R

9.12e-04111554M27609
PathwayKEGG_MEDICUS_REFERENCE_IL10_FAMILY_TO_JAK_STAT_SIGNALING_PATHWAY

TYK2 IL20RA

1.13e-0313552M47556
PathwayREACTOME_REGULATION_OF_KIT_SIGNALING

PTPN6 SOS1

1.13e-0313552MM14565
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

PTPN6 BTK SOS1

1.15e-0353553MM15716
PathwayWP_IL4_SIGNALING

TYK2 PTPN6 SOS1

1.21e-0354553M39720
PathwayWP_INTERFERON_TYPE_I_SIGNALING

TYK2 PTPN6 IFNAR2

1.21e-0354553M39435
PathwayREACTOME_SYNDECAN_INTERACTIONS

FN1 ITGA2

1.32e-0314552MM14923
PathwayREACTOME_INTERLEUKIN_12_FAMILY_SIGNALING

TYK2 IL12B IL23R

1.42e-0357553M27381
PathwayREACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS

FN1 SOS1

1.52e-0315552M1262
PathwayBIOCARTA_IL3_PATHWAY

PTPN6 SOS1

1.52e-0315552MM1412
PathwayREACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS

FN1 SOS1

1.52e-0315552MM14959
PathwayBIOCARTA_IL3_PATHWAY

PTPN6 SOS1

1.52e-0315552M17681
PathwayWP_KIT_RECEPTOR_SIGNALING

PTPN6 BTK SOS1

1.57e-0359553M39350
Pubmed

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.

TYK2 IL12B IL23R

2.49e-07768312023369
Pubmed

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.

TYK2 IL12B IL23R

5.95e-07968311114383
Pubmed

IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12.

TYK2 IL12B IL23R

8.49e-071068319088061
Pubmed

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells.

TYK2 IL12B IL23R

1.17e-061168316482511
Pubmed

Gene-targeted deletion of OPCML and Neurotrimin in mice does not yield congenital heart defects.

NTM OPCML

3.77e-06268224616287
Pubmed

Replication of association between interleukin-23 receptor (IL-23R) and its ligand (IL-12B) polymorphisms and psoriasis in the Chinese Han population.

IL12B IL23R

3.77e-06268220875477
Pubmed

Association of IL-23 and its receptor gene single-nucleotide polymorphisms with multiple sclerosis in Chinese southern population.

IL12B IL23R

3.77e-06268224547735
Pubmed

The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritis.

IL12B IL23R

3.77e-06268218512797
Pubmed

IL12B, IL23A, IL23R and HLA-C*06 genetic variants in psoriasis susceptibility and response to treatment.

IL12B IL23R

3.77e-06268229454820
Pubmed

Meta-analysis of the IL23R and IL12B polymorphisms in multiple sclerosis.

IL12B IL23R

3.77e-06268226000455
Pubmed

Association analysis of IL-12B and IL-23R polymorphisms in myocardial infarction.

IL12B IL23R

3.77e-06268217901940
Pubmed

Association between interleukin 12B and interleukin 23R gene polymorphisms and systemic lupus erythematosus: a meta-analysis.

IL12B IL23R

3.77e-06268235086377
Pubmed

IL12B and IL23R gene SNPs in Japanese psoriasis.

IL12B IL23R

3.77e-06268223955419
Pubmed

PTPRM methylation induced by FN1 promotes the development of glioblastoma by activating STAT3 signalling.

FN1 PTPRM

3.77e-06268234225581
Pubmed

Investigation of association of the IL-12B and IL-23R genetic variations with psoriatic risk in a South Indian Tamil cohort.

IL12B IL23R

3.77e-06268226472011
Pubmed

Investigation of association of the IL12B and IL23R genes with psoriatic arthritis.

IL12B IL23R

3.77e-06268219035472
Pubmed

Capturing host-pathogen interactions by protein microarrays: identification of novel streptococcal proteins binding to human fibronectin, fibrinogen, and C4BP.

FN1 C4BPA

3.77e-06268219417080
Pubmed

The autoimmune disease-associated IL12B and IL23R polymorphisms in multiple sclerosis.

IL12B IL23R

3.77e-06268218082575
Pubmed

Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules.

NTM OPCML

3.77e-0626827891157
Pubmed

IL12B SNPs and copy number variation in IL23R gene associated with susceptibility to leprosy.

IL12B IL23R

3.77e-06268223240095
Pubmed

IL23R and IL12B genes: susceptibility analysis in rheumatoid arthritis.

IL12B IL23R

3.77e-06268219525409
Pubmed

Associations between interleukin-23R and interleukin-12B polymorphisms and psoriasis susceptibility: a meta-analysis.

IL12B IL23R

3.77e-06268223844553
Pubmed

IL23R and IL12B polymorphisms in Spanish IBD patients: no evidence of interaction.

IL12B IL23R

3.77e-06268218383521
Pubmed

Interaction of FTO rs9939609 and the native American-origin ABCA1 p.Arg230Cys with circulating leptin levels in Mexican adolescents diagnosed with eating disorders: Preliminary results.

ABCA1 FTO

3.77e-06268232763537
Pubmed

Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population.

ABCA1 FTO

3.77e-06268228464932
Pubmed

Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.

IL12B IL23R

3.77e-06268217587057
Pubmed

DNA methyltransferase 1 mediated aberrant methylation and silencing of SHP-1 gene in chronic myelogenous leukemia cells.

PTPN6 DNMT1

3.77e-06268228376405
Pubmed

Polymorphisms in the IL-12beta and IL-23R genes are associated with psoriasis of early onset in a UK cohort.

IL12B IL23R

3.77e-06268218034172
Pubmed

Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin.

CTSK TG

3.77e-06268211082042
Pubmed

The interaction of the xid and me genes.

PTPN6 BTK

3.77e-0626822884254
Pubmed

OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer.

NTM OPCML

3.77e-06268212819783
Pubmed

Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.

FBLN2 FN1 TENM3 NSG1 PKDCC

5.83e-0613068528705898
Pubmed

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

TYK2 IL12B IL23R

6.77e-061968320953190
Pubmed

Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis.

IL12B IL23R

1.13e-05368218800148
Pubmed

Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase.

TYK2 PTPN6

1.13e-0536828780698
Pubmed

TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo.

IL12B BTK

1.13e-05368216272291
Pubmed

Glucocorticoids down-regulate the extracellular matrix proteins fibronectin, fibulin-1 and fibulin-2 in bone marrow stroma.

FBLN2 FN1

1.13e-05368211737251
Pubmed

Association of extracellular matrix proteins fibulin-1 and fibulin-2 with fibronectin in bone marrow stroma.

FBLN2 FN1

1.13e-05368210848816
Pubmed

IL12B and IL23R polymorphisms are associated with alopecia areata.

IL12B IL23R

1.13e-05368232355229
Pubmed

Investigation of IL-23 (p19, p40) and IL-23R identifies nuclear expression of IL-23 p19 as a favorable prognostic factor in colorectal cancer: a retrospective multicenter study of 675 patients.

IL12B IL23R

1.13e-05368225015728
Pubmed

The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor.

TYK2 IFNAR2

1.13e-05368218456658
Pubmed

DNMT1/miR-152-3p/SOS1 signaling axis promotes self-renewal and tumor growth of cancer stem-like cells derived from non-small cell lung cancer.

DNMT1 SOS1

1.13e-05368238622665
Pubmed

Genetic evidence for involvement of the IL23 pathway in Thai psoriatics.

IL12B IL23R

1.13e-05368219705136
Pubmed

Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase.

TYK2 PTPN6

1.13e-0536827629131
Pubmed

IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production.

IL12B IL23R

1.13e-05368216751425
Pubmed

Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease.

IL12B IL23R

1.13e-05368217993580
Pubmed

Quantitative proteomics revealed novel proteins associated with molecular subtypes of breast cancer.

FN1 C4BPA

1.13e-05368227498393
Pubmed

Polymorphisms of the IL12B and IL23R genes are associated with psoriasis.

IL12B IL23R

1.13e-05368218219280
Pubmed

Exploring ankylosing spondylitis-associated ERAP1, IL23R and IL12B gene polymorphisms in subphenotypes of psoriatic arthritis.

IL12B IL23R

1.13e-05368223093722
Pubmed

Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus.

IL12B IL23R

1.13e-05368224957500
Pubmed

A heritable defect in IL-12 signaling in B10.Q/J mice. II. Effect on acute resistance to Toxoplasma gondii and rescue by IL-18 treatment.

TYK2 IL12B

1.13e-05368211313414
Pubmed

ITGA2 induces STING expression in pancreatic cancer by inducing DNMT1 degradation.

ITGA2 DNMT1

1.13e-05368236331797
Pubmed

Variants in the 5q31 cytokine gene cluster are associated with psoriasis.

IL12B IL23R

1.13e-05368218075513
Pubmed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.

KIRREL3 HMCN1 PTPRM NTM OPCML

1.70e-0516268525826454
Pubmed

Serum amyloid p component does not circulate in complex with C4-binding protein, fibronectin or any other major protein ligand.

FN1 C4BPA

2.25e-05468212100475
Pubmed

A Potential Four-Gene Signature and Nomogram for Predicting the Overall Survival of Papillary Thyroid Cancer.

TENM1 FTO

2.25e-05468236193505
Pubmed

Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity.

PTPN6 ITGA2

2.25e-05468219789387
Pubmed

Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.

TENM3 TENM1

2.25e-05468210225957
Pubmed

Interleukin gene polymorphisms and alopecia areata: A systematic review and meta-analysis.

IL12B IL23R

2.25e-05468238394507
Pubmed

Downregulation of miR-152 contributes to DNMT1-mediated silencing of SOCS3/SHP-1 in non-Hodgkin lymphoma.

PTPN6 DNMT1

2.25e-05468230470842
Pubmed

IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs.

TYK2 IFNAR2

2.25e-05468234813358
Pubmed

Ultrastructural localization of microfibrillar fibulin-1 and fibulin-2 during heart development indicates a switch in molecular associations.

FBLN2 FN1

2.25e-0546829676579
Pubmed

Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development.

IL12B IL23R

2.25e-05468215114670
Pubmed

STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.

PTPN6 DNMT1

2.25e-05468215870198
Pubmed

Association of FTO, ABCA1, ADRB3, and PPARG variants with obesity, type 2 diabetes, and metabolic syndrome in a Northwest Mexican adult population.

ABCA1 FTO

2.25e-05468234420811
Pubmed

Regulation of virus-induced IL-12 and IL-23 expression in human macrophages.

IL12B IL23R

2.25e-05468212421946
Pubmed

Multiple beta 1 integrins mediate enhancement of human airway smooth muscle cytokine secretion by fibronectin and type I collagen.

FN1 ITGA2

2.25e-05468215699160
Pubmed

All four members of the Ten-m/Odz family of transmembrane proteins form dimers.

TENM3 TENM1

2.25e-05468212000766
Pubmed

Selective contribution of Tyk2 to cell activation by lipopolysaccharide.

TYK2 IFNAR2

2.25e-05468218845149
Pubmed

TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among severe COVID-19 ICU patients in Morocco.

TYK2 IFNAR2

2.25e-05468238760017
Pubmed

Non-canonical interleukin 23 receptor complex assembly: p40 protein recruits interleukin 12 receptor β1 via site II and induces p19/interleukin 23 receptor interaction via site III.

IL12B IL23R

2.25e-05468225371211
Pubmed

A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.

KIRREL3 TENM3 TENM1 IGSF9B

3.14e-059168428558017
Pubmed

IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats.

IL12B IL23R

3.75e-05568217888176
Pubmed

The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells.

PTPN6 SOS1

3.75e-0556828632004
Pubmed

Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19.

TYK2 IFNAR2

3.75e-05568236672770
Pubmed

IL-23 Inhibits Melanoma Development by Augmenting DNA Repair and Modulating T Cell Subpopulations.

IL12B BTK

3.75e-05568228003381
Pubmed

IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology.

IL12B IL23R

3.75e-05568225761673
Pubmed

Species-dependent role of type I IFNs and IL-12 in the CTL response induced by humanized CpG complexed with β-glucan.

IL12B IFNAR2

3.75e-05568226786557
Pubmed

A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.

IL12B IL23R

3.75e-05568218369459
Pubmed

Thyroid functions of mouse cathepsins B, K, and L.

CTSK TG

3.75e-05568212782676
Pubmed

Spatiotemporal expression of IgLON family members in the developing mouse nervous system.

NTM OPCML

3.75e-05568234599206
Pubmed

Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan.

FBLN2 FN1

3.75e-05568211493006
Pubmed

Genetic analysis of B cell antigen receptor signaling.

PTPN6 BTK

5.62e-05668210358768
Pubmed

Lack of association between polymorphisms in interleukin (IL)-12, IL-12R, IL-23, IL-23R genes and Takayasu arteritis in a Chinese population.

IL12B IL23R

5.62e-05668226987707
Pubmed

A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.

IL12B IL23R

5.62e-05668217236132
Pubmed

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.

TYK2 IL12B

5.62e-0566828943050
Pubmed

IL-23 promotes tumour incidence and growth.

IL12B IL23R

5.62e-05668216688182
Pubmed

Downregulation of integrins by von Hippel-Lindau (VHL) tumor suppressor protein is independent of VHL-directed hypoxia-inducible factor alpha degradation.

FN1 ITGA2

7.86e-05768218523483
Pubmed

Separation and characterization of the activated pool of colony-stimulating factor 1 receptor forming distinct multimeric complexes with signalling molecules in macrophages.

TYK2 PTPN6

7.86e-05768210330148
Pubmed

TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN.

IL12B IFNAR2

7.86e-05768225529558
Pubmed

Cutting edge: the pathogenicity of IFN-γ-producing Th17 cells is independent of T-bet.

IL12B IL23R

7.86e-05768223543757
Pubmed

Role of integrins in mouse eyelid development: studies in normal embryos and embryos in which there is a failure of eyelid fusion.

FN1 ITGA2

7.86e-0576829858678
Pubmed

IL-12-polarized Th1 cells produce GM-CSF and induce EAE independent of IL-23.

IL12B IL23R

7.86e-05768226220255
Pubmed

The gene for the retinal pigment epithelium-specific protein RPE65 is localized to human 1p31 and mouse 3.

ABCD3 RPE65

7.86e-0576828034329
Pubmed

The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain.

TENM3 TENM1

7.86e-05768212915301
Pubmed

Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity.

IL12B BTK

7.86e-05768234614413
Pubmed

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.

IL12B IL23R

1.05e-04868218438406
Pubmed

The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor.

FBLN2 FN1

1.05e-04868211847210
Pubmed

Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25.

TENM3 TENM1

1.05e-04868210331952
Pubmed

Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.

TYK2 IL12B

1.05e-04868219249008
InteractionAPCS interactions

FN1 CCR1 C4BPA SARAF TG

8.31e-0833685int:APCS
Cytoband11q25

NTM IGSF9B OPCML

7.89e-062668311q25
CytobandEnsembl 112 genes in cytogenetic band chr11q25

NTM IGSF9B OPCML

1.36e-0531683chr11q25
CytobandEnsembl 112 genes in cytogenetic band chr6q23

HBS1L ALDH8A1 IL20RA

7.53e-04119683chr6q23
Cytoband6q23.3

HBS1L IL20RA

7.97e-04286826q23.3
Cytoband1q32

CACNA1S C4BPA

2.43e-03496821q32
Cytoband2p21

PKDCC SOS1

3.74e-03616822p21
Cytoband19p13.2

TYK2 PNPLA6 DNMT1

4.84e-0322968319p13.2
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

IL1RAPL1 KIRREL3 NEO1 HMCN1 PTPRM NTM CD101 IGSF9B OPCML

4.26e-10161499593
GeneFamilyImmunoglobulin like domain containing

IL1RAPL1 IL12B KIRREL3 NEO1 PTPRM CD101 IGSF9B

8.33e-07193497594
GeneFamilyI-set domain containing|IgLON cell adhesion molecules

NTM OPCML

7.16e-0554921052
GeneFamilyFibulins

FBLN2 HMCN1

1.99e-048492556
GeneFamilyFibronectin type III domain containing

NEO1 FN1 PTPRM IGSF9B

9.18e-04160494555
GeneFamilyAdenosine receptors|V-set domain containing

HHLA2 CD101 IGSF9B VPREB3

9.84e-04163494590
GeneFamilyLipases|Arylacetamide deacetylase family

LIPM LIPH

1.61e-0322492464
GeneFamilyTransient receptor potential cation channels

TRPM6 MCOLN2

2.60e-0328492249
GeneFamilyCD molecules|I-set domain containing|Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing

IL1RAPL1 IL20RA

5.78e-0342492602
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

TYK2 EPB41L3

8.11e-03504921293
CoexpressionGSE32986_CURDLAN_LOWDOSE_VS_GMCSF_AND_CURDLAN_LOWDOSE_STIM_DC_UP

STARD8 PNPLA6 SARAF RERE EPB41L3 DNMT1

1.35e-05200686M8625
CoexpressionZHU_SKIL_TARGETS_UP

FN1 ITGA2 DENND2B

1.84e-0520683M2273
CoexpressionAtlasDevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_top-relative-expression-ranked_500

ABCA1 FBLN2 HMCN1 NTM PEG3 PKDCC FTO EPB41L3 PAIP1

3.94e-06388689gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_500
CoexpressionAtlasDevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_top-relative-expression-ranked_1000

ABCA1 NEO1 FBLN2 HMCN1 NTM PEG3 PKDCC FTO EPB41L3 TBC1D8B PAIP1

3.94e-057916811gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_1000
CoexpressionAtlasdev gonad_e12.5_F_VasAssocMesStromOvary_Sma_top-relative-expression-ranked_1000

FLNC NEO1 FN1 HMCN1 TENM3 NSG1 PEG3 FTO EPB41L3 DENND2B MTSS2

4.22e-057976811gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_1000
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_k-means-cluster#1_top-relative-expression-ranked_1000

FLNC TENM3 NSG1 PEG3 DENND2B MTSS2

4.24e-05199686gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_k1_1000
CoexpressionAtlasdev gonad_e12.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000

NEO1 HMCN1 TENM3 ICE2 NSG1 PEG3 VPREB3 DENND2B MTSS2 SOS1 IFNAR2

4.52e-058036811gudmap_dev gonad_e12.5_F_SupCellPrec_Sry_1000
CoexpressionAtlasfacebase_RNAseq_e14.5_palate_poster_oral_Tgfbr2_WT_2500_K4

FLNC PTPN6 ABCA1 FBLN2 FN1 HMCN1 TENM3 PTPRM ICE2 NSG1 PEG3 PKDCC EPB41L3

6.14e-0511486813facebase_RNAseq_e14.5_palate_poster_oral_Tgfbr2_WT_2500_K4
CoexpressionAtlasStromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4

NEO1 FBLN2 FN1 HMCN1 TENM3 PEG3 CTSK OPCML

7.57e-05437688GSM777046_500
CoexpressionAtlasDevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_k-means-cluster#2_top-relative-expression-ranked_1000

ABCA1 NEO1 FBLN2 EPB41L3 PAIP1

9.26e-05142685gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_1000_k2
CoexpressionAtlasDevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_top-relative-expression-ranked_200

ABCA1 FBLN2 HMCN1 NTM PAIP1

1.62e-04160685gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_200
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_top-relative-expression-ranked_1000

FLNC NEO1 FN1 HMCN1 TENM3 NSG1 PEG3 EPB41L3 DENND2B MTSS2

2.12e-047976810gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_1000
CoexpressionAtlasStromal Cells, Ep.MEChi.Th, CD45- EpCAm+ Ly51- MHCIIhi, Thymus, avg-2

NEO1 FN1 LIPH PKDCC EPB41L3 DENND2B IL23R

2.25e-04384687GSM777041_500
ToppCell(2)_Fibroblasts-(20)_Fibro-1|World / Cell class and subclass of bone marrow stroma cells in homeostatis

FLNC FBLN2 FN1 HMCN1 NSG1 CTSK OPCML

1.55e-08188687409a7b69d02e87084ca955e3fe6c77230dee8861
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTPN6 BTK MCM7 VPREB3 DNMT1 MCOLN2

3.70e-07183686956ff95aef9c5521b6a3ba7ac6df0aad242c1c35
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBLN2 HMCN1 TENM3 NTM PEG3 CTSK

4.76e-071916864b50fdd310701251e64e16cd2d07ce03dbfd3e3e
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBLN2 HMCN1 TENM3 NTM PEG3 CTSK

4.76e-0719168675d2197076a9dfc868e8baf95bd4c5e44f438e3e
ToppCellCOPD-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

FN1 HMCN1 TENM3 PTPRM ITGA2 MCOLN2

4.91e-0719268662904f94dfce430456f05066522cbf9bd29f4d7e
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FNBP1 ABCA1 PTPRM RERE EPB41L3 TG

5.06e-07193686779276e775cb2492e8dd36436295a536084a6415
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTPN6 LIPM BTK MCM7 VPREB3

3.39e-06150685cc8361bdcaa16ab6a0d6a3684690d709bc42ff3b
ToppCellfacs-Skin-Telogen-3m-Epithelial-inner_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL1RAPL1 FN1 PEG3 IGSF9B VPREB3

4.11e-06156685ba9dfee9373d657d2a55572b41fc62001ad8b037
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD101 ALDH8A1 CCR1 BCOR PLK3

4.37e-06158685d43b335e6aa12d84a75b988fbd6127ff1f4af25c
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD101 ALDH8A1 CCR1 BCOR PLK3

4.37e-06158685ab12b29ce51ca2fcac469cc932391217d97145f9
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12B CACNA1S IL23R MCOLN2 TG

4.65e-0616068594e4f5fc2156dd8163811c3b8b0781ea9b3f2e06
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

IL1RAPL1 FN1 NTM OPCML TG

4.79e-061616851b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IL1RAPL1 KIRREL3 FBLN2 TENM3 NTM

4.94e-06162685d28b2ea1d2c8f3c6a107991573471b6d0c49c4ae
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IL1RAPL1 KIRREL3 FBLN2 TENM3 NTM

4.94e-061626855bbd7130d4dad9035e73a439dda568195c136f31
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IL1RAPL1 KIRREL3 FBLN2 TENM3 NTM

4.94e-06162685eed223e61c8162a2fe004ab4e09de5e037be7553
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IL1RAPL1 KIRREL3 FBLN2 TENM3 NTM

4.94e-06162685e35ddce830e20ebeac1a2c405293fc4a5323dd4a
ToppCellLV-16._Neuronal|World / Chamber and Cluster_Paper

IL1RAPL1 KIRREL3 TENM3 NTM ITGA2

5.40e-061656856ed52cb756d21addf46c7f6c457458b01339fe04
ToppCellfacs-Heart-RA-18m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1S PTPN6 BTK VPREB3 TG

5.56e-06166685fc2cf67311c86fda75b35fcd4768b6f6f14c59d0
ToppCellfacs-Heart-RA-18m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1S PTPN6 BTK VPREB3 TG

5.56e-0616668533a6876d06e26176135a73a77c19e634ec53f7ce
ToppCellCOVID-19-Heart-Neuronal|Heart / Disease (COVID-19 only), tissue and cell type

IL1RAPL1 KIRREL3 TENM3 NTM ITGA2

6.80e-061736856fb5f9e6536a5d57fd8e6657b494047a2d0bc9c7
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNC FN1 HMCN1 NSG1 OPCML

6.99e-061746851d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 HMCN1 NTM CD101 DENND2B

7.39e-061766859bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 HMCN1 NTM CD101 DENND2B

7.39e-061766853f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCellwk_15-18-Epithelial-PNS-intermediate_Schwann|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

IL1RAPL1 KIRREL3 FBLN2 TENM3 IGSF9B

8.93e-06183685d874aa9a856f79626c8a8371f6196a77b7d662ee
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FBLN2 FN1 HMCN1 TENM3 PEG3

9.41e-06185685c85bba1210f1d389add3e40be9b96abac40cf8c1
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FNBP1 KIRREL3 TENM3 NTM IGSF9B

1.02e-05188685b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNC FBLN2 FN1 EPB41L3 OPCML

1.02e-05188685aa516273cdde53c8c0295f06830972388f890c97
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FNBP1 KIRREL3 TENM3 NTM IGSF9B

1.02e-05188685874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell(2)_Fibroblasts-(22)_Fibro-3|World / Cell class and subclass of bone marrow stroma cells in homeostatis

KIRREL3 TENM3 NTM TTLL5 CTSK

1.07e-051906853aed03b87ba2c8d479048c3ceef3ff5e38746c28
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FBLN2 FN1 TENM3 PEG3 CTSK

1.10e-05191685053b3664f509baa107feaf90730f80ebf9ac8f14
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNC FN1 NSG1 EPB41L3 OPCML

1.13e-0519268530cefa0990ba1f379f350bfbf994a78db145075e
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNC FBLN2 FN1 NSG1 OPCML

1.18e-051946857b6ec45adb7ece3c8a7b78c5782413b5825effe2
ToppCell3'-Pediatric_IBD-SmallIntestine-Neuronal-Glial_mature-Adult_Glia|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIRREL3 FBLN2 HMCN1 TENM3 NTM

1.18e-05194685d429bb5e422a07bd92f0dc48cd51528e8b7d9a72
ToppCell3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IL1RAPL1 PTPN6 NTM BTK SARAF

1.18e-05194685a85e98af9dc9a4f0437be3700d63a6d21415199b
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HMCN1 PTPRM NSG1 PEG3 ITGA2

1.18e-0519468544c7d4b75f3b7c9301eba20610e548a01a84ae40
ToppCell3'-Pediatric_IBD-SmallIntestine-Neuronal|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIRREL3 FBLN2 HMCN1 TENM3 NTM

1.18e-05194685bffdf6db0bf3fb338e7bb0789ae7dcde1fce0094
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HMCN1 PTPRM NSG1 PEG3 ITGA2

1.18e-051946857f24023df47935286f185dd428d48797daf26f49
ToppCell3'-Pediatric_IBD-SmallIntestine-Neuronal-Glial_mature|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIRREL3 FBLN2 HMCN1 TENM3 NTM

1.18e-05194685408dfc7060095972a54ae37ae8105521df6fbbee
ToppCellTCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-8|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

FBLN2 FN1 TENM3 NTM CTSK

1.18e-0519468555b97095a7a17a312c616703d291738a0f806339
ToppCellPCW_05-06-Mesenchymal|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

IL1RAPL1 FN1 TENM3 NTM PKDCC

1.24e-05196685dca52c57ba35d9395cdbca8b881f12ece721b10f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 HMCN1 TENM3 NTM DENND2B

1.24e-05196685fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCellEpithelial_cells-AT1_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

ABCA1 FN1 NTM PKDCC EPB41L3

1.24e-051966856c99d29162848161c1f166a032320f87a5d5a631
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 HMCN1 TENM3 NTM DENND2B

1.24e-05196685802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNC FBLN2 FN1 NSG1 OPCML

1.24e-05196685ed6047b48b6a96baa6a90c7af784e7c34b32824d
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Neuronal-Subcortical|1_mon / Sample Type, Dataset, Time_group, and Cell type.

KIRREL3 NTM NSG1 SARAF AMER3

1.24e-05196685bf8fe28193348342987d361c8e8b9e1d6d542678
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTPN6 ABCA1 FN1 EPB41L3 CTSK

1.27e-051976851ded28732ea5d1f9ebca0b136575103540600ff1
ToppCell(2)_Fibroblasts-(22)_Fibro-3|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis

KIRREL3 TENM3 NTM TTLL5 CTSK

1.27e-05197685d9021bab82403e566ec10f78acb227c0f80b88fe
ToppCellCD8+_Memory_T_cell-CV-3|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

CD101 NSG1 MCM7 PLK3 DNMT1

1.27e-051976859fe3d53346a95c1bbb0fc6a2f2e974889873424b
ToppCellTracheal-10x5prime-Stromal-Schwann-Schwann_nonmyelinating|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

KIRREL3 TENM3 NTM TENM1 OPCML

1.27e-05197685e239caae24f40564a24ad909754f5436f767ccdb
ToppCellCV-Moderate-3|CV / Virus stimulation, Condition and Cluster

CD101 NSG1 MCM7 PLK3 DNMT1

1.27e-051976857031286e300eaccf73b927939f8de3a9d2d5fc74
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

NEO1 FN1 HMCN1 TENM3 ITGA2

1.27e-05197685f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ABCA1 FN1 BTK CCR1 EPB41L3

1.31e-05198685579a22199643440b98e381147779ced630d4ed66
ToppCellCOVID-19-lung-Fibroblast|COVID-19 / Disease (COVID-19 only), tissue and cell type

FN1 HMCN1 TENM3 ITGA2 MCOLN2

1.31e-051986853ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCellMacrophages-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

ABCA1 FN1 CCR1 EPB41L3 CTSK

1.31e-051986858517386a2f0d14c7d5fc6283e4e16b94d7c5732a
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-cortical_neurons_1|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

NEO1 NTM NSG1 EPB41L3 OPCML

1.31e-05198685d81f35c0066558ff96dd06f58fca72cd82e681e8
ToppCellEpithelial_cells-AT1-AT2_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

ABCA1 FN1 NTM PKDCC EPB41L3

1.31e-05198685fbc46b20bcd44f2083170aacbc6f5dd00fba685c
ToppCelldistal-Hematologic-Alveolar_Macrophage-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PTPN6 PNPLA6 FN1 CD101 BTK

1.34e-051996852918967da22602404c767d948fed6c4754e53518
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ABCA1 FN1 TENM3 NTM MCOLN2

1.34e-05199685a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-2,_SCARA5|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

FBLN2 FN1 NTM PKDCC CTSK

1.37e-052006852022df85df94ab8cbb4e80e3fe9894c01051c5e0
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTPN6 ABCA1 FN1 CCR1 EPB41L3

1.37e-0520068526df6ac63710655604888c3be6509b6c4befc0be
ToppCellLung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-4-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FBLN2 FN1 HMCN1 PKDCC CTSK

1.37e-052006854dbe21cb63569f28c7017cda065ea5ee00d7254e
ToppCellParenchyma_COVID-19-Stromal-TX-Fibroblasts-4|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

FBLN2 FN1 HMCN1 PKDCC CTSK

1.37e-05200685bde938e5a18844fb8cc1d1be5a086809f7e2b97d
ToppCellLung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-4|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

FBLN2 FN1 HMCN1 PKDCC CTSK

1.37e-052006858256511b099c3eab8e33194f90c9ff354e7cfe8e
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FN1 HMCN1 TENM3 ITGA2 MCOLN2

1.37e-0520068534f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / Treatment groups by lineage, cell group, cell type

FBLN2 FN1 HMCN1 PTPRM NSG1

1.37e-05200685b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCellParenchymal-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FBLN2 HMCN1 TENM3 NTM CTSK

1.37e-0520068554806080b5e97859ee6a4a9b4f19e22021c218f5
ToppCellBiopsy_IPF-Mesenchymal-HAS1_High_Fibroblasts|Biopsy_IPF / Sample group, Lineage and Cell type

FLNC FBLN2 HMCN1 TENM3 CTSK

1.37e-05200685d02e256b5d65a5c982ba5696bc7e077281ca3e24
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTPN6 ABCA1 FN1 CCR1 EPB41L3

1.37e-0520068507819a90ac347883b78d0bb3cd8c5eb0d66e1e22
ToppCellControl-Neutrophil|Control / Disease condition and Cell class

TRPM6 FLNC SARAF AMER3

4.16e-05126684450c01d89714feee6529680ec3ce69067a54b37c
ToppCellControl-Neutrophil-|Control / Disease condition and Cell class

TRPM6 FLNC SARAF AMER3

4.16e-0512668465fff5ec2296272e94f44546606587833191dd82
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 HMCN1 ITGA2 EPB41L3

5.76e-0513768485b3a98039c1f68addad0334aa5b2584f6045aaa
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

IL1RAPL1 KIRREL3 NTM OPCML

7.37e-05146684c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Rasd1_(Presubiculum,_Col5a2+)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CFAP91 ALDH8A1 IL20RA

7.75e-0554683e40294b708b06f7eee1c099fc67f53a3bb76e306
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Rasd1_(Presubiculum,_Col5a2+)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CFAP91 ALDH8A1 IL20RA

7.75e-0554683a1b3f38a90ca975a3e9c4dadfe3cd4e701a6cb1e
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIRREL3 HMCN1 CD101 CCR1

7.77e-05148684b4632029ebd14969bda59a1bd1454eadb8efe563
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIRREL3 HMCN1 CD101 CCR1

7.77e-05148684ba277c898678dd36f8dc1d681301c71901b89055
ToppCellHippocampus-Hematopoietic|Hippocampus / BrainAtlas - Mouse McCarroll V32

PTPN6 LIPH BTK CCR1

8.40e-0515168481b2189afd72658f7e2539b856ba79cd49340215
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FBLN2 NTM IGSF9B OPCML

9.30e-0515568477fdae85d36efb776db977eb424b32487ef222e4
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BTK MCM7 VPREB3 MCOLN2

9.53e-051566846f8622716bad4e505f241a2a4ef953bf3fc6dbfa
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KIRREL3 TENM3 NTM IGSF9B

9.53e-05156684dd41ed918b07fa248da458a629b3c53cb7ea8764
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KIRREL3 TENM3 NTM IGSF9B

9.53e-05156684abf9dd075b1ca8f613c660cc82f8a5af071fb6ab
ToppCellfacs-Lung-24m-Hematologic-myeloid-neutrophil|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD101 ALDH8A1 CCR1 PLK3

9.77e-05157684e96241db2b5ff52b230e3e33207e7bb968900cab
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NSG1 PEG3 MCM7 DNMT1

9.77e-051576842c946c6ab284fac3c25db688ed0aabe5a3f9ffa5
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Myeloid-mast_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN6 CD101 CCR1 PLK3

9.77e-05157684cca7f23485b9d1a1c96134b6ca85dc7dba0c0522
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Myeloid|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN6 CD101 CCR1 PLK3

9.77e-05157684241c983fc3fc5c98113baf27e03ff0eede611bd8
ToppCellfacs-Lung-24m-Hematologic-myeloid-neutrophil-neutrophil|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD101 ALDH8A1 CCR1 PLK3

9.77e-0515768407a0f8d29a3111be670eae030a91474465eba734
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

IL1RAPL1 KIRREL3 NTM OPCML

1.03e-041596845335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellFrontal_cortex-Hematopoietic-MICROGLIA|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PTPN6 LIPH CD101 BTK

1.03e-0415968441d2c1e71f6983156f8cc8ec5f69e025e5700f46
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN6 LIPH CD101 BTK

1.05e-0416068497c899df1b57fd2bd1867e02bfedf1920c00ad17
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD101 MCM7 DNMT1 TG

1.05e-04160684ec81814f3a475ba9bc049cb793bf93bc0b650d37
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN6 CD101 CCR1 PLK3

1.08e-04161684e227f7b711475624cf80e77f235b1783d88d57b4
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1S BTK MCOLN2 TG

1.08e-041616847af3b0d4fc7967f6b3e2d255d23fd8b1fd01a7af
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IL1RAPL1 KIRREL3 TENM3 NTM

1.08e-041616847d1bc73f4c82465b3f489d6737048b0cd54f22cf
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IL1RAPL1 KIRREL3 TENM3 NTM

1.08e-04161684410eef62c83c704cbfc5a1b643c4db11bbdcd81f
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN6 CD101 CCR1 PLK3

1.08e-041616848280a029026c272cae9649b27575831b0dd4e242
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IL1RAPL1 KIRREL3 TENM3 NTM

1.08e-0416168471022485da6754a2b57b4c3e758e3de4c95cc292
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-Zbtb32+_B_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1S BTK MCOLN2 TG

1.08e-0416168498be0cf8228496b31f7f3e0efd8787e95eb626d1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IL1RAPL1 KIRREL3 TENM3 NTM

1.08e-0416168459ae8a7c9a04ecaa335b8064852a5a91a21780bd
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN2 FN1 NTM OPCML

1.10e-0416268456f1789e69a6cb29956e46aba92b290847327c1f
ToppCell10x5'-Liver-Lymphocytic_Invariant-Inducer-like-ILC3|Liver / Manually curated celltypes from each tissue

NEO1 PEG3 PKDCC IL23R

1.13e-041636847f61483eeb1fde21843c6391468e13cb0cc2a89f
ComputationalTestis genes.

FBLN2 PEG3 ABCD3 EPB41L3 DENND2B PAIP1 DNMT1

1.50e-04310417MODULE_72
Drug201 Tl

RERE TG

2.55e-053672CID000072170
Drug(-)-MK 801 hydrogen maleate [77086-19-2]; Up 200; 11.8uM; MCF7; HT_HG-U133A

IL12B HBS1L CCR1 RERE OPCML SOS1

2.57e-051986766458_UP
DrugChlorthalidone [77-36-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A

STARD8 PTPRM TTLL5 CD101 IL20RA PLK3

2.57e-051986766800_UP
DrugFurosemide [54-31-9]; Up 200; 12uM; MCF7; HT_HG-U133A

FLNC HBS1L TTLL5 CCR1 VPREB3 OPCML

2.57e-051986763197_UP
DrugAlfuzosin hydrochloride [81403-68-1]; Up 200; 9.4uM; MCF7; HT_HG-U133A

IL12B HBS1L ABCA1 FN1 TENM3 CD101

2.65e-051996763203_UP
DrugAmiloride hydrochloride dihydrate [17440-83-4]; Up 200; 13.2uM; MCF7; HT_HG-U133A

IL12B CACNA1S TTLL5 RERE OPCML MTSS2

2.72e-052006764109_UP
DrugCP-944629 [668990-94-1]; Down 200; 10uM; MCF7; HT_HG-U133A

HBS1L ABCA1 RERE RXYLT1 PLK3 IFNAR2

2.72e-052006767544_DN
DiseaseCrohn's disease of large bowel

TYK2 IL12B FN1 IL23R

3.08e-0644674C0156147
DiseaseIIeocolitis

TYK2 IL12B FN1 IL23R

3.08e-0644674C0949272
DiseaseCrohn's disease of the ileum

TYK2 IL12B FN1 IL23R

3.08e-0644674C0267380
DiseaseRegional enteritis

TYK2 IL12B FN1 IL23R

3.08e-0644674C0678202
DiseaseCrohn Disease

TYK2 IL12B FN1 IL23R

5.17e-0650674C0010346
Diseaseautoimmune thyroid disease, systemic lupus erythematosus, type 1 diabetes mellitus, ankylosing spondylitis, psoriasis, common variable immunodeficiency, celiac disease, ulcerative colitis, Crohn's disease, autoimmune disease, juvenile idiopathic arthritis

FNBP1 IL12B TENM3 IL23R

1.99e-0570674EFO_0000384, EFO_0000676, EFO_0000729, EFO_0001060, EFO_0002609, EFO_0003898, EFO_0005140, EFO_0006812, MONDO_0005147, MONDO_0007915, MONDO_0015517
Diseasepsoriasis, type 2 diabetes mellitus

TYK2 IL12B FTO IL23R

2.61e-0575674EFO_0000676, MONDO_0005148
Diseaserespiratory failure, COVID-19

TYK2 PTPRM IFNAR2

3.92e-0529673EFO_0009686, MONDO_0100096
DiseaseGraves' disease (is_implicated_in)

IL23R DNMT1 TG

9.64e-0539673DOID:12361 (is_implicated_in)
Diseaselongitudinal alcohol consumption measurement

MIPOL1 IGSF9B

1.81e-049672EFO_0007645
DiseaseColorectal Carcinoma

FLNC ABCA1 FBLN2 STARD8 FN1 PEG3 ABCD3 TENM1

1.87e-04702678C0009402
Diseaseprimary biliary cirrhosis

TYK2 IL12B CACNA1S IL20RA

2.43e-04133674EFO_1001486
DiseaseAnkylosing spondylitis

IL12B IL23R

2.76e-0411672C0038013
DiseaseParanoia

TYK2 ICE2

2.76e-0411672C1456784
DiseasePsoriasis

TYK2 IL12B IL23R

3.00e-0457673C0033860
DiseasePustulosis of Palms and Soles

TYK2 IL12B IL23R

3.00e-0457673C0030246
Diseasepsoriasis vulgaris

TYK2 IL12B IL23R

3.66e-0461673EFO_1001494
Diseasesarcoidosis

TYK2 IL12B IL23R

4.22e-0464673MONDO_0019338
DiseaseColorectal Neoplasms

FLNC ABCA1 FBLN2 STARD8 ABCD3

4.22e-04277675C0009404
Diseaseurate measurement, bone density

TRPM6 FNBP1 KIRREL3 NTM PKDCC FTO TG

5.06e-04619677EFO_0003923, EFO_0004531
Diseasetestosterone measurement

TYK2 TRPM6 STARD8 HMCN1 ICE2 FTO LARP4 RPE65 SOS1 IFNAR2

5.77e-0412756710EFO_0004908
Diseasebehavioural disinhibition measurement

KIRREL3 FN1 RXYLT1

6.72e-0475673EFO_0006946
DiseaseCOVID-19, osteoarthritis

TYK2 IFNAR2

9.40e-0420672MONDO_0005178, MONDO_0100096
Diseasepsoriatic arthritis

TYK2 IL12B IL23R

1.03e-0387673EFO_0003778
Diseaserheumatoid arthritis, ulcerative colitis

TYK2 IL23R

1.04e-0321672EFO_0000685, EFO_0000729
DiseaseBehcet Syndrome

CCR1 IL23R

1.36e-0324672C0004943
DiseaseICAM-1 measurement

TYK2 DNMT1

1.36e-0324672EFO_0004520
DiseaseBreast Carcinoma

STARD8 FN1 BTK FTO EPB41L3 DNMT1

1.39e-03538676C0678222
DiseaseVitiligo

IL1RAPL1 RERE TG

1.59e-03101673EFO_0004208
Diseaseanogenital venereal wart (is_marker_for)

IL12B PTPN6

1.59e-0326672DOID:11168 (is_marker_for)
Diseasemalaria

IL1RAPL1 IL20RA IL23R

1.64e-03102673EFO_0001068
Diseaseneuroticism measurement, cognitive function measurement

TENM3 IGSF9B RERE FTO OPCML TG

1.80e-03566676EFO_0007660, EFO_0008354
Diseasebiological sex

NTM IGSF9B FTO OPCML

1.88e-03230674PATO_0000047
Diseasehepatocellular carcinoma (biomarker_via_orthology)

ABCA1 MCM7 DNMT1

1.93e-03108673DOID:684 (biomarker_via_orthology)
DiseaseEarly Pregnancy Loss

IL12B FN1 IL20RA

1.98e-03109673C3830362
DiseaseSpontaneous abortion

IL12B FN1 IL20RA

1.98e-03109673C0000786
DiseaseMiscarriage

IL12B FN1 IL20RA

1.98e-03109673C4552766
DiseaseAbortion, Tubal

IL12B FN1 IL20RA

1.98e-03109673C0000822

Protein segments in the cluster

PeptideGeneStartEntry
QPESVSTSDEGYYDS

AMER3

376

Q8N944
DSEDAYPYVGQEESC

CTSK

196

P43235
YVEPENVTIQCDSGY

C4BPA

501

P04003
CSSYIDSYDPSTGEV

ALDH8A1

21

Q9H2A2
TVEYGEDLPECVQVY

DNMT1

1061

P26358
EGYIPSNYVTEAEDS

BTK

261

Q06187
EDAETFYDNSTTPYC

ABCA1

341

O95477
TFSECSYPETEEEGE

DENND2B

231

P78524
YGSSVCEPDDESGYD

BCOR

1601

Q6W2J9
QTDPYSAEYVVCQDS

CFAP91

201

Q7Z4T9
LYGQSVEDDYCISPS

HBS1L

21

Q9Y450
EQPAGACEYSYCEDE

PNPLA6

471

Q8IY17
EDTSTPGVPTCYYDT

MGAM2

936

Q2M2H8
EIQNVDVYDEGPYTC

NTM

101

Q9P121
DVYDEGPYTCSVQTD

NTM

106

Q9P121
IISSYPDDESVYCTT

MIPOL1

66

Q8TD10
QGYPCEEYEVATEDG

LIPM

56

Q5VYY2
AVAVYSYSCEGPEEE

FTO

241

Q9C0B1
PYSYDQEVAEVEAAT

FBLN2

196

P98095
VDSVEEGDLGNYSCY

IL1RAPL1

321

Q9NZN1
GSEECVFYTDETASP

MTSS2

611

Q765P7
ANEPTYFTVDCSEAG

FLNC

781

Q14315
DSGEYLCNISSDEYT

HHLA2

311

Q9UM44
TQCIPEGLESYYAEQ

NSG1

121

P42857
ESCTITAYPCDSYQD

LIPH

261

Q8WWY8
EYEYSVECQEDSACP

IL12B

186

P29460
NQYYTTGVCSDISPD

ITGA2

141

P17301
EEPYYDCHECTETFT

PEG3

1501

Q9GZU2
YEYDVRTTDICAGPE

IL20RA

401

Q9UHF4
TYTCDQCGAETYQPI

MCM7

181

P33993
ESYEDGCEDYPTLSE

PAIP1

146

Q9H074
ASVTPYDNGEYICVA

HMCN1

1326

Q96RW7
IYGTVNEDAGDYTCV

HMCN1

4406

Q96RW7
GISYDSPDYTDESCT

IFNAR2

26

P48551
DVYDEGPYTCSVQTD

OPCML

106

Q14982
DGSYVNLYDSCVDDT

PARP11

301

Q9NR21
YPPEYTCSSETDAQS

FAM189B

251

P81408
TEEETGVYQCEVEVY

CD101

631

Q93033
EYQACYGVEALTESE

ICE2

776

Q659A1
DEEGYVPTSYVEVCL

FNBP1

596

Q96RU3
ESDYAPGEEYTCGTN

CACNA1S

1341

Q13698
DTTTEFDYGDATPCQ

CCR1

11

P32246
DPVDQCQDSETGTFY

FN1

556

P02751
DIPDEVTCVIYEYSG

IL23R

126

Q5VWK5
SCEEIEYPATISYSS

ASIC5

376

Q9NY37
PEDLSYQIYDVSGES

LARP4

96

Q71RC2
TTVDYTYFSEPVSCE

KIRREL3

301

Q8IZU9
IYEACSYGSIPVVED

RXYLT1

341

Q9Y2B1
YTVQSELGDYDPDEC

EPB41L3

231

Q9Y2J2
GTDEDDYSCSVYTQE

MCOLN2

111

Q8IZK6
APCYESDTDIYETVA

DRICH1

21

Q6PGQ1
EPYSTCGYSQSEGDD

PTPRM

31

P28827
VYPVGEDYYACTETN

RPE65

136

Q16518
GYCYQDSEDIPDTLT

PKDCC

216

Q504Y2
VVSCEGYESSEDQYV

SARAF

111

Q96BY9
KPDEGYYQCVATVES

NEO1

121

Q92859
ELSSGEEYYVACDNT

TENM1

2306

Q9UKZ4
EEYYVACDNTGTPLA

TENM1

2311

Q9UKZ4
SYITEDDVVYRPGDC

RERE

96

Q9P2R6
EEPSTSGEQTYYDLV

SOS1

191

Q07889
SPDNVCYEGQSAYDV

STARD8

626

Q92502
ECTSAVSVDVEGYIY

ABCD3

596

P28288
CYEATDTETGSAYAV

PLK3

76

Q9H4B4
IYGEVYAGEIDVCSS

TRPM6

1021

Q9BX84
PDYYTEVVEQSLGTC

TBC1D8B

511

Q0IIM8
EATEEALGTYTCVPY

IGSF9B

386

Q9UPX0
EAVVSVGYEYESCLD

TENM3

1076

Q9P273
PYSVTNCGEHDTTEY

PTPN6

376

P29350
TISPVQPEDDADYYC

VPREB3

101

Q9UKI3
FVPSCTTEGSYEDVQ

TG

616

P01266
SGDYVSCDDPEVEDY

TTLL5

276

Q6EMB2
VSLYCYDPTNDGTGE

TYK2

911

P29597