Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainGYF

GIGYF2 GIGYF1

5.59e-063262SM00444
DomainGYF

GIGYF2 GIGYF1

5.59e-063262PS50829
DomainGYF

GIGYF2 GIGYF1

5.59e-063262PF02213
Domain-

GIGYF2 GIGYF1

5.59e-0632623.30.1490.40
DomainGYF

GIGYF2 GIGYF1

1.12e-054262IPR003169
DomainDUF4195

ZNF280D ZNF280C

1.12e-054262IPR025243
DomainDUF4195

ZNF280D ZNF280C

1.12e-054262PF13836
DomainTPR_8

IFIT1 TONSL

2.46e-0353262PF13181
Domain-

SPTA1 STXBP4 PLCE1

5.53e-032612631.10.238.10
DomainEF-hand-dom_pair

SPTA1 STXBP4 PLCE1

7.19e-03287263IPR011992
Pubmed

Expression of MAGE genes in primary and metastatic cutaneous melanoma.

MAGEA2 MAGEA3

1.87e-0632827591235
Pubmed

4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay.

GIGYF2 GIGYF1

3.75e-06428233053355
Pubmed

A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma.

MAGEA2 MAGEA3

3.75e-0642821840703
Pubmed

Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.

MAGEA2 MAGEA3

3.75e-0642828113684
Pubmed

Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling.

GIGYF2 GIGYF1

6.24e-06528212771153
Pubmed

The adapter protein GRB10 is an endogenous negative regulator of insulin-like growth factor signaling.

GIGYF2 GIGYF1

6.24e-06528216037382
Pubmed

Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis.

GIGYF2 GIGYF1

9.36e-06628220878056
Pubmed

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.

GIGYF2 GIGYF1

9.36e-06628228698298
Pubmed

GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling.

GIGYF2 GIGYF1

9.36e-06628219744960
Pubmed

A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.

GIGYF2 GIGYF1

1.31e-05728222751931
Pubmed

GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling.

GIGYF2 GIGYF1

1.31e-05728230917308
Pubmed

MAGE A1-A6 RT-PCR and MAGE A3 and p16 methylation analysis in induced sputum from patients with lung cancer and non-malignant lung diseases.

MAGEA2 MAGEA3

1.31e-05728222134685
Pubmed

Expression of melanoma-associated antigens in oral squamous cell carcinoma.

MAGEA2 MAGEA3

1.31e-05728218197853
Pubmed

Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters.

MAGEA2 MAGEA3

1.31e-05728217634428
Pubmed

Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression.

GIGYF2 GIGYF1

2.24e-05928231439631
Pubmed

Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.

ZNF280D MGA ZNF280C

2.92e-057428329795351
Pubmed

The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28.

MAGEA2 MAGEA3

5.65e-05142828575766
Pubmed

Structure, chromosomal localization, and expression of 12 genes of the MAGE family.

MAGEA2 MAGEA3

6.52e-05152827927540
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ZNF280D STAG1 MGA LCORL ZNF280C

1.13e-0460828536089195
Pubmed

Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

ZNF280D TAF11 MGA

1.36e-0412428320850016
Pubmed

Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.

ZNF280D MGA ZNF280C

1.39e-0412528332891193
Pubmed

Comparative genome sequence analysis of the Bpa/Str region in mouse and Man.

MAGEA2 MAGEA3

1.43e-042228210854409
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

GIGYF2 GIGYF1 URGCP PLCE1 TONSL

1.55e-0465028538777146
Pubmed

MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.

MAGEA2 MAGEA3

3.05e-043228220864041
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

GIGYF2 ZNF280D MGA LCORL

3.35e-0441828434709266
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

GIGYF2 STRN GIGYF1 STXBP4

4.28e-0444628424255178
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

GIGYF2 GIGYF1 MGA

4.33e-0418428332908313
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

GIGYF2 STRN MGA PDZRN3 STXBP4

5.39e-0485328528718761
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

GIGYF2 STRN MGA

6.81e-0421528335973513
Pubmed

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.

MGA SPTA1 TONSL

7.87e-0422628331452512
CytobandXq28

MAGEA2 MAGEA3

5.17e-03176282Xq28
CytobandEnsembl 112 genes in cytogenetic band chr10q23

IFIT1 PLCE1

6.31e-03195282chr10q23
CytobandEnsembl 112 genes in cytogenetic band chrXq28

MAGEA2 MAGEA3

7.48e-03213282chrXq28
GeneFamilyMAGE family

MAGEA2 MAGEA3

6.36e-04401721136
GeneFamilyPDZ domain containing

PDZRN3 STXBP4

8.79e-031521721220
GeneFamilyAnkyrin repeat domain containing

ACAP3 TONSL

2.13e-02242172403
CoexpressionGSE40274_CTRL_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN

MAGEA3 GIGYF1 STXBP4 ACAP3

2.32e-05164274M9113
CoexpressionLIANG_SILENCED_BY_METHYLATION_2

MAGEA2 MAGEA3 IFIT1

2.90e-0558273M18085
CoexpressionGSE5542_IFNG_VS_IFNA_AND_IFNG_TREATED_EPITHELIAL_CELLS_24H_UP

STRN SCRN3 MGA IFIT1

5.03e-05200274M6535
CoexpressionAtlasDevelopingGonad_e11.5_ovary + mesonephros_emap-3226_top-relative-expression-ranked_1000

GIGYF2 AMHR2 ZNF280D MGA LCORL SPTA1 STXBP4

6.99e-05815287gudmap_developingGonad_e11.5_ovary + mesonephros_1000
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#3_top-relative-expression-ranked_100

AMHR2 LCORL

1.51e-0414282gudmap_developingGonad_e12.5_ovary_k3_100
CoexpressionAtlasDevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#1_top-relative-expression-ranked_1000

GIGYF2 STRN ACSS2 LCORL

1.58e-04210284gudmap_developingGonad_e14.5_ ovary_1000_k1
CoexpressionAtlasDevelopingGonad_e11.5_testes and mesonephros_emap-3226_k-means-cluster#3_top-relative-expression-ranked_1000

AMHR2 LCORL

1.74e-0415282gudmap_developingGonad_e11.5_testes and mesonephros_k3_1000
CoexpressionAtlasDevelopingGonad_e11.5_ovary + mesonephros_emap-3226_top-relative-expression-ranked_500

GIGYF2 AMHR2 MGA LCORL SPTA1

1.93e-04417285gudmap_developingGonad_e11.5_ovary + mesonephros_500
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#5_top-relative-expression-ranked_500

GIGYF2 AMHR2 LCORL

2.31e-0491283gudmap_developingGonad_e12.5_ovary_k5_500
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#2_top-relative-expression-ranked_200

AMHR2 LCORL

2.83e-0419282gudmap_developingGonad_e16.5_epididymis_200_k2
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|368C / Donor, Lineage, Cell class and subclass (all cells)

CLCN2 MGA LCORL STXBP4

5.13e-06184284d48807f9da48bdd015a54c606d2e2a311f181396
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CLCN2 MGA LCORL STXBP4

5.24e-061852847925519b855f76444a0b57382ce35d89457b0b14
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

GIGYF2 STRN MGA LCORL

6.20e-06193284abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
Diseasecortical surface area measurement

AMHR2 STRN CLCN2 STAG1 LCORL PDZRN3 PLCE1

1.60e-041345277EFO_0010736
Diseaseneuroimaging measurement

STRN STAG1 LCORL PDZRN3 PRG2 PLCE1

3.43e-041069276EFO_0004346
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

GIGYF2 GIGYF1

9.23e-0449272DOID:0060037 (implicated_via_orthology)
Diseasehemoglobin A1 measurement

STRN MGA LCORL SPTA1

1.21e-03520274EFO_0007629
Diseasebody surface area

GIGYF2 AMHR2 ACSS2 LCORL

2.63e-03643274EFO_0022196
Diseaseorofacial cleft, sex interaction measurement

PRG2 PLCE1

2.81e-0386272EFO_0008343, MONDO_0000358
Diseasefeeling nervous measurement

STAG1 MGA

2.88e-0387272EFO_0009597
Diseaseschizophrenia, intelligence, self reported educational attainment

GIGYF2 STAG1 LCORL

3.79e-03346273EFO_0004337, EFO_0004784, MONDO_0005090
Diseasenon-high density lipoprotein cholesterol measurement

GIGYF1 LCORL SPTA1 PLCE1

3.81e-03713274EFO_0005689
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

STAG1 LCORL PLCE1

4.37e-03364273EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Diseasecataract

LCORL PLCE1

7.36e-03141272MONDO_0005129
Diseasebilirubin measurement

GIGYF2 STAG1 SPTA1

7.48e-03442273EFO_0004570
Diseaseserum alanine aminotransferase measurement

STRN STAG1 LCORL PLCE1

7.64e-03869274EFO_0004735
Diseaseblood urea nitrogen measurement

STAG1 LCORL PLCE1

7.95e-03452273EFO_0004741
Diseaseserum gamma-glutamyl transferase measurement

STRN STAG1 LCORL PLCE1

9.10e-03914274EFO_0004532
Diseaselymphocyte count

GIGYF1 LCORL PRG2 SPTA1 PLCE1

9.68e-031464275EFO_0004587
Diseaseeosinophilic esophagitis

TOGARAM2 URGCP

9.72e-03163272EFO_0004232

Protein segments in the cluster

PeptideGeneStartEntry
ELFMECEEEELEPWQ

ZNF280D

16

Q6N043
GEDMEWDAELFALEP

C13orf42

281

A0A1B0GVH6
DSWEPELLKLMCELG

ACAP3

461

Q96P50
ELMQEAGDECEPEWC

ACSS2

291

Q9NR19
DPDGLRELLEDCWDA

AMHR2

476

Q16671
ARPELQLDEGWMDDD

PDZRN3

501

Q9UPQ7
IEGDCAPEEKIWEEL

MAGEA2

211

P43356
REGDCAPEEKIWEEL

MAGEA3

211

P43357
EDKDGLPEWCLDDED

GIGYF1

286

O75420
LPEWCLDDEDEEMGT

GIGYF1

291

O75420
MDLEDCALWEGKPRT

MGA

996

Q8IWI9
LFEDCEPEELTDWSM

LCORL

71

Q8N3X6
MEETPCRELEEEEEW

PRG2

46

P13727
PEWCLEDAEEEMGTF

GIGYF2

286

Q6Y7W6
MECPEIDCEEGWALL

IFIT1

136

P09914
DGTDWEKEDQCLMPE

STRN

306

O43815
DIRWVCEDMGLKDPE

TMEM132A

996

Q24JP5
PEWEEEEEMDLRACK

TOGARAM2

466

Q6ZUX3
VELDCWDGDDGMPII

PLCE1

1436

Q9P212
VEEALDVCEKWGEMP

TAF11

166

Q15544
WGREEVCDEEALLGM

SCRN3

96

Q0VDG4
EMEGCAWTLEGEEEE

NAP1L5

126

Q96NT1
ALLDMDCLPYGWEEA

STXBP4

491

Q6ZWJ1
DLEGEMSPEEILEWE

CLCN2

761

P51788
IADLEWREMEGDDCE

URGCP

36

Q8TCY9
PEEECLAGDWLELDM

TONSL

826

Q96HA7
LKDWECMTELLLEEP

STAG1

496

Q8WVM7
ELEEWISEMLPTACD

SPTA1

1511

P02549
AELFMECEEEELEPW

ZNF280C

16

Q8ND82