Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaminoacyl-tRNA editing activity

IARS1 LARS1 TARS2

4.79e-05141043GO:0002161
GeneOntologyMolecularFunctionMHC protein complex binding

HLA-DRB1 HLA-DRB3 HLA-DRB4 LILRB5

6.06e-05411044GO:0023023
GeneOntologyMolecularFunctionpeptide antigen binding

HLA-DRB1 HLA-DRB3 HLA-DRB4 MAML1

1.23e-04491044GO:0042605
GeneOntologyMolecularFunctionMHC class II protein complex binding

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.67e-04271043GO:0023026
GeneOntologyMolecularFunctionacetyl-CoA C-acyltransferase activity

ACAT1 SCP2

5.55e-0471042GO:0003988
GeneOntologyBiologicalProcessaminoacyl-tRNA metabolism involved in translational fidelity

IARS1 LARS1 TARS2

3.53e-05131053GO:0106074
GeneOntologyBiologicalProcesspositive regulation of long-term synaptic depression

MAPT IQSEC2 LILRB5

4.48e-05141053GO:1900454
GeneOntologyBiologicalProcessMHC class II protein complex assembly

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.84e-05161053GO:0002399
GeneOntologyBiologicalProcesspeptide antigen assembly with MHC class II protein complex

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.84e-05161053GO:0002503
GeneOntologyBiologicalProcessmyeloid dendritic cell antigen processing and presentation

HLA-DRB1 HLA-DRB3

7.68e-0531052GO:0002469
GeneOntologyBiologicalProcessregulation of translational fidelity

IARS1 LARS1 TARS2

1.17e-04191053GO:0006450
GeneOntologyBiologicalProcessMHC protein complex assembly

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.59e-04211053GO:0002396
GeneOntologyBiologicalProcessregulation of clathrin-dependent endocytosis

NEU3 DGKD SNAP91

1.59e-04211053GO:2000369
GeneOntologyBiologicalProcesspeptide antigen assembly with MHC protein complex

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.59e-04211053GO:0002501
GeneOntologyCellularComponentMHC class II protein complex

HLA-DRB1 HLA-DRB3 HLA-DRB4

8.18e-05171063GO:0042613
GeneOntologyCellularComponentclathrin-coated vesicle membrane

CLTCL1 HLA-DRB1 HLA-DRB3 HLA-DRB4 ATP6V1F SNAP91

1.04e-041471066GO:0030665
GeneOntologyCellularComponentautolysosome membrane

HLA-DRB1 HLA-DRB3

1.52e-0441062GO:0120281
GeneOntologyCellularComponentclathrin-coated endocytic vesicle

CLTCL1 HLA-DRB1 HLA-DRB3 HLA-DRB4 SNAP91

1.64e-041011065GO:0045334
GeneOntologyCellularComponentMHC protein complex

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.03e-04261063GO:0042611
GeneOntologyCellularComponentclathrin-coated endocytic vesicle membrane

HLA-DRB1 HLA-DRB3 HLA-DRB4 SNAP91

7.01e-04791064GO:0030669
GeneOntologyCellularComponentlumenal side of endoplasmic reticulum membrane

HLA-DRB1 HLA-DRB3 HLA-DRB4

7.37e-04351063GO:0098553
GeneOntologyCellularComponentpresynaptic active zone

IQSEC2 NRXN1 SNAP91 KCNMA1 UNC13C

7.63e-041411065GO:0048786
GeneOntologyCellularComponentcoated vesicle membrane

CLTCL1 HLA-DRB1 HLA-DRB3 HLA-DRB4 ATP6V1F SNAP91

8.01e-042151066GO:0030662
GeneOntologyCellularComponentspectrin-associated cytoskeleton

ANK1 SPTBN2

8.96e-0491062GO:0014731
GeneOntologyCellularComponentclathrin-coated vesicle

CLTCL1 HLA-DRB1 HLA-DRB3 HLA-DRB4 ATP6V1F SNAP91

1.32e-032371066GO:0030136
GeneOntologyCellularComponentparallel fiber to Purkinje cell synapse

SPTBN2 SNAP91 UNC13C

1.35e-03431063GO:0098688
GeneOntologyCellularComponentNSL complex

KANSL3 HCFC1

1.36e-03111062GO:0044545
GeneOntologyCellularComponentaminoacyl-tRNA synthetase multienzyme complex

IARS1 LARS1

1.63e-03121062GO:0017101
GeneOntologyCellularComponentlumenal side of membrane

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.86e-03481063GO:0098576
GeneOntologyCellularComponentplasma membrane protein complex

HLA-DRB1 HLA-DRB3 HLA-DRB4 INSRR CHRNB1 SNAP91 AHNAK KCNMA1 DLG3 LILRB5 GP1BA

2.12e-0378510611GO:0098797
GeneOntologyCellularComponentexcitatory synapse

SPTBN2 NRXN1 SNAP91 UNC13C

2.16e-031071064GO:0060076
GeneOntologyCellularComponentlysosomal membrane

HLA-DRB1 HLA-DRB3 HLA-DRB4 NEU3 ATP6V1F AHNAK ABCC10 WDR24

2.44e-034621068GO:0005765
GeneOntologyCellularComponentlytic vacuole membrane

HLA-DRB1 HLA-DRB3 HLA-DRB4 NEU3 ATP6V1F AHNAK ABCC10 WDR24

2.44e-034621068GO:0098852
GeneOntologyCellularComponentneuromuscular junction

CHRNB1 NRXN1 DLG3 UNC13C

2.55e-031121064GO:0031594
GeneOntologyCellularComponenttrans-Golgi network membrane

HLA-DRB1 HLA-DRB3 HLA-DRB4 VPS54

2.55e-031121064GO:0032588
DomainMHC_II_b_N

HLA-DRB1 HLA-DRB3 HLA-DRB4

9.20e-0681043PD000328
DomainMHC_II_b_N

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.38e-0591043IPR000353
DomainMHC_II_beta

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.38e-0591043SM00921
DomainMHC_II_beta

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.38e-0591043PF00969
DomainMHC_II_a/b_N

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.84e-05141043IPR014745
Domain-

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.84e-051410433.10.320.10
Domain-

STBD1 NTRK1 HLA-DRB1 HLA-DRB3 HLA-DRB4 INSRR IGDCC3 FNDC3A PLXNB2 CADM2 TGM1 LILRB5 HCFC1

7.94e-05663104132.60.40.10
DomainMamL-1

MAML1 MAML3

9.18e-0531042SM01275
DomainNeuroggenic_mastermind-like_N

MAML1 MAML3

9.18e-0531042IPR019082
DomainMamL-1

MAML1 MAML3

9.18e-0531042PF09596
DomainIg-like_fold

STBD1 NTRK1 HLA-DRB1 HLA-DRB3 HLA-DRB4 INSRR IGDCC3 FNDC3A PLXNB2 CADM2 TGM1 LILRB5 HCFC1

1.49e-0470610413IPR013783
DomainThiolase_acyl_enz_int_AS

ACAT1 SCP2

3.04e-0451042IPR020615
DomainThiolase_C

ACAT1 SCP2

4.54e-0461042PF02803
DomainAdcy_conserved_dom

ADCY4 ADCY2

4.54e-0461042IPR009398
DomainTHIOLASE_2

ACAT1 SCP2

4.54e-0461042PS00737
DomainITI_HC_C

ITIH1 ITIH6

4.54e-0461042IPR010600
DomainTHIOLASE_1

ACAT1 SCP2

4.54e-0461042PS00098
DomainTHIOLASE_3

ACAT1 SCP2

4.54e-0461042PS00099
DomainThiolase_N

ACAT1 SCP2

4.54e-0461042IPR020616
DomainThiolase_C

ACAT1 SCP2

4.54e-0461042IPR020617
DomainThiolase_CS

ACAT1 SCP2

4.54e-0461042IPR020613
DomainThiolase

ACAT1 SCP2

4.54e-0461042IPR002155
DomainDUF1053

ADCY4 ADCY2

4.54e-0461042PF06327
DomainVal/Leu/Ile-tRNA-synth_edit

IARS1 LARS1

4.54e-0461042IPR009008
DomainThiolase_N

ACAT1 SCP2

4.54e-0461042PF00108
DomainAnticodon_1

IARS1 LARS1

4.54e-0461042PF08264
DomainM/V/L/I-tRNA-synth_anticd-bd

IARS1 LARS1

4.54e-0461042IPR013155
Domain-

IARS1 LARS1

4.54e-04610423.90.740.10
DomainITI_HC_C

ITIH1 ITIH6

4.54e-0461042PF06668
Domainaa-tRNA-synth_Ia

IARS1 LARS1

6.33e-0471042IPR002300
DomaintRNA-synt_1

IARS1 LARS1

6.33e-0471042PF00133
Domain-

INTS6L COL22A1 ITIH1 ITIH6

7.74e-047410443.40.50.410
DomainAC_N

ADCY4 ADCY2

8.41e-0481042IPR032628
DomainAdcy

ADCY4 ADCY2

8.41e-0481042IPR030672
DomainVIT

ITIH1 ITIH6

8.41e-0481042PF08487
DomainVIT

ITIH1 ITIH6

8.41e-0481042SM00609
DomainAC_N

ADCY4 ADCY2

8.41e-0481042PF16214
DomainPH

IQSEC2 SPTBN2 TBC1D2 DGKD PREX2 PLEK2 AKAP13

9.33e-042781047SM00233
DomainPH_DOMAIN

IQSEC2 SPTBN2 TBC1D2 DGKD PREX2 PLEK2 AKAP13

9.53e-042791047PS50003
DomainPH_domain

IQSEC2 SPTBN2 TBC1D2 DGKD PREX2 PLEK2 AKAP13

9.73e-042801047IPR001849
DomainNHL_repeat_subgr

NHLRC2 TRIM32

1.08e-0391042IPR013017
DomainVWFA

INTS6L COL22A1 ITIH1 ITIH6

1.14e-03821044PS50234
DomainMHC_I/II-like_Ag-recog

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.23e-03381043IPR011162
DomainVWA

INTS6L COL22A1 ITIH1 ITIH6

1.24e-03841044SM00327
DomainVIT

ITIH1 ITIH6

1.34e-03101042PS51468
DomainNHL_repeat

NHLRC2 TRIM32

1.34e-03101042IPR001258
DomainVIT

ITIH1 ITIH6

1.34e-03101042IPR013694
DomainNHL

NHLRC2 TRIM32

1.34e-03101042PF01436
Domain-

ACAT1 SCP2

1.34e-031010423.40.47.10
DomainThiolase-like

ACAT1 SCP2

1.34e-03101042IPR016039
Domain-

IQSEC2 SPTBN2 TBC1D2 DGKD MTMR10 PREX2 PLEK2 AKAP13

1.54e-0339110482.30.29.30
Domain-

IARS1 LARS1

1.63e-031110421.10.730.10
DomainTyr_kinase_rcpt_2_CS

NTRK1 INSRR

1.63e-03111042IPR002011
DomainPH

SPTBN2 TBC1D2 DGKD PREX2 PLEK2 AKAP13

1.78e-032291046PF00169
DomainRECEPTOR_TYR_KIN_II

NTRK1 INSRR

1.95e-03121042PS00239
DomainVWF_A

INTS6L COL22A1 ITIH1 ITIH6

2.28e-03991044IPR002035
DomainNHL

NHLRC2 TRIM32

2.30e-03131042PS51125
DomainPH_dom-like

IQSEC2 SPTBN2 TBC1D2 DGKD MTMR10 PREX2 PLEK2 AKAP13

2.62e-034261048IPR011993
DomainNeurexin-like

CADM2 NRXN1

2.68e-03141042IPR003585
Domain4.1m

CADM2 NRXN1

2.68e-03141042SM00294
DomaintRNAsynth_Ia_anticodon-bd

IARS1 LARS1

3.08e-03151042IPR009080
DomainC1-set

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.39e-03541043PF07654
DomainIGc1

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.75e-03561043SM00407
DomainVWA

COL22A1 ITIH1 ITIH6

3.75e-03561043PF00092
DomainFN3

KIAA0319L INSRR IGDCC3 FNDC3A HCFC1

3.77e-031851045SM00060
DomainA/G_cyclase_CS

ADCY4 ADCY2

3.95e-03171042IPR018297
DomainIg/MHC_CS

HLA-DRB1 HLA-DRB3 HLA-DRB4

4.14e-03581043IPR003006
DomainIg_C1-set

HLA-DRB1 HLA-DRB3 HLA-DRB4

4.14e-03581043IPR003597
Domainaa-tRNA-synth_I_CS

IARS1 LARS1

4.43e-03181042IPR001412
Domain-

ADCY4 ADCY2

4.43e-031810423.30.70.1230
DomainNucleotide_cyclase

ADCY4 ADCY2

4.43e-03181042IPR029787
DomainIG_MHC

HLA-DRB1 HLA-DRB3 HLA-DRB4

4.56e-03601043PS00290
DomainGuanylate_cyc

ADCY4 ADCY2

4.94e-03191042PF00211
DomainGUANYLATE_CYCLASE_2

ADCY4 ADCY2

4.94e-03191042PS50125
DomainA/G_cyclase

ADCY4 ADCY2

4.94e-03191042IPR001054
DomainGUANYLATE_CYCLASE_1

ADCY4 ADCY2

4.94e-03191042PS00452
DomainCYCc

ADCY4 ADCY2

4.94e-03191042SM00044
DomainAA_TRNA_LIGASE_I

IARS1 LARS1

4.94e-03191042PS00178
DomainZF_DAG_PE_1

DGKD AKAP13 UNC13C

5.46e-03641043PS00479
DomainZF_DAG_PE_2

DGKD AKAP13 UNC13C

5.46e-03641043PS50081
PathwayBIOCARTA_BBCELL_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.71e-0511793M22030
PathwayBIOCARTA_EOSINOPHILS_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.71e-0511793M22048
PathwayBIOCARTA_IL5_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

4.65e-0513793M18928
PathwayBIOCARTA_MHC_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.90e-0514793M22023
PathwayBIOCARTA_TCRA_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.90e-0514793M10765
PathwayBIOCARTA_BLYMPHOCYTE_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.90e-0514793M1473
PathwayKEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_NFY_MEDIATED_TRANSCRIPTION

HLA-DRB1 HLA-DRB3 HLA-DRB4

7.34e-0515793M47588
PathwayKEGG_MEDICUS_REFERENCE_ANTIGEN_PROCESSING_AND_PRESENTATION_BY_MHC_CLASS_II_MOLECULES

HLA-DRB1 HLA-DRB3 HLA-DRB4

7.34e-0515793M47604
PathwayBIOCARTA_ASBCELL_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

7.34e-0515793M7298
PathwayBIOCARTA_CSK_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.42e-0422793M6327
PathwayBIOCARTA_CTLA4_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.42e-0422793M1467
PathwayBIOCARTA_TH1TH2_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.77e-0423793M6705
PathwayREACTOME_PD_1_SIGNALING

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.02e-0428793M18810
PathwayBIOCARTA_INFLAM_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.57e-0429793M6910
PathwayKEGG_ASTHMA

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.17e-0430793M13950
PathwayREACTOME_NRCAM_INTERACTIONS

ANK1 DLG3

6.39e-047792M27378
PathwayKEGG_CELL_ADHESION_MOLECULES_CAMS

HLA-DRB1 HLA-DRB3 HLA-DRB4 NRXN1 GLG1

8.94e-04133795M16476
Pubmed

HLA-DR genotypes influence age at disease onset in children and juveniles with type 1 diabetes mellitus.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.91e-083108320371654
Pubmed

Association of HLA-DR3 and HLA-DR4 with sinonasal polyposis in Mexican Mestizos.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.91e-083108316815190
Pubmed

Polymorphisms in the SOD2 and HLA-DRB1 genes are associated with nonfamilial idiopathic dilated cardiomyopathy in Japanese.

HLA-DRB1 HLA-DRB4 SOD2

2.91e-083108310425186
Pubmed

Binding domain regulation of MHC class II molecule assembly, trafficking, fate, and function.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.91e-08310838775462
Pubmed

A male-specific increase in the HLA-DRB4 (DR53) frequency in high-risk and relapsed childhood ALL.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.91e-083108312008082
Pubmed

Allelic variation in the DR subregion of the human major histocompatibility complex.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.16e-07410833476943
Pubmed

HLA class II alleles in systemic sclerosis patients with anti-RNA polymerase I/III antibody: associations with subunit reactivities.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.16e-074108314677183
Pubmed

Human leukocyte antigen association in idiopathic thrombotic thrombocytopenic purpura: evidence for an immunogenetic link.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.16e-074108319922436
Pubmed

Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.16e-074108326740600
Pubmed

Association of HLA-DR and -DQ genes with narcolepsy in Koreans: comparison with two control groups, randomly selected subjects and DRB1*1501-DQB1*0602--positive subjects.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.16e-074108317002906
Pubmed

HLA-DRB alleles and systemic lupus erythematosus in Jamaicans.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.16e-074108312144077
Pubmed

Associations of human leukocyte antigen DRB with resistance or susceptibility to HIV-1 infection in the Pumwani Sex Worker Cohort.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.16e-074108318520346
Pubmed

HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.16e-074108315795121
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

IRF2BP2 TRPS1 MAML1 CHD8 UBN2 CIC KANSL3 YLPM1 HCFC1

1.68e-07268108933640491
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

NES ACAT1 IARS1 HNRNPM LARS1 DGKD CHD8 PLEK2 TGM1 FBXL18 TRIM32 FANCI AHNAK DDX18 PPP1R37 AKAP13 PHIP KPNB1

1.88e-0713531081829467282
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

SLF1 ACAT1 HNRNPM CHD8 ICE1 UBN2 CIC SNAP91 FANCI AHNAK DDX18 YLPM1 HCFC1 PHIP KPNB1

2.74e-079541081536373674
Pubmed

Antinuclear antibodies and HLA class II alleles in Jamaican patients with systemic lupus erythematosus.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.90e-075108317910142
Pubmed

Major histocompatibility complex class II molecules promote human immunodeficiency virus type 1 assembly and budding to late endosomal/multivesicular body compartments.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.90e-075108316973583
Pubmed

Genetic variability in HIV-1 gp120 affects interactions with HLA molecules and T cell receptor.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.90e-07510831970352
Pubmed

Cross-reactive cytotoxic T lymphocytes induced by V3 loop synthetic peptides from different strains of human immunodeficiency virus type 1.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.90e-07510837645219
Pubmed

A comparison of HLA-DR and -DQ allele and haplotype frequencies in Trinidadian populations of African, South Asian, and mixed ancestry.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.90e-075108312392858
Pubmed

Association between psoriasis vulgaris and MHC-DRB, -DQB genes as a contribution to disease diagnosis.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.90e-075108315908298
Pubmed

HLA-DQ8 and the HLA-DQ8-DR4 haplotype are positively associated with the hevein-specific IgE immune response in health care workers with latex allergy.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.90e-075108312209103
Pubmed

HLA-DQA is associated with abdominal aortic aneurysms in the Belgian population.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.90e-075108317182961
Pubmed

HLA-DRB4 as a genetic risk factor for Churg-Strauss syndrome.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.90e-075108317763415
Pubmed

NY-ESO-1 119-143 is a promiscuous major histocompatibility complex class II T-helper epitope recognized by Th1- and Th2-type tumor-reactive CD4+ T cells.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.90e-075108311782380
Pubmed

Expansion of monocytic myeloid-derived suppressor cells dampens T cell function in HIV-1-seropositive individuals.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.90e-075108323152536
Pubmed

HLA-DR-restricted peptides identified in the Nef protein can induce HIV type 1-specific IL-2/IFN-gamma-secreting CD4+ and CD4+ /CD8+ T cells in humans after lipopeptide vaccination.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.90e-075108317411376
Pubmed

Productive human immunodeficiency virus type 1 assembly takes place at the plasma membrane.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.90e-075108317507489
Pubmed

Competition of HLA-DR and a beta 2 domain peptide for HIV envelope glycoprotein gp120 binding to CD4.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.90e-07510837734415
Pubmed

Visual hallucinations and HLA class II antigens in cortical dementia.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.90e-075108320606439
Pubmed

HLA-DR and DQB1 gene polymorphism in the North-western Colombian population.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.90e-075108312144632
Pubmed

HIV-1 gag polyprotein rescues HLA-DR intracellular transport in a human CD4+ cell line.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.90e-075108312202216
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

CLTCL1 KIAA0319L MAML1 CHD8 ICE1 PLXNB2 CIC KANSL3 FANCI AHNAK ZNF500 AKAP13 HAS3 HCFC1 ABCC10 WDR24

3.18e-0711051081635748872
Pubmed

Frequency of concurrent autoimmune disorders in patients with autoimmune hepatitis: effect of age, gender, and genetic background.

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.78e-076108318223493
Pubmed

Long-range linkage on chromosome 6p of VEGF, FKBP5, HLA and TNF alleles associated with transplant rejection.

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.78e-076108319233472
Pubmed

Association of immune responses to mycobacterium tuberculosis peptide antigens with host genetic factors.

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.78e-076108317153701
Pubmed

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.78e-076108318305173
Pubmed

HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma.

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.78e-076108315902698
Pubmed

Sequence analysis of HLA class II genes from insulin-dependent diabetic individuals.

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.78e-07610833372263
Pubmed

HLA risk markers for chronic myelogenous leukemia in Eastern Canada.

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.78e-076108319235017
Pubmed

A comparison of molecular HLA-DR and DQ allele profiles forming DR51-, DR52-, and DR53-related haplotypes in five ethnic Thai populations from mainland southeast Asia.

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.78e-076108311082517
Pubmed

Complete coding sequences and haplotypic associations of HLA-B*0707, -B*1524, -B*4405, -B*4802, -DRB1*0409, -DRB1*0411, -DRB1*1115, -DRB1*1305, and the novel allele -DRB1*0709. Group-specific amplification of cDNA from DRB1 alleles associated to DRB3 and DRB4.

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.78e-076108315896200
Pubmed

HLA class II DNA typing in a large series of European patients with systemic lupus erythematosus: correlations with clinical and autoantibody subsets.

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.78e-076108311997714
Pubmed

HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.78e-076108314508706
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

IRF2BP2 ANK1 IARS1 TRPS1 TBC1D2 CHD8 LOXL2 AHNAK KPNB1

1.01e-06332108937433992
Pubmed

Anti-cofactor autoantibodies in systemic lupus erythematosus: prevalence, clinical and HLA class II associations.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.01e-067108318569076
Pubmed

The HIV core protein p24 inhibits interferon-gamma-induced increase of HLA-DR and cytochrome b heavy chain mRNA levels in the human monocyte-like cell line THP1.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.01e-06710831905983
Pubmed

Human macrophages accumulate HIV-1 particles in MHC II compartments.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.01e-067108312230470
Pubmed

[Human leukocyte antigen genes to genetic predisposition in diffuse panbronchiolitis].

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.01e-067108318846964
Pubmed

The impact of anti-HY responses on outcome in current and subsequent pregnancies of patients with recurrent pregnancy losses.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.01e-067108320307907
Pubmed

Association of HY-restricting HLA class II alleles with pregnancy outcome in patients with recurrent miscarriage subsequent to a firstborn boy.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.61e-068108319223392
Pubmed

Correlation between HLA and pityriasis rosea susceptibility in Brazilian blacks.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.61e-068108316405603
Pubmed

HLA-A, B, Cw, DRB1, DRB3/4/5, DQB1 in German patients suffering from rapidly progressive periodontitis (RPP) and adult periodontitis (AP).

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.61e-068108312296785
Pubmed

Human leukocyte antigen class I and class II allele frequencies and HIV-1 infection associations in a Chinese cohort.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.61e-068108317106278
Pubmed

Human plasmacytoid dendritic cells efficiently capture HIV-1 envelope glycoproteins via CD4 for antigen presentation.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.61e-068108323729440
Pubmed

Fusion of ubiquitin to HIV gag impairs human monocyte-derived dendritic cell maturation and reduces ability to induce gag T cell responses.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.41e-069108324505475
Pubmed

Major histocompatibility complex class-II molecules promote targeting of human immunodeficiency virus type 1 virions in late endosomes by enhancing internalization of nascent particles from the plasma membrane.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.41e-069108323170932
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

NES STBD1 MAML1 HLCS FNDC3A ATP6V1F ICE1 NHLRC2 CLMN YLPM1 AKAP13 HCFC1

3.09e-067331081234672954
Pubmed

Defining the membrane proteome of NK cells.

CLTCL1 IARS1 HLA-DRB1 HLA-DRB3 HNRNPM FNDC3A TBC1D10C GLG1 FANCI AHNAK DDX18 SCP2 AKAP13 HCFC1 KPNB1

3.37e-0611681081519946888
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

CPAMD8 MAPT TRPS1 VPS54 TARS2 UBN2 KANSL3 THRA CLMN LOXL2 KCNMA1 SCP2 AKAP13 PNPLA7 ALDH3B2 MAML3 INVS

3.42e-0614891081728611215
Pubmed

Cell organization, growth, and neural and cardiac development require αII-spectrin.

ANK1 MAPT SPTBN2

3.44e-0610108322159418
Pubmed

Differential effects of R5 and X4 human immunodeficiency virus type 1 infection on CD4+ cell proliferation and activation.

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.44e-0610108315784911
Pubmed

Roles of HLA-B, HLA-C and HLA-DPA1 incompatibilities in the outcome of unrelated stem-cell transplantation.

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.44e-0610108312956878
Pubmed

HIV-gp 160-induced T cell-dependent B cell differentiation. Role of T cell-B cell activation molecule and IL-6.

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.44e-061010838450224
Pubmed

Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART.

HLA-DRB1 HLA-DRB3 HLA-DRB4

4.72e-0611108321085635
Pubmed

Intracellular overexpression of HIV-1 Nef impairs differentiation and maturation of monocytic precursors towards dendritic cells.

HLA-DRB1 HLA-DRB3 HLA-DRB4

4.72e-0611108322808111
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

CLTCL1 IARS1 IQSEC2 SPTBN2 TRPS1 LARS1 TARS2 PLXNB2 TGM1 FANCI AHNAK ABCC10 GP1BA

6.15e-069251081328986522
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

NES ACAT1 SPTBN2 CHD8 FANCI AHNAK DDX18 YLPM1 HCFC1 PHIP KPNB1

6.25e-066531081122586326
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

CLTCL1 ACAT1 IARS1 HNRNPM LARS1 CHD8 NHLRC2 GLG1 AHNAK DDX18 AKAP13 KPNB1

8.18e-068071081230575818
Pubmed

Human transcription factor protein interaction networks.

IRF2BP2 SLF1 IARS1 TRPS1 LARS1 MAML1 CHD8 UBN2 MIER1 CIC KANSL3 SAMD11 DDX18 YLPM1 HCFC1 MNT

8.75e-0614291081635140242
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

NES IQSEC2 SPTBN2 HNRNPM CHD8 UBN2 ITIH1 NRXN1 SNAP91 YLPM1 KCNMA1 DLG3 KPNB1

9.44e-069631081328671696
Pubmed

Two distinct subtypes of the HLA-DRw12 haplotypes in the Japanese population detected by nucleotide sequence analysis and oligonucleotide genotyping.

HLA-DRB1 HLA-DRB4

9.55e-06210822592019
Pubmed

Paediatric celiac patients carrying the HLA-DR7-DQ2 and HLA-DR3-DQ2 haplotypes display small clinical differences.

HLA-DRB1 HLA-DRB3

9.55e-062108224628273
Pubmed

Structural comparison of the genes of two HLA-DR supertypic groups: the loci encoding DRw52 and DRw53 are not truly allelic.

HLA-DRB1 HLA-DRB4

9.55e-06210823596674
Pubmed

Mutations and selection in the generation of class II histocompatibility antigen polymorphism.

HLA-DRB1 HLA-DRB3

9.55e-06210826589154
Pubmed

DRB1*03 diversity and DRB3 associations in five major population groups in the United States.

HLA-DRB1 HLA-DRB3

9.55e-062108211872240
Pubmed

Structural organization of the DR subregion of the human major histocompatibility complex.

HLA-DRB1 HLA-DRB4

9.55e-06210823860851
Pubmed

A cellular and functional split in the DRw8 haplotype is due to a single amino acid replacement (DR beta ser 57- asp 57).

HLA-DRB1 HLA-DRB3

9.55e-06210822497068
Pubmed

HLA-DR4 as a risk allele for autism acting in mothers of probands possibly during pregnancy.

HLA-DRB1 HLA-DRB4

9.55e-062108219487610
Pubmed

HLA-DR association in papillary thyroid carcinoma.

HLA-DRB1 HLA-DRB4

9.55e-062108220164547
Pubmed

β-III spectrin underpins ankyrin R function in Purkinje cell dendritic trees: protein complex critical for sodium channel activity is impaired by SCA5-associated mutations.

ANK1 SPTBN2

9.55e-062108224603075
Pubmed

The conundrum of HLA-DRB1*14:01/*14:54 and HLA-DRB3*02:01/*02:02 mismatches in unrelated hematopoietic SCT.

HLA-DRB1 HLA-DRB3

9.55e-062108220972469
Pubmed

Identification of a novel HLA-DRB1 allele (HLA-DRB1*111902*).

HLA-DRB1 HLA-DRB4

9.55e-062108215982264
Pubmed

The TrkAIII oncoprotein inhibits mitochondrial free radical ROS-induced death of SH-SY5Y neuroblastoma cells by augmenting SOD2 expression and activity at the mitochondria, within the context of a tumour stem cell-like phenotype.

NTRK1 SOD2

9.55e-062108224736663
Pubmed

Development of a new HLA-DRB real-time PCR typing method.

HLA-DRB1 HLA-DRB3

9.55e-062108215620466
Pubmed

Sequence and evolution of HLA-DR7- and -DRw53-associated beta-chain genes.

HLA-DRB3 HLA-DRB4

9.55e-06210823110774
Pubmed

Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study.

HLA-DRB1 HLA-DRB4

9.55e-062108215140072
Pubmed

Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles.

HLA-DRB1 HLA-DRB3

9.55e-062108216320316
Pubmed

Description of two new HLA-DRB alleles (DRB1*0310 and DRB3*01012) found in a Spanish infant.

HLA-DRB1 HLA-DRB3

9.55e-06210829234492
Pubmed

T cell receptors recognizing type II collagen in HLA-DR-transgenic mice characterized by highly restricted V beta usage.

HLA-DRB1 HLA-DRB4

9.55e-062108215188377
Pubmed

Tracking antigen-specific T-cells during clinical tolerance induction in humans.

HLA-DRB1 HLA-DRB3

9.55e-062108220543955
Pubmed

Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis.

HLA-DRB1 HLA-DRB3

9.55e-062108216200610
Pubmed

HLA-DRB1*15:01 and HLA-DRB3*02:02 in PLA2R-Related Membranous Nephropathy.

HLA-DRB1 HLA-DRB3

9.55e-062108228028136
Pubmed

HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans.

HLA-DRB1 HLA-DRB3

9.55e-062108215041167
Pubmed

The unusual DRB1*08:01 haplotype carrying DRB3*02:02 confirmed in a Dutch family.

HLA-DRB1 HLA-DRB3

9.55e-062108223742216
Pubmed

Compound heterozygosity of HLA-DRB3*01:01 and HLA-DRB4*01:01 as a potential predictor of fetal neonatal alloimmune thrombocytopenia.

HLA-DRB3 HLA-DRB4

9.55e-062108222671039
Pubmed

Mitochondrial oxidative stress causes hyperphosphorylation of tau.

MAPT SOD2

9.55e-062108217579710
Pubmed

Regulation and immunohistochemical localization of betagamma-stimulated adenylyl cyclases in mouse hippocampus.

ADCY4 ADCY2

9.55e-06210829870949
Pubmed

Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy.

HLA-DRB1 HLA-DRB3

9.55e-062108230282837
InteractionALDOC interactions

MAPT NTRK1 NHLRC2 LOXL2 UMPS HCFC1 SOD2

9.23e-061401067int:ALDOC
InteractionPKM interactions

ACAT1 MAPT NTRK1 HLA-DRB1 HLA-DRB3 HLA-DRB4 FNDC3A CIC NRXN1 LOXL2 SOD2 INVS

1.19e-0549710612int:PKM
InteractionATP1B1 interactions

ACAT1 MAPT NTRK1 HLA-DRB1 HLA-DRB3 HLA-DRB4 KIAA0319L

2.90e-051671067int:ATP1B1
InteractionTNIK interactions

NES MAPT IQSEC2 SPTBN2 CHD8 UBN2 INTS10 SNAP91 KCNMA1 DLG3

3.30e-0538110610int:TNIK
InteractionMEX3A interactions

IRF2BP2 ANK1 IARS1 NTRK1 TRPS1 TBC1D2 CHD8 LOXL2 AHNAK KPNB1

3.52e-0538410610int:MEX3A
InteractionNT5C2 interactions

MAPT NTRK1 GLYCTK NHLRC2 PREX2 KPNB1

3.58e-051171066int:NT5C2
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

MAPT VPS54 PREX2 YLPM1 PPP1R37 DLG3 HCFC1

6.95e-06181717694
GeneFamilyC1-set domain containing

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.97e-0442713591
GeneFamilyAdenylate cyclases|Deafness associated genes

ADCY4 ADCY2

6.70e-041071253
GeneFamilyHistocompatibility complex|C1-set domain containing

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.85e-0444713588
GeneFamilyX-linked mental retardation|Angiotensin receptors

IQSEC2 DLG3 HCFC1

1.18e-0353713103
GeneFamilyIntegrator complex

INTS6L INTS10

1.54e-03157121366
GeneFamilyAminoacyl tRNA synthetases, Class I

IARS1 LARS1

2.49e-0319712131
CoexpressionNAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_DN

HLA-DRB1 HLA-DRB3 HLA-DRB4 ICE1 CLMN AHNAK YLPM1 AKAP13 MNT KPNB1

5.65e-0639910710M40939
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLF1 ACRBP NTRK1 HLCS ADCK2 INTS10 LOXL2

1.30e-071631067953a7db7e90a913e81002d2141fbbd5f1fdf2197
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACRBP NTRK1 HLCS LOXL2 MAML3 ABCC10 KPNB1

1.30e-071631067132aece9c79499b4bb3c2bde68d3d7202e1d8772
ToppCellControl-NK_activated|Control / Disease condition and Cell class

ADCY4 CLTCL1 USP29 IGDCC3 KCNMA1 HAS3

4.15e-0711910660d0bab03d56e269c6e637b0bbeffe9d1491dfc33
ToppCellCOVID-19-Heart-CM_5_(RYR2-)|COVID-19 / Disease (COVID-19 only), tissue and cell type

CLTCL1 CAND2 MAPT ADCY2 CHRNB1 UNC13C

1.27e-061441066f92e03dd784e31a9e5dbd4f4c3a6517ea19210cf
ToppCellCOVID-19-Heart-CM_5_(RYR2-)|Heart / Disease (COVID-19 only), tissue and cell type

CLTCL1 MAPT ADCY2 CHRNB1 UNC13C ITIH6

1.95e-061551066d7e26696fd9c0a759524f331243db43059b33ed9
ToppCellwk_15-18-Hematologic-Meg-ery-Platelet|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ANK1 ACRBP NTRK1 INSRR DGKD GP1BA

2.34e-061601066768f3cefc3ad4cda229e598cce8bde574cf64bb2
ToppCelldroplet-Marrow-BM-1m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK1 IQSEC2 HLCS CIC PREX2 AHNAK

3.10e-0616810662e88d9cb7c80a4656fab290db8b45a5a0599d769
ToppCelldroplet-Marrow-nan-18m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAND2 IQSEC2 NEU3 TARS2 PLXNB2 INVS

3.80e-06174106655cc8300489d11322724159ec7d0e1d32a702e91
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CPAMD8 NTRK1 SPTBN2 INSRR ATP6V1F PLEK2

6.49e-061911066feec8617678b778475747ad406c80231e07fd6f7
ToppCellTracheal|World / Cell types per location group and 10X technology with lineage, and cell group designations

TRPS1 HLCS GOLM1 ADCY2 RAVER2 KCNMA1

8.44e-062001066682960e28542a3d6c119047cd0131941932cfdea
ToppCellfacs-Heart-Unknown-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFCAB5 IGDCC3 PLEK2 SNAP91 KCNMA1

2.21e-0514110654aa4b3476dc5abefbd348353cfe711cd5fe3d52f
ToppCellfacs-Heart-Unknown-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFCAB5 IGDCC3 PLEK2 SNAP91 KCNMA1

2.21e-051411065e40c6f1b7fbaa46b3eaa55f1b37ef360b04370a8
ToppCellAdult-Immune-enucleated_erythrocyte-D175|Adult / Lineage, Cell type, age group and donor

SPTBN2 ADCK2 SLC39A12 NRXN1 TRIM32

3.17e-051521065530d5427d8617dcb223d807b73abee0ef89285f3
ToppCell368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

EFCAB5 ANK1 NTRK1 CADM2 THRA

3.17e-051521065ca23261d8ef263cc697b8d7e7cb2afec8bc564f2
ToppCellprimary_visual_cortex-Non-neuronal-astrocyte|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PREX2 SLC39A12 CLMN PNPLA7 KIAA2012

3.27e-05153106595b28c5bd10ffb74c0993ebd565038b9818e4bd2
ToppCellprimary_visual_cortex-Non-neuronal-astrocyte-Astro|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PREX2 SLC39A12 CLMN PNPLA7 KIAA2012

3.27e-051531065b09f8def40a1ea56722f3398f61a036667b61cd9
ToppCellprimary_visual_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PREX2 SLC39A12 CLMN PNPLA7 KIAA2012

3.27e-0515310653ab9d55b3db51715c1d61eca142384195ce4b54f
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

HLCS FANCI SCP2 ABCC10

3.45e-05771064ebb1a537751739232820a60f88911877fc683855
ToppCelldroplet-Liver-Hepatocytes-18m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAPT MIER1 FBXL18 NRXN1 RAVER2

3.59e-051561065d72c2f5f72d269e29033f8728d924e0d4c8772c7
ToppCell368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

EFCAB5 ANK1 PAMR1 NTRK1 CADM2

4.05e-05160106519105debef96ea0c267d6a1d332303ec668ae47e
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

KIAA0319L NHLRC2 AHNAK SCP2 AKAP13

4.30e-051621065810881210e015c788814e4fe8d7a24c929cf2621
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL22A1 ADCY2 CADM2 NRXN1 SNAP91

4.56e-051641065be49af6335f2505065cde2cb9800e4a5516811b1
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANKRD13B STBD1 FAR2 FANCI DLG3

5.26e-051691065481e611b5fface58f1630f206c0b04fb54e24011
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL22A1 ADCY2 CADM2 NRXN1 SNAP91

5.26e-051691065b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCellCOVID-19-Heart-T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

ANK1 ADCY2 CADM2 NRXN1 UNC13C

5.56e-051711065b2e753e811a7639956994609f73efcdb62d04f82
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANKRD13B NES NEU3 CADM2 NRXN1

7.09e-051801065c72f15763ba707189e29c85db533557f01c7fdb1
ToppCellPND07-Epithelial-Epithelial_Airway-Basal-Basal|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SPTBN2 PLEK2 TGM1 LOXL2 ALDH3B2

7.27e-0518110656b43dcaeeb02ad5900772b6f16f1581847050e38
ToppCellPND07-Epithelial-Epithelial_Airway-Basal|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SPTBN2 PLEK2 TGM1 LOXL2 ALDH3B2

7.27e-051811065f50561fdacfb83ba85fe6476e7cbc2bad1ebc826
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

COL22A1 ADCY2 CADM2 NRXN1 SNAP91

7.47e-05182106557bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANKRD13B CIC THRA FBXL18 SERGEF

7.86e-051841065a6dee97ee4ef9d89e11d17339e0dadaea1210ce5
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK1 COL22A1 CADM2 NRXN1 UNC13C

7.86e-0518410652cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK1 COL22A1 CADM2 NRXN1 UNC13C

7.86e-051841065ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK1 COL22A1 CADM2 NRXN1 UNC13C

7.86e-0518410652b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ACAT1 NTRK1 INSRR ATP6V1F PLEK2

8.27e-051861065c2b65b8345487710704c3eb043e9bef2e2b1ff27
ToppCelldroplet-Limb_Muscle-nan-21m-Mesenchymal-skeletal_muscle_satellite_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STBD1 ANK1 CADM2 CHRNB1 CLMN

8.27e-0518610651cbb1a1c4f0f6078e9c7b4e0dc93d6b6de7e57db
ToppCellmild-unassigned|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TGM1 FBXL18 YLPM1 HAS3 WDR24

8.27e-0518610655b2e1a58916f392fa1156bf9210df528775248ff
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL22A1 ADCY2 CADM2 NRXN1 SNAP91

8.27e-051861065b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN2 PLEK2 TBC1D10C FBXL18 WDR24

8.48e-05187106522fd1959879705a8c1128faa9de66696c4e0b7e3
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN2 PLEK2 TBC1D10C FBXL18 WDR24

8.48e-0518710655fae538de481367cf6d9a2d52190d77b99f6922c
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PAMR1 PREX2 SLC39A12 SAMD11 AHNAK

8.48e-051871065401be371b32066db926de3415bb4ce9465749dc3
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN2 PLEK2 TBC1D10C FBXL18 WDR24

8.48e-0518710650526c0a818cf28fd5b6ff65fe260e3c3a4a98a2a
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IRF2BP2 INSRR UBN2 NRXN1 AKAP13

8.70e-051881065a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NES MAPT ADCY2 NRXN1 LOXL2

8.70e-051881065a906c29e3fda22eecfec3e5cac706c417bf2b7a4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NES CPAMD8 ADCY4 PREX2 FAR2

8.92e-05189106512b6f1c3bf526b90e112374bf937701f645c5780
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ACAT1 NTRK1 INSRR ATP6V1F PLEK2

8.92e-0518910651fd763c4e9904e866586a506ee7b0b285170481d
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NES MAPT ADCY2 NRXN1 LOXL2

9.14e-051901065951e067d14412db67dc3babcdf61e41717d7b429
ToppCell10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-naive_B_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

HLA-DRB1 DGKD SP110 TBC1D10C AKAP13

9.37e-051911065a073d58154c801ec499fd969f42b7f1ee7f15d79
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PREX2 CADM2 SLC39A12 NRXN1 PNPLA7

9.60e-051921065261211a86e6f63b09c2ddce1d2d9257d311f1770
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_macrophage|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HLA-DRB1 IQSEC2 ATP6V1F PLXNB2 AHNAK

1.03e-0419510654e9513a7ea69fa9fc8e9ff2da8ef3f44e8fdc70d
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HLA-DRB1 IQSEC2 ATP6V1F PLXNB2 AHNAK

1.03e-041951065a25a342380e258b784227f7298f609ccaa1f9ce7
ToppCell15-Trachea-Epithelial-Epithelial|Trachea / Age, Tissue, Lineage and Cell class

NES MAPT IGDCC3 CADM2 NRXN1

1.03e-0419510659e9283a397f56732a0a5f2e2527f154d4c2dd56a
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-skeletal_muscle_satellite_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK1 MAPT ADCY2 CHRNB1 CLMN

1.06e-0419610653dc6394c5de1f875a19ad0e8799827fad29f8f02
ToppCellfacs-Brain_Non-Myeloid-Cortex|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAPT CADM2 SLC39A12 NRXN1 CLMN

1.06e-041961065256fe9bc0815f66a9afe11ba3507ef1372b52fd3
ToppCellCOVID-19-Myeloid-Transitioning_MDM|COVID-19 / group, cell type (main and fine annotations)

TRPS1 FNDC3A CLMN KCNMA1 MAML3

1.06e-0419610654929cfed1f150c1fde4d79cb49895c2ea467a18f
ToppCellControl-Control-Lymphocyte-T/NK-NK_activated|Control / Disease, condition lineage and cell class

EFCAB5 ADCY4 AHNAK DLG3 HAS3

1.11e-04198106576d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCellproximal-Epithelial-Neuroendocrine|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

IGDCC3 ITIH1 CADM2 NRXN1 SNAP91

1.11e-0419810655dea6078488d584513c0bdbf5bba54877310b54a
ToppCellproximal-Epithelial-Neuroendocrine-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

IGDCC3 ITIH1 CADM2 NRXN1 SNAP91

1.11e-04198106500ccf3020667cf2130bc354b441b65c0b1b0e862
ToppCellproximal-3-Epithelial-Neuroendocrine|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

IGDCC3 ITIH1 CADM2 NRXN1 SNAP91

1.11e-041981065a6bc043faf68468d46bac441cf7447c236c7bae4
ToppCelltumor_Lung-Myeloid_cells-mo-Mac|tumor_Lung / Location, Cell class and cell subclass

HLA-DRB1 ATP6V1F KCNMA1 LILRB5 SOD2

1.14e-04199106577d46acf655029eab23471dc4c4a1b0832b24306
ToppCellTracheal-10x3prime_v2-Stromal-Schwann-Schwann_nonmyelinating|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

EFCAB5 CAND2 CADM2 NRXN1 FANCI

1.14e-041991065a92718a3f1153b8d2196fd343ed5bc0ebc98cad7
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

TRPS1 HLCS VPS54 KCNMA1 MAML3

1.14e-04199106594b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellTracheal-10x3prime_v2-Stromal-Schwann|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

EFCAB5 CAND2 CADM2 NRXN1 FANCI

1.14e-0419910658dc65662c3ca1db2ba0091332f0658abc0afc5de
ToppCellcontrol-Myeloid-CD14_Monocytes_1|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

IRF2BP2 HLA-DRB1 ATP6V1F PLXNB2 AHNAK

1.14e-0419910658c14237c3da91d1a4878df489a495408a1e83883
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HLA-DRB1 TRPS1 SLC39A12 KCNMA1 LILRB5

1.16e-042001065179afc4bee7a2fd85a3b5dadf32544a63807c164
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DGKD GOLM1 CLMN KCNMA1 PNPLA7

1.16e-042001065c450a15e21fa72d071ed6e3b9f22de557a0f3cea
ToppCellTracheal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HLCS GOLM1 CLMN RAVER2 MAML3

1.16e-042001065d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HLCS GOLM1 RAVER2 KCNMA1 MAML3

1.16e-0420010650eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCellControl_saline-Endothelial-Endothelial-Vein|Control_saline / Treatment groups by lineage, cell group, cell type

ADCY4 IGDCC3 PREX2 FAR2 UNC13C

1.16e-042001065e5f876910bc8cb390d9b46a48d9b6d4d57235551
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Il33_(Il33)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

COL22A1 TBC1D10C FANCI LOXL2

1.25e-041071064d446ffbe93cd49669f1cf91411aae07cc15d9e2a
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Il33_(Il33)|Hippocampus / BrainAtlas - Mouse McCarroll V32

COL22A1 TBC1D10C FANCI LOXL2

1.25e-0410710645c9e745d0b08a4aa1f3a93f9cc094fac57061a30
ToppCellPBMC-Control-Lymphocyte-T/NK-NK_cell-NK_activated|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ADCY4 USP29 IGDCC3 HAS3

1.82e-0411810645f72022f4be3fb7ccec86dc05d37572833028886
ToppCellPBMC-Control-Lymphocyte-T/NK-NK_cell-NK_activated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ADCY4 USP29 IGDCC3 HAS3

1.82e-041181064053c0986051e36fdc4c48b8067c137b6299b2f1b
ToppCellControl-Lymphoid_T/NK-NK_activated|Control / Disease group, lineage and cell class

ADCY4 USP29 IGDCC3 HAS3

1.88e-041191064a258d91ac90d4174b6f203d7f96ba6e57c6003e7
ToppCellPBMC-Control-Lymphocyte-T/NK-NK_cell-NK_activated|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADCY4 USP29 IGDCC3 HAS3

1.88e-04119106428d6b0e9dda2fe4ca94ae9b95b7261618d0d9877
ToppCellPBMC-Control-Lymphocyte-T/NK-NK_cell-NK_activated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADCY4 USP29 IGDCC3 HAS3

1.88e-0411910640fdd5b093ac20a4bda0f7b623808eb3ad0bf68e2
DrugMephenesin [59-47-2]; Down 200; 22uM; PC3; HT_HG-U133A

MAPT PLXNB2 CHRNB1 YLPM1 DLG3 AKAP13 ABCC10 SOD2

3.98e-0619710687374_DN
Drugepicholesterol

ALLC ADCY4 CLTCL1 ACAT1 NEU3 ADCY2 CHRNB1 INTS10 THRA TRIM32 KCNMA1 SCP2 SOD2

8.21e-0663610613CID000000304
DrugCAS 66104-23-2

ADCY4 ADCY2 TRIM32 LOXL2 SOD2

1.13e-05631065CID000004745
DrugDMPD

TGM1 KCNMA1 MNT SOD2

1.64e-05331064CID000007472
DrugAC1MPJID

ADCY4 HLA-DRB1 FNDC3A VPS54 ADCY2 TGM1

1.82e-051171066CID003386230
Drugazaleucine

IARS1 LARS1 THRA

2.09e-05121063CID000160768
DrugNSC636979

IARS1 LARS1

2.15e-0521062CID000367344
DrugGalanthamine hydrobromide [1953-04-4]; Down 200; 10.8uM; PC3; HT_HG-U133A

CLTCL1 MAPT SPTBN2 KANSL3 FBXL18 SERGEF HCFC1

3.39e-0519310674186_DN
DrugSulfamethazine sodium salt [1981-58-4]; Up 200; 13.4uM; PC3; HT_HG-U133A

CLTCL1 IQSEC2 TBC1D2 MAML1 CHRNB1 GLG1 KCNMA1

3.39e-0519310674322_UP
DrugAzaguanine-8 [134-58-7]; Down 200; 26.2uM; MCF7; HT_HG-U133A

LARS1 DGKD CLMN GLG1 YLPM1 DLG3 HCFC1

3.50e-0519410671670_DN
DrugIndoprofen [31842-01-0]; Down 200; 14.2uM; PC3; HT_HG-U133A

SPTBN2 KIAA0319L HLCS KANSL3 THRA KCNMA1 HCFC1

3.50e-0519410674249_DN
DrugPirenzepine dihydrochloride [29868-97-1]; Down 200; 9.4uM; MCF7; HT_HG-U133A

NES ADCK2 FNDC3A FBXL18 GLG1 HCFC1 ABCC10

3.74e-0519610677226_DN
DrugBenperidol [2062-84-2]; Down 200; 10.4uM; PC3; HT_HG-U133A

CLTCL1 MAPT KIAA0319L KANSL3 THRA SERGEF HCFC1

3.74e-0519610674196_DN
DrugStreptomycin sulfate [3810-74-0]; Down 200; 2.8uM; MCF7; HT_HG-U133A

KIAA0319L ADCK2 CLMN YLPM1 ZNF500 AKAP13 HCFC1

3.86e-0519710677194_DN
DrugTheobromine [83-67-0]; Down 200; 22.2uM; MCF7; HT_HG-U133A

SPTBN2 KIAA0319L HLCS DGKD FBXL18 GLG1 DLG3

3.86e-0519710673334_DN
DrugTiletamine hydrochloride; Up 200; 15.4uM; MCF7; HT_HG-U133A

TBC1D2 ADCK2 THRA RAVER2 KCNMA1 AKAP13 HCFC1

3.99e-0519810676013_UP
DrugCyclacillin [3485-14-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A

SPTBN2 TBC1D2 HLCS CIC THRA SERGEF HCFC1

3.99e-0519810673882_DN
DrugPrimidone [125-33-7]; Up 200; 18.4uM; MCF7; HT_HG-U133A

ALLC SPTBN2 NEU3 ADCY2 CHRNB1 THRA KCNMA1

4.12e-0519910673402_UP
Diseaseneutrophil count

NES CPAMD8 MAPT NTRK1 HLA-DRB1 HLA-DRB3 IQSEC2 MAML1 NHLRC2 TARS2 CIC PREX2 SLC39A12 THRA GLG1 SERGEF AKAP13 UNC13C

1.75e-06138210518EFO_0004833
Diseaseaspirin-induced respiratory disease (is_implicated_in)

HLA-DRB1 HLA-DRB3 HLA-DRB4

7.08e-06111053DOID:0080822 (is_implicated_in)
Diseasepolyneuropathy (is_implicated_in)

HLA-DRB1 SOD2

7.49e-0541052DOID:1389 (is_implicated_in)
Diseaseamyotrophic lateral sclerosis type 1 (implicated_via_orthology)

VPS54 SOD2

7.49e-0541052DOID:0060193 (implicated_via_orthology)
Diseaseinfectious mononucleosis (is_implicated_in)

HLA-DRB1 SOD2

7.49e-0541052DOID:8568 (is_implicated_in)
Diseasevery low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

C5orf67 HLA-DRB1 TRPS1 NHLRC2 INTS10 LILRB5 KPNB1

8.43e-052911057EFO_0008317, EFO_0020946
Diseasetotal lipids in small VLDL

C5orf67 HLA-DRB1 TRPS1 INTS10

9.77e-05671054EFO_0022148
DiseaseAlzheimer's disease (is_implicated_in)

MAPT NTRK1 HLA-DRB1 KCNMA1 SOD2

1.12e-041321055DOID:10652 (is_implicated_in)
Diseasephospholipids in large HDL measurement

C5orf67 HLA-DRB1 TRPS1 INTS10

1.36e-04731054EFO_0022190
Diseasetotal lipids in large HDL

C5orf67 HLA-DRB1 TRPS1 INTS10

1.44e-04741054EFO_0022189
Diseasecholesteryl ester measurement, very low density lipoprotein cholesterol measurement

C5orf67 HLA-DRB1 TRPS1 NHLRC2 INTS10 KPNB1

1.58e-042251056EFO_0008317, EFO_0010351
DiseaseCREST Syndrome

HLA-DRB1 KIAA0319L

1.86e-0461052C0206138
Diseaseextranodal nasal NK/T cell lymphoma

HLA-DRB1 HLA-DRB3

1.86e-0461052MONDO_0019472
DiseaseScleroderma, Limited

HLA-DRB1 KIAA0319L

1.86e-0461052C0748540
Diseasecholesterol in large HDL measurement

C5orf67 HLA-DRB1 TRPS1 INTS10

1.95e-04801054EFO_0021900
DiseaseMental Retardation, X-Linked 1

IQSEC2 DLG3 HCFC1

2.01e-04321053C2931498
DiseaseCongenital Pain Insensitivity

CLTCL1 NTRK1

2.60e-0471052C0002768
DiseaseAlzheimer disease, educational attainment

MAPT HLA-DRB1 CADM2 NRXN1 PPP1R37 MAML3

2.61e-042471056EFO_0011015, MONDO_0004975
Diseaseretinal detachment, retinal break

CPAMD8 MAPT COL22A1

2.64e-04351053EFO_0005773, EFO_0010698
DiseaseBipolar Disorder

NTRK1 HLA-DRB1 HLA-DRB4 ADCY2 ITIH1 NRXN1 DLG3 SOD2

3.12e-044771058C0005586
DiseaseSarcoidosis

HLA-DRB1 SOD2

3.46e-0481052C0036202
DiseaseHereditary spherocytosis

ANK1 UMPS

3.46e-0481052C0037889
Diseaseoptic neuritis (is_implicated_in)

HLA-DRB1 SOD2

3.46e-0481052DOID:1210 (is_implicated_in)
Diseasehigh density lipoprotein particle size measurement

C5orf67 HLA-DRB1 TRPS1 NHLRC2 INTS10

3.63e-041701055EFO_0008592
Diseaseaspartate aminotransferase measurement

C5orf67 MAPT HLA-DRB1 HLA-DRB3 NHLRC2 ITIH1 SLC39A12 AKAP13 KIAA2012 LILRB5 PHIP

3.81e-0490410511EFO_0004736
Diseasechylomicron measurement, triglyceride measurement, very low density lipoprotein cholesterol measurement

C5orf67 HLA-DRB1 INTS10 SOD2

3.91e-04961054EFO_0004530, EFO_0008317, EFO_0008596
Diseasenon-syndromic X-linked intellectual disability (implicated_via_orthology)

IQSEC2 DLG3

4.44e-0491052DOID:0050776 (implicated_via_orthology)
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

C5orf67 HLA-DRB1 SOD2

4.54e-04421053EFO_0008317, EFO_0008596, EFO_0020945
Diseasewaist-hip ratio, high density lipoprotein cholesterol measurement

C5orf67 NHLRC2

5.54e-04101052EFO_0004343, EFO_0004612
Diseaseapolipoprotein A 1 measurement, apolipoprotein B measurement

C5orf67 TRPS1 NHLRC2 KPNB1

5.90e-041071054EFO_0004614, EFO_0004615
Diseasecortical thickness

ANKRD13B IRF2BP2 CPAMD8 C5orf67 MAPT SPTBN2 TRPS1 FAR2 SNAP91 YLPM1 HAS3 ABCC10

6.06e-04111310512EFO_0004840
Diseasefree cholesterol in small VLDL measurement

HLA-DRB1 TRPS1 KPNB1

6.34e-04471053EFO_0022272
DiseaseMacrocephaly

CHD8 THRA

6.76e-04111052C0221355
Diseasetriglyceride measurement, intermediate density lipoprotein measurement

C5orf67 HLA-DRB1 TRPS1 INTS10

6.77e-041111054EFO_0004530, EFO_0008595
Diseasefree cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

C5orf67 HLA-DRB1 TRPS1 NHLRC2 INTS10 KPNB1

7.67e-043031056EFO_0004612, EFO_0020945
Diseasepolyunsaturated fatty acids to monounsaturated fatty acids ratio

C5orf67 HLA-DRB1 INTS10

8.05e-04511053EFO_0022302
Diseaseglycoprotein measurement

C5orf67 HLA-DRB1 TRPS1 LILRB5

8.78e-041191054EFO_0004555
Diseasetotal cholesterol measurement, high density lipoprotein cholesterol measurement

C5orf67 HLA-DRB1 TRPS1 NHLRC2 INTS10 LILRB5

9.37e-043151056EFO_0004574, EFO_0004612
Diseasediabetic angiopathy (is_implicated_in)

HLA-DRB1 SOD2

9.54e-04131052DOID:11713 (is_implicated_in)
Diseasetriglycerides in medium VLDL measurement

C5orf67 HLA-DRB1 INTS10

1.00e-03551053EFO_0022155
Diseasefree cholesterol measurement, very low density lipoprotein cholesterol measurement

C5orf67 HLA-DRB1 TRPS1 INTS10 KPNB1

1.05e-032151055EFO_0008317, EFO_0008591
Diseasetriglycerides in large VLDL measurement

C5orf67 HLA-DRB1 INTS10

1.06e-03561053EFO_0022178
Diseasetriglycerides in very large VLDL measurement

C5orf67 HLA-DRB1 INTS10

1.06e-03561053EFO_0022325
Diseasetriglycerides to total lipids in medium HDL percentage

C5orf67 HLA-DRB1 INTS10

1.06e-03561053EFO_0022333
Diseasetriglycerides in chylomicrons and extremely large VLDL measurement

C5orf67 HLA-DRB1 SOD2

1.06e-03561053EFO_0022316
Diseasecholesteryl esters to total lipids in medium HDL percentage

C5orf67 HLA-DRB1 INTS10

1.06e-03561053EFO_0022251
DiseaseSarcomatoid Renal Cell Carcinoma

AHNAK KCNMA1 AKAP13 SOD2

1.15e-031281054C1266043
DiseaseChromophobe Renal Cell Carcinoma

AHNAK KCNMA1 AKAP13 SOD2

1.15e-031281054C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

AHNAK KCNMA1 AKAP13 SOD2

1.15e-031281054C1266044
DiseasePapillary Renal Cell Carcinoma

AHNAK KCNMA1 AKAP13 SOD2

1.15e-031281054C1306837
DiseaseRenal Cell Carcinoma

AHNAK KCNMA1 AKAP13 SOD2

1.15e-031281054C0007134
Diseasevery low density lipoprotein cholesterol measurement, lipid measurement

C5orf67 HLA-DRB1 TRPS1 INTS10 KPNB1

1.16e-032201055EFO_0004529, EFO_0008317
Diseasetriglycerides in IDL measurement

C5orf67 HLA-DRB1 TRPS1

1.17e-03581053EFO_0022149
Diseasetriglycerides in VLDL measurement

C5orf67 HLA-DRB1 INTS10

1.23e-03591053EFO_0022326
Diseasephospholipids in VLDL measurement

C5orf67 HLA-DRB1 INTS10

1.23e-03591053EFO_0022301
Diseaseconcentration of chylomicrons and extremely large VLDL particles measurement

C5orf67 HLA-DRB1 SOD2

1.23e-03591053EFO_0022260
Diseasetotal cholesterol measurement, very low density lipoprotein cholesterol measurement

C5orf67 HLA-DRB1 TRPS1 INTS10 KPNB1

1.26e-032241055EFO_0004574, EFO_0008317
DiseaseNon-steroidal anti-inflammatory and antirheumatic product use measurement

HLA-DRB1 MAML3

1.28e-03151052EFO_0009935
Diseasetriglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

C5orf67 HLA-DRB1 NHLRC2 INTS10 KPNB1

1.28e-032251055EFO_0008317, EFO_0020947
Diseasephospholipids in small VLDL measurement

C5orf67 HLA-DRB1 TRPS1

1.29e-03601053EFO_0022146
DiseaseSjogren syndrome

HLA-DRB1 HLA-DRB3 PHIP

1.29e-03601053EFO_0000699
Diseasetriglycerides to total lipids in large HDL percentage

C5orf67 HLA-DRB1 INTS10

1.29e-03601053EFO_0022330
Diseasetotal lipids in VLDL measurement

C5orf67 HLA-DRB1 INTS10

1.29e-03601053EFO_0022314
Diseasecholesterol to total lipids in medium HDL percentage

C5orf67 HLA-DRB1 INTS10

1.29e-03601053EFO_0022237
Diseasetriglycerides in small VLDL measurement

C5orf67 HLA-DRB1 INTS10

1.36e-03611053EFO_0022145
Diseasefree cholesterol in very large VLDL measurement

C5orf67 HLA-DRB1 INTS10

1.36e-03611053EFO_0022274
Diseasevery low density lipoprotein cholesterol measurement, phospholipid measurement

C5orf67 HLA-DRB1 TRPS1 INTS10 KPNB1

1.39e-032291055EFO_0004639, EFO_0008317
Diseasetriglycerides in small HDL measurement

C5orf67 HLA-DRB1 INTS10

1.42e-03621053EFO_0022158
Diseasephospholipids in large VLDL measurement

C5orf67 HLA-DRB1 INTS10

1.42e-03621053EFO_0022169
Diseasetriglycerides to total lipids in very large HDL percentage

C5orf67 HLA-DRB1 INTS10

1.42e-03621053EFO_0022339
Diseasetotal lipids in chylomicrons and extremely large VLDL measurement

C5orf67 HLA-DRB1 SOD2

1.42e-03621053EFO_0022306
Diseasetotal lipids in very large VLDL measurement

C5orf67 HLA-DRB1 INTS10

1.42e-03621053EFO_0022313
Diseasefree cholesterol in chylomicrons and extremely large VLDL measurement

C5orf67 HLA-DRB1 SOD2

1.42e-03621053EFO_0022263
DiseaseAPOE carrier status, dementia

IRF2BP2 CADM2 FAR2

1.42e-03621053EFO_0007659, MONDO_0001627
Diseasecutaneous melanoma, hair color

C5orf67 PLXNB2 AHNAK

1.42e-03621053EFO_0000389, EFO_0003924
Diseasephospholipids in very large VLDL measurement

C5orf67 HLA-DRB1 INTS10

1.42e-03621053EFO_0022299
Diseasenervousness

CADM2 YLPM1

1.46e-03161052NCIT_C74532
Diseasephospholipids in chylomicrons and extremely large VLDL measurement

C5orf67 HLA-DRB1 SOD2

1.49e-03631053EFO_0022292
DiseaseProfound Mental Retardation

CHD8 CIC NRXN1 PHIP

1.56e-031391054C0020796
DiseaseMental Retardation, Psychosocial

CHD8 CIC NRXN1 PHIP

1.56e-031391054C0025363
DiseaseMental deficiency

CHD8 CIC NRXN1 PHIP

1.56e-031391054C0917816
Diseasecholesterol in large VLDL measurement

C5orf67 HLA-DRB1 INTS10

1.63e-03651053EFO_0021902
Diseasecholesterol in very large VLDL measurement

C5orf67 HLA-DRB1 INTS10

1.63e-03651053EFO_0022230
Diseasevery low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

C5orf67 HLA-DRB1 NHLRC2 INTS10 KPNB1

1.67e-032391055EFO_0008317, EFO_0020945
Diseasevisceral adipose tissue measurement

C5orf67 TRPS1 COL22A1 ADCY2 CADM2 NRXN1 MAML3

1.69e-034811057EFO_0004765
Diseaselow density lipoprotein cholesterol measurement, physical activity

TRPS1 DDX18 KPNB1

1.70e-03661053EFO_0003940, EFO_0004611
Diseaseobesity

DGKD COL22A1 CADM2 DDX18 KCNMA1

1.73e-032411055EFO_0001073
Diseasetotal lipids in large VLDL

C5orf67 HLA-DRB1 INTS10

1.78e-03671053EFO_0022175
Diseasecholesterol to total lipids in very small VLDL percentage

C5orf67 HLA-DRB1 INTS10

1.78e-03671053EFO_0022245
Diseasenephrotic syndrome (is_marker_for)

SOD2 GP1BA

1.85e-03181052DOID:1184 (is_marker_for)
Diseasetriglycerides to phosphoglycerides ratio

C5orf67 HLA-DRB1 INTS10

1.86e-03681053EFO_0022327
Diseasefree cholesterol in large VLDL measurement

C5orf67 HLA-DRB1 INTS10

1.86e-03681053EFO_0022265
Diseasecongenital heart disease (implicated_via_orthology)

CHD8 ADCY2 HCFC1

1.93e-03691053DOID:1682 (implicated_via_orthology)
Diseasetestosterone measurement

IRF2BP2 C5orf67 MAPT HLA-DRB1 IQSEC2 TRPS1 GLYCTK CHRNB1 NRXN1 PHIP ABCC10 KPNB1

1.94e-03127510512EFO_0004908
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

AHNAK KCNMA1 AKAP13 SOD2

1.96e-031481054C0279702
Diseaseparental longevity

PAMR1 HLA-DRB1 COL22A1 PLXNB2 SP110 YLPM1 PHIP

1.96e-034941057EFO_0007796
Diseaseforced expiratory volume

C5orf67 ANK1 HLA-DRB1 SPTBN2 PLXNB2 AHNAK KCNMA1 KIAA2012 PHIP

2.04e-037891059EFO_0004314
Diseasehepatitis B virus infection

HLA-DRB1 HLA-DRB3

2.06e-03191052EFO_0004197
Diseasecolorectal cancer, inflammatory bowel disease

HLA-DRB1 SP110

2.06e-03191052EFO_0003767, MONDO_0005575
DiseaseManic Disorder

NTRK1 ADCY2 ITIH1

2.10e-03711053C0024713

Protein segments in the cluster

PeptideGeneStartEntry
LLGGIGELNKNRHPN

ATP6V1F

21

Q16864
LHPGNILVQGANGLS

ADCK2

446

Q7Z695
VLGSLPGKIVLQGNQ

CHD8

306

Q9HCK8
GPSHEKGNRIVNGQG

ANKRD20A8P

311

Q5CZ79
SNAKFGHPNNIIGVG

ALLC

211

Q8N6M5
LGGQEQAPEHKQEQG

ACRBP

186

Q8NEB7
GNLGNKSGLTPLHLV

ANK1

661

P16157
KPGGRGALSIHNQEG

AKAP13

186

Q12802
LQTGLGPDGQGHQEI

CHRNB1

181

P11230
ASGPELQGAGHSKLQ

AHNAK

231

Q09666
GLNHGPVVAGVIGAQ

ADCY4

986

Q8NFM4
HLNTLEGKKPGNNEG

SNAP91

281

O60641
LGGPQETGQLLEHKL

ALDH3B2

86

P48448
IAGQAGPGHSNTQEK

RAVER2

496

Q9HCJ3
PQEIGIKVKNHSGGG

INTS6L

446

Q5JSJ4
QEGGKIHLELLPNQG

INTS10

641

Q9NVR2
LGIAEQHGGPQNGTL

ANKRD13B

311

Q86YJ7
QHGGPQNGTLITQTL

ANKRD13B

316

Q86YJ7
GQQGVTQVVLKGAPG

HCFC1

826

P51610
NINGPNGIIIATGKG

FAR2

246

Q96K12
QQLKETGHVSGPDGQ

FANCI

851

Q9NVI1
GLSQQHNKGTLNPGL

MAML1

806

Q92585
LVQHQQGLANPGLVG

ABCC10

1171

Q5T3U5
GLGGVPEQKLQCHGQ

NTRK1

166

P04629
GKGSGLQGHIIENPQ

NTRK1

481

P04629
TIIIGGKEQGQPFQG

NRXN1

246

P58400
NGQVLGPGGHVRLKN

IGDCC3

366

Q8IVU1
GPGGHVRLKNNNSTL

IGDCC3

371

Q8IVU1
INPGNHLKIQEGTLG

KCNMA1

646

Q12791
GAGTGKQQHPSKPQQ

MAML3

126

Q96JK9
NGQLIGNKARSPGQH

ITIH1

711

P19827
HNSANKINGIPSGDG

MTMR10

186

Q9NXD2
KGKLLHGQNGSVPNG

KIAA0319L

1021

Q8IZA0
HGQNGSVPNGQTPLK

KIAA0319L

1026

Q8IZA0
HGGLGVLPDGQSKLQ

IQSEC2

1251

Q5JU85
GGQPIDANHLNKGIG

HNRNPM

311

P52272
LGQGIGPIHLNEIQC

LOXL2

381

Q9Y4K0
GQQVHLGSAEGPKVS

HLCS

671

P50747
GKGNGPHDNGIIVST

PLXNB2

171

O15031
DIIGVNGQGPNLEGK

NES

1531

P48681
QGPLAKNHGSQGTRL

KIAA2012

246

Q0VF49
VIQTVNHVLQGPGGK

MNT

451

Q99583
HDLVQGSGQQPQAGL

LILRB5

261

O75023
TIIIGGKEQGQPFQG

NRXN1

1251

Q9ULB1
QKLGNGINIIVATPG

DDX18

296

Q9NVP1
HLLGEKILGSLQQGP

PNPLA7

691

Q6ZV29
KILGSLQQGPVTGHQ

PNPLA7

696

Q6ZV29
DGVGINAKLQHPLGV

NHLRC2

466

Q8NBF2
ETLNLGHNPIGNEGV

PPP1R37

336

O75864
GHNPIGNEGVRHLKN

PPP1R37

341

O75864
RNQKGHSGLQPTGFL

HLA-DRB3

251

P79483
QGQHKGSIEGQGPRR

EFCAB5

576

A4FU69
GAEKLPGQGVHSQGQ

GLG1

26

Q92896
INHGPVIAGVIGAQK

ADCY2

1001

Q08462
GVTAEGIHKNLPGNL

ICE1

1861

Q9Y2F5
GILGAQGQEHPGLNV

C5orf67

81

F2Z3F1
LGQHLVQGVISVPKG

GLYCTK

101

Q8IVS8
NEHNGLIKGQIAGGI

FNDC3A

216

Q9Y2H6
VLNKDIQGGIHGTVP

CPAMD8

1256

Q8IZJ3
GQNGPDHALIGGIVA

CADM2

361

Q8N3J6
RNQKGHSGLQPTGFL

HLA-DRB1

251

P01911
PGSVVQQEGLKGEQG

COL22A1

646

Q8NFW1
AGGIGNQHIPGDNSI

DLG3

241

Q92796
RNQKGHSGLQPTGLL

HLA-DRB4

251

P13762
GIVQGLKGDQENVHP

KPNB1

771

Q14974
GHVKPQALDSGQGAA

GP1BA

556

P07359
AGQVQPGKQELGIHL

ITIH6

506

Q6UXX5
APGANHIVGNKLGEE

INSRR

161

P14616
HKQCQLGVLPLGTGN

DGKD

396

Q16760
GKPTAIHQLLTNGGL

KANSL3

821

Q9P2N6
PQVGGVGGDVQILNK

HAS3

236

O00219
PHTEVPQGKGNVLGN

GOLM1

216

Q8NBJ4
GQVAGPGHQRELKAV

CAND2

851

O75155
PNDKQGLSLVNGHVG

SLC39A12

471

Q504Y0
ILLQQQQQLGHGGPE

IRF2BP2

91

Q7Z5L9
GAQLLHGGLQVPQLS

PRR18

211

Q8N4B5
VEGLHINGPTGGNKK

MIER1

421

Q8N108
QKITGGPGLINGRHA

PAMR1

291

Q6UXH9
SPGGSLGGALQKEQH

INVS

661

Q9Y283
QGPHLRHTGQIGGLK

TARS2

241

Q9BW92
GQLGLGHKEDVLLPQ

SERGEF

26

Q9UGK8
LKVGHVGPLQIGQAV

TRIM32

281

Q13049
QGGNLHGQAESPLGI

LARS1

611

Q9P2J5
LSGGHLIQQVINGGK

FBXL18

326

Q96ME1
GHALAGQTSPKQENG

SAMD11

651

Q96NU1
PQKVNINGGAVSLGH

ACAT1

371

P24752
LENPLGQNGLTHQGL

IARS1

1196

P41252
QGAASPGHGIQEKLQ

SP110

376

Q9HB58
VPGAKVALQHNLGIG

SCP2

381

P22307
HQIIDQVLQGGPGKT

CLMN

381

Q96JQ2
LQPGALGKAGGITQV

CIC

811

Q96RK0
RNPTGGKLHIIEVGQ

CLTCL1

221

P53675
GKLHIIEVGQPAAGN

CLTCL1

226

P53675
VGPGHGIQLQSGRLV

NEU3

161

Q9UQ49
GKQHGAVQSGGLNPE

TRPS1

456

Q9UHF7
GAIHAGQPGKVQQLH

PLEK2

101

Q9NYT0
GVQDQPGQHGKTPSL

ZNF714

526

Q96N38
HSLTQNLLKGLQPGG

UBN2

1296

Q6ZU65
NLLKGLQPGGAQHAA

UBN2

1301

Q6ZU65
PKDQHLNGGVQGIQG

UNC13C

601

Q8NB66
ALVPGTIQVNGHGGQ

PHIP

1616

Q8WWQ0
TIQVNGHGGQPSKLV

PHIP

1621

Q8WWQ0
LEQGQQLVAEGHPGA

SPTBN2

701

O15020
GVGGSLKAPVLNLNQ

STBD1

216

O95210
SPQGHGQQGLLQVLK

TBC1D10C

151

Q8IV04
LNHLGALGSDNPGNK

USP29

781

Q9HBJ7
NAHVVPGSGVVKGLQ

UMPS

341

P11172
SLGNIHHKPGGGQVE

MAPT

641

P10636
IGSLDNITHVPGGGN

MAPT

671

P10636
AGLHPGQCIIKVNGI

PREX2

711

Q70Z35
QIALQPALKFNGGGH

SOD2

81

P04179
GKLLLQHGGPVLLQQ

SLF1

891

Q9BQI6
QHGGPVLLQQRNAKG

SLF1

896

Q9BQI6
GIGLPHSENNQDKGL

YLPM1

986

P49750
ELLIGNNPEVGKGTH

TGM1

166

P22735
GEAGSLQGPVLQHQS

THRA

421

P10827
LVPTANLNHSVGKGG

WDR24

461

Q96S15
NIRGNKQAQGTGHEP

TBC1D2

221

Q9BYX2
GIGGQFLKHQAEAQP

ZNF500

151

O60304
HLNVINDGGPQNGLV

VPS54

931

Q9P1Q0