Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF131 ZNF138 ZNF320 ZNF28 ZNF789 RBAK TRPS1 ZNF215 ZNF468 SOX13 ZNF891 ZNF461 ZNF345	1.12e-04	1412	56	13	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF131 ZNF138 ZNF320 ZNF28 ZNF789 RBAK TRPS1 ZNF215 ZNF468 SOX13 ZNF891 ZNF461 ZNF345	1.56e-04	1459	56	13	GO:0000977
GeneOntologyMolecularFunction	chemoattractant activity	PDGFB VEGFD VEGFB	4.68e-04	54	56	3	GO:0042056
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF131 ZNF138 ZNF320 ZNF28 ZNF789 RBAK ZNF215 ZNF468 SOX13 ZNF461 ZNF345	5.83e-04	1244	56	11	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF131 ZNF138 ZNF320 ZNF28 ZNF789 RBAK ZNF215 ZNF468 SOX13 ZNF461 ZNF345	6.98e-04	1271	56	11	GO:0000987
GeneOntologyMolecularFunction	vascular endothelial growth factor receptor binding	VEGFD VEGFB	1.02e-03	17	56	2	GO:0005172
GeneOntologyMolecularFunction	platelet-derived growth factor receptor binding	PDGFB VEGFD	1.02e-03	17	56	2	GO:0005161
GeneOntologyMolecularFunction	damaged DNA binding	ZNF28 XPA MSH3	1.70e-03	84	56	3	GO:0003684
Domain	zf-C2H2	ZNF131 ZNF138 ZNF320 ZNF28 ZNF789 RBAK TRPS1 ZNF215 ZNF468 ZNF891 ZNF461 ZNF345	7.72e-07	693	56	12	PF00096
Domain	PD_growth_factor_CS	PDGFB VEGFD VEGFB	8.86e-07	7	56	3	IPR023581
Domain	PDGF	PDGFB VEGFD VEGFB	2.12e-06	9	56	3	PF00341
Domain	PDGF_2	PDGFB VEGFD VEGFB	2.12e-06	9	56	3	PS50278
Domain	PDGF_1	PDGFB VEGFD VEGFB	2.12e-06	9	56	3	PS00249
Domain	PDGF/VEGF_dom	PDGFB VEGFD VEGFB	2.12e-06	9	56	3	IPR000072
Domain	PDGF	PDGFB VEGFD VEGFB	2.12e-06	9	56	3	SM00141
Domain	ZINC_FINGER_C2H2_2	ZNF131 ZNF138 ZNF320 ZNF28 ZNF789 RBAK TRPS1 ZNF215 ZNF468 ZNF891 ZNF461 ZNF345	2.49e-06	775	56	12	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF131 ZNF138 ZNF320 ZNF28 ZNF789 RBAK TRPS1 ZNF215 ZNF468 ZNF891 ZNF461 ZNF345	2.55e-06	777	56	12	PS00028
Domain	Znf_C2H2-like	ZNF131 ZNF138 ZNF320 ZNF28 ZNF789 RBAK TRPS1 ZNF215 ZNF468 ZNF891 ZNF461 ZNF345	3.28e-06	796	56	12	IPR015880
Domain	Znf_C2H2	ZNF131 ZNF138 ZNF320 ZNF28 ZNF789 RBAK TRPS1 ZNF215 ZNF468 ZNF891 ZNF461 ZNF345	3.68e-06	805	56	12	IPR007087
Domain	ZnF_C2H2	ZNF131 ZNF138 ZNF320 ZNF28 ZNF789 RBAK TRPS1 ZNF215 ZNF468 ZNF891 ZNF461 ZNF345	3.82e-06	808	56	12	SM00355
Domain	-	ZNF131 ZNF138 ZNF320 ZNF28 ZNF789 RBAK ZNF215 ZNF468 ZNF891 ZNF461 ZNF345	4.53e-06	679	56	11	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF131 ZNF138 ZNF320 ZNF28 ZNF789 RBAK ZNF215 ZNF468 ZNF891 ZNF461 ZNF345	5.58e-06	694	56	11	IPR013087
Domain	KRAB	ZNF320 ZNF28 ZNF789 RBAK ZNF215 ZNF468 ZNF891 ZNF461	1.07e-05	358	56	8	PS50805
Domain	KRAB	ZNF320 ZNF28 ZNF789 RBAK ZNF215 ZNF468 ZNF891 ZNF461	1.07e-05	358	56	8	PF01352
Domain	KRAB	ZNF320 ZNF28 ZNF789 RBAK ZNF215 ZNF468 ZNF891 ZNF461	1.34e-05	369	56	8	SM00349
Domain	KRAB	ZNF320 ZNF28 ZNF789 RBAK ZNF215 ZNF468 ZNF891 ZNF461	1.36e-05	370	56	8	IPR001909
Domain	zf-C2H2_6	ZNF320 ZNF789 ZNF468 ZNF891 ZNF461 ZNF345	3.45e-04	314	56	6	PF13912
Domain	DNA-bd_dom_put	SKIDA1 XPA	4.77e-04	11	56	2	IPR009061
Domain	zf-H2C2_2	ZNF891 ZNF345	7.85e-04	14	56	2	PF13465
Domain	-	PDGFB VEGFD VEGFB	1.07e-03	67	56	3	2.10.90.10
Domain	Cystine-knot_cytokine	PDGFB VEGFD VEGFB	1.07e-03	67	56	3	IPR029034
Pathway	KEGG_RENAL_CELL_CARCINOMA	PDGFB VEGFD VEGFB SOS2	4.02e-05	70	39	4	M13266
Pathway	KEGG_MEDICUS_REFERENCE_GF_RTK_RAS_PI3K_SIGNALING_PATHWAY	PDGFB VEGFD VEGFB SOS2	1.03e-04	89	39	4	M47963
Pathway	KEGG_MEDICUS_REFERENCE_GF_RTK_RAS_ERK_SIGNALING_PATHWAY	PDGFB VEGFD VEGFB SOS2	1.17e-04	92	39	4	M47927
Pathway	REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS	VEGFD VEGFB	2.07e-04	8	39	2	M710
Pathway	REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS	VEGFD VEGFB	2.07e-04	8	39	2	MM14753
Pathway	PID_VEGF_VEGFR_PATHWAY	VEGFD VEGFB	3.31e-04	10	39	2	M137
Pathway	KEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY	PDGFB VEGFD VEGFB	4.65e-04	55	39	3	M47952
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RUFY2 USP34 ACTR8 TRPS1 PDZD8 DCLK2 MSH3 EIF4G3 TTC3 TRIM37 BRWD1 SOS2	9.33e-07	1285	57	12	35914814
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	SART3 ACTR8 DDX59 CCDC66 TRPS1 RSF1 DCLK2 EIF4G3 TTC3 BRWD1	2.35e-06	925	57	10	28986522
Pubmed	Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways.	VEGFD VEGFB	1.58e-05	4	57	2	25435370
Pubmed	Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks.	XPA MSH3	1.58e-05	4	57	2	19468048
Pubmed	Peripheral blood platelets express VEGF-C and VEGF which are released during platelet activation.	VEGFD VEGFB	1.58e-05	4	57	2	9684805
Pubmed	Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects.	VEGFD VEGFB	1.58e-05	4	57	2	19275959
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TRPC4AP INPP4A TLL1 TRPS1 BOD1L1 DCLK2 CEP192 EIF4G3 TTC3 ZNF461 SOS2	2.56e-05	1489	57	11	28611215
Pubmed	COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer.	VEGFD VEGFB	2.63e-05	5	57	2	16570043
Pubmed	Transgenic mouse models in angiogenesis and cardiovascular disease.	VEGFD VEGFB	5.51e-05	7	57	2	10685072
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	USP34 GLG1 BOD1L1 XPA CEP192 TTC3 TRIM37 DYNC1LI2 BRWD1	6.30e-05	1084	57	9	11544199
Pubmed	Genomewide linkage analysis identifies novel genetic Loci for lung function in mice.	PDGFB TRPS1	7.34e-05	8	57	2	15640362
Pubmed	Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos.	VEGFD VEGFB	9.43e-05	9	57	2	15601856
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	SPAG1 TRPC4AP GLG1 RBAK MSH3 TTC3 ZNF461	1.27e-04	686	57	7	29987050
Pubmed	Tbx18 regulates development of the epicardium and coronary vessels.	VEGFD VEGFB	2.37e-04	14	57	2	24016759
Pubmed	Transcription factor CHF1/Hey2 regulates coronary vascular maturation.	PDGFB VEGFB	2.37e-04	14	57	2	20619341
Pubmed	Unpackaging the genetics of mammalian fertility: strategies to identify the "reproductive genome".	EIF4G3 BRWD1	3.12e-04	16	57	2	29878059
Pubmed	Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.	TLL1 TRPS1	3.12e-04	16	57	2	23726511
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	USP34 RBAK TRPS1 KIF16B PWWP3B	3.23e-04	363	57	5	14691545
Pubmed	Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development.	VEGFD VEGFB	3.53e-04	17	57	2	16778080
Pubmed	Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.	ZNF131 ZNF138	3.53e-04	17	57	2	7557990
Pubmed	Regulation of developmental lymphangiogenesis by Syk(+) leukocytes.	PDGFB VEGFD	3.97e-04	18	57	2	20230750
Pubmed	Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development.	PDGFB VEGFD VEGFB	4.43e-04	90	57	3	30228991
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZNF131 RBAK RSF1 BOD1L1 MSH3 BRWD1	4.74e-04	608	57	6	36089195
Pubmed	Meta-analysis identifies four new loci associated with testicular germ cell tumor.	GLG1 TRIM37	4.92e-04	20	57	2	23666239
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SART3 SPAG1 ZNF789 RSF1 SKIDA1 BOD1L1 CNPY2 EIF4G3 TTC3	5.27e-04	1442	57	9	35575683
Pubmed	Coronary development is regulated by ATP-dependent SWI/SNF chromatin remodeling component BAF180.	PDGFB VEGFB	5.43e-04	21	57	2	18508041
Pubmed	Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.	ZNF461 ZNF345	5.43e-04	21	57	2	7865130
Pubmed	Wdpcp promotes epicardial EMT and epicardium-derived cell migration to facilitate coronary artery remodeling.	VEGFD VEGFB	5.43e-04	21	57	2	29487191
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	USP34 SPON1 DGKB	6.21e-04	101	57	3	9872452
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	SART3 ZNF131 GLG1 KIF16B PDZD8 CEP192 CNPY2 EIF4G3 TTC3	6.57e-04	1487	57	9	33957083
Pubmed	Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling.	KCNF1 SPON1 FGL2	7.54e-04	108	57	3	31202927
Pubmed	Candidate gene analysis in primary lymphedema.	VEGFD VEGFB	7.73e-04	25	57	2	18564921
Pubmed	Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation.	PDGFB VEGFB	8.36e-04	26	57	2	31138536
Pubmed	Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.	PDGFB VEGFD	9.71e-04	28	57	2	18593464
Pubmed	Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.	PDZD8 BRWD1	1.04e-03	29	57	2	21834987
Pubmed	Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21.	TTC3 BRWD1	1.11e-03	30	57	2	11374901
Pubmed	EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.	TRPS1 MSH3 SOX13	1.23e-03	128	57	3	23858473
Pubmed	Secondary Placental Defects in Cxadr Mutant Mice.	VEGFD VEGFB	1.27e-03	32	57	2	31338035
Pubmed	Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.	TRPC4AP BRWD1	1.27e-03	32	57	2	16964240
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	SART3 USP34 TRPS1 RSF1 BOD1L1 XPA MSH3	1.30e-03	1014	57	7	32416067
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	SART3 SPAG1 ACTR8 DDX59	1.50e-03	300	57	4	28561026
Pubmed	Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.	ACTR8 OC90	1.52e-03	35	57	2	15188402
Cytoband	19q13.41	ZNF320 ZNF28 ZNF468	1.29e-04	78	57	3	19q13.41
Cytoband	21q22.2	TTC3 BRWD1	7.80e-04	33	57	2	21q22.2
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF131 ZNF138 ZNF320 ZNF28 ZNF789 RBAK TRPS1 ZNF215 ZNF468 ZNF891 ZNF461 ZNF345	6.94e-08	718	43	12	28
GeneFamily	VEGF family	VEGFD VEGFB	5.50e-05	5	43	2	1267
Coexpression	ZHANG_BREAST_CANCER_PROGENITORS_UP	USP34 RBAK TRPS1 KIF16B PDZD8 CEP192 TTC3 TRIM37	4.30e-06	434	57	8	M15150
Coexpression	GSE45365_NK_CELL_VS_CD8_TCELL_MCMV_INFECTION_UP	TRPS1 KIF16B ZNF468 EIF4G3 TTC3 FGL2	4.54e-06	198	57	6	M9960
Coexpression	ZHANG_BREAST_CANCER_PROGENITORS_UP	USP34 RBAK TRPS1 KIF16B PDZD8 CEP192 TTC3 TRIM37	5.43e-06	448	57	8	MM1044
CoexpressionAtlas	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4	RUFY2 DDX59 CCDC66 GARNL3 SPON1 TLL1 RSF1 SKIDA1 BOD1L1 DCLK2 PWWP3B TTC3 TRIM37 BRWD1 SOS2	2.17e-06	1370	57	15	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4
CoexpressionAtlas	facebase_RNAseq_e10.5_MandArch_2500_K1	RUFY2 CCDC66 TLL1 TRPS1 RSF1 BOD1L1 XPA CEP192 MSH3 PWWP3B CNPY2 BRWD1	9.18e-05	1241	57	12	facebase_RNAseq_e10.5_MandArch_2500_K1
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_MedNas_2500_K1	TRAPPC11 DDX59 CCDC66 SPON1 TLL1 TRPS1 SKIDA1 BOD1L1 CEP192 TRIM37 BRWD1	1.01e-04	1060	57	11	facebase_RNAseq_e10.5_Emin_MedNas_2500_K1
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3	RUFY2 DDX59 CCDC66 GARNL3 TLL1 TRPS1 RSF1 BOD1L1 CEP192 PWWP3B TRIM37 BRWD1	1.04e-04	1257	57	12	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlas	facebase_RNAseq_e10.5_MandArch_2500	RUFY2 CCDC66 TLL1 TRPS1 RSF1 BOD1L1 XPA CEP192 MSH3 PWWP3B CNPY2 VEGFD BRWD1	1.09e-04	1468	57	13	facebase_RNAseq_e10.5_MandArch_2500
Drug	Pyridoxine hydrochloride [58-56-0]; Up 200; 19.4uM; PC3; HT_HG-U133A	GLG1 SPON1 SOX13 PID1 BRWD1 SOS2	9.22e-06	195	57	6	5813_UP
Drug	Guaifenesin [93-14-1]; Down 200; 20.2uM; PC3; HT_HG-U133A	GLG1 MSH3 SOX13 PID1 BRWD1 SOS2	9.50e-06	196	57	6	4549_DN
Disease	R-6-hydroxywarfarin to R-warfarin ratio measurement	EYS DGKB SOX13	1.03e-03	106	55	3	EFO_0803333
Disease	retinitis pigmentosa (implicated_via_orthology)	EYS CCDC66	1.16e-03	27	55	2	DOID:10584 (implicated_via_orthology)
Disease	chronotype measurement	USP34 KCNF1 TRPS1 KIF16B PDZD8 EIF4G3 TRIM37	1.21e-03	882	55	7	EFO_0008328
Disease	reaction time measurement	SPON1 CEP192 MSH3 EIF4G3 PID1 OC90	1.38e-03	658	55	6	EFO_0008393
Disease	pit and fissure surface dental caries	PDZD8 OC90	1.95e-03	35	55	2	EFO_0006338
Disease	Stuttering	USP34 INPP4A KIF16B	2.43e-03	143	55	3	HP_0025268
Disease	nasopharyngeal neoplasm	EYS DGKB PID1	2.84e-03	151	55	3	EFO_0004252
Disease	3-hydroxy-1-methylpropylmercapturic acid measurement	USP34 PWWP3B PID1 SOS2	4.21e-03	352	55	4	EFO_0007015
Disease	age at menarche	USP34 ZNF131 RSF1 EIF4G3 BRWD1	4.94e-03	594	55	5	EFO_0004703

Protein segments in the cluster

Peptide	Gene	Start	Entry
LHSIDCCSSDDTKKK	ACTR8	516	Q9H981
ELLKEKCKATCLCEN	CRISP2	226	P16562
LECLKCEHDKESRLL	KIF16B	861	Q96L93
KFEETKKHFEECCTS	INPP4A	381	Q96PE3
SKSLEKLKEFCCDSA	MSH3	131	P20585
TEKNCEKAIDHCKLL	EYS	401	Q5T1H1
CESKCDSHLKHSLKL	CHL1	536	O00533
DKAKCCGKEHLIENE	DCLK2	426	Q8N568
CTKCDAVSVLEKEHD	DYNC1LI2	231	O43237
KTDEDVCSLECKAKH	DDX59	121	Q5T1V6
KKATVTLEDHLACKC	PDGFB	166	P01127
DCHAVECESKLEAKK	PID1	196	Q7Z2X4
CHKKCQEKCLAETSV	PDZD8	876	Q8NEN9
LKKCIEDKIHLCEEQ	EVC2	921	Q86UK5
VSKKIICESKDNCEH	OC90	146	Q02509
DSKETLKTSEHCEKE	BOD1L1	596	Q8NFC6
ECLKENKKQLSTRCH	GLG1	846	Q92896
DKLCSKRTDLCDHAL	CNPY2	161	Q9Y2B0
STKDLCKQCIDKDCL	CCDC66	91	A2RUB6
ATCKKLHESVEIECD	DGKB	631	Q9Y6T7
HLACTTAKKKLSDCE	BRWD1	1966	Q9NSI6
TCECHESIEKNKDKT	CEP192	451	Q8TEP8
SLKKSCQDCKLQADD	FGL2	91	Q14314
DHCEKLASEKEVVEC	RSF1	636	Q96T23
SCTKEELEEICKAHG	SART3	811	Q15020
KLLKNHDEESLECLC	EIF4G3	916	O43432
DCRENKLEKTKGCHL	GARNL3	576	Q5VVW2
TSCKDKKEIRACNVH	SPON1	791	Q9HCB6
LCSLTKHEENEKDKC	TRIM37	81	O94972
KIQICDKEDTCEHKH	SOS2	496	Q07890
KEATHCKLCEKEFSL	RUFY2	541	Q8WXA3
LHKDKDSTCLENSSC	TRPC4AP	741	Q8TEL6
KHDCKEAECEQKIHS	TLL1	766	O43897
HSAVKEESACVKDEK	PWWP3B	221	Q5H9M0
HLFTNKLKCECNDTK	SKIDA1	701	Q1XH10
KESKEHSCTKCDFIT	TRPS1	661	Q9UHF7
NCTIKSEEKKEPCHE	SOX13	21	Q9UN79
CEECDKVFSRKSHLE	ZNF320	331	A2RRD8
EEKEIVCKCHKDETV	TRAPPC11	866	Q7Z392
ENKHFRCKECDKSLC	ZNF138	106	P52744
HELDSSKQEDKCLRC	PAPLN	161	O95428
RKVHTEEKSHECSEC	RBAK	476	Q9NYW8
EKCSDVKHLEKILCV	SPAG1	31	Q07617
KVADEALKVDDCDCH	TTC3	411	P53804
LEEHSQCECRPKKKD	VEGFB	116	P49765
CDNCRDADDKHKLIT	XPA	126	P23025
QKLHAEAKACTSNKC	ZNF215	426	Q9UL58
CEECDKVFSRKSHLE	ZNF28	301	P17035
KSHSTESFKCEICNK	ZNF131	281	P52739
HTDEKLLECKECGKD	ZNF345	56	Q14585
DCKEFKDLHCSKDST	USP34	3446	Q70CQ2
FECKESLETCCQKHK	VEGFD	291	O43915
CEECDKVFSRKSHLE	ZNF468	301	Q5VIY5
CNKDETLCHQSSLKK	ZNF891	296	A8MT65
KRTHSKELSECKECT	ZNF461	211	Q8TAF7
SEKLHKCKEFVDSCR	ZNF789	126	Q5FWF6
CCKSHLSEKREELEE	KCNF1	126	Q9H3M0