Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	exonuclease activity	CNOT6 REXO5 DIS3L POLE HELZ2 POLRMT	3.03e-06	92	87	6	GO:0004527
GeneOntologyMolecularFunction	retinoic acid binding	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.35e-06	28	87	4	GO:0001972
GeneOntologyMolecularFunction	3'-5' exonuclease activity	CNOT6 DIS3L POLE HELZ2 POLRMT	6.86e-06	61	87	5	GO:0008408
GeneOntologyMolecularFunction	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	CNOT6 DIS3L POLE HELZ2 POLRMT	7.44e-06	62	87	5	GO:0016796
GeneOntologyMolecularFunction	glucuronosyltransferase activity	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.59e-05	35	87	4	GO:0015020
GeneOntologyMolecularFunction	3'-5'-RNA exonuclease activity	CNOT6 DIS3L HELZ2 POLRMT	1.99e-05	37	87	4	GO:0000175
GeneOntologyMolecularFunction	RNA exonuclease activity, producing 5'-phosphomonoesters	CNOT6 DIS3L HELZ2 POLRMT	2.73e-05	40	87	4	GO:0016896
GeneOntologyMolecularFunction	RNA exonuclease activity	CNOT6 DIS3L HELZ2 POLRMT	4.37e-05	45	87	4	GO:0004532
GeneOntologyMolecularFunction	exoribonuclease II activity	DIS3L HELZ2	5.61e-05	3	87	2	GO:0008859
GeneOntologyMolecularFunction	retinoid binding	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.65e-05	48	87	4	GO:0005501
GeneOntologyMolecularFunction	isoprenoid binding	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.13e-05	49	87	4	GO:0019840
GeneOntologyMolecularFunction	nuclease activity	CNOT6 REXO5 DIS3L POLE HELZ2 POLRMT SLFN14	6.75e-05	231	87	7	GO:0004518
GeneOntologyMolecularFunction	protein kinase C binding	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.97e-04	66	87	4	GO:0005080
GeneOntologyMolecularFunction	fatty acid binding	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.34e-04	69	87	4	GO:0005504
GeneOntologyMolecularFunction	hexosyltransferase activity	FUT10 MGAT4B UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.21e-04	211	87	6	GO:0016758
GeneOntologyMolecularFunction	RNA nuclease activity	CNOT6 DIS3L HELZ2 POLRMT SLFN14	3.22e-04	136	87	5	GO:0004540
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	MGAT4B UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.51e-04	153	87	5	GO:0008194
GeneOntologyMolecularFunction	monocarboxylic acid binding	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.23e-03	107	87	4	GO:0033293
GeneOntologyMolecularFunction	hydrolase activity, acting on ether bonds	TMEM86B EPHX3	1.42e-03	13	87	2	GO:0016801
GeneOntologyMolecularFunction	ether hydrolase activity	TMEM86B EPHX3	1.42e-03	13	87	2	GO:0016803
GeneOntologyMolecularFunction	glycosyltransferase activity	FUT10 MGAT4B UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.62e-03	288	87	6	GO:0016757
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	CNOT6 EARS2 DIS3L POLE HELZ2 POLRMT SPO11 SLFN14 MUTYH	1.97e-03	645	87	9	GO:0140640
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	CNOT6 PIKFYVE REXO5 DIS3L PLCXD1 PDP1 POLE HELZ2 POLRMT SLFN14	2.65e-03	807	87	10	GO:0016788
GeneOntologyMolecularFunction	steroid binding	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.73e-03	133	87	4	GO:0005496
GeneOntologyBiologicalProcess	estrogen catabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.40e-09	5	86	4	GO:0006711
GeneOntologyBiologicalProcess	phenylpropanoid catabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.20e-09	6	86	4	GO:0046271
GeneOntologyBiologicalProcess	coumarin catabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.20e-09	6	86	4	GO:0046226
GeneOntologyBiologicalProcess	flavone metabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.20e-09	6	86	4	GO:0051552
GeneOntologyBiologicalProcess	phenylpropanoid metabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.80e-08	10	86	4	GO:0009698
GeneOntologyBiologicalProcess	coumarin metabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.80e-08	10	86	4	GO:0009804
GeneOntologyBiologicalProcess	flavonoid metabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.96e-07	13	86	4	GO:0009812
GeneOntologyBiologicalProcess	flavonoid glucuronidation	UGT1A8 UGT1A7 UGT1A9	6.96e-07	5	86	3	GO:0052696
GeneOntologyBiologicalProcess	cellular glucuronidation	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.60e-06	21	86	4	GO:0052695
GeneOntologyBiologicalProcess	hormone catabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.60e-06	21	86	4	GO:0042447
GeneOntologyBiologicalProcess	glucuronate metabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.93e-06	26	86	4	GO:0019585
GeneOntologyBiologicalProcess	uronic acid metabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.93e-06	26	86	4	GO:0006063
GeneOntologyBiologicalProcess	steroid catabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.19e-05	34	86	4	GO:0006706
GeneOntologyBiologicalProcess	xenobiotic glucuronidation	UGT1A8 UGT1A7 UGT1A9	1.50e-05	12	86	3	GO:0052697
GeneOntologyBiologicalProcess	estrogen metabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.55e-05	52	86	4	GO:0008210
GeneOntologyBiologicalProcess	monocyte homeostasis	MPL SH2B3	1.70e-04	5	86	2	GO:0035702
GeneOntologyBiologicalProcess	thrombopoietin-mediated signaling pathway	MPL SH2B3	1.70e-04	5	86	2	GO:0038163
GeneOntologyBiologicalProcess	secondary metabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.77e-04	67	86	4	GO:0019748
HumanPheno	Bruising susceptibility	MPL FANCC SH2B3 ADAMTS2 GATA2 SLFN14 LYST GP1BA SOS2	2.04e-06	178	35	9	HP:0000978
HumanPheno	Prolonged bleeding time	MPL SH2B3 ADAMTS2 GATA2 GP1BA	1.93e-05	50	35	5	HP:0003010
HumanPheno	Abnormal megakaryocyte morphology	MPL SH2B3 GATA2 GP1BA	3.40e-05	28	35	4	HP:0012143
HumanPheno	Subcutaneous hemorrhage	MPL FANCC SH2B3 ADAMTS2 GATA2 SLFN14 LYST GP1BA SOS2	4.22e-05	258	35	9	HP:0001933
Domain	UDPGT	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.25e-06	21	85	4	PF00201
Domain	UDPGT	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.25e-06	21	85	4	PS00375
Domain	UDP_glucos_trans	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.25e-06	21	85	4	IPR002213
Domain	RNase_II/R_CS	DIS3L HELZ2	1.22e-04	4	85	2	IPR022966
Domain	GDS_CDC24_CS	PLEKHG4 ARHGEF11 SOS2	7.39e-04	39	85	3	IPR001331
Domain	PH	SH2B3 PLEKHG4 GRB14 PLEKHH2 ARHGEF11 SOS2	1.69e-03	278	85	6	SM00233
Domain	PH_DOMAIN	SH2B3 PLEKHG4 GRB14 PLEKHH2 ARHGEF11 SOS2	1.72e-03	279	85	6	PS50003
Domain	PH_domain	SH2B3 PLEKHG4 GRB14 PLEKHH2 ARHGEF11 SOS2	1.75e-03	280	85	6	IPR001849
Domain	LRRNT	LRRC55 NTRK3 GP1BA	1.81e-03	53	85	3	PF01462
Domain	DH_1	PLEKHG4 ARHGEF11 SOS2	2.97e-03	63	85	3	PS00741
Domain	PH_dom-like	SH2B3 PLEKHG4 GRB14 PLEKHH2 ARHGEF11 LYST SOS2	3.27e-03	426	85	7	IPR011993
Domain	RhoGEF	PLEKHG4 ARHGEF11 SOS2	3.68e-03	68	85	3	SM00325
Domain	PH	SH2B3 PLEKHG4 GRB14 PLEKHH2 SOS2	3.93e-03	229	85	5	PF00169
Domain	RhoGEF	PLEKHG4 ARHGEF11 SOS2	4.00e-03	70	85	3	PF00621
Domain	DH_2	PLEKHG4 ARHGEF11 SOS2	4.00e-03	70	85	3	PS50010
Domain	DH-domain	PLEKHG4 ARHGEF11 SOS2	4.16e-03	71	85	3	IPR000219
Domain	-	PLEKHG4 ARHGEF11 SOS2	4.16e-03	71	85	3	1.20.900.10
Domain	MetalloPept_cat_dom	ADAMTS2 ADAM15 MMP11	6.01e-03	81	85	3	IPR024079
Domain	-	ADAMTS2 ADAM15 MMP11	6.01e-03	81	85	3	3.40.390.10
Domain	LRR_8	CNOT6 LRRC55 NTRK3 GP1BA	7.73e-03	171	85	4	PF13855
Domain	Cys-rich_flank_reg_C	LRRC55 NTRK3 GP1BA	8.04e-03	90	85	3	IPR000483
Domain	LRRCT	LRRC55 NTRK3 GP1BA	8.04e-03	90	85	3	SM00082
Domain	-	SH2B3 PLEKHG4 GRB14 PLEKHH2 ARHGEF11 SOS2	8.84e-03	391	85	6	2.30.29.30
Pathway	KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	EARS2 UGT1A10 UGT1A8 UGT1A7 UGT1A9	9.26e-07	41	62	5	M7399
Pathway	WP_ESTROGEN_METABOLISM	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.34e-06	22	62	4	MM15888
Pathway	REACTOME_GLUCURONIDATION	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.37e-06	24	62	4	MM14599
Pathway	REACTOME_GLUCURONIDATION	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.00e-06	25	62	4	M17787
Pathway	WP_GLUCURONIDATION	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.00e-06	25	62	4	MM15820
Pathway	KEGG_ASCORBATE_AND_ALDARATE_METABOLISM	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.00e-06	25	62	4	M605
Pathway	WP_GLUCURONIDATION	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.72e-06	26	62	4	M39404
Pathway	KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.42e-06	28	62	4	M19580
Pathway	REACTOME_PARACETAMOL_ADME	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.49e-05	39	62	4	MM15695
Pathway	WP_CODEINE_AND_MORPHINE_METABOLISM	UGT1A10 UGT1A8 UGT1A9	2.85e-05	14	62	3	M39328
Pathway	REACTOME_ASPIRIN_ADME	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.42e-05	45	62	4	MM15694
Pathway	KEGG_DRUG_METABOLISM_OTHER_ENZYMES	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.26e-05	51	62	4	M17726
Pathway	KEGG_STARCH_AND_SUCROSE_METABOLISM	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.84e-05	52	62	4	M14171
Pathway	KEGG_STEROID_HORMONE_BIOSYNTHESIS	UGT1A10 UGT1A8 UGT1A7 UGT1A9	9.78e-05	55	62	4	M14933
Pathway	KEGG_RETINOL_METABOLISM	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.77e-04	64	62	4	M9488
Pathway	KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.50e-04	70	62	4	M16794
Pathway	KEGG_DRUG_METABOLISM_CYTOCHROME_P450	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.79e-04	72	62	4	M9257
Pathway	REACTOME_GLYCOSPHINGOLIPID_TRANSPORT	ESYT3 CLN3	5.24e-04	8	62	2	M48263
Pathway	REACTOME_GLYCOSPHINGOLIPID_TRANSPORT	ESYT3 CLN3	5.24e-04	8	62	2	MM17237
Pathway	REACTOME_ASPIRIN_ADME	UGT1A8 UGT1A7 UGT1A9	9.44e-04	44	62	3	M45014
Pathway	WP_IRINOTECAN_PATHWAY	UGT1A10 UGT1A9	1.22e-03	12	62	2	M39611
Pathway	REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.25e-03	107	62	4	MM14595
Pathway	REACTOME_DRUG_ADME	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.34e-03	109	62	4	M45012
Pathway	REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.34e-03	109	62	4	M18788
Pathway	REACTOME_SYNTHESIS_OF_PE	ETNK1 PISD	1.44e-03	13	62	2	M656
Pathway	WP_KENNEDY_PATHWAY_FROM_SPHINGOLIPIDS	ETNK1 PISD	1.67e-03	14	62	2	M39620
Pathway	WP_KENNEDY_PATHWAY	ETNK1 PISD	1.67e-03	14	62	2	MM15980
Pathway	REACTOME_DRUG_ADME	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.85e-03	119	62	4	MM15692
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TAOK2 PIKFYVE MGAT4B INTS5 SH2B3 CLN3 POLE MCM3AP TMEM132A GATA2 HELZ2 FBRSL1 POLRMT USP7 RHOT2 NUP188 ARHGEF11 LYST HR	4.11e-11	1105	89	19	35748872
Pubmed	Circadian Clock Component Rev-erbα Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.99e-10	6	89	4	32527940
Pubmed	Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.99e-10	6	89	4	20297805
Pubmed	Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.39e-09	7	89	4	8467709
Pubmed	Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p).	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.39e-09	7	89	4	8464825
Pubmed	Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.39e-09	7	89	4	27514509
Pubmed	Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.78e-09	8	89	4	17179145
Pubmed	Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.78e-09	8	89	4	20610558
Pubmed	Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.78e-09	8	89	4	18052087
Pubmed	A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.00e-09	9	89	4	22511988
Pubmed	Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	8.31e-09	10	89	4	23642732
Pubmed	UDP-glucuronosyltransferases.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	8.31e-09	10	89	4	11465080
Pubmed	A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	8.31e-09	10	89	4	23371916
Pubmed	A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	8.31e-09	10	89	4	22558097
Pubmed	Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element.	UGT1A10 UGT1A8 UGT1A9	1.62e-08	3	89	3	29519853
Pubmed	Cloning and characterization of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 gene promoters: differential regulation through an interior-like region.	UGT1A10 UGT1A8 UGT1A9	1.62e-08	3	89	3	12847094
Pubmed	Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.95e-08	12	89	4	20308471
Pubmed	Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.95e-08	12	89	4	19419973
Pubmed	Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.95e-08	12	89	4	11434514
Pubmed	UGT1A1 is a major locus influencing bilirubin levels in African Americans.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.81e-08	13	89	4	22085899
Pubmed	Genome-wide analysis of hepatic lipid content in extreme obesity.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.81e-08	13	89	4	25246029
Pubmed	Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.93e-08	14	89	4	21646302
Pubmed	Human UDP-glucuronosyltransferases: metabolism, expression, and disease.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.93e-08	14	89	4	10836148
Pubmed	Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.93e-08	14	89	4	14672974
Pubmed	The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.93e-08	14	89	4	9295054
Pubmed	Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A16 and 28.	UGT1A10 UGT1A7 UGT1A9	6.47e-08	4	89	3	17558305
Pubmed	Genome-wide association meta-analysis for total serum bilirubin levels.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.12e-08	16	89	4	19414484
Pubmed	Genome-wide association of serum bilirubin levels in Korean population.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	9.29e-08	17	89	4	20639394
Pubmed	Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.19e-07	18	89	4	20056724
Pubmed	A genome-wide assessment of variability in human serum metabolism.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.51e-07	19	89	4	23281178
Pubmed	Risk of diarrhoea in a long-term cohort of renal transplant patients given mycophenolate mofetil: the significant role of the UGT1A8 2 variant allele.	UGT1A8 UGT1A7 UGT1A9	1.61e-07	5	89	3	20565459
Pubmed	Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4.	UGT1A10 UGT1A8 UGT1A9	1.61e-07	5	89	3	15057901
Pubmed	Genetic determinants influencing human serum metabolome among African Americans.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.09e-07	24	89	4	24625756
Pubmed	Family-based genome-wide association scan of attention-deficit/hyperactivity disorder.	UGT1A10 UGT1A8 UGT1A9	1.35e-06	9	89	3	20732626
Pubmed	Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients.	UGT1A8 UGT1A7 UGT1A9	2.63e-06	11	89	3	18695635
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SMG7 EARS2 DIS3L FAM120C PLCXD1 MCM3AP PRSS56 FBRSL1 POLRMT USP7 RHOT2 NUP188 ZDHHC13	5.24e-06	1116	89	13	31753913
Pubmed	Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders.	MPL SH2B3	6.48e-06	2	89	2	17693582
Pubmed	Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10.	UGT1A10 UGT1A9	6.48e-06	2	89	2	25547628
Pubmed	Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues.	UGT1A10 UGT1A8	6.48e-06	2	89	2	11901093
Pubmed	Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene.	UGT1A7 UGT1A9	6.48e-06	2	89	2	11677206
Pubmed	Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine.	UGT1A10 UGT1A9	6.48e-06	2	89	2	22031623
Pubmed	Studies on the substrate specificity of human intestinal UDP- lucuronosyltransferases 1A8 and 1A10.	UGT1A10 UGT1A8	6.48e-06	2	89	2	10497143
Pubmed	Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors.	UGT1A8 UGT1A9	6.48e-06	2	89	2	18568343
Pubmed	Human UGT1A8 and UGT1A10 mRNA are expressed in primary human hepatocytes.	UGT1A10 UGT1A8	6.48e-06	2	89	2	17603215
Pubmed	UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan.	UGT1A7 UGT1A9	6.48e-06	2	89	2	15709193
Pubmed	Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs.	UGT1A7 UGT1A9	6.48e-06	2	89	2	12944498
Pubmed	Inhibition of neutrophil elastase suppresses the development of skin tumors in hairless mice.	LYST HR	6.48e-06	2	89	2	8757756
Pubmed	Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon.	UGT1A10 UGT1A8	6.48e-06	2	89	2	9647757
Pubmed	Influence of UGT1A7 and UGT1A9 intronic I399 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients.	UGT1A7 UGT1A9	6.48e-06	2	89	2	17529886
Pubmed	How many and which amino acids are responsible for the large activity differences between the highly homologous UDP-glucuronosyltransferases (UGT) 1A9 and UGT1A10?	UGT1A10 UGT1A9	6.48e-06	2	89	2	20089735
Pubmed	Morphological, immunophenotypical and molecular features of hypermutation in colorectal carcinomas with mutations in DNA polymerase ε (POLE).	POLE NTRK3	6.48e-06	2	89	2	31479159
Pubmed	Human metabolic individuality in biomedical and pharmaceutical research.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.43e-05	57	89	4	21886157
Pubmed	Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis.	MPL SH2B3	1.94e-05	3	89	2	15337790
Pubmed	HELZ2: a new, interferon-regulated, human 3'-5' exoribonuclease of the RNB family is expressed from a non-canonical initiation codon.	DIS3L HELZ2	1.94e-05	3	89	2	37602378
Pubmed	Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan.	UGT1A7 UGT1A9	1.94e-05	3	89	2	19364970
Pubmed	Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin.	UGT1A7 UGT1A9	1.94e-05	3	89	2	16636344
Pubmed	Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases.	UGT1A10 UGT1A9	1.94e-05	3	89	2	20007669
Pubmed	Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2.	MPL SH2B3	1.94e-05	3	89	2	18618018
Pubmed	Genetic polymorphisms of UGT1A8, UGT1A9 and HNF-1α and gastrointestinal symptoms in renal transplant recipients taking mycophenolic acid.	UGT1A8 UGT1A9	1.94e-05	3	89	2	23721685
Pubmed	Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites.	UGT1A10 UGT1A8	1.94e-05	3	89	2	19244109
Pubmed	Raloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8 and UGT1A9.	UGT1A8 UGT1A9	1.94e-05	3	89	2	26247833
Pubmed	The impact of UGT1A8, UGT1A9, and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy volunteers.	UGT1A8 UGT1A9	1.94e-05	3	89	2	17339869
Pubmed	Differences in UGT1A1, UGT1A7, and UGT1A9 polymorphisms between Uzbek and Japanese populations.	UGT1A7 UGT1A9	1.94e-05	3	89	2	24453052
Pubmed	UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipients.	UGT1A8 UGT1A9	1.94e-05	3	89	2	19225446
Pubmed	[Influence of genetic polymorphisms in UGT1A1, UGT1A7 and UGT1A9 on the pharmacokynetics of irinotecan, SN-38 and SN-38G].	UGT1A7 UGT1A9	1.94e-05	3	89	2	23789755
Pubmed	Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer.	UGT1A7 UGT1A9	1.94e-05	3	89	2	17406868
Pubmed	Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions.	UGT1A8 UGT1A7	1.94e-05	3	89	2	19996319
Pubmed	Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone.	UGT1A8 UGT1A9	1.94e-05	3	89	2	16397224
Pubmed	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.56e-05	66	89	4	19898482
Pubmed	Influence of uridine diphosphate (UDP)-glucuronosyltransferases and ABCC2 genetic polymorphisms on the pharmacokinetics of mycophenolic acid and its metabolites in Chinese renal transplant recipients.	UGT1A8 UGT1A9	3.87e-05	4	89	2	18946804
Pubmed	Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV.	PIKFYVE TPCN2	3.87e-05	4	89	2	32221306
Pubmed	Population pharmacokinetics and pharmacogenetics of mycophenolic acid following administration of mycophenolate mofetil in de novo pediatric renal-transplant patients.	UGT1A8 UGT1A9	3.87e-05	4	89	2	20147615
Pubmed	LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.	MPL SH2B3	3.87e-05	4	89	2	26974155
Pubmed	UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy.	UGT1A7 UGT1A9	3.87e-05	4	89	2	20628391
Pubmed	Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue.	UGT1A10 UGT1A7	3.87e-05	4	89	2	9271343
Pubmed	Clinical significance of Gata-1, Gata-2, EKLF, and c-MPL expression in acute myeloid leukemia.	MPL GATA2	3.87e-05	4	89	2	19097174
Pubmed	Genetic polymorphisms of UGT1A8, UGT1A9, UGT2B7 and ABCC2 in Chinese renal transplant recipients and a comparison with other ethnic populations.	UGT1A8 UGT1A9	3.87e-05	4	89	2	23700788
Pubmed	Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1.	UGT1A10 UGT1A9	3.87e-05	4	89	2	2108603
Pubmed	Pharmacokinetics of mycophenolate mofetil and its glucuronide metabolites in healthy volunteers.	UGT1A7 UGT1A9	6.44e-05	5	89	2	18597651
Pubmed	The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C.	UGT1A10 UGT1A7	6.44e-05	5	89	2	18556656
Pubmed	Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients.	UGT1A7 UGT1A9	6.44e-05	5	89	2	17072959
Pubmed	Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population.	UGT1A7 UGT1A9	9.65e-05	6	89	2	19204906
Pubmed	An atlas of genetic influences on human blood metabolites.	SH2B3 UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.32e-04	190	89	5	24816252
Pubmed	The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination.	MPL SH2B3	1.35e-04	7	89	2	30755420
Pubmed	Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism.	UGT1A8 UGT1A9	1.79e-04	8	89	2	12695355
Pubmed	Genetically determined murine models of immunodeficiency.	LYST HR	1.79e-04	8	89	2	3297105
Pubmed	Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk.	UGT1A8 UGT1A7	1.79e-04	8	89	2	15319294
Pubmed	Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins.	MPL GP1BA	2.30e-04	9	89	2	16757682
Pubmed	A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.	UGT1A8 UGT1A9	2.30e-04	9	89	2	1339448
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	TAOK2 EARS2 FAM120C MCM3AP PISD NUP188	2.49e-04	341	89	6	32971831
Pubmed	Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen.	LYST HR	2.88e-04	10	89	2	9328433
Pubmed	Genetic evidence for a role of IL33 in nasal polyposis.	SH2B3 GATA2	2.88e-04	10	89	2	19860791
Pubmed	Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.	SH2B3 GATA2	3.51e-04	11	89	2	19198610
Pubmed	Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor.	MPL GATA2	3.51e-04	11	89	2	8799165
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	TAOK2 MCM3AP TMEM132A ARHGEF11	3.56e-04	130	89	4	12421765
Pubmed	Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.	UGT1A7 UGT1A9	4.20e-04	12	89	2	19349540
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TAOK2 CNOT6 INTS5 SMG7 EARS2 FBRSL1 NUP188	4.26e-04	529	89	7	14621295
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	POLE GATA2 HELZ2 USP7	5.66e-04	147	89	4	29576527
Pubmed	Mutations in mice that influence natural killer (NK) cell activity.	LYST HR	5.78e-04	14	89	2	6971254
Pubmed	A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.	UGT1A10 UGT1A8	7.59e-04	16	89	2	20972438
Interaction	TOP3B interactions	TAOK2 PIKFYVE MGAT4B INTS5 SMG7 SH2B3 FAM120C CLN3 POLE MCM3AP TMEM132A GATA2 HELZ2 FBRSL1 POLRMT USP7 RHOT2 NUP188 ARHGEF11 LYST HR	6.66e-07	1470	86	21	int:TOP3B
Interaction	UGT1A9 interactions	UGT1A10 UGT1A7 UGT1A9	2.08e-05	13	86	3	int:UGT1A9
Cytoband	2q37	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.99e-07	31	89	4	2q37
Cytoband	Ensembl 112 genes in cytogenetic band chr2q37	UGT1A10 UGT1A8 UGT1A7 PRSS56 UGT1A9	8.20e-05	226	89	5	chr2q37
GeneFamily	UDP glucuronosyltransferases	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.93e-06	32	61	4	363
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	SH2B3 PLEKHG4 GRB14 PLEKHH2 SOS2	6.48e-04	206	61	5	682
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG4 ARHGEF11 SOS2	1.44e-03	66	61	3	722
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	TAOK2 MAP3K6	2.95e-03	24	61	2	654
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MPL SH2B3 GATA2 SLFN14 LYST GP1BA	1.56e-06	180	88	6	ca2a35bfb67347e47f511589a3d0f763e6664634
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MPL SH2B3 GATA2 SLFN14 LYST GP1BA	1.56e-06	180	88	6	4e9e8cde2919610c4ac0025b1c9819808048bc1d
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MPL SH2B3 GATA2 SLFN14 LYST GP1BA	1.56e-06	180	88	6	466381bf93c3da6a2a241daadb68e9aad2964eae
ToppCell	Healthy/Control-Platelet\|World / Disease group and Cell class	MGAT4B GATA2 DIPK1B GRB14 SLFN14 GP1BA	2.00e-06	188	88	6	552077e4597d0956f4d8c40c9de8f109e87cb857
ToppCell	Healthy/Control-Platelet\|Healthy/Control / Disease group and Cell class	MGAT4B GATA2 DIPK1B GRB14 SLFN14 GP1BA	2.07e-06	189	88	6	3de7f8d8b8451ed9a146cce499552e9a060e9099
ToppCell	Globus_pallidus\|World / BrainAtlas - Mouse McCarroll V32	ESYT3 TPCN2 PLEKHG4 TMEM86B INVS	5.17e-06	126	88	5	44b63f945d5bedf1a2ca1810e7e100276ea9dd89
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GATA2 DIPK1B GRB14 SLFN14 GP1BA	2.09e-05	168	88	5	2d056cfbb470a088a0682576753535fb4528d48f
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GATA2 DIPK1B GRB14 SLFN14 GP1BA	2.09e-05	168	88	5	2f69e248c6fab1421c0081e01e1920e6ffcde344
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GATA2 DIPK1B GRB14 SLFN14 GP1BA	3.31e-05	185	88	5	9bff336510c80cd762b4e41b4570475033e709ca
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GATA2 DIPK1B GRB14 SLFN14 GP1BA	3.31e-05	185	88	5	452d49c7835a4d55e41caefa44dac5cab30e7ced
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic-Megakaryocytic-Megakaryocyte\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GATA2 DIPK1B GRB14 SLFN14 GP1BA	3.31e-05	185	88	5	53f5136ee1bd101dd5ac8a2c9e63b0c3b987657e
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPL ANKK1 FREM2 REXO5 SYT10	3.31e-05	185	88	5	05bc89a566b0db90ae06506e067190a4739a0974
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic-Megakaryocytic\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GATA2 DIPK1B GRB14 SLFN14 GP1BA	3.31e-05	185	88	5	67ac5c2bacdbdcb40ee65c44da55b3f597b410ee
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Hematopoietic-Megakaryocytic-Megakaryocyte\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GATA2 DIPK1B GRB14 SLFN14 GP1BA	3.40e-05	186	88	5	9e2e8e2c3de711734cdb4775bafb0757b4db97b1
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GATA2 DIPK1B GRB14 SLFN14 GP1BA	3.40e-05	186	88	5	107bc473f5e57238390f8e0ab9f7263a8f93948c
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GATA2 DIPK1B GRB14 SLFN14 GP1BA	3.40e-05	186	88	5	8fbf5cb31192066b4c202f80baf6d7f2bdefedb9
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GATA2 DIPK1B GRB14 SLFN14 GP1BA	3.40e-05	186	88	5	13a9ddcf93b0c4319ab9d484af5e2056e9754caa
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Hematopoietic\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GATA2 DIPK1B GRB14 SLFN14 GP1BA	3.40e-05	186	88	5	1dfd3fc4012bf0254adfa1f5eddadc9b6107455b
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Hematopoietic-Megakaryocytic\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GATA2 DIPK1B GRB14 SLFN14 GP1BA	3.40e-05	186	88	5	49d23c985b2f5e16790f4d7ccf81ef7b794c0877
ToppCell	Healthy_donor-Platelet\|Healthy_donor / disease group, cell group and cell class (v2)	GATA2 DIPK1B GRB14 SLFN14 GP1BA	3.48e-05	187	88	5	9040ffa5c23913b9dc0205fa6227223c2a2847ae
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Slc17a6-Inhibitory_Neuron.Slc17a6-Gad1Gad2.Asb4_(Periventricular_Fiber_System_(Pv))\|Thalamus / BrainAtlas - Mouse McCarroll V32	ESYT3 HTR6 SLC10A4 PRSS56	3.64e-05	94	88	4	82e9178c848468497295c4cc59c662b9279208a1
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Slc17a6-Inhibitory_Neuron.Slc17a6-Gad1Gad2.Asb4_(Periventricular_Fiber_System_(Pv))-\|Thalamus / BrainAtlas - Mouse McCarroll V32	ESYT3 HTR6 SLC10A4 PRSS56	3.64e-05	94	88	4	be1dcfe287f58d608ccdb47cf9c1d12b5e3aa60d
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Slc17a6\|Thalamus / BrainAtlas - Mouse McCarroll V32	ESYT3 HTR6 SLC10A4 PRSS56	3.64e-05	94	88	4	576c37fa53fab679f5e8786f5c798e18998186e9
ToppCell	Healthy_donor-Platelet\|World / disease group, cell group and cell class (v2)	MGAT4B GATA2 DIPK1B GRB14 GP1BA	3.85e-05	191	88	5	defae87313d6345e3f451250fd66fe8831bb441c
ToppCell	Control-Control-Others-Platelet\|Control / Disease, condition lineage and cell class	MGAT4B GATA2 DIPK1B GRB14 GP1BA	4.79e-05	200	88	5	e0463c93714ab5fd00f294cca83bd61027fe0e95
Drug	naringenin chalcone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.04e-09	5	88	4	ctd:C027329
Drug	anthrarobin	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.04e-09	5	88	4	ctd:C032186
Drug	1,2,5,8-tetrahydroxy anthraquinone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.11e-09	6	88	4	ctd:C543211
Drug	alloin	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.11e-09	6	88	4	ctd:C006457
Drug	2',5'-dihydroxychalcone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.11e-09	6	88	4	ctd:C107497
Drug	3 beta,5 alpha,25R)- 3-hydroxyspirostan-12-one	UGT1A10 UGT1A8 UGT1A7 UGT1A9 GP1BA	4.59e-09	17	88	5	CID000003573
Drug	2',4'-dihydroxychalcone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.23e-09	7	88	4	ctd:C059354
Drug	5alpha-spirostan-3beta-ol	UGT1A10 UGT1A8 UGT1A7 UGT1A9 GP1BA	8.57e-09	19	88	5	CID000091433
Drug	1,4-dihydroxyanthraquinone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.44e-08	8	88	4	ctd:C034890
Drug	AC1MRQNQ	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.59e-08	9	88	4	CID003522271
Drug	DHPASiU	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.59e-08	9	88	4	CID000197602
Drug	3-iodophenol	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.59e-08	9	88	4	CID000012272
Drug	AC1L4J7U	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.59e-08	9	88	4	CID000186631
Drug	Chebi:32663	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.59e-08	9	88	4	CID005460873
Drug	2,6-dihydroxyanthraquinone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.30e-08	10	88	4	ctd:C034889
Drug	4-nitrophenyl)imidazole	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.73e-08	11	88	4	CID000123155
Drug	AC1O5XMV	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.73e-08	11	88	4	CID006442661
Drug	norclozapine	HTR6 UGT1A10 UGT1A8 UGT1A7 CLN3 UGT1A9	8.69e-08	57	88	6	CID000002820
Drug	N-OH-DABZ	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.01e-07	12	88	4	CID000051366
Drug	1-O-beta-D-glucopyranosyl-D-mannitol	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.01e-07	12	88	4	CID000088735
Drug	4-hydroxyestrone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.01e-07	12	88	4	ctd:C026418
Drug	2,4,6-TCB	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.01e-07	12	88	4	CID000037247
Drug	nonanoyl-N-methylglucamide	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.01e-07	12	88	4	CID000160090
Drug	7,7,7-triphenylheptanoic acid	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.01e-07	12	88	4	CID000276709
Drug	urochloralic acid	UGT1A10 UGT1A8 PDP1 UGT1A7 UGT1A9 LYST	1.07e-07	59	88	6	CID003036914
Drug	2-hydroxyestrone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.45e-07	13	88	4	ctd:C024980
Drug	tritanol	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.45e-07	13	88	4	CID000006457
Drug	5-azido-UDP-glucuronic acid	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.45e-07	13	88	4	CID003081279
Drug	cotinine-N-glucuronide	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.45e-07	13	88	4	CID000000411
Drug	alizarin	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.45e-07	13	88	4	ctd:C010078
Drug	propranolol glucuronide	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.02e-07	14	88	4	CID000119515
Drug	PCB-61	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.02e-07	14	88	4	CID000036401
Drug	hydratropic acid	UGT1A10 UGT1A8 UGT1A7	2.23e-07	4	88	3	ctd:C013025
Drug	2-vanillin	UGT1A10 UGT1A8 UGT1A7	2.23e-07	4	88	3	ctd:C060843
Drug	diphenylacetic acid	UGT1A10 UGT1A8 UGT1A7	2.23e-07	4	88	3	ctd:C037760
Drug	2,2',3,5,5'-pentachlorobiphenyl	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.75e-07	15	88	4	CID000040469
Drug	afloqualone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.75e-07	15	88	4	CID000002040
Drug	naphthyl sulphate	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.75e-07	15	88	4	CID000114775
Drug	coumarin-3-carboxylic acid	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.75e-07	15	88	4	CID000010752
Drug	bergamottin	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.75e-07	15	88	4	ctd:C068337
Drug	sulforaphane nitrile	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.75e-07	15	88	4	CID000543743
Drug	quercetin-3,4'-diglucoside	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.66e-07	16	88	4	CID005320835
Drug	1'-hydroxyestragole	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.66e-07	16	88	4	CID000040003
Drug	bilirubin-phosphate	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.66e-07	16	88	4	CID005497144
Drug	6-hydroxychrysene	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.77e-07	17	88	4	CID000037766
Drug	isovaleric acid	UGT1A10 UGT1A8 UGT1A7	5.55e-07	5	88	3	ctd:C008216
Drug	biphenylylacetic acid	UGT1A10 UGT1A8 UGT1A7	5.55e-07	5	88	3	ctd:C012776
Drug	SureCN12722713	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.12e-07	18	88	4	CID005488034
Drug	ethyl-beta-D-6-glucosiduronic acid	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.12e-07	18	88	4	CID000152226
Drug	Br 2	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.12e-07	18	88	4	CID003060900
Drug	2,3,7-trichlorodibenzo-p-dioxin	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.12e-07	18	88	4	CID000036614
Drug	ApApG	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.12e-07	18	88	4	CID003081975
Drug	C1 11-32	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.12e-07	18	88	4	CID000443077
Drug	C11131	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.12e-07	18	88	4	CID000443076
Drug	9-OH-risperidone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.72e-07	19	88	4	CID000475100
Drug	almokalant	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.72e-07	19	88	4	CID003033962
Drug	tectochrysin	UGT1A10 UGT1A8 UGT1A7 UGT1A9	9.63e-07	20	88	4	CID005281954
Drug	AC1L1OBF	UGT1A10 UGT1A8 UGT1A7 UGT1A9	9.63e-07	20	88	4	CID000032736
Drug	4'-hydroxydiclofenac	UGT1A10 UGT1A8 UGT1A7 UGT1A9	9.63e-07	20	88	4	CID000116545
Drug	entacapone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	9.63e-07	20	88	4	ctd:C071192
Drug	3-phenylpropionic acid	UGT1A10 UGT1A8 UGT1A7	1.11e-06	6	88	3	ctd:C035253
Drug	Indoprofen	UGT1A10 UGT1A8 UGT1A7	1.11e-06	6	88	3	ctd:D007216
Drug	estriol-16-glucuronide	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.19e-06	21	88	4	CID000122281
Drug	dulcin	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.19e-06	21	88	4	CID000009013
Drug	Benzamidoxime hydrochloride	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.19e-06	21	88	4	CID000069186
Drug	amitriptyline	HTR6 UGT1A10 UGT1A8 PDP1 UGT1A7 HTR3E UGT1A9	1.20e-06	140	88	7	CID000002160
Drug	amonafide	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.44e-06	22	88	4	CID000050515
Drug	N-methylpiperazine	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.44e-06	22	88	4	CID000053167
Drug	plumbagin	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.44e-06	22	88	4	ctd:C014758
Drug	amidoxime	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.74e-06	23	88	4	CID000465967
Drug	estradiol-3-glucuronide	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.74e-06	23	88	4	CID000066651
Drug	phenanthridine	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.74e-06	23	88	4	CID000009189
Drug	ASA404	ADAMTS2 UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.91e-06	53	88	5	CID000123964
Drug	cyproheptadine	HTR6 UGT1A10 UGT1A8 UGT1A7 HTR3E UGT1A9	1.97e-06	96	88	6	CID000002913
Drug	AS-3201	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.09e-06	24	88	4	CID000153948
Drug	5-MOP	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.48e-06	25	88	4	CID000002355
Drug	Hymecromone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.48e-06	25	88	4	ctd:D006923
Drug	AzMC	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.48e-06	25	88	4	CID000064986
Drug	N-acetylbenzidine	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.48e-06	25	88	4	CID000018787
Drug	5,6-benzoquinoline	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.48e-06	25	88	4	CID000006796
Drug	N-phenylmaleimide	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.48e-06	25	88	4	CID000013662
Drug	Thymol	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.92e-06	26	88	4	ctd:D013943
Drug	glabridin	UGT1A10 UGT1A8 UGT1A9	3.08e-06	8	88	3	ctd:C107601
Drug	4-hydroxybiphenyl	UGT1A10 UGT1A8 UGT1A7 CLN3 UGT1A9	3.27e-06	59	88	5	CID000007103
Drug	licochalcone A	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.42e-06	27	88	4	ctd:C070840
Drug	diflunisal	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.42e-06	27	88	4	CID000003059
Drug	Scopoletin	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.42e-06	27	88	4	ctd:D012603
Drug	DiMeIQx	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.42e-06	27	88	4	CID000104739
Drug	CARMINE	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.97e-06	28	88	4	CID000014749
Drug	erucin	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.97e-06	28	88	4	CID000078160
Drug	N-hydroxy-4-aminobiphenyl	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.97e-06	28	88	4	CID000081261
Drug	H-Ni	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.97e-06	28	88	4	CID000445665
Drug	NSC740136	ADAM15 UGT1A10 UGT1A8 UGT1A7 UGT1A9 LYST	4.13e-06	109	88	6	CID000003706
Drug	AC1L1JAL	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.60e-06	29	88	4	CID000004954
Drug	7-hydroxycoumarin glucuronide	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.60e-06	29	88	4	CID000125641
Drug	7-hydroxy-4-trifluoromethylcoumarin	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.60e-06	29	88	4	CID005375667
Drug	trans-3'-hydroxycotinine	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.60e-06	29	88	4	CID000000414
Drug	iberin	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.60e-06	29	88	4	CID000010455
Drug	2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.60e-06	29	88	4	ctd:C060533
Drug	tolcapone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.29e-06	30	88	4	CID004659569
Disease	N-acetyl-4-chlorophenylalanine measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.20e-10	5	85	4	EFO_0801060
Disease	5-hydroxyindole sulfate measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.20e-10	5	85	4	EFO_0800085
Disease	nuclear receptor subfamily 1 group D member 2 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.20e-10	5	85	4	EFO_0801853
Disease	X-21339 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.23e-09	7	85	4	EFO_0800808
Disease	X-11793--oxidized bilirubin measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.45e-09	8	85	4	EFO_0021260
Disease	Succinimide measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.45e-09	8	85	4	EFO_0022118
Disease	X-11530 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.45e-09	8	85	4	EFO_0021249
Disease	sulfate of piperine metabolite C16H19NO3 (2) measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.45e-09	8	85	4	EFO_0801034
Disease	cholelithiasis, bilirubin measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.45e-09	8	85	4	EFO_0004570, EFO_0004799
Disease	X-11522 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.45e-09	8	85	4	EFO_0800696
Disease	X-10458 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.45e-09	8	85	4	EFO_0800692
Disease	X-24849 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.45e-09	8	85	4	EFO_0800909
Disease	serum N-desmethylclozapine measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.45e-09	8	85	4	EFO_0600043
Disease	plasma clozapine measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.45e-09	8	85	4	EFO_0600038
Disease	membrane-associated progesterone receptor component 1 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.45e-09	8	85	4	EFO_0802740
Disease	X-16946 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.45e-09	8	85	4	EFO_0800766
Disease	X-11442 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.99e-09	9	85	4	EFO_0021236
Disease	X-11441 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.99e-09	9	85	4	EFO_0021235
Disease	circulating cell free DNA measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.99e-09	9	85	4	EFO_0004739
Disease	sulfate of piperine metabolite C18H21NO3 (3) measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.99e-09	9	85	4	EFO_0801037
Disease	testis-specific chromodomain protein Y 1 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.99e-09	9	85	4	EFO_0802127
Disease	sulfate of piperine metabolite C18H21NO3 (1) measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.99e-09	9	85	4	EFO_0801036
Disease	X-11880 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.99e-09	9	85	4	EFO_0800698
Disease	bilirubin measurement, response to xenobiotic stimulus	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.99e-09	9	85	4	EFO_0004570, GO_0009410
Disease	protein-tyrosine kinase 6 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.99e-09	9	85	4	EFO_0020691
Disease	X-21448 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.33e-08	10	85	4	EFO_0800816
Disease	UDP-glucuronosyltransferase 1-6 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.33e-08	10	85	4	EFO_0802185
Disease	X-23974 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.33e-08	10	85	4	EFO_0800867
Disease	bilirubin measurement, response to tenofovir	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.33e-08	10	85	4	EFO_0004570, EFO_0009279
Disease	X-21796 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.08e-08	11	85	4	EFO_0800825
Disease	pregnenetriol sulfate measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.08e-08	11	85	4	EFO_0800586
Disease	plasma N-desmethylclozapine measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.08e-08	11	85	4	EFO_0600039
Disease	insomnia, bilirubin measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.08e-08	11	85	4	EFO_0004570, EFO_0004698
Disease	histidine betaine (hercynine) measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.08e-08	11	85	4	EFO_0800972
Disease	aldosterone measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.08e-08	11	85	4	EFO_0010219
Disease	blood 4-oxo-retinoic acid measurement	UGT1A10 UGT1A8 UGT1A9	2.31e-08	3	85	3	EFO_0022216
Disease	indole-3-carboxylate measurement	UGT1A10 UGT1A8 UGT1A9	2.31e-08	3	85	3	EFO_0800043
Disease	biliverdin measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.12e-08	12	85	4	EFO_0021033
Disease	p-cresol glucuronide measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.12e-08	12	85	4	EFO_0800079
Disease	retinol dehydrogenase 16 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.49e-08	13	85	4	EFO_0802007
Disease	pregnenetriol disulfate measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.49e-08	13	85	4	EFO_0800587
Disease	X-21441 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.48e-07	17	85	4	EFO_0800814
Disease	low density lipoprotein cholesterol measurement, body fat percentage	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.48e-07	17	85	4	EFO_0004611, EFO_0007800
Disease	angiopoietin-related protein 1 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.90e-07	18	85	4	EFO_0801382
Disease	tissue factor measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.70e-07	21	85	4	EFO_0010623
Disease	3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-CMPFP) measurement	UGT1A10 UGT1A8 UGT1A9	4.59e-07	6	85	3	EFO_0800566
Disease	neuroblastoma, cutaneous melanoma	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.25e-06	28	85	4	EFO_0000389, EFO_0000621
Disease	xanthurenate measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.44e-06	29	85	4	EFO_0010551
Disease	response to dolutegravir	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.66e-06	30	85	4	EFO_0600017
Disease	indoleacetate measurement	UGT1A10 UGT1A8 UGT1A9	2.73e-06	10	85	3	EFO_0021015
Disease	vitamin D deficiency	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.94e-06	37	85	4	EFO_0003762
Disease	X-24588 measurement	UGT1A10 UGT1A8 UGT1A9	6.46e-06	13	85	3	EFO_0800898
Disease	vitamin D measurement, COVID-19	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.23e-05	49	85	4	EFO_0004631, MONDO_0100096
Disease	urate measurement, spine bone mineral density	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.42e-05	58	85	4	EFO_0004531, EFO_0007701
Disease	nt-3 growth factor receptor measurement	SH2B3 NTRK3	2.46e-05	3	85	2	EFO_0020613
Disease	non-high density lipoprotein cholesterol measurement	SH2B3 ADAM15 UGT1A10 UGT1A8 UGT1A7 FBRSL1 UGT1A9 GRB14 GLTPD2 MAP3K6	3.90e-05	713	85	10	EFO_0005689
Disease	MYELODYSPLASTIC SYNDROME	MPL FANCC SH2B3 GATA2	4.28e-05	67	85	4	C3463824
Disease	MYELOFIBROSIS	MPL SH2B3	4.90e-05	4	85	2	254450
Disease	Primary myelofibrosis	MPL SH2B3	4.90e-05	4	85	2	cv:C0001815
Disease	Essential thrombocythemia	MPL SH2B3	8.15e-05	5	85	2	cv:C0040028
Disease	thyroxine measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	9.91e-05	83	85	4	EFO_0005130
Disease	hormone measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.04e-04	84	85	4	EFO_0004730
Disease	Primary Myelofibrosis	MPL SH2B3	1.22e-04	6	85	2	C0001815
Disease	essential thrombocythemia (is_implicated_in)	MPL SH2B3	1.22e-04	6	85	2	DOID:2224 (is_implicated_in)
Disease	cholelithiasis	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.24e-04	88	85	4	EFO_0004799
Disease	myelofibrosis (is_implicated_in)	MPL SH2B3	2.27e-04	8	85	2	DOID:4971 (is_implicated_in)
Disease	Polycythemia Vera	MPL SH2B3	2.27e-04	8	85	2	C0032463
Disease	gallstones	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.74e-04	108	85	4	EFO_0004210
Disease	glycolipid transfer protein domain-containing protein 2 measurement	ZMYND15 GLTPD2	2.91e-04	9	85	2	EFO_0801643
Disease	platelet crit	MPL MGAT4B SH2B3 CLN3 GATA2 USP7 SLFN14 ARHGEF11 EPHX3 GP1BA	4.09e-04	952	85	10	EFO_0007985
Disease	dodecanedioate measurement	UGT1A10 UGT1A8	5.31e-04	12	85	2	EFO_0021054
Disease	Hematologic Neoplasms	MPL SH2B3	5.31e-04	12	85	2	C0376545
Disease	Thrombocythemia, Essential	MPL SH2B3	5.31e-04	12	85	2	C0040028
Disease	Alopecia, Male Pattern	ZDHHC13 HR	8.40e-04	15	85	2	C4083212
Disease	Androgenetic Alopecia	ZDHHC13 HR	8.40e-04	15	85	2	C0162311
Disease	Female pattern alopecia (disorder)	ZDHHC13 HR	8.40e-04	15	85	2	C0263477
Disease	type 2 diabetes mellitus (biomarker_via_orthology)	UGT1A10 UGT1A8 UGT1A7 UGT1A9	8.75e-04	147	85	4	DOID:9352 (biomarker_via_orthology)
Disease	Benign neoplasm of stomach	POLE MUTYH	1.08e-03	17	85	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	POLE MUTYH	1.08e-03	17	85	2	C0496905
Disease	Carcinoma in situ of stomach	POLE MUTYH	1.08e-03	17	85	2	C0154060
Disease	Pseudopelade	ZDHHC13 HR	1.36e-03	19	85	2	C0086873
Disease	Juvenile Myelomonocytic Leukemia	SH2B3 GATA2	1.36e-03	19	85	2	C0349639
Disease	Alopecia	ZDHHC13 HR	1.36e-03	19	85	2	C0002170
Disease	Leukemia, Myelocytic, Acute	FANCC SH2B3 NTRK3 GATA2	1.60e-03	173	85	4	C0023467
Disease	Stomach Carcinoma	POLE MUTYH	1.66e-03	21	85	2	C0699791
Disease	bilirubin measurement	SH2B3 UGT1A10 UGT1A8 UGT1A7 UGT1A9 SOS2	1.76e-03	442	85	6	EFO_0004570

Protein segments in the cluster

Peptide	Gene	Start	Entry
DPLAWGHSAHLLSRP	MAMDC4	701	Q6UXC1
LRGQHLPAWIHFPDV	ESYT3	101	A0FGR9
LPSPHEAWNRLHRAP	FBRSL1	726	Q9HCM7
PLLLGWHELGHARPP	HTR6	161	P50406
GIHREHLPLPSTRAW	CCDC187	1031	A0A096LP49
CSWAPPHLQRHLPLA	CAPS	41	Q13938
PPLPRWLHSLLLHCN	HTR3E	341	A5X5Y0
HWRRAHLLPRLPHDS	ADAM15	286	Q13444
GLLQLLLHWLHPCPL	CDCP2	411	Q5VXM1
LELPTHQGWTPLHLA	ANKK1	586	Q8NFD2
ENLRHLILWSLLPGH	ARHGEF11	1206	O15085
LRAPSHHAQLGPVWA	CFAP46	2571	Q8IYW2
HALWTGRLPLPWRPH	DNHD1	4526	Q96M86
HGAWHAAALPPLLRP	DIPK1B	236	Q5VUD6
FAHDWPALPQLPGLH	ADAMTS2	471	O95450
EHDHLHLLPNGSLWL	IGDCC4	81	Q8TDY8
HLPGLPIWIRIGVHS	GUCY2C	911	P25092
PHALPFWDTPLNHGL	SLC10A4	91	Q96EP9
HIDLSHNPWLRRVHP	LRRC55	141	Q6ZSA7
ALGPHHPWLVRQTAR	GLTPD2	221	A6NH11
DPRLKPWNGSHRHVL	MGAT4B	96	Q9UQ53
PTLHWLHNGQPLRES	NTRK3	331	Q16288
PLALPAHGLWSRHIL	NAB2	441	Q15742
VLRLPDLALNDGHWH	CRB2	506	Q5IJ48
HPPHEKQELLRGLWR	FREM2	616	Q5SZK8
AGGSRLLPHLHWNAP	MCM3AP	1641	O60318
ILVHADTPLPAWHRA	HR	1016	O43593
GPPRRAHFWLHFLLQ	MAP3K6	496	O95382
GLPEAQHGFHLLWQR	KPTN	346	Q9Y664
ALPHPHLLWRDCSRG	OR2W5P	211	A6NFC9
HLWPFTIHDLRALGA	MICAL1	126	Q8TDZ2
LTPLHWAAALGHTLL	ANKRD65	141	E5RJM6
NHLLWLSPTARPDLG	POLE	1681	Q07864
GWRLGNWLHKHPHPN	KLLN	126	B2CW77
ESGRALLPILQWHKH	PDP1	181	Q9P0J1
ALCPRLWDVPLHHLS	PLCXD1	26	Q9NUJ7
GLFLPHHPFLWLLRL	PLEKHH2	1051	Q8IVE3
PFTPLGWHHNNLELL	PIKFYVE	581	Q9Y2I7
RPHLLHSPGLPWLDG	GATA2	86	P23769
PAHSISPLLQFRWGH	FER1L6-AS2	121	Q96M78
LHDLLHPDLALAGDW	CACNA2D4	671	Q7Z3S7
IDSLPLPRKAHHDWA	FUT10	131	Q6P4F1
IWESFPHQALLRQHP	DIS3L	696	Q8TF46
AAFHWSLLGPEHPLA	FAM120C	326	Q9NX05
PQDIPRGHWLQTLKH	FANCC	356	Q00597
WHIAPVHLPLLGQNC	LYST	1451	Q99698
VHLPLLGQNCWPHLS	LYST	1456	Q99698
RLEAHILPGIGHWIP	EPHX3	326	Q9H6B9
HLLPFAFLHGNPWLC	GP1BA	211	P07359
AHDLAPAPWLHARAL	GRB14	36	Q14449
GALSLLQHLRPHWDP	ETNK1	121	Q9HBU6
HPHALAGRPGLRLLW	HELZ2	1781	Q9BYK8
RPLGPHGLDWLKIHL	POLRMT	831	O00411
NTLGILGPLDHHWLV	CNOT6	501	Q9ULM6
LLLLPLPSSWFAHGH	PRSS56	6	P0CW18
RTPLHWAALLGHAQI	INVS	256	Q9Y283
LHAERRGPQPWHAAL	MMP11	41	P24347
SENLHHGILWLFLDP	SLFN14	691	P0C7P3
PPPLGHLHRDSDWLR	SOS2	1236	Q07890
PDWLLDVSHLVAPHA	TMEM132A	571	Q24JP5
HAELHPSSFWLRGLL	RHOT2	581	Q8IXI1
LQLHWTRHPDLPPAH	PLEKHG4	591	Q58EX7
VLLAHNPHRDLGIFW	GANAB	301	Q14697
HAHLDTGRREPWLLP	GANAB	676	Q14697
LLPQPLAGHAAWGIH	PRORY	56	Q9H606
PWLISLLNSFHPHEE	SMG7	391	Q92540
QGLASHLPPWAIHTL	TAOK2	1166	Q9UL54
LQRWAGPLPATHLRH	MUTYH	421	Q9UIF7
LLAALLGHWEASRHP	INTS5	881	Q6P9B9
WQPPHFAHLPLLLNR	EARS2	266	Q5JPH6
PEPRLPLLDHQGAHW	CLN3	21	Q13286
KGAPHLRPAAHDLTW	UGT1A10	466	Q9HAW8
NSTPLHWAIRQGHLP	ZDHHC13	116	Q8IUH4
RLSPHHWEKSPLLQE	ZNF174	186	Q15697
HHLTVPAIRWLGLLP	SPO11	301	Q9Y5K1
WLHSVPHVGLRLQPV	TTYH2	16	Q9BSA4
RHLHAWLRGLPPEST	REXO5	676	Q96IC2
GLLHGVAPWRSSLHP	PISD	11	Q9UG56
IPHHAPVLLAWALLR	NUP188	316	Q5SRE5
WLFAREHPQHAPLRA	SH2B3	46	Q9UQQ2
LAWDTFAQPLPHAHL	TMEM86B	186	Q8N661
HALWPSLPDLHRVLG	MPL	526	P40238
KGAPHLRPAAHDLTW	UGT1A9	466	O60656
PITHWHPLLELPGRA	SYT10	491	Q6XYQ8
LPGELRTWVQLHHPE	ZKSCAN7	106	Q9P0L1
LHIDEILSHSWLQPP	TSSK2	261	Q96PF2
SHPRPWLGLDHFNKA	USP7	1071	Q93009
AWLLGDNPPLHLRDL	ZMYND15	86	Q9H091
NFLHKWDPRSHLQPL	TPCN2	696	Q8NHX9
KGAPHLRPAAHDLTW	UGT1A7	466	Q9HAW7
KGAPHLRPAAHDLTW	UGT1A8	466	Q9HAW9