Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	actin binding	SPATA31A1 SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7 VASH1	1.38e-04	479	48	7	GO:0003779
GeneOntologyCellularComponent	acrosomal vesicle	SPATA31A1 SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	7.40e-06	206	48	6	GO:0001669
Domain	DUF4599	SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	6.33e-11	12	47	5	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	6.33e-11	12	47	5	IPR027970
Domain	FCH	ARHGAP4 FCHSD1	1.39e-03	22	47	2	PF00611
Domain	FCH	ARHGAP4 FCHSD1	1.39e-03	22	47	2	SM00055
Domain	FCH_dom	ARHGAP4 FCHSD1	1.52e-03	23	47	2	IPR001060
Domain	F_BAR	ARHGAP4 FCHSD1	1.79e-03	25	47	2	IPR031160
Domain	F_BAR	ARHGAP4 FCHSD1	1.79e-03	25	47	2	PS51741
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A1 SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	4.99e-18	6	48	6	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A1 SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	4.99e-18	6	48	6	25930072
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A1 SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	6.60e-13	24	48	6	32212159
Pubmed	UBR5 is a novel regulator of WNK1 stability.	WNK1 UBR5	1.87e-06	2	48	2	35442829
Pubmed	Nuclear factor Y and steroidogenic factor 1 physically and functionally interact to contribute to cell-specific expression of the mouse Follicle-stimulating hormone-beta gene.	NFYA NR5A1	1.12e-05	4	48	2	12730328
Pubmed	Oligomerization but Not Membrane Bending Underlies the Function of Certain F-BAR Proteins in Cell Motility and Cytokinesis.	ARHGAP4 FCHSD1	2.79e-05	6	48	2	26702831
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	EPB41L5 CHD6 DDX46 UBR5 EXOSC4 NUP153 RPL17	3.07e-05	655	48	7	35819319
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	KIAA1549 RADIL INPP5F WNK1 UBR5 CEP89	3.35e-05	446	48	6	24255178
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	INTS10 CHD6 DDX46 L3MBTL2 EXOSC4 NUP153 RRP1 RPL17 RBM17	6.02e-05	1294	48	9	30804502
Pubmed	Steroidogenic factor 1 differentially regulates fetal and adult leydig cell development in male mice.	NR5A1 RPL17	1.02e-04	11	48	2	26269506
Pubmed	The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.	L3MBTL2 EXOSC4 RRP1 RPL17 RBM17	2.71e-04	417	48	5	36537216
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	CHD6 INPP5F L3MBTL2 UBR5 PIAS2	2.74e-04	418	48	5	34709266
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	OTUD4 DDX46 WNK1 UBR5	3.13e-04	235	48	4	30258100
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	EPB41L5 KIAA1549 ZNF317	3.74e-04	101	48	3	10997877
Pubmed	Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis.	UBR5 RBM17	3.85e-04	21	48	2	30179224
Pubmed	A human MAP kinase interactome.	NFYA CHD6 WNK1 PIAS2 NUP153	5.45e-04	486	48	5	20936779
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	DDX46 DNAJA4 NUP153 RPL17 RBM17	6.54e-04	506	48	5	30890647
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	EPB41L5 KIAA1549 L3MBTL2 UBR5 CEP89 DNAJA4 RRP1 RPL17	9.00e-04	1487	48	8	33957083
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EPB41L5 INTS10 OTUD4 CHD6 DDX46 EXOSC4 PPP1R12B RRP1	9.39e-04	1497	48	8	31527615
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	DDX46 L3MBTL2 UBR5 DNAJA4 NUP153 PPP1R12B RBM17	9.80e-04	1155	48	7	20360068
Pubmed	Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.	DDX46 RBM17	1.02e-03	34	48	2	12234937
Pubmed	Many sequence variants affecting diversity of adult human height.	SMPD2 DDX46 NUP153	1.03e-03	143	48	3	18391951
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	DDX46 EXOSC4 NUP153 RRP1 RPL17 RBM17	1.05e-03	847	48	6	35850772
Pubmed	Nuclear Functions of Nucleolin through Global Proteomics and Interactomic Approaches.	EXOSC4 RRP1 RPL17	1.07e-03	145	48	3	27049334
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A5 SPATA31A7	2.99e-05	8	48	2	chr9q12
Cytoband	9p13.1	SPATA31A1 SPATA31A3	2.91e-04	24	48	2	9p13.1
Cytoband	11q22.3	CWF19L2 PDGFD	9.85e-04	44	48	2	11q22.3
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	ARHGAP4 FCHSD1	7.50e-04	23	32	2	1288
Disease	gonadal dysgenesis (implicated_via_orthology)	STARD13 NR5A1	1.13e-05	4	41	2	DOID:14447 (implicated_via_orthology)
Disease	progression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian carcinoma	INTS10 EPHA6 RBM17	2.20e-05	39	41	3	EFO_0001075, EFO_0004920, GO_0097328, MONDO_0009354
Disease	response to calcium channel blocker	KCNK3 ELOVL6	2.77e-03	56	41	2	EFO_0007767
Disease	response to angiotensin-converting enzyme inhibitor	KCNK3 OTUD4	5.29e-03	78	41	2	EFO_0005325

Protein segments in the cluster

Peptide	Gene	Start	Entry
LRPRERFRGMERMHG	EXOC3L4	586	Q17RC7
IHRMRRMGSASRKGR	BNC2	426	Q6ZN30
GGRMARERRGKNVVH	DNAJA4	96	Q8WW22
KHRRRERRFGRDMET	CAPN1	426	P07384
HVGDRKGSRRRMDTE	OTUD4	496	Q01804
KGRRSYGDILHRMKD	INTS10	276	Q9NVR2
GDTKERHRVYRRAQM	KIAA1549	1556	Q9HCM3
RAVDLIRHGGKKMRF	RADIL	1041	Q96JH8
RKRRPHGDRKSCEMG	EXOSC4	86	Q9NPD3
SRRVGHGIKMSERRS	L3MBTL2	381	Q969R5
VRYLLHRAKKGLGMR	KCNK3	136	O14649
HRAKKGLGMRRADVS	KCNK3	141	O14649
GHIKRRGRAKTMALV	PDGFD	336	Q9GZP0
GGRRKRQMVSTHEER	CWF19L2	571	Q2TBE0
KRRLLMGTRSRAQGH	KDM4E	476	B2RXH2
YLSKHRADRMRRLGD	SMPD2	21	O60906
KREGHRSGEMDSRGR	FCHSD1	66	Q86WN1
GGRHLMNKRAKFELR	ELOVL6	46	Q9H5J4
RRTLGRRSMRKHAEK	EPB41L5	6	Q9HCM4
RRRGRRKHVEGGMDL	CHD6	2286	Q8TD26
MLLGFRRGRRSHFKH	CEP89	1	Q96ST8
MGRESRHYRKRSASR	DDX46	1	Q7L014
ISRRSRHRAGMRYKR	INPP5F	281	Q9Y2H2
RHRAGMRYKRRGVDK	INPP5F	286	Q9Y2H2
RLDHGGHLEMRKARG	SLC38A10	976	Q9HBR0
AGRNKSGRKHDLLMR	PIAS2	26	O75928
ESRHRHAMARKRGEG	NFYA	301	P23511
KGGHMDRQRRDFLRE	EPHA6	666	Q9UF33
KRMETLRGKGAHGRH	STARD13	261	Q9Y3M8
EAVRADRMRGGRNKF	NR5A1	81	Q13285
RPRGRMKNHSLRAGR	SPATA31A6	71	Q5VVP1
RPRGRMKNHSLRAGR	SPATA31A7	71	Q8IWB4
MERKRSRRRGVGADP	RRP1	386	P56182
KAPKMRRRTYRAHGR	RPL17	121	P18621
RGRPRGRMKNHSLRA	SPATA31C1	81	P0DKV0
MAAHGKLRRERGLQA	ARHGAP4	1	P98171
RPRGRMKNHSLRAGR	SPATA31A3	71	Q5VYP0
MKNHSLRAGRECRRG	SPATA31A3	76	Q5VYP0
RPRGRMKNHSLRAGR	SPATA31A1	71	Q5TZJ5
RPRGRMKNHSLRAGR	SPATA31A5	71	Q5VU36
MKNHSLRAGRECRRG	SPATA31A5	76	Q5VU36
YERERRKRSMGGAAI	RBM17	161	Q96I25
EKSRLFMDARHKRGR	WNT6	181	Q9Y6F9
FMDARHKRGRGDIRA	WNT6	186	Q9Y6F9
GGKMRRERTRFVASK	NUP153	446	P49790
MLRRGYKASERRRHL	ZSWIM2	1	Q8NEG5
RRRHTMDKDSRGAAA	WNK1	56	Q9H4A3
KRGKRCRYRHPDMSE	ZC3H10	51	Q96K80
RHARDMRLKIGKGTG	VASH1	296	Q7L8A9
GKSFGDLVSRRKHMR	ZNF317	396	Q96PQ6
DARRSKCRIRLGGHM	ZNF692	21	Q9BU19
MMRRSLRAAGLGRHE	UBR5	991	O95071
HLGGKRAESARMRRA	PPP1R12B	6	O60237