Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetylcholine receptor regulator activity	SPDYE5 SPDYE2B SPDYE6 SPDYE2	1.90e-07	27	38	4	GO:0030548
GeneOntologyMolecularFunction	neurotransmitter receptor regulator activity	SPDYE5 SPDYE2B SPDYE6 SPDYE2	2.21e-07	28	38	4	GO:0099602
GeneOntologyMolecularFunction	N6-methyladenosine-containing RNA reader activity	YTHDF1 YTHDF3	3.65e-04	15	38	2	GO:1990247
GeneOntologyMolecularFunction	protein-RNA adaptor activity	YTHDF1 YTHDF3	9.48e-04	24	38	2	GO:0140517
GeneOntologyMolecularFunction	ubiquitin conjugating enzyme activity	UBE2A UBE2B	2.25e-03	37	38	2	GO:0061631
GeneOntologyMolecularFunction	transcription coactivator activity	KMT2C ARID1B ZMIZ1 SFR1	2.56e-03	303	38	4	GO:0003713
GeneOntologyMolecularFunction	ubiquitin-like protein conjugating enzyme activity	UBE2A UBE2B	3.03e-03	43	38	2	GO:0061650
GeneOntologyBiologicalProcess	positive regulation of cyclin-dependent protein serine/threonine kinase activity	SPDYE5 SPDYE2B SPDYE6 SPDYE2	1.08e-07	25	37	4	GO:0045737
GeneOntologyBiologicalProcess	positive regulation of cyclin-dependent protein kinase activity	SPDYE5 SPDYE2B SPDYE6 SPDYE2	1.74e-07	28	37	4	GO:1904031
GeneOntologyBiologicalProcess	regulation of cyclin-dependent protein serine/threonine kinase activity	SPDYE5 SPDYE2B SPDYE6 SPDYE2	2.59e-05	96	37	4	GO:0000079
GeneOntologyBiologicalProcess	regulation of cyclin-dependent protein kinase activity	SPDYE5 SPDYE2B SPDYE6 SPDYE2	3.04e-05	100	37	4	GO:1904029
GeneOntologyBiologicalProcess	regulation of cell cycle	ARID1B UBE2B SPDYE5 RUNX3 EP400 SPDYE2B ARID2 SPDYE6 PKP4 SPDYE2	5.18e-05	1256	37	10	GO:0051726
GeneOntologyBiologicalProcess	positive regulation of cell cycle	UBE2B SPDYE5 SPDYE2B SPDYE6 PKP4 SPDYE2	7.88e-05	407	37	6	GO:0045787
GeneOntologyBiologicalProcess	positive regulation of myoblast differentiation	ZFHX3 ARID1B ARID2	1.24e-04	54	37	3	GO:0045663
GeneOntologyBiologicalProcess	positive regulation of T cell differentiation	ARID1B ZMIZ1 RUNX3 ARID2	1.26e-04	144	37	4	GO:0045582
GeneOntologyBiologicalProcess	positive regulation of lymphocyte differentiation	ARID1B ZMIZ1 RUNX3 ARID2	1.98e-04	162	37	4	GO:0045621
GeneOntologyBiologicalProcess	positive regulation of protein serine/threonine kinase activity	SPDYE5 SPDYE2B SPDYE6 SPDYE2	3.85e-04	193	37	4	GO:0071902
GeneOntologyBiologicalProcess	positive regulation of DNA recombination	UBE2B EP400 ARID2	3.97e-04	80	37	3	GO:0045911
GeneOntologyBiologicalProcess	cytoplasm organization	TFCP2L1 ZMIZ1	4.70e-04	18	37	2	GO:0007028
GeneOntologyBiologicalProcess	regulation of myoblast differentiation	ZFHX3 ARID1B ARID2	5.98e-04	92	37	3	GO:0045661
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	HOXB1 KMT2C ZFHX3 TFCP2L1 ZNF600 ZMIZ1 SUPT5H ARID2 NR1D2	6.20e-04	1390	37	9	GO:0045944
GeneOntologyBiologicalProcess	positive regulation of double-strand break repair	ARID1B EP400 ARID2	6.57e-04	95	37	3	GO:2000781
GeneOntologyBiologicalProcess	regulation of T cell differentiation	ARID1B ZMIZ1 RUNX3 ARID2	6.98e-04	226	37	4	GO:0045580
GeneOntologyBiologicalProcess	positive regulation of leukocyte differentiation	ARID1B ZMIZ1 RUNX3 ARID2	9.01e-04	242	37	4	GO:1902107
GeneOntologyBiologicalProcess	positive regulation of hemopoiesis	ARID1B ZMIZ1 RUNX3 ARID2	9.01e-04	242	37	4	GO:1903708
GeneOntologyBiologicalProcess	chromatin organization	KMT2C ARID1B UBE2A UBE2B EP400 SUPT5H ARID2	9.37e-04	896	37	7	GO:0006325
GeneOntologyBiologicalProcess	DNA repair	ARID1B UBE2A UBE2B SFR1 EP400 ARID2	9.52e-04	648	37	6	GO:0006281
GeneOntologyBiologicalProcess	chordate embryonic development	HOXB1 HOXB8 UBE2A UBE2B ZMIZ1 CUBN NECAB1	1.00e-03	906	37	7	GO:0043009
GeneOntologyBiologicalProcess	regulation of mRNA metabolic process	YTHDF1 RBM5 TUT4 YTHDF3 NOVA1	1.11e-03	443	37	5	GO:1903311
GeneOntologyBiologicalProcess	embryo development ending in birth or egg hatching	HOXB1 HOXB8 UBE2A UBE2B ZMIZ1 CUBN NECAB1	1.16e-03	929	37	7	GO:0009792
GeneOntologyBiologicalProcess	regulation of nucleotide-excision repair	ARID1B ARID2	1.23e-03	29	37	2	GO:2000819
GeneOntologyBiologicalProcess	positive regulation of translational initiation	YTHDF1 YTHDF3	1.23e-03	29	37	2	GO:0045948
GeneOntologyBiologicalProcess	regulation of lymphocyte differentiation	ARID1B ZMIZ1 RUNX3 ARID2	1.28e-03	266	37	4	GO:0045619
GeneOntologyBiologicalProcess	positive regulation of T cell activation	ARID1B ZMIZ1 RUNX3 ARID2	1.75e-03	290	37	4	GO:0050870
GeneOntologyBiologicalProcess	protein-DNA complex organization	KMT2C ARID1B UBE2A UBE2B EP400 SUPT5H ARID2	1.76e-03	999	37	7	GO:0071824
GeneOntologyBiologicalProcess	myoblast differentiation	ZFHX3 ARID1B ARID2	1.85e-03	136	37	3	GO:0045445
GeneOntologyBiologicalProcess	chromatin remodeling	KMT2C ARID1B UBE2A EP400 SUPT5H ARID2	1.89e-03	741	37	6	GO:0006338
GeneOntologyBiologicalProcess	stress granule assembly	YTHDF1 YTHDF3	1.90e-03	36	37	2	GO:0034063
GeneOntologyBiologicalProcess	protein K11-linked ubiquitination	UBE2A UBE2B	2.00e-03	37	37	2	GO:0070979
GeneOntologyBiologicalProcess	postreplication repair	UBE2A UBE2B	2.11e-03	38	37	2	GO:0006301
GeneOntologyBiologicalProcess	positive regulation of DNA repair	ARID1B EP400 ARID2	2.13e-03	143	37	3	GO:0045739
GeneOntologyBiologicalProcess	organism emergence from protective structure	UBE2A NECAB1	2.23e-03	39	37	2	GO:0071684
GeneOntologyBiologicalProcess	hatching	UBE2A NECAB1	2.23e-03	39	37	2	GO:0035188
GeneOntologyBiologicalProcess	blastocyst hatching	UBE2A NECAB1	2.23e-03	39	37	2	GO:0001835
GeneOntologyBiologicalProcess	regulation of double-strand break repair	ARID1B EP400 ARID2	2.26e-03	146	37	3	GO:2000779
GeneOntologyBiologicalProcess	positive regulation of leukocyte cell-cell adhesion	ARID1B ZMIZ1 RUNX3 ARID2	2.42e-03	317	37	4	GO:1903039
GeneOntologyBiologicalProcess	regulation of DNA recombination	UBE2B EP400 ARID2	2.44e-03	150	37	3	GO:0000018
GeneOntologyBiologicalProcess	regulation of G0 to G1 transition	ARID1B ARID2	2.58e-03	42	37	2	GO:0070316
GeneOntologyBiologicalProcess	double-strand break repair	ARID1B SFR1 EP400 ARID2	2.62e-03	324	37	4	GO:0006302
GeneOntologyBiologicalProcess	regulation of hemopoiesis	HOXB8 ARID1B ZMIZ1 RUNX3 ARID2	2.63e-03	540	37	5	GO:1903706
GeneOntologyCellularComponent	chromatin	HOXB1 ZFHX3 HOXB8 TFCP2L1 ARID1B UBE2A UBE2B ZMIZ1 RUNX3 SFR1 EP400 ARID2 NR1D2	7.60e-07	1480	37	13	GO:0000785
GeneOntologyCellularComponent	HULC complex	UBE2A UBE2B	1.82e-05	4	37	2	GO:0033503
GeneOntologyCellularComponent	ubiquitin conjugating enzyme complex	UBE2A UBE2B	1.09e-04	9	37	2	GO:0031371
GeneOntologyCellularComponent	SWI/SNF superfamily-type complex	ARID1B EP400 ARID2	6.51e-04	96	37	3	GO:0070603
GeneOntologyCellularComponent	XY body	UBE2A UBE2B	7.53e-04	23	37	2	GO:0001741
GeneOntologyCellularComponent	SWI/SNF complex	ARID1B ARID2	1.29e-03	30	37	2	GO:0016514
GeneOntologyCellularComponent	ATPase complex	ARID1B EP400 ARID2	1.53e-03	129	37	3	GO:1904949
GeneOntologyCellularComponent	nuclear protein-containing complex	RBM5 KMT2C ARID1B RUNX3 SFR1 EP400 SUPT5H ARID2	2.41e-03	1377	37	8	GO:0140513
GeneOntologyCellularComponent	sex chromosome	UBE2A UBE2B	2.75e-03	44	37	2	GO:0000803
MousePheno	inlet ventricular septal defect	ARID2 NR1D2	4.43e-05	5	30	2	MP:0010419
Domain	Speedy	SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE2	1.21e-11	11	38	5	IPR020984
Domain	Spy1	SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE2	1.21e-11	11	38	5	PF11357
Domain	YTH	YTHDF1 YTHDF3	4.02e-05	5	38	2	PS50882
Domain	YTH_domain	YTHDF1 YTHDF3	4.02e-05	5	38	2	IPR007275
Domain	YTH	YTHDF1 YTHDF3	4.02e-05	5	38	2	PF04146
Domain	-	ARID1B ARID2	4.16e-04	15	38	2	1.10.150.60
Domain	ARID	ARID1B ARID2	4.16e-04	15	38	2	PF01388
Domain	BRIGHT	ARID1B ARID2	4.16e-04	15	38	2	SM00501
Domain	ARID_dom	ARID1B ARID2	4.16e-04	15	38	2	IPR001606
Domain	ARID	ARID1B ARID2	4.16e-04	15	38	2	PS51011
Domain	ANTENNAPEDIA	HOXB1 HOXB8	1.08e-03	24	38	2	PS00032
Domain	UBQ-conjugating_AS	UBE2A UBE2B	1.17e-03	25	38	2	IPR023313
Domain	UQ_con	UBE2A UBE2B	2.85e-03	39	38	2	PF00179
Domain	UBIQUITIN_CONJUGAT_1	UBE2A UBE2B	2.99e-03	40	38	2	PS00183
Domain	UBIQUITIN_CONJUGAT_2	UBE2A UBE2B	3.14e-03	41	38	2	PS50127
Domain	UBQ-conjugat_E2	UBE2A UBE2B	3.14e-03	41	38	2	IPR000608
Domain	Homeodomain-like	HOXB1 ZFHX3 HOXB8 EP400	4.50e-03	332	38	4	IPR009057
Domain	-	UBE2A UBE2B	4.83e-03	51	38	2	3.10.110.10
Domain	UBQ-conjugating_enzyme/RWD	UBE2A UBE2B	5.20e-03	53	38	2	IPR016135
Domain	Homeobox_CS	HOXB1 ZFHX3 HOXB8	6.35e-03	186	38	3	IPR017970
Domain	Homeobox	HOXB1 ZFHX3 HOXB8	1.19e-02	234	38	3	PF00046
Domain	HOMEOBOX_1	HOXB1 ZFHX3 HOXB8	1.21e-02	236	38	3	PS00027
Domain	HOX	HOXB1 ZFHX3 HOXB8	1.23e-02	237	38	3	SM00389
Domain	Homeobox_dom	HOXB1 ZFHX3 HOXB8	1.26e-02	239	38	3	IPR001356
Domain	HOMEOBOX_2	HOXB1 ZFHX3 HOXB8	1.26e-02	239	38	3	PS50071
Pathway	REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION	ZFHX3 RUNX3	4.51e-05	6	25	2	MM15534
Pathway	REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION	ZFHX3 RUNX3	6.31e-05	7	25	2	M27807
Pubmed	Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.	SPDYE5 SPDYE2B SPDYE6 SPDYE2	1.69e-10	9	39	4	36272447
Pubmed	Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.	SPDYE5 SPDYE2B SPDYE6 SPDYE2	9.58e-10	13	39	4	15611625
Pubmed	Characterization of a new family of cyclin-dependent kinase activators.	SPDYE5 SPDYE2B SPDYE6 SPDYE2	3.18e-09	17	39	4	15574121
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	YTHDF1 LENG8 KMT2C ARID1B ZMIZ1 TFG RBM27 YTHDF3	3.60e-08	457	39	8	32344865
Pubmed	Interaction network of human early embryonic transcription factors.	KMT2C ZFHX3 ARID1B ZMIZ1 EP400 ARID2 YTHDF3	1.17e-07	351	39	7	38297188
Pubmed	Knockout mouse model and gametogenic failure.	GJA4 UBE2A UBE2B	1.56e-07	10	39	3	9922113
Pubmed	Cytoplasmic m6A reader YTHDF3 promotes mRNA translation.	YTHDF1 YTHDF3	1.23e-06	2	39	2	28106076
Pubmed	The NMR structure of the class I human ubiquitin-conjugating enzyme 2b.	UBE2A UBE2B	1.23e-06	2	39	2	11885984
Pubmed	Deletion of YTHDF1 (not YTHDF3) reduced brain and gut damage after traumatic brain injury.	YTHDF1 YTHDF3	1.23e-06	2	39	2	39081030
Pubmed	RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance.	UBE2A UBE2B	1.23e-06	2	39	2	28806395
Pubmed	The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice.	UBE2A UBE2B	1.23e-06	2	39	2	15169909
Pubmed	Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase.	UBE2A UBE2B	1.23e-06	2	39	2	12556476
Pubmed	Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction.	ZFHX3 RUNX3	1.23e-06	2	39	2	20599712
Pubmed	Acquisition of Hox codes during gastrulation and axial elongation in the mouse embryo.	HOXB1 HOXB8	1.23e-06	2	39	2	12835396
Pubmed	Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6.	UBE2A UBE2B	1.23e-06	2	39	2	1717990
Pubmed	Alternative Splicing of RAD6B and Not RAD6A is Selectively Increased in Melanoma: Identification and Functional Characterization.	UBE2A UBE2B	1.23e-06	2	39	2	31683936
Pubmed	Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31.	UBE2A UBE2B	1.23e-06	2	39	2	1559696
Pubmed	m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs.	YTHDF1 ARID1B YTHDF3	1.25e-06	19	39	3	36039295
Pubmed	Human transcription factor protein interaction networks.	YTHDF1 LENG8 KMT2C ZFHX3 ARID1B ZMIZ1 EP400 RBM27 ARID2 YTHDF3	2.84e-06	1429	39	10	35140242
Pubmed	YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA.	YTHDF1 YTHDF3	3.67e-06	3	39	2	28106072
Pubmed	YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation.	YTHDF1 YTHDF3	3.67e-06	3	39	2	35508130
Pubmed	Differential roles of BAF and PBAF subunits, Arid1b and Arid2, in MLL-AF9 leukemogenesis.	ARID1B ARID2	3.67e-06	3	39	2	35022500
Pubmed	Comprehensive Analysis of YTH Domain Family in Lung Adenocarcinoma: Expression Profile, Association with Prognostic Value, and Immune Infiltration.	YTHDF1 YTHDF3	3.67e-06	3	39	2	34497675
Pubmed	Evolution of the Cdk-activator Speedy/RINGO in vertebrates.	SPDYE6 SPDYE2	3.67e-06	3	39	2	22763696
Pubmed	Enhanced genomic instability and defective postreplication repair in RAD18 knockout mouse embryonic stem cells.	UBE2A UBE2B	3.67e-06	3	39	2	12509447
Pubmed	RNF168 forms a functional complex with RAD6 during the DNA damage response.	UBE2A UBE2B	3.67e-06	3	39	2	23525009
Pubmed	Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer.	ARID1B ARID2	3.67e-06	3	39	2	24382590
Pubmed	UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4.	UBE2A UBE2B	3.67e-06	3	39	2	38182926
Pubmed	The human RAD18 gene product interacts with HHR6A and HHR6B.	UBE2A UBE2B	3.67e-06	3	39	2	10908344
Pubmed	A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA.	YTHDF1 YTHDF3	3.67e-06	3	39	2	32492408
Pubmed	Genome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF Complexes.	ARID1B ARID2	3.67e-06	3	39	2	26716708
Pubmed	m6A-binding YTHDF proteins promote stress granule formation.	YTHDF1 YTHDF3	3.67e-06	3	39	2	32451507
Pubmed	Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens.	UBE2A UBE2B	3.67e-06	3	39	2	10884424
Pubmed	m6A enhances the phase separation potential of mRNA.	YTHDF1 YTHDF3	3.67e-06	3	39	2	31292544
Pubmed	N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.	YTHDF1 YTHDF3	3.67e-06	3	39	2	27371828
Pubmed	ARID1A, ARID1B, and ARID2 Mutations Serve as Potential Biomarkers for Immune Checkpoint Blockade in Patients With Non-Small Cell Lung Cancer.	ARID1B ARID2	3.67e-06	3	39	2	34512623
Pubmed	Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation.	ARID1B TFG ARID2	4.19e-06	28	39	3	30037996
Pubmed	Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation.	UBE2A UBE2B	7.34e-06	4	39	2	11929833
Pubmed	RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1.	UBE2A UBE2B	7.34e-06	4	39	2	25384975
Pubmed	RAD6 regulates the dosage of p53 by a combination of transcriptional and posttranscriptional mechanisms.	UBE2A UBE2B	7.34e-06	4	39	2	22083959
Pubmed	N6-methyladenosine-dependent regulation of messenger RNA stability.	YTHDF1 YTHDF3	7.34e-06	4	39	2	24284625
Pubmed	Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability.	UBE2A UBE2B	7.34e-06	4	39	2	36162503
Pubmed	A conserved RAD6-MDM2 ubiquitin ligase machinery targets histone chaperone ASF1A in tumorigenesis.	UBE2A UBE2B	7.34e-06	4	39	2	26336826
Pubmed	ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins.	UBE2A UBE2B	7.34e-06	4	39	2	12776193
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	LENG8 ARID1B EP400 RBM27 SUPT5H ARID2	9.08e-06	440	39	6	34244565
Pubmed	A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.	HOXB1 HOXB8 CUBN NR1D2	9.45e-06	118	39	4	16971476
Pubmed	Context-dependent functional compensation between Ythdf m6A reader proteins.	YTHDF1 YTHDF3	1.22e-05	5	39	2	32943573
Pubmed	Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination.	UBE2A UBE2B	1.22e-05	5	39	2	15359278
Pubmed	Recent advances in understanding chromatin remodeling by Swi/Snf complexes.	ARID1B ARID2	1.22e-05	5	39	2	12672490
Pubmed	Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks.	UBE2A UBE2B	1.22e-05	5	39	2	18363965
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	YTHDF1 RBM5 ARID1B TUT4 EP400 TFG YTHDF3	1.54e-05	733	39	7	34672954
Pubmed	NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis.	UBE2A UBE2B	1.83e-05	6	39	2	21884979
Pubmed	Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination.	UBE2A UBE2B	1.83e-05	6	39	2	27678051
Pubmed	Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase.	UBE2A UBE2B	1.83e-05	6	39	2	15383616
Pubmed	Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks.	UBE2A UBE2B	1.83e-05	6	39	2	21858012
Pubmed	Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems.	UBE2A UBE2B	1.83e-05	6	39	2	17462990
Pubmed	Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response.	UBE2A UBE2B	2.56e-05	7	39	2	11714696
Pubmed	Developmental regulation of the Hox genes during axial morphogenesis in the mouse.	HOXB1 HOXB8	2.56e-05	7	39	2	15944185
Pubmed	Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.	UBE2A UBE2B	2.56e-05	7	39	2	21816346
Pubmed	Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis.	UBE2A UBE2B	2.56e-05	7	39	2	15657431
Pubmed	Transient pluripotent cell populations during primitive ectoderm formation: correlation of in vivo and in vitro pluripotent cell development.	TFCP2L1 RBM27	2.56e-05	7	39	2	11839785
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	YTHDF1 RBM5 TUT4 RBM27 SUPT5H YTHDF3 NOVA1	2.84e-05	807	39	7	22681889
Pubmed	Nucleosomal H2B ubiquitylation with purified factors.	UBE2A UBE2B	3.42e-05	8	39	2	21443952
Pubmed	Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system.	ZFHX3 UBE2B NOVA1	4.27e-05	60	39	3	29055695
Pubmed	Coffin-Siris Syndrome	ARID1B ARID2	4.39e-05	9	39	2	23556151
Pubmed	A yeast artificial chromosome containing the mouse homeobox cluster Hox-2.	HOXB1 HOXB8	4.39e-05	9	39	2	1972280
Pubmed	A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.	KMT2C ARID1B ARID2	4.49e-05	61	39	3	20305087
Pubmed	Nomenclature of the ARID family of DNA-binding proteins.	ARID1B ARID2	5.48e-05	10	39	2	15922553
Pubmed	ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF.	ARID1B ARID2	5.48e-05	10	39	2	23129809
Pubmed	Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain.	HOXB1 HOXB8	5.48e-05	10	39	2	2571936
Pubmed	Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A.	UBE2A UBE2B	5.48e-05	10	39	2	37633270
Pubmed	A large targeted deletion of Hoxb1-Hoxb9 produces a series of single-segment anterior homeotic transformations.	HOXB1 HOXB8	6.70e-05	11	39	2	10885747
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	ARID1B ZMIZ1 RUNX3 EP400 RBM27	7.81e-05	396	39	5	26687479
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	KMT2C ARID1B EP400 SUPT5H ARID2	8.00e-05	398	39	5	35016035
Pubmed	Expression of class I homeobox genes in fetal and adult murine skin.	HOXB1 HOXB8	8.03e-05	12	39	2	8105001
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	YTHDF1 LENG8 ARID1B EP400 RBM27 ARID2 YTHDF3	8.17e-05	954	39	7	36373674
Pubmed	Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development.	HOXB1 HOXB8	9.48e-05	13	39	2	24525295
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	KMT2C ZFHX3 ARID1B ARID2	1.08e-04	220	39	4	35785414
Pubmed	Quantitative trait loci for periosteal circumference (PC): identification of single loci and epistatic effects in F2 MRL/SJL mice.	HOXB1 HOXB8	1.11e-04	14	39	2	12753872
Pubmed	Cdx2 is essential for axial elongation in mouse development.	HOXB1 HOXB8	1.27e-04	15	39	2	15136723
Pubmed	A distinct Hox code for the branchial region of the vertebrate head.	HOXB1 HOXB8	1.27e-04	15	39	2	1682814
Pubmed	The DNA sequence of human chromosome 7.	SPDYE21 KMT2C SPDYE5 SPDYE2B SPDYE6	1.29e-04	441	39	5	12853948
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	YTHDF1 LENG8 TUT4 YTHDF3 PKP4	1.61e-04	462	39	5	31138677
Pubmed	New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.	UBE2A UBE2B	1.65e-04	17	39	2	26489670
Pubmed	The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.	ARID1B ARID2	1.65e-04	17	39	2	11078522
Pubmed	Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor.	UBE2A UBE2B	1.65e-04	17	39	2	33650289
Pubmed	Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method.	UBE2A UBE2B	1.65e-04	17	39	2	36563856
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	ARID1B EP400 TFG ARID2 YTHDF3	1.77e-04	472	39	5	38943005
Pubmed	RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells.	UBE2A UBE2B	1.85e-04	18	39	2	19410543
Pubmed	Expression of homeobox genes, including an insulin promoting factor, in the murine yolk sac at the time of hematopoietic initiation.	HOXB1 HOXB8	1.85e-04	18	39	2	9291463
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	RBM5 LENG8 KMT2C ARID1B EP400 RBM27 ARID2	2.00e-04	1103	39	7	34189442
Pubmed	Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.	ARID1B ARID2	2.07e-04	19	39	2	12110891
Pubmed	Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity.	UBE2A UBE2B	2.07e-04	19	39	2	27425610
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ARID1B LRFN2 ZMIZ1	2.13e-04	103	39	3	10574462
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	HOXB1 ZFHX3 HOXB8 NR1D2	2.13e-04	263	39	4	20932939
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	RBM5 LENG8 KMT2C ZFHX3 EP400 RBM27 ARID2 PKP4	2.16e-04	1497	39	8	31527615
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	LENG8 ARID1B EP400 RBM27	2.29e-04	268	39	4	33640491
Pubmed	Evolutionarily conserved requirement of Cdx for post-occipital tissue emergence.	HOXB1 HOXB8	2.54e-04	21	39	2	22675207
Pubmed	Organization of human class I homeobox genes.	HOXB1 HOXB8	2.79e-04	22	39	2	2576652
Pubmed	Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs.	HOXB1 HOXB8	2.79e-04	22	39	2	26283362
Interaction	CRX interactions	KMT2C ZFHX3 ARID1B ZMIZ1 EP400 TFG ARID2	3.47e-07	254	37	7	int:CRX
Interaction	NUP35 interactions	YTHDF1 LENG8 KMT2C ARID1B ZMIZ1 TFG RBM27 YTHDF3	8.13e-07	424	37	8	int:NUP35
Interaction	SP7 interactions	LENG8 KMT2C ARID1B ZMIZ1 EP400 RBM27 ARID2	1.16e-06	304	37	7	int:SP7
Interaction	KLF5 interactions	LENG8 KMT2C ARID1B EP400 ARID2 YTHDF3	1.38e-06	195	37	6	int:KLF5
Interaction	FEV interactions	LENG8 KMT2C ZFHX3 ARID1B EP400 ARID2	1.74e-06	203	37	6	int:FEV
Interaction	EGR2 interactions	KMT2C ZFHX3 ARID1B EP400 ARID2	1.45e-05	171	37	5	int:EGR2
Interaction	SNRNP40 interactions	RBM5 LENG8 ZFHX3 ARID1B SFR1 EP400 SUPT5H ARID2	1.64e-05	637	37	8	int:SNRNP40
Interaction	LHX2 interactions	KMT2C ZFHX3 ARID1B EP400 ARID2	2.01e-05	183	37	5	int:LHX2
Interaction	HNF1B interactions	KMT2C ZFHX3 ARID1B EP400 ARID2	2.41e-05	190	37	5	int:HNF1B
Interaction	SOX9 interactions	KMT2C ARID1B EP400 ARID2	2.95e-05	97	37	4	int:SOX9
Interaction	PAX6 interactions	HOXB1 KMT2C ZFHX3 ARID1B EP400 ARID2	4.97e-05	366	37	6	int:PAX6
Interaction	TBR1 interactions	KMT2C ZFHX3 ARID1B ZMIZ1	5.37e-05	113	37	4	int:TBR1
Interaction	NFIX interactions	KMT2C ZFHX3 ARID1B EP400 ARID2	5.64e-05	227	37	5	int:NFIX
Interaction	ETS1 interactions	ARID1B ZMIZ1 EP400 ARID2	7.01e-05	121	37	4	int:ETS1
Interaction	POU5F1 interactions	ZFHX3 TFCP2L1 ARID1B TUT4 CUBN EP400 RBM27	8.00e-05	584	37	7	int:POU5F1
Interaction	ASF1A interactions	LENG8 TFCP2L1 ARID1B EP400 ARID2	8.73e-05	249	37	5	int:ASF1A
Interaction	ZNF34 interactions	YTHDF1 LENG8 TFG	9.90e-05	49	37	3	int:ZNF34
Interaction	CELF1 interactions	YTHDF1 RBM5 TUT4 RBM27 YTHDF3	1.73e-04	288	37	5	int:CELF1
Interaction	GAS5 interactions	RUNX3 YTHDF3	1.79e-04	11	37	2	int:GAS5
Interaction	BICRA interactions	ARID1B SUPT5H ARID2	2.52e-04	67	37	3	int:BICRA
Interaction	GCM1 interactions	YTHDF1 KMT2C ARID1B	2.63e-04	68	37	3	int:GCM1
Interaction	SMG7 interactions	YTHDF1 RBM5 LENG8 ARID1B YTHDF3	2.77e-04	319	37	5	int:SMG7
Interaction	TEAD1 interactions	KMT2C ZFHX3 ARID1B ARID2	2.96e-04	176	37	4	int:TEAD1
Interaction	B9D2 interactions	YTHDF1 ARID1B YTHDF3	3.24e-04	73	37	3	int:B9D2
Interaction	ALG13 interactions	YTHDF1 LENG8 ARID1B YTHDF3	3.44e-04	183	37	4	int:ALG13
Interaction	AR interactions	LENG8 KMT2C ZFHX3 ARID1B ZMIZ1 EP400 RBM27 ARID2	3.61e-04	992	37	8	int:AR
Interaction	CPSF7 interactions	YTHDF1 LENG8 TUT4 SUPT5H YTHDF3	3.61e-04	338	37	5	int:CPSF7
Interaction	SOX7 interactions	KMT2C ARID1B ARID2	4.57e-04	82	37	3	int:SOX7
Interaction	MEN1 interactions	YTHDF1 RBM5 LENG8 KMT2C ARID1B EP400 ARID2 YTHDF3	4.62e-04	1029	37	8	int:MEN1
Interaction	GATA2 interactions	KMT2C ZFHX3 ARID1B ARID2	4.72e-04	199	37	4	int:GATA2
Interaction	WAC interactions	UBE2A UBE2B SUPT5H	4.73e-04	83	37	3	int:WAC
Interaction	SMARCB1 interactions	LENG8 KMT2C TFCP2L1 ARID1B ARID2	5.07e-04	364	37	5	int:SMARCB1
Interaction	IRF4 interactions	KMT2C ARID1B ARID2	5.07e-04	85	37	3	int:IRF4
Interaction	GSC interactions	KMT2C ZFHX3 ARID1B	5.43e-04	87	37	3	int:GSC
Interaction	TEX13B interactions	ARID1B ARID2	6.10e-04	20	37	2	int:TEX13B
Interaction	DMRTB1 interactions	YTHDF1 LENG8 YTHDF3	6.81e-04	94	37	3	int:DMRTB1
Interaction	SOX17 interactions	KMT2C ARID1B ARID2	7.02e-04	95	37	3	int:SOX17
Interaction	MEX3B interactions	YTHDF1 TUT4 RUNX3 YTHDF3	7.12e-04	222	37	4	int:MEX3B
Interaction	CCNH interactions	HOXB1 TFG SUPT5H	7.68e-04	98	37	3	int:CCNH
Interaction	KLF3 interactions	ZFHX3 ARID1B EP400 ARID2	7.86e-04	228	37	4	int:KLF3
Interaction	HDLBP interactions	YTHDF1 RBM5 LENG8 UBE2A EP400 RBM27 YTHDF3	8.15e-04	855	37	7	int:HDLBP
Interaction	INTS11 interactions	LENG8 TFG SUPT5H	8.39e-04	101	37	3	int:INTS11
Interaction	UNK interactions	YTHDF1 UBE2A UBE2B TFG YTHDF3	8.48e-04	408	37	5	int:UNK
Interaction	SUPT5H interactions	LENG8 ARID1B ZFYVE9 EP400 SUPT5H	8.48e-04	408	37	5	int:SUPT5H
Interaction	SOX2 interactions	YTHDF1 RBM5 KMT2C ZFHX3 ARID1B EP400 SUPT5H ARID2 PKP4	8.64e-04	1422	37	9	int:SOX2
Interaction	LHX1 interactions	KMT2C ARID1B ARID2	8.88e-04	103	37	3	int:LHX1
Interaction	SIRT6 interactions	LENG8 ARID1B EP400 RBM27 SUPT5H ARID2	9.12e-04	628	37	6	int:SIRT6
Interaction	KLF16 interactions	YTHDF1 LENG8 EP400 ARID2 YTHDF3	1.02e-03	425	37	5	int:KLF16
Interaction	SLF1 interactions	UBE2A UBE2B	1.04e-03	26	37	2	int:SLF1
Cytoband	17q21.3	HOXB1 HOXB8	8.37e-05	16	39	2	17q21.3
Cytoband	7q22.1	SPDYE2B SPDYE6 SPDYE2	1.24e-04	113	39	3	7q22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	SPDYE2B SPDYE6 SPDYE2	8.62e-04	219	39	3	chr7q22
Cytoband	1p32.3	TUT4 ZFYVE9	1.25e-03	61	39	2	1p32.3
GeneFamily	Speedy/RINGO cell cycle regulator family	SPDYE5 SPDYE2B SPDYE6 SPDYE2	1.65e-09	12	26	4	756
GeneFamily	AT-rich interaction domain containing	ARID1B ARID2	2.06e-04	15	26	2	418
GeneFamily	Ubiquitin conjugating enzymes E2	UBE2A UBE2B	1.58e-03	41	26	2	102
GeneFamily	HOXL subclass homeoboxes	HOXB1 HOXB8	2.52e-03	52	26	2	518
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#1_top-relative-expression-ranked_1000	RBM5 ZFHX3 TUT4 ZMIZ1	2.61e-05	99	37	4	gudmap_developingGonad_e14.5_ epididymis_1000_k1
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000	KMT2C ZNF600 UBE2A ZFYVE9 CUBN RBM27 NR1D2 NOVA1	6.82e-05	820	37	8	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	ARID1B TUT4 UBE2B ARID2	2.35e-05	192	39	4	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	ARID1B TUT4 UBE2B ARID2	2.40e-05	193	39	4	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	KMT2C ARID1B TUT4 RUNX3	2.60e-05	197	39	4	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	KMT2C ARID1B TUT4 RUNX3	2.65e-05	198	39	4	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KMT2C ARID1B TUT4 RUNX3	2.65e-05	198	39	4	28ef3fc4c17dcb765537b75917f7db78baa522db
Disease	lung non-small cell carcinoma (is_implicated_in)	KMT2C ZFHX3 ARID1B RUNX3	2.47e-05	139	36	4	DOID:3908 (is_implicated_in)
Disease	congenital heart disease (implicated_via_orthology)	KMT2C UBE2A UBE2B	8.27e-05	69	36	3	DOID:1682 (implicated_via_orthology)
Disease	mucocutaneous lymph node syndrome	ZFHX3 TECRL CUBN	1.10e-04	76	36	3	EFO_0004246
Disease	Coffin-Siris syndrome	ARID1B ARID2	1.12e-04	13	36	2	C0265338
Disease	syndromic intellectual disability (implicated_via_orthology)	UBE2A UBE2B	1.72e-04	16	36	2	DOID:0050888 (implicated_via_orthology)
Disease	disease of metabolism (implicated_via_orthology)	YTHDF1 YTHDF3	3.00e-04	21	36	2	DOID:0014667 (implicated_via_orthology)
Disease	red blood cell density measurement	TFCP2L1 ARID1B EP400 PCDHGA5 ARID2 PKP4	6.27e-04	880	36	6	EFO_0007978
Disease	autism spectrum disorder (implicated_via_orthology)	ARID1B LRFN2 PKP4	8.45e-04	152	36	3	DOID:0060041 (implicated_via_orthology)
Disease	non-alcoholic fatty liver disease (implicated_via_orthology)	UBE2A UBE2B	8.88e-04	36	36	2	DOID:0080208 (implicated_via_orthology)
Disease	cognitive function measurement, self reported educational attainment	RBM5 ARID1B NR1D2 NOVA1	8.95e-04	355	36	4	EFO_0004784, EFO_0008354
Disease	Celiac Disease	ZMIZ1 RUNX3	1.51e-03	47	36	2	C0007570
Disease	Colorectal Carcinoma	KMT2C ZMIZ1 SLC11A2 CUBN TFG	1.54e-03	702	36	5	C0009402
Disease	lung adenocarcinoma (is_implicated_in)	KMT2C ZFHX3	1.64e-03	49	36	2	DOID:3910 (is_implicated_in)
Disease	sitting height ratio	ARID1B ZMIZ1	1.78e-03	51	36	2	EFO_0007118
Disease	psoriasis vulgaris	ZMIZ1 RUNX3	2.53e-03	61	36	2	EFO_1001494
Disease	Liver carcinoma	KMT2C ARID1B RUNX3 ARID2	3.28e-03	507	36	4	C2239176
Disease	Drugs used in diabetes use measurement	ZFHX3 LRFN2 ZMIZ1	3.69e-03	255	36	3	EFO_0009924
Disease	psoriasis, type 2 diabetes mellitus	ZMIZ1 RUNX3	3.80e-03	75	36	2	EFO_0000676, MONDO_0005148
Disease	ankylosing spondylitis	ZMIZ1 RUNX3	5.54e-03	91	36	2	EFO_0003898
Disease	Neurodevelopmental Disorders	KMT2C ARID1B	5.77e-03	93	36	2	C1535926
Disease	hepatocellular carcinoma (is_marker_for)	ZFHX3 RUNX3 ARID2	5.85e-03	301	36	3	DOID:684 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
TSNPNGPTPQYQTTA	PKP4	296	Q99569
QYDPSTGPPVQNAAS	EP400	571	Q96L91
QPNSSQPSPFSGSSQ	ARID2	1606	Q68CP9
SNPHSQPQQSSPYPG	ARID1B	616	Q8NFD5
PPPNSSEQYSSGAQS	RBM27	221	Q9P2N5
NDNPPNFPQASYSTS	PCDHGA5	446	Q9Y5G8
SHNQSNDPYSQPPLT	KMT2C	2086	Q8NEZ4
GSYGSATPQQPSAPQ	LENG8	121	Q96PV6
NINPAYSNPSLSQSP	SLC11A2	26	P49281
QSPQLYNQTSNPPGS	RBM5	411	P52756
YNQTSNPPGSPTEEA	RBM5	416	P52756
PSSLSTAPYQQNPCA	HOXB8	61	P17481
TVSSPRFPANYPNNQ	CUBN	1631	O60494
AFQQNSGYPAQQPPS	HOXB1	56	P14653
PPCPTYNGLSSSEQN	GJA4	276	P35212
PVANSNPTGSPYANT	NOVA1	261	P51513
PSSPNSSNSDTNGNP	NR1D2	41	Q14995
PQNQSGPFQANPSPY	RUNX3	316	Q13761
NTDQFSPYAAPSPQG	SUPT5H	886	O00267
QVNSAPSPSYNGSPN	TFCP2L1	266	Q9NZI6
STPQASANPSSPYTN	SFR1	26	Q86XK3
PQNEQSPQRSTSGYP	SPDYE2B	26	A6NHP3
SQTNQSNSYPPMSDP	YTHDF3	41	Q7Z739
ANSPSGSNQPTNPNR	ST20-AS1	31	Q8NBB2
YGQQPTSQAPAPAFS	TFG	291	Q92734
PQNEQSPQRSTSGYP	SPDYE21	26	A0A494C086
PQNEQSPQRSTSGYP	SPDYE2	26	Q495Y8
PQNEQSPQRSTSGYP	SPDYE5	26	A6NIY4
PQNEQSPQRSTSGYP	SPDYE6	26	P0CI01
PNPNSPANSQAAQLY	UBE2A	116	P49459
HTGNNACFPSPNYNP	TECRL	276	Q5HYJ1
YSPQPQPFPQNSSQS	TUT4	1426	Q5TAX3
SNNYGNNSPNSSLLP	ZNF600	136	Q6ZNG1
PNPNSPANSQAAQLY	UBE2B	116	P63146
SQSPNPNNPAEYCST	ZFYVE9	771	O95405
NSQFPTQPGQYPAPN	ZMIZ1	421	Q9ULJ6
SDSNSPGNVQPNSAP	YTHDF1	346	Q9BYJ9
MPSQAYSAPAPSANN	ZFHX3	2386	Q15911
YSQTNGAQPPPPSSA	LRFN2	576	Q9ULH4
NSFSPNSPQFNVSGP	NECAB1	191	Q8N987