Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF717 ZNF676 ZNF117 ZNF33B ZNF391 ZNF41 ZNF257 ZNF728 ZNF254 ZNF724 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF83 ZNF91 ZNF107 ZNF714 ZNF726 ZNF595 ZNF124 ZNF44 ZNF3	5.20e-10	1412	79	24	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF717 ZNF676 ZNF117 ZNF33B ZNF391 ZNF41 ZNF257 ZNF728 ZNF254 ZNF724 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF83 ZNF91 ZNF107 ZNF714 ZNF726 ZNF595 ZNF124 ZNF44 ZNF3	1.01e-09	1459	79	24	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF717 ZNF676 ZNF117 ZNF33B ZNF41 ZNF257 ZNF728 ZNF254 ZNF724 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF83 ZNF91 ZNF107 ZNF714 ZNF726 ZNF595 ZNF3	9.38e-09	1244	79	21	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF717 ZNF676 ZNF117 ZNF33B ZNF41 ZNF257 ZNF728 ZNF254 ZNF724 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF83 ZNF91 ZNF107 ZNF714 ZNF726 ZNF595 ZNF3	1.37e-08	1271	79	21	GO:0000987
GeneOntologyMolecularFunction	pore-forming activity	MMD MMD2	6.81e-04	10	79	2	GO:0140911
GeneOntologyBiologicalProcess	transposable element silencing	ZNF208 ZNF91 ZNF107 ZNF726	3.02e-05	46	80	4	GO:0010526
GeneOntologyBiologicalProcess	retrotransposition	ZNF208 ZNF91 ZNF107 ZNF726	3.59e-05	48	80	4	GO:0032197
GeneOntologyBiologicalProcess	transposition	ZNF208 ZNF91 ZNF107 ZNF726	4.22e-05	50	80	4	GO:0032196
GeneOntologyBiologicalProcess	negative regulation of gene expression via chromosomal CpG island methylation	ZNF254 ZNF726 ZNF595	9.41e-05	23	80	3	GO:0044027
MousePheno	decreased eosinophil cell number	ABCC5 ZNF208 ZNF85 ZNF91 ZNF107	1.59e-05	84	53	5	MP:0005012
Domain	KRAB	ZNF676 ZNF33B ZNF41 ZNF257 ZNF728 ZNF254 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF91 ZNF738 ZNF714 ZNF726 ZNF595 ZNF124 ZNF44 ZNF3	2.06e-16	358	76	19	PS50805
Domain	KRAB	ZNF676 ZNF33B ZNF41 ZNF257 ZNF728 ZNF254 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF91 ZNF738 ZNF714 ZNF726 ZNF595 ZNF124 ZNF44 ZNF3	3.59e-16	369	76	19	SM00349
Domain	KRAB	ZNF676 ZNF33B ZNF41 ZNF257 ZNF728 ZNF254 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF91 ZNF738 ZNF714 ZNF726 ZNF595 ZNF124 ZNF44 ZNF3	3.78e-16	370	76	19	IPR001909
Domain	zf-C2H2	ZNF676 ZNF117 ZNF33B ZNF391 ZNF41 ZNF257 ZNF728 ZNF254 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF83 ZNF91 ZNF107 ZNF714 ZNF726 ZNF595 ZNF124 ZNF44 ZNF3	2.67e-14	693	76	22	PF00096
Domain	KRAB	ZNF33B ZNF41 ZNF257 ZNF728 ZNF254 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF91 ZNF738 ZNF726 ZNF595 ZNF124 ZNF44 ZNF3	5.97e-14	358	76	17	PF01352
Domain	-	ZNF676 ZNF117 ZNF33B ZNF391 ZNF41 ZNF257 ZNF728 ZNF254 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF83 ZNF91 ZNF107 ZNF714 ZNF726 ZNF124 ZNF44 ZNF3	1.94e-13	679	76	21	3.30.160.60
Domain	ZINC_FINGER_C2H2_2	ZNF676 ZNF117 ZNF33B ZNF391 ZNF41 ZNF257 ZNF728 ZNF254 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF83 ZNF91 ZNF107 ZNF714 ZNF726 ZNF595 ZNF124 ZNF44 ZNF3	2.57e-13	775	76	22	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF676 ZNF117 ZNF33B ZNF391 ZNF41 ZNF257 ZNF728 ZNF254 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF83 ZNF91 ZNF107 ZNF714 ZNF726 ZNF595 ZNF124 ZNF44 ZNF3	2.70e-13	777	76	22	PS00028
Domain	Znf_C2H2/integrase_DNA-bd	ZNF676 ZNF117 ZNF33B ZNF391 ZNF41 ZNF257 ZNF728 ZNF254 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF83 ZNF91 ZNF107 ZNF714 ZNF726 ZNF124 ZNF44 ZNF3	2.95e-13	694	76	21	IPR013087
Domain	Znf_C2H2	ZNF676 ZNF117 ZNF33B ZNF391 ZNF41 ZNF257 ZNF728 ZNF254 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF83 ZNF91 ZNF107 ZNF714 ZNF726 ZNF595 ZNF124 ZNF44 ZNF3	5.49e-13	805	76	22	IPR007087
Domain	ZnF_C2H2	ZNF676 ZNF117 ZNF33B ZNF391 ZNF41 ZNF257 ZNF728 ZNF254 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF83 ZNF91 ZNF107 ZNF714 ZNF726 ZNF595 ZNF124 ZNF44 ZNF3	5.91e-13	808	76	22	SM00355
Domain	Znf_C2H2-like	ZNF676 ZNF117 ZNF33B ZNF391 ZNF41 ZNF257 ZNF728 ZNF254 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF83 ZNF91 ZNF107 ZNF714 ZNF726 ZNF124 ZNF44 ZNF3	4.06e-12	796	76	21	IPR015880
Domain	zf-C2H2_6	ZNF676 ZNF117 ZNF391 ZNF728 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF91 ZNF107 ZNF714 ZNF726 ZNF44	2.91e-11	314	76	14	PF13912
Domain	Hy-lIII	MMD MMD2	1.63e-05	2	76	2	IPR005744
Domain	fn3	BOC FNDC1 LRRN3 PTPRB TEK	5.19e-04	162	76	5	PF00041
Domain	AdipoR/HlyIII-related	MMD MMD2	8.78e-04	11	76	2	IPR004254
Domain	HlyIII	MMD MMD2	8.78e-04	11	76	2	PF03006
Domain	FN3	BOC FNDC1 LRRN3 PTPRB TEK	9.45e-04	185	76	5	SM00060
Domain	FN3	BOC FNDC1 LRRN3 PTPRB TEK	1.31e-03	199	76	5	PS50853
Domain	FN3_dom	BOC FNDC1 LRRN3 PTPRB TEK	1.62e-03	209	76	5	IPR003961
Domain	CH	SYNE1 SPTBN2 NAV2	2.36e-03	65	76	3	SM00033
Domain	CH	SYNE1 SPTBN2 NAV2	2.91e-03	70	76	3	PF00307
Domain	-	SYNE1 SPTBN2 NAV2	3.03e-03	71	76	3	1.10.418.10
Domain	CH	SYNE1 SPTBN2 NAV2	3.28e-03	73	76	3	PS50021
Domain	4_helix_cytokine-like_core	ZNF254 ZNF506 ZNF85	3.41e-03	74	76	3	IPR009079
Domain	CH-domain	SYNE1 SPTBN2 NAV2	3.54e-03	75	76	3	IPR001715
Domain	Actinin_actin-bd_CS	SYNE1 SPTBN2	3.91e-03	23	76	2	IPR001589
Domain	Spectrin	SYNE1 SPTBN2	3.91e-03	23	76	2	PF00435
Domain	ACTININ_2	SYNE1 SPTBN2	3.91e-03	23	76	2	PS00020
Domain	ACTININ_1	SYNE1 SPTBN2	3.91e-03	23	76	2	PS00019
Domain	Spectrin_repeat	SYNE1 SPTBN2	6.18e-03	29	76	2	IPR002017
Domain	Spectrin/alpha-actinin	SYNE1 SPTBN2	7.49e-03	32	76	2	IPR018159
Domain	SPEC	SYNE1 SPTBN2	7.49e-03	32	76	2	SM00150
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF717 ZNF676 ZNF33B ZNF41 ZNF257 ZNF254 ZNF724 ZNF506 ZNF737 ZNF208 ZNF431 ZNF738 ZNF714 ZNF726 ZNF595 ZNF124 ZNF3	3.45e-05	1387	59	17	M734
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF33B ZNF41 ZNF257 ZNF728 ZNF724 ZNF737 ZNF208 ZNF91 ZNF107 ZNF738 ZNF726 ZNF595 ZNF124 ZNF44	8.64e-18	181	81	14	37372979
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF254 ZNF506 ZNF208 ZNF85 ZNF91 ZNF107 ZNF726 ZNF595	2.50e-15	29	81	8	14563677
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF254 ZNF208 ZNF91 ZNF107 ZNF726 ZNF595	6.50e-13	15	81	6	15885501
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF737 ZNF208 ZNF85 ZNF91 ZNF107	2.59e-10	16	81	5	8467795
Pubmed	The human genome contains hundreds of genes coding for finger proteins of the Krüppel type.	ZNF117 ZNF85 ZNF83 ZNF91	4.08e-10	6	81	4	2505992
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF208 ZNF85 ZNF91 ZNF107 ZNF726	1.06e-07	49	81	5	9630514
Pubmed	A pair of mouse KRAB zinc finger proteins modulates multiple indicators of female reproduction.	ZNF254 ZNF726 ZNF595	1.21e-07	5	81	3	20042539
Pubmed	The KRAB zinc finger protein RSL1 modulates sex-biased gene expression in liver and adipose tissue to maintain metabolic homeostasis.	ZNF254 ZNF726 ZNF595	1.21e-07	5	81	3	24190968
Pubmed	The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons.	ZNF254 ZNF726 ZNF595	2.42e-07	6	81	3	30846446
Pubmed	The KRAB zinc finger protein RSL1 regulates sex- and tissue-specific promoter methylation and dynamic hormone-responsive chromatin configuration.	ZNF254 ZNF726 ZNF595	4.23e-07	7	81	3	22801370
Pubmed	The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.	ZNF117 ZNF85 ZNF91	6.76e-07	8	81	3	2023909
Pubmed	Comparative analysis of KRAB zinc finger proteins in rodents and man: evidence for several evolutionarily distinct subfamilies of KRAB zinc finger genes.	ZNF254 ZNF726 ZNF595	1.01e-06	9	81	3	10360839
Pubmed	Functional analysis of the SRY-KRAB interaction in mouse sex determination.	ZNF208 ZNF91 ZNF107	1.44e-06	10	81	3	18588511
Pubmed	Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.	ZNF208 ZNF91 ZNF107	1.98e-06	11	81	3	15469996
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	ZNF391 SYNE1 SCN10A AKAP13 CCDC168 QSOX2	2.79e-06	168	81	6	30631154
Pubmed	Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.	ZNF208 ZNF91 ZNF107	3.42e-06	13	81	3	19850934
Pubmed	Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells.	PTPRB TEK	5.36e-06	2	81	2	19116766
Pubmed	Shear stress control of vascular leaks and atheromas through Tie2 activation by VE-PTP sequestration.	PTPRB TEK	5.36e-06	2	81	2	36740996
Pubmed	Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma.	PTPRB TEK	5.36e-06	2	81	2	31621585
Pubmed	Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature.	PTPRB TEK	5.36e-06	2	81	2	25180601
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF254 ZNF726 ZNF595	1.35e-05	20	81	3	2542606
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF254 ZNF726 ZNF595	1.35e-05	20	81	3	7479878
Pubmed	Heterogeneity of endothelial VE-PTP downstream polarization, Tie2 activation, junctional claudin-5, and permeability in the aorta and vena cava.	PTPRB TEK	1.60e-05	3	81	2	38032480
Pubmed	Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2.	PTPRB TEK	1.60e-05	3	81	2	10557082
Pubmed	VE-PTP controls blood vessel development by balancing Tie-2 activity.	PTPRB TEK	1.60e-05	3	81	2	19451274
Pubmed	Vascular Endothelial Receptor Tyrosine Phosphatase: Identification of Novel Substrates Related to Junctions and a Ternary Complex with EPHB4 and TIE2.	PTPRB TEK	1.60e-05	3	81	2	31427368
Pubmed	Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin.	PTPRB TEK	1.60e-05	3	81	2	26642851
Pubmed	A human MAP kinase interactome.	CEP350 MAP4K5 SYNE1 SPTBN2 NAV2 HELZ AKAP13 ZNF83	1.81e-05	486	81	8	20936779
Pubmed	Members of the zinc finger protein gene family sharing a conserved N-terminal module.	ZNF41 ZNF3	3.20e-05	4	81	2	1945843
Pubmed	A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.	FNDC1 LIPA	3.20e-05	4	81	2	21606135
Pubmed	Multiple genes encoding zinc finger domains are expressed in human T cells.	ZNF33B ZNF44 ZNF3	5.22e-05	31	81	3	2288909
Pubmed	PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus.	MMD MMD2	7.99e-05	6	81	2	21968647
Pubmed	Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB.	ZNF257 ZNF254	7.99e-05	6	81	2	10585455
Pubmed	Pancreatic expression and mitochondrial localization of the progestin-adipoQ receptor PAQR10.	MMD MMD2	7.99e-05	6	81	2	18769639
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	TRPM6 ZNF257 ZNF506 ZNF91 ZNF107 ZNF714 ZNF726	8.96e-05	451	81	7	36168627
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	IBTK KDM5C ZNF254 ZNF506 ZNF208 ZNF91 ZNF726 ZNF595 ZNF3	1.11e-04	808	81	9	20412781
Pubmed	Tagging genes with cassette-exchange sites.	ZNF254 NAV2 HELZ AKAP13 ZNF726 ZNF595	1.35e-04	335	81	6	15741177
Pubmed	Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP.	PTPRB TEK	1.49e-04	8	81	2	29358379
Pubmed	Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis.	PTPRB TEK	1.91e-04	9	81	2	20018779
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	KANSL1L XIRP2 SYNE1 ICA1 ABCC5	2.19e-04	233	81	5	37704626
Pubmed	PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif.	MMD MMD2	2.91e-04	11	81	2	16044242
Pubmed	Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.	ZNF254 ZNF726 ZNF595	3.97e-04	61	81	3	8662221
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	XIRP2 MAP4K5 APC2 SCN10A AKAP13 PICALM	5.12e-04	430	81	6	35044719
Pubmed	Functional Analysis of Mmd2 and Related PAQR Genes During Sex Determination in Mice.	MMD MMD2	5.52e-04	15	81	2	35306493
Pubmed	Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development.	PTPRB TEK	8.00e-04	18	81	2	16514057
Pubmed	An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.	SCN10A WDR48	8.00e-04	18	81	2	31666509
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TRPM6 CYP17A1 ICA1 ZNF254 DCAF17 NLRP4 ZNF726 ZNF595 QSOX2	9.39e-04	1084	81	9	11544199
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	XIRP2 SYNE1	9.91e-04	20	81	2	21689717
Pubmed	NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.	TRHDE ZNF717 PTPRB SYNE1 SPTBN2	1.10e-03	333	81	5	32665550
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	CEP350 TBRG4 ICA1 ZNF724 AKAP13 PICALM WDR48	1.14e-03	689	81	7	36543142
Pubmed	DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.	DCAF17 WDR81 WDR48	1.63e-03	99	81	3	34161765
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SYNE1 NAV2 TRIOBP WDR48	1.92e-03	225	81	4	12168954
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	EVI5 ZNF391 MAP4K5 ZNF254 ABCC5 ZNF714 ZNF726 PICALM ZNF44	2.06e-03	1215	81	9	15146197
Pubmed	Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2.	NAV2 RGS10	2.09e-03	29	81	2	16966370
Pubmed	Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.	CLCN5 MMD	2.23e-03	30	81	2	28077597
Interaction	TRIM28 interactions	ZNF33B ZNF41 ZNF257 ZNF728 KDM5C ZNF254 ZNF724 ZNF737 ZNF208 ZNF85 ZNF91 TBC1D23 ZNF107 ZNF738 ZNF726 ZNF595 ZNF124 ZNF44	1.00e-05	1474	78	18	int:TRIM28
Interaction	LTBP2 interactions	ZNF254 ZNF724 ZNF431 ZNF107 ZNF714	1.96e-05	85	78	5	int:LTBP2
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF676 ZNF257 ZNF728 ZNF254 ZNF724 ZNF737 ZNF208 ZNF431 ZNF85 ZNF91 ZNF738 ZNF714 ZNF726	4.63e-20	122	80	13	chr19p12
Cytoband	19p12	ZNF676 ZNF728 ZNF254 ZNF724 ZNF737 ZNF208 ZNF431 ZNF85 ZNF91 ZNF738 ZNF714 ZNF726	8.12e-20	90	80	12	19p12
Cytoband	12q15-q21	TRHDE PTPRB	8.99e-06	3	80	2	12q15-q21
Cytoband	6q25	FNDC1 SYNE1	1.96e-04	12	80	2	6q25
Cytoband	7q22.1	GJC3 STAG3 ZNF3	1.04e-03	113	80	3	7q22.1
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF717 ZNF676 ZNF117 ZNF33B ZNF391 ZNF41 ZNF257 ZNF728 ZNF254 ZNF506 ZNF737 ZNF208 ZNF431 ZNF85 ZNF83 ZNF91 ZNF107 ZNF714 ZNF726 ZNF595 ZNF124 ZNF44 ZNF3	5.84e-17	718	62	23	28
GeneFamily	Fibronectin type III domain containing	BOC FNDC1 LRRN3 PTPRB TEK	2.20e-04	160	62	5	555
GeneFamily	Progestin and adipoQ receptor family	MMD MMD2	6.24e-04	11	62	2	930
Coexpression	MIKKELSEN_NPC_ICP_WITH_H3K4ME3	LRRN3 LIPA CLCN5 ZNF254 ZNF208 ZNF85 ZNF91 ZNF107 ZNF726 ZNF595	2.76e-06	497	80	10	MM863
Coexpression	DURAND_STROMA_NS_UP	ICA1 ZNF208 ZNF85 ZNF91 ZNF107 STAG3	2.90e-05	194	80	6	MM962
Coexpression	GSE20152_SPHK1_KO_VS_HTNFA_OVEREXPRESS_ANKLE_DN	CEP350 KANSL1L ZNF33B SYNE1 ABCC5 AARSD1	3.16e-05	197	80	6	M7683
Coexpression	MIKKELSEN_ES_ICP_WITH_H3K4ME3	LIPA CLCN5 ZNF254 ZNF208 ZNF85 ZNF91 TEK ZNF107 ZNF726 ZNF595 ZNF44	3.33e-05	807	80	11	MM855
Coexpression	GSE38697_LIGHT_ZONE_VS_DARK_ZONE_BCELL_DN	TRHDE BOC LOXL4 RPS6KL1 MMD2	4.96e-05	130	80	5	M9010
Coexpression	ZWANG_DOWN_BY_2ND_EGF_PULSE	ZNF717 ZNF117 ZNF724 ZNF431 ZNF107 ZNF738 ZNF714	5.72e-05	321	80	7	M2615
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8\|TCGA-Bladder / Sample_Type by Project: Shred V9	ZNF254 ZNF737 ZNF107 ZNF738 ZNF714 ZNF726	3.28e-07	150	81	6	1aa9320d97ff10994ea024751790524fe133aba9
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 CLCN5 ICA1 NAV2 ABCC5 ZNF83	4.13e-07	156	81	6	4d2679e7639758c49fc25a2deb9109b08f0a3e57
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SCFD2 CEP350 ZNF33B ZNF391 RPS6KL1	1.07e-05	159	81	5	ba82d1f55dd77c4b2183981b76cab1480fba75ad
Drug	Cyanocobalamin [68-19-9]; Up 200; 3uM; PC3; HT_HG-U133A	KANSL1L LRRN3 AK5 KDM5C SCN10A STAG3 RGS10 ZNF44	4.20e-07	197	79	8	4572_UP
Drug	milbemycin	SYNE1 MMD	1.19e-05	2	79	2	CID006440579
Drug	cumene	BOC MAP4K5 SCN10A LOXL4	2.53e-05	49	79	4	CID000007406
Drug	bromoethyl acetate	BOC SYNE1	3.56e-05	3	79	2	CID000013564
Drug	dimethylformamide	BOC SYNE1 NLRP4 MMD	4.94e-05	58	79	4	CID000006228
Drug	Letrozole [112809-51-5]; Down 200; 14uM; PC3; HT_HG-U133A	ZNF117 PTPRB AK5 KDM5C SPTBN2 ZNF44	5.71e-05	193	79	6	4240_DN
Drug	Pirenzepine dihydrochloride [29868-97-1]; Down 200; 9.4uM; PC3; HT_HG-U133A	CLCN5 KDM5C ZNF254 AKAP13 ZNF124 WDR48	6.04e-05	195	79	6	2071_DN
Drug	Mafenide hydrochloride [138-37-4]; Down 200; 18uM; MCF7; HT_HG-U133A	CLCN5 ICA1 ZNF254 PICALM RGS10 WDR48	6.22e-05	196	79	6	5499_DN
Drug	6-Hydroxytropinone [5932-53-6]; Up 200; 25.8uM; MCF7; HT_HG-U133A	ICA1 SPTBN2 SCN10A HELZ AKAP13 ZNF3	6.22e-05	196	79	6	4833_UP
Drug	Guaifenesin [93-14-1]; Down 200; 20.2uM; HL60; HT_HG-U133A	EVI5 SYNE1 KDM5C SH3BP2 ICA1 ZNF44	6.40e-05	197	79	6	2569_DN
Drug	nordihydroguaiaretic acid; Up 200; 1uM; MCF7; HT_HG-U133A	LRRN3 MAP4K5 CYP17A1 KDM5C SH3BP2 STAG3	6.58e-05	198	79	6	1648_UP
Drug	Phenethicillin potassium salt [132-93-4]; Up 200; 10uM; MCF7; HT_HG-U133A	CEP350 KANSL1L MAP4K5 SH3BP2 SCN10A ZNF124	6.58e-05	198	79	6	6239_UP
Drug	Atropine-N-oxide hydrochloride [4574-60-1]; Down 200; 11.8uM; PC3; HT_HG-U133A	CEP350 EVI5 CLCN5 KDM5C SH3BP2 WDR48	6.58e-05	198	79	6	2054_DN
Drug	Dihydrostreptomycin sulfate [5490-27-7]; Down 200; 2.8uM; PC3; HT_HG-U133A	CLCN5 KDM5C SH3BP2 ABCC5 AKAP13 STAG3	6.58e-05	198	79	6	2074_DN
Drug	Propidium iodide [25535-16-4]; Down 200; 6uM; HL60; HT_HG-U133A	KANSL1L LRRN3 CYP17A1 ZNF254 SCN10A ZNF44	6.58e-05	198	79	6	2541_DN
Drug	Adenosine 5'-monophosphate monohydrate [18422-05-4]; Up 200; 11uM; MCF7; HT_HG-U133A	EVI5 KANSL1L CYP17A1 TRIOBP STAG3 RGS10	6.76e-05	199	79	6	5359_UP
Drug	Procyclidine hydrochloride [1508-76-5]; Down 200; 12.4uM; MCF7; HT_HG-U133A	MAP4K5 KDM5C ZNF254 ZNF107 MMD PICALM	6.76e-05	199	79	6	4817_DN
Drug	Atracurium besylate [64228-81-5]; Down 200; 3.2uM; MCF7; HT_HG-U133A	EVI5 KANSL1L KDM5C ICA1 TRIOBP WDR48	6.76e-05	199	79	6	1702_DN
Drug	Androsterone [53-41-8]; Down 200; 13.8uM; PC3; HT_HG-U133A	SH3BP2 ICA1 ZNF254 ZNF208 RGS10 ZNF44	6.76e-05	199	79	6	4635_DN
Drug	Tropicamide [1508-75-4]; Down 200; 14uM; HL60; HT_HG-U133A	ICA1 ZNF85 ZNF83 STAG3 RGS10 WDR48	6.76e-05	199	79	6	2347_DN
Drug	2-iodoaniline	BOC SYNE1	7.10e-05	4	79	2	CID000011995
Disease	Uterine leiomyoma	SCFD2 ZNF257 SYNE1 ZNF208	1.12e-04	91	80	4	HP_0000131
Disease	episodic memory	CEP350 TRHDE TRPM6	3.85e-04	52	80	3	EFO_0004333
Disease	non-high density lipoprotein cholesterol measurement	EVI5 LIPA MAP4K5 WDR81 ZNF737 ATG4C HELZ QSOX2	7.01e-04	713	80	8	EFO_0005689
Disease	Neuralgia, Supraorbital	CYP17A1 SCN10A	8.50e-04	16	80	2	C0038870
Disease	Neuralgia, Iliohypogastric Nerve	CYP17A1 SCN10A	8.50e-04	16	80	2	C0423712
Disease	Neuralgia, Perineal	CYP17A1 SCN10A	8.50e-04	16	80	2	C0423711
Disease	Neuralgia	CYP17A1 SCN10A	8.50e-04	16	80	2	C0027796
Disease	Neuralgia, Atypical	CYP17A1 SCN10A	8.50e-04	16	80	2	C0234247
Disease	Neuralgia, Stump	CYP17A1 SCN10A	8.50e-04	16	80	2	C0234249
Disease	Paroxysmal Nerve Pain	CYP17A1 SCN10A	8.50e-04	16	80	2	C0751373
Disease	Nerve Pain	CYP17A1 SCN10A	8.50e-04	16	80	2	C0751372
Disease	Neuralgia, Ilioinguinal	CYP17A1 SCN10A	8.50e-04	16	80	2	C0751371
Disease	Neuralgia, Vidian	CYP17A1 SCN10A	8.50e-04	16	80	2	C0042656
Disease	Hemangiosarcoma	PTPRB TEK	1.08e-03	18	80	2	C0018923
Disease	level of Phosphatidylinositol (18:0_20:4) in blood serum	MAP4K5 ATG4C	1.77e-03	23	80	2	OBA_2045158
Disease	diacylglycerol 34:1 measurement	MAP4K5 ZNF254	1.93e-03	24	80	2	EFO_0010352
Disease	response to TNF antagonist, joint damage measurement	NAV2 ZNF595	2.09e-03	25	80	2	EFO_0004653, EFO_0005413
Disease	uterine fibroid	SCFD2 ZNF257 SYNE1 ZNF208	2.13e-03	199	80	4	EFO_0000731

Protein segments in the cluster

Peptide	Gene	Start	Entry
SHVSSEAIIWVSNKS	TRHDE	651	Q9UKU6
ETESSAVKWTHTKHS	nan	131	A4D1N5
CQESTKFKNVWTTHS	DCAF17	41	Q5H9S7
AFKHKTKVWSLTSSS	ADGRD1	816	Q6QNK2
ISKKHRTWFFSASSE	SH3BP2	101	P78314
NTWKFLSHSTDSLNK	AKAP13	1921	Q12802
TAVADHLFKLKTTSW	AARSD1	116	Q9BTE6
SIWTSTISSHLATKH	QDPR	111	P09417
SESWTSHTVKKFTAS	ATG4C	146	Q96DT6
SLWKLFHTLTVEAST	QSOX2	431	Q6ZRP7
SSSHQSLKSTAKWAA	RGS10	26	O43665
STSAAWKAHSTASEK	KCTD19	681	Q17RG1
RHKAFSTWASHLTSI	OR5D14	236	Q8NGL3
TWKHKSSSSKYFLTS	GJC3	221	Q8NFK1
LAESKASSHSVSIQW	PTPRB	31	P23467
VVSTVFHTISWKKSH	MMD2	81	Q8IY49
SSSSSWLLNQKHSKK	KANSL1L	526	A0AUZ9
KSLTNKNSFWIHQVT	LOXL4	236	Q96JB6
IHSTSSNRKWSLIAK	AK5	171	Q9Y6K8
AWASSLHSVSSKSFR	IBTK	1191	Q9P2D0
KLSSTLSWVKNTVSH	EVI5	26	O60447
KFSRLWSSKSVTEIH	NLRP4	106	Q96MN2
TVSTKKSHQTWTFAL	HELZ	271	P42694
STVFHIVSWKKSHLR	MMD	76	Q15546
TFSWLSSLARVAHKK	ABCC5	111	O15440
KSVLSALWNLSAHST	APC2	551	O95996
KHRKVTNSSDDWTIS	BOC	511	Q9BWV1
IRNKWSTQASSVTHL	FNDC1	1701	Q4ZHG4
TTTSVVKWTLAFLLH	CYP17A1	306	P05093
ITNKSKESTWALIHS	CLCN5	106	P51795
HRSETAKNWKSLTES	CEP350	2141	Q5VT06
SKWKKSVFSHILNTS	CCDC168	3576	Q8NDH2
LAWVAHKTLTSSATS	TBRG4	31	Q969Z0
WSSTFHNFVKIALTK	MAP4K5	246	Q9Y4K4
DTSKWKRTAKCHTSS	PCARE	141	A6NGG8
TTLLHFWEKTSHTMA	ICA1	236	Q05084
HWSLISSQTTERFSK	SYNE1	7436	Q8NF91
SVKWTAFVKTENSHA	LRRN3	551	Q9H3W5
WRSKSLSVKHSATVS	NAV2	381	Q8IVL1
DWDSSINLTFHKSKI	SCFD2	521	Q8WU76
TTSTSQWKKHWFVLT	TRIOBP	1801	Q9H2D6
SWVVVFKSLITTHHL	PICALM	71	Q13492
KGNVKTSTWLFETHT	XIRP2	1271	A4UGR9
FKWFSTLTRHKRIHT	ZNF431	241	Q8TF32
FNWSSTLTKHKRIHT	ZNF431	381	Q8TF32
FNWFSTLTKHKRIHT	ZNF107	141	Q9UII5
FKWFSTLTRHKRIHT	ZNF738	241	Q8NE65
AFTWSSSLNKHKRIH	ZNF595	376	Q8IYB9
FNWSSSLTKHKIIHT	ZNF595	601	Q8IYB9
FNWSSTLTKHKRIHT	ZNF714	321	Q96N38
KAFSWSSSLTEHKRI	ZNF676	316	Q8N7Q3
KAFTWSSSFTKHKRI	ZNF676	456	Q8N7Q3
FNWSSTLTKHKVIHT	ZNF724	571	A8MTY0
KTFSWSSTLTHHQRI	ZNF3	291	P17036
FWEKSNLTKHQRSHT	ZNF33B	366	Q06732
ISASSDTTVKVWNAH	WDR48	91	Q8TAF3
LKSHSSHSLRKIWTV	TRPM6	191	Q9BX84
HFVSSSSDKSVKVWD	WDR61	246	Q9GZS3
KTFTKWVNSHLARVT	SPTBN2	61	O15020
FSILWTLTHISKSDA	STAG3	751	Q9UJ98
RTAIKVSVHSWFSLF	SCN10A	121	Q9Y5Y9
KSRNIKYSTSLSWIH	TBC1D23	116	Q9NUY8
FSWSSSLTTHKAIHA	ZNF728	461	P0DKX0
SKLKSHPFFSTIQWS	RPS6KL1	531	Q9Y6S9
FSVASTVKHALSIWL	SLC35E2B	326	P0CK96
KISNITHSSAVISWT	TEK	646	Q02763
AFSRASTLWKHKKTH	ZNF124	326	Q15973
HISWKASIQGFSSKI	TRGV11	36	A0A075B6L2
KTFHRKSFLTIHQWT	ZNF717	486	Q9BY31
NWSSTLTNHKKTHTE	ZNF726	211	A6NNF4
SFIWSSTLFKHKRIH	ZNF726	601	A6NNF4
EKTFHWSSTLTNHKE	ZNF91	216	Q05481
KAFNWSSSLTKHKRF	ZNF91	441	Q05481
FNWSSSLTKHKRIHT	ZNF91	751	Q05481
FIWSSTLTEHKRIHT	ZNF91	891	Q05481
TFTWKSRLNIHQKSH	ZNF41	741	P51814
FSWLSVFSKHKKTHA	ZNF208	926	O43345
KWSSTLSYHKKIHTV	ZNF208	1151	O43345
FNWSSTLNKHKRIHT	ZNF117	146	Q03924
FNWSSTLTKHKRIHT	ZNF85	211	Q03923
SSLSSFNRHKRTHWK	ZNF44	646	P15621
VLVSSSSDHSLTVWK	WDR81	1841	Q562E7
TWYSSLSKHKRAHTG	ZNF506	351	Q5JVG8
AFNWSSTLTKHKIIH	ZNF254	526	O75437
FFWSSTLTKHKRIHT	ZNF254	611	O75437
KVFSHKSSLVNHWRI	ZNF83	296	P51522
KAFSWISSLTEHQRT	ZNF391	256	Q9UJN7
WSSALTTLTQHKRIH	ZNF257	296	Q9Y2Q1
KAFNWSSHLTTHKRI	ZNF737	376	O75373
LTAHSWREKASKTFL	KDM5C	1076	P41229
SRKHKTLSVSQDEFW	LIPA	126	P38571