Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondiacylglycerol binding

DGKD UNC13C RAPGEF2

2.64e-0516743GO:0019992
GeneOntologyMolecularFunctioncytoskeletal motor activity

KIF3B MYO5B MYH15 KIF5A DNAH9

7.70e-05118745GO:0003774
GeneOntologyMolecularFunctioncytoskeletal protein binding

GAS2L1 TRIM2 KIF3B EML5 MYO5B FMN1 SPTAN1 APC MYH15 SORBS1 KIF5A HTT MPRIP

1.81e-0410997413GO:0008092
GeneOntologyMolecularFunctionstructural constituent of presynaptic active zone

ERC1 ERC2

3.74e-048742GO:0098882
GeneOntologyBiologicalProcesssynaptic signaling

MYO5B PTPRS ELFN1 ERC1 ERC2 UNC13C SORBS1 KIF5A RAPGEF2 SLC24A1 SLC7A11 HTT RIC3 GABRA2 GABRA4

2.27e-069767615GO:0099536
GeneOntologyBiologicalProcesscanonical Wnt signaling pathway involved in negative regulation of apoptotic process

TCF7 APC

1.34e-052762GO:0044336
GeneOntologyBiologicalProcessanterograde trans-synaptic signaling

MYO5B PTPRS ERC1 ERC2 UNC13C KIF5A RAPGEF2 SLC24A1 SLC7A11 HTT RIC3 GABRA2 GABRA4

3.23e-059317613GO:0098916
GeneOntologyBiologicalProcesschemical synaptic transmission

MYO5B PTPRS ERC1 ERC2 UNC13C KIF5A RAPGEF2 SLC24A1 SLC7A11 HTT RIC3 GABRA2 GABRA4

3.23e-059317613GO:0007268
GeneOntologyBiologicalProcesstrans-synaptic signaling

MYO5B PTPRS ERC1 ERC2 UNC13C KIF5A RAPGEF2 SLC24A1 SLC7A11 HTT RIC3 GABRA2 GABRA4

3.53e-059397613GO:0099537
GeneOntologyBiologicalProcesscell junction organization

MYO5B PTPRS ELFN1 ERC1 FMN1 CLDN16 APC ERC2 SORBS1 RAPGEF2 SLC7A11 GABRA2 GABRA4

5.15e-059747613GO:0034330
GeneOntologyBiologicalProcessregulation of glutamate metabolic process

APC SLC7A11

8.00e-054762GO:2000211
GeneOntologyBiologicalProcesspositive regulation of plasma membrane bounded cell projection assembly

SEPTIN9 TENM1 APC HTT PLCE1

9.15e-05123765GO:0120034
GeneOntologyBiologicalProcessvesicle cytoskeletal trafficking

KIF3B MYO5B KIF5A HTT

1.09e-0467764GO:0099518
GeneOntologyBiologicalProcessmaintenance of presynaptic active zone structure

ERC1 ERC2

1.99e-046762GO:0048790
GeneOntologyBiologicalProcesssynaptic vesicle priming

ERC1 ERC2 UNC13C

2.01e-0431763GO:0016082
GeneOntologyBiologicalProcesssynapse organization

MYO5B PTPRS ELFN1 ERC1 ERC2 SORBS1 RAPGEF2 SLC7A11 GABRA2 GABRA4

2.02e-046857610GO:0050808
GeneOntologyBiologicalProcessamino acid metabolic process

AUH HPD GART APC SLC7A11 DARS2 HTT

2.22e-04332767GO:0006520
GeneOntologyBiologicalProcesscell junction assembly

PTPRS ELFN1 FMN1 CLDN16 APC SORBS1 RAPGEF2 GABRA2 GABRA4

2.39e-04569769GO:0034329
GeneOntologyBiologicalProcessregulation of calcium-dependent activation of synaptic vesicle fusion

ERC1 ERC2

2.78e-047762GO:0150037
GeneOntologyBiologicalProcessanterograde dendritic transport of neurotransmitter receptor complex

KIF3B KIF5A

2.78e-047762GO:0098971
GeneOntologyBiologicalProcessalpha-amino acid metabolic process

AUH HPD GART APC SLC7A11 HTT

3.28e-04251766GO:1901605
GeneOntologyBiologicalProcessregulation of glutamine family amino acid metabolic process

APC SLC7A11

3.70e-048762GO:0000820
GeneOntologyCellularComponentcytoplasmic region

KIF3B MYO5B ERC1 SEPTIN9 WDR35 ERC2 UNC13C KIF5A DNAH9 HTT

7.05e-073607610GO:0099568
GeneOntologyCellularComponentcell cortex region

MYO5B ERC1 ERC2 UNC13C

2.15e-0545764GO:0099738
GeneOntologyCellularComponentsomatodendritic compartment

KIF3B MYO5B PTPRS ELFN1 APC KCNN3 ERC2 KIF5A RAPGEF2 SLC24A1 TRIM3 HTT RIC3 GABRA2 GABRA4

3.02e-0512287615GO:0036477
GeneOntologyCellularComponentcell cortex

MYO5B ERC1 SEPTIN9 SPTAN1 APC ERC2 UNC13C KDF1

6.01e-05371768GO:0005938
GeneOntologyCellularComponentpostsynapse

KIF3B MYO5B PTPRS ELFN1 ERC1 SPTAN1 APC KIF5A RAPGEF2 TRIM3 HTT GABRA2 GABRA4

7.05e-0510187613GO:0098794
GeneOntologyCellularComponentpresynaptic active zone cytoplasmic component

ERC1 ERC2 UNC13C

7.76e-0523763GO:0098831
GeneOntologyCellularComponentneuronal cell body

MYO5B PTPRS APC KCNN3 ERC2 KIF5A RAPGEF2 SLC24A1 HTT RIC3 GABRA2

2.07e-048357611GO:0043025
GeneOntologyCellularComponentactin cytoskeleton

ACTL7A GAS2L1 MYO5B FMN1 SEPTIN9 SPTAN1 MYH15 SORBS1 MPRIP

2.37e-04576769GO:0015629
GeneOntologyCellularComponentcytoskeleton of presynaptic active zone

ERC1 ERC2

3.60e-048762GO:0048788
GeneOntologyCellularComponentcell body

MYO5B PTPRS APC KCNN3 ERC2 KIF5A RAPGEF2 SLC24A1 HTT RIC3 GABRA2

5.12e-049297611GO:0044297
GeneOntologyCellularComponentcontractile actin filament bundle

GAS2L1 SEPTIN9 SORBS1 MPRIP

6.27e-04107764GO:0097517
GeneOntologyCellularComponentstress fiber

GAS2L1 SEPTIN9 SORBS1 MPRIP

6.27e-04107764GO:0001725
GeneOntologyCellularComponentmicrotubule

GAS2L1 CDK2AP2 KIF3B EML5 SEPTIN9 APC KIF5A DNAH9

6.98e-04533768GO:0005874
GeneOntologyCellularComponentglutamatergic synapse

KIF3B MYO5B PTPRS ELFN1 ERC1 SPTAN1 APC ERC2 TRIM3 HTT

7.28e-048177610GO:0098978
GeneOntologyCellularComponentactomyosin

GAS2L1 SEPTIN9 SORBS1 MPRIP

8.77e-04117764GO:0042641
GeneOntologyCellularComponentactin filament bundle

GAS2L1 SEPTIN9 SORBS1 MPRIP

9.05e-04118764GO:0032432
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

KIF3B SEPTIN9 WDR35 KIF5A DNAH9 HTT

1.04e-03317766GO:0032838
GeneOntologyCellularComponentpresynaptic cytoskeleton

ERC1 ERC2

1.15e-0314762GO:0099569
GeneOntologyCellularComponentsynaptic membrane

PTPRS ELFN1 ERC1 ERC2 UNC13C HTT GABRA2 GABRA4

1.24e-03583768GO:0097060
GeneOntologyCellularComponentaxon

KIF3B PTPRS ELFN1 SPTAN1 APC ERC2 UNC13C KIF5A HTT GABRA2

1.40e-038917610GO:0030424
GeneOntologyCellularComponentpresynaptic active zone

ERC1 ERC2 UNC13C GABRA2

1.75e-03141764GO:0048786
GeneOntologyCellularComponentcytosolic region

ERC1 KIF5A HTT

2.12e-0370763GO:0099522
GeneOntologyCellularComponentGABA-A receptor complex

GABRA2 GABRA4

2.14e-0319762GO:1902711
GeneOntologyCellularComponentGABA receptor complex

GABRA2 GABRA4

2.62e-0321762GO:1902710
GeneOntologyCellularComponentapical junction complex

CLDN16 APC SORBS1 RAPGEF2

2.64e-03158764GO:0043296
GeneOntologyCellularComponentGABA-ergic synapse

ERC1 ERC2 GABRA2 GABRA4

3.02e-03164764GO:0098982
GeneOntologyCellularComponentpresynaptic membrane

PTPRS ERC1 ERC2 UNC13C GABRA2

3.38e-03277765GO:0042734
GeneOntologyCellularComponentsupramolecular fiber

GAS2L1 CDK2AP2 KIF3B EML5 FMN1 SEPTIN9 SPTAN1 APC MYH15 KIF5A DNAH9

3.45e-0311797611GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

GAS2L1 CDK2AP2 KIF3B EML5 FMN1 SEPTIN9 SPTAN1 APC MYH15 KIF5A DNAH9

3.63e-0311877611GO:0099081
GeneOntologyCellularComponentdendrite

KIF3B MYO5B ELFN1 APC KIF5A TRIM3 HTT GABRA2 GABRA4

3.85e-03858769GO:0030425
GeneOntologyCellularComponentdendritic tree

KIF3B MYO5B ELFN1 APC KIF5A TRIM3 HTT GABRA2 GABRA4

3.91e-03860769GO:0097447
GeneOntologyCellularComponentexocytic vesicle membrane

PTPRS APC UNC13C GABRA2

4.13e-03179764GO:0099501
GeneOntologyCellularComponentsynaptic vesicle membrane

PTPRS APC UNC13C GABRA2

4.13e-03179764GO:0030672
GeneOntologyCellularComponentsynaptic vesicle

PTPRS ERC1 APC UNC13C GABRA2

4.74e-03300765GO:0008021
GeneOntologyCellularComponentdistal axon

PTPRS ELFN1 APC ERC2 UNC13C KIF5A

5.03e-03435766GO:0150034
GeneOntologyCellularComponentcilium

ACTL7A KIF3B ERC1 SEPTIN9 WDR35 B9D1 KIF5A CATSPERG DNAH9

5.18e-03898769GO:0005929
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

GAS2L1 CDK2AP2 KIF3B EML5 FMN1 SEPTIN9 APC KIF5A DNAH9

5.22e-03899769GO:0099513
GeneOntologyCellularComponentsecretory vesicle

ACTL7A PTPRB PTPRS ERC1 ADGRE3 SPTAN1 PSMB7 APC UNC13C PGM2 GABRA2

5.22e-0312467611GO:0099503
GeneOntologyCellularComponentexocytic vesicle

PTPRS ERC1 APC UNC13C GABRA2

6.21e-03320765GO:0070382
GeneOntologyCellularComponentpostsynaptic specialization membrane

PTPRS ELFN1 GABRA2 GABRA4

6.21e-03201764GO:0099634
DomainELKS/CAST

ERC1 ERC2

1.63e-052762IPR019323
DomainCast

ERC1 ERC2

1.63e-052762PF10174
DomainNHL

TRIM2 TENM1 TRIM3

1.80e-0513763PS51125
DomainGABAAa_rcpt

GABRA2 GABRA4

2.43e-046762IPR001390
Domain-

TRIM2 TENM1 TRIM3

5.33e-04397632.120.10.30
DomainNHL_repeat_subgr

TRIM2 TRIM3

5.77e-049762IPR013017
DomainIG_FLMN

TRIM2 TRIM3

7.20e-0410762SM00557
DomainNHL

TRIM2 TRIM3

7.20e-0410762PF01436
DomainNHL_repeat

TRIM2 TRIM3

7.20e-0410762IPR001258
Domain6-blade_b-propeller_TolB-like

TRIM2 TENM1 TRIM3

8.67e-0446763IPR011042
DomainFilamin

TRIM2 TRIM3

8.78e-0411762PF00630
DomainFILAMIN_REPEAT

TRIM2 TRIM3

8.78e-0411762PS50194
DomainFilamin/ABP280_rpt

TRIM2 TRIM3

8.78e-0411762IPR001298
DomainFilamin/ABP280_repeat-like

TRIM2 TRIM3

8.78e-0411762IPR017868
DomainBbox_C

TRIM2 TRIM3

1.66e-0315762IPR003649
DomainBBC

TRIM2 TRIM3

1.66e-0315762SM00502
DomainApc4_WD40_dom

EML5 WDR35

2.96e-0320762IPR024977
DomainANAPC4_WD40

EML5 WDR35

2.96e-0320762PF12894
DomainQuino_amine_DH_bsu

TRIM2 TRIM3

3.58e-0322762IPR011044
DomainGABAA/Glycine_rcpt

GABRA2 GABRA4

3.91e-0323762IPR006028
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

NCOR1 RANBP2 KIF3B PTPRS ERC1 SPTAN1 APC ERC2 SORBS1 KIF5A RAPGEF2 SLC4A4 HSPA9 TRIM3 MPRIP

2.28e-09963761528671696
Pubmed

Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.

ERC1 ERC2 UNC13C

3.49e-07776336398873
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

NCOR1 RANBP2 AUH FMN1 SEPTIN9 SPTAN1 APC RAPGEF2 HTT

9.72e-0747576931040226
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

LIFR EML5 ERC1 ARID5B HSPA9 HTT

1.07e-0615276634299191
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

PTPRB ERC1 SEPTIN9 SPTAN1 GART APC HSPA9 DARS2

1.25e-0636076833111431
Pubmed

Genetic mapping of three GABAA receptor-subunit genes in the mouse.

PGM2 GABRA2 GABRA4

2.17e-06127638390964
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

GAS2L1 MYO5B PTPRS ERC1 SEPTIN9 SPTAN1 APC ERC2 SORBS1 RAPGEF2 SLC4A4 HSPA9 TRIM3 MPRIP

2.36e-061431761437142655
Pubmed

Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors.

ELFN1 ERC1 ERC2

2.82e-061376336179691
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

NCOR1 RANBP2 TCF7 MYO5B ERAP2 SEPTIN9 SPTAN1 GART UGDH APC MED12 HSPA9 MPRIP

2.85e-061247761327684187
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

EHBP1 USP34 NCOR1 RANBP2 ERC1 ARID5B APC MED12

3.76e-0641876834709266
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

USP34 ERC1 SPTAN1 ARID5B APC ERC2 SORBS1 KIF5A RAPGEF2 MTMR10 HSPA9 STAT6 MPRIP

3.95e-061285761335914814
Pubmed

Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles.

NCOR1 HSPA9 HTT

4.48e-061576311092755
Pubmed

Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.

TCF7 APC

4.71e-06276210489374
Pubmed

ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains.

ERC1 ERC2

4.71e-06276227253063
Pubmed

The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles.

ERC1 ERC2

4.71e-06276223960145
Pubmed

Stat6 Promotes Intestinal Tumorigenesis in a Mouse Model of Adenomatous Polyposis by Expansion of MDSCs and Inhibition of Cytotoxic CD8 Response.

APC STAT6

4.71e-06276228654863
Pubmed

Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency.

TCF7 APC

4.71e-06276212226748
Pubmed

Double deletion of the active zone proteins CAST/ELKS in the mouse forebrain causes high mortality of newborn pups.

ERC1 ERC2

4.71e-06276231996256
Pubmed

The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages.

NCOR1 STAT6

4.71e-06276229343442
Pubmed

Two types of liver-specific F antigen are encoded by a locus located on chromosome 5 in mice.

HPD PGM2

4.71e-0627623666846
Pubmed

Altered SK3/KCa2.3-mediated migration in adenomatous polyposis coli (Apc) mutated mouse colon epithelial cells.

APC KCNN3

4.71e-06276220519134
Pubmed

Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence.

GABRA2 GABRA4

4.71e-06276219207358
Pubmed

CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CAST.

ERC1 ERC2

4.71e-06276214723704
Pubmed

TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation.

SLC7A11 TRIM3

4.71e-06276237978273
Pubmed

Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis.

APC PLCE1

4.71e-06276219458037
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

USP34 NCOR1 ERC1 ARID5B APC ERC2 SORBS1 CLSPN MPRIP

5.53e-0658876938580884
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

EHBP1 RANBP2 ELFN1 ERC1 SEPTIN9 SPTAN1 TENM1 APC SORBS1 SLC4A4 HSPA9 GABRA2

6.46e-061139761236417873
Pubmed

Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.

USP34 ERC1 WDR35 ERC2 SORBS1

9.35e-0612876530995482
Pubmed

A human MAP kinase interactome.

EHBP1 RANBP2 SPTAN1 APC SORBS1 KIF5A RAPGEF2 SLC4A4

1.13e-0548676820936779
Pubmed

HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron.

APC SLC7A11

1.41e-05376233914705
Pubmed

Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study.

GABRA2 GABRA4

1.41e-05376218482426
Pubmed

Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance.

ERC1 ERC2

1.41e-05376230190286
Pubmed

The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons.

ERC1 ERC2

1.41e-05376225209271
Pubmed

TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer.

TCF7 APC

1.41e-05376234385712
Pubmed

Modulation of GABAA receptor signaling increases neurogenesis and suppresses anxiety through NFATc4.

GABRA2 GABRA4

1.41e-05376224948817
Pubmed

Spatiotemporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis.

GABRA2 GABRA4

1.41e-05376221722213
Pubmed

The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular codistribution and translocation to the nuclear matrix.

TENM1 SORBS1

1.41e-05376215777793
Pubmed

Mutant huntingtin increases nuclear corepressor function and enhances ligand-dependent nuclear hormone receptor activation.

NCOR1 HTT

1.41e-05376212799135
Pubmed

Contribution of genes in the GABAergic pathway to bipolar disorder and its executive function deficit in the Chinese Han population.

GABRA2 GABRA4

1.41e-05376229135068
Pubmed

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.

STAT6 PLCE1

1.41e-05376227322543
Pubmed

ZNF545 loss promotes ribosome biogenesis and protein translation to initiate colorectal tumorigenesis in mice.

APC ZFP82

1.41e-05376234615997
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

ERC1 POLA1 SPTAN1 APC CLSPN MED12

1.55e-0524276634011540
Pubmed

Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.

ERC1 SPTAN1 RAPGEF2 HSPA9 TRIM3

1.83e-0514776516959763
Pubmed

Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.

ERC1 ERC2 UNC13C

2.51e-052676317124501
Pubmed

Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin.

NCOR1 HTT

2.82e-05476210441327
Pubmed

SAD-B Phosphorylation of CAST Controls Active Zone Vesicle Recycling for Synaptic Depression.

ERC1 ERC2

2.82e-05476227626661
Pubmed

Genome-Wide Association Mapping for Female Infertility in Inbred Mice.

SORBS1 PLCE1

2.82e-05476227449513
Pubmed

Nup358 interacts with APC and plays a role in cell polarization.

RANBP2 APC

2.82e-05476219654215
Pubmed

Identification of a link between the tumour suppressor APC and the kinesin superfamily.

KIF3B APC

2.82e-05476211912492
Pubmed

A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones.

ERC1 ERC2

2.82e-05476212391317
Pubmed

CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.

ERC1 ERC2

2.82e-05476229996090
Pubmed

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons.

KIF5A HTT

2.82e-05476218615096
Pubmed

Non-hematopoietic STAT6 induces epithelial tight junction dysfunction and promotes intestinal inflammation and tumorigenesis.

APC STAT6

2.82e-05476231534167
Pubmed

TRIM-NHL proteins in development and disease.

TRIM2 TRIM3

2.82e-05476226514622
Pubmed

Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking.

ERC1 ERC2

2.82e-05476227537483
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

EHBP1 ERC1 FMN1 SEPTIN9 SPTAN1 SORBS1 KDF1 MPRIP

3.30e-0556576825468996
Pubmed

Human variation in alcohol response is influenced by variation in neuronal signaling genes.

PTPRB ERC1 ERC2 SORBS1 PLCE1

3.78e-0517176520201926
Pubmed

Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry.

RANBP2 KIF5A

4.69e-05576220386726
Pubmed

ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.

ERC1 ERC2

4.69e-05576232521280
Pubmed

GABAA receptor signaling in caudal periaqueductal gray regulates maternal aggression and maternal care in mice.

GABRA2 GABRA4

7.03e-05676220457185
Pubmed

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.

KIF5A HTT

7.03e-05676219525941
Pubmed

Chromosomal localization reveals three kinesin heavy chain genes in mouse.

PSMB7 KIF5A

7.03e-0567629782088
Pubmed

Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.

MTMR10 HTT

7.03e-05676232876667
Pubmed

Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice.

KIF3B APC

7.03e-05676231746486
Pubmed

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.

TRIM2 SEPTIN9 APC MED12 HSPA9

7.04e-0519576517110338
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

KIF3B ERC2 RAPGEF2 DNAH9

8.20e-051047649205841
Pubmed

Novel Cul3 binding proteins function to remodel E3 ligase complexes.

WDR35 WDR76 TRIM3

9.35e-054076325011449
Pubmed

Identification and typing of members of the protein-tyrosine phosphatase gene family expressed in mouse brain.

PTPRB PTPRS

9.83e-0577621454056
Pubmed

Developmental changes in the expression of gamma-aminobutyric acidA/benzodiazepine receptor subunit mRNAs in the murine inferior olivary complex.

GABRA2 GABRA4

9.83e-0577627560270
Pubmed

Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites.

ERC1 ERC2

9.83e-05776229398114
Pubmed

Polymorphisms and colorectal tumor risk.

NAT1 APC

9.83e-05776211487538
Pubmed

Rebuilding essential active zone functions within a synapse.

ERC1 ERC2

9.83e-05776235176221
Pubmed

Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism.

GABRA2 GABRA4

9.83e-05776216080114
Pubmed

Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice.

APC HTT

9.83e-05776224204315
Pubmed

RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis.

TCF7 APC

9.83e-05776218772112
Pubmed

Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells.

APC PLCE1

9.83e-05776227053111
Pubmed

Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.

ERC1 ERC2 KIF5A SLC4A4

1.02e-0411076427889896
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

NCOR1 RANBP2 UGDH DGKD SORBS1 HSPA9 PLCE1

1.09e-0449776723414517
Pubmed

gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties.

GABRA2 GABRA4

1.31e-0487628175718
Pubmed

Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women.

TCF7 APC

1.31e-04876220613673
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

RANBP2 SPTAN1 SORBS1 TRIM3 MPRIP

1.56e-0423176516452087
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

EHBP1 RANBP2 ERC1 SEPTIN9 GART APC MED12 HSPA9

1.58e-0470876839231216
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

RANBP2 EML5 APC RAPGEF2 CLSPN

1.59e-0423276525515538
Pubmed

Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.

PTPRB SPTAN1 ERC2 TRIM3 MPRIP

1.62e-0423376529518331
Pubmed

Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins.

ERC1 ERC2

1.68e-04976212923177
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RANBP2 KIF3B

1.68e-0497629733766
Pubmed

Physical mapping of the Tec and Gabrb1 loci reveals that the Wsh mutation on mouse chromosome 5 is associated with an inversion.

PGM2 GABRA2

1.68e-0497628589683
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

RANBP2 ERC1 POLA1 SEPTIN9 SPTAN1 UGDH APC MPRIP

1.84e-0472476836232890
Pubmed

Identification of 14-3-3epsilon substrates from embryonic murine brain.

ERC1 ERC2 KIF5A MPRIP

2.06e-0413276416944949
Pubmed

Functional modifications of acid-sensing ion channels by ligand-gated chloride channels.

GABRA2 GABRA4

2.10e-041076221789198
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

SPTAN1 ERC2 SORBS1 RAPGEF2 MPRIP

2.29e-0425176527507650
Pubmed

A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain.

PTPRB PTPRS

2.56e-04117627832766
Pubmed

The mouse gene encoding the GM2 activator protein (Gm2a): cDNA sequence, expression, and chromosome mapping.

PGM2 GABRA2

2.56e-04117627713516
Pubmed

The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors.

ELFN1 ERC2

2.56e-041176228262416
Pubmed

ER, Mitochondria, and ISR Regulation by mt-HSP70 and ATF5 upon Procollagen Misfolding in Osteoblasts.

HSPA9 SP7

2.56e-041176235988140
Pubmed

Review: Central non-glucocorticoid inhibitors of the hypothalamo-pituitary-adrenal axis.

GABRA2 GABRA4

2.56e-04117629924185
Pubmed

Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes.

TCF7 SP7

2.56e-041176215866163
Pubmed

Region and layer-specific expression of GABAA receptor isoforms and KCC2 in developing cortex.

GABRA2 GABRA4

2.56e-041176238894703
Pubmed

Quantitative trait locus for seizure susceptibility on mouse chromosome 5 confirmed with reciprocal congenic strains.

GABRA2 GABRA4

2.56e-041176217698926
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

KIF3B ERC1 SEPTIN9 ERC2 SORBS1 PLCE1

2.71e-0440776612693553
Cytoband4p12

GABRA2 GABRA4

5.04e-04207624p12
Cytoband10q23.33

SORBS1 ACSM6

6.69e-042376210q23.33
CytobandEnsembl 112 genes in cytogenetic band chr4p12

GABRA2 GABRA4

8.57e-0426762chr4p12
Cytoband15q13.3

FMN1 MTMR10

8.57e-042676215q13.3
Cytoband2p15

EHBP1 USP34

1.22e-03317622p15
Cytoband17p11.2

NCOR1 B9D1 MPRIP

2.38e-0315976317p11.2
CytobandEnsembl 112 genes in cytogenetic band chr2p15

EHBP1 USP34

2.45e-0344762chr2p15
CytobandEnsembl 112 genes in cytogenetic band chr17p11

NCOR1 B9D1 MPRIP

4.72e-03203763chr17p11
Cytoband5q31.1

TCF7 HSPA9

4.95e-03637625q31.1
CytobandEnsembl 112 genes in cytogenetic band chr12q13

NEUROD4 KIF5A STAT6 SP7

5.41e-03423764chr12q13
CytobandEnsembl 112 genes in cytogenetic band chr4p14

UGDH PGM2

5.58e-0367762chr4p14
Cytoband12q13.13

KIF5A SP7

5.58e-036776212q13.13
GeneFamilyFibronectin type III domain containing

LIFR PTPRB PTPRS ELFN1

1.15e-03160524555
GeneFamilyGamma-aminobutyric acid type A receptor subunits

GABRA2 GABRA4

1.34e-0319522563
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRB PTPRS

1.65e-0321522813
CoexpressionFAN_EMBRYONIC_CTX_ASTROCYTE_2

LIFR APC KCNN3 SLC4A4 SLC7A11 RIC3

5.81e-06154766M39034
CoexpressionGSE24574_BCL6_HIGH_VS_LOW_TFH_CD4_TCELL_UP

USP34 RANBP2 TRIM2 SEPTIN9 TENM1 RAPGEF2

2.50e-05199766M8324
CoexpressionGSE22886_IGM_MEMORY_BCELL_VS_BM_PLASMA_CELL_UP

TENM1 APC DGKD SLC4A4 SLC24A1 STAT6

2.57e-05200766M4456
CoexpressionSCHLOSSER_SERUM_RESPONSE_UP

KIF3B PTPRS SPTAN1 HTT STAT6

3.33e-05126765M16381
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

EHBP1 USP34 RANBP2 TRIM2 AUH ERC1 SEPTIN9 ARID5B APC RAPGEF2 PLCE1

3.49e-058567611M4500
CoexpressionCUI_TCF21_TARGETS_2_DN

LIFR NCOR1 PTPRB ADGRE3 ARID5B SORBS1 RAPGEF2 PGM2 MPRIP PLCE1 GABRA4

4.87e-058887611MM1018
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 TENM1 MYH15 UNC13C KIF5A SLC4A4 DNAH9 PLCE1

9.99e-101847682cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 TENM1 MYH15 UNC13C KIF5A SLC4A4 DNAH9 PLCE1

9.99e-10184768ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 TENM1 MYH15 UNC13C KIF5A SLC4A4 DNAH9 PLCE1

9.99e-101847682b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NDST3 MYO5B TENM1 DGKD SLC4A4 GALNT7 PLCE1

3.17e-081867676379609b7ace80683f5754b16aa77f11b43766ae
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like-AT2_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TCF7 EML5 FMN1 B9D1 HSPA9 ZFP82

4.36e-071687669e7b4b9b977e90e083f5164013e79df8bc2d492e
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NDST3 FREM2 ERC1 SLC4A4 GALNT7 GABRA2

6.75e-07181766aa233b652921848af2257cc3687a7a09c3acfb67
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B TENM1 DGKD SLC4A4 GALNT7 PLCE1

7.20e-07183766121791ef84e7ce377ed6f5b7953af8865e04958e
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B TENM1 DGKD SLC4A4 GALNT7 PLCE1

8.43e-071887668de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NDST3 MYO5B TENM1 DGKD SLC4A4 PLCE1

8.96e-071907668c9c230a509afaeee50644153974a5642b01a2b8
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NDST3 MYO5B TENM1 DGKD SLC4A4 PLCE1

9.53e-071927660003d7ef9a8e521e70ac33c63aad843d9b6215c2
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP34 RANBP2 PTPRB ERC1 ARID5B SORBS1

1.01e-06194766e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FREM2 MYO5B FMN1 DGKD SLC4A4 TMC5

1.17e-061997668587bd98de7767a575088afbea07a1feb4516b9b
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

APC KCNN3 MYH15 SORBS1 SLC7A11 GABRA2

1.21e-06200766d0812817ef99608994193787a62d39adeb2070ca
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

APC KCNN3 MYH15 SORBS1 SLC7A11 GABRA2

1.21e-06200766cd54ddf1919c98e84b7e4aba85b374fc8b407206
ToppCellBAL-Control-cDC_12|Control / Compartment, Disease Groups and Clusters

UGDH B9D1 KCNN3 CLSPN WDR76

6.69e-061547650121d08cc527aed9b3e11ff62bb9012916f5c56b
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NDST3 EHBP1 FREM2 SPSB1 UNC13C

7.57e-06158765f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NDST3 EHBP1 FREM2 SPSB1 UNC13C

7.57e-061587658c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCellnormal-na-Lymphocytic_B-B_plasma-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

SPSB1 B9D1 KCNN3 UNC13C SLC7A11

1.08e-05170765c5b87974dfddf9780051f7f5693eeeb0c606a3fe
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

FREM2 MYO5B SORBS1 TMC5 RIC3

1.18e-05173765b799c06a6a5754668e789f70c0c8bc1508568575
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CDK2AP2 DGKD CATSPERG SLC7A11 ZFP82

1.24e-0517576526bd957498e41a3f1ffa60d3effa27ca8c4ba631
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B TENM1 DGKD SLC4A4 PLCE1

1.39e-05179765d1365d48d1b017a7917f4f63a82ac4720c3d87df
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B TENM1 DGKD SLC4A4 PLCE1

1.58e-051847652ba98708dfd7f1b2a661578a334684094ff453ad
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NDST3 ERC1 UNC13C KIF5A GABRA2

1.67e-05186765a1ab273b01971d6a892912560d387685dd657179
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B TENM1 DGKD SLC4A4 PLCE1

1.71e-05187765d413fb4b1531b297af5012a392b88128510c2de8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NDST3 ERC1 UNC13C MTMR10 GABRA2

1.71e-05187765f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYO5B SEPTIN9 DGKD TMC5 MPRIP

1.75e-0518876543a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

GART ERC2 SLC4A4 TMC5 SLC7A11

1.75e-05188765ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellsevere_COVID-19-Plasmablast|severe_COVID-19 / disease group, cell group and cell class (v2)

B9D1 KCNN3 UNC13C CLSPN SLC7A11

1.80e-05189765953143b2c2e87a4d8ef033a5fbb155fe62e9c78e
ToppCellRA-14._Fibroblast_III|World / Chamber and Cluster_Paper

RANBP2 PTPRS SEPTIN9 SPSB1 UGDH

1.80e-05189765b6e12d24d2b0735730bdc625f8318c1c9c2a9b3b
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B TENM1 DGKD SLC4A4 PLCE1

1.80e-0518976578cf414b98bcb19deb934409acddaad1cd51b67f
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B TENM1 DGKD SLC4A4 PLCE1

1.85e-051907653f22c118d552345f731d4d49f0bcb5765d93de3b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B TENM1 DGKD SLC4A4 PLCE1

1.85e-05190765305fbef734c350cfbf786ca7ff6e07093aab56ea
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B TENM1 DGKD SLC4A4 PLCE1

1.85e-0519076539ab890104b4264c68a968f920f4ccd84f0bc681
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B TENM1 DGKD SLC4A4 PLCE1

1.85e-051907650acf1d5da68db449d8c9e70519a236ce825f9d11
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B TENM1 DGKD SLC4A4 PLCE1

1.85e-05190765e58e4b6fbeb4368f738adac67ec10879c0966f0f
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TCF7 FMN1 SPTAN1 ARID5B MPRIP

1.94e-051927657ab626a516b07d899175ff12f1c8257688324e4b
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TCF7 FMN1 SPTAN1 ARID5B RIC3

1.99e-05193765194b49c152e3e3f599068ec88a7f0af6427b743a
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B ELFN1 TENM1 DGKD PLCE1

1.99e-0519376553bcd50892c379b2a571751f6eb1062436339fe7
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1|TCGA-Endometrium / Sample_Type by Project: Shred V9

FREM2 POLA1 CLSPN WDR76 SLC7A11

1.99e-05193765c2673d86f7d7b849788036032a93a6d136a70040
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B TENM1 DGKD SLC4A4 PLCE1

1.99e-05193765c4b22b62f3cc7bf0ec0eba76e1504c236290bbc9
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B ELFN1 TENM1 DGKD PLCE1

2.04e-0519476502a9cc821c2b14aa7d0e55661a5fab66364474e1
ToppCellCaecum-T_cell-Tfh|T_cell / Region, Cell class and subclass

TCF7 ADGRE3 UNC13C DNAH9 RIC3

2.14e-05196765fe2ee5788028e6b671674f0cc50e2b6379f50976
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B ELFN1 TENM1 DGKD PLCE1

2.14e-051967657af6c5147ac859353504d19727dbe24f63a29dd4
ToppCelldistal-Endothelial-Bronchial_Vessel_2-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TRIM2 KCNN3 SLC7A11 PGM2 RIC3

2.20e-051977659fcfbfbe78e8fe90c76eb37a58ed9dc8ece652a1
ToppCellMS-CD4-naive_CD4|MS / Condition, Cell_class and T cell subcluster

TCF7 SEPTIN9 ARID5B RIC3 MPRIP

2.20e-05197765eb0d4849de4ca374bd9c1e138d4f2b9c19227b15
ToppCelldistal-3-Endothelial-Bronchial_Vessel_2|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TRIM2 KCNN3 SLC7A11 PGM2 RIC3

2.25e-05198765f701d06e3d7fd2192afae3698c5ec3c355e96da3
ToppCellIIH-CD4-naive_CD4|IIH / Condition, Cell_class and T cell subcluster

TCF7 SEPTIN9 ARID5B RIC3 MPRIP

2.25e-0519876585414b283bbcdbf3393ab1b4302ef0e21c7a8181
ToppCellBronchial-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FREM2 MYO5B FMN1 SLC4A4 TMC5

2.30e-051997655f7da3eab58ace6cddb3179a415cd839d5767958
ToppCellCaecum-(1)_T_cell-(16)_Tfh|Caecum / shred on region, Cell_type, and subtype

TCF7 ADGRE3 UNC13C DNAH9 RIC3

2.30e-05199765d07d77ae426dd1164d80d7031f14befa0369d3e5
ToppCellCaecum-T_cell-Tfh|Caecum / Region, Cell class and subclass

TCF7 ADGRE3 UNC13C DNAH9 RIC3

2.30e-05199765fb40f37d842f170ed101dfa3bffdb8f3b2c94f19
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-SULF1--L4-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

MYO5B TENM1 DGKD SLC4A4 PLCE1

2.36e-052007654a426ef88376d8bb2b9dc50aa06e7b9fc50ecc9c
ToppCellMacroglial-Astrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

KCNN3 SORBS1 SLC4A4 SLC7A11 GABRA2

2.36e-05200765941536b7c32f1e63c70535233b2ccce0cd7bf96e
ToppCellMacroglial-Astrocytes-SLC14A1---|Macroglial / cells hierarchy compared to all cells using T-Statistic

KCNN3 SORBS1 SLC4A4 SLC7A11 GABRA2

2.36e-05200765d6fcbf4f4bc1b89a9929d7b114c6b907b6979900
ToppCellMacroglial-Astrocytes-SLC14A1----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

KCNN3 SORBS1 SLC4A4 SLC7A11 GABRA2

2.36e-05200765f861509b54185d89931db64da1b9d81986cc7938
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)|Neuronal / cells hierarchy compared to all cells using T-Statistic

MYO5B TENM1 DGKD SLC4A4 PLCE1

2.36e-052007651276bfa911fddada4235e12e3081baa53164574b
ToppCellNeuronal-Inhibitory|Neuronal / cells hierarchy compared to all cells using T-Statistic

MYO5B ELFN1 TENM1 DGKD PLCE1

2.36e-052007659ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYO5B FMN1 DGKD TMC5 GALNT7

2.36e-05200765c450a15e21fa72d071ed6e3b9f22de557a0f3cea
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

APC KCNN3 SORBS1 SLC4A4 GABRA2

2.36e-0520076507d942803360e1a1e8e131d6e31c726dd0db1a0b
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-WFDC2--L2-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

MYO5B TENM1 DGKD SLC4A4 PLCE1

2.36e-05200765c65e6336725856c4b5f6aeba1cf86a23ec815d34
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_submucosal-gland|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TRIM2 MYO5B LACC1 TMC5 GALNT7

2.36e-0520076568b0f987c4fb8078675475f4f1e71302f832ef69
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Duct|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TRIM2 MYO5B LACC1 TMC5 GALNT7

2.36e-052007651b527bebbca1ef8c52449e40beb9358e37494e04
ToppCellMacroglial-Astrocytes-SLC14A1|Macroglial / cells hierarchy compared to all cells using T-Statistic

KCNN3 SORBS1 SLC4A4 SLC7A11 GABRA2

2.36e-0520076516f468217427921fa18c6d078ffa990eb019b257
ToppCellMacroglial-Astrocytes-SLC14A1--|Macroglial / cells hierarchy compared to all cells using T-Statistic

KCNN3 SORBS1 SLC4A4 SLC7A11 GABRA2

2.36e-052007650442894c39eec69850c090957a5dc7bcecd21e04
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-SULF1|Neuronal / cells hierarchy compared to all cells using T-Statistic

MYO5B TENM1 DGKD SLC4A4 PLCE1

2.36e-05200765fbeee1c16ac0a7fe28d90491c8b079f21ce80bdc
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-SULF1-|Neuronal / cells hierarchy compared to all cells using T-Statistic

MYO5B TENM1 DGKD SLC4A4 PLCE1

2.36e-05200765c6eda342ea0cb37d71d89dbb8d11e819e0745172
ToppCellMacroglial-Astrocytes-SLC14A1-|Macroglial / cells hierarchy compared to all cells using T-Statistic

KCNN3 SORBS1 SLC4A4 SLC7A11 GABRA2

2.36e-0520076501819446deeab9054f5cfe889d53bb49d137dbc0
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-WFDC2-|Neuronal / cells hierarchy compared to all cells using T-Statistic

MYO5B TENM1 DGKD SLC4A4 PLCE1

2.36e-05200765117a25b3b9cdbc2e198381350a8362bee25e82e7
ToppCellNeuronal-Inhibitory-iB|Neuronal / cells hierarchy compared to all cells using T-Statistic

MYO5B ELFN1 TENM1 DGKD PLCE1

2.36e-0520076545ddc5ef2caa87ada88327b63ba9b150a6bb3aa5
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-WFDC2|Neuronal / cells hierarchy compared to all cells using T-Statistic

MYO5B TENM1 DGKD SLC4A4 PLCE1

2.36e-05200765d459e51507bf26865e6e7e04411379ec82a3edf8
ToppCellURO-Lymphocyte-T_NK-CD8_Naive|URO / Disease, Lineage and Cell Type

TCF7 MYO5B SLC7A11 RIC3

8.17e-05134764142b7db0c2b686c8f2704ff7bcd9b44dfcb07403
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Alcam_(Alcam)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

POLA1 CATSPERG SLC7A11 HSPA9

1.02e-041427646a656d28c9f5dfb03a3a2d908cf2edbe0a5b1206
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

POLA1 CATSPERG SLC7A11 HSPA9

1.02e-04142764671ba8869db7a6dc69fd1caf0e561f15a312b170
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

POLA1 CATSPERG SLC7A11 HSPA9

1.02e-041427643557084150670fd2e2634fc674f228ab85181b59
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Alcam_(Alcam)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

POLA1 CATSPERG SLC7A11 HSPA9

1.02e-04142764a3d1f4b570b75402171e38c5a7c88e2896520c8f
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_bronchial_vessel-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NDST3 PTPRB ELFN1 GABRA2

1.08e-04144764748f4efc59f7afbce6c497524f36d852b8b1d637
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTPRB POLA1 CLSPN CATSPERG

1.14e-041467642d907e50206c4762a8baa741363bc7f0a04bd84e
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_bronchial_vessel|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NDST3 PTPRB ELFN1 GABRA2

1.14e-04146764df865558d1843f3857ebd1529cebc540d3554c59
ToppCellLPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ELFN1 ERC2 SLC4A4 PLCE1

1.51e-04157764bfec34182f052cf1c0d847ba53ea335d4d1190de
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCF7 UNC13C KIF5A STAT6

1.51e-04157764370f44047ef438b8f1124c2c2761c150c0d8c57f
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FREM2 MYO5B HPD RIC3

1.58e-04159764e6ff9d2bce62bf9ea173af80b688eeb40fa4ea4c
ToppCellHealthy/Control-CD8+_T_naive|Healthy/Control / Disease group and Cell class

TCF7 EML5 SORBS1 RIC3

1.62e-04160764e1386c21fcbbf57fa32d8bdfba3cb1887477ff73
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tregs|GI_large-bowel / Manually curated celltypes from each tissue

NAT1 TCF7 SPSB1 ARID5B

1.70e-041627649a5e65c45f73a6a685b8362aa2e6aea77181caa3
ToppCellControl|World / group, cell type (main and fine annotations)

FREM2 MYO5B SLC4A4 TMC5

1.95e-04168764a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCelldroplet-Lung-nan-18m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EML5 POLA1 KIF5A CLSPN

1.95e-0416876496f7411474edd673b8d3ee6b8a8bb185c246daaf
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH15 UNC13C TMC5 DNAH9

2.00e-0416976412bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LIFR PTPRB KCNN3 ACSM6

2.04e-041707641a568efcff9c39b3f709b55a05d24710450a2657
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LIFR PTPRB KCNN3 ACSM6

2.04e-0417076466d41d794790e621d72ac37af995510537103c9c
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FMN1 SPSB1 RAPGEF2 ZFP82

2.14e-04172764a9e13aa36087170dadca421ba9de588e5a1cf715
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FREM2 MYO5B UNC13C PLCE1

2.14e-041727649a256db817c1af1802203cc88a55d608fb328c63
ToppCellInfluenza_Severe-CD4+_Tcm|Influenza_Severe / Disease group and Cell class

TCF7 ARID5B MYH15 RIC3

2.14e-0417276447865a04968ca28c6ff125159d9a23e37c8b8af1
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTPRB POLA1 CLSPN WDR76

2.23e-04174764c988471207ba06195bc3e41056435e8c31c20bbe
ToppCellPND14-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EML5 LACC1 POLA1 CLSPN

2.23e-0417476409b091e24317c3f7bac043f04762a533e30793de
ToppCellfacs-Heart-LV-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13C SORBS1 TMC5 PLCE1

2.23e-04174764197686570cec6d96a92e77e6409325d3bfe6f991
ToppCellfacs-Heart-LV-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13C SORBS1 TMC5 PLCE1

2.23e-041747642eee7b5471672b439f95eba11494c2adf8cb7006
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

FMN1 SPSB1 RAPGEF2 ZFP82

2.28e-04175764f3a68aeb79c4935006e17a5ff3445a8ec0e33f5f
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NDST3 TENM1 UNC13C KIF5A

2.28e-0417576465571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LACC1 SLC4A4 SLC7A11 PGM2

2.33e-04176764ac3dc44755280e36c0947b6de3cd639dc17de8b6
ToppCelldroplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EML5 LACC1 FMN1 DARS2

2.38e-04177764f360f7099570d248531897b96e0de282e58f59e9
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-5|TCGA-Skin / Sample_Type by Project: Shred V9

NDST3 LIFR FREM2 PLCE1

2.43e-04178764ad5cd505ca1cef8ac29b2af7e2c3e01ebc140c14
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B TENM1 DGKD PLCE1

2.43e-041787646ad46b0720298bcb927fd53468bb4ea0c199ad35
DrugSecurinine [5610-40-2]; Up 200; 18.4uM; MCF7; HT_HG-U133A

EHBP1 USP34 SPTAN1 SLC4A4 WDR76 SLC24A1 SLC7A11

3.64e-061927673470_UP
DrugSulfapyridine [144-83-2]; Down 200; 16uM; MCF7; HT_HG-U133A

EHBP1 USP34 TCF7 GART APC WDR76 SLC7A11

4.03e-061957676799_DN
DrugDinoprost trometamol [38362-01-5]; Down 200; 8.4uM; HL60; HT_HG-U133A

TCF7 PTPRS NEUROD4 SEPTIN9 APC SLC7A11 GABRA2

4.03e-061957672446_DN
DrugMethimazole [60-56-0]; Up 200; 35uM; MCF7; HT_HG-U133A

ACTL7A LIFR GAS2L1 TCF7 SORBS1 KIF5A SLC24A1

4.17e-061967674372_UP
DrugTiaprofenic acid [33005-95-7]; Up 200; 15.4uM; MCF7; HT_HG-U133A

PTPRB ADGRE3 APC FGF6 SORBS1 SLC24A1 GABRA2

4.45e-061987674171_UP
DrugPhenethicillin potassium salt [132-93-4]; Down 200; 10uM; HL60; HT_HG-U133A

SEPTIN9 APC TMC5 SLC24A1 TRIM3 GABRA2 PLCE1

4.45e-061987672542_DN
DrugMidodrine hydrochloride [3092-17-9]; Down 200; 13.8uM; PC3; HT_HG-U133A

NCOR1 SPSB1 GART B9D1 DGKD TMC5 SLC7A11

4.60e-061997677156_DN
DrugHydroxytacrine maleate (R,S) [118909-22-1]; Down 200; 12.2uM; HL60; HT_HG-U133A

GAS2L1 TCF7 ERAP2 APC SLC4A4 GABRA2

4.72e-051947662430_DN
DrugFenbufen [36330-85-5]; Down 200; 15.8uM; MCF7; HT_HG-U133A

APC DGKD RAPGEF2 SLC4A4 TRIM3 GABRA2

4.86e-051957662308_DN
Drugcarmustine; Up 200; 100uM; MCF7; HT_HG-U133A

TCF7 PTPRS B9D1 RAPGEF2 SLC7A11 TRIM3

5.00e-051967666888_UP
Drug(-)-Eseroline fumarate salt [104015-29-4]; Down 200; 12uM; MCF7; HT_HG-U133A

NCOR1 SEPTIN9 SPTAN1 APC MED12 HTT

5.00e-051967667027_DN
DrugBenzthiazide [91-33-8]; Up 200; 9.2uM; PC3; HT_HG-U133A

PTPRB ADGRE3 SPTAN1 ERC2 KIF5A GABRA2

5.00e-051967666607_UP
DrugAlthiazide [5588-16-9]; Down 200; 10.4uM; PC3; HT_HG-U133A

ERAP2 SPTAN1 GART APC SORBS1 SLC4A4

5.00e-051967664491_DN
DrugSeneciphylline [480-81-9]; Down 200; 12uM; PC3; HT_HG-U133A

GAS2L1 TRIM2 APC B9D1 SLC4A4 GABRA2

5.00e-051967664238_DN
DrugDequalinium dichloride [522-51-0]; Up 200; 7.6uM; MCF7; HT_HG-U133A

NDST3 USP34 PTPRS SPTAN1 SLC24A1 SLC7A11

5.00e-051967662631_UP
Drugestradiol, USP; Down 200; 0.1uM; HL60; HT_HG-U133A

USP34 NEUROD4 SEPTIN9 ADGRE3 TMC5 STAT6

5.14e-051977662668_DN
Drug(1)-Nipecotic acid [498-95-3]; Up 200; 31uM; MCF7; HT_HG-U133A

TRIM2 FGF6 WDR76 SLC7A11 RIC3 PLCE1

5.14e-051977666500_UP
DrugMeprylcaine hydrochloride [956-03-6]; Up 200; 14.8uM; PC3; HT_HG-U133A

PTPRB SPTAN1 APC B9D1 SLC4A4 GABRA2

5.29e-051987665723_UP
DrugHexylcaine hydrochloride [532-76-3]; Up 200; 13.4uM; HL60; HT_HG-U133A

SEPTIN9 SPSB1 SPTAN1 FGF6 TRIM3 PLCE1

5.29e-051987662708_UP
Drug0173570-0000 [211245-44-2]; Up 200; 1uM; PC3; HT_HG-U133A

ERAP2 SPTAN1 APC SLC4A4 SLC7A11 RIC3

5.29e-051987667391_UP
DrugBromperidol [10457-90-6]; Up 200; 9.6uM; HL60; HG-U133A

EHBP1 USP34 GAS2L1 APC KIF5A HTT

5.29e-051987661723_UP
DrugAzathioprine [446-86-6]; Down 200; 14.4uM; MCF7; HT_HG-U133A

TCF7 TRIM2 NEUROD4 APC KIF5A TRIM3

5.29e-051987665262_DN
DrugEbselen [60940-34-3]; Down 200; 14.6uM; HL60; HT_HG-U133A

NEUROD4 SEPTIN9 APC B9D1 MYH15 SLC24A1

5.44e-051997662717_DN
DrugArticaine hydrochloride [23964-57-0]; Down 200; 12.4uM; HL60; HT_HG-U133A

GAS2L1 SEPTIN9 SPTAN1 MYH15 HTT GABRA4

5.44e-051997663138_DN
DrugMometasone furoate [83919-23-7]; Down 200; 7.6uM; MCF7; HT_HG-U133A

NCOR1 TCF7 KIF3B APC WDR76 MED12

5.44e-051997665541_DN
Drugsodium

ACTL7A NAT1 PTPRB GART CLDN16 KCNN3 SLC4A4 SLC24A1 SLC7A11 HSPA9 GABRA2 GABRA4

6.47e-059447612CID000000923
DrugLorazepam

GABRA2 GABRA4

1.09e-045762ctd:D008140
DrugAC1LD8HW

ACTL7A FMN1 PGM2 HSPA9

1.16e-0475764CID000644061
Drug3-isothujone

SAGE1 GABRA2 GABRA4

1.36e-0430763CID000011027
DrugMeprobamate

GABRA2 GABRA4

1.64e-046762DB00371
DrugFlunitrazepam

GABRA2 GABRA4

1.64e-046762DB01544
DrugMgCl2

ACTL7A NAT1 MYO5B POLA1 SPTAN1 CLDN16 DNAH9

1.80e-04354767CID000024584
Drug4-anisidine

NAT1 NEUROD4 SLC7A11

2.77e-0438763ctd:C013813
DrugC15H20O3

LIFR NCOR1 ERC1 FMN1 STAT6

3.01e-04175765CID000004692
DrugRo 15-4513

GABRA2 GABRA4

3.04e-048762ctd:C042957
Drugglutamate

ACTL7A AUH HPD ERC1 GART SLC4A4 SLC7A11 HTT GABRA2 PLCE1 GABRA4

3.35e-049627611CID000000611
DrugEthchlorvynol

GABRA2 GABRA4

3.90e-049762DB00189
Drug8-azidoadenine

POLA1 GART

3.90e-049762CID003036161
Druggeldanamycin; Up 200; 1uM; PC3; HT_HG-U133A

TRIM2 SPTAN1 SORBS1 SLC24A1 SLC7A11

3.98e-041867651228_UP
DrugMetoclopramide monohydrochloride [7232-21-5]; Down 200; 11.8uM; HL60; HT_HG-U133A

USP34 TCF7 KIF3B AUH GART

3.98e-041867652353_DN
DrugLY 294002; Up 200; 10uM; HL60; HT_HG-U133A

PTPRS SPTAN1 MYH15 RAPGEF2 HTT

3.98e-041867651177_UP
DrugICI 182,780; Up 200; 1uM; MCF7; HT_HG-U133A_EA

TCF7 TRIM2 SLC24A1 SLC7A11 STAT6

4.08e-041877651043_UP
DrugEthopropazine hydrochloride [1094-08-2]; Down 200; 11.4uM; MCF7; HT_HG-U133A

NCOR1 TCF7 SEPTIN9 B9D1 WDR76

4.39e-041907655296_DN
DrugClomipramine hydrochloride [17321-77-6]; Up 200; 11.4uM; MCF7; HT_HG-U133A

TRIM2 SLC4A4 SLC24A1 SLC7A11 STAT6

4.39e-041907656825_UP
DrugDiphenhydramine hydrochloride [147-24-0]; Down 200; 13.8uM; MCF7; HT_HG-U133A

EHBP1 TRIM2 APC RAPGEF2 WDR76

4.50e-041917656020_DN
DrugProtriptyline hydrochloride [1225-55-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A

TRIM2 B9D1 WDR76 SLC7A11 GABRA2

4.50e-041917656498_UP
Drugdaunorubicin HCl; Down 200; 1uM; MCF7; HT_HG-U133A

USP34 GART SLC4A4 SLC24A1 SLC7A11

4.50e-041917657507_DN
DrugEstropipate [7280-37-7]; Down 200; 9.2uM; MCF7; HT_HG-U133A

PTPRS APC RAPGEF2 TMC5 WDR76

4.61e-041927656808_DN
DrugTiapride hydrochloride [51012-33-0]; Down 200; 11uM; MCF7; HT_HG-U133A

USP34 PTPRS SPSB1 APC WDR76

4.61e-041927652292_DN
Drugcyclosporine A; Up 200; 1uM; MCF7; HG-U133A

SPSB1 B9D1 KIF5A SLC4A4 SLC7A11

4.61e-04192765602_UP
DrugResveratrol [501-36-0]; Up 200; 17.6uM; HL60; HG-U133A

GAS2L1 CDK2AP2 ARID5B RAPGEF2 HTT

4.72e-041937651715_UP
DrugPrednisolone [50-24-8]; Down 200; 11uM; PC3; HT_HG-U133A

USP34 TRIM2 GART SLC4A4 SLC7A11

4.72e-041937655101_DN
DrugCarcinine [56897-53-1]; Down 200; 22uM; PC3; HT_HG-U133A

GAS2L1 SEPTIN9 APC SLC24A1 SLC7A11

4.72e-041937654225_DN
DrugDiethylstilbestrol [56-53-1]; Down 200; 15uM; HL60; HT_HG-U133A

SEPTIN9 SPTAN1 APC FGF6 GABRA4

4.72e-041937652567_DN
DrugClotrimazole [23593-75-1]; Up 200; 11.6uM; MCF7; HT_HG-U133A

TRIM2 B9D1 SLC7A11 GABRA2 PLCE1

4.72e-041937656207_UP
DrugIsoxsuprine hydrochloride [579-56-6]; Down 200; 11.8uM; PC3; HT_HG-U133A

TRIM2 PTPRB ERAP2 SPSB1 MYH15

4.72e-041937654205_DN
DrugNSC350854

TCF7 POLA1 PSMB7 MYH15

4.72e-04108764CID000434448
DrugAzaguanine-8 [134-58-7]; Down 200; 26.2uM; MCF7; HT_HG-U133A

TRIM2 KIF3B SPTAN1 DGKD WDR76

4.83e-041947651670_DN
DrugSuramin sodium salt; Down 200; 10uM; PC3; HT_HG-U133A

NCOR1 TRIM2 SPTAN1 MYH15 SORBS1

4.83e-041947657529_DN
DrugCarbachol [51-83-2]; Down 200; 21.8uM; MCF7; HT_HG-U133A

NCOR1 TCF7 AUH SPTAN1 GART

4.83e-041947655342_DN
DrugLasalocid sodium salt [25999-20-6]; Down 200; 6.6uM; HL60; HT_HG-U133A

PTPRB SEPTIN9 MYH15 WDR76 GABRA4

4.83e-041947653021_DN
DrugFlunisolide [3385-03-3]; Down 200; 9.2uM; PC3; HT_HG-U133A

EHBP1 USP34 TRIM2 SLC4A4 SLC7A11

4.83e-041947653747_DN
DrugBenfluorex hydrochloride [23642-66-2]; Up 200; 10.4uM; MCF7; HT_HG-U133A

USP34 SPTAN1 APC SLC4A4 SLC7A11

4.83e-041947652621_UP
Drug(+)-Isoproterenol (+)-bitartrate salt [14638-70-1]; Down 200; 11uM; MCF7; HT_HG-U133A

NEUROD4 SPSB1 APC SLC7A11 TRIM3

4.83e-041947653384_DN
DrugFlucloxacillin sodium [1847-24-1]; Up 200; 8.4uM; MCF7; HT_HG-U133A

TRIM2 TENM1 B9D1 KIF5A SLC4A4

4.83e-041947656507_UP
DrugSecobarbital

GABRA2 GABRA4

4.86e-0410762DB00418
DrugChlordiazepoxide

GABRA2 GABRA4

4.86e-0410762DB00475
DrugMetharbital

GABRA2 GABRA4

4.86e-0410762DB00463
DrugPentobarbital

GABRA2 GABRA4

4.86e-0410762DB00312
DrugTalbutal

GABRA2 GABRA4

4.86e-0410762DB00306
DrugClobazam

GABRA2 GABRA4

4.86e-0410762DB00349
DrugButalbital

GABRA2 GABRA4

4.86e-0410762DB00241
DrugButabarbital

GABRA2 GABRA4

4.86e-0410762DB00237
DrugBromazepam

GABRA2 GABRA4

4.86e-0410762DB01558
DrugBarbituric acid derivative

GABRA2 GABRA4

4.86e-0410762DB01496
DrugBarbital

GABRA2 GABRA4

4.86e-0410762DB01483
DrugHexobarbital

GABRA2 GABRA4

4.86e-0410762DB01355
DrugAprobarbital

GABRA2 GABRA4

4.86e-0410762DB01352
DrugAmobarbital

GABRA2 GABRA4

4.86e-0410762DB01351
DrugHeptabarbital

GABRA2 GABRA4

4.86e-0410762DB01354
DrugButethal

GABRA2 GABRA4

4.86e-0410762DB01353
DrugAC1L1FKW

GABRA2 GABRA4

4.86e-0410762CID000003281
DrugMethylphenobarbital

GABRA2 GABRA4

4.86e-0410762DB00849
DrugOxazepam

GABRA2 GABRA4

4.86e-0410762DB00842
DrugPrimidone

GABRA2 GABRA4

4.86e-0410762DB00794
DrugMidazolam

GABRA2 GABRA4

4.86e-0410762DB00683
DrugFlurazepam

GABRA2 GABRA4

4.86e-0410762DB00690
DrugClonazepam

GABRA2 GABRA4

4.86e-0410762DB01068
Drugthymol

SAGE1 GABRA2 GABRA4

4.89e-0446763CID000006989
DrugRapamycin; Down 200; 0.1uM; HL60; HT_HG-U133A

GAS2L1 TCF7 NEUROD4 SEPTIN9 SLC7A11

4.94e-041957652681_DN
Drugestradiol, USP; Down 200; 0.01uM; HL60; HT_HG-U133A

GAS2L1 SEPTIN9 SPTAN1 FGF6 SLC4A4

4.94e-041957652701_DN
DrugGabapentin [60142-96-3]; Up 200; 23.4uM; MCF7; HT_HG-U133A

SEPTIN9 SPTAN1 SORBS1 SLC4A4 WDR76

4.94e-041957653472_UP
DrugFamprofazone [22881-35-2]; Up 200; 10.6uM; PC3; HT_HG-U133A

NEUROD4 SEPTIN9 TENM1 TRIM3 RIC3

4.94e-041957654309_UP
DrugBenperidol [2062-84-2]; Down 200; 10.4uM; HL60; HT_HG-U133A

TCF7 APC MYH15 SLC4A4 HTT

4.94e-041957652475_DN
DrugRapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA

SEPTIN9 GART RAPGEF2 SLC24A1 SLC7A11

4.94e-041957651045_UP
DrugSR-95639A [115767-94-7]; Up 200; 10uM; MCF7; HT_HG-U133A

APC WDR76 SLC24A1 SLC7A11 PLCE1

4.94e-041957653272_UP
DrugPiperacetazine [3819-00-9]; Up 200; 9.8uM; PC3; HT_HG-U133A

SEPTIN9 B9D1 MYH15 SORBS1 RAPGEF2

4.94e-041957655834_UP
DrugNiridazole [61-57-4]; Down 200; 18.6uM; HL60; HT_HG-U133A

NEUROD4 SEPTIN9 ARID5B APC HTT

5.06e-041967652440_DN
Drug2-propylpentanoic acid; Up 200; 200uM; HL60; HT_HG-U133A

GAS2L1 PTPRS SEPTIN9 RAPGEF2 GABRA2

5.06e-041967651155_UP
DrugPF-00875133-00 [351322-64-0]; Down 200; 10uM; PC3; HT_HG-U133A

SEPTIN9 APC FGF6 SLC4A4 TRIM3

5.06e-041967655928_DN
Diseaserenal tubular transport disease (is_implicated_in)

AUH CLDN16

6.37e-062752DOID:447 (is_implicated_in)
Diseasephosphatidylcholine 40:6 measurement

RAPGEF2 TMC5 DNAH9

1.05e-0517753EFO_0010389
Diseaseautosomal recessive limb-girdle muscular dystrophy (implicated_via_orthology)

TRIM2 TRIM3

1.91e-053752DOID:0110274 (implicated_via_orthology)
Diseaseautosomal recessive limb-girdle muscular dystrophy type 2H (implicated_via_orthology)

TRIM2 TRIM3

1.91e-053752DOID:0110282 (implicated_via_orthology)
Diseaseadenocarcinoma (is_implicated_in)

NAT1 APC

3.81e-054752DOID:299 (is_implicated_in)
Diseaseendoplasmic reticulum aminopeptidase 1 measurement

ERAP2 ERC2

1.33e-047752EFO_0008119
DiseaseSchizophrenia

NDST3 LIFR EML5 MYO5B APC KCNN3 MED12 HSPA9 GABRA4

3.97e-04883759C0036341
DiseaseMalignant neoplasm of liver

NCOR1 MYO5B UGDH APC

4.79e-04142754C0345904
DiseaseLiver neoplasms

NCOR1 MYO5B UGDH APC

4.79e-04142754C0023903
Diseaseanemia (implicated_via_orthology)

APC SLC4A4

6.55e-0415752DOID:2355 (implicated_via_orthology)
Diseasetriacylglycerol 46:0 measurement

FMN1 ERC2

6.55e-0415752EFO_0010400
Diseaserespiratory symptom measurement, COVID-19

FREM2 SEPTIN9 UGDH

8.98e-0474753EFO_0007939, MONDO_0100096
DiseaseProstatic Neoplasms

EHBP1 NAT1 LIFR NCOR1 CDK2AP2 APC MED12

9.72e-04616757C0033578
DiseaseMalignant neoplasm of prostate

EHBP1 NAT1 LIFR NCOR1 CDK2AP2 APC MED12

9.72e-04616757C0376358
Diseaseurate measurement, bone density

NAT1 ERC1 ADGRE3 ARID5B DGKD ACSM6 DNAH9

1.00e-03619757EFO_0003923, EFO_0004531
Diseasecardiovascular disease

USP34 ERAP2 SEPTIN9 ARID5B SORBS1 PLCE1

1.09e-03457756EFO_0000319
Diseasevital capacity

EHBP1 USP34 NCOR1 ERC1 SEPTIN9 SPSB1 ARID5B ERC2 ZFP82 PLCE1

1.12e-0312367510EFO_0004312
Diseasealcohol consumption measurement

NDST3 EHBP1 PTPRB ARID5B GALNT7 WDR76 HTT STAT6 GABRA2 GABRA4

1.16e-0312427510EFO_0007878
Diseasemuscular dystrophy (implicated_via_orthology)

TRIM2 TRIM3

1.30e-0321752DOID:9884 (implicated_via_orthology)
Diseasemigraine disorder, Headache

FGF6 STAT6 PLCE1

1.39e-0386753HP_0002315, MONDO_0005277
DiseaseSplenomegaly

APC KCNN3

1.42e-0322752C0038002
DiseaseMalignant neoplasm of breast

EHBP1 NCOR1 SPTAN1 TENM1 SORBS1 CLSPN DNAH9 MED12 GABRA4

1.58e-031074759C0006142
Diseasealcohol use disorder measurement, alcohol consumption measurement

EHBP1 GALNT7 GABRA4

1.96e-0397753EFO_0007878, EFO_0009458
DiseaseColorectal Carcinoma

NDST3 LIFR PTPRS TENM1 APC KDF1 RIC3

2.05e-03702757C0009402
Diseasemosquito bite reaction size measurement

USP34 UNC13C SLC4A4 STAT6

2.11e-03212754EFO_0008378
Diseaseindole-3-propionate measurement

NAT1 UNC13C

2.15e-0327752EFO_0010501
Diseaseazoospermia (implicated_via_orthology)

NDST3 PTPRS

2.15e-0327752DOID:14227 (implicated_via_orthology)
Diseaseeye morphology measurement

NAT1 SEPTIN9 ERC2 MPRIP

2.34e-03218754EFO_0007858

Protein segments in the cluster

PeptideGeneStartEntry
TKGTTGAPKMVEYSQ

ACSM6

226

Q6P461
TTMLGGYVYSTPAKK

NAT1

86

P18440
GTESYTSTAMAPKGI

CATSPERG

466

Q6ZRH7
DTPKASKGSYMEVRT

ELFN1

516

P0C7U0
YGRVKRGSKVSPIMT

FGF6

186

P10767
GVSMAKSYSAPRTET

CLDN16

211

Q9Y5I7
GKSKGRKYPPMDSDS

NDST3

821

O95803
SSETSKAPKSGFEGM

RANBP2

1706

P49792
MYGSARSVGKVEPSS

ERC1

1

Q8IUD2
TVRYFGMKPKSGEKE

FMN1

1331

Q68DA7
STDKLPYVTMGSGSL

PSMB7

161

Q99436
VPGRKYMATVTSISG

PTPRB

526

P23467
KSPDSATVSGYDIMK

MPRIP

976

Q6WCQ1
RGEMKSYSPTQVREK

SLC24A1

171

O60721
TKKSYSSTLRGMPSA

MTMR10

576

Q9NXD2
PAPKRGYSSEMKTED

AUH

61

Q13825
TSKAKESAEPMSGYP

FREM2

2386

Q5SZK8
GKETIKSSTGEYTVM

GABRA2

226

P47869
SSCKYSGGVMKPLSR

KCNN3

176

Q9UGI6
TMRTSGTEPKIKYYA

PGM2

556

Q96G03
IMGRKEPDSYDGITT

LACC1

256

Q8IV20
KRSQPATKTEDYGMG

MED12

1791

Q93074
TGYMPRKASVGSAST

GABRA4

461

P48169
ASTTYPKGTMTLGRA

ERC2

71

O15083
GKTTAEDGKCYTAMP

RIC3

121

Q7Z5B4
AYKKMASEREGSGSS

HSPA9

651

P38646
GKETGTPISMKDVYE

POLA1

401

P09884
AYTMKGDGARSKPKV

PTPRS

811

Q13332
KEIRPTYAGSKSAME

CDK2AP2

86

O75956
MYTGKEKVSPGRTSD

HTT

2926

P42858
PMIKVSEGKYRVGDS

GAS2L1

226

Q99501
KTKTEPYRSPAMAGG

GALNT7

376

Q86SF2
ARSGVKMSELPSYGE

EHBP1

876

Q8NDI1
SSKSMDRVYGKPRTT

DGKD

1016

Q16760
TLQSEEDSRYMKPGK

ERAP2

121

Q6P179
EGTKSYVPYRDSKMT

KIF5A

271

Q12840
LFYRMPGGKEVTSTE

EML5

476

Q05BV3
SGEPTKTSLGMYSKE

DNAH9

1646

Q9NYC9
KDMRKLGYDTGPSDT

B9D1

176

Q9UPM9
DGGVGPEKSMYVVTK

LIFR

816

P42702
MTTYSDKGAKPERGR

HPD

1

P32754
ATYGTDKPDTRFGMK

DARS2

326

Q6PI48
EKPVGGLSSSDTMDY

PLCE1

2286

Q9P212
YMSTDSAIPFGEKKR

MYH15

636

Q9Y2K3
KPYDGITTIKEMGRS

NCOR1

1336

O75376
SMRQTSSGYGREKPS

PPP1R32

106

Q7Z5V6
MKKSYSGGTRTSSGR

SEPTIN9

1

Q9UHD8
MDTTYSPIGGKVSDK

TENM1

371

Q9UKZ4
LKSTMGSSFSYPDVK

KDF1

151

Q8NAX2
STTVGKPYMETAKTG

ACTL7A

96

Q9Y615
YTLSSKMGPDSKPSE

ADGRE3

626

Q9BY15
TMSGPKKYPESLSRS

ARID5B

961

Q14865
SVSSSDGYGKRGQMK

APC

966

P25054
SSSKMGYFPTEEKSE

CLSPN

731

Q9HAW4
TYRTFLSSPMEVGKK

RAPGEF2

301

Q9Y4G8
MVRKPVVSTISKGGY

SLC7A11

1

Q9UPY5
FISVNTPTKTYGMGK

UGDH

86

O60701
RKEKGIPSSQTYESM

UNC13C

416

Q8NB66
AGGIPSMSTKDLYAT

SAGE1

516

Q9NXZ1
TGGIKTVDMRDPTYR

SPSB1

6

Q96BD6
KPYSVGSDLSASKTM

SP7

46

Q8TDD2
GKTYTMEGIRGDPEK

KIF3B

101

O15066
KDGRGYVPATIKMTV

STAT6

636

P42226
MREKEPIVGSTDYGK

SPTAN1

906

Q13813
VPRSKSEMSYIDGEK

SORBS1

476

Q9BX66
TVVMASKGYPGDYTK

GART

336

P22102
GLKAPECTSGMYKET

TCF7

106

P36402
GYFSSVKMPSEKVSS

ZFP82

136

Q8N141
PGTSYEKLTSSSMGK

WDR76

436

Q9H967
SLPSSDKRKNMYSGG

SLC4A4

396

Q9Y6R1
DYGSSETPKMTRGVL

TMC5

251

Q6UXY8
TPYTEDFLMGKSERK

USP34

2116

Q70CQ2
SMYSTGKRKENPIED

TRIM2

456

Q9C040
PSGSMDGVLDYSKTI

WDR35

486

Q9P2L0
MYSTGGKRKDNPIED

TRIM3

456

O75382
SGVKPTGYRKRSSSM

MYO5B

1631

Q9ULV0
VKEEESRPGTYGMLS

NEUROD4

31

Q9HD90