Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cholesterol dehydrogenase activity	HSD3B1 HSD3B2	1.25e-05	2	71	2	GO:0102294
GeneOntologyMolecularFunction	nitric-oxide synthase activity	NOS1 NOS3	3.73e-05	3	71	2	GO:0004517
GeneOntologyMolecularFunction	hedgehog receptor activity	PTCH2 PTCH1	3.73e-05	3	71	2	GO:0008158
GeneOntologyMolecularFunction	beta-catenin binding	GRIP1 AJAP1 MED12L CDH23 NOS3	6.84e-05	120	71	5	GO:0008013
GeneOntologyMolecularFunction	tetrahydrobiopterin binding	NOS1 NOS3	7.44e-05	4	71	2	GO:0034617
GeneOntologyMolecularFunction	smoothened binding	PTCH2 PTCH1	7.44e-05	4	71	2	GO:0005119
GeneOntologyMolecularFunction	hedgehog family protein binding	PTCH2 PTCH1	7.44e-05	4	71	2	GO:0097108
GeneOntologyMolecularFunction	3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity	HSD3B1 HSD3B2	1.85e-04	6	71	2	GO:0003854
GeneOntologyMolecularFunction	steroid delta-isomerase activity	HSD3B1 HSD3B2	2.59e-04	7	71	2	GO:0004769
GeneOntologyMolecularFunction	IgG receptor activity	FCGR2C FCGR2B	2.59e-04	7	71	2	GO:0019770
GeneOntologyMolecularFunction	5alpha-androstane-3beta,17beta-diol dehydrogenase activity	HSD3B1 HSD3B2	3.44e-04	8	71	2	GO:0047024
GeneOntologyMolecularFunction	3-keto sterol reductase activity	HSD3B1 HSD3B2	3.44e-04	8	71	2	GO:0000253
GeneOntologyMolecularFunction	arginine binding	NOS1 NOS3	4.42e-04	9	71	2	GO:0034618
GeneOntologyMolecularFunction	IgG binding	FCGR2C FCGR2B	6.72e-04	11	71	2	GO:0019864
GeneOntologyMolecularFunction	cadmium ion binding	NOS1 NOS3	8.04e-04	12	71	2	GO:0046870
GeneOntologyMolecularFunction	immunoglobulin receptor activity	FCGR2C FCGR2B	1.10e-03	14	71	2	GO:0019763
GeneOntologyMolecularFunction	monocarboxylate:sodium symporter activity	SLC5A6 SLC10A6	1.27e-03	15	71	2	GO:0140161
GeneOntologyMolecularFunction	calcium ion binding	HSPG2 DUOX1 STAB2 CELSR3 UMODL1 PKD2 CDH23 PCDHA10 CDH16	1.30e-03	749	71	9	GO:0005509
GeneOntologyMolecularFunction	NADP binding	DUOX1 NOS1 NOS3	1.40e-03	62	71	3	GO:0050661
GeneOntologyMolecularFunction	FMN binding	NOS1 NOS3	1.45e-03	16	71	2	GO:0010181
GeneOntologyMolecularFunction	adenylate cyclase activity	GUCY1B1 ADCY3	1.84e-03	18	71	2	GO:0004016
GeneOntologyMolecularFunction	symporter activity	SLC5A6 SLC10A6 MFSD2B SLC45A2	2.01e-03	150	71	4	GO:0015293
GeneOntologyMolecularFunction	intramolecular oxidoreductase activity, transposing C=C bonds	HSD3B1 HSD3B2	2.05e-03	19	71	2	GO:0016863
GeneOntologyMolecularFunction	secondary active monocarboxylate transmembrane transporter activity	SLC5A6 SLC10A6	2.05e-03	19	71	2	GO:0015355
GeneOntologyMolecularFunction	heme binding	DUOX1 GUCY1B1 NOS1 NOS3	2.21e-03	154	71	4	GO:0020037
GeneOntologyMolecularFunction	RNA helicase activity	TDRD9 DDX20 DHX30	2.71e-03	78	71	3	GO:0003724
GeneOntologyMolecularFunction	tetrapyrrole binding	DUOX1 GUCY1B1 NOS1 NOS3	2.78e-03	164	71	4	GO:0046906
GeneOntologyMolecularFunction	ATP-dependent activity, acting on RNA	TDRD9 DDX20 DHX30	2.91e-03	80	71	3	GO:0008186
GeneOntologyMolecularFunction	phospholipid scramblase activity	ANO9 ATG9A	3.01e-03	23	71	2	GO:0017128
GeneOntologyMolecularFunction	cyclase activity	GUCY1B1 ADCY3	3.27e-03	24	71	2	GO:0009975
GeneOntologyMolecularFunction	phosphorus-oxygen lyase activity	GUCY1B1 ADCY3	3.55e-03	25	71	2	GO:0016849
GeneOntologyMolecularFunction	monocarboxylic acid transmembrane transporter activity	SLC5A6 SLC10A6 SLC26A6	4.06e-03	90	71	3	GO:0008028
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC5A6 SLC10A6 MFSD2B SLC45A2 SLC26A6	4.06e-03	296	71	5	GO:0015291
GeneOntologyMolecularFunction	mRNA 3'-UTR AU-rich region binding	TIA1 TIAL1	4.76e-03	29	71	2	GO:0035925
GeneOntologyMolecularFunction	hyaluronic acid binding	STAB2 HAPLN4	4.76e-03	29	71	2	GO:0005540
GeneOntologyMolecularFunction	lipid transporter activity	ANO9 SLC10A6 MFSD2B ATG9A	5.24e-03	196	71	4	GO:0005319
GeneOntologyMolecularFunction	MHC class I protein binding	PILRA HLA-G	5.77e-03	32	71	2	GO:0042288
GeneOntologyBiologicalProcess	negative regulation of iron ion transport	HSD3B1 HSD3B2 NOS1	7.43e-07	6	70	3	GO:0034757
GeneOntologyBiologicalProcess	regulation of iron ion transport	HSD3B1 HSD3B2 NOS1	8.06e-06	12	70	3	GO:0034756
GeneOntologyBiologicalProcess	trans-synaptic signaling by soluble gas	GUCY1B1 NOS1	3.40e-05	3	70	2	GO:0099543
GeneOntologyBiologicalProcess	trans-synaptic signaling by nitric oxide	GUCY1B1 NOS1	3.40e-05	3	70	2	GO:0099548
GeneOntologyBiologicalProcess	synaptic signaling by nitric oxide	GUCY1B1 NOS1	1.13e-04	5	70	2	GO:0099163
GeneOntologyBiologicalProcess	positive regulation of guanylate cyclase activity	NOS1 NOS3	1.69e-04	6	70	2	GO:0031284
GeneOntologyBiologicalProcess	epidermal cell fate specification	PTCH2 PTCH1	1.69e-04	6	70	2	GO:0009957
GeneOntologyBiologicalProcess	negative regulation of dendritic cell differentiation	FCGR2B HLA-G	1.69e-04	6	70	2	GO:2001199
GeneOntologyCellularComponent	basal part of cell	CADM1 AJAP1 PRCP SLC5A6 PKD2 SLC26A6 CDH16	3.21e-04	378	72	7	GO:0045178
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	STAB2 LAMTOR4 PRCP VPS13C PKD2 HLA-G DISP3 SLC45A2 ATG9A PTCH1 NOS3 SLC26A6 PARM1	4.69e-04	1307	72	13	GO:0030659
GeneOntologyCellularComponent	vesicle membrane	STAB2 LAMTOR4 PRCP VPS13C PKD2 HLA-G DISP3 SLC45A2 ATG9A PTCH1 NOS3 SLC26A6 PARM1	5.34e-04	1325	72	13	GO:0012506
GeneOntologyCellularComponent	smooth endoplasmic reticulum membrane	HSD3B1 HSD3B2	7.55e-04	12	72	2	GO:0030868
GeneOntologyCellularComponent	basolateral plasma membrane	CADM1 AJAP1 SLC5A6 PKD2 SLC26A6 CDH16	8.21e-04	320	72	6	GO:0016323
GeneOntologyCellularComponent	apical part of cell	DUOX1 AJAP1 SLC39A3 SLC5A6 CDH23 PTCH1 NOS3 SLC26A6	9.60e-04	592	72	8	GO:0045177
HumanPheno	Odontogenic neoplasm	HSPG2 PTCH2 PTCH1	7.31e-06	8	27	3	HP:0100612
HumanPheno	Odontogenic keratocysts of the jaw	PTCH2 PTCH1	8.09e-05	3	27	2	HP:0010603
HumanPheno	Cardiac fibroma	PTCH2 PTCH1	8.09e-05	3	27	2	HP:0010617
HumanPheno	Ovarian fibroma	PTCH2 PTCH1	8.09e-05	3	27	2	HP:0010618
HumanPheno	Bridged sella turcica	PTCH2 PTCH1	8.09e-05	3	27	2	HP:0005449
HumanPheno	Bifid ribs	HSPG2 PTCH2 PTCH1	8.60e-05	17	27	3	HP:0000892
HumanPheno	Prominent fingertip pads	DEAF1 MED12L ZNF407 DHX30	8.78e-05	46	27	4	HP:0001212
HumanPheno	Prominent digit pad	DEAF1 MED12L ZNF407 DHX30	1.04e-04	48	27	4	HP:0011298
HumanPheno	Plantar pits	PTCH2 PTCH1	1.61e-04	4	27	2	HP:0010612
MousePheno	abnormal cerebral blood flow rate	NOS1 NOS3	1.52e-05	2	55	2	MP:0031182
MousePheno	abnormal brain blood flow rate	NOS1 NOS3	4.55e-05	3	55	2	MP:0031179
MousePheno	increased tear production	HSD3B1 HSD3B2	4.55e-05	3	55	2	MP:0020219
MousePheno	decreased coronary flow rate	NOS1 NOS3	9.07e-05	4	55	2	MP:0003023
Domain	Ptc/Disp	PTCH2 DISP3 PTCH1	3.82e-06	9	68	3	IPR003392
Domain	Patched	PTCH2 DISP3 PTCH1	3.82e-06	9	68	3	PF02460
Domain	SSD	PTCH2 DISP3 PTCH1	1.29e-05	13	68	3	IPR000731
Domain	SSD	PTCH2 DISP3 PTCH1	1.29e-05	13	68	3	PS50156
Domain	TM_rcpt_patched	PTCH2 PTCH1	1.31e-05	2	68	2	IPR004766
Domain	-	NOS1 NOS3	3.91e-05	3	68	2	3.90.340.10
Domain	NO_synthase	NOS1 NOS3	3.91e-05	3	68	2	PF02898
Domain	NOS_N	NOS1 NOS3	3.91e-05	3	68	2	IPR004030
Domain	NOS	NOS1 NOS3	3.91e-05	3	68	2	PS60001
Domain	NOS_euk	NOS1 NOS3	3.91e-05	3	68	2	IPR012144
Domain	Fd_Rdtase_FAD-bd	DUOX1 NOS1 NOS3	4.29e-05	19	68	3	IPR017927
Domain	FAD_FR	DUOX1 NOS1 NOS3	4.29e-05	19	68	3	PS51384
Domain	Riboflavin_synthase-like_b-brl	DUOX1 NOS1 NOS3	4.29e-05	19	68	3	IPR017938
Domain	EGF_LAM_2	HSPG2 STAB2 CELSR3	1.75e-04	30	68	3	PS50027
Domain	EGF_LAM_1	HSPG2 STAB2 CELSR3	1.75e-04	30	68	3	PS01248
Domain	FAD_binding_1	NOS1 NOS3	1.94e-04	6	68	2	PF00667
Domain	FAD-binding_1	NOS1 NOS3	1.94e-04	6	68	2	IPR003097
Domain	-	NOS1 NOS3	1.94e-04	6	68	2	1.20.990.10
Domain	NADPH_Cyt_P450_Rdtase_dom3	NOS1 NOS3	1.94e-04	6	68	2	IPR023173
Domain	3Beta_OHSteriod_DH/Estase	HSD3B1 HSD3B2	1.94e-04	6	68	2	IPR002225
Domain	3Beta_HSD	HSD3B1 HSD3B2	1.94e-04	6	68	2	PF01073
Domain	EGF_Lam	HSPG2 STAB2 CELSR3	2.78e-04	35	68	3	SM00180
Domain	Laminin_EGF	HSPG2 STAB2 CELSR3	3.55e-04	38	68	3	IPR002049
Domain	FLAVODOXIN_LIKE	NOS1 NOS3	3.61e-04	8	68	2	PS50902
Domain	Flavodoxin/NO_synth	NOS1 NOS3	3.61e-04	8	68	2	IPR008254
Domain	Flavdoxin-like	NOS1 NOS3	3.61e-04	8	68	2	IPR001094
Domain	Flavodoxin_1	NOS1 NOS3	3.61e-04	8	68	2	PF00258
Domain	Flavoprotein-like_dom	NOS1 NOS3	5.77e-04	10	68	2	IPR029039
Domain	Flavoprot_Pyr_Nucl_cyt_Rdtase	NOS1 NOS3	5.77e-04	10	68	2	IPR001709
Domain	-	NOS1 NOS3	5.77e-04	10	68	2	3.40.50.360
Domain	Cadherin_CS	CELSR3 CDH23 PCDHA10 CDH16	6.71e-04	109	68	4	IPR020894
Domain	CADHERIN_1	CELSR3 CDH23 PCDHA10 CDH16	7.68e-04	113	68	4	PS00232
Domain	Cadherin	CELSR3 CDH23 PCDHA10 CDH16	7.68e-04	113	68	4	PF00028
Domain	CADHERIN_2	CELSR3 CDH23 PCDHA10 CDH16	7.94e-04	114	68	4	PS50268
Domain	-	CELSR3 CDH23 PCDHA10 CDH16	7.94e-04	114	68	4	2.60.40.60
Domain	CA	CELSR3 CDH23 PCDHA10 CDH16	8.20e-04	115	68	4	SM00112
Domain	OxRdtase_FAD/NAD-bd	NOS1 NOS3	8.42e-04	12	68	2	IPR001433
Domain	NAD_binding_1	NOS1 NOS3	8.42e-04	12	68	2	PF00175
Domain	Cadherin-like	CELSR3 CDH23 PCDHA10 CDH16	8.47e-04	116	68	4	IPR015919
Domain	Cadherin	CELSR3 CDH23 PCDHA10 CDH16	9.03e-04	118	68	4	IPR002126
Domain	LINK	STAB2 HAPLN4	9.93e-04	13	68	2	SM00445
Domain	Link_dom	STAB2 HAPLN4	9.93e-04	13	68	2	IPR000538
Domain	Xlink	STAB2 HAPLN4	9.93e-04	13	68	2	PF00193
Domain	LINK_1	STAB2 HAPLN4	9.93e-04	13	68	2	PS01241
Domain	LINK_2	STAB2 HAPLN4	9.93e-04	13	68	2	PS50963
Domain	EGF_CA	HSPG2 STAB2 CELSR3 UMODL1	1.02e-03	122	68	4	SM00179
Domain	EGF-like_Ca-bd_dom	HSPG2 STAB2 CELSR3 UMODL1	1.09e-03	124	68	4	IPR001881
Domain	A/G_cyclase_CS	GUCY1B1 ADCY3	1.71e-03	17	68	2	IPR018297
Domain	PDZ	GRIP1 HTRA2 MAGI3 NOS1	1.74e-03	141	68	4	PF00595
Domain	HA2	TDRD9 DHX30	1.92e-03	18	68	2	SM00847
Domain	HA2	TDRD9 DHX30	1.92e-03	18	68	2	PF04408
Domain	Nucleotide_cyclase	GUCY1B1 ADCY3	1.92e-03	18	68	2	IPR029787
Domain	Helicase-assoc_dom	TDRD9 DHX30	1.92e-03	18	68	2	IPR007502
Domain	-	GUCY1B1 ADCY3	1.92e-03	18	68	2	3.30.70.1230
Domain	PDZ	GRIP1 HTRA2 MAGI3 NOS1	2.08e-03	148	68	4	SM00228
Domain	GUANYLATE_CYCLASE_1	GUCY1B1 ADCY3	2.15e-03	19	68	2	PS00452
Domain	Guanylate_cyc	GUCY1B1 ADCY3	2.15e-03	19	68	2	PF00211
Domain	GUANYLATE_CYCLASE_2	GUCY1B1 ADCY3	2.15e-03	19	68	2	PS50125
Domain	A/G_cyclase	GUCY1B1 ADCY3	2.15e-03	19	68	2	IPR001054
Domain	CYCc	GUCY1B1 ADCY3	2.15e-03	19	68	2	SM00044
Domain	-	GRIP1 HTRA2 MAGI3 NOS1	2.18e-03	150	68	4	2.30.42.10
Domain	PDZ	GRIP1 HTRA2 MAGI3 NOS1	2.24e-03	151	68	4	PS50106
Domain	PDZ	GRIP1 HTRA2 MAGI3 NOS1	2.29e-03	152	68	4	IPR001478
Domain	DEAD/DEAH_box_helicase_dom	TDRD9 DDX20 DHX30	2.39e-03	73	68	3	IPR011545
Domain	DEAD	TDRD9 DDX20 DHX30	2.39e-03	73	68	3	PF00270
Domain	SEA	HSPG2 UMODL1	2.88e-03	22	68	2	PF01390
Domain	RRM_dom_euk	TIA1 TIAL1	3.15e-03	23	68	2	IPR003954
Domain	SEA	HSPG2 UMODL1	3.15e-03	23	68	2	PS50024
Domain	SEA_dom	HSPG2 UMODL1	3.15e-03	23	68	2	IPR000082
Domain	RRM_1	TIA1 TIAL1	3.15e-03	23	68	2	SM00361
Pathway	REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE	GUCY1B1 NOS1 NOS3	6.54e-05	22	51	3	M915
Pathway	WP_SILDENAFIL_TREATMENT	GUCY1B1 NOS1 NOS3	7.51e-05	23	51	3	M46455
Pathway	REACTOME_MINERALOCORTICOID_BIOSYNTHESIS	HSD3B1 HSD3B2	1.91e-04	6	51	2	M27075
Pathway	REACTOME_GLI_PROTEINS_BIND_PROMOTERS_OF_HH_RESPONSIVE_GENES_TO_PROMOTE_TRANSCRIPTION	PTCH2 PTCH1	2.66e-04	7	51	2	M27501
Pathway	WP_EFFECTS_OF_NITRIC_OXIDE	NOS1 NOS3	3.54e-04	8	51	2	M39677
Pathway	WP_PEROXIREDOXIN_2_INDUCED_OVARIAN_FAILURE	HSD3B1 HSD3B2	3.54e-04	8	51	2	MM15965
Pathway	WP_STEROID_BIOSYNTHESIS	HSD3B1 HSD3B2	4.55e-04	9	51	2	MM15903
Pathway	WP_STEROID_HORMONE_PRECURSOR_BIOSYNTHESIS	HSD3B1 HSD3B2	4.55e-04	9	51	2	M46465
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY_PTCH_CORECEPTOR	PTCH2 PTCH1	4.55e-04	9	51	2	M47893
Pathway	WP_STEROID_BIOSYNTHESIS	HSD3B1 HSD3B2	5.67e-04	10	51	2	M39538
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	HSD3B1 HSD3B2	5.67e-04	10	51	2	M27076
Pathway	WP_NOCGMPPKG_MEDIATED_NEUROPROTECTION	GUCY1B1 NOS1 NOS3	6.47e-04	47	51	3	M39531
Pathway	KEGG_MEDICUS_REFERENCE_TESTOSTERONE_BIOSYNTHESIS	HSD3B1 HSD3B2	6.91e-04	11	51	2	M47895
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	HSD3B1 HSD3B2	6.91e-04	11	51	2	MM14750
Pathway	REACTOME_ANDROGEN_BIOSYNTHESIS	HSD3B1 HSD3B2	6.91e-04	11	51	2	M504
Pathway	REACTOME_MINERALOCORTICOID_BIOSYNTHESIS	HSD3B1 HSD3B2	8.28e-04	12	51	2	MM14749
Pathway	KEGG_ARGININE_AND_PROLINE_METABOLISM	NOS1 NOS3 PYCR3	9.72e-04	54	51	3	M2551
Pathway	WP_MALE_STEROID_HORMONES_IN_CARDIOMYOCYTE_ENERGY_METABOLISM	HSD3B1 HSD3B2	9.76e-04	13	51	2	M48060
Pathway	WP_NITRIC_OXIDE_METABOLISM_IN_CYSTIC_FIBROSIS	NOS1 NOS3	9.76e-04	13	51	2	M39894
Pathway	REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE	NOS1 NOS3	9.76e-04	13	51	2	MM15015
Pathway	WP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION	GUCY1B1 NOS1 ADCY3	1.03e-03	55	51	3	M39763
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY	PTCH2 PTCH1	1.14e-03	14	51	2	M47414
Pathway	REACTOME_ANDROGEN_BIOSYNTHESIS	HSD3B1 HSD3B2	1.31e-03	15	51	2	MM14739
Pathway	BIOCARTA_RACC_PATHWAY	GUCY1B1 NOS3	1.31e-03	15	51	2	M22002
Pathway	WP_HEDGEHOG_SIGNALING_WP47	PTCH2 PTCH1	1.49e-03	16	51	2	M39675
Pathway	WP_CLASSICAL_PATHWAY_OF_STEROIDOGENESIS_WITH_GLUCOCORTICOID_AND_MINERALOCORTICOID_METABOLISM	HSD3B1 HSD3B2	1.49e-03	16	51	2	M39815
Pubmed	Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons.	GUCY1B1 NOS1 NOS3	7.08e-07	9	72	3	24155296
Pubmed	HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca2+ concentration via activation of Src kinase and nitric oxide signaling pathways.	GUCY1B1 NOS1 NOS3	7.08e-07	9	72	3	24666322
Pubmed	Isolation and Characterization of Fetal Leydig Progenitor Cells of Male Mice.	PTCH2 HSD3B1 HSD3B2 PTCH1	1.06e-06	37	72	4	26697723
Pubmed	Steroidogenic factor 1 differentially regulates fetal and adult leydig cell development in male mice.	HSD3B1 HSD3B2 PTCH1	1.39e-06	11	72	3	26269506
Pubmed	Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans.	HSD3B1 HSD3B2 NOS1	3.05e-06	14	72	3	12379852
Pubmed	Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol.	HSD3B1 HSD3B2	4.23e-06	2	72	2	14665668
Pubmed	Differential roles of neuronal and endothelial nitric oxide synthases during carrageenan-induced inflammatory hyperalgesia.	NOS1 NOS3	4.23e-06	2	72	2	15350652
Pubmed	Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling.	NOS1 NOS3	4.23e-06	2	72	2	24643800
Pubmed	Intron 4 polymorphism of the endothelial nitric oxide synthase gene is associated with the development of lupus nephritis.	NOS1 NOS3	4.23e-06	2	72	2	15119548
Pubmed	Modulation of the myogenic response in renal blood flow autoregulation by NO depends on endothelial nitric oxide synthase (eNOS), but not neuronal or inducible NOS.	NOS1 NOS3	4.23e-06	2	72	2	21825026
Pubmed	Chronic NOS inhibition actuates endothelial-mesenchymal transformation.	NOS1 NOS3	4.23e-06	2	72	2	16963618
Pubmed	Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.	FCGR2C FCGR2B	4.23e-06	2	72	2	2531080
Pubmed	Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice.	NOS1 NOS3	4.23e-06	2	72	2	8667023
Pubmed	nNOS and eNOS modulate cGMP formation and vascular response in contracting fast-twitch skeletal muscle.	NOS1 NOS3	4.23e-06	2	72	2	11015578
Pubmed	Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein.	TIA1 TIAL1	4.23e-06	2	72	2	17488725
Pubmed	Chaperones rejuvenate folding and activity of 3-β hydroxysteroid dehydrogenase 2.	HSD3B1 HSD3B2	4.23e-06	2	72	2	23485106
Pubmed	Renal cortical and medullary blood flow responses to L-NAME and ANG II in wild-type, nNOS null mutant, and eNOS null mutant mice.	NOS1 NOS3	4.23e-06	2	72	2	15961532
Pubmed	Contributions of endothelial and neuronal nitric oxide synthases to cerebrovascular responses to hyperoxia.	NOS1 NOS3	4.23e-06	2	72	2	14526232
Pubmed	Structure/function of the inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 and type 2 by trilostane.	HSD3B1 HSD3B2	4.23e-06	2	72	2	18524572
Pubmed	Nitric oxide synthase polymorphisms and asthma phenotypes in Chinese children.	NOS1 NOS3	4.23e-06	2	72	2	16238787
Pubmed	Regulation of 3beta-hydroxysteroid dehydrogenase type 1 and type 2 gene expression and function in the human ovarian surface epithelium by cytokines.	HSD3B1 HSD3B2	4.23e-06	2	72	2	19414525
Pubmed	Sustained nitric oxide (NO)-releasing compound reverses dysregulated NO signal transduction in priapism.	NOS1 NOS3	4.23e-06	2	72	2	24076963
Pubmed	Normal development of the ipsilateral retinocollicular pathway and its disruption in double endothelial and neuronal nitric oxide synthase gene knockout mice.	NOS1 NOS3	4.23e-06	2	72	2	11027405
Pubmed	3beta-Hydroxysteroid dehydrogenases and pre-receptor steroid metabolism in the human ovarian surface epithelium.	HSD3B1 HSD3B2	4.23e-06	2	72	2	18778748
Pubmed	Neuronal nitric oxide synthase plays a key role in CNS demyelination.	NOS1 NOS3	4.23e-06	2	72	2	17151270
Pubmed	Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism.	NOS1 NOS3	4.23e-06	2	72	2	18305236
Pubmed	Structure-function relationships of 3 beta-hydroxysteroid dehydrogenase: contribution made by the molecular genetics of 3 beta-hydroxysteroid dehydrogenase deficiency.	HSD3B1 HSD3B2	4.23e-06	2	72	2	9029734
Pubmed	The multiple murine 3 beta-hydroxysteroid dehydrogenase isoforms: structure, function, and tissue- and developmentally specific expression.	HSD3B1 HSD3B2	4.23e-06	2	72	2	9029733
Pubmed	Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells.	HSD3B1 HSD3B2	4.23e-06	2	72	2	2243100
Pubmed	The protein-specific activities of the transmembrane modules of Ptch1 and Ptch2 are determined by their adjacent protein domains.	PTCH2 PTCH1	4.23e-06	2	72	2	30166346
Pubmed	T-cell intracellular antigen (TIA)-proteins deficiency in murine embryonic fibroblasts alters cell cycle progression and induces autophagy.	TIA1 TIAL1	4.23e-06	2	72	2	24086455
Pubmed	Regulation of renin gene expression in kidneys of eNOS- and nNOS-deficient mice.	NOS1 NOS3	4.23e-06	2	72	2	10764216
Pubmed	Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity.	HSD3B1 HSD3B2	4.23e-06	2	72	2	12205101
Pubmed	Repetitive hyperbaric oxygen exposures enhance sensitivity to convulsion by upregulation of eNOS and nNOS.	NOS1 NOS3	4.23e-06	2	72	2	18342297
Pubmed	Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity.	NOS1 NOS3	4.23e-06	2	72	2	7488039
Pubmed	The NOS3 G894T (Glu298Asp) polymorphism is a risk factor for frontotemporal lobar degeneration.	NOS1 NOS3	4.23e-06	2	72	2	19087148
Pubmed	Immunolocalization of murine type VI 3β-hydroxysteroid dehydrogenase in the adrenal gland, testis, skin, and placenta.	HSD3B1 HSD3B2	4.23e-06	2	72	2	24075909
Pubmed	Genetic analysis of NOS isoforms using nNOS and eNOS knockout animals.	NOS1 NOS3	4.23e-06	2	72	2	9932431
Pubmed	Rapid cerebral ischemic preconditioning in mice deficient in endothelial and neuronal nitric oxide synthases.	NOS1 NOS3	4.23e-06	2	72	2	12677017
Pubmed	3β-Hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma.	HSD3B1 HSD3B2	4.23e-06	2	72	2	25458695
Pubmed	Experience-dependent plasticity acts via GluR1 and a novel neuronal nitric oxide synthase-dependent synaptic mechanism in adult cortex.	NOS1 NOS3	4.23e-06	2	72	2	21813683
Pubmed	A novel nonstop mutation in the stop codon and a novel missense mutation in the type II 3beta-hydroxysteroid dehydrogenase (3beta-HSD) gene causing, respectively, nonclassic and classic 3beta-HSD deficiency congenital adrenal hyperplasia.	HSD3B1 HSD3B2	4.23e-06	2	72	2	12050213
Pubmed	Immunohistochemical localization of the 11 beta-hydroxysteroid dehydrogenase type II enzyme in human kidney and placenta.	HSD3B1 HSD3B2	4.23e-06	2	72	2	7608280
Pubmed	Genome-wide profiling reveals a role for T-cell intracellular antigens TIA1 and TIAR in the control of translational specificity in HeLa cells.	TIA1 TIAL1	4.23e-06	2	72	2	24927121
Pubmed	Expression, localization, and regulation of NOS in human mast cell lines: effects on leukotriene production.	NOS1 NOS3	4.23e-06	2	72	2	15044250
Pubmed	Cutaneous neuronal nitric oxide is specifically decreased in postural tachycardia syndrome.	NOS1 NOS3	4.23e-06	2	72	2	17660395
Pubmed	Endothelial Nitric Oxide Synthase Is Present in Dendritic Spines of Neurons in Primary Cultures.	NOS1 NOS3	4.23e-06	2	72	2	28725180
Pubmed	Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR.	TIA1 TIAL1	4.23e-06	2	72	2	8871565
Pubmed	Reproductive function in female mice lacking the gene for endothelial nitric oxide synthase.	NOS1 NOS3	4.23e-06	2	72	2	10534440
Pubmed	Analysis of nitric oxide synthase gene polymorphisms in neonatal respiratory distress syndrome among the Chinese Han population.	NOS1 NOS3	4.23e-06	2	72	2	24602444
Pubmed	Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice.	NOS1 NOS3	4.23e-06	2	72	2	12788381
Pubmed	Angiotensin II response in afferent arterioles of mice lacking either the endothelial or neuronal isoform of nitric oxide synthase.	NOS1 NOS3	4.23e-06	2	72	2	17959704
Pubmed	Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo.	NOS1 NOS3	4.23e-06	2	72	2	9692709
Pubmed	Myocardial and lymphocytic expression of eNOS and nNOS before and after heart transplantation: relationship to clinical status.	NOS1 NOS3	4.23e-06	2	72	2	23770231
Pubmed	Nitric oxide synthase 1 is partly compensating for nitric oxide synthase 3 deficiency in nitric oxide synthase 3 knock-out mice and is elevated in murine and human cirrhosis.	NOS1 NOS3	4.23e-06	2	72	2	15287858
Pubmed	Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance.	NOS1 NOS3	4.23e-06	2	72	2	10905473
Pubmed	Nitric oxide synthase gene polymorphisms in children with minimal change nephrotic syndrome.	NOS1 NOS3	4.23e-06	2	72	2	19371282
Pubmed	Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure.	HSD3B1 HSD3B2	4.23e-06	2	72	2	20660004
Pubmed	Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.	NOS1 NOS3	4.23e-06	2	72	2	11907582
Pubmed	Relative contribution of eNOS and nNOS to endothelium-dependent vasodilation in the mouse aorta.	NOS1 NOS3	4.23e-06	2	72	2	20624383
Pubmed	Neuronal NOS-cGMP-dependent ACh-induced relaxation in pial arterioles of endothelial NOS knockout mice.	NOS1 NOS3	4.23e-06	2	72	2	9486242
Pubmed	Refinement of the ipsilateral retinocollicular projection is disrupted in double endothelial and neuronal nitric oxide synthase gene knockout mice.	NOS1 NOS3	4.23e-06	2	72	2	10727738
Pubmed	Developmental changes in the response of murine cerebellar granule cells to nitric oxide.	NOS1 NOS3	4.23e-06	2	72	2	18406496
Pubmed	Diminished NO generation by injured endothelium and loss of macula densa nNOS may contribute to sustained acute kidney injury after ischemia-reperfusion.	NOS1 NOS3	4.23e-06	2	72	2	18971208
Pubmed	Does endothelial nitric oxide synthase gene variation play a role in the occurrence of hypertension in pregnancy?	NOS1 NOS3	4.23e-06	2	72	2	12908999
Pubmed	Role of nitric oxide synthase on brain GABA transaminase activity and GABA levels.	NOS1 NOS3	4.23e-06	2	72	2	31259693
Pubmed	Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles.	NOS1 NOS3	4.23e-06	2	72	2	11161004
Pubmed	Neuronal and endothelial nitric oxide synthase gene knockout mice.	NOS1 NOS3	4.23e-06	2	72	2	10559836
Pubmed	A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation.	TIA1 TIAL1	4.23e-06	2	72	2	18456862
Pubmed	The cerebral metabolic consequences of nitric oxide synthase deficiency: glucose utilization in endothelial and neuronal nitric oxide synthase null mice.	NOS1 NOS3	4.23e-06	2	72	2	10027769
Pubmed	Physical exercise-associated gene expression signatures in peripheral blood.	FCGR2B HLA-G	4.23e-06	2	72	2	17873550
Pubmed	Low-dose radiation-induced demethylation of 3β-HSD participated in the regulation of testosterone content.	HSD3B1 HSD3B2	4.23e-06	2	72	2	34550611
Pubmed	Priapism in a Fabry disease mouse model is associated with upregulated penile nNOS and eNOS expression.	NOS1 NOS3	4.23e-06	2	72	2	29110178
Pubmed	Carvedilol induces biased β1 adrenergic receptor-nitric oxide synthase 3-cyclic guanylyl monophosphate signalling to promote cardiac contractility.	NOS1 NOS3	4.23e-06	2	72	2	32956449
Pubmed	Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection.	NOS1 NOS3	4.23e-06	2	72	2	11904450
Pubmed	Modulation by NO of acetylcholine release in the ileum of wild-type and NOS gene knockout mice.	NOS1 NOS3	4.23e-06	2	72	2	12381527
Pubmed	The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency.	HSD3B1 HSD3B2	4.23e-06	2	72	2	14764797
Pubmed	Contribution of nNOS- and eNOS-derived NO to microvascular smooth muscle NO exposure.	NOS1 NOS3	4.23e-06	2	72	2	15033959
Pubmed	Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations.	PTCH2 PTCH1	4.23e-06	2	72	2	29230040
Pubmed	Infarct size and nitric oxide synthase in murine myocardium.	NOS1 NOS3	4.23e-06	2	72	2	10652188
Pubmed	High carrier frequency of a nonsense p.Trp230* variant in HSD3B2 gene in Ossetians.	HSD3B1 HSD3B2	4.23e-06	2	72	2	37274334
Pubmed	Multiple forms of mouse 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase and differential expression in gonads, adrenal glands, liver, and kidneys of both sexes.	HSD3B1 HSD3B2	4.23e-06	2	72	2	1924345
Pubmed	Structure of the central RNA recognition motif of human TIA-1 at 1.95A resolution.	TIA1 TIAL1	4.23e-06	2	72	2	18201561
Pubmed	TIA-1 and TIAR interact with 5'-UTR of enterovirus 71 genome and facilitate viral replication.	TIA1 TIAL1	4.23e-06	2	72	2	26363455
Pubmed	TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha.	TIA1 TIAL1	4.23e-06	2	72	2	10921895
Pubmed	Gastric stasis in neuronal nitric oxide synthase-deficient knockout mice.	NOS1 NOS3	4.23e-06	2	72	2	10982771
Pubmed	Effects of water restriction on gene expression in mouse renal medulla: identification of 3betaHSD4 as a collecting duct protein.	HSD3B1 HSD3B2	4.23e-06	2	72	2	16478974
Pubmed	Three populations of adult Leydig cells in mouse testes revealed by a novel mouse HSD3B1-specific rat monoclonal antibody.	HSD3B1 HSD3B2	4.23e-06	2	72	2	30851938
Pubmed	iCLIP predicts the dual splicing effects of TIA-RNA interactions.	TIA1 TIAL1	4.23e-06	2	72	2	21048981
Pubmed	Identification of chosen apoptotic (TIAR and TIA-1) markers expression in thyroid tissues from adolescents with immune and non-immune thyroid diseases.	TIA1 TIAL1	4.23e-06	2	72	2	20675271
Pubmed	Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation.	NOS1 NOS3	4.23e-06	2	72	2	26152695
Pubmed	Alternatively spliced neuronal nitric oxide synthase mediates penile erection.	NOS1 NOS3	4.23e-06	2	72	2	16488973
Pubmed	The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach.	NOS1 NOS3	4.23e-06	2	72	2	19095954
Pubmed	TIA-1 and TIAR activate splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on their own pre-mRNAs.	TIA1 TIAL1	4.23e-06	2	72	2	11514562
Pubmed	Neuronal nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo.	NOS1 NOS3	4.23e-06	2	72	2	18048451
Pubmed	The murine 3 beta-hydroxysteroid dehydrogenase multigene family: structure, function and tissue-specific expression.	HSD3B1 HSD3B2	4.23e-06	2	72	2	7626443
Pubmed	Immunocytochemical distribution of nitric oxide synthase in the human seminal vesicle: a light and electron microscopical study.	NOS1 NOS3	4.23e-06	2	72	2	12802542
Pubmed	Oxygen seizure latency and peroxynitrite formation in mice lacking neuronal or endothelial nitric oxide synthases.	NOS1 NOS3	4.23e-06	2	72	2	12781920
Pubmed	Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS.	NOS1 NOS3	4.23e-06	2	72	2	7518615
Pubmed	Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression.	PTCH2 PTCH1	4.23e-06	2	72	2	26834157
Cytoband	Ensembl 112 genes in cytogenetic band chr1p12	HSD3B1 HSD3B2 WARS2	8.19e-05	53	72	3	chr1p12
Cytoband	1p13.1	HSD3B1 HSD3B2	1.24e-03	33	72	2	1p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr2p23	SLC5A6 MFSD2B ADCY3	1.70e-03	149	72	3	chr2p23
GeneFamily	PDZ domain containing	GRIP1 HTRA2 MAGI3 NOS1	8.19e-04	152	50	4	1220
Coexpression	FOSTER_KDM1A_TARGETS_DN	METRN CELSR3 TIA1 NADK NOS3 SNN	1.69e-05	202	70	6	M2514
Coexpression	FOSTER_KDM1A_TARGETS_DN	METRN CELSR3 TIA1 NADK NOS3 SNN	1.84e-05	205	70	6	MM957
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D231\|Adult / Lineage, Cell type, age group and donor	GHRHR CELSR3 KIAA1217 DISP3 MAGI3	2.41e-06	132	72	5	8d30b71776f5f6da55dc78e0c5cb27be460004e3
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GRIP1 CADM1 KIAA1217 MAGI3 PARM1	1.03e-05	178	72	5	f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HSPG2 PRCP SLC10A6 CDH23 NOS3	1.18e-05	183	72	5	a644258ba90acc62d571623e429d72ffc4b69203
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Microfold_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GHRHR ANO9 SLC5A6 HSD3B2 PARM1	1.18e-05	183	72	5	9a2cd63af5f492d46ce80ca1536312e8ac0e7df4
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GRIP1 CADM1 KIAA1217 MAGI3 PARM1	1.25e-05	185	72	5	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	GRIP1 DUOX1 KIAA1217 MAGI3 PARM1	1.25e-05	185	72	5	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|World / Lineage, Cell type, age group and donor	GRIP1 CADM1 KIAA1217 MAGI3 PARM1	1.31e-05	187	72	5	81cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCell	COVID-19-lung-Vein_EC\|lung / Disease (COVID-19 only), tissue and cell type	HSPG2 PRCP SLC10A6 NOS1 NOS3	1.35e-05	188	72	5	d582b76fc2faac526c9bf97503041129e1a6a211
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	DUOX1 CADM1 KIAA1217 MAGI3 PARM1	1.35e-05	188	72	5	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DUOX1 CADM1 KIAA1217 MAGI3 PARM1	1.45e-05	191	72	5	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	DUOX1 CADM1 KIAA1217 MAGI3 PARM1	1.49e-05	192	72	5	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor_Erythro-Mega\|bone_marrow / Manually curated celltypes from each tissue	HSPG2 SLC39A3 GUCY1B1 MED12L MFSD2B	1.49e-05	192	72	5	cbc304c704e8524eee24a1619d0fbb2cf96c4976
ToppCell	distal-2-Hematologic-Myeloid_Dendritic_Type_2\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GRIP1 FCGR2C FCGR2B MED12L HAPLN4	1.57e-05	194	72	5	6881cfe12837a32e598535a564e4c31d4846167b
ToppCell	distal-Hematologic-Myeloid_Dendritic_Type_2-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GRIP1 FCGR2C FCGR2B MED12L HAPLN4	1.61e-05	195	72	5	7606b8b40e704bb5447ac57ccf8698794e9c7890
ToppCell	Bronchial-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DUOX1 CADM1 KIAA1217 MAGI3 PARM1	1.77e-05	199	72	5	5f7da3eab58ace6cddb3179a415cd839d5767958
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DUOX1 CADM1 KIAA1217 MAGI3 PARM1	1.77e-05	199	72	5	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor-Proliferative_AT1_Progenitor\|E16.5-samps / Age Group, Lineage, Cell class and subclass	NUP210L PTCH2 NOS1 SLC26A6	6.43e-05	133	72	4	b0d3ac5abd9ebd490db46a3ef2e4ae88c4bf4e34
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DISP3 MFSD2B ATG9A ADCY3	9.72e-05	148	72	4	f85dc34f6a4a15ecffa4fbd5644dea12ce30089b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DISP3 MFSD2B ATG9A ADCY3	9.72e-05	148	72	4	4b1fdf90c585f89cee1cf521db4e3fafc9d74d9a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DISP3 MFSD2B ATG9A ADCY3	9.72e-05	148	72	4	55826b7e9f79ab78a93abd4fc662bc37aa121471
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_vein-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HSPG2 STAB2 NOS1 NOS3	1.02e-04	150	72	4	4f31867cb85253ff6d22f3b02ef972a42cb41123
ToppCell	PND01-03-samps-Mesenchymal-Pericyte\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	AJAP1 GUCY1B1 PARM1 FGF22	1.08e-04	152	72	4	fc9472bc19f997103da535b035105f01429cb08e
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_3\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GRIP1 AJAP1 FCGR2B PRCP	1.19e-04	156	72	4	841d653d74c4de41d2f9a114f6ccb92d6a1ebc24
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_3\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GRIP1 AJAP1 FCGR2B PRCP	1.19e-04	156	72	4	a917b3e799a7b2a3c7f36af61f2b69292c0fb5c0
ToppCell	severe_COVID-19-pDC\|World / disease group, cell group and cell class (v2)	HSPG2 AJAP1 MED12L PYCR3	1.28e-04	159	72	4	e1c48c4ceda116826819ff9adeed7bad6a58844d
ToppCell	severe_COVID-19-pDC\|severe_COVID-19 / disease group, cell group and cell class (v2)	HSPG2 AJAP1 MED12L PYCR3	1.28e-04	159	72	4	ea5088d27e42b8850455764d53b757ea8d8f14bc
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC2-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FCGR2C FCGR2B MFSD2B PARM1	1.34e-04	161	72	4	1e9b833a20f5fb936a71cab24c87ff24bc3c8942
ToppCell	droplet-Lung-nan-18m-Myeloid-intermediate_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR2B PILRA PRCP NADK	1.48e-04	165	72	4	e32697321cef424c2ad4e11ee9da3e510d5ce505
ToppCell	droplet-Lung-nan-18m-Myeloid-Intermediate_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR2B PILRA PRCP NADK	1.48e-04	165	72	4	0fbdd043e11aa8dbff4cd3a4da1b2feb49878a09
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HSPG2 PRCP NOS1 NOS3	1.51e-04	166	72	4	f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCell	facs-Heart-LA-18m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CADM1 FCGR2B PILRA TMEM54	1.51e-04	166	72	4	19ec59f0a43d4eb5b4cc7bcd6480ada7f469054b
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CADM1 KIAA1217 MAGI3 PARM1	1.51e-04	166	72	4	c20479fe7a4306320d7f26e78bf956225f00f35a
ToppCell	ICU-NoSEP-Myeloid-cDC2\|ICU-NoSEP / Disease, Lineage and Cell Type	GRIP1 FCGR2B PRCP PARM1	1.55e-04	167	72	4	5b7b731944d888591279ef6167b3ae8cab3f6886
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PILRA HLA-G NADK CDH23	1.62e-04	169	72	4	e3100eb587005e160bd0b7990fa57ec49765133d
ToppCell	PND01-03-samps-Mesenchymal-Pericyte-pericyte_F\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	AJAP1 GUCY1B1 PARM1 FGF22	1.66e-04	170	72	4	71718dcebd48105994c313bb55babc70301170a0
ToppCell	droplet-Lung-nan-18m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMTOR4 FCGR2B PRCP NADK	1.73e-04	172	72	4	35d09640d5b04fa0bbb1b40d4b8f97da587a5046
ToppCell	356C-Myeloid-Monocyte-CD16+_Monocyte\|Monocyte / Donor, Lineage, Cell class and subclass (all cells)	DUOX1 HTRA2 GUCY1B1 WARS2	1.73e-04	172	72	4	9dca1542145d88559527db7e0f6ad150df59ca2d
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	SLC5A6 PKD2 LY75 ADCY3	1.77e-04	173	72	4	efb8072475000888efe088d00e870c56ffad4172
ToppCell	droplet-Lung-nan-21m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR2B PILRA PRCP NADK	1.81e-04	174	72	4	763ca53339d9e236da8463f2a9d1bd39d4385d75
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D231\|Adult / Lineage, Cell type, age group and donor	HSPG2 PRCP NOS1 NOS3	1.81e-04	174	72	4	2dd647c4fdf99fd1f7b838efef01baf2cbc3446d
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	METRN SLC5A6 DDX20 ZSWIM4	1.89e-04	176	72	4	91ad2c34144f72283ca112fd3b3784f2f6259f65
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRIP1 HSPG2 AJAP1 MAGI3	1.93e-04	177	72	4	9af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCell	PND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HSPG2 CADM1 MFSD2B MAGI3	1.98e-04	178	72	4	a3af5d9c55858e36be0498081029ecb0acaeb3d3
ToppCell	PND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HSPG2 CADM1 MFSD2B MAGI3	1.98e-04	178	72	4	b3b88989bd602cfb55bb5c47731deb99288a8952
ToppCell	renal_papilla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 HSPG2 KIAA1217 PKD2	2.06e-04	180	72	4	49829e833fe6d2431cfd2e8f378c2aaa3b2b46a4
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	DUOX1 CADM1 MAGI3 PARM1	2.06e-04	180	72	4	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRIP1 HSPG2 CADM1 MAGI3	2.11e-04	181	72	4	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	Control-Epithelial_cells-Airway_club\|Control / group, cell type (main and fine annotations)	GRIP1 KIAA1217 MAGI3 PARM1	2.11e-04	181	72	4	c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARVCF MED12L DISP3 NOS1	2.15e-04	182	72	4	be32b5b8153c1053cbb55f1fccfa27c3ee97c1e1
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-Microfold_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANO9 HSD3B1 HSD3B2 CDH16	2.15e-04	182	72	4	cee5f1872d6464e380995323544a4cd567add370
ToppCell	3'-Adult-LargeIntestine-Epithelial-Tuft-related-Microfold_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANO9 SLC5A6 SLC45A2 HSD3B2	2.15e-04	182	72	4	b4f347fb684f6840c166d7473f3f56389f69c14b
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 STAB2 FCGR2B NOS3	2.15e-04	182	72	4	b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DUOX1 CADM1 MAGI3 PARM1	2.20e-04	183	72	4	6847c1252d6bb105524f812658112517fd351eab
ToppCell	COVID-19-lung-AT1\|lung / Disease (COVID-19 only), tissue and cell type	GRIP1 DUOX1 CADM1 MAGI3	2.20e-04	183	72	4	942530449e9c6583705eeb8f6f12621daea57252
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	DUOX1 CADM1 MAGI3 PARM1	2.24e-04	184	72	4	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	droplet-Limb_Muscle-nan-21m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CADM1 AJAP1 METRN PTCH2	2.24e-04	184	72	4	9f8cd5ab5af6c35a1be25d70a125b9a3f4dd667a
ToppCell	droplet-Limb_Muscle-nan-21m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CADM1 AJAP1 METRN PTCH2	2.29e-04	185	72	4	3d1353dbcb60e2531ef67e1bd218b7bc4d7c7c9b
ToppCell	droplet-Limb_Muscle-nan-21m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CADM1 AJAP1 METRN PTCH2	2.29e-04	185	72	4	995a8ddc3fd8e6879d8b5de8cbdefe232d34833b
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 ARVCF MFSD2B NOS3	2.34e-04	186	72	4	2cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRIP1 HSPG2 CADM1 MAGI3	2.34e-04	186	72	4	3aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 ARVCF MFSD2B NOS3	2.34e-04	186	72	4	90d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HSPG2 CADM1 KIAA1217 MAGI3	2.38e-04	187	72	4	4ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DUOX1 CADM1 MAGI3 PARM1	2.38e-04	187	72	4	5df9e1f5ca32217af255e76e6fb5afa346337811
ToppCell	COVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	HSPG2 SLC10A6 NOS1 NOS3	2.38e-04	187	72	4	2d20193a6cacdfa4877457c97b0077408942186c
ToppCell	droplet-Heart-HEART-1m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CADM1 AJAP1 METRN ARVCF	2.43e-04	188	72	4	921a2c9212a0f2a00fd72c594d80924f27e8b9b7
ToppCell	Endothelial-A-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	HSPG2 TAAR1 NOS1 NOS3	2.43e-04	188	72	4	0824d567356d360fd8e78e840c30529c139f98a1
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	DUOX1 CADM1 MAGI3 PARM1	2.43e-04	188	72	4	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	droplet-Heart-HEART-1m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CADM1 AJAP1 METRN ARVCF	2.48e-04	189	72	4	a618a1ddf5097a010c6c2c7341f3a0bd46a29c02
ToppCell	tumor_Lung-Fibroblasts-Pericytes\|Fibroblasts / Location, Cell class and cell subclass	CADM1 GUCY1B1 ADCY3 PARM1	2.48e-04	189	72	4	9c407b17d7945e81e1ae6c18452f5d20fb09d563
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HSPG2 DISP3 NOS1 NOS3	2.48e-04	189	72	4	c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCell	droplet-Heart-HEART-1m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CADM1 AJAP1 METRN ARVCF	2.48e-04	189	72	4	4e61f9cd1c06bddb47ebf98affc0f97770e26e8c
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HSPG2 STAB2 FCGR2B PRCP	2.48e-04	189	72	4	1d660bceee449aebf12fc9af4c74af246837b27a
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CADM1 KIAA1217 MAGI3 PARM1	2.53e-04	190	72	4	8aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CADM1 AJAP1 GUCY1B1 PARM1	2.53e-04	190	72	4	7e4d80a3a7f83b6a50f1d0fe82fb6c242c39d5b0
ToppCell	21-Trachea-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	HSPG2 STAB2 FCGR2B PRCP	2.53e-04	190	72	4	bce09634acbc2cfd53666328e8aed8bf8835f845
ToppCell	Control-Endothelial-VE_Venous\|Endothelial / Disease state, Lineage and Cell class	PRCP PKD2 CDH23 NOS1	2.53e-04	190	72	4	4e30155203b4a8c5e496fcbe9348b67b98ebc625
ToppCell	COVID-19-lung-AT2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DUOX1 CADM1 MAGI3 PARM1	2.53e-04	190	72	4	27a1a86620fe9b5ee930d388b32352206485e6d0
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CADM1 AJAP1 GUCY1B1 PARM1	2.53e-04	190	72	4	7fec459cd2ad12c2923a03d098289337c0a4c1d3
ToppCell	21-Trachea-Endothelial-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	HSPG2 STAB2 FCGR2B PRCP	2.53e-04	190	72	4	08437396a98ca9526f69c3a74bbf2929f3c68b8e
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CADM1 KIAA1217 MAGI3 PARM1	2.58e-04	191	72	4	34cc997e4e5c727495f321e6807a84aa124da486
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DUOX1 CADM1 MAGI3 PARM1	2.58e-04	191	72	4	a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	DUOX1 CADM1 MAGI3 PARM1	2.58e-04	191	72	4	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	Influenza_Severe-Non-classical_Monocyte\|Influenza_Severe / Disease group and Cell class	GUCY1B1 PILRA CDH23 SNN	2.58e-04	191	72	4	197edf6feb1cfc71d88e532d74f77305a42a3486
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CADM1 KIAA1217 MAGI3 PARM1	2.58e-04	191	72	4	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	RA-09._Endothelium_I\|World / Chamber and Cluster_Paper	HSPG2 KIAA1217 CDH23 NOS3	2.58e-04	191	72	4	c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC39A3 HLA-G PCSK7 PARM1	2.64e-04	192	72	4	0b954a4e5857dac45d97c491af9b27cb2d1bd339
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	DUOX1 CADM1 MAGI3 PARM1	2.64e-04	192	72	4	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 STAB2 FCGR2B NOS3	2.64e-04	192	72	4	2bfac6b3956265205ca47d06888851ed68b65999
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DUOX1 CADM1 MAGI3 PARM1	2.64e-04	192	72	4	29f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCell	RA-09._Endothelium_I\|RA / Chamber and Cluster_Paper	HSPG2 KIAA1217 CDH23 NOS3	2.64e-04	192	72	4	8a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	DUOX1 CADM1 KIAA1217 MAGI3	2.64e-04	192	72	4	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	367C-Myeloid-Dendritic\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CADM1 FCGR2B PRCP PARM1	2.64e-04	192	72	4	877aaf61d8fc40e7013944a0180306dd0bb0557f
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CADM1 KIAA1217 MAGI3 PARM1	2.64e-04	192	72	4	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CADM1 ARVCF GUCY1B1 PARM1	2.64e-04	192	72	4	158cc5736f154da1cb3186ffbf186eae10483e48
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Vein\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HSPG2 PRCP NOS1 NOS3	2.64e-04	192	72	4	717f3d3bbee4d0f64ba1341ee2b00a407ba1e0f3
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 STAB2 FCGR2B NOS3	2.64e-04	192	72	4	d525f7f088a53110912600a7c9f6d33b9270d534
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CADM1 ARVCF GUCY1B1 PARM1	2.64e-04	192	72	4	f4ff62ac9c53eafbe917706de9af8b2d4bded4d4
ToppCell	(7)_Epithelial-C_(AT2)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	DUOX1 CADM1 TMEM54 PARM1	2.69e-04	193	72	4	a3ca6ab20c8de260e410ddc14d3d202f28b9d6c2
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSPG2 PRCP NOS1 NOS3	2.69e-04	193	72	4	c0f0052c24b7fe9e21d2bc6c38047a8e755f87b6
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DUOX1 CADM1 MAGI3 PARM1	2.69e-04	193	72	4	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
Drug	L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide	NOS1 NOS3	9.32e-06	2	70	2	DB01821
Drug	S-Ethyl-N-Phenyl-Isothiourea	NOS1 NOS3	9.32e-06	2	70	2	DB03707
Drug	3-oxo-delta 5-steroid	HSD3B1 HSD3B2	9.32e-06	2	70	2	CID000439372
Drug	L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide	NOS1 NOS3	9.32e-06	2	70	2	DB02077
Drug	N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine	NOS1 NOS3	9.32e-06	2	70	2	DB02027
Drug	N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE	NOS1 NOS3	9.32e-06	2	70	2	DB08018
Drug	N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine	NOS1 NOS3	9.32e-06	2	70	2	DB08019
Drug	Nitroarginine	NOS1 NOS3	9.32e-06	2	70	2	DB04223
Drug	N-(3-(Aminomethyl)Benzyl)Acetamidine	NOS1 NOS3	2.79e-05	3	70	2	DB02044
Drug	3-Bromo-7-Nitroindazole	NOS1 NOS3	2.79e-05	3	70	2	DB01997
Drug	Metanephrine hydrochloride DL [881-95-8]; Up 200; 17.2uM; MCF7; HT_HG-U133A	GHRHR HSPG2 STAB2 TIAL1 VPS13C NOS1	3.13e-05	196	70	6	1515_UP
Drug	mono-(2-ethylhexyl)phthalate	ANO9 STAB2 CADM1 TDRD9 NUP210L DISP3 PCSK7 CDH23 PTCH1 LY75	3.16e-05	658	70	10	ctd:C016599
Drug	AC1L2V2V	HTRA2 PCSK7 SLC45A2 NOS3	5.11e-05	66	70	4	CID000103587
Drug	turosteride	HSD3B1 HSD3B2	5.57e-05	4	70	2	CID000065986
Drug	(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin	NOS1 NOS3	5.57e-05	4	70	2	DB02692
Drug	Trilostane	HSD3B1 HSD3B2	5.57e-05	4	70	2	DB01108
Drug	AC1L9HIO	NOS1 NOS3	5.57e-05	4	70	2	CID000445158
Drug	potassium ferricyanide	GUCY1B1 NOS3	5.57e-05	4	70	2	ctd:C028033
Drug	C05489	HSD3B1 HSD3B2	5.57e-05	4	70	2	CID000440708
Drug	N-Omega-Hydroxy-L-Arginine	NOS1 NOS3	5.57e-05	4	70	2	DB03144
Drug	cortisone 21-acetate	FCGR2C FCGR2B HSD3B1 HSD3B2	6.45e-05	70	70	4	CID000002863
Drug	CAS 87-33-2	HTRA2 GUCY1B1 NOS1 NOS3	7.60e-05	73	70	4	CID000003780
Drug	ginsenoside Re	PCSK7 NOS1 NOS3	8.63e-05	28	70	3	CID000073149
Drug	Nocloprostum	NOS1 ADCY3 NOS3	8.63e-05	28	70	3	CID006435380
Drug	17alpha, 21-dihydroxypregnenolone	HSD3B1 HSD3B2	9.26e-05	5	70	2	CID000192735
Drug	MDL 20,610	FCGR2C FCGR2B	9.26e-05	5	70	2	CID000128209
Drug	2-ethylhexyldiphenylphosphate	HSD3B1 ADCY3	9.26e-05	5	70	2	ctd:C018535
Drug	S-nitrosoacetylcysteine	GUCY1B1 NOS1 NOS3	9.60e-05	29	70	3	CID000122058
Drug	WIN 32729	PCSK7 HSD3B1 HSD3B2	1.06e-04	30	70	3	CID000054579
Drug	TLCK	HTRA2 TMEM54 PCSK7 SLC45A2 ADCY3	1.27e-04	158	70	5	CID000004427
Drug	acetophenone	SLC45A2 PTCH1 ADCY3	1.29e-04	32	70	3	CID000007410
Drug	MnTM-2-PyP5+	DUOX1 NOS1 NOS3	1.29e-04	32	70	3	CID000153503
Drug	TAN-1030A	FCGR2C FCGR2B	1.39e-04	6	70	2	CID009576886
Drug	21-hydroxypregnenolone	HSD3B1 HSD3B2	1.39e-04	6	70	2	CID000150891
Drug	NapNa	NOS1 NOS3	1.39e-04	6	70	2	CID000128726
Drug	16alpha-OHAD	HSD3B1 HSD3B2	1.39e-04	6	70	2	CID000160789
Drug	N-nitroso-L-arginine	NOS1 NOS3	1.39e-04	6	70	2	CID000127762
Drug	1-hexacosanol	NOS1 NOS3	1.39e-04	6	70	2	ctd:C051942
Drug	epicholesterol	HSPG2 TMEM54 SLC10A6 PTCH2 PCSK7 HSD3B2 PTCH1 ADCY3 NOS3	1.39e-04	636	70	9	CID000000304
Drug	sodium nitroprusside	GUCY1B1 TMEM54 PCSK7 NOS1 ADCY3 NOS3	1.52e-04	261	70	6	CID000045469
Drug	Hy 1	GHRHR HSD3B1 HSD3B2	1.70e-04	35	70	3	CID000535161
Drug	P-NE	GHRHR TIA1 NADK NOS1 NOS3	1.74e-04	169	70	5	CID000446755
Drug	16 alpha-hydroxydehydroepiandrosterone	HSD3B1 HSD3B2	1.94e-04	7	70	2	CID000102030
Drug	TAN-999	FCGR2C FCGR2B	1.94e-04	7	70	2	CID000130283
Drug	AC1NLRUC	NOS1 NOS3	1.94e-04	7	70	2	CID004988604
Drug	AC1MHTIN	FCGR2C FCGR2B	1.94e-04	7	70	2	CID003011133
Disease	Intestinal Perforation	NOS1 NOS3	1.57e-05	3	68	2	C0021845
Disease	BASAL CELL CARCINOMA, SUSCEPTIBILITY TO, 1	PTCH2 PTCH1	3.13e-05	4	68	2	605462
Disease	Basal cell carcinoma, susceptibility to, 1	PTCH2 PTCH1	3.13e-05	4	68	2	cv:C2751544
Disease	Oculo-dento-digital syndrome	PTCH2 PTCH1	3.13e-05	4	68	2	C0812437
Disease	Pigmented Basal Cell Carcinoma	PTCH2 SLC45A2 PTCH1	3.68e-05	28	68	3	C1368275
Disease	Carcinoma, Basal Cell	PTCH2 SLC45A2 PTCH1	4.10e-05	29	68	3	C4721806
Disease	Basal Cell Nevus Syndrome	PTCH2 PTCH1	5.21e-05	5	68	2	C0004779
Disease	Abnormal corpus callosum morphology	SLC5A6 MED12L	7.80e-05	6	68	2	C1842581
Disease	hypertension (biomarker_via_orthology)	HSPG2 HSD3B1 HSD3B2 NOS1 NOS3	1.81e-04	227	68	5	DOID:10763 (biomarker_via_orthology)
Disease	plexin-B2 measurement	FCGR2C FCGR2B	1.86e-04	9	68	2	EFO_0021867
Disease	malaria (implicated_via_orthology)	FCGR2C FCGR2B	1.86e-04	9	68	2	DOID:12365 (implicated_via_orthology)
Disease	hyperprolactinemia (biomarker_via_orthology)	HSD3B1 HSD3B2	1.86e-04	9	68	2	DOID:12700 (biomarker_via_orthology)
Disease	Alzheimer's disease (is_marker_for)	HTRA2 GUCY1B1 HSD3B2 NOS1 NOS3	3.21e-04	257	68	5	DOID:10652 (is_marker_for)
Disease	neuroticism measurement, cognitive function measurement	CADM1 NUP210L KIAA1217 PCDHA10 PTCH1 NOS1 ADCY3	3.25e-04	566	68	7	EFO_0007660, EFO_0008354
Disease	basal cell carcinoma (is_implicated_in)	PTCH2 PTCH1	3.40e-04	12	68	2	DOID:2513 (is_implicated_in)
Disease	Antihypertensive use measurement	HSPG2 ARVCF ADCY3 NOS3 CDH16	3.70e-04	265	68	5	EFO_0009927
Disease	acute kidney failure (biomarker_via_orthology)	PKD2 NOS1 NOS3	3.83e-04	61	68	3	DOID:3021 (biomarker_via_orthology)
Disease	cardiomyopathy (biomarker_via_orthology)	NOS1 NOS3	4.02e-04	13	68	2	DOID:0050700 (biomarker_via_orthology)
Disease	hyperglycemia (is_marker_for)	HSPG2 PTCH1	4.02e-04	13	68	2	DOID:4195 (is_marker_for)
Disease	transient cerebral ischemia (implicated_via_orthology)	HTRA2 NOS1 NOS3	4.41e-04	64	68	3	DOID:224 (implicated_via_orthology)
Disease	Parkinson's disease (implicated_via_orthology)	HTRA2 VPS13C PTCH2 PTCH1	4.82e-04	157	68	4	DOID:14330 (implicated_via_orthology)
Disease	FEV/FEC ratio	HSPG2 FCGR2C CADM1 ARVCF FCGR2B PILRA VPS13C CDH23 PTCH1 ADCY3	4.86e-04	1228	68	10	EFO_0004713
Disease	Schizoaffective disorder-bipolar type	STAB2 PTCH1	6.15e-04	16	68	2	EFO_0009965
Disease	Diabetic Angiopathies	ADCY3 NOS3	6.15e-04	16	68	2	C0011875
Disease	Microangiopathy, Diabetic	ADCY3 NOS3	6.15e-04	16	68	2	C0025945
Disease	low affinity immunoglobulin gamma Fc region receptor II-a measurement	FCGR2C FCGR2B	6.96e-04	17	68	2	EFO_0021969
Disease	portal hypertension (implicated_via_orthology)	NOS1 NOS3	8.72e-04	19	68	2	DOID:10762 (implicated_via_orthology)
Disease	birth weight, parental genotype effect measurement	FCGR2C FCGR2B PTCH1 NOS3	1.02e-03	192	68	4	EFO_0004344, EFO_0005939
Disease	Neutropenia	HTRA2 FCGR2B	1.07e-03	21	68	2	C0027947
Disease	impotence (biomarker_via_orthology)	NOS1 NOS3	1.17e-03	22	68	2	DOID:1875 (biomarker_via_orthology)
Disease	progranulin measurement	GRIP1 CDH23	1.17e-03	22	68	2	EFO_0004625
Disease	platelet-to-lymphocyte ratio	HLA-G MED12L MFSD2B CDH23 ZSWIM4	1.51e-03	363	68	5	EFO_0008446
Disease	low affinity immunoglobulin gamma Fc region receptor II-b measurement	FCGR2C FCGR2B	1.52e-03	25	68	2	EFO_0021970
Disease	lissencephaly (implicated_via_orthology)	NOS1 NOS3	1.77e-03	27	68	2	DOID:0050453 (implicated_via_orthology)
Disease	cystic fibrosis (is_implicated_in)	NOS1 NOS3	1.77e-03	27	68	2	DOID:1485 (is_implicated_in)
Disease	right ventricular diastolic volume measurement	TIAL1 NOS3	1.90e-03	28	68	2	EFO_0021814
Disease	apolipoprotein A 1 measurement, apolipoprotein B measurement	HLA-G HAPLN4 PCSK7	1.96e-03	107	68	3	EFO_0004614, EFO_0004615
Disease	suicidal ideation	GRIP1 CDH23	2.04e-03	29	68	2	EFO_0004320

Protein segments in the cluster

Peptide	Gene	Start	Entry
EVVSVTNGSIVVEFH	UMODL1	846	Q5DID0
SVVIHTACIIDVFGV	HSD3B2	76	P26439
VRHVGVAIVSSALTT	DISP3	1286	Q9P2K9
VVAVLNTIHEIVSDS	ARVCF	776	O00192
VSVIIHTACIIDVFG	HSD3B1	76	P14060
VAVVTGIAVAAIVAA	FCGR2B	226	P31994
SGLAVHQIITITVSL	AJAP1	276	Q9UKB5
EIAVQIHSVITAIGI	DDX20	141	Q9UHI6
TAVVVTGALVHYVTI	ANO9	376	A1A5B4
TSITINDIVHVVDSG	DHX30	736	Q7L2E3
RHTGTATVFVTVLDV	CDH23	1081	Q9H251
VLVTIEASGSSAVHV	HSPG2	2806	P98160
INIRTSVQTVVVGHA	HSPG2	3491	P98160
TAIVLTVLHSVGHVV	DUOX1	1136	Q9NRD9
VVLAAVVTGAAVAAV	HLA-G	316	P17693
TAGVTISRVLHTLEV	MED12L	451	Q86YW9
AGVTVTLTVIAEEEH	MAGI3	926	Q5TCQ9
GVTHDVELQESVITV	METRN	196	Q9UJH8
SVSVAISLEGVHVVD	FRMD8P1	291	Q9BZ68
VAVVTGIAVAAIVAA	FCGR2C	226	P31995
HLITTVQGDGVIVST	NADK	306	O95544
VTVVVVDDGVEHTIQ	PCSK7	181	Q16549
SEVVTFIVSVVVGIV	OR5A2	196	Q8NGI9
ITDTLVAVTISEGAH	PRCP	441	P42785
LISIHSLADVEVVVT	LY75	396	O60449
DHVQGLVLTVLVSAV	MFSD2B	316	A6NFX1
IRSVHVGVVVIKAVS	FGF22	76	Q9HCT0
SVQITIGIHTGEVVT	GUCY1B1	516	Q02153
TILTDTIIAHIGVAA	OR52P1	136	Q8NH57
SGSIAAITVTVIAVV	PARM1	256	Q6UWI2
LEHETLVLVVTSTFG	NOS1	801	P29475
LEHETLVLVVTSTFG	NOS3	561	P29474
VSELVLRSVVAGHVV	PCDHA10	576	Q9Y5I2
HISLETAVGVAVAVT	PILRA	191	Q9UKJ1
AVDHAVIGGVVAVVV	CADM1	371	Q9BY67
VVAADGLIVTNAHVV	HTRA2	186	O43464
ATLIVVHTDGSIVET	DEAF1	146	O75398
VLAVEHVLTTVTLLG	ATG9A	401	Q7Z3C6
HVLTTVTLLGVTVTV	ATG9A	406	Q7Z3C6
TTHGLELTRVTVVDA	REXO1L1P	511	Q8IX06
VSCVVHTLVLGVTVA	ADCY3	196	O60266
GHSISIVALFVAITI	GHRHR	136	Q02643
LSVVFGEHTLLVTVS	LAMTOR4	66	Q0VGL1
VVHVLEGESGSVVVQ	HAPLN4	36	Q86UW8
VFTHVVVAVSVAALV	CELSR3	2541	Q9NYQ7
LAGQVVHTETTEVVL	GRIP1	461	Q9Y3R0
AGTVVVVVITASAVA	SLC45A2	501	Q9UMX9
HEVVVVVQSVAKLVG	CDH16	526	O75309
LSVLLTAATVAGVHV	PET117	11	Q6UWS5
IVGTAVVHGTIQTVN	NUP210L	1136	Q5VU65
IHICTGLESVVLTVT	OR52E5	106	Q8NH55
VAVHAAVTGLSVEEV	WARS2	276	Q9UGM6
HSPTTGVVTVIVILI	SNN	6	O75324
VVSLIESNSVVIIHG	TDRD9	141	Q8NDG6
SAHNSTTVIVVGLIV	SLC5A6	531	Q9Y289
TVVTAAVAGVVLVVV	SLC26A6	266	Q9BXS9
ILVASVGIGVEFTVH	PTCH2	1021	Q9Y6C5
LIASVGIGVEFTVHV	PTCH1	1086	Q13635
TVQVLSSGEVHDIVS	KIAA1217	1391	Q5T5P2
FVGVAVHETLVAVAL	SLC39A3	201	Q9BRY0
VVTTEHILVSVAAGV	PYCR3	91	Q53H96
TSAIVVITSGIAAIV	TMEM54	66	Q969K7
VHGNLELVFTVVSTV	SLC10A6	26	Q3KNW5
ISSDIISTNGIVHII	STAB2	1706	Q8WWQ8
GILVDVNTAEHSTVI	VPS13C	2951	Q709C8
TTLVGNLIVIVSISH	TAAR1	36	Q96RJ0
HSIGSIVSKIDAVIV	PKD2	851	Q13563
SGIQTIGHRVIVSDV	SF3B3	991	Q15393
VTVTGCTVHFVAEDV	GART	936	P22102
RVVHITEDGQVIATS	ZNF407	1901	Q9C0G0
AIVSVNGTTIEGHVV	TIAL1	256	Q01085
IVSVNGTTIEGHVVK	TIA1	266	P31483
EICILHVESISTAGV	ZBTB6	216	Q15916
PVEAATIVAVTGTTH	ZSWIM4	721	Q9H7M6