Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	neurofibrillary tangle	CLU PICALM	1.19e-04	5	73	2	GO:0097418
GeneOntologyCellularComponent	MOZ/MORF histone acetyltransferase complex	KAT6A KAT6B	2.50e-04	7	73	2	GO:0070776
GeneOntologyCellularComponent	H3 histone acetyltransferase complex	KAT6A KAT6B	3.32e-04	8	73	2	GO:0070775
Domain	ZnF_UBP	USP3 USP20 USP33	9.63e-06	11	74	3	SM00290
Domain	Znf_UBP	USP3 USP20 USP33	2.11e-05	14	74	3	IPR001607
Domain	zf-UBP	USP3 USP20 USP33	2.11e-05	14	74	3	PF02148
Domain	ZF_UBP	USP3 USP20 USP33	2.11e-05	14	74	3	PS50271
Domain	MOZ_SAS	KAT6A KAT6B	1.54e-04	5	74	2	PF01853
Domain	HAT_MYST-type	KAT6A KAT6B	1.54e-04	5	74	2	IPR002717
Domain	MYST_HAT	KAT6A KAT6B	1.54e-04	5	74	2	PS51726
Domain	ZINC_FINGER_C2H2_2	TSHZ3 ZNF592 ZNF728 ZSCAN5C ZBTB21 ZFP69B ZC3H7B PRDM4 PRDM15 ZNF583 ZNF181	2.25e-04	775	74	11	PS50157
Domain	ZINC_FINGER_C2H2_1	TSHZ3 ZNF592 ZNF728 ZSCAN5C ZBTB21 ZFP69B ZC3H7B PRDM4 PRDM15 ZNF583 ZNF181	2.30e-04	777	74	11	PS00028
Domain	DUSP	USP20 USP33	2.30e-04	6	74	2	SM00695
Domain	DUSP	USP20 USP33	2.30e-04	6	74	2	PF06337
Domain	Znf_C2H2-like	TSHZ3 ZNF592 ZNF728 ZSCAN5C ZBTB21 ZFP69B ZC3H7B PRDM4 PRDM15 ZNF583 ZNF181	2.83e-04	796	74	11	IPR015880
Domain	Znf_C2H2	TSHZ3 ZNF592 ZNF728 ZSCAN5C ZBTB21 ZFP69B ZC3H7B PRDM4 PRDM15 ZNF583 ZNF181	3.11e-04	805	74	11	IPR007087
Domain	-	USP20 USP33	3.21e-04	7	74	2	3.30.2230.10
Domain	Znf_MYM	ZMYM4 ZMYM6	3.21e-04	7	74	2	IPR010507
Domain	DUSP	USP20 USP33	3.21e-04	7	74	2	PS51283
Domain	zf-FCS	ZMYM4 ZMYM6	3.21e-04	7	74	2	PF06467
Domain	Pept_C19_DUSP	USP20 USP33	3.21e-04	7	74	2	IPR006615
Domain	ZnF_C2H2	TSHZ3 ZNF592 ZNF728 ZSCAN5C ZBTB21 ZFP69B ZC3H7B PRDM4 PRDM15 ZNF583 ZNF181	3.21e-04	808	74	11	SM00355
Domain	zf-C2H2	TSHZ3 ZNF592 ZNF728 ZSCAN5C ZBTB21 ZFP69B PRDM4 PRDM15 ZNF583 ZNF181	3.90e-04	693	74	10	PF00096
Domain	TRASH_dom	ZMYM4 ZMYM6	4.27e-04	8	74	2	IPR011017
Domain	TRASH	ZMYM4 ZMYM6	4.27e-04	8	74	2	SM00746
Domain	H15	KAT6A KAT6B	1.17e-03	13	74	2	SM00526
Domain	H15	KAT6A KAT6B	1.17e-03	13	74	2	PS51504
Domain	Histone_H1/H5_H15	KAT6A KAT6B	1.37e-03	14	74	2	IPR005818
Domain	-	PIK3CB TRRAP	1.79e-03	16	74	2	1.10.1070.11
Domain	PI3Kc	PIK3CB TRRAP	1.79e-03	16	74	2	SM00146
Domain	-	RNF121 KAT6A RNF175 KAT6B USP3 USP20 USP33	1.99e-03	449	74	7	3.30.40.10
Domain	Znf_RING/FYVE/PHD	RNF121 KAT6A RNF175 KAT6B USP3 USP20 USP33	2.25e-03	459	74	7	IPR013083
Domain	PI3/4_kinase_cat_dom	PIK3CB TRRAP	2.27e-03	18	74	2	IPR000403
Domain	PI3_PI4_kinase	PIK3CB TRRAP	2.27e-03	18	74	2	PF00454
Domain	PI3_4_KINASE_3	PIK3CB TRRAP	2.27e-03	18	74	2	PS50290
Domain	PI3_4_KINASE_1	PIK3CB TRRAP	2.27e-03	18	74	2	PS00915
Domain	PI3_4_KINASE_2	PIK3CB TRRAP	2.27e-03	18	74	2	PS00916
Domain	USP_CS	USP3 USP20 USP33	2.28e-03	66	74	3	IPR018200
Domain	USP_1	USP3 USP20 USP33	2.70e-03	70	74	3	PS00972
Domain	UCH	USP3 USP20 USP33	2.81e-03	71	74	3	PF00443
Domain	USP_2	USP3 USP20 USP33	2.81e-03	71	74	3	PS00973
Domain	USP_3	USP3 USP20 USP33	2.93e-03	72	74	3	PS50235
Domain	USP_dom	USP3 USP20 USP33	2.93e-03	72	74	3	IPR028889
Domain	Peptidase_C19_UCH	USP3 USP20 USP33	2.93e-03	72	74	3	IPR001394
Domain	-	GPCPD1 PLCE1	4.38e-03	25	74	2	3.20.20.190
Domain	PLC-like_Pdiesterase_TIM-brl	GPCPD1 PLCE1	4.38e-03	25	74	2	IPR017946
Domain	EF-hand-dom_pair	SLC25A12 SCN3A SMOC2 FLG2 PLCE1	5.62e-03	287	74	5	IPR011992
Domain	Znf_C2H2/integrase_DNA-bd	ZNF728 ZSCAN5C ZBTB21 ZFP69B PRDM4 PRDM15 ZNF583 ZNF181	6.07e-03	694	74	8	IPR013087
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	IPO5 TSHZ3 KIF23 CENPT RB1 ZNF592 KAT6A ZBTB21 TRRAP USP3 PRDM15 ZMYM4	5.99e-09	608	74	12	36089195
Pubmed	Effect of CLU and PICALM polymorphisms on AD risk: A study from south India.	CLU PICALM	4.47e-06	2	74	2	28558900
Pubmed	Regulation of KAT6 Acetyltransferases and Their Roles in Cell Cycle Progression, Stem Cell Maintenance, and Human Disease.	KAT6A KAT6B	4.47e-06	2	74	2	27185879
Pubmed	Association of CLU and PICALM variants with Alzheimer's disease.	CLU PICALM	4.47e-06	2	74	2	20570404
Pubmed	Impact of PICALM and CLU on hippocampal degeneration.	CLU PICALM	4.47e-06	2	74	2	27017968
Pubmed	Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults.	CLU PICALM	4.47e-06	2	74	2	24578178
Pubmed	ERα status of invasive ductal breast carcinoma as a result of regulatory interactions between lysine deacetylases KAT6A and KAT6B.	KAT6A KAT6B	4.47e-06	2	74	2	39505971
Pubmed	LACK OF ASSOCIATIONS BETWEEN CLU AND PICALM GENE POLYMORPHISMS AND ALZHEIMER'S DISEASE IN A TURKISH POPULATION.	CLU PICALM	4.47e-06	2	74	2	26434199
Pubmed	Influence of PICALM and CLU risk variants on beta EEG activity in Alzheimer's disease patients.	CLU PICALM	4.47e-06	2	74	2	34650147
Pubmed	Phospholipase C epsilon (PLCε) induced TRPC6 activation: a common but redundant mechanism in primary podocytes.	TRPC6 PLCE1	4.47e-06	2	74	2	25521631
Pubmed	Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins.	USP20 USP33	4.47e-06	2	74	2	33792613
Pubmed	The double PHD finger domain of MOZ/MYST3 induces α-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification.	KAT6A KAT6B	4.47e-06	2	74	2	24150941
Pubmed	An exploratory study on CLU, CR1 and PICALM and Parkinson disease.	CLU PICALM	1.34e-05	3	74	2	21912625
Pubmed	MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain.	KAT6A KAT6B	1.34e-05	3	74	2	36754959
Pubmed	Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.	CLU PICALM	1.34e-05	3	74	2	20739100
Pubmed	Effect of Alzheimer's disease risk genes on trajectories of cognitive function in the Cardiovascular Health Study.	CLU PICALM	1.34e-05	3	74	2	22952074
Pubmed	Role of CLU, PICALM, and TNK1 Genotypes in Aging With and Without Alzheimer's Disease.	CLU PICALM	1.34e-05	3	74	2	28631188
Pubmed	Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population.	CLU PICALM	1.34e-05	3	74	2	22015308
Pubmed	The benefits of staying active in old age: physical activity counteracts the negative influence of PICALM, BIN1, and CLU risk alleles on episodic memory functioning.	CLU PICALM	1.34e-05	3	74	2	24660791
Pubmed	Lower DNA methylation levels in CpG island shores of CR1, CLU, and PICALM in the blood of Japanese Alzheimer's disease patients.	CLU PICALM	1.34e-05	3	74	2	32991610
Pubmed	Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.	USP20 USP33	1.34e-05	3	74	2	12865408
Pubmed	Sequential two-step cleavage of the retinoblastoma protein by caspase-3/-7 during etoposide-induced apoptosis.	RB1 CASP7	1.34e-05	3	74	2	11420704
Pubmed	Cloning and mapping of members of the MYM family.	ZMYM4 ZMYM6	1.34e-05	3	74	2	10486218
Pubmed	Implication of common and disease specific variants in CLU, CR1, and PICALM.	CLU PICALM	1.34e-05	3	74	2	22402018
Pubmed	Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor.	USP20 USP33	1.34e-05	3	74	2	12056827
Pubmed	Canonical transient receptor potential channel (TRPC)3 and TRPC6 associate with large-conductance Ca2+-activated K+ (BKCa) channels: role in BKCa trafficking to the surface of cultured podocytes.	TRPC6 KCNMA1	1.34e-05	3	74	2	19052171
Pubmed	Tandem PHD fingers of MORF/MOZ acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin.	KAT6A KAT6B	1.34e-05	3	74	2	23063713
Pubmed	Lack of association of CR1, PICALM and CLU gene polymorphisms with Alzheimer disease in a Polish population.	CLU PICALM	1.34e-05	3	74	2	23650005
Pubmed	The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels.	CLU PICALM	1.34e-05	3	74	2	21300948
Pubmed	Replication of CLU, CR1, and PICALM associations with alzheimer disease.	CLU PICALM	1.34e-05	3	74	2	20554627
Pubmed	Association analysis between the rs11136000 single nucleotide polymorphism in clusterin gene, rs3851179 single nucleotide polymorphism in clathrin assembly lymphoid myeloid protein gene and the patients with schizophrenia in the Chinese population.	CLU PICALM	1.34e-05	3	74	2	20738160
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	RNF121 LIMS1 TMCO5A SLC25A12 ACER3 TRPC6 LRRK2 PADI2 CDC14A	1.51e-05	686	74	9	29987050
Pubmed	The adenovirus E1A oncoprotein recruits the cellular TRRAP/GCN5 histone acetyltransferase complex.	RB1 TRRAP	2.67e-05	4	74	2	12743606
Pubmed	Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling.	USP20 USP33	2.67e-05	4	74	2	21525354
Pubmed	The interaction of ETV6 (TEL) and TIP60 requires a functional histone acetyltransferase domain in TIP60.	KAT6A KAT6B	2.67e-05	4	74	2	17980166
Pubmed	Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.	PIK3CB LRRK2	2.67e-05	4	74	2	25854701
Pubmed	Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.	CLU PICALM	2.67e-05	4	74	2	19734902
Pubmed	Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF).	KAT6A KAT6B	2.67e-05	4	74	2	21880731
Pubmed	The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.	USP20 USP33	2.67e-05	4	74	2	19424180
Pubmed	Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.	CLU PICALM	2.67e-05	4	74	2	21347408
Pubmed	Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.	CLU PICALM	2.67e-05	4	74	2	20697030
Pubmed	Human and mouse proteases: a comparative genomic approach.	PRSS42P USP3 USP20 USP33	2.77e-05	81	74	4	12838346
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	TSPAN15 KCNMA1 CASP7 NCOA4 KAT6B GFRA1 PLCE1	2.96e-05	415	74	7	16385451
Pubmed	Posttranslational acetylation of the human immunodeficiency virus type 1 integrase carboxyl-terminal domain is dispensable for viral replication.	KAT6A KAT6B	4.45e-05	5	74	2	17182677
Pubmed	Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory.	CLU PICALM	4.45e-05	5	74	2	22539578
Pubmed	MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2.	KAT6A KAT6B	4.45e-05	5	74	2	11965546
Pubmed	Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals.	CLU PICALM	4.45e-05	5	74	2	21059989
Pubmed	The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease.	CLU PICALM	4.45e-05	5	74	2	21627779
Pubmed	APP, APOE, complement receptor 1, clusterin and PICALM and their involvement in the herpes simplex life cycle.	CLU PICALM	4.45e-05	5	74	2	20674675
Pubmed	Integrated late onset Alzheimer's disease (LOAD) susceptibility genes: Cholesterol metabolism and trafficking perspectives.	CLU PICALM	4.45e-05	5	74	2	27773727
Pubmed	Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice.	RB1 CASP7	6.66e-05	6	74	2	11549719
Pubmed	USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.	USP20 USP33	6.66e-05	6	74	2	23486064
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	IPO5 CLU ADAMTS9 ZNF592 DARS1 PRDM4 PADI2 ZNF583 ZMYM4 ZNF181 USP33	8.30e-05	1285	74	11	35914814
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	IPO5 LIMS1 ADAMTS9 ZNF592 ZMYM4 ZNF181 PLCE1	9.19e-05	497	74	7	23414517
Pubmed	Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.	KAT6A KAT6B	9.31e-05	7	74	2	18794358
Pubmed	MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors.	USP20 USP33	9.31e-05	7	74	2	23166351
Pubmed	Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome.	ZBTB21 PRDM15	9.31e-05	7	74	2	11528125
Pubmed	Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9.	NCOA4 ULK2	9.31e-05	7	74	2	28877469
Pubmed	The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse.	CLU PICALM	9.31e-05	7	74	2	21151910
Pubmed	ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.	KAT6A KAT6B TRRAP	1.00e-04	42	74	3	16387653
Pubmed	Genome-wide analysis of genetic loci associated with Alzheimer disease.	CLU PICALM	1.24e-04	8	74	2	20460622
Pubmed	Caspase-9 can antagonize p53-induced apoptosis by generating a p76(Rb) truncated form of Rb.	RB1 CASP7	1.24e-04	8	74	2	15735701
Pubmed	SMOC1 is a tenascin-C interacting protein over-expressed in brain tumors.	CLU SMOC2	1.24e-04	8	74	2	21349332
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF592 ZBTB21 MTREX ZC3H7B KAT6B PADI2 ZMYM4	1.35e-04	529	74	7	14621295
Pubmed	The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation.	FAM47E USP20 USP33	1.69e-04	50	74	3	26275350
Pubmed	Human transcription factor protein interaction networks.	TSHZ3 KIF23 ERLIN2 DNAH10 RB1 ZNF592 ZBTB21 DARS1 FLG2 TRRAP ZMYM4	2.10e-04	1429	74	11	35140242
Pubmed	Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.	CLU PICALM	2.43e-04	11	74	2	21460841
Pubmed	Acetylation of HIV-1 integrase by p300 regulates viral integration.	KAT6A KAT6B	2.43e-04	11	74	2	16096645
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	DSCC1 USP3 USP20 USP33	2.80e-04	147	74	4	29576527
Pubmed	USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.	USP3 USP20	2.91e-04	12	74	2	27801882
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	ERLIN2 ABHD5 PIK3CB FAM47E PRAMEF2 DSCC1 TRRAP USP3 USP20 USP33	2.93e-04	1242	74	10	30973865
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PKNOX2 ZC3H8 TTC12 KAT6A KCNMA1 SMOC2 KAT6B TRRAP USP3 PRDM15 ZMYM4	2.99e-04	1489	74	11	28611215
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	ADAMTS9 SCN3A GPCPD1 ZMYM6	3.26e-04	153	74	4	10718198
Pubmed	Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes.	IPO5 ERLIN2 USP3	3.51e-04	64	74	3	33141564
Pubmed	Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).	RB1 SCN3A FLG2	3.67e-04	65	74	3	32120844
Pubmed	PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2.	IPO5 ERLIN2 CLU DARS1 FLG2	3.92e-04	290	74	5	32929329
Pubmed	Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway.	RB1 PIK3CB	4.00e-04	14	74	2	18988856
Pubmed	Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies.	ERLIN2 SLC25A12 CLU	4.02e-04	67	74	3	30669930
Pubmed	A protein interaction landscape of breast cancer.	IPO5 SLC25A12 RB1 MCM9 DARS1 MTREX PICALM	4.05e-04	634	74	7	34591612
Pubmed	High-resolution genetic mapping of the gunmetal gene which regulates platelet production.	RB1 CLU	4.61e-04	15	74	2	8833241
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	IPO5 LIMS1 KIF23 PIK3CB MCM9 PRDM4 TRRAP USP3 ULK2 ZMYM4	4.93e-04	1327	74	10	32694731
Pubmed	Targeting β-tubulin:CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca2+ entry, mitochondrial perturbation and caspase overactivation.	ERLIN2 CASP7	5.26e-04	16	74	2	23190606
Pubmed	Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.	IPO5 ERLIN2 CLU PICALM	5.30e-04	174	74	4	32149426
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SLC25A12 RB1 CLU ZNF592 KAT6A ZBTB21 KAT6B TRRAP PADI2	5.95e-04	1116	74	9	31753913
Pubmed	Genome-wide association analysis of age-at-onset in Alzheimer's disease.	ADAMTS9 ZNF592	5.95e-04	17	74	2	22005931
Pubmed	Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.	PIK3CB NCOA4	5.95e-04	17	74	2	25327288
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF728 MTREX ZNF583 ZNF181	6.15e-04	181	74	4	37372979
Pubmed	Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.	LRRK2 FAM47E	6.68e-04	18	74	2	21738487
Pubmed	Genome-wide association study reveals genetic risk underlying Parkinson's disease.	LRRK2 FAM47E	8.28e-04	20	74	2	19915575
Pubmed	Evolutionary breakpoints on human chromosome 21.	ZBTB21 PRDM15	8.28e-04	20	74	2	11707078
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	RB1 ADAMTS9 ZNF592 TOPAZ1 SCN3A SAMD3 USP20	9.74e-04	736	74	7	29676528
Pubmed	Negative modulation of androgen receptor transcriptional activity by Daxx.	RB1 NCOA4	1.00e-03	22	74	2	15572661
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	IPO5 ADAMTS9 ZSCAN5C PRAMEF2 USP33	1.08e-03	363	74	5	14691545
Pubmed	MCM9 Is Required for Mammalian DNA Mismatch Repair.	MCM9 MTREX	1.10e-03	23	74	2	26300262
Pubmed	Genome-wide Identification of Foxf2 Target Genes in Palate Development.	ADAMTS9 SMOC2	1.10e-03	23	74	2	32040930
Pubmed	Proteomic data on the nuclear interactome of human MCM9.	MCM9 MTREX	1.10e-03	23	74	2	26870752
Pubmed	Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development.	ADAMTS9 SMOC2	1.10e-03	23	74	2	33898467
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	KIF23 MCM9 KAT6A DARS1 MTREX ZC3H7B TRRAP	1.16e-03	759	74	7	35915203
Pubmed	USP37 is a SNAI1 deubiquitinase.	USP3 USP20	1.20e-03	24	74	2	31911859
Pubmed	Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice.	RNF121 ACER3	1.20e-03	24	74	2	19706712
Interaction	H3-3A interactions	IPO5 TSHZ3 KIF23 CENPT RB1 ZNF592 KAT6A LRRK2 ZBTB21 TRRAP USP3 PRDM15 ZMYM4	2.18e-06	749	72	13	int:H3-3A
Interaction	TOPAZ1 interactions	TOPAZ1 ULK2 ZMYM4	1.55e-05	14	72	3	int:TOPAZ1
Cytoband	2q24	SLC25A12 SCN3A	1.40e-04	11	74	2	2q24
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	TSHZ3 ZNF592 ZNF728 ZSCAN5C ZBTB21 ZFP69B PRDM4 PRDM15 ZNF583 ZNF181	1.32e-04	718	61	10	28
GeneFamily	Zinc fingers MYM-type	ZMYM4 ZMYM6	1.67e-04	6	61	2	86
GeneFamily	Ubiquitin specific peptidases	USP3 USP20 USP33	8.92e-04	56	61	3	366
GeneFamily	Zinc fingers C2HC-type\|PHD finger proteins\|Lysine acetyltransferases	KAT6A KAT6B	1.30e-03	16	61	2	66
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	KAT6A KAT6B	1.47e-03	17	61	2	486
GeneFamily	Zinc fingers C2H2-type\|PR/SET domain family	PRDM4 PRDM15	1.47e-03	17	61	2	1197
GeneFamily	Zinc fingers CCCH-type	ZC3H8 ZC3H7B	6.20e-03	35	61	2	73
ToppCell	RV-13._Vascular_Smooth_Muscle\|RV / Chamber and Cluster_Paper	ADAMTS9 SCN3A TRPC6 KCNMA1 SMOC2 PLCE1	2.90e-07	161	74	6	47b3b7662cbb671ccc086dc0a0cabd65f63eb5a1
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS9 TOPAZ1 TRPC6 CDC14A PLCE1	6.05e-06	155	74	5	90e629681a72baacc7981b82883866a487638dbc
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS9 TOPAZ1 TRPC6 CDC14A PLCE1	6.05e-06	155	74	5	e7f49e2fdaf184fa6b4e685518004e7deff1316d
ToppCell	normal-na-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	TSPAN15 CLU SAMD3 ZFP69B DSCC1	6.05e-06	155	74	5	08295584395e8d9cfc1b1648f98754b3ac53e587
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS9 TOPAZ1 TRPC6 CDC14A PLCE1	6.05e-06	155	74	5	5a872ca70ae8c30b57f45a6772d7bf565e0c2663
ToppCell	RV-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	ADAMTS9 SCN3A TRPC6 KCNMA1 SMOC2	7.06e-06	160	74	5	29c9b4770d0e73d59cffc7937b179484c76b6dcc
ToppCell	LV-13._Vascular_Smooth_Muscle\|LV / Chamber and Cluster_Paper	ADAMTS9 SCN3A KCNMA1 SMOC2 PLCE1	9.75e-06	171	74	5	e99ecae66530d1ae09330cee408c8f3950b87e67
ToppCell	facs-Heart-LA-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAD51AP2 TMCO5A SCN3A TRPC6 PLCE1	1.15e-05	177	74	5	32fecefba1a55e1f418c9a055236fa11175c692d
ToppCell	facs-Heart-LA-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAD51AP2 TMCO5A SCN3A TRPC6 PLCE1	1.15e-05	177	74	5	1b153fbfe1323dc589de4af73a52149ea5ce6763
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PKNOX2 CLU KCNMA1 ZFP69B SMOC2	1.18e-05	178	74	5	8ec2a25dda96c9cc9c2904b6cb18f75a293f4969
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PKNOX2 CLU KCNMA1 ZFP69B SMOC2	1.18e-05	178	74	5	6c91331196696e0cf239d105f458e3230659fa38
ToppCell	COVID-19-Heart-VSMC\|Heart / Disease (COVID-19 only), tissue and cell type	ADAMTS9 SCN3A KCNMA1 SMOC2 PLCE1	1.22e-05	179	74	5	a69ad6912b5c10bb9f9d800f724c792341e9bab1
ToppCell	metastatic_Lymph_Node-Fibroblasts-COL13A1+_matrix_FBs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	PKNOX2 CLU ADAMTS9 SMOC2 GFRA1	1.50e-05	187	74	5	e04fb35f2f5b120659d06b5ae427ab1ec56d5c36
ToppCell	IPF-Stromal-Pericyte\|World / Disease state, Lineage and Cell class	PKNOX2 ADAMTS9 TRPC6 SMOC2 PLCE1	1.79e-05	194	74	5	1a41da29d5adaf766a84eff0003b959e4523f7f1
ToppCell	IPF-Stromal-Pericyte\|IPF / Disease state, Lineage and Cell class	PKNOX2 ADAMTS9 TRPC6 SMOC2 PLCE1	1.88e-05	196	74	5	8b6ff47ce5291d223f5e639fc45cd9267f418256
Disease	nephrotic syndrome type 2 (is_implicated_in)	TRPC6 PLCE1	3.32e-05	4	70	2	DOID:0080379 (is_implicated_in)
Disease	breast milk measurement	PKNOX2 ABHD5 DARS1 NCOA4	1.20e-04	106	70	4	EFO_0009092
Disease	Mental deterioration	CLU PICALM	1.98e-04	9	70	2	C0234985
Disease	Mild cognitive disorder	CLU PICALM	1.98e-04	9	70	2	C1270972
Disease	proteinuria (biomarker_via_orthology)	CLU TRPC6	2.47e-04	10	70	2	DOID:576 (biomarker_via_orthology)
Disease	taurodeoxycholate measurement	SMOC2 CDC14A	3.61e-04	12	70	2	EFO_0010539
Disease	Impaired cognition	CLU PICALM	4.96e-04	14	70	2	C0338656
Disease	Parkinson disease	CCDC82 CLU LRRK2 FAM47E PRDM15	1.00e-03	321	70	5	MONDO_0005180
Disease	Renal glomerular disease	TRPC6 PLCE1	1.36e-03	23	70	2	C0268731
Disease	Ovarian Serous Adenocarcinoma	LRRK2 TRRAP	1.36e-03	23	70	2	C1335177
Disease	Glomerulopathy Assessment	TRPC6 PLCE1	1.36e-03	23	70	2	C4521256
Disease	glioblastoma (is_implicated_in)	RB1 PIK3CB	1.48e-03	24	70	2	DOID:3068 (is_implicated_in)
Disease	sleep duration	IPO5 PKNOX2 TRPC6 KAT6A ZMYM4	1.70e-03	362	70	5	EFO_0005271
Disease	Vitiligo	CASP7 SMOC2 ZC3H7B	1.80e-03	101	70	3	EFO_0004208
Disease	amyotrophic lateral sclerosis (is_marker_for)	LRRK2 MTREX	2.16e-03	29	70	2	DOID:332 (is_marker_for)
Disease	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	TRPC6 PLCE1	2.31e-03	30	70	2	C1868672

Protein segments in the cluster

Peptide	Gene	Start	Entry
CQEKELLKVMKEYAF	TMCO5A	141	Q8N6Q1
KMLFQKKYDLNELCT	nan	191	A8MVM7
YICEKIMDINKSCKN	BEND5	396	Q7L4P6
CIFVYCMFECFKIKN	ACER3	101	Q9NUN7
NLAMVYRYCCKLNKK	CDC14A	56	Q9UNH5
LKKAQVGDMQYSCCK	CCNI2	331	Q6ZMN8
CSMYGICKVKNIDLK	RB1	706	P06400
ECIFKCMLYLKYPKN	RAD51AP2	606	Q09MP3
QALCCKMSVEYDKFI	RFNG	121	Q9Y644
PKLYLCEFCLKYMKS	KAT6B	746	Q8WYB5
CEFCLKYMKSKNILL	KAT6B	751	Q8WYB5
LTMACNKVLSKEYCK	FLG2	81	Q5D862
DLFCKALKTYNMLCF	KCNMA1	1121	Q12791
CKCFAKVAMDDYLKN	LRRK2	696	Q5S007
VCCMKDNYLFLKEVK	PADI2	311	Q9Y2J8
ACQMLVCYAKELKEG	IPO5	681	O00410
ECYTAMKIAEANKLK	ERLIN2	261	O94905
CDLFACMQLKVDKEK	NCOA4	591	Q13772
KLYLCEFCLKYMKSR	KAT6A	536	Q92794
FKFKLYQECCTIAMT	CCDC82	481	Q8N4S0
KYSGILMKDRCKLFC	ADAMTS9	676	Q9P2N4
VYHDLTCCLTMKKKF	GPCPD1	371	Q9NPB8
MIEHCLKCYGKKYVD	DSCC1	241	Q9BVC3
MEALKQKSLYNCRCK	GFRA1	76	P56159
EMVEKCLDKYFQHLC	CENPT	481	Q96BT3
YNDCSCAKMQDLLKK	CASP7	111	P55210
VCECILIMKGYKELN	DNAH10	3166	Q8IVF4
KDFCNRYITCLKTKM	PKNOX2	156	Q96KN3
EKNLKCDYCDKLFMR	PRDM4	671	Q9UKN5
VANEKALAKCEKYML	KIF23	846	Q02241
VKVLEFERDYMCNKC	MCM9	136	Q9NXL9
ENMYIGKECKRACNK	FAM47E	371	Q6ZV65
KCFDEAQKLIYCLMA	RGS21	106	Q2M5E4
VAYTCKLMELAKNCD	PLCE1	231	Q9P212
LQKDFAAMKKYCKVI	RPL3L	146	Q92901
EFPYDVKCMLAEQKC	SAMD3	151	Q8N6K7
KKFACEVCSKMFYRK	PRDM15	851	P57071
KKMYYNCSCIKEGLI	SLCO6A1	541	Q86UG4
QLYKQMCICADFEKV	DARS1	251	P14868
MQLFGKSYKECVCKI	SCN3A	901	Q9NY46
FVEFDMKPVCKKCYE	LIMS1	291	P48059
FILVECCKIKKMYEQ	PIK3CB	281	P42338
CCKIKKMYEQEMIAI	PIK3CB	286	P42338
IRKLYCYLKEMKTLC	PRAMEF2	221	O60811
CYLKEMKTLCKLVFS	PRAMEF2	226	O60811
KEAEEKMLKCVPCTY	ABHD5	36	Q8WTS1
ELMYKNSFDCFKKVL	SLC25A12	366	O75746
TMSICYLCLIFKVKK	CMKLR2	221	P46091
EECKPCLKQTCMKFY	CLU	111	P10909
INLLEKYFDMKKNQC	PICALM	216	Q13492
EYKKLTCLECMRTFK	ZBTB21	771	Q9ULJ3
KKDCEAYALQMTKLD	MTREX	396	P42285
EKLEEYTKTCMDCLK	SMC1B	436	Q8NDV3
YTKTCMDCLKEKKQQ	SMC1B	441	Q8NDV3
KKCVKKFVEYCDVNN	SMOC2	386	Q9H3U7
QTCPYCKEKVDLKRM	RNF175	271	Q8N4F7
IYKCSCEMVFNKKRH	ZNF592	861	Q92610
FKNIMDFVQKKFKCC	TSPAN15	141	O95858
KLLKCKEYVRSFCML	ZNF728	171	P0DKX0
IMCYEECNKIIQKAL	PRSS42P	226	Q7Z5A4
FCMEKKKINYSCKFL	SLFN12	276	Q8IYM2
TCPYCKEKVDLKRMF	RNF121	271	Q9H920
ELKGDNMYSCERCKK	USP20	551	Q9Y2K6
EGKEDAQKVLKCMYC	TSHZ3	266	Q63HK5
CMDVFKKYININELC	TOPAZ1	1126	Q8N9V7
ERYKFCITMCKKLTE	ULK2	926	Q8IYT8
ELDETELYMCHKCKK	USP3	376	Q9Y6I4
VAIKVFCSGCKKMLY	ZMYM6	86	O95789
EYKKKNKVVAMCDYC	ZMYM6	461	O95789
NKVVAMCDYCKLQKI	ZMYM6	466	O95789
MCDYCKLQKIIKETV	ZMYM6	471	O95789
MKTFECNICEKIFKQ	ZFP69B	276	Q9UJL9
ALKCDEKCTKAYFHM	TTC12	166	Q9H892
EKEFKNDYKKLSMQC	TRPC6	311	Q9Y210
IAICMAYEEKELCKI	TRRAP	1096	Q9Y4A5
ECKDCKKVFTYKANL	ZSCAN5C	441	A6NGD5
YVEKKLLKCNDCEKV	ZNF583	206	Q96ND8
MAMCEYCKIEKIVKE	ZMYM4	726	Q5VZL5
ELKGDNMYSCEKCKK	USP33	581	Q8TEY7
MEKQYECNKCLKVFS	ZNF181	401	Q2M3W8
SYYLCKDMINKQDCK	ZC3H7B	481	Q9UGR2
KKKEMCKFYVQGYCT	ZC3H8	221	Q8N5P1