Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2C KMT2A	2.22e-04	8	57	2	GO:0140945
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2C KMT2A	3.55e-04	10	57	2	GO:0140999
GeneOntologyMolecularFunction	manganese ion transmembrane transporter activity	SLC11A1 ATP13A1	3.55e-04	10	57	2	GO:0005384
GeneOntologyMolecularFunction	cytidine deaminase activity	APOBEC3C APOBEC3F	6.12e-04	13	57	2	GO:0004126
GeneOntologyMolecularFunction	low-density lipoprotein particle binding	SCARB1 LDLR	1.19e-03	18	57	2	GO:0030169
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2C KMT2A	1.47e-03	20	57	2	GO:0042800
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	SCARB1 LDLR	1.62e-03	21	57	2	GO:0030228
GeneOntologyMolecularFunction	protease binding	FN1 BFAR ADAMTSL4 LDLR	1.77e-03	181	57	4	GO:0002020
GeneOntologyMolecularFunction	virus receptor activity	SCARB1 PVR LDLR	1.85e-03	85	57	3	GO:0001618
GeneOntologyMolecularFunction	cargo receptor activity	SCARB1 DMBT1 LDLR	1.85e-03	85	57	3	GO:0038024
GeneOntologyMolecularFunction	exogenous protein binding	SCARB1 PVR LDLR	1.91e-03	86	57	3	GO:0140272
GeneOntologyMolecularFunction	scavenger receptor activity	SCARB1 DMBT1	2.68e-03	27	57	2	GO:0005044
GeneOntologyMolecularFunction	deaminase activity	APOBEC3C APOBEC3F	4.24e-03	34	57	2	GO:0019239
GeneOntologyMolecularFunction	lipoprotein particle binding	SCARB1 LDLR	4.48e-03	35	57	2	GO:0071813
GeneOntologyMolecularFunction	protein-lipid complex binding	SCARB1 LDLR	4.48e-03	35	57	2	GO:0071814
GeneOntologyMolecularFunction	pattern recognition receptor activity	SCARB1 DMBT1	4.48e-03	35	57	2	GO:0038187
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP13A1 TMEM94	4.74e-03	36	57	2	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP13A1 TMEM94	4.74e-03	36	57	2	GO:0015662
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	APOBEC3C APOBEC3F	4.74e-03	36	57	2	GO:0016814
GeneOntologyBiologicalProcess	regulation of phosphatidylcholine catabolic process	SCARB1 LDLR	2.17e-05	3	56	2	GO:0010899
GeneOntologyBiologicalProcess	clearance of foreign intracellular DNA	APOBEC3C APOBEC3F	1.08e-04	6	56	2	GO:0044355
GeneOntologyBiologicalProcess	clearance of foreign intracellular nucleic acids	APOBEC3C APOBEC3F	1.08e-04	6	56	2	GO:0099046
GeneOntologyBiologicalProcess	regulation of phospholipid catabolic process	SCARB1 LDLR	1.51e-04	7	56	2	GO:0060696
GeneOntologyBiologicalProcess	positive regulation of cholesterol storage	SCARB1 SREBF2	2.01e-04	8	56	2	GO:0010886
GeneOntologyBiologicalProcess	viral life cycle	SCARB1 PVR APOBEC3C TRIM68 LDLR APOBEC3F	3.11e-04	340	56	6	GO:0019058
GeneOntologyBiologicalProcess	regulation of phosphatidylcholine metabolic process	SCARB1 LDLR	3.21e-04	10	56	2	GO:0150172
GeneOntologyBiologicalProcess	DNA cytosine deamination	APOBEC3C APOBEC3F	3.21e-04	10	56	2	GO:0070383
GeneOntologyBiologicalProcess	cholesterol homeostasis	SCARB1 INSIG1 SREBF2 LDLR	3.59e-04	124	56	4	GO:0042632
GeneOntologyBiologicalProcess	sterol homeostasis	SCARB1 INSIG1 SREBF2 LDLR	3.70e-04	125	56	4	GO:0055092
GeneOntologyBiologicalProcess	cytidine to uridine editing	APOBEC3C APOBEC3F	4.70e-04	12	56	2	GO:0016554
GeneOntologyBiologicalProcess	manganese ion transmembrane transport	SLC11A1 ATP13A1	4.70e-04	12	56	2	GO:0071421
GeneOntologyBiologicalProcess	regulation of fibroblast proliferation	KMT2C FN1 CTC1 KMT2A	4.95e-04	135	56	4	GO:0048145
GeneOntologyBiologicalProcess	cytidine catabolic process	APOBEC3C APOBEC3F	6.45e-04	14	56	2	GO:0006216
GeneOntologyBiologicalProcess	DNA deamination	APOBEC3C APOBEC3F	6.45e-04	14	56	2	GO:0045006
GeneOntologyBiologicalProcess	manganese ion transport	SLC11A1 ATP13A1	6.45e-04	14	56	2	GO:0006828
GeneOntologyBiologicalProcess	cytidine metabolic process	APOBEC3C APOBEC3F	6.45e-04	14	56	2	GO:0046087
GeneOntologyBiologicalProcess	cytidine deamination	APOBEC3C APOBEC3F	6.45e-04	14	56	2	GO:0009972
GeneOntologyBiologicalProcess	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	PVR CRB2 CRB1	6.71e-04	63	56	3	GO:0007157
GeneOntologyBiologicalProcess	transcription initiation-coupled chromatin remodeling	KMT2A APOBEC3C APOBEC3F	7.35e-04	65	56	3	GO:0045815
GeneOntologyBiologicalProcess	positive regulation of gene expression via chromosomal CpG island demethylation	APOBEC3C APOBEC3F	7.43e-04	15	56	2	GO:0044029
GeneOntologyBiologicalProcess	positive regulation of gene expression, epigenetic	KMT2A APOBEC3C APOBEC3F	8.38e-04	68	56	3	GO:0141137
GeneOntologyBiologicalProcess	SREBP signaling pathway	INSIG1 SREBF2	8.48e-04	16	56	2	GO:0032933
GeneOntologyBiologicalProcess	phosphatidylcholine catabolic process	SCARB1 LDLR	8.48e-04	16	56	2	GO:0034638
GeneOntologyBiologicalProcess	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	APOBEC3C APOBEC3F	8.48e-04	16	56	2	GO:0045869
GeneOntologyBiologicalProcess	cholesterol import	SCARB1 LDLR	8.48e-04	16	56	2	GO:0070508
GeneOntologyBiologicalProcess	pyrimidine ribonucleoside metabolic process	APOBEC3C APOBEC3F	8.48e-04	16	56	2	GO:0046131
GeneOntologyBiologicalProcess	pyrimidine ribonucleoside catabolic process	APOBEC3C APOBEC3F	8.48e-04	16	56	2	GO:0046133
GeneOntologyBiologicalProcess	fibroblast proliferation	KMT2C FN1 CTC1 KMT2A	9.36e-04	160	56	4	GO:0048144
GeneOntologyBiologicalProcess	cellular response to sterol depletion	INSIG1 SREBF2	9.59e-04	17	56	2	GO:0071501
GeneOntologyBiologicalProcess	cholesterol metabolic process	SCARB1 INSIG1 SREBF2 LDLR	1.00e-03	163	56	4	GO:0008203
GeneOntologyBiologicalProcess	high-density lipoprotein particle clearance	SCARB1 LDLR	1.08e-03	18	56	2	GO:0034384
GeneOntologyBiologicalProcess	pyrimidine nucleoside catabolic process	APOBEC3C APOBEC3F	1.08e-03	18	56	2	GO:0046135
GeneOntologyBiologicalProcess	symbiont entry into host cell	SCARB1 PVR TRIM68 LDLR	1.15e-03	169	56	4	GO:0046718
GeneOntologyBiologicalProcess	regulation of single stranded viral RNA replication via double stranded DNA intermediate	APOBEC3C APOBEC3F	1.20e-03	19	56	2	GO:0045091
GeneOntologyBiologicalProcess	base conversion or substitution editing	APOBEC3C APOBEC3F	1.20e-03	19	56	2	GO:0016553
GeneOntologyBiologicalProcess	response to sterol depletion	INSIG1 SREBF2	1.20e-03	19	56	2	GO:0006991
GeneOntologyBiologicalProcess	regulation of lipid catabolic process	HCAR2 SCARB1 LDLR	1.25e-03	78	56	3	GO:0050994
GeneOntologyBiologicalProcess	symbiont entry into host	SCARB1 PVR TRIM68 LDLR	1.33e-03	176	56	4	GO:0044409
GeneOntologyBiologicalProcess	secondary alcohol metabolic process	SCARB1 INSIG1 SREBF2 LDLR	1.33e-03	176	56	4	GO:1902652
GeneOntologyBiologicalProcess	single stranded viral RNA replication via double stranded DNA intermediate	APOBEC3C APOBEC3F	1.33e-03	20	56	2	GO:0039692
GeneOntologyBiologicalProcess	positive regulation of triglyceride biosynthetic process	SCARB1 LDLR	1.33e-03	20	56	2	GO:0010867
GeneOntologyBiologicalProcess	regulation of cholesterol storage	SCARB1 SREBF2	1.33e-03	20	56	2	GO:0010885
GeneOntologyBiologicalProcess	sterol metabolic process	SCARB1 INSIG1 SREBF2 LDLR	1.36e-03	177	56	4	GO:0016125
GeneOntologyCellularComponent	SREBP-SCAP-Insig complex	INSIG1 SREBF2	2.27e-05	3	58	2	GO:0032937
GeneOntologyCellularComponent	subapical complex	CRB2 CRB1	7.53e-05	5	58	2	GO:0035003
Domain	EGF_3	SSPOP LDLR SVEP1 CRB2 CRB1 OTOG GP2	7.07e-06	235	57	7	PS50026
Domain	EGF_1	FN1 SSPOP LDLR SVEP1 CRB2 CRB1 GP2	1.20e-05	255	57	7	PS00022
Domain	hEGF	SVEP1 CRB2 CRB1	8.36e-05	28	57	3	PF12661
Domain	FYrich_C	KMT2C KMT2A	9.10e-05	5	57	2	IPR003889
Domain	FYrich_N	KMT2C KMT2A	9.10e-05	5	57	2	IPR003888
Domain	FYRC	KMT2C KMT2A	9.10e-05	5	57	2	SM00542
Domain	FYRN	KMT2C KMT2A	9.10e-05	5	57	2	SM00541
Domain	FYRN	KMT2C KMT2A	9.10e-05	5	57	2	PF05964
Domain	FYRC	KMT2C KMT2A	9.10e-05	5	57	2	PF05965
Domain	FYRC	KMT2C KMT2A	9.10e-05	5	57	2	PS51543
Domain	FYRN	KMT2C KMT2A	9.10e-05	5	57	2	PS51542
Domain	EGF-like_dom	LDLR SVEP1 CRB2 CRB1 OTOG GP2	1.09e-04	249	57	6	IPR000742
Domain	EGF-like_CS	FN1 LDLR SVEP1 CRB2 CRB1 GP2	1.40e-04	261	57	6	IPR013032
Domain	EGF_2	SSPOP LDLR SVEP1 CRB2 CRB1 GP2	1.53e-04	265	57	6	PS01186
Domain	EGF_Ca-bd_CS	LDLR SVEP1 CRB2 CRB1	2.19e-04	97	57	4	IPR018097
Domain	EGF_CA	LDLR SVEP1 CRB2 CRB1	2.37e-04	99	57	4	PS01187
Domain	ASX_HYDROXYL	LDLR SVEP1 CRB2 CRB1	2.46e-04	100	57	4	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	LDLR SVEP1 CRB2 CRB1	3.07e-04	106	57	4	IPR000152
Domain	ZP_dom_CS	DMBT1 GP2	4.05e-04	10	57	2	IPR017977
Domain	EGF_CA	LDLR SVEP1 CRB2 CRB1	5.24e-04	122	57	4	SM00179
Domain	ConA-like_dom	TRIM68 SVEP1 CRB2 CRB1 TRIM7	5.40e-04	219	57	5	IPR013320
Domain	EGF-like_Ca-bd_dom	LDLR SVEP1 CRB2 CRB1	5.57e-04	124	57	4	IPR001881
Domain	APOBEC_N	APOBEC3C APOBEC3F	5.92e-04	12	57	2	PF08210
Domain	TIL	SSPOP OTOG	5.92e-04	12	57	2	PF01826
Domain	APOBEC_N	APOBEC3C APOBEC3F	5.92e-04	12	57	2	IPR013158
Domain	C8	SSPOP OTOG	5.92e-04	12	57	2	PF08742
Domain	Unchr_dom_Cys-rich	SSPOP OTOG	6.99e-04	13	57	2	IPR014853
Domain	C8	SSPOP OTOG	6.99e-04	13	57	2	SM00832
Domain	-	FN1 ELSPBP1	6.99e-04	13	57	2	2.10.10.10
Domain	FN_type2_col-bd	FN1 ELSPBP1	8.13e-04	14	57	2	IPR000562
Domain	FN2_2	FN1 ELSPBP1	8.13e-04	14	57	2	PS51092
Domain	PLAC	ADAMTSL3 ADAMTSL4	8.13e-04	14	57	2	PF08686
Domain	ZP_1	DMBT1 GP2	8.13e-04	14	57	2	PS00682
Domain	TIL_dom	SSPOP OTOG	8.13e-04	14	57	2	IPR002919
Domain	APOBEC/CMP_deaminase_Zn-bd	APOBEC3C APOBEC3F	8.13e-04	14	57	2	IPR016192
Domain	ZP_2	DMBT1 GP2	8.13e-04	14	57	2	PS51034
Domain	fn2	FN1 ELSPBP1	8.13e-04	14	57	2	PF00040
Domain	FN2_1	FN1 ELSPBP1	8.13e-04	14	57	2	PS00023
Domain	FN2	FN1 ELSPBP1	8.13e-04	14	57	2	SM00059
Domain	CYT_DCMP_DEAMINASES_2	APOBEC3C APOBEC3F	9.37e-04	15	57	2	PS51747
Domain	ZP	DMBT1 GP2	9.37e-04	15	57	2	SM00241
Domain	TSP_1	ADAMTSL3 SSPOP ADAMTSL4	9.40e-04	63	57	3	PF00090
Domain	TSP1	ADAMTSL3 SSPOP ADAMTSL4	1.03e-03	65	57	3	SM00209
Domain	TSP1_rpt	ADAMTSL3 SSPOP ADAMTSL4	1.03e-03	65	57	3	IPR000884
Domain	TSP1	ADAMTSL3 SSPOP ADAMTSL4	1.03e-03	65	57	3	PS50092
Domain	Post-SET_dom	KMT2C KMT2A	1.07e-03	16	57	2	IPR003616
Domain	VWD	SSPOP OTOG	1.07e-03	16	57	2	SM00216
Domain	PostSET	KMT2C KMT2A	1.07e-03	16	57	2	SM00508
Domain	VWF_type-D	SSPOP OTOG	1.07e-03	16	57	2	IPR001846
Domain	VWFD	SSPOP OTOG	1.07e-03	16	57	2	PS51233
Domain	AT_hook	KMT2C KMT2A	1.07e-03	16	57	2	PF02178
Domain	POST_SET	KMT2C KMT2A	1.07e-03	16	57	2	PS50868
Domain	VWD	SSPOP OTOG	1.07e-03	16	57	2	PF00094
Domain	ZP_dom	DMBT1 GP2	1.21e-03	17	57	2	IPR001507
Domain	Zona_pellucida	DMBT1 GP2	1.21e-03	17	57	2	PF00100
Domain	Cytidine_deaminase-like	APOBEC3C APOBEC3F	1.21e-03	17	57	2	IPR016193
Domain	CYT_DCMP_DEAMINASES_1	APOBEC3C APOBEC3F	1.21e-03	17	57	2	PS00903
Domain	CMP_dCMP_Zn-bd	APOBEC3C APOBEC3F	1.21e-03	17	57	2	IPR002125
Domain	Growth_fac_rcpt_	INSRR LDLR SVEP1 CRB1	1.31e-03	156	57	4	IPR009030
Domain	VWC_out	SSPOP OTOG	1.51e-03	19	57	2	SM00215
Domain	PLAC	ADAMTSL3 ADAMTSL4	1.51e-03	19	57	2	PS50900
Domain	PLAC	ADAMTSL3 ADAMTSL4	1.51e-03	19	57	2	IPR010909
Domain	SRCR	CD163L1 DMBT1	1.85e-03	21	57	2	PF00530
Domain	EPHD	KMT2C KMT2A	2.03e-03	22	57	2	PS51805
Domain	SR	CD163L1 DMBT1	2.62e-03	25	57	2	SM00202
Domain	-	CD163L1 DMBT1	2.62e-03	25	57	2	3.10.250.10
Domain	Cys_knot_C	SSPOP OTOG	2.62e-03	25	57	2	IPR006207
Domain	CTCK_2	SSPOP OTOG	2.62e-03	25	57	2	PS01225
Domain	SRCR_1	CD163L1 DMBT1	2.84e-03	26	57	2	PS00420
Domain	SRCR_2	CD163L1 DMBT1	2.84e-03	26	57	2	PS50287
Domain	SRCR-like_dom	CD163L1 DMBT1	2.84e-03	26	57	2	IPR017448
Pathway	WP_STEROL_REGULATORY_ELEMENTBINDING_PROTEINS_SREBP_SIGNALING	SCARB1 INSIG1 SREBF2 LDLR	5.72e-05	71	42	4	M39395
Pathway	BIOCARTA_S1P_PATHWAY	SREBF2 LDLR	1.29e-04	6	42	2	MM1556
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTSL3 SSPOP ADAMTSL4	2.09e-04	39	42	3	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTSL3 SSPOP ADAMTSL4	2.09e-04	39	42	3	MM15165
Pathway	BIOCARTA_S1P_PATHWAY	SREBF2 LDLR	2.40e-04	8	42	2	M22036
Pathway	WP_SREBF_AND_MIR33_IN_CHOLESTEROL_AND_LIPID_HOMEOSTASIS	SREBF2 LDLR	5.61e-04	12	42	2	MM15927
Pathway	WP_FAMILIAL_HYPERLIPIDEMIA_TYPE_3	SCARB1 LDLR	6.62e-04	13	42	2	M42551
Pubmed	The impact of severe LDL receptor mutations on SREBP-pathway regulation in homozygous familial hypercholesterolemia (FH).	SCARB1 SREBF2 LDLR	4.39e-08	5	58	3	22425645
Pubmed	Crumbs proteins regulate layered retinal vascular development required for vision.	CRB2 CRB1	2.73e-06	2	58	2	31718797
Pubmed	Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5.	CRB2 CRB1	2.73e-06	2	58	2	30956116
Pubmed	Relative importance of the LDL receptor and scavenger receptor class B in the beta-VLDL-induced uptake and accumulation of cholesteryl esters by peritoneal macrophages.	SCARB1 LDLR	2.73e-06	2	58	2	10884299
Pubmed	Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development.	SCARB1 LDLR	2.73e-06	2	58	2	15331403
Pubmed	CRB2 acts as a modifying factor of CRB1-related retinal dystrophies in mice.	CRB2 CRB1	2.73e-06	2	58	2	24565864
Pubmed	Hypervariable region 1 deletion and required adaptive envelope mutations confer decreased dependency on scavenger receptor class B type I and low-density lipoprotein receptor for hepatitis C virus.	SCARB1 LDLR	2.73e-06	2	58	2	24257605
Pubmed	CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function.	CRB2 CRB1	2.73e-06	2	58	2	29893966
Pubmed	Interdependent Impact of Lipoprotein Receptors and Lipid-Lowering Drugs on HCV Infectivity.	SCARB1 LDLR	2.73e-06	2	58	2	34209751
Pubmed	Influence of maternal lipid profile on placental protein expression of LDLr and SR-BI.	SCARB1 LDLR	2.73e-06	2	58	2	17531953
Pubmed	A coding variant in SR-BI (I179N) significantly increases atherosclerosis in mice.	SCARB1 LDLR	2.73e-06	2	58	2	23722970
Pubmed	Expression and localization of the polarity protein CRB2 in adult mouse brain: a comparison with the CRB1rd8 mutant mouse model.	CRB2 CRB1	2.73e-06	2	58	2	30076417
Pubmed	Spontaneous and diet-aggravated hemolysis and its correction by probucol in SR-BI knockout mice with LDL-R deficiency.	SCARB1 LDLR	2.73e-06	2	58	2	25983325
Pubmed	Scavenger Receptor Class B Type 1 Deletion Led to Coronary Atherosclerosis and Ischemic Heart Disease in Low-density Lipoprotein Receptor Knockout Mice on Modified Western-type Diet.	SCARB1 LDLR	2.73e-06	2	58	2	27373983
Pubmed	Human CRB1 and CRB2 form homo- and heteromeric protein complexes in the retina.	CRB2 CRB1	2.73e-06	2	58	2	38570189
Pubmed	High-density lipoprotein-associated 17beta-estradiol fatty acyl ester uptake by Fu5AH hepatoma cells: implications of the roles of scavenger receptor class B, type I and the low-density lipoprotein receptor.	SCARB1 LDLR	2.73e-06	2	58	2	17905649
Pubmed	Effect of a combination oral contraceptive (desogestrel+ethinyl estradiol) on the expression of low-density lipoprotein receptor and its transcription factor (SREBP2) in placental trophoblast cells.	SREBF2 LDLR	2.73e-06	2	58	2	21757058
Pubmed	Stromal cell-derived factor-1 alpha improves cardiac function in a novel diet-induced coronary atherosclerosis model, the SR-B1ΔCT/LDLR KO mouse.	SCARB1 LDLR	2.73e-06	2	58	2	38627162
Pubmed	Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1.	SCARB1 LDLR	2.73e-06	2	58	2	10764675
Pubmed	Involvement of scavenger receptor class B type 1 and low-density lipoprotein receptor in the internalization of liposomes into HepG2 cells.	SCARB1 LDLR	2.73e-06	2	58	2	28888368
Pubmed	Human prostate cancer cells lack feedback regulation of low-density lipoprotein receptor and its regulator, SREBP2.	SREBF2 LDLR	2.73e-06	2	58	2	11149418
Pubmed	Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis.	CRB2 CRB1	2.73e-06	2	58	2	24339791
Pubmed	Reversal of adipose tissue loss by probucol in mice with deficiency of both scavenger receptor class B type 1 and LDL receptor on high fat diet.	SCARB1 LDLR	2.73e-06	2	58	2	28522295
Pubmed	Vif Proteins from Diverse Human Immunodeficiency Virus/Simian Immunodeficiency Virus Lineages Have Distinct Binding Sites in A3C.	APOBEC3C APOBEC3F	2.73e-06	2	58	2	27581978
Pubmed	Novel Mouse Model of Myocardial Infarction, Plaque Rupture, and Stroke Shows Improved Survival With Myeloperoxidase Inhibition.	SCARB1 LDLR	2.73e-06	2	58	2	38881440
Pubmed	[Inflammation enhances the accumulation of lipid in ApoE/SRA/CD36 KO mice liver].	SREBF2 LDLR	2.73e-06	2	58	2	20510003
Pubmed	Perturbed cell cycle phase-dependent positioning and nuclear migration of retinal progenitors along the apico-basal axis underlie global retinal disorganization in the LCA8-like mouse model.	CRB2 CRB1	2.73e-06	2	58	2	39284539
Pubmed	Rosmarinic Acid Exhibits a Lipid-Lowering Effect by Modulating the Expression of Reverse Cholesterol Transporters and Lipid Metabolism in High-Fat Diet-Fed Mice.	SCARB1 LDLR	2.73e-06	2	58	2	34680102
Pubmed	Gene transfer and hepatic overexpression of the HDL receptor SR-BI reduces atherosclerosis in the cholesterol-fed LDL receptor-deficient mouse.	SCARB1 LDLR	2.73e-06	2	58	2	10712397
Pubmed	Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.	INSIG1 SREBF2 LDLR	3.53e-06	18	58	3	29899135
Pubmed	SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.	INSIG1 SREBF2 LDLR	4.18e-06	19	58	3	26685326
Pubmed	Small-molecule inhibition of HIV-1 Vif.	APOBEC3C APOBEC3F	8.19e-06	3	58	2	18806783
Pubmed	Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis.	SREBF2 LDLR	8.19e-06	3	58	2	22666465
Pubmed	Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells.	SREBF2 LDLR	8.19e-06	3	58	2	16014965
Pubmed	Enhancing immunity to HIV through APOBEC.	APOBEC3C APOBEC3F	8.19e-06	3	58	2	18846074
Pubmed	Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background.	CRB2 CRB1	8.19e-06	3	58	2	24324803
Pubmed	The APOBEC3C crystal structure and the interface for HIV-1 Vif binding.	APOBEC3C APOBEC3F	8.19e-06	3	58	2	23001005
Pubmed	Nuclear import of APOBEC3F-labeled HIV-1 preintegration complexes.	APOBEC3C APOBEC3F	8.19e-06	3	58	2	24248339
Pubmed	HDL activates expression of genes stimulating cholesterol efflux in human monocyte-derived macrophages.	INSIG1 LDLR	8.19e-06	3	58	2	30118702
Pubmed	Cholesterol metabolism and expression of its relevant genes in cultured steatotic hepatocytes.	SREBF2 LDLR	8.19e-06	3	58	2	19906111
Pubmed	Identification of specific determinants of human APOBEC3F, APOBEC3C, and APOBEC3DE and African green monkey APOBEC3F that interact with HIV-1 Vif.	APOBEC3C APOBEC3F	8.19e-06	3	58	2	20943965
Pubmed	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	KMT2C KMT2A	8.19e-06	3	58	2	23932714
Pubmed	Role of leptin on the expression of low density lipoprotein receptor.	SREBF2 LDLR	8.19e-06	3	58	2	25488447
Pubmed	MLL histone methylases regulate expression of HDLR-SR-B1 in presence of estrogen and control plasma cholesterol in vivo.	SCARB1 KMT2A	8.19e-06	3	58	2	23192982
Pubmed	Lymphatic vessels are essential for the removal of cholesterol from peripheral tissues by SR-BI-mediated transport of HDL.	SCARB1 LDLR	8.19e-06	3	58	2	23663736
Pubmed	FLII and MLL1 Cooperatively Regulate Aryl Hydrocarbon Receptor-Mediated Transcription in ARPE-19 Cells.	FLII KMT2A	8.19e-06	3	58	2	34698116
Pubmed	Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression.	HCAR2 LDLR	8.19e-06	3	58	2	22914621
Pubmed	Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide.	HCAR2 LDLR	8.19e-06	3	58	2	31710686
Pubmed	Identification of a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein.	APOBEC3C APOBEC3F	8.19e-06	3	58	2	25724652
Pubmed	Macrophage SR-BI mediates efferocytosis via Src/PI3K/Rac1 signaling and reduces atherosclerotic lesion necrosis.	SCARB1 LDLR	8.19e-06	3	58	2	26059978
Pubmed	Overexpression of human CRB1 or related isoforms, CRB2 and CRB3, does not regulate the human presenilin complex in culture cells.	CRB2 CRB1	8.19e-06	3	58	2	17988153
Pubmed	SR-BI (Scavenger Receptor Class B Type 1) Is Critical in Maintaining Normal T-Cell Development and Enhancing Thymic Regeneration.	SCARB1 LDLR	8.19e-06	3	58	2	30354229
Pubmed	TNFα-Induced LDL Cholesterol Accumulation Involve Elevated LDLR Cell Surface Levels and SR-B1 Downregulation in Human Arterial Endothelial Cells.	SCARB1 LDLR	8.19e-06	3	58	2	34207810
Pubmed	Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein.	SCARB1 LDLR	8.19e-06	3	58	2	16461760
Pubmed	Resveratrol increases the expression and activity of the low density lipoprotein receptor in hepatocytes by the proteolytic activation of the sterol regulatory element-binding proteins.	SREBF2 LDLR	8.19e-06	3	58	2	22153697
Pubmed	Enhanced foam cell formation, atherosclerotic lesion development, and inflammation by combined deletion of ABCA1 and SR-BI in Bone marrow-derived cells in LDL receptor knockout mice on western-type diet.	SCARB1 LDLR	8.19e-06	3	58	2	21071707
Pubmed	Targeted deletion of Crb1/Crb2 in the optic vesicle models key features of leber congenital amaurosis 8.	CRB2 CRB1	8.19e-06	3	58	2	31145883
Pubmed	CRB2 Loss in Rod Photoreceptors Is Associated with Progressive Loss of Retinal Contrast Sensitivity.	CRB2 CRB1	8.19e-06	3	58	2	31438467
Pubmed	Extensive diet-induced atherosclerosis in scavenger receptor class B type 1-deficient mice is associated with substantial leukocytosis and elevated vascular cell adhesion molecule-1 expression in coronary artery endothelium.	SCARB1 LDLR	8.19e-06	3	58	2	36714321
Pubmed	Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.	INSIG1 SREBF2	8.19e-06	3	58	2	15085196
Pubmed	Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells.	HCAR2 LDLR	8.19e-06	3	58	2	21317532
Pubmed	Structural Insights into HIV-1 Vif-APOBEC3F Interaction.	APOBEC3C APOBEC3F	8.19e-06	3	58	2	26537685
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ENGASE FLII KMT2C CTC1 ATP13A1 TMEM94 SCARB1 SUFU LDLR TRIM7	1.31e-05	1105	58	10	35748872
Pubmed	Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.	SCARB1 SREBF2 LDLR	1.56e-05	29	58	3	20167577
Pubmed	HIV-1 Vif interaction with APOBEC3 deaminases and its characterization by a new sensitive assay.	APOBEC3C APOBEC3F	1.64e-05	4	58	2	21279453
Pubmed	Distinct determinants in HIV-1 Vif and human APOBEC3 proteins are required for the suppression of diverse host anti-viral proteins.	APOBEC3C APOBEC3F	1.64e-05	4	58	2	19088851
Pubmed	Molecular genetic analysis of familial hypercholesterolemia: spectrum and regional difference of LDL receptor gene mutations in Japanese population.	SCARB1 LDLR	1.64e-05	4	58	2	12417285
Pubmed	Structural features of antiviral DNA cytidine deaminases.	APOBEC3C APOBEC3F	1.64e-05	4	58	2	23787464
Pubmed	Interactions among genetic variants from SREBP2 activating-related pathway on risk of coronary heart disease in Chinese Han population.	INSIG1 SREBF2	1.64e-05	4	58	2	19740467
Pubmed	Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs.	INSIG1 SREBF2	1.64e-05	4	58	2	12842885
Pubmed	Identification of a linkage group including the Bcg gene by restriction fragment length polymorphism analysis.	SLC11A1 FN1	1.64e-05	4	58	2	2901325
Pubmed	Hormone-sensitive lipase deficiency affects the expression of SR-BI, LDLr, and ABCA1 receptors/transporters involved in cellular cholesterol uptake and efflux and disturbs fertility in mouse testis.	SCARB1 LDLR	1.64e-05	4	58	2	34461308
Pubmed	A patch of positively charged amino acids surrounding the human immunodeficiency virus type 1 Vif SLVx4Yx9Y motif influences its interaction with APOBEC3G.	APOBEC3C APOBEC3F	1.64e-05	4	58	2	19535450
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2C KMT2A	1.64e-05	4	58	2	23129768
Pubmed	Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.	KMT2C KMT2A	1.64e-05	4	58	2	19703992
Pubmed	Quantitative trait locus analysis of plasma lipoprotein levels in an autoimmune mouse model : interactions between lipoprotein metabolism, autoimmune disease, and atherogenesis.	SCARB1 SREBF2	1.64e-05	4	58	2	9974430
Pubmed	Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake.	SCARB1 LDLR	1.64e-05	4	58	2	34551590
Pubmed	Restriction by APOBEC3 proteins of endogenous retroviruses with an extracellular life cycle: ex vivo effects and in vivo "traces" on the murine IAPE and human HERV-K elements.	APOBEC3C APOBEC3F	1.64e-05	4	58	2	18702815
Pubmed	The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.	KMT2C KMT2A	1.64e-05	4	58	2	24081332
Pubmed	Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport.	SCARB1 LDLR	1.64e-05	4	58	2	17709636
Pubmed	Hepatic overexpression of idol increases circulating protein convertase subtilisin/kexin type 9 in mice and hamsters via dual mechanisms: sterol regulatory element-binding protein 2 and low-density lipoprotein receptor-dependent pathways.	SREBF2 LDLR	1.64e-05	4	58	2	24675665
Pubmed	Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.	INSIG1 SREBF2	1.64e-05	4	58	2	12202038
Pubmed	Species-specific restriction of apobec3-mediated hypermutation.	APOBEC3C APOBEC3F	1.64e-05	4	58	2	18032489
Pubmed	Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.	SCARB1 SREBF2 LDLR	1.91e-05	31	58	3	20031551
Pubmed	Cholesteryl ester transfer protein (CETP) expression enhances HDL cholesteryl ester liver delivery, which is independent of scavenger receptor BI, LDL receptor related protein and possibly LDL receptor.	SCARB1 LDLR	2.72e-05	5	58	2	17055779
Pubmed	TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.	SREBF2 LDLR	2.72e-05	5	58	2	34347016
Pubmed	Regulation of APOBEC3 proteins by a novel YXXL motif in human immunodeficiency virus type 1 Vif and simian immunodeficiency virus SIVagm Vif.	APOBEC3C APOBEC3F	2.72e-05	5	58	2	19109396
Pubmed	HIV-1 Vif, APOBEC, and intrinsic immunity.	APOBEC3C APOBEC3F	2.72e-05	5	58	2	18577210
Pubmed	Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?	INSIG1 SREBF2	2.72e-05	5	58	2	18195716
Pubmed	AID and APOBECs span the gap between innate and adaptive immunity.	APOBEC3C APOBEC3F	2.72e-05	5	58	2	25352838
Pubmed	Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes.	SCARB1 LDLR	2.72e-05	5	58	2	18175806
Pubmed	The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements.	APOBEC3C APOBEC3F	2.72e-05	5	58	2	18304004
Pubmed	Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.	INSIG1 SREBF2	2.72e-05	5	58	2	16100574
Pubmed	Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.	INSIG1 SREBF2	2.72e-05	5	58	2	12242332
Pubmed	Host restriction of HIV-1 by APOBEC3 and viral evasion through Vif.	APOBEC3C APOBEC3F	2.72e-05	5	58	2	20012521
Pubmed	A computational analysis of the structural determinants of APOBEC3's catalytic activity and vulnerability to HIV-1 Vif.	APOBEC3C APOBEC3F	2.72e-05	5	58	2	25461536
Pubmed	Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo.	SCARB1 LDLR	2.72e-05	5	58	2	18992221
Pubmed	Small-molecule inhibition of human immunodeficiency virus type 1 replication by targeting the interaction between Vif and ElonginC.	APOBEC3C APOBEC3F	2.72e-05	5	58	2	22379088
Pubmed	Human immunodeficiency virus type 1 Vif functionally interacts with diverse APOBEC3 cytidine deaminases and moves with them between cytoplasmic sites of mRNA metabolism.	APOBEC3C APOBEC3F	2.72e-05	5	58	2	17977970
Pubmed	Epidermolysis bullosa - a group of skin diseases with different causes but commonalities in gene expression.	FN1 LDLR	2.72e-05	5	58	2	22716248
Interaction	KMT2B interactions	KMT2C SELENBP1 ZNF330 TNRC6A KMT2A RERE	1.60e-06	130	56	6	int:KMT2B
Cytoband	2q34	FN1 SPAG16	5.81e-04	28	58	2	2q34
Cytoband	10q26.13	DMBT1 EDRF1	1.07e-03	38	58	2	10q26.13
Cytoband	Ensembl 112 genes in cytogenetic band chr7q36	KMT2C INSIG1 SSPOP	1.09e-03	159	58	3	chr7q36
Cytoband	Ensembl 112 genes in cytogenetic band chr10q26	FANK1 DMBT1 EDRF1	2.32e-03	207	58	3	chr10q26
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZC3H4 PVR ZNF112 ZNF285 PPP1R13L ELSPBP1	3.88e-03	1192	58	6	chr19q13
Cytoband	7q36.1	KMT2C SSPOP	4.00e-03	74	58	2	7q36.1
Cytoband	19q13.32	ZC3H4 PPP1R13L	4.00e-03	74	58	2	19q13.32
Cytoband	12q24.31	HCAR2 SCARB1	4.65e-03	80	58	2	12q24.31
Cytoband	22q13.1	APOBEC3C APOBEC3F	5.24e-03	85	58	2	22q13.1
GeneFamily	ADAMTS like	ADAMTSL3 ADAMTSL4	1.05e-04	7	41	2	947
GeneFamily	PDZ domain containing\|Crumbs complex	CRB2 CRB1	1.79e-04	9	41	2	1223
GeneFamily	Apolipoprotein B mRNA editing enzyme catalytic subunits	APOBEC3C APOBEC3F	3.26e-04	12	41	2	406
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	CD163L1 SCARB1	1.70e-03	27	41	2	1253
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2C KMT2A	2.69e-03	34	41	2	487
GeneFamily	Fibronectin type III domain containing	FANK1 FN1 INSRR	5.67e-03	160	41	3	555
Coexpression	NABA_ECM_GLYCOPROTEINS	FN1 DMBT1 ELSPBP1 SSPOP SVEP1 OTOG	4.74e-06	196	58	6	M3008
Coexpression	SCHMIDT_POR_TARGETS_IN_LIMB_BUD_UP	INSIG1 SREBF2 LDLR	2.90e-05	27	58	3	M2383
Coexpression	NABA_CORE_MATRISOME	FN1 DMBT1 ELSPBP1 SSPOP SVEP1 OTOG	3.24e-05	275	58	6	M5884
Coexpression	SCHMIDT_POR_TARGETS_IN_LIMB_BUD_UP	INSIG1 SREBF2 LDLR	3.24e-05	28	58	3	MM1310
Coexpression	NABA_ECM_GLYCOPROTEINS	FN1 DMBT1 SSPOP SVEP1 OTOG	6.53e-05	191	58	5	MM17059
Coexpression	GSE20715_WT_VS_TLR4_KO_LUNG_DN	TNRC6A KMT2A ZNF112 DMBT1 GCSAM	7.93e-05	199	58	5	M4350
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2C INSRR KMT2A RERE LDLR	5.52e-06	195	58	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2C INSRR KMT2A RERE LDLR	5.52e-06	195	58	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	PND01-03-samps-Mesenchymal-Pericyte-pericyte_E\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ENGASE ADAMTSL3 OTOG GCSAM	2.90e-05	135	58	4	35928195cf34f055b353562c96f451aef2344d64
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ENHO FN1 INSIG1 PVR	5.49e-05	159	58	4	210ac7fa89514a84f38d9f42254e38fbc2bc5f42
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 DMBT1 OTOG GP2	5.77e-05	161	58	4	b9a17f41426bf715f30bf544a6795afaf37a3aa6
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 DMBT1 OTOG GP2	5.77e-05	161	58	4	f7a89c481f789f624102857be722c95fbeb47595
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTC1 PVR SREBF2 BFAR	6.34e-05	165	58	4	7c771f22b58989572c939ed127e637ec28dc0dca
ToppCell	droplet-Spleen-SPLEEN-1m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC11A1 SELENBP1 FN1 SCARB1	7.12e-05	170	58	4	7cb7ad9ab064b6ea452545d145e5b1d4090cd4c1
ToppCell	droplet-Spleen-SPLEEN-1m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC11A1 SELENBP1 FN1 SCARB1	7.12e-05	170	58	4	db7cee7e518debb2cbe9eeae05d47e14b69cb8e3
ToppCell	facs-Trachea-nan-24m-Epithelial-basal_epithelial_cell_of_tracheobronchial_tree\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HCAR2 SELENBP1 INSRR DMBT1	7.28e-05	171	58	4	d2a10e94b0490120d1420b944302eb841f902c64
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Alveolar_Mac\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	HCAR2 SLC11A1 FN1 ADAMTSL4	7.62e-05	173	58	4	4efa0878ed1ede8fa5d6c191a76d4f70558ba761
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Dedifferentiated_Liposarcoma\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	CD163L1 SUFU ADAMTSL4 SVEP1	7.96e-05	175	58	4	2eca4c168dea2017ea0e383006e28abed22f32ec
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HCAR2 SLC11A1 FN1 ADAMTSL4	8.51e-05	178	58	4	0b398656f26c4061b11ccf98908d0e2e1367585a
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 ADAMTSL3 ADAMTSL4 SVEP1	8.69e-05	179	58	4	dcd0a83f0592ae27f814d064b4791f84c3c86e64
ToppCell	facs-Pancreas-Exocrine-24m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELENBP1 FN1 DMBT1 GP2	8.88e-05	180	58	4	72310baeed848f2c483ae986cd73d2fb2cca7feb
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	SPATA6 FN1 ADAMTSL4 SVEP1	1.03e-04	187	58	4	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELENBP1 DMBT1 ADAMTSL4 GP2	1.03e-04	187	58	4	9aa411ae9b5a923378a5daebb8bb2fc2613f2510
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic\|GI_large-bowel / Manually curated celltypes from each tissue	SLC11A1 FN1 ZNF112 ZNF285	1.05e-04	188	58	4	d0045fdda757d191dabc7853f6a6e99c0e97d93d
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic-Classical_monocytes\|GI_large-bowel / Manually curated celltypes from each tissue	SLC11A1 FN1 ZNF112 ZNF285	1.05e-04	188	58	4	0bcf04aa47738f43c1a87dae5dc487738ee86f8c
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_2\|356C / Donor, Lineage, Cell class and subclass (all cells)	HCAR2 SLC11A1 FN1 ADAMTSL4	1.09e-04	190	58	4	4cce4ddb79b7751d0103e10f71156977e0c34439
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage_2\|343B / Donor, Lineage, Cell class and subclass (all cells)	HCAR2 SLC11A1 FN1 ADAMTSL4	1.09e-04	190	58	4	6514f00d222eef08c282face7f177259bca62f0e
ToppCell	Macrophages-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	SLC11A1 FN1 CD163L1 ADAMTSL4	1.09e-04	190	58	4	8c49622a43422c07659f74edffe1ceab87621381
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SELENBP1 INSIG1 DMBT1 LDLR	1.12e-04	191	58	4	2b0d55a8e1b4ce862dd038f8e0429e8428fb8aba
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.0.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HCAR2 SLC11A1 FN1 ADAMTSL4	1.12e-04	191	58	4	723dc09607e791e9517a22c6482d6cd6b07ce1d6
ToppCell	tumor_Lung-Myeloid_cells-Alveolar_Mac\|tumor_Lung / Location, Cell class and cell subclass	HCAR2 SLC11A1 FN1 ADAMTSL4	1.14e-04	192	58	4	44eda67501e69799c5981be602c143d12f5f222f
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage_4\|343B / Donor, Lineage, Cell class and subclass (all cells)	HCAR2 SLC11A1 FN1 ADAMTSL4	1.16e-04	193	58	4	b9dcffd28ca309359fb110fb79de8ce066208ee1
ToppCell	facs-Pancreas-Exocrine-3m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELENBP1 DMBT1 ADAMTSL4 GP2	1.16e-04	193	58	4	c3161a14a40323a58aa202c8a1d6ea0e9c2b9814
ToppCell	RV-02._Fibroblast_II\|RV / Chamber and Cluster_Paper	SPATA6 FN1 ADAMTSL3 SVEP1	1.19e-04	194	58	4	11c79a8c56ece42713b04b321982e41e239f07a5
ToppCell	LV-02._Fibroblast_II\|LV / Chamber and Cluster_Paper	SPATA6 FN1 ADAMTSL3 SVEP1	1.19e-04	194	58	4	014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage\|367C / Donor, Lineage, Cell class and subclass (all cells)	HCAR2 SLC11A1 FN1 ADAMTSL4	1.19e-04	194	58	4	40c91ed945bd5990a0dbf2090d37a660b19aaab2
ToppCell	normal_Lung\|World / Location, Cell class and cell subclass	HCAR2 SLC11A1 FN1 ADAMTSL4	1.19e-04	194	58	4	affae83d7f982d18117f5b95705f09809f304b0b
ToppCell	343B-Myeloid-Macrophage\|343B / Donor, Lineage, Cell class and subclass (all cells)	HCAR2 SLC11A1 FN1 ADAMTSL4	1.21e-04	195	58	4	48ba2044d2459c8b0d17bc7deca8d0195ac6a00e
ToppCell	COVID-19-Heart-Fib_1\|Heart / Disease (COVID-19 only), tissue and cell type	SPATA6 FN1 ADAMTSL3 SVEP1	1.21e-04	195	58	4	f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENHO INSIG1 INSRR LDLR	1.21e-04	195	58	4	58b769da05a8f6b05aeb08d4f8b112941087ad00
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	HCAR2 SLC11A1 FN1 ADAMTSL4	1.21e-04	195	58	4	f664fe18856065baaa2837fc82ea946e45f6fcc3
ToppCell	tumor_Lung-Myeloid_cells-Alveolar_Mac\|Myeloid_cells / Location, Cell class and cell subclass	HCAR2 SLC11A1 FN1 ADAMTSL4	1.21e-04	195	58	4	3133591a289c06396cf4705d6a861369e145ac54
ToppCell	ASK440-Epithelial-Type_2\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	SELENBP1 INSIG1 DMBT1 LDLR	1.23e-04	196	58	4	754b4202b617165c6994a0b5a9b1e486dccdd44d
ToppCell	ASK440-Epithelial-Type_2\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	SELENBP1 INSIG1 DMBT1 LDLR	1.26e-04	197	58	4	08d5bbeb77a4152af1c783bc958afcae24667767
ToppCell	distal-Hematologic-Alveolar_Macrophage-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HCAR2 SLC11A1 FN1 ADAMTSL4	1.28e-04	198	58	4	cd56124ff98a194ec030588dac684535a31cb5e4
ToppCell	distal-Hematologic-Alveolar_Macrophage-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HCAR2 SLC11A1 FN1 ADAMTSL4	1.31e-04	199	58	4	2918967da22602404c767d948fed6c4754e53518
ToppCell	distal-3-Hematologic-Alveolar_Macrophage\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HCAR2 SLC11A1 FN1 ADAMTSL4	1.31e-04	199	58	4	f57ba6c711e16fe46f8ddc70223576906b3a710b
ToppCell	ASK454-Immune-B_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	SLC11A1 SELENBP1 DMBT1 LDLR	1.31e-04	199	58	4	cbfabf8e895abe454606b990f99e3738f4263ffe
ToppCell	ASK454-Immune-B_cell\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	SLC11A1 SELENBP1 DMBT1 LDLR	1.31e-04	199	58	4	b9b0ae81b9e7e35023c73d3b936e88167461ba54
ToppCell	Mild-Myeloid-Macrophages-FABP4+\|Mild / Condition, Lineage, Cell class and cell subclass	HCAR2 SLC11A1 FN1 ADAMTSL4	1.31e-04	199	58	4	7bfd6ca4b0f2683715c24dfd7cf40418b5b8ddf2
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HCAR2 SLC11A1 FN1 ADAMTSL4	1.31e-04	199	58	4	8e9862907b15809d083216e7d6a0f435015e5d15
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	HCAR2 SLC11A1 FN1 ADAMTSL4	1.33e-04	200	58	4	980cb0390586d8312890e8d0f3cf58e3309d16c5
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	HCAR2 SLC11A1 FN1 ADAMTSL4	1.33e-04	200	58	4	0cf7208eab0dc58fbea35e256c5cb55cdd4a4928
ToppCell	390C-Endothelial_cells-Endothelial-B_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FN1 PVR LDLR TRIM7	1.33e-04	200	58	4	c32ad15dede3f879007c0b856f2fed1f5b058103
ToppCell	proximal-Epithelial-Signaling_Alveolar_Epithelial_Type_2-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SELENBP1 SREBF2 DMBT1 LDLR	1.33e-04	200	58	4	7bd76884fcffdbd9b8d24f5b6b5187ad3963da5f
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 ADAMTSL3 ADAMTSL4 SVEP1	1.33e-04	200	58	4	6f7f015b5fa1f52374f2c7d9ba339012395eda5f
ToppCell	proximal-Epithelial-Signaling_Alveolar_Epithelial_Type_2\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SELENBP1 SREBF2 DMBT1 LDLR	1.33e-04	200	58	4	af57f837eb7f988d24fc4612d16d68121498f0b0
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 ADAMTSL3 ADAMTSL4 SVEP1	1.33e-04	200	58	4	3a164e3971bcd62b148b813171c103adb81f972e
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Macrophage_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	HCAR2 SLC11A1 FN1 ADAMTSL4	1.33e-04	200	58	4	d7d971586c01152b3d21956fd98280588cb8f08b
ToppCell	390C-Endothelial_cells-Endothelial-B_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FN1 PVR LDLR TRIM7	1.33e-04	200	58	4	8a2c6c53a39fab86750526083f7254b7413b29af
ToppCell	proximal-3-Epithelial-Signaling_Alveolar_Epithelial_Type_2\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SELENBP1 SREBF2 DMBT1 LDLR	1.33e-04	200	58	4	9c7859659843b1566bdf623b269b5e166c89d38c
Drug	Tolbutamide [64-77-7]; Up 200; 14.8uM; PC3; HT_HG-U133A	SPATA6 FN1 ERAP1 SCARB1 DMBT1 ELSPBP1 EDRF1	6.76e-07	197	58	7	4540_UP
Drug	Reserpine [50-55-5]; Up 200; 6.6uM; PC3; HT_HG-U133A	CTC1 SCARB1 INSIG1 PVR DMBT1 LDLR	1.02e-05	195	58	6	4203_UP
Drug	Sertaconazole nitrate [99592-39-9]; Up 200; 8uM; PC3; HT_HG-U133A	SLC11A1 FN1 ERAP1 KMT2A RERE ELSPBP1	1.08e-05	197	58	6	4475_UP
Drug	Iproniazide phosphate [305-33-9]; Up 200; 14.4uM; PC3; HT_HG-U133A	FN1 SCARB1 PVR KMT2A RERE EDRF1	1.11e-05	198	58	6	2125_UP
Drug	Sulfachloropyridazine [80-32-0]; Down 200; 14uM; MCF7; HT_HG-U133A	ERAP1 PVR KMT2A RERE ADAMTSL3 EDRF1	1.11e-05	198	58	6	3944_DN
Drug	Fipexide hydrochloride [34161-23-4]; Up 200; 9.4uM; PC3; HT_HG-U133A	SLC11A1 SPATA6 ERAP1 SCARB1 RERE ELSPBP1	1.18e-05	200	58	6	5737_UP
Drug	Ezetimibe	SCARB1 SREBF2 LDLR	1.73e-05	20	58	3	ctd:D000069438
Drug	GW 707	SREBF2 LDLR	1.91e-05	3	58	2	ctd:C442817
Drug	linalool	FN1 INSIG1 SREBF2 LDLR	3.43e-05	72	58	4	ctd:C018584
Drug	N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide	SREBF2 LDLR	3.81e-05	4	58	2	ctd:C511794
Drug	Digitoxigenin [143-62-4]; Up 200; 10.6uM; MCF7; HT_HG-U133A	INSIG1 KMT2A RERE LDLR EDRF1	6.32e-05	165	58	5	3275_UP
Drug	Thiostrepton [1393-48-2]; Up 200; 2.4uM; MCF7; HT_HG-U133A	SLC11A1 FN1 INSIG1 ADAMTSL3 LDLR	8.13e-05	174	58	5	2823_UP
Drug	Metergoline [17692-51-2]; Up 200; 10uM; MCF7; HT_HG-U133A	ERAP1 INSIG1 LDLR EDRF1 GP2	1.03e-04	183	58	5	3221_UP
Drug	Bisacodyl [603-50-9]; Up 200; 11uM; MCF7; HT_HG-U133A	SLC11A1 SPATA6 KMT2A EDRF1 GP2	1.03e-04	183	58	5	5677_UP
Drug	H-7 dihydrochloride; Down 200; 100uM; PC3; HT_HG-U133A	ZC3H4 INSIG1 TRIM68 LDLR EDRF1	1.06e-04	184	58	5	5968_DN
Drug	Tetrandrine [518-34-3]; Up 200; 6.4uM; MCF7; HT_HG-U133A	SLC11A1 INSIG1 DMBT1 LDLR GP2	1.08e-04	185	58	5	6082_UP
Drug	Mometasone furoate [83919-23-7]; Up 200; 7.6uM; PC3; HT_HG-U133A	INSIG1 PVR SREBF2 DMBT1 LDLR	1.14e-04	187	58	5	5116_UP
Drug	LY 294002; Down 200; 10uM; HL60; HT_HG-U133A	FLII FN1 ZNF330 SCARB1 PVR	1.17e-04	188	58	5	6186_DN
Drug	Promazine hydrochloride [53-60-1]; Up 200; 12.4uM; MCF7; HT_HG-U133A	SLC11A1 FN1 INSIG1 PVR EDA2R	1.26e-04	191	58	5	6028_UP
Drug	Norethynodrel [68-23-5]; Up 200; 13.4uM; MCF7; HT_HG-U133A	FN1 ERAP1 INSIG1 EDRF1 SVEP1	1.29e-04	192	58	5	1696_UP
Drug	Piperacetazine [3819-00-9]; Up 200; 9.8uM; MCF7; HT_HG-U133A	SLC11A1 INSIG1 PVR ELSPBP1 EDRF1	1.29e-04	192	58	5	7191_UP
Drug	Methantheline bromide [53-46-3]; Down 200; 9.6uM; MCF7; HT_HG-U133A	FN1 ERAP1 TMEM94 SREBF2 KMT2A	1.29e-04	192	58	5	6254_DN
Drug	Guanabenz acetate [23256-50-0]; Down 200; 13.8uM; PC3; HG-U133A	SLC11A1 ERAP1 TMEM94 KMT2A DELE1	1.32e-04	193	58	5	1961_DN
Drug	Dehydroisoandosterone 3-acetate [853-23-6]; Up 200; 12.2uM; PC3; HT_HG-U133A	FN1 SCARB1 PVR ELSPBP1 SVEP1	1.36e-04	194	58	5	6673_UP
Drug	Antimycin A [1397-94-0]; Up 200; 7.2uM; MCF7; HT_HG-U133A	SPATA6 INSIG1 SREBF2 LDLR EDRF1	1.36e-04	194	58	5	5472_UP
Drug	clofibrate; Up 200; 150uM; MCF7; HG-U133A	SLC11A1 PVR DELE1 RERE ADAMTSL4	1.36e-04	194	58	5	263_UP
Drug	Oxethazaine [126-27-2]; Up 200; 8.6uM; PC3; HG-U133A	ATP13A1 INSIG1 SREBF2 TRIM68 LDLR	1.39e-04	195	58	5	1903_UP
Drug	Sulfamerazine [127-79-7]; Down 200; 15.2uM; MCF7; HT_HG-U133A	PVR SREBF2 KMT2A RERE ELSPBP1	1.39e-04	195	58	5	4740_DN
Drug	Levonordefrin [829-74-3]; Down 200; 21.8uM; HL60; HT_HG-U133A	SLC11A1 FN1 SCARB1 PVR RERE	1.42e-04	196	58	5	2710_DN
Drug	Guaifenesin [93-14-1]; Up 200; 20.2uM; HL60; HT_HG-U133A	SLC11A1 RERE DMBT1 EDRF1 GP2	1.42e-04	196	58	5	2569_UP
Drug	Aminocaproic acid [60-32-2]; Up 200; 30.4uM; HL60; HT_HG-U133A	FN1 CTC1 ADAMTSL4 SNRNP200 SVEP1	1.42e-04	196	58	5	3122_UP
Drug	(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Up 200; 11.8uM; MCF7; HT_HG-U133A	SLC11A1 FN1 PVR KMT2A SNRNP200	1.42e-04	196	58	5	6053_UP
Drug	Acyclovir [59277-89-3]; Up 200; 17.8uM; PC3; HT_HG-U133A	FN1 PVR KMT2A RERE EDRF1	1.42e-04	196	58	5	4683_UP
Drug	Benfotiamine [22457-89-2]; Up 200; 8.6uM; MCF7; HT_HG-U133A	PVR KMT2A RERE EDRF1 SVEP1	1.42e-04	196	58	5	3837_UP
Drug	Estrone [53-16-7]; Up 200; 14.8uM; PC3; HT_HG-U133A	SPATA6 SCARB1 PVR KMT2A RERE	1.42e-04	196	58	5	6647_UP
Drug	Flucloxacillin sodium [1847-24-1]; Down 200; 8.4uM; PC3; HT_HG-U133A	SCARB1 INSIG1 RERE EDRF1 SVEP1	1.42e-04	196	58	5	5102_DN
Drug	Medrysone [2668-66-8]; Up 200; 11.6uM; PC3; HT_HG-U133A	SLC11A1 DMBT1 FHL3 ELSPBP1 SVEP1	1.42e-04	196	58	5	3705_UP
Drug	Maprotiline hydrochloride [10347-81-6]; Up 200; 12.8uM; PC3; HT_HG-U133A	SLC11A1 SCARB1 INSIG1 ELSPBP1 LDLR	1.42e-04	196	58	5	6676_UP
Drug	Terconazole [67915-31-5]; Up 200; 7.6uM; MCF7; HT_HG-U133A	SLC11A1 INSIG1 ELSPBP1 LDLR SVEP1	1.42e-04	196	58	5	4407_UP
Drug	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	INSIG1 RERE LDLR EDA2R	1.44e-04	104	58	4	ctd:C000595015
Drug	25-hydroxycholesterol	INSIG1 SREBF2 LDLR	1.45e-04	40	58	3	ctd:C007997
Drug	Doxepin hydrochloride [1229-29-4]; Up 200; 12.6uM; PC3; HT_HG-U133A	ERAP1 SCARB1 PVR RERE EDRF1	1.46e-04	197	58	5	6337_UP
Drug	Phentolamine hydrochloride [73-05-2]; Up 200; 12.6uM; PC3; HT_HG-U133A	SLC11A1 ERAP1 DMBT1 FHL3 CRB1	1.46e-04	197	58	5	4336_UP
Drug	Sulfanilamide [63-74-1]; Down 200; 23.2uM; HL60; HT_HG-U133A	ERAP1 PVR KMT2A APOBEC3C RERE	1.46e-04	197	58	5	2709_DN
Drug	Etoposide [33419-42-0]; Up 200; 6.8uM; PC3; HT_HG-U133A	SLC11A1 SCARB1 PVR KMT2A EDRF1	1.46e-04	197	58	5	6681_UP
Drug	Deoxycorticosterone [64-85-7]; Down 200; 12.2uM; HL60; HT_HG-U133A	FN1 SCARB1 SREBF2 KMT2A RERE	1.46e-04	197	58	5	3099_DN
Drug	Benzydamine hydrochloride [132-69-4]; Up 200; 11.6uM; MCF7; HT_HG-U133A	SLC11A1 INSIG1 PVR DELE1 RERE	1.46e-04	197	58	5	7169_UP
Drug	Ondansetron Hydrochloride [103639-04-9]; Up 200; 12.2uM; PC3; HT_HG-U133A	SLC11A1 FN1 PVR ELSPBP1 SNRNP200	1.46e-04	197	58	5	5796_UP
Drug	Tolnaftate [2398-96-1]; Up 200; 13uM; MCF7; HT_HG-U133A	ENGASE FN1 PVR APOBEC3C ADAMTSL3	1.46e-04	197	58	5	1501_UP
Drug	Hymecromone [90-33-5]; Up 200; 22.8uM; MCF7; HT_HG-U133A	SLC11A1 ADAMTSL4 EDRF1 SVEP1 GP2	1.46e-04	197	58	5	5684_UP
Drug	Tobramycin [32986-56-4]; Up 200; 8.6uM; MCF7; HT_HG-U133A	ENGASE PVR SREBF2 DMBT1 ELSPBP1	1.49e-04	198	58	5	2841_UP
Drug	Benzamil hydrochloride [2898-76-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A	SLC11A1 PVR SPAG16 ADAMTSL4 SNRNP200	1.49e-04	198	58	5	6056_UP
Drug	Brompheniramine maleate [980-71-2]; Up 200; 9.2uM; PC3; HT_HG-U133A	SLC11A1 FN1 SCARB1 SNRNP200 EDRF1	1.49e-04	198	58	5	4013_UP
Drug	Ald1.1-H_000455; Down 200; 10uM; MCF7; HT_HG-U133A	FN1 SCARB1 RERE LDLR GP2	1.49e-04	198	58	5	7516_DN
Drug	clozapine; Up 200; 10uM; HL60; HT_HG-U133A	ERAP1 APOBEC3C RERE SPAG16 ELSPBP1	1.49e-04	198	58	5	1170_UP
Drug	Pancuronium bromide [15500-66-0]; Up 200; 5.4uM; HL60; HT_HG-U133A	SLC11A1 FN1 PVR ADAMTSL3 CRB1	1.49e-04	198	58	5	2909_UP
Drug	Oxybenzone [131-57-7]; Down 200; 17.6uM; HL60; HT_HG-U133A	CTC1 SCARB1 KMT2A RERE ELSPBP1	1.49e-04	198	58	5	3092_DN
Drug	Epitiostanol [2363-58-8]; Up 200; 13uM; PC3; HT_HG-U133A	FN1 CTC1 ERAP1 SCARB1 KMT2A	1.53e-04	199	58	5	4204_UP
Drug	Tropine [120-29-6]; Up 200; 28.4uM; PC3; HT_HG-U133A	ERAP1 PVR DMBT1 ELSPBP1 GP2	1.53e-04	199	58	5	5790_UP
Drug	Cimetidine [51481-61-9]; Up 200; 15.8uM; HL60; HG-U133A	FN1 SREBF2 DMBT1 LDLR GP2	1.53e-04	199	58	5	1964_UP
Drug	tetraethylenepentamine pentahydrochloride; Up 200; 10uM; MCF7; HG-U133A	SLC11A1 SCARB1 PVR FHL3 GP2	1.53e-04	199	58	5	405_UP
Drug	Doxylamine succinate [562-10-7]; Up 200; 10.2uM; MCF7; HT_HG-U133A	ENGASE SLC11A1 FN1 ZNF330 RERE	1.53e-04	199	58	5	1473_UP
Drug	Cloxacillin sodium salt [642-78-4]; Up 200; 8.8uM; MCF7; HT_HG-U133A	ENGASE CTC1 PVR PPP1R13L ELSPBP1	1.56e-04	200	58	5	7483_UP
Drug	Piracetam [7491-74-9]; Down 200; 28.2uM; HL60; HG-U133A	ENGASE PVR DMBT1 PPP1R13L ELSPBP1	1.56e-04	200	58	5	1710_DN
Drug	Metformin hydrochloride [1115-70-4]; Up 200; 24.2uM; MCF7; HT_HG-U133A	ERAP1 PVR ELSPBP1 ADAMTSL4 EDRF1	1.56e-04	200	58	5	5487_UP
Drug	estradiol, USP; Down 200; 0.01uM; PC3; HG-U133A	SLC11A1 KMT2A DMBT1 LDLR EDRF1	1.56e-04	200	58	5	665_DN
Drug	C0761	APOBEC3C APOBEC3F	1.77e-04	8	58	2	CID006321196
Drug	N-cyclopropylammelide	APOBEC3C APOBEC3F	1.77e-04	8	58	2	CID000592814
Drug	Pyoverdin	SELENBP1 FN1 PVR	1.80e-04	43	58	3	CID005289234
Drug	EM-652	SCARB1 SREBF2 LDLR	2.66e-04	49	58	3	CID000155435
Drug	Desmosterol	INSIG1 LDLR	2.83e-04	10	58	2	ctd:D003897
Drug	di-n-pentyl phthalate	SCARB1 INSIG1 LDLR	3.00e-04	51	58	3	ctd:C034171
Disease	retinitis pigmentosa (implicated_via_orthology)	SNRNP200 CRB2 CRB1	2.04e-05	27	58	3	DOID:10584 (implicated_via_orthology)
Disease	Exudative retinopathy	CTC1 CRB1	2.27e-05	4	58	2	C0154832
Disease	metabolic syndrome	HCAR2 ZC3H4 TNRC6A KMT2A LDLR	4.66e-05	200	58	5	EFO_0000195
Disease	dietary heme iron intake measurement, type 2 diabetes mellitus	TNRC6A SVEP1	5.67e-05	6	58	2	EFO_0008355, MONDO_0005148
Disease	apolipoprotein B measurement	FN1 SCARB1 PVR ZNF112 ZNF285 PPP1R13L LDLR	3.12e-04	663	58	7	EFO_0004615
Disease	Leukemia, Myelocytic, Acute	KMT2C CTC1 PVR KMT2A	3.78e-04	173	58	4	C0023467
Disease	Colorectal Carcinoma	KMT2C SELENBP1 FN1 FHL3 ADAMTSL3 SNRNP200 EDRF1	4.39e-04	702	58	7	C0009402
Disease	Hypercholesterolemia, Familial	SREBF2 LDLR	5.69e-04	18	58	2	C0020445
Disease	Neurodevelopmental Disorders	KMT2C ZC3H4 KMT2A	8.25e-04	93	58	3	C1535926
Disease	Alzheimer disease, polygenic risk score	PVR SREBF2 ZNF112 ZNF285 PPP1R13L LDLR	1.01e-03	586	58	6	EFO_0030082, MONDO_0004975
Disease	Alzheimer disease, high density lipoprotein cholesterol measurement	SCARB1 PVR	1.20e-03	26	58	2	EFO_0004612, MONDO_0004975
Disease	Acute monocytic leukemia	CTC1 KMT2A	1.20e-03	26	58	2	C0023465
Disease	Hyalinosis, Segmental Glomerular	FN1 CRB2	1.39e-03	28	58	2	C0086432
Disease	Carcinoma, Granular Cell	KMT2C SELENBP1 KMT2A	1.56e-03	116	58	3	C0205644
Disease	Adenocarcinoma, Tubular	KMT2C SELENBP1 KMT2A	1.56e-03	116	58	3	C0205645
Disease	Adenocarcinoma, Oxyphilic	KMT2C SELENBP1 KMT2A	1.56e-03	116	58	3	C0205642
Disease	Carcinoma, Cribriform	KMT2C SELENBP1 KMT2A	1.56e-03	116	58	3	C0205643
Disease	Adenocarcinoma, Basal Cell	KMT2C SELENBP1 KMT2A	1.56e-03	116	58	3	C0205641
Disease	Adenocarcinoma	KMT2C SELENBP1 KMT2A	1.56e-03	116	58	3	C0001418
Disease	blood pressure, chronic obstructive pulmonary disease	TNRC6A RERE	1.81e-03	32	58	2	EFO_0000341, EFO_0004325
Disease	Acute Myeloid Leukemia, M1	KMT2C PVR KMT2A	1.93e-03	125	58	3	C0026998
Disease	Acute Myeloid Leukemia (AML-M2)	KMT2C PVR KMT2A	1.93e-03	125	58	3	C1879321

Protein segments in the cluster

Peptide	Gene	Start	Entry
CWACHSRSADVDSLS	ENHO	31	Q6UWT2
FHSDWSSKCSAECGT	ADAMTSL4	846	Q6UY14
HQRLPCCSHLSWSSS	CTC1	76	Q2NKJ3
LSGHWSVHAHCALTC	ATP13A1	116	Q9HD20
SETHCHAERCFLSWF	APOBEC3C	61	Q9NRW3
TSRCWDHHIAEGCFC	GCSAM	31	Q8N6F7
CSGNESFLWDCRHSG	CD163L1	331	Q9NR16
QHAFTRCFHAWSAFC	FLII	1251	Q13045
ALFDSTGTCWAHHRC	KMT2C	241	Q8NEZ4
HGGSCVDLWTHFRCD	CRB2	616	Q5IJ48
HSLHRESSCQGFAWA	EDRF1	781	Q3B7T1
LCSSFSICHTFQWHE	HCAR2	176	Q8TDS4
GFCSRSQHSSSSSHW	ERAP1	496	Q9NZ08
RSCCHLENTWHDHTT	FBXW12	416	Q6X9E4
GITNHTACAHWSGNC	GP2	131	P55259
DHFWSCSCAHSARRR	INSIG1	6	O15503
WTCCLAHGATFLAHS	SLC11A1	516	P49279
THCHAERCFLSWFCD	APOBEC3F	246	Q8IUX4
DRHWHHNCFSCARCS	FHL3	241	Q13643
HSFCRHCLALWWASS	BFAR	51	Q9NZS9
HAGGGQHWESSFSCC	FBXO15	56	Q8NCQ5
QHWESSFSCCSGFLD	FBXO15	61	Q8NCQ5
SGHFRCDSSRWCHDN	FN1	2331	P02751
FSGHTDYRCWTSSHC	INSRR	196	P14616
FTCTHIHSLSPWCAT	ELSPBP1	41	Q96BH3
DAQWSHDFSLCHDCA	KMT2A	1546	Q03164
THCCLEDAWHGGSSL	ENGASE	451	Q8NFI3
CHNGGVCHSRWDDFS	CRB1	896	P82279
RCSGHESYLWSCPHN	DMBT1	801	Q9UGM3
RCSGHESYLWSCPHN	DMBT1	1061	Q9UGM3
SHGWTPLHCAASCND	PPP1R13L	691	Q8WUF5
EHCSWHSPLDRFFSS	DELE1	116	Q14154
ATGCWRAFSTCASHL	OR6B2	231	Q6IFH4
SWIADCARHHCSSTP	OTOG	2781	Q6ZRI0
CTALHWAADGGHCSV	FANK1	211	Q8TC84
WHCHLCPSSTEHASA	PVR	376	P15151
LHASGRFHCSWCWHT	RTP1	86	P59025
IGHCDCTDAQGHSWA	SSPOP	4116	A2VEC9
GHCWGLRSTLASFAC	SCARB1	516	Q8WTV0
ELHHSGWNTCSSCFG	SELENBP1	71	Q13228
ACRHCFTTTSKDWHH	RERE	506	Q9P2R6
RCHCLSSWTGHNCSR	SVEP1	3551	Q4LDE5
QSRCSSWDGCSRSHS	NKAPL	31	Q5M9Q1
CGHSFCHSCLSGLWE	TRIM68	31	Q6AZZ1
VLASCGFSSGRHHWE	TRIM7	386	Q9C029
WRSSFLHHSNRCSCF	TMEM94	51	Q12767
FGHTDWLSDCCFHPS	SPAG16	391	Q8N0X2
SCTWHSCGNFVASSS	SPAG16	441	Q8N0X2
SFCHCERASGHLWSS	SREBF2	941	Q12772
SENTFCSGDHVSWHS	SUFU	151	Q9UMX1
LSAHCASHLAWFGDS	TMEM214	576	Q6NUQ4
EGRCTWGDHCNFSHD	ZC3H4	401	Q9UPT8
AHWLGCSATSTFNFH	SNRNP200	1501	O75643
HFCKCDSVSWLSHHN	ZNF112	206	Q9UJU3
VWDHGGRIFSCSFCH	ZNF330	136	Q9Y3S2
SSWGHHRCQSCITCA	EDA2R	51	Q9HAV5
FHSDWCSPSNCDEIH	SPATA6	366	Q9NWH7
SWTSCDHHESQECKG	ZNF285	186	Q96NJ3
DCSHSFSSRTDLNHW	TNRC6A	1886	Q8NDV7
GNWSHCSATCGHLGA	ADAMTSL3	1431	P82987
EFHCLSGECIHSSWR	LDLR	201	P01130