Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	SOX1 SOX3 MSX1 OTX1 FOXC1 STAT5A	1.92e-04	560	31	6	GO:0001228
GeneOntologyMolecularFunction	transcription coregulator activity	RBM14 MED14 ARID1B MAML3 TLE3 TLE4	1.96e-04	562	31	6	GO:0003712
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	SOX1 SOX3 MSX1 OTX1 FOXC1 STAT5A	2.03e-04	566	31	6	GO:0001216
GeneOntologyMolecularFunction	cyclase activity	TKFC ADCY9	6.30e-04	24	31	2	GO:0009975
GeneOntologyMolecularFunction	phosphorus-oxygen lyase activity	TKFC ADCY9	6.84e-04	25	31	2	GO:0016849
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SOX1 SOX3 MSX1 OTX1 IRX2 DMBX1 FOXC1 STAT5A	1.11e-03	1412	31	8	GO:0000981
GeneOntologyMolecularFunction	transcription coactivator activity	RBM14 MED14 ARID1B MAML3	1.18e-03	303	31	4	GO:0003713
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SOX1 SOX3 MSX1 OTX1 IRX2 DMBX1 FOXC1 STAT5A	1.38e-03	1459	31	8	GO:0000977
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	RBM14 MED14 NUP62 ARID1B MAML3 TLE3 TLE4	1.68e-03	1160	31	7	GO:0030674
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SOX1 SOX3 MSX1 OTX1 IRX2 FOXC1 STAT5A	2.83e-03	1271	31	7	GO:0000987
GeneOntologyMolecularFunction	nuclear receptor coactivator activity	RBM14 MED14	4.03e-03	61	31	2	GO:0030374
GeneOntologyMolecularFunction	molecular adaptor activity	RBM14 MED14 NUP62 ARID1B MAML3 TLE3 TLE4	4.07e-03	1356	31	7	GO:0060090
GeneOntologyMolecularFunction	lyase activity	TKFC SDS ADCY9	4.26e-03	212	31	3	GO:0016829
GeneOntologyMolecularFunction	chromatin binding	CHD3 NUP62 ARID1B TLE4 FOXC1	5.23e-03	739	31	5	GO:0003682
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	RBM14 SOX1 MED14 SOX3 MSX1 XPA OTX1 SSBP4 MAML3 MAP3K1 FOXC1 STAT5A	3.55e-07	1390	31	12	GO:0045944
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	SOX1 SOX3 MSX1 CHD3 IRX2 DMBX1 TLE4 FOXC1	1.24e-04	1053	31	8	GO:0000122
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	SOX1 SOX3 MSX1 CHD3 IRX2 DMBX1 TLE3 TLE4 FOXC1	1.52e-04	1399	31	9	GO:0045892
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	SOX1 SOX3 MSX1 CHD3 IRX2 DMBX1 TLE3 TLE4 FOXC1	1.64e-04	1413	31	9	GO:1902679
GeneOntologyBiologicalProcess	transcription initiation at RNA polymerase II promoter	RBM14 MED14 XPA ARID1B	1.67e-04	186	31	4	GO:0006367
GeneOntologyCellularComponent	transcription regulator complex	RBM14 MED14 MSX1 CHD3 DMBX1 TLE3 TLE4 STAT5A	1.84e-06	596	31	8	GO:0005667
GeneOntologyCellularComponent	nuclear protein-containing complex	MED14 CHD3 XPA NUP62 ARID1B SETD1B COPS6 TLE3 TLE4 STAT5A	1.84e-05	1377	31	10	GO:0140513
GeneOntologyCellularComponent	chromatin	SOX1 SOX3 MSX1 CHD3 ARID1B OTX1 IRX2 DMBX1 FOXC1 STAT5A	3.43e-05	1480	31	10	GO:0000785
GeneOntologyCellularComponent	beta-catenin-TCF complex	TLE3 TLE4	1.64e-04	13	31	2	GO:1990907
GeneOntologyCellularComponent	RNA polymerase II transcription regulator complex	MED14 TLE3 TLE4 STAT5A	6.69e-04	272	31	4	GO:0090575
GeneOntologyCellularComponent	ATPase complex	ATP6V0C CHD3 ARID1B	9.09e-04	129	31	3	GO:1904949
MousePheno	abnormal brain commissure morphology	SOX3 MSX1 ARID1B MSI1 FOXC1	1.25e-05	161	27	5	MP:0002199
MousePheno	abnormal third ventricle morphology	SOX3 MSX1 OTX1 FOXC1	1.43e-05	78	27	4	MP:0000826
MousePheno	abnormal brain ventricle morphology	SOX3 MSX1 ARID1B OTX1 MSI1 FOXC1	1.43e-05	286	27	6	MP:0000822
MousePheno	abnormal nervous system tract morphology	SOX3 MSX1 ARID1B MSI1 FOXC1	2.72e-05	189	27	5	MP:0000778
MousePheno	abnormal brain white matter morphology	SOX3 MSX1 ARID1B MSI1 FOXC1	4.10e-05	206	27	5	MP:0008026
MousePheno	abnormal brain ventricular system morphology	SOX3 MSX1 ARID1B OTX1 MSI1 FOXC1	8.52e-05	393	27	6	MP:0002200
MousePheno	abnormal corpus callosum morphology	SOX3 ARID1B MSI1 FOXC1	1.03e-04	129	27	4	MP:0000780
MousePheno	abnormal dorsal telencephalic commissure morphology	SOX3 ARID1B MSI1 FOXC1	1.13e-04	132	27	4	MP:0008219
MousePheno	abnormal roof plate morphology	MSX1 FOXC1	1.28e-04	9	27	2	MP:0000923
MousePheno	abnormal ciliary process morphology	OTX1 FOXC1	1.28e-04	9	27	2	MP:0014164
MousePheno	abnormal neurocranium morphology	MSX1 OTX1 MSI1 ADCY9 FOXC1	1.45e-04	269	27	5	MP:0000074
Domain	Groucho_enhance	TLE3 TLE4	2.66e-05	5	31	2	IPR009146
Domain	SOXp	SOX1 SOX3	2.66e-05	5	31	2	PF12336
Domain	SOX_fam	SOX1 SOX3	2.66e-05	5	31	2	IPR022097
Domain	Groucho/TLE_N	TLE3 TLE4	2.66e-05	5	31	2	IPR005617
Domain	TLE_N	TLE3 TLE4	2.66e-05	5	31	2	PF03920
Domain	-	SOX1 SOX3 CHD3	1.02e-04	55	31	3	1.10.30.10
Domain	HMG_box_dom	SOX1 SOX3 CHD3	1.69e-04	65	31	3	IPR009071
Domain	Homeobox_CS	MSX1 OTX1 IRX2 DMBX1	2.43e-04	186	31	4	IPR017970
Domain	Homeobox	MSX1 OTX1 IRX2 DMBX1	5.79e-04	234	31	4	PF00046
Domain	HOMEOBOX_1	MSX1 OTX1 IRX2 DMBX1	5.98e-04	236	31	4	PS00027
Domain	HOX	MSX1 OTX1 IRX2 DMBX1	6.08e-04	237	31	4	SM00389
Domain	Homeobox_dom	MSX1 OTX1 IRX2 DMBX1	6.27e-04	239	31	4	IPR001356
Domain	HOMEOBOX_2	MSX1 OTX1 IRX2 DMBX1	6.27e-04	239	31	4	PS50071
Domain	-	MSX1 OTX1 IRX2 DMBX1	1.18e-03	283	31	4	1.10.10.60
Domain	Homeodomain-like	MSX1 OTX1 IRX2 DMBX1	2.11e-03	332	31	4	IPR009057
Domain	HMG_box	SOX1 SOX3	3.49e-03	53	31	2	PF00505
Domain	HMG_BOX_2	SOX1 SOX3	3.62e-03	54	31	2	PS50118
Domain	HMG	SOX1 SOX3	3.62e-03	54	31	2	SM00398
Domain	RRM_1	RBM14 MSI1 SETD1B	4.86e-03	208	31	3	PF00076
Domain	RRM	RBM14 MSI1 SETD1B	5.47e-03	217	31	3	SM00360
Domain	RRM_dom	RBM14 MSI1 SETD1B	6.20e-03	227	31	3	IPR000504
Domain	Prefoldin	TLE3 TLE4	6.34e-03	72	31	2	IPR009053
Domain	RRM	RBM14 MSI1 SETD1B	6.43e-03	230	31	3	PS50102
Domain	Nucleotide-bd_a/b_plait	RBM14 MSI1 SETD1B	8.80e-03	258	31	3	IPR012677
Pathway	REACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX	SOX3 TLE3 TLE4	2.99e-05	32	27	3	MM14975
Pathway	REACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX	SOX3 TLE3 TLE4	6.84e-05	42	27	3	M27272
Pathway	REACTOME_GASTRULATION	SOX1 MSX1 MAML3 FOXC1	9.98e-05	129	27	4	M46433
Pathway	REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	MAML3 TLE3 TLE4	1.02e-04	48	27	3	M611
Pathway	REACTOME_REPRESSION_OF_WNT_TARGET_GENES	TLE3 TLE4	1.57e-04	10	27	2	MM15156
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	SOX1 MED14 MSX1 ATP6V0C CHD3 ARID1B MSI1 IRX2 MAML3 FOXC1	1.89e-04	1432	27	10	M509
Pathway	REACTOME_REPRESSION_OF_WNT_TARGET_GENES	TLE3 TLE4	3.17e-04	14	27	2	M27402
Pathway	REACTOME_SIGNALING_BY_NOTCH1	MAML3 TLE3 TLE4	3.71e-04	74	27	3	M616
Pathway	WP_BMP_SIGNALING_PATHWAY_IN_EYELID_DEVELOPMENT	MAP3K1 FOXC1	6.57e-04	20	27	2	MM15907
Pathway	WP_BMP_SIGNALING_IN_EYELID_DEVELOPMENT	MAP3K1 FOXC1	6.57e-04	20	27	2	M39624
Pathway	WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES	MED14 MAP3K1	7.97e-04	22	27	2	M39773
Pathway	BIOCARTA_GLEEVEC_PATHWAY	MAP3K1 STAT5A	8.72e-04	23	27	2	MM1424
Pathway	BIOCARTA_GLEEVEC_PATHWAY	MAP3K1 STAT5A	8.72e-04	23	27	2	M7897
Pubmed	The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1.	MSX1 TLE3 TLE4	3.58e-08	8	31	3	16002402
Pubmed	Proliferation of murine midbrain neural stem cells depends upon an endogenous sonic hedgehog (Shh) source.	SOX1 SOX3 MSI1	3.58e-08	8	31	3	23776550
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	SOX1 OTX1 IRX2 TLE3 TLE4 FOXC1 STAT5A	7.78e-08	424	31	7	21731673
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	SOX1 SOX3 MSX1 CHD3 OTX1 DMBX1 TLE3 STAT5A	4.03e-07	808	31	8	20412781
Pubmed	TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration.	SOX1 SOX3 MSX1	4.32e-07	17	31	3	35950911
Pubmed	Transcriptional regulation of cortical neuron migration by POU domain factors.	OTX1 TLE3 TLE4	7.23e-07	20	31	3	11859196
Pubmed	Gro/TLE enables embryonic stem cell differentiation by repressing pluripotent gene expression.	TLE3 TLE4	7.69e-07	2	31	2	25446531
Pubmed	TLE3 and TLE4-coordinated colonic macrophage-CD4+ T cell crosstalk maintains intestinal immune homeostasis.	TLE3 TLE4	7.69e-07	2	31	2	36801171
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	CHD3 ARID1B TLE3 FOXC1	9.03e-07	83	31	4	28794006
Pubmed	A census of human transcription factors: function, expression and evolution.	SOX1 SOX3 MSX1 OTX1 IRX2 DMBX1 FOXC1 STAT5A	9.69e-07	908	31	8	19274049
Pubmed	Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization.	MSX1 OTX1 DMBX1	1.28e-06	24	31	3	20816794
Pubmed	Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.	SOX1 SOX3 OTX1	1.64e-06	26	31	3	22992956
Pubmed	Distinct SoxB1 networks are required for naïve and primed pluripotency.	SOX1 SOX3	2.31e-06	3	31	2	29256862
Pubmed	CSN6 positively regulates c-Jun in a MEKK1-dependent manner.	COPS6 MAP3K1	2.31e-06	3	31	2	26237449
Pubmed	Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD.	SOX1 MAML3	2.31e-06	3	31	2	25234806
Pubmed	Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity.	TLE3 TLE4	2.31e-06	3	31	2	30045946
Pubmed	Identification, tissue expression, and functional characterization of Otx3, a novel member of the Otx family.	OTX1 DMBX1	2.31e-06	3	31	2	12055180
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	RBM14 NUP62 ARID1B TKFC MAML3 TLE3	2.78e-06	457	31	6	32344865
Pubmed	Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo.	SOX1 MSX1 NUP62	3.77e-06	34	31	3	18539113
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	MED14 CHD3 ARID1B TLE3 TLE4	3.77e-06	268	31	5	33640491
Pubmed	Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube.	TLE3 TLE4	4.61e-06	4	31	2	11290324
Pubmed	TLE expression correlates with mouse embryonic segmentation, neurogenesis, and epithelial determination.	TLE3 TLE4	4.61e-06	4	31	2	8645603
Pubmed	Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages.	SOX1 SOX3	4.61e-06	4	31	2	10446282
Pubmed	Sox1 maintains the undifferentiated state of cortical neural progenitor cells via the suppression of Prox1-mediated cell cycle exit and neurogenesis.	SOX1 MSI1	4.61e-06	4	31	2	21280160
Pubmed	Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.	OTX1 TLE4	7.68e-06	5	31	2	12652306
Pubmed	Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins.	TLE3 TLE4	7.68e-06	5	31	2	1303260
Pubmed	Grg3, a murine Groucho-related gene, is expressed in the developing nervous system and in mesenchyme-induced epithelial structures.	TLE3 TLE4	7.68e-06	5	31	2	8989517
Pubmed	The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-potentiated insulin secretion.	SOX1 MSI1	7.68e-06	5	31	2	22975310
Pubmed	Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.	TLE3 TLE4	7.68e-06	5	31	2	8365415
Pubmed	A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes.	SOX1 SOX3	7.68e-06	5	31	2	2374589
Pubmed	Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors.	SOX1 OTX1 TLE4	8.87e-06	45	31	3	22696295
Pubmed	Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development.	TLE3 TLE4	1.15e-05	6	31	2	8892234
Pubmed	Evolution of the Sry genes.	SOX3 MSX1	1.15e-05	6	31	2	9000753
Pubmed	Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex.	TLE3 TLE4	1.15e-05	6	31	2	8573724
Pubmed	Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells.	SOX1 SOX3	1.61e-05	7	31	2	15456859
Pubmed	BMP signaling is required for development of the ciliary body.	MSX1 OTX1	1.61e-05	7	31	2	12223402
Pubmed	A Gro/TLE-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression.	TLE3 TLE4	1.61e-05	7	31	2	24024827
Pubmed	Evidence that the SRY protein is encoded by a single exon on the human Y chromosome.	SOX1 SOX3	1.61e-05	7	31	2	8244390
Pubmed	Pairing SOX off: with partners in the regulation of embryonic development.	SOX1 SOX3	1.61e-05	7	31	2	10729834
Pubmed	A comparison of Notch, Hes and Grg expression during murine embryonic and post-natal development.	TLE3 TLE4	2.15e-05	8	31	2	10512199
Pubmed	Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: implications for co-operative versus non-co-operative actions of Mdm20 and Nat5.	SOX1 SOX3	2.15e-05	8	31	2	22101279
Pubmed	Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling.	TLE3 TLE4	2.15e-05	8	31	2	20735826
Pubmed	Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.	TLE3 TLE4	2.15e-05	8	31	2	28296634
Pubmed	Functional Equivalence of the SOX2 and SOX3 Transcription Factors in the Developing Mouse Brain and Testes.	SOX1 SOX3	2.15e-05	8	31	2	28515211
Pubmed	Human transcription factor protein interaction networks.	CHD3 NUP62 ARID1B SSBP4 TLE3 TLE4 FOXC1 STAT5A	2.70e-05	1429	31	8	35140242
Pubmed	Genetic aspects of embryonic eye development in vertebrates.	MSX1 OTX1	2.76e-05	9	31	2	8631154
Pubmed	Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear.	MSX1 OTX1	2.76e-05	9	31	2	17395647
Pubmed	Sox2 requirement in sonic hedgehog-associated medulloblastoma.	SOX1 SOX3	2.76e-05	9	31	2	23596255
Pubmed	Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome.	SOX3 MSX1	2.76e-05	9	31	2	12522767
Pubmed	Sox2 induces neuronal formation in the developing mammalian cochlea.	SOX1 SOX3	2.76e-05	9	31	2	20071536
Pubmed	Congenital hydrocephalus and abnormal subcommissural organ development in Sox3 transgenic mice.	SOX3 MSX1	2.76e-05	9	31	2	22291885
Pubmed	Inhibition of mouse GPM6A expression leads to decreased differentiation of neurons derived from mouse embryonic stem cells.	SOX1 OTX1	2.76e-05	9	31	2	18522499
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	OTX1 COPS6 IRX2 DMBX1 MAML3 STAT5A	3.35e-05	709	31	6	22988430
Pubmed	Crumbs2 mediates ventricular layer remodelling to form the spinal cord central canal.	SOX1 SOX3	3.44e-05	10	31	2	32150534
Pubmed	From head to toes: the multiple facets of Sox proteins.	SOX1 SOX3	3.44e-05	10	31	2	10037800
Pubmed	Spatial distribution of the full-length members of the Grg family during embryonic neurogenesis reveals a "Grg-mediated repression map" in the mouse telencephalon.	TLE3 TLE4	3.44e-05	10	31	2	30571765
Pubmed	Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2.	OTX1 DMBX1	3.44e-05	10	31	2	11731459
Pubmed	Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles.	MSX1 OTX1	3.44e-05	10	31	2	11955708
Pubmed	Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells.	SOX1 MSX1	3.44e-05	10	31	2	30581079
Pubmed	Coexpression of Cux-1 and Notch signaling pathway components during kidney development.	TLE3 TLE4	4.21e-05	11	31	2	15499562
Pubmed	Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool.	TLE3 TLE4	4.21e-05	11	31	2	28800615
Pubmed	Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4.	MSX1 FOXC1	4.21e-05	11	31	2	14512019
Pubmed	Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.	RBM14 ARID1B TLE3	4.66e-05	78	31	3	28611094
Pubmed	Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1.	SOX1 SOX3	5.05e-05	12	31	2	15882093
Pubmed	Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators.	SOX1 SOX3	5.05e-05	12	31	2	11071752
Pubmed	Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during gonadotrope development.	MSX1 TLE4	5.05e-05	12	31	2	23371388
Pubmed	Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors.	SOX1 SOX3	5.05e-05	12	31	2	27246266
Pubmed	All Tcf HMG box transcription factors interact with Groucho-related co-repressors.	TLE3 TLE4	5.05e-05	12	31	2	11266540
Pubmed	Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4.	MSX1 OTX1	5.96e-05	13	31	2	21856951
Pubmed	A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2.	SOX1 SOX3	5.96e-05	13	31	2	8625802
Pubmed	Neurog2 simultaneously activates and represses alternative gene expression programs in the developing neocortex.	TLE3 TLE4	5.96e-05	13	31	2	22735158
Pubmed	Molecular markers of cardiac endocardial cushion development.	MSX1 FOXC1	5.96e-05	13	31	2	14648841
Pubmed	Seven new members of the Sox gene family expressed during mouse development.	SOX1 SOX3	5.96e-05	13	31	2	8441686
Pubmed	Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.	SOX1 SOX3	5.96e-05	13	31	2	12194848
Pubmed	Cortical and Clonal Contribution of Tbr2 Expressing Progenitors in the Developing Mouse Brain.	SOX1 OTX1	5.96e-05	13	31	2	24927931
Pubmed	Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells In vitro.	SOX1 SOX3	6.95e-05	14	31	2	21766338
Pubmed	Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis.	MSI1 TLE4	6.95e-05	14	31	2	15273690
Pubmed	Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.	TLE3 TLE4	6.95e-05	14	31	2	17202186
Pubmed	Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway.	TLE3 TLE4	8.02e-05	15	31	2	9291577
Pubmed	Expression of the Ladybird-like homeobox 2 transcription factor in the developing mouse testis and epididymis.	MSX1 DMBX1	8.02e-05	15	31	2	18304314
Pubmed	Dlx5-augmentation in neural crest cells reveals early development and differentiation potential of mouse apical head mesenchyme.	MSX1 FOXC1	8.02e-05	15	31	2	33483579
Pubmed	Canonical Wnt signaling modulates Tbx1, Eya1, and Six1 expression, restricting neurogenesis in the otic vesicle.	MSX1 OTX1	8.02e-05	15	31	2	20503367
Pubmed	GATA3 is essential for separating patterning domains during facial morphogenesis.	MSX1 FOXC1	8.02e-05	15	31	2	34383890
Pubmed	Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord.	SOX1 SOX3	8.02e-05	15	31	2	15893981
Pubmed	Foxg1 is required to limit the formation of ciliary margin tissue and Wnt/β-catenin signalling in the developing nasal retina of the mouse.	MSX1 OTX1	8.02e-05	15	31	2	23624311
Pubmed	Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells.	SOX1 SOX3	8.02e-05	15	31	2	21331042
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	MSX1 OTX1 IRX2 DMBX1	8.56e-05	263	31	4	20932939
Pubmed	Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes.	SOX1 SOX3	9.16e-05	16	31	2	24257626
Pubmed	STAT5A/B activity is required in the developing forebrain and spinal cord.	OTX1 STAT5A	9.16e-05	16	31	2	17462911
Pubmed	Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages.	SOX1 SOX3	9.16e-05	16	31	2	17699610
Pubmed	Delayed fusion and altered gene expression contribute to semicircular canal defects in Chd7 deficient mice.	MSX1 OTX1	9.16e-05	16	31	2	22705977
Pubmed	Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis.	MSX1 OTX1	9.16e-05	16	31	2	19122665
Pubmed	Sox2 is required for embryonic development of the ventral telencephalon through the activation of the ventral determinants Nkx2.1 and Shh.	SOX1 SOX3	1.04e-04	17	31	2	23444355
Pubmed	Spatio-temporal expression of Sox genes in murine palatogenesis.	SOX1 SOX3	1.04e-04	17	31	2	27241892
Pubmed	Establishment of the neurogenic boundary of the mouse retina requires cooperation of SOX2 and WNT signaling.	MSX1 OTX1	1.04e-04	17	31	2	25488119
Pubmed	Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus.	MSX1 OTX1	1.04e-04	17	31	2	16900517
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	SOX3 MSX1 XPA OTX1 DMBX1	1.12e-04	544	31	5	28473536
Pubmed	Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.	MED14 ATP6V0C NUP62 SETD1B	1.14e-04	283	31	4	18854154
Pubmed	Groucho co-repressor proteins regulate β cell development and proliferation by repressing Foxa1 in the developing mouse pancreas.	TLE3 TLE4	1.17e-04	18	31	2	33658226
Pubmed	Expression of Sox genes in tooth development.	SOX1 SOX3	1.17e-04	18	31	2	26864488
Interaction	TLE4 interactions	MSX1 NUP62 OTX1 TLE3 TLE4	2.31e-07	92	30	5	int:TLE4
Interaction	FOXI1 interactions	ARID1B COPS6 TLE3 TLE4 FOXC1	2.31e-07	92	30	5	int:FOXI1
Interaction	PAX7 interactions	ARID1B SSBP4 TLE3 TLE4 FOXC1	1.02e-06	124	30	5	int:PAX7
Interaction	PAX9 interactions	MSX1 ARID1B TLE3 TLE4 FOXC1	1.29e-06	130	30	5	int:PAX9
Interaction	PAX6 interactions	SOX3 CHD3 ARID1B TLE3 TLE4 FOXC1	1.41e-05	366	30	6	int:PAX6
Interaction	TLE3 interactions	RBM14 ARID1B SSBP4 TLE3 TLE4 FOXC1	1.65e-05	376	30	6	int:TLE3
Interaction	TBXT interactions	ARID1B TLE3 TLE4 FOXC1	2.54e-05	116	30	4	int:TBXT
Interaction	NUP35 interactions	RBM14 NUP62 ARID1B TKFC MAML3 TLE3	3.24e-05	424	30	6	int:NUP35
Interaction	SMARCE1 interactions	RBM14 CHD3 NUP62 ARID1B FOXC1	6.02e-05	287	30	5	int:SMARCE1
Interaction	NR3C1 interactions	RBM14 MED14 NUP62 ARID1B COPS6 MAML3 TLE3 STAT5A	6.54e-05	974	30	8	int:NR3C1
Interaction	SP7 interactions	CHD3 ARID1B TLE3 TLE4 FOXC1	7.90e-05	304	30	5	int:SP7
Interaction	SSBP4 interactions	RBM14 SSBP4 TLE3	9.15e-05	59	30	3	int:SSBP4
Interaction	SIX6 interactions	TLE3 TLE4	1.17e-04	11	30	2	int:SIX6
Interaction	TLX1 interactions	ARID1B TLE3 TLE4 FOXC1	1.26e-04	175	30	4	int:TLX1
Interaction	POU2F1 interactions	MSX1 TLE4 FOXC1 STAT5A	1.26e-04	175	30	4	int:POU2F1
Interaction	TEAD1 interactions	CHD3 ARID1B TLE3 FOXC1	1.29e-04	176	30	4	int:TEAD1
Interaction	EP300 interactions	RBM14 NADK CHD3 XPA SSBP4 COPS6 TLE3 FOXC1 STAT5A	1.39e-04	1401	30	9	int:EP300
Interaction	SMARCC2 interactions	RBM14 CHD3 ARID1B TLE3 FOXC1	1.59e-04	353	30	5	int:SMARCC2
Interaction	GATA2 interactions	ARID1B TLE3 TLE4 FOXC1	2.07e-04	199	30	4	int:GATA2
Interaction	CUX1 interactions	CHD3 NUP62 TLE3 TLE4	2.07e-04	199	30	4	int:CUX1
Interaction	FEV interactions	ARID1B TLE3 TLE4 FOXC1	2.23e-04	203	30	4	int:FEV
Interaction	SOX7 interactions	RBM14 ARID1B TLE3	2.44e-04	82	30	3	int:SOX7
Interaction	NFIC interactions	SOX3 ARID1B TLE3 FOXC1	2.54e-04	210	30	4	int:NFIC
Interaction	QPRT interactions	ARID1B TLE3 TLE4	2.61e-04	84	30	3	int:QPRT
Interaction	NUP43 interactions	RBM14 CHD3 XPA NUP62 ARID1B SETD1B	2.73e-04	625	30	6	int:NUP43
Interaction	C4orf17 interactions	CHD3 COPS6	2.87e-04	17	30	2	int:C4orf17
Interaction	GSC interactions	ARID1B TLE3 TLE4	2.90e-04	87	30	3	int:GSC
Interaction	PBX2 interactions	NUP62 COPS6 FOXC1	3.99e-04	97	30	3	int:PBX2
Interaction	SIX3 interactions	TLE3 TLE4	4.00e-04	20	30	2	int:SIX3
Interaction	RIPPLY2 interactions	TLE3 TLE4	4.00e-04	20	30	2	int:RIPPLY2
Interaction	TBX20 interactions	TLE3 TLE4	4.42e-04	21	30	2	int:TBX20
Interaction	SALL1 interactions	CHD3 TLE3 FOXC1	4.63e-04	102	30	3	int:SALL1
Interaction	STAT3 interactions	NUP62 ARID1B MAP3K1 FOXC1 STAT5A	4.68e-04	446	30	5	int:STAT3
Interaction	CBFB interactions	RBM14 TLE3 FOXC1	4.90e-04	104	30	3	int:CBFB
Interaction	ETV6 interactions	NUP62 TLE3 FOXC1	5.04e-04	105	30	3	int:ETV6
Interaction	AR interactions	RBM14 MED14 CHD3 ARID1B TKFC TLE3 TLE4	5.15e-04	992	30	7	int:AR
Interaction	CPSF1 interactions	RBM14 CHD3 ARID1B COPS6	5.30e-04	255	30	4	int:CPSF1
Interaction	SMARCA4 interactions	CHD3 ARID1B TLE3 FOXC1 STAT5A	5.50e-04	462	30	5	int:SMARCA4
Interaction	ZFHX3 interactions	CHD3 COPS6 TLE3	5.62e-04	109	30	3	int:ZFHX3
Interaction	EN1 interactions	TLE3 TLE4 FOXC1	5.77e-04	110	30	3	int:EN1
Interaction	HOXC13 interactions	TLE3 FOXC1	5.79e-04	24	30	2	int:HOXC13
Interaction	PAX8 interactions	ARID1B TLE3 TLE4	5.92e-04	111	30	3	int:PAX8
Interaction	TBR1 interactions	ARID1B TLE3 TLE4	6.24e-04	113	30	3	int:TBR1
Interaction	MEN1 interactions	RBM14 MED14 CHD3 ARID1B SETD1B TLE3 FOXC1	6.41e-04	1029	30	7	int:MEN1
Interaction	LDB1 interactions	SSBP4 TLE3 FOXC1	6.57e-04	115	30	3	int:LDB1
Interaction	HNF4A interactions	MED14 CHD3 ARID1B FOXC1	7.03e-04	275	30	4	int:HNF4A
Interaction	ARID1A interactions	CHD3 ARID1B TLE3 FOXC1	7.13e-04	276	30	4	int:ARID1A
GeneFamily	SRY-boxes	SOX1 SOX3	2.61e-04	19	23	2	757
GeneFamily	RNA binding motif containing	RBM14 MSI1 SETD1B	2.40e-03	213	23	3	725
GeneFamily	PRD class homeoboxes and pseudogenes	OTX1 DMBX1	6.04e-03	92	23	2	521
Coexpression	TESAR_ALK_TARGETS_HUMAN_ES_5D_UP	SOX1 MSX1	1.35e-05	5	31	2	M19304
Coexpression	TESAR_ALK_TARGETS_EPISC_3D_UP	SOX1 MSX1	2.83e-05	7	31	2	M1761
Coexpression	TESAR_ALK_TARGETS_EPISC_3D_UP	SOX1 MSX1	2.83e-05	7	31	2	MM1222
Coexpression	DAWSON_METHYLATED_IN_LYMPHOMA_TCL1	SOX1 SOX3 FOXC1	4.66e-05	59	31	3	M1238
Coexpression	DAWSON_METHYLATED_IN_LYMPHOMA_TCL1	SOX1 SOX3 FOXC1	4.66e-05	59	31	3	MM528
Coexpression	GSE43955_TH0_VS_TGFB_IL6_IL23_TH17_ACT_CD4_TCELL_60H_DN	SSBP4 TLE3 MAP3K1 STAT5A	8.81e-05	200	31	4	M9688
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-NK_CD56bright\|ICU-NoSEP / Disease, Lineage and Cell Type	MED14 ATP6V0C ADCY9 FOXC1	5.33e-06	167	31	4	f4f188a8efca8cdd0ecfb857fe4538c10847eadd
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_FOS\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MSX1 OTX1 MSI1 SDS	7.81e-06	184	31	4	22c18964818fc9c8f18051f836d718937b0d8d12
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_4\|COVID-19_Mild / Disease condition and Cell class	FOLR3 TLE3 TLE4 MAP3K1	1.00e-05	196	31	4	3729d1444c65cad640377894decc64129bc3fd5b
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-NK_CD56bright\|ICU-NoSEP / Disease, condition lineage and cell class	MED14 ATP6V0C ADCY9 FOXC1	1.09e-05	200	31	4	c2df917900872453ea17a39928e39d071a6d3339
Drug	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine	ATP6V0C SDS MAP3K1	5.17e-05	55	30	3	ctd:C473484
Drug	Ro 65-7199	ATP6V0C SDS MAP3K1	5.17e-05	55	30	3	ctd:C488333
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A	NUP62 SETD1B TLE3 FOXC1	6.91e-05	169	30	4	5231_DN
Drug	glycine	SOX1 MED14 TKFC SDS	6.91e-05	169	30	4	CID000000750
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A_EA	NUP62 SETD1B TLE3 FOXC1	7.91e-05	175	30	4	1014_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A	NUP62 SETD1B ADCY9 FOXC1	7.91e-05	175	30	4	6891_DN
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A_EA	RBM14 TLE3 ADCY9 FOXC1	1.04e-04	188	30	4	986_DN
Drug	Gallamine triethiodide [65-29-2]; Down 200; 4.4uM; MCF7; HT_HG-U133A	MED14 TKFC TLE3 TLE4	1.15e-04	193	30	4	6215_DN
Drug	Protriptyline hydrochloride [1225-55-4]; Down 200; 13.4uM; HL60; HT_HG-U133A	MED14 NADK NUP62 MAP3K1	1.20e-04	195	30	4	3119_DN
Drug	Clomiphene citrate (Z,E) [50-41-9]; Down 200; 6.6uM; MCF7; HT_HG-U133A	TLE3 ADCY9 MAP3K1 FOXC1	1.20e-04	195	30	4	4994_DN
Drug	Acetazolamide [59-66-5]; Down 200; 18uM; MCF7; HT_HG-U133A	CHD3 TKFC SETD1B ADCY9	1.22e-04	196	30	4	1686_DN
Drug	Bacitracin [1405-87-4]; Down 200; 2.8uM; MCF7; HT_HG-U133A	SOX3 XPA ADCY9 FOXC1	1.22e-04	196	30	4	7448_DN
Drug	LY 294002; Down 200; 10uM; MCF7; HT_HG-U133A	MED14 CHD3 ADCY9 MAP3K1	1.25e-04	197	30	4	5236_DN
Drug	rottlerin; Down 200; 10uM; MCF7; HT_HG-U133A_EA	NADK TLE3 TLE4 FOXC1	1.25e-04	197	30	4	825_DN
Drug	Tomatidine [77-59-8]; Up 200; 9.6uM; HL60; HG-U133A	RBM14 NADK NUP62 ADCY9	1.27e-04	198	30	4	1754_UP
Drug	Hippeastrine hydrobromide [22352-41-6]; Down 200; 10uM; MCF7; HT_HG-U133A	MED14 MSI1 MAP3K1 FOXC1	1.27e-04	198	30	4	6042_DN
Drug	Bemegride [64-65-3]; Down 200; 25.8uM; MCF7; HT_HG-U133A	NADK CHD3 MSI1 MAP3K1	1.30e-04	199	30	4	5014_DN
Drug	Methapyrilene hydrochloride [135-23-9]; Down 200; 13.4uM; HL60; HG-U133A	MED14 CHD3 TLE3 ADCY9	1.30e-04	199	30	4	1588_DN
Drug	Adiphenine hydrochloride [50-42-0]; Down 200; 11.4uM; PC3; HT_HG-U133A	NADK XPA SETD1B FOXC1	1.30e-04	199	30	4	7279_DN
Drug	Betulin [473-98-3]; Down 200; 9uM; MCF7; HT_HG-U133A	NADK MSX1 ADCY9 MAP3K1	1.30e-04	199	30	4	7454_DN
Drug	Benzathine benzylpenicillin [5928-84-7]; Down 200; 4.2uM; HL60; HT_HG-U133A	MED14 NADK TLE3 ADCY9	1.32e-04	200	30	4	2939_DN
Drug	hilE	XPA TKFC SDS	1.36e-04	76	30	3	CID000000791
Disease	blood manganese measurement	TLE3 ADCY9	3.22e-04	27	29	2	EFO_0007581
Disease	Malignant neoplasm of breast	MED14 ARID1B MSI1 TLE3 MAP3K1 STAT5A	5.31e-04	1074	29	6	C0006142
Disease	C-reactive protein measurement	SSBP4 MAML3 ADCY9 TLE4 MAP3K1 FAM177A1	9.74e-04	1206	29	6	EFO_0004458
Disease	irritable bowel syndrome symptom measurement	ARID1B TLE3	1.49e-03	58	29	2	EFO_0021536
Disease	Breast Carcinoma	ARID1B TLE3 MAP3K1 STAT5A	1.81e-03	538	29	4	C0678222
Disease	estrogen-receptor negative breast cancer	ADCY9 MAP3K1	2.22e-03	71	29	2	EFO_1000650
Disease	calcium measurement	ARID1B FOLR3 TLE3 TLE4	3.16e-03	628	29	4	EFO_0004838

Protein segments in the cluster

Peptide	Gene	Start	Entry
MAAAAAAAAATNGTG	COPS6	1	Q7L5N1
DMGAQYAAASPAWAA	ARID1B	561	Q8NFD5
PAAYAAQATTPMAGS	RBM14	446	Q96PK6
AGQPSAAYLSMSQGA	RBM14	551	Q96PK6
MGDFAAPAAAANGSS	MAML3	1	Q96JK9
AAAAAFGESAGQMSN	FAM177A1	21	Q8N128
PTGSTAYAAAAGASM	NADK	321	O95544
AYAAAAGASMIHPNV	NADK	326	O95544
AVLRASYGQSAAMPA	PCYOX1L	211	Q8NBM8
AKFYAAAMNAGAPSR	FOLR3	226	P41439
PGAAAGAAASSAMTY	NUP62	316	P37198
PLTAYGPMAAAAAAA	MSI1	266	O43347
DAAAAAAGFPSYMGA	IRX2	71	Q9BZI1
AAGAATAAASYPMSY	OTX1	211	P32242
AVAAAAAAAASPGYR	MED14	36	O60244
ASAAAAAAAAGYPGQ	FOXC1	486	Q12948
GALAAAGANYSQMPA	CHD3	1941	Q12873
AAAAAAVPYLGVNMA	DMBX1	296	Q8NFW5
GATYMAASGLNTAQA	ADCY9	1111	O60503
VCSSAGNAGMAAAYA	SDS	61	P20132
MAAAAGNRASSSGFP	MAP3K1	1	Q13233
GAQSYMNVAAAAAAA	SOX3	316	P41225
MNVAAAAAAASGYGG	SOX3	321	P41225
MAPSATAAAAAAYGQ	SOX3	336	P41225
AAYGQQPATAAAAAA	SOX3	346	P41225
QAPSAAAATAAAMGA	MSX1	31	P28360
PFMAAAAAAASAGLQ	SETD1B	796	Q9UPS6
AYPGSVAAAAAAAAM	SOX1	191	O00570
ADAGGSSATYMDQAP	STAT5A	711	P42229
AAMVFSALGAAYGTA	ATP6V0C	21	P27449
AAAAAAAAAAYGRSP	TLE4	406	Q04727
QDYSAAAAPSPVMGS	SSBP4	91	Q9BWG4
PPQMSAAAAAAAAAY	TLE3	396	Q04726
AAAAAAAAAYGRSPM	TLE3	401	Q04726
AAAAYGRSPMVSFGA	TLE3	406	Q04726
RPYSATAAAATGGMA	XPA	46	P23025
NMEAGAGRASYISSA	TKFC	536	Q3LXA3
AAGSAAGLYPSARSM	PRR23C	171	Q6ZRP0