Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity	MYO3A SMCHD1 KIF1B SMARCA1 KIF28P MCM7 DHX32 ATP11A DDX20 RUVBL2 TOP2B DYNC1I1 KIF1C	2.80e-06	614	88	13	GO:0140657
GeneOntologyMolecularFunction	structural constituent of muscle	NEBL OBSCN PLEC NEB	3.81e-05	43	88	4	GO:0008307
GeneOntologyMolecularFunction	ATP hydrolysis activity	SMCHD1 KIF1B KIF28P MCM7 DHX32 ATP11A DDX20 RUVBL2 KIF1C	1.41e-04	441	88	9	GO:0016887
GeneOntologyMolecularFunction	phospholipid binding	RASA4 PCLO UCP1 OBSCN RASA4B SDCBP2 GSN ARAP2 RPS6KC1 ITPR3	1.48e-04	548	88	10	GO:0005543
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYO3A KIF1B KIF28P DYNC1I1 KIF1C	1.75e-04	118	88	5	GO:0003774
GeneOntologyMolecularFunction	MHC class II protein complex binding	HLA-DRB1 HLA-DRB4 HLA-DRB5	2.24e-04	27	88	3	GO:0023026
GeneOntologyMolecularFunction	microtubule motor activity	KIF1B KIF28P DYNC1I1 KIF1C	2.59e-04	70	88	4	GO:0003777
GeneOntologyMolecularFunction	actin filament binding	MYO3A NEBL PLEC NEB FMNL1 GSN	5.04e-04	227	88	6	GO:0051015
GeneOntologyMolecularFunction	helicase activity	SMARCA1 MCM7 DHX32 DDX20 RUVBL2	6.72e-04	158	88	5	GO:0004386
GeneOntologyMolecularFunction	MHC protein complex binding	HLA-DRB1 HLA-DRB4 HLA-DRB5	7.81e-04	41	88	3	GO:0023023
GeneOntologyMolecularFunction	CD4 receptor binding	HLA-DRB1 HLA-DRB5	1.03e-03	11	88	2	GO:0042609
GeneOntologyMolecularFunction	MHC class II receptor activity	HLA-DRB1 HLA-DRB5	1.03e-03	11	88	2	GO:0032395
GeneOntologyMolecularFunction	peptide antigen binding	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.32e-03	49	88	3	GO:0042605
GeneOntologyMolecularFunction	profilin binding	PCLO FMNL1	1.45e-03	13	88	2	GO:0005522
GeneOntologyMolecularFunction	myosin II binding	LIMCH1 GSN	1.45e-03	13	88	2	GO:0045159
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DOCK8 RASA4 OBSCN DENND6B RASA4B HMGCR DENND3 ARAP2	1.78e-03	507	88	8	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DOCK8 RASA4 OBSCN DENND6B RASA4B HMGCR DENND3 ARAP2	1.78e-03	507	88	8	GO:0030695
GeneOntologyBiologicalProcess	MHC class II protein complex assembly	HLA-DRB1 HLA-DRB4 HLA-DRB5	3.77e-05	16	86	3	GO:0002399
GeneOntologyBiologicalProcess	peptide antigen assembly with MHC class II protein complex	HLA-DRB1 HLA-DRB4 HLA-DRB5	3.77e-05	16	86	3	GO:0002503
GeneOntologyBiologicalProcess	cardiac muscle thin filament assembly	NEBL NEB	5.14e-05	3	86	2	GO:0071691
GeneOntologyBiologicalProcess	MHC protein complex assembly	HLA-DRB1 HLA-DRB4 HLA-DRB5	8.82e-05	21	86	3	GO:0002396
GeneOntologyBiologicalProcess	peptide antigen assembly with MHC protein complex	HLA-DRB1 HLA-DRB4 HLA-DRB5	8.82e-05	21	86	3	GO:0002501
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	NPTN FAT1 PCDHAC1 CDH23 CDH10 PTK7	1.32e-04	187	86	6	GO:0007156
GeneOntologyCellularComponent	MHC class II protein complex	HLA-DRB1 HLA-DRB4 HLA-DRB5	4.70e-05	17	88	3	GO:0042613
GeneOntologyCellularComponent	immunological synapse	NPTN HLA-DRB1 HLA-DRB5 SOCS6	5.38e-05	49	88	4	GO:0001772
GeneOntologyCellularComponent	MHC protein complex	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.75e-04	26	88	3	GO:0042611
GeneOntologyCellularComponent	lumenal side of endoplasmic reticulum membrane	HLA-DRB1 HLA-DRB4 HLA-DRB5	4.28e-04	35	88	3	GO:0098553
GeneOntologyCellularComponent	endoplasmic reticulum membrane	DHRS3 TMEM98 VPS13C HLA-DRB1 HLA-DRB4 HLA-DRB5 NUP210 VPS13A ATP11A EXT2 HMGCR LBR MAP3K5 ITPR3	9.72e-04	1293	88	14	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	DHRS3 TMEM98 VPS13C HLA-DRB1 HLA-DRB4 HLA-DRB5 NUP210 VPS13A ATP11A EXT2 HMGCR LBR MAP3K5 ITPR3	1.02e-03	1299	88	14	GO:0098827
GeneOntologyCellularComponent	lumenal side of membrane	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.09e-03	48	88	3	GO:0098576
GeneOntologyCellularComponent	nucleocytoplasmic transport complex	XPO5 KPNA6	1.13e-03	12	88	2	GO:0031074
GeneOntologyCellularComponent	kinesin complex	KIF1B KIF28P KIF1C	1.15e-03	49	88	3	GO:0005871
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	DHRS3 TMEM98 VPS13C HLA-DRB1 HLA-DRB4 HLA-DRB5 NUP210 VPS13A ATP11A EXT2 HMGCR LBR MAP3K5 ITPR3	1.25e-03	1327	88	14	GO:0042175
Domain	MHC_II_b_N	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.56e-06	8	88	3	PD000328
Domain	MHC_II_beta	HLA-DRB1 HLA-DRB4 HLA-DRB5	8.32e-06	9	88	3	PF00969
Domain	MHC_II_b_N	HLA-DRB1 HLA-DRB4 HLA-DRB5	8.32e-06	9	88	3	IPR000353
Domain	MHC_II_beta	HLA-DRB1 HLA-DRB4 HLA-DRB5	8.32e-06	9	88	3	SM00921
Domain	MHC_II_a/b_N	HLA-DRB1 HLA-DRB4 HLA-DRB5	3.54e-05	14	88	3	IPR014745
Domain	-	HLA-DRB1 HLA-DRB4 HLA-DRB5	3.54e-05	14	88	3	3.10.320.10
Domain	VPS13	VPS13C VPS13A	6.56e-05	3	88	2	IPR026847
Domain	VPS13_mid_rpt	VPS13C VPS13A	6.56e-05	3	88	2	PF16910
Domain	VPS13	VPS13C VPS13A	6.56e-05	3	88	2	PF16908
Domain	-	RASA4 RASA4B	6.56e-05	3	88	2	4.10.1130.10
Domain	VPS13_N2	VPS13C VPS13A	6.56e-05	3	88	2	IPR031646
Domain	VPS13_mid_rpt	VPS13C VPS13A	6.56e-05	3	88	2	IPR031642
Domain	IG_LIKE	NPTN IGSF22 NTM HLA-DRB1 HLA-DRB4 HLA-DRB5 OBSCN FCRLB IL1R1 PTK7	1.04e-04	491	88	10	PS50835
Domain	Ig-like_dom	NPTN IGSF22 NTM HLA-DRB1 HLA-DRB4 HLA-DRB5 OBSCN FCRLB IL1R1 PTK7	1.26e-04	503	88	10	IPR007110
Domain	NEBU	NEBL NEB	1.31e-04	4	88	2	SM00227
Domain	Nebulin	NEBL NEB	1.31e-04	4	88	2	PF00880
Domain	Nebulin	NEBL NEB	1.31e-04	4	88	2	IPR013998
Domain	VPS13_C	VPS13C VPS13A	1.31e-04	4	88	2	PF16909
Domain	SHR-BD	VPS13C VPS13A	1.31e-04	4	88	2	IPR009543
Domain	NEBULIN	NEBL NEB	1.31e-04	4	88	2	PS51216
Domain	VPS13_C	VPS13C VPS13A	1.31e-04	4	88	2	IPR031645
Domain	Nebulin_repeat	NEBL NEB	1.31e-04	4	88	2	IPR000900
Domain	SHR-BD	VPS13C VPS13A	1.31e-04	4	88	2	PF06650
Domain	ATG_C	VPS13C VPS13A	2.17e-04	5	88	2	PF09333
Domain	Autophagy-rel_C	VPS13C VPS13A	2.17e-04	5	88	2	IPR015412
Domain	Ig_I-set	NPTN IGSF22 NTM OBSCN IL1R1 PTK7	2.78e-04	190	88	6	IPR013098
Domain	I-set	NPTN IGSF22 NTM OBSCN IL1R1 PTK7	2.78e-04	190	88	6	PF07679
Domain	Kinesin_assoc	KIF1B KIF1C	3.25e-04	6	88	2	PF16183
Domain	Kinesin_assoc	KIF1B KIF1C	3.25e-04	6	88	2	IPR032405
Domain	VPS13_N	VPS13C VPS13A	6.03e-04	8	88	2	IPR026854
Domain	Chorein_N	VPS13C VPS13A	6.03e-04	8	88	2	PF12624
Domain	MHC_I/II-like_Ag-recog	HLA-DRB1 HLA-DRB4 HLA-DRB5	7.57e-04	38	88	3	IPR011162
Domain	BTK	RASA4 RASA4B	7.73e-04	9	88	2	SM00107
Domain	Znf_Btk_motif	RASA4 RASA4B	7.73e-04	9	88	2	IPR001562
Domain	BTK	RASA4 RASA4B	7.73e-04	9	88	2	PF00779
Domain	ZF_BTK	RASA4 RASA4B	7.73e-04	9	88	2	PS51113
Domain	-	NPTN IGSF22 NTM HLA-DRB1 HLA-DRB4 HLA-DRB5 OBSCN FCRLB IL1R1 PTK7	1.11e-03	663	88	10	2.60.40.10
Domain	Cadherin_CS	FAT1 PCDHAC1 CDH23 CDH10	1.76e-03	109	88	4	IPR020894
Domain	Ig-like_fold	NPTN IGSF22 NTM HLA-DRB1 HLA-DRB4 HLA-DRB5 OBSCN FCRLB IL1R1 PTK7	1.77e-03	706	88	10	IPR013783
Domain	RasGAP	RASA4 RASA4B	1.93e-03	14	88	2	SM00323
Domain	RasGAP_CS	RASA4 RASA4B	1.93e-03	14	88	2	IPR023152
Domain	CADHERIN_1	FAT1 PCDHAC1 CDH23 CDH10	2.00e-03	113	88	4	PS00232
Domain	Cadherin	FAT1 PCDHAC1 CDH23 CDH10	2.00e-03	113	88	4	PF00028
Domain	CADHERIN_2	FAT1 PCDHAC1 CDH23 CDH10	2.07e-03	114	88	4	PS50268
Domain	-	FAT1 PCDHAC1 CDH23 CDH10	2.07e-03	114	88	4	2.60.40.60
Domain	C1-set	HLA-DRB1 HLA-DRB4 HLA-DRB5	2.11e-03	54	88	3	PF07654
Domain	CA	FAT1 PCDHAC1 CDH23 CDH10	2.14e-03	115	88	4	SM00112
Domain	Cadherin-like	FAT1 PCDHAC1 CDH23 CDH10	2.21e-03	116	88	4	IPR015919
Domain	RasGAP	RASA4 RASA4B	2.21e-03	15	88	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA4 RASA4B	2.21e-03	15	88	2	PS00509
Domain	RAS_GTPASE_ACTIV_2	RASA4 RASA4B	2.21e-03	15	88	2	PS50018
Domain	IGc1	HLA-DRB1 HLA-DRB4 HLA-DRB5	2.34e-03	56	88	3	SM00407
Domain	Cadherin	FAT1 PCDHAC1 CDH23 CDH10	2.35e-03	118	88	4	IPR002126
Domain	-	RASA4 RASA4B	2.52e-03	16	88	2	1.10.506.10
Domain	Ig_C1-set	HLA-DRB1 HLA-DRB4 HLA-DRB5	2.59e-03	58	88	3	IPR003597
Domain	Ig/MHC_CS	HLA-DRB1 HLA-DRB4 HLA-DRB5	2.59e-03	58	88	3	IPR003006
Domain	IG_MHC	HLA-DRB1 HLA-DRB4 HLA-DRB5	2.85e-03	60	88	3	PS00290
Domain	RasGAP_dom	RASA4 RASA4B	3.20e-03	18	88	2	IPR001936
Domain	IG	NPTN IGSF22 NTM OBSCN FCRLB IL1R1 PTK7	3.73e-03	421	88	7	SM00409
Domain	Ig_sub	NPTN IGSF22 NTM OBSCN FCRLB IL1R1 PTK7	3.73e-03	421	88	7	IPR003599
Domain	-	SMCHD1 TOP2B	3.95e-03	20	88	2	3.30.565.10
Domain	HATPase_C	SMCHD1 TOP2B	4.35e-03	21	88	2	IPR003594
Domain	PH	RASA4 KIF1B OBSCN RASA4B ARAP2	4.56e-03	229	88	5	PF00169
Pathway	BIOCARTA_BBCELL_PATHWAY	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.88e-05	11	70	3	M22030
Pathway	BIOCARTA_EOSINOPHILS_PATHWAY	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.88e-05	11	70	3	M22048
Pathway	BIOCARTA_IL5_PATHWAY	HLA-DRB1 HLA-DRB4 HLA-DRB5	3.24e-05	13	70	3	M18928
Pathway	BIOCARTA_MHC_PATHWAY	HLA-DRB1 HLA-DRB4 HLA-DRB5	4.10e-05	14	70	3	M22023
Pathway	BIOCARTA_TCRA_PATHWAY	HLA-DRB1 HLA-DRB4 HLA-DRB5	4.10e-05	14	70	3	M10765
Pathway	BIOCARTA_BLYMPHOCYTE_PATHWAY	HLA-DRB1 HLA-DRB4 HLA-DRB5	4.10e-05	14	70	3	M1473
Pathway	KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_NFY_MEDIATED_TRANSCRIPTION	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.11e-05	15	70	3	M47588
Pathway	KEGG_MEDICUS_REFERENCE_ANTIGEN_PROCESSING_AND_PRESENTATION_BY_MHC_CLASS_II_MOLECULES	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.11e-05	15	70	3	M47604
Pathway	BIOCARTA_ASBCELL_PATHWAY	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.11e-05	15	70	3	M7298
Pathway	BIOCARTA_CSK_PATHWAY	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.69e-04	22	70	3	M6327
Pathway	BIOCARTA_CTLA4_PATHWAY	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.69e-04	22	70	3	M1467
Pathway	BIOCARTA_TH1TH2_PATHWAY	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.93e-04	23	70	3	M6705
Pathway	REACTOME_PD_1_SIGNALING	HLA-DRB1 HLA-DRB4 HLA-DRB5	3.51e-04	28	70	3	M18810
Pathway	BIOCARTA_INFLAM_PATHWAY	HLA-DRB1 HLA-DRB4 HLA-DRB5	3.91e-04	29	70	3	M6910
Pathway	KEGG_VIRAL_MYOCARDITIS	HLA-DRB1 HLA-DRB4 HLA-DRB5 EIF4G3	3.99e-04	70	70	4	M12294
Pathway	KEGG_ASTHMA	HLA-DRB1 HLA-DRB4 HLA-DRB5	4.32e-04	30	70	3	M13950
Pathway	REACTOME_SENSORY_PROCESSING_OF_SOUND	MYO3A PCLO CDH23 GSN	5.74e-04	77	70	4	M41822
Pathway	KEGG_ALLOGRAFT_REJECTION	HLA-DRB1 HLA-DRB4 HLA-DRB5	8.07e-04	37	70	3	M18615
Pathway	KEGG_HEMATOPOIETIC_CELL_LINEAGE	HLA-DRB1 HLA-DRB4 HLA-DRB5 IL1R1	9.10e-04	87	70	4	M6856
Pathway	REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES	HLA-DRB1 HLA-DRB4 HLA-DRB5	9.43e-04	39	70	3	M16523
Pathway	KEGG_GRAFT_VERSUS_HOST_DISEASE	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.09e-03	41	70	3	M13519
Pubmed	Recent origin of HLA-DRB1 alleles and implications for human evolution.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.62e-08	3	89	3	9500545
Pubmed	A novel DRB1*09 allelic sequence in the Jing ethnic minority of China.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.62e-08	3	89	3	12121280
Pubmed	HLA-DR allele frequencies in Mexican mestizos with autoimmune liver diseases including overlap syndromes.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.62e-08	3	89	3	19811438
Pubmed	Polymorphism of human Ia antigens generated by reciprocal intergenic exchange between two DR beta loci.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.62e-08	3	89	3	3099214
Pubmed	A novel HLA-DRB109 allele, HLA-DRB1090103*, isolated from the Han population of Guangdong, China.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.62e-08	3	89	3	15730527
Pubmed	[Association of hemorrhagic fever with renal syndrome and HLA-DRB allele polymorphisms in Han nationality, Hubei province].	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.62e-08	3	89	3	20193583
Pubmed	Identification of a novel HLA-DRB109 allele, DRB10904, in the Korean population, by sequence-based typing.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.62e-08	3	89	3	16441501
Pubmed	Complete cDNA sequences of the HLA-DRB10402 and DRB111041 alleles.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.62e-08	3	89	3	12358860
Pubmed	Mhc-DRB diversity of the chimpanzee (Pan troglodytes).	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.62e-08	3	89	3	1428007
Pubmed	Direct sequencing of SSP-PCR-amplified cDNA to identify new alleles in the DR52-associated DRB1 group: identification of DRB11115, DRB11117 and DRB1*1319.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.62e-08	3	89	3	7652736
Pubmed	Allelic diversity is generated by intraexon sequence exchange at the DRB1 locus of primates.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.62e-08	3	89	3	2023919
Pubmed	Shared class II MHC polymorphisms between humans and chimpanzees.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.62e-08	3	89	3	2511168
Pubmed	Allelic variation in the DR subregion of the human major histocompatibility complex.	HLA-DRB1 HLA-DRB4 HLA-DRB5	6.47e-08	4	89	3	3476943
Pubmed	Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes.	HLA-DRB1 HLA-DRB4 HLA-DRB5	6.47e-08	4	89	3	26740600
Pubmed	Analysis of DR beta and DQ beta chain cDNA clones from a DR7 haplotype.	HLA-DRB1 HLA-DRB4 HLA-DRB5	6.47e-08	4	89	3	3020127
Pubmed	HLA-DRB alleles and systemic lupus erythematosus in Jamaicans.	HLA-DRB1 HLA-DRB4 HLA-DRB5	6.47e-08	4	89	3	12144077
Pubmed	Associations of human leukocyte antigen DRB with resistance or susceptibility to HIV-1 infection in the Pumwani Sex Worker Cohort.	HLA-DRB1 HLA-DRB4 HLA-DRB5	6.47e-08	4	89	3	18520346
Pubmed	HLA DR B104, 07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis.	KRT17 HLA-DRB1 HLA-DRB4	6.47e-08	4	89	3	15795121
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	CNNM3 FAT1 NUP155 KRT17 VPS13C KIF1B VPS13A TMF1 MCM7 LBR EIF4G3 SLC30A1 ARAP2	9.23e-08	777	89	13	35844135
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	CNNM3 NPTN NUP155 XPO5 TRABD NUP210 PPIL2 KPNA6 DDX20 EXT2 LBR EIF4G3 PTK7 ITPR3	1.21e-07	942	89	14	31073040
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	KRT17 SMCHD1 PCLO VPS13A SMARCA1 ATP11A LIMCH1 PLEC NEB EIF4G3 IL1R1 RNF17 PCK1 TOP2B DYNC1I1 PTK7 RPS6KC1	1.29e-07	1442	89	17	35575683
Pubmed	Antinuclear antibodies and HLA class II alleles in Jamaican patients with systemic lupus erythematosus.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.61e-07	5	89	3	17910142
Pubmed	Major histocompatibility complex class II molecules promote human immunodeficiency virus type 1 assembly and budding to late endosomal/multivesicular body compartments.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.61e-07	5	89	3	16973583
Pubmed	Genetic variability in HIV-1 gp120 affects interactions with HLA molecules and T cell receptor.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.61e-07	5	89	3	1970352
Pubmed	Cross-reactive cytotoxic T lymphocytes induced by V3 loop synthetic peptides from different strains of human immunodeficiency virus type 1.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.61e-07	5	89	3	7645219
Pubmed	A comparison of HLA-DR and -DQ allele and haplotype frequencies in Trinidadian populations of African, South Asian, and mixed ancestry.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.61e-07	5	89	3	12392858
Pubmed	HLA-DQ8 and the HLA-DQ8-DR4 haplotype are positively associated with the hevein-specific IgE immune response in health care workers with latex allergy.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.61e-07	5	89	3	12209103
Pubmed	HLA-DQA is associated with abdominal aortic aneurysms in the Belgian population.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.61e-07	5	89	3	17182961
Pubmed	NY-ESO-1 119-143 is a promiscuous major histocompatibility complex class II T-helper epitope recognized by Th1- and Th2-type tumor-reactive CD4+ T cells.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.61e-07	5	89	3	11782380
Pubmed	Expansion of monocytic myeloid-derived suppressor cells dampens T cell function in HIV-1-seropositive individuals.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.61e-07	5	89	3	23152536
Pubmed	HLA-DR-restricted peptides identified in the Nef protein can induce HIV type 1-specific IL-2/IFN-gamma-secreting CD4+ and CD4+ /CD8+ T cells in humans after lipopeptide vaccination.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.61e-07	5	89	3	17411376
Pubmed	Productive human immunodeficiency virus type 1 assembly takes place at the plasma membrane.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.61e-07	5	89	3	17507489
Pubmed	Competition of HLA-DR and a beta 2 domain peptide for HIV envelope glycoprotein gp120 binding to CD4.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.61e-07	5	89	3	7734415
Pubmed	Visual hallucinations and HLA class II antigens in cortical dementia.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.61e-07	5	89	3	20606439
Pubmed	HLA-DR and DQB1 gene polymorphism in the North-western Colombian population.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.61e-07	5	89	3	12144632
Pubmed	HIV-1 gag polyprotein rescues HLA-DR intracellular transport in a human CD4+ cell line.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.61e-07	5	89	3	12202216
Pubmed	Defining the membrane proteome of NK cells.	CNNM3 NUP155 DOCK8 PREP HLA-DRB1 HLA-DRB5 NUP210 MCM7 KPNA6 ATP11A DDX20 EXT2 LBR FMNL1 ITPR3	2.66e-07	1168	89	15	19946888
Pubmed	Association of immune responses to mycobacterium tuberculosis peptide antigens with host genetic factors.	HLA-DRB1 HLA-DRB4 HLA-DRB5	3.22e-07	6	89	3	17153701
Pubmed	MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.	HLA-DRB1 HLA-DRB4 HLA-DRB5	3.22e-07	6	89	3	18305173
Pubmed	HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma.	HLA-DRB1 HLA-DRB4 HLA-DRB5	3.22e-07	6	89	3	15902698
Pubmed	HLA risk markers for chronic myelogenous leukemia in Eastern Canada.	HLA-DRB1 HLA-DRB4 HLA-DRB5	3.22e-07	6	89	3	19235017
Pubmed	A comparison of molecular HLA-DR and DQ allele profiles forming DR51-, DR52-, and DR53-related haplotypes in five ethnic Thai populations from mainland southeast Asia.	HLA-DRB1 HLA-DRB4 HLA-DRB5	3.22e-07	6	89	3	11082517
Pubmed	Complete coding sequences and haplotypic associations of HLA-B0707, -B1524, -B4405, -B4802, -DRB10409, -DRB10411, -DRB11115, -DRB11305, and the novel allele -DRB1*0709. Group-specific amplification of cDNA from DRB1 alleles associated to DRB3 and DRB4.	HLA-DRB1 HLA-DRB4 HLA-DRB5	3.22e-07	6	89	3	15896200
Pubmed	HLA class II DNA typing in a large series of European patients with systemic lupus erythematosus: correlations with clinical and autoantibody subsets.	HLA-DRB1 HLA-DRB4 HLA-DRB5	3.22e-07	6	89	3	11997714
Pubmed	HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.	HLA-DRB1 HLA-DRB4 HLA-DRB5	3.22e-07	6	89	3	14508706
Pubmed	SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation.	SMCHD1 SMARCA1 MCM7 LBR	4.09e-07	24	89	4	18425126
Pubmed	Anti-cofactor autoantibodies in systemic lupus erythematosus: prevalence, clinical and HLA class II associations.	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.63e-07	7	89	3	18569076
Pubmed	The HIV core protein p24 inhibits interferon-gamma-induced increase of HLA-DR and cytochrome b heavy chain mRNA levels in the human monocyte-like cell line THP1.	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.63e-07	7	89	3	1905983
Pubmed	Human macrophages accumulate HIV-1 particles in MHC II compartments.	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.63e-07	7	89	3	12230470
Pubmed	[Human leukocyte antigen genes to genetic predisposition in diffuse panbronchiolitis].	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.63e-07	7	89	3	18846964
Pubmed	The impact of anti-HY responses on outcome in current and subsequent pregnancies of patients with recurrent pregnancy losses.	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.63e-07	7	89	3	20307907
Pubmed	Association of HY-restricting HLA class II alleles with pregnancy outcome in patients with recurrent miscarriage subsequent to a firstborn boy.	HLA-DRB1 HLA-DRB4 HLA-DRB5	8.99e-07	8	89	3	19223392
Pubmed	Correlation between HLA and pityriasis rosea susceptibility in Brazilian blacks.	HLA-DRB1 HLA-DRB4 HLA-DRB5	8.99e-07	8	89	3	16405603
Pubmed	HLA-A, B, Cw, DRB1, DRB3/4/5, DQB1 in German patients suffering from rapidly progressive periodontitis (RPP) and adult periodontitis (AP).	HLA-DRB1 HLA-DRB4 HLA-DRB5	8.99e-07	8	89	3	12296785
Pubmed	HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.	KIF1B DYNC1I1 KIF1C	8.99e-07	8	89	3	25818806
Pubmed	Human leukocyte antigen class I and class II allele frequencies and HIV-1 infection associations in a Chinese cohort.	HLA-DRB1 HLA-DRB4 HLA-DRB5	8.99e-07	8	89	3	17106278
Pubmed	Human plasmacytoid dendritic cells efficiently capture HIV-1 envelope glycoproteins via CD4 for antigen presentation.	HLA-DRB1 HLA-DRB4 HLA-DRB5	8.99e-07	8	89	3	23729440
Pubmed	Fusion of ubiquitin to HIV gag impairs human monocyte-derived dendritic cell maturation and reduces ability to induce gag T cell responses.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.35e-06	9	89	3	24505475
Pubmed	Major histocompatibility complex class-II molecules promote targeting of human immunodeficiency virus type 1 virions in late endosomes by enhancing internalization of nascent particles from the plasma membrane.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.35e-06	9	89	3	23170932
Pubmed	Immunoregulatory effects of HIV-1 Nef protein.	HLA-DRB1 HLA-DRB4 HLA-DRB5 MAP3K5	1.36e-06	32	89	4	19449444
Pubmed	Differential effects of R5 and X4 human immunodeficiency virus type 1 infection on CD4+ cell proliferation and activation.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.92e-06	10	89	3	15784911
Pubmed	Roles of HLA-B, HLA-C and HLA-DPA1 incompatibilities in the outcome of unrelated stem-cell transplantation.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.92e-06	10	89	3	12956878
Pubmed	HIV-gp 160-induced T cell-dependent B cell differentiation. Role of T cell-B cell activation molecule and IL-6.	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.92e-06	10	89	3	8450224
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CNNM3 NUP155 KRT17 SLC20A1 SMCHD1 NUP210 MCM7 LBR PLEC RUVBL2 TOP2B GSN ITPR3	2.06e-06	1024	89	13	24711643
Pubmed	Polymorphism and linkage of the alpha A-crystallin gene in t-haplotypes of the mouse.	HLA-DRB1 HLA-DRB5 ITPR3	2.63e-06	11	89	3	3036643
Pubmed	Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART.	HLA-DRB1 HLA-DRB4 HLA-DRB5	2.63e-06	11	89	3	21085635
Pubmed	Intracellular overexpression of HIV-1 Nef impairs differentiation and maturation of monocytic precursors towards dendritic cells.	HLA-DRB1 HLA-DRB4 HLA-DRB5	2.63e-06	11	89	3	22808111
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	NUP155 KRT17 RBM3 SMCHD1 POLR2C PPIL2 MCM7 KPNA6 DDX20 PLEC SLC30A1 RUVBL2 TOP2B GSN KIF1C	2.90e-06	1415	89	15	28515276
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	NUP155 XPO5 NUP210 MCM7 KPNA6 DDX20 LBR PLEC RUVBL2 TOP2B	5.57e-06	638	89	10	33239621
Pubmed	HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4.	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.78e-06	14	89	3	7512597
Pubmed	HIV-1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56(dim) and CD56(bright) NK cell subsets.	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.78e-06	14	89	3	17431094
Pubmed	Interaction of CD4 with HLA class II antigens and HIV gp120.	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.78e-06	14	89	3	1869305
Pubmed	Two distinct subtypes of the HLA-DRw12 haplotypes in the Japanese population detected by nucleotide sequence analysis and oligonucleotide genotyping.	HLA-DRB1 HLA-DRB4	6.48e-06	2	89	2	2592019
Pubmed	Interaction of H-2Eb with an IAP retrotransposon in the A20/2J B cell lymphoma.	HLA-DRB1 HLA-DRB5	6.48e-06	2	89	2	1353478
Pubmed	Complete cDNA sequences of the HLA-DRB114011, 1402, 1403 and 1404 alleles.	HLA-DRB1 HLA-DRB5	6.48e-06	2	89	2	11972886
Pubmed	Novel HLA-DRB1 alleles discovered during routine sequencing based typing, DRB103052, DRB104032, DRB11139 and DRB11346.	HLA-DRB1 HLA-DRB5	6.48e-06	2	89	2	12028548
Pubmed	Complete coding region sequence of E beta k cDNA clones: lack of polymorphism in the NH2-terminus between E beta k and E beta b molecules.	HLA-DRB1 HLA-DRB5	6.48e-06	2	89	2	3150763
Pubmed	Complete cDNA sequence of the HLA-DRB1*09012 allele.	HLA-DRB1 HLA-DRB5	6.48e-06	2	89	2	9777332
Pubmed	Structural comparison of the genes of two HLA-DR supertypic groups: the loci encoding DRw52 and DRw53 are not truly allelic.	HLA-DRB1 HLA-DRB4	6.48e-06	2	89	2	3596674
Pubmed	Isolation and characterization of a cDNA clone for the murine I-E beta polypeptide chain.	HLA-DRB1 HLA-DRB5	6.48e-06	2	89	2	6324181
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4 RASA4B	6.48e-06	2	89	2	11448776
Pubmed	Mouse MHC class II gene E beta 2 is closely related to E beta and to HLA-DR beta.	HLA-DRB1 HLA-DRB5	6.48e-06	2	89	2	2989167
Pubmed	Structural organization of the DR subregion of the human major histocompatibility complex.	HLA-DRB1 HLA-DRB4	6.48e-06	2	89	2	3860851
Pubmed	HLA-DR2 subtypes form an additional supertypic family of DR beta alleles.	HLA-DRB1 HLA-DRB5	6.48e-06	2	89	2	2885840
Pubmed	HLA-DR4 as a risk allele for autism acting in mothers of probands possibly during pregnancy.	HLA-DRB1 HLA-DRB4	6.48e-06	2	89	2	19487610
Pubmed	HLA-DR association in papillary thyroid carcinoma.	HLA-DRB1 HLA-DRB4	6.48e-06	2	89	2	20164547
Pubmed	Identification of two novel HLA-DRB1 alleles, DRB10903 and DRB11145.	HLA-DRB4 HLA-DRB5	6.48e-06	2	89	2	15191532
Pubmed	Identification of a novel HLA-DRB1 allele (HLA-DRB1111902).	HLA-DRB1 HLA-DRB4	6.48e-06	2	89	2	15982264
Pubmed	Identification of a new allele, HLA-DRB11366.	HLA-DRB1 HLA-DRB5	6.48e-06	2	89	2	15982265
Pubmed	H2-Eb1 expression is upregulated in the nasal mucosa of allergic rhinitis.	HLA-DRB1 HLA-DRB5	6.48e-06	2	89	2	25543041
Pubmed	Unique sequences for two HLA-DRB1 genes expressed on distinct DRw6 haplotypes.	HLA-DRB1 HLA-DRB5	6.48e-06	2	89	2	1975801
Pubmed	Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study.	HLA-DRB1 HLA-DRB4	6.48e-06	2	89	2	15140072
Pubmed	Detection of four novel alleles: DRB11130, DRB113072, DRB11315 and DRB11331.	HLA-DRB4 HLA-DRB5	6.48e-06	2	89	2	10703621
Pubmed	[A 1:2 matched case-control study on the interaction of HPV16E6 and HLA-DR9 allele to esophageal cancer in Kazakh ethnicity, Xinjiang].	HLA-DRB1 HLA-DRB5	6.48e-06	2	89	2	20193235
Pubmed	Characterization of three HLA-DR beta genes isolated from an HLA-DR 3/4 insulin-dependent diabetic patient.	HLA-DRB4 HLA-DRB5	6.48e-06	2	89	2	3015788
Pubmed	Predicted protein sequence of the murine I-E-beta S-polypeptide chain from cDNA and genomic clones.	HLA-DRB1 HLA-DRB5	6.48e-06	2	89	2	2986145
Pubmed	A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.	HLA-DRB1 HLA-DRB5	6.48e-06	2	89	2	1085338
Pubmed	T cell receptors recognizing type II collagen in HLA-DR-transgenic mice characterized by highly restricted V beta usage.	HLA-DRB1 HLA-DRB4	6.48e-06	2	89	2	15188377
Pubmed	Complete characterization and sequence of an HLA class II DR beta chain cDNA from the DR5 haplotype.	HLA-DRB1 HLA-DRB5	6.48e-06	2	89	2	3456344
Pubmed	Molecular basis for the defective expression of the mouse Ew17 beta gene.	HLA-DRB1 HLA-DRB5	6.48e-06	2	89	2	2460545
Interaction	ARL10 interactions	NUP155 KRT17 VPS13C KIF1B MCM7 LBR EIF4G3 SLC30A1	1.75e-06	189	88	8	int:ARL10
Interaction	RHOF interactions	CNNM3 FAT1 NUP155 XPO5 DOCK8 TRABD VPS13A ATP11A LBR SLC30A1 FMNL1 TOP2B	3.52e-05	673	88	12	int:RHOF
Interaction	CDC42 interactions	CNNM3 FAT1 NUP155 DOCK8 TRABD POLR2C NUP210 VPS13A MCM7 ATP11A LBR SLC30A1 FMNL1 TOP2B DYNC1I1 ARAP2 ITPR3	5.04e-05	1323	88	17	int:CDC42
Interaction	RAC1 interactions	CNNM3 FAT1 NUP155 XPO5 DOCK8 SLC20A1 TRABD VPS13A KPNA6 ATP11A LBR SLC30A1 FMNL1 DYNC1I1 ARAP2	5.23e-05	1063	88	15	int:RAC1
Interaction	NBEAL1 interactions	NPTN NUP155 KIF1C	5.23e-05	17	88	3	int:NBEAL1
Interaction	RHOA interactions	ACE2 CNNM3 FAT1 NUP155 VPS13C TRABD POLR2C NUP210 VPS13A ATP11A LBR SLC30A1 FMNL1 TOP2B ARAP2 ITPR3	5.56e-05	1199	88	16	int:RHOA
Interaction	LMBR1L interactions	CNNM3 NPTN NUP155 XPO5 TRABD NUP210 PPIL2 KPNA6 DDX20 EXT2 LBR EIF4G3 PTK7 ITPR3	5.76e-05	946	88	14	int:LMBR1L
Interaction	HRAS interactions	ACE2 CNNM3 NPTN KRT17 DHRS3 XPO5 DOCK8 RASA4 ATP11A SLC30A1 ARAP2 PTK7	7.20e-05	725	88	12	int:HRAS
Interaction	CUL7 interactions	NUP155 KRT17 DCAF8L1 SLC20A1 SMCHD1 NUP210 MCM7 LBR PLEC RUVBL2 TOP2B GSN KIF1C	7.39e-05	845	88	13	int:CUL7
Interaction	RHOJ interactions	CNNM3 FAT1 DOCK8 VPS13C VPS13A ATP11A LBR SLC30A1 FMNL1 TOP2B PTK7	9.61e-05	633	88	11	int:RHOJ
Cytoband	7q21.3-q22.1	MCM7 DYNC1I1	3.70e-05	5	89	2	7q21.3-q22.1
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	NPTN IGSF22 NTM OBSCN IL1R1 PTK7	3.15e-05	161	68	6	593
GeneFamily	C1-set domain containing	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.26e-04	42	68	3	591
GeneFamily	Histocompatibility complex\|C1-set domain containing	HLA-DRB1 HLA-DRB4 HLA-DRB5	6.03e-04	44	68	3	588
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4 RASA4B	6.15e-04	10	68	2	830
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF1B KIF28P KIF1C	6.88e-04	46	68	3	622
GeneFamily	Cadherin related	FAT1 CDH23	1.83e-03	17	68	2	24
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND6B DENND3	3.95e-03	25	68	2	504
GeneFamily	Immunoglobulin like domain containing	NPTN FCRLB IL1R1 PTK7	6.02e-03	193	68	4	594
GeneFamily	Nucleoporins	NUP155 NUP210	6.43e-03	32	68	2	1051
Coexpression	GSE36392_MAC_VS_NEUTROPHIL_IL25_TREATED_LUNG_DN	ZNF711 MYO3A DHRS3 PCDHAC1 CDH23 DHX32 IL1R1	5.10e-06	200	88	7	M5286
Coexpression	GSE6092_IFNG_VS_IFNG_AND_B_BURGDORFERI_INF_ENDOTHELIAL_CELL_UP	MCM7 KHK SOCS6 EIF4G3 FMNL1 GSN	3.28e-05	180	88	6	M6718
Coexpression	ALCALAY_AML_BY_NPM1_LOCALIZATION_DN	DHRS3 RBM3 HLA-DRB1 NUP210 ITGA9 GSN	3.94e-05	186	88	6	M19867
Coexpression	SOBOLEV_PBMC_PANDEMRIX_AGE_18_64YO_1DY_UP	HLA-DRB1 HLA-DRB4 HLA-DRB5	4.66e-05	21	88	3	M41167
Coexpression	GSE9006_1MONTH_VS_4MONTH_POST_TYPE_1_DIABETES_DX_PBMC_DN	KRT17 SLC24A2 MATN1 PCLO OBSCN IL1R1	5.27e-05	196	88	6	M5791
Coexpression	ZENG_GU_ICB_CONTROL_METAGENE_14_PRECICTIVE_ICB_RESPONSE	ACE2 RASA4 VPS13C HLA-DRB1 HLA-DRB5 RASA4B	5.58e-05	198	88	6	MM17083
Coexpression	GSE17721_PAM3CSK4_VS_GADIQUIMOD_8H_BMDC_UP	XPO5 SLC20A1 PCLO CDH23 MCM7 PLEC	5.74e-05	199	88	6	M3972
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	NUP155 DOCK8 RASA4 VPS13C SMCHD1 HMGCR LBR SLC30A1	3.41e-09	185	88	8	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	NUP155 DOCK8 RASA4 VPS13C SMCHD1 LBR SLC30A1	8.82e-08	186	88	7	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DHRS3 TRABD HLA-DRB1 HLA-DRB5 SOCS6 PLEC GSN	1.45e-07	200	88	7	80e0483d5ab0c6213aae0ec62619f57e6ec0e4c2
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	NEBL NTM ATP11A LIMCH1 DENND3 ARAP2	1.28e-06	174	88	6	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-DC-cDC2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FAT1 HLA-DRB1 HLA-DRB5 LIMCH1 PKD1L3 GSN	1.66e-06	182	88	6	1d37c486173cc4629842893ddd5033987c04086f
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-DC-cDC2-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FAT1 HLA-DRB1 HLA-DRB5 LIMCH1 PKD1L3 GSN	1.66e-06	182	88	6	aef67bdc6937b315522d39959e26c9b0acf7ab52
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-DC\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FAT1 HLA-DRB1 HLA-DRB5 LIMCH1 PKD1L3 GSN	1.66e-06	182	88	6	087c9f88daf08f5d688b728c2386f91f210d2255
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA FAT1 SLC24A2 PCLO OBSCN NEB	1.77e-06	184	88	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NEBL NTM ATP11A LIMCH1 DENND3 ARAP2	1.77e-06	184	88	6	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA FAT1 SLC24A2 PCLO OBSCN NEB	1.77e-06	184	88	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA FAT1 SLC24A2 PCLO OBSCN NEB	1.77e-06	184	88	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NEBL NTM ATP11A LIMCH1 DENND3 ARAP2	1.77e-06	184	88	6	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	PCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_B-im_B_cell_(15)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DOCK8 HLA-DRB1 HLA-DRB5 NUP210 FMNL1 ARAP2	1.83e-06	185	88	6	8fc357ee041bfd588986730a52ea2021b5f88941
ToppCell	facs-Aorta-Heart-3m-Mesenchymal\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPTN FAT1 ATP11A GALNT16 GSN PTK7	2.26e-06	192	88	6	0dc1f46e40346ed0b286e53b106a812441575100
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC24A2 VPS13C PCLO KIF1B VPS13A HMGCR	2.48e-06	195	88	6	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC24A2 VPS13C PCLO KIF1B VPS13A HMGCR	2.48e-06	195	88	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NEBL NTM ATP11A LIMCH1 DENND3 ARAP2	2.55e-06	196	88	6	6731fef8c148b6681d6ed38afdf23c8213e0bbbe
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-AT1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NEBL NTM ATP11A LIMCH1 DENND3 ARAP2	2.55e-06	196	88	6	6856317cd0cdcb88fe54b4ae905d91e13495b1c4
ToppCell	PBMC-Control-cDC_3\|Control / Compartment, Disease Groups and Clusters	DHRS3 DOCK8 HLA-DRB1 NUP210 KPNA6 PTK7	2.55e-06	196	88	6	09d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCell	(04)_Interm._basal>secr.-(2)_GFP_FOXI1\|(04)_Interm._basal>secr. / shred by cell type by condition	KRT17 VPS13C HLA-DRB1 HLA-DRB5 TMF1 LIMCH1	2.78e-06	199	88	6	53ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell	Biopsy_IPF-Epithelial-Transitional_AT2\|Biopsy_IPF / Sample group, Lineage and Cell type	NTM ATP11A DENND3 PTK7 KIF1C ITPR3	2.78e-06	199	88	6	83ff8b7e472d1212324c05cc719b746d19e5e23b
ToppCell	Biopsy_Other_PF-Epithelial-Transitional_AT2\|Biopsy_Other_PF / Sample group, Lineage and Cell type	TMEM98 NTM ATP11A LIMCH1 PTK7 ITPR3	2.86e-06	200	88	6	1ba6327851aa61e9a1f1fe1671bc27929d93ac74
ToppCell	COVID-19-COVID-19_Mild\|COVID-19 / Disease, condition lineage and cell class	RBM3 VPS13C HLA-DRB1 SMCHD1 HLA-DRB5 FMNL1	2.86e-06	200	88	6	62c25042086f1afd1102e0720e933c2e476468fd
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GREB1L NEURL1 ACOT6 SLC25A26 RNF17	1.29e-05	152	88	5	b61d2f6ee819c8dd4b4b601a8bc8388b1983de58
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Sla\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KRT17 DHRS3 OBSCN MAP3K5 PTK7	1.75e-05	162	88	5	4d13c271b4f63cf32980e5643b5d5951165fe8b5
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|390C / Donor, Lineage, Cell class and subclass (all cells)	DOCK8 RASA4 HLA-DRB1 HLA-DRB5 SDCBP2	2.15e-05	169	88	5	cfc9ff103d13a2d5eacc457e800f53fdd29f7738
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-conventional_dendritic_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NEBL HLA-DRB1 CDH23 IL1R1 RPS6KC1	2.34e-05	172	88	5	ac20766d1fd43eab8c3ff5e7418a6b38bebf0bd5
ToppCell	(07)_Ionocytes-(2)_GFP_FOXI1\|(07)_Ionocytes / shred by cell type by condition	KRT17 DHRS3 HLA-DRB1 HLA-DRB5 LIMCH1	2.34e-05	172	88	5	5776b638b845d054f6e884e7df0412477f48517d
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NEBL HLA-DRB1 CDH23 IL1R1 RPS6KC1	2.34e-05	172	88	5	3fd1bc4a8ced0bf9e26ca4ce6d83b5b97bbc2556
ToppCell	Fetal_29-31_weeks-Immune-dendritic_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK8 SLC20A1 HLA-DRB1 HLA-DRB5 FMNL1	2.68e-05	177	88	5	c5e829bc4594761666d65cace5a9c5d19c16f187
ToppCell	3'_v3-Lung-Hematopoietic_progenitors-HSC-MPP\|Lung / Manually curated celltypes from each tissue	ZNF711 TMEM98 PCLO SMARCA1 LIMCH1	2.83e-05	179	88	5	2c03b82ec9b4dee2501752b8d83e7028f0aaed77
ToppCell	PCW_13-14-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_conventional_dendritic_(19)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DOCK8 HLA-DRB1 HLA-DRB5 NUP210 FMNL1	2.83e-05	179	88	5	9fc44637c9a7551fd47b8533e45a9c199e164a95
ToppCell	facs-Marrow-B-cells-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC24A2 NTM NEURL1 FCRLB CDH10	2.90e-05	180	88	5	c54af6fb11484dacd3efa1f10a487376ff820a5e
ToppCell	facs-Marrow-B-cells-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC24A2 NTM NEURL1 FCRLB CDH10	2.90e-05	180	88	5	07ac979b21be2425294d9818c48b5a1e6f014c19
ToppCell	PCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_B-im_B_cell_(15)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DOCK8 HLA-DRB1 HLA-DRB5 FMNL1 ARAP2	2.98e-05	181	88	5	51e4d6bfdbf414d8e30aee2e6f7492f4f7f54373
ToppCell	3'_v3-blood-Myeloid_Dendritic-pDC\|blood / Manually curated celltypes from each tissue	ZNF711 NTM HLA-DRB1 HLA-DRB5 DYNC1I1	2.98e-05	181	88	5	66d890a105f955dca91d6e5e6c730d1a68ee9233
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GREB1L FAT1 NEBL DOCK8 NTM	3.06e-05	182	88	5	5e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK8 VPS13C SMCHD1 EIF4G3 TOP2B	3.06e-05	182	88	5	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	droplet-Marrow-nan-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VPS13C SMCHD1 NUP210 SOCS6 PLEC	3.06e-05	182	88	5	bc8d621be57f76d718d9b0f11e023b0f4dcb668d
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RASA4 HLA-DRB5 CDH23 RASA4B IL1R1	3.14e-05	183	88	5	a644258ba90acc62d571623e429d72ffc4b69203
ToppCell	AT1-AT2_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	NEBL NTM PCLO CDH10 DENND3	3.14e-05	183	88	5	6821dca076318115d360ff426eb1218cfe104063
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	ACE2 FAT1 NEBL DOCK8 VPS13A	3.22e-05	184	88	5	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK8 VPS13C SMCHD1 EIF4G3 TOP2B	3.22e-05	184	88	5	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D122\|Adult / Lineage, Cell type, age group and donor	NEBL NTM LIMCH1 DENND3 ARAP2	3.22e-05	184	88	5	561592edc3083fad41b91811151b442207c65dd9
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK8 VPS13C SMCHD1 EIF4G3 TOP2B	3.31e-05	185	88	5	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACE2 NEBL LIMCH1 SLC30A1 SDCBP2	3.40e-05	186	88	5	4ae3c0fe8640a8d029875cf3f0f5ffbba38e85f8
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1\|Adult / Lineage, Cell type, age group and donor	NEBL NTM LIMCH1 DENND3 ARAP2	3.48e-05	187	88	5	77f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-Activated_T\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK8 PREP NUP210 FMNL1 MAP3K5	3.66e-05	189	88	5	c38157c8cf5c0c1f560011ef5cc5892a049ee2b7
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D231\|Adult / Lineage, Cell type, age group and donor	NEBL NTM LIMCH1 DENND3 ARAP2	3.66e-05	189	88	5	5a04cb25f8f0447b2cecdb6c3695029281aca26d
ToppCell	Fetal_29-31_weeks-Immune-monocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK8 TRABD HLA-DRB1 FMNL1 DENND3	3.76e-05	190	88	5	ad297172a74a80ed5c10f921e15efd1da0fd2d6b
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NEBL GPR153 LIMCH1 GSN PTK7	3.85e-05	191	88	5	8a73d2df079566fca4cbb5cdb85721c2e87134c8
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	NUP155 VPS13C SMCHD1 HMGCR LBR	3.85e-05	191	88	5	9454f642c3621370fa23640b631301346b300950
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NEBL GPR153 LIMCH1 GSN PTK7	3.85e-05	191	88	5	ce80f65bd24b1c4d2152bf45248449e7a1a97e56
ToppCell	droplet-Lung-21m-Mesenchymal\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NEBL GPR153 LIMCH1 GSN PTK7	3.85e-05	191	88	5	10a9db1caa0fdb51ace8537f42b2c66f7c97e0f5
ToppCell	COVID-19-kidney-Myeloid\|kidney / Disease (COVID-19 only), tissue and cell type	DOCK8 SMCHD1 IL1R1 FMNL1 DENND3	3.95e-05	192	88	5	441cd1ec171f643b28e1f6f9c04def629cc7391b
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	GREB1L NEBL OBSCN LIMCH1 DYNC1I1	3.95e-05	192	88	5	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	IPF-Epithelial-Club\|Epithelial / Disease state, Lineage and Cell class	NTM ATP11A ITGA9 IL1R1 MAP3K5	3.95e-05	192	88	5	356e7a820b744a0ac87352a8d0e6e8d9fa9ed7d2
ToppCell	AT1_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	NEBL NTM LIMCH1 DENND3 ARAP2	3.95e-05	192	88	5	0444f9e9cef7403e220e862b5a787443d3f5c9ac
ToppCell	COVID-19-kidney-Myeloid\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DOCK8 SMCHD1 IL1R1 FMNL1 DENND3	3.95e-05	192	88	5	0b9d22a222f1201e375f8e55cace9ef939febae4
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HLA-DRB1 CDH23 ITGA9 IL1R1 GSN	4.05e-05	193	88	5	daefbfd3a3dd1351fbe94b9abfd807db44d56c24
ToppCell	COVID-19-lung-CD4+_T_cells_metabolically_active\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DOCK8 SMCHD1 NUP210 FMNL1 ARAP2	4.05e-05	193	88	5	326fd2ce2c4b51e5a38f2a7a09f22f8f0e92735a
ToppCell	facs-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DHRS3 NEBL VPS13C LBR TOP2B	4.05e-05	193	88	5	a6a864644e1b80b7417ea0a27281e79068a3fd3d
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	OTOA DHRS3 DOCK8 SOCS6 FMNL1	4.05e-05	193	88	5	b52d5661edff83ac4c5fe2bf89d6672016bb827b
ToppCell	10x5'-Lung-Myeloid_Dendritic-DC2\|Lung / Manually curated celltypes from each tissue	RASA4 HLA-DRB1 HLA-DRB5 IL1R1 GSN	4.05e-05	193	88	5	c97f9b13057f803df63c696c6175ef8e0aba6fa7
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT1 KRT17 NEBL TMEM98 NTM	4.15e-05	194	88	5	43eb677a76634bb9a48a40e0d607c4936ae64bcc
ToppCell	AT2_cells-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	NEBL POLR2C ATP11A HMGCR LIMCH1	4.25e-05	195	88	5	0792c1e959e933b10ae987d821ff43020dfdabad
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK8 HLA-DRB1 HLA-DRB5 CDH23 FMNL1	4.25e-05	195	88	5	62dc745e1aa3e2e58afa16c7bb2cf9b03d4e8105
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEBL NTM ATP11A LIMCH1 DENND3	4.25e-05	195	88	5	68f4cc84b5ae7f4159b780c78e4b66c94211779a
ToppCell	facs-Thymus-nan-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DHRS3 NEBL PREP LBR TOP2B	4.25e-05	195	88	5	79114b3c78cc15c413bb58f0673e7215b784a9b6
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEBL NTM ATP11A LIMCH1 DENND3	4.25e-05	195	88	5	2a1863f4b9fe73c30b0b1acf9b12fc98ef65040f
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT1 KRT17 TMEM98 NTM IL1R1	4.36e-05	196	88	5	34e79918a448f6c19b87e1b1ce13c012b24be1f8
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT1 KRT17 TMEM98 NTM IL1R1	4.36e-05	196	88	5	8f82e01ca50aa4cd6149547505b4474a02fad618
ToppCell	Leuk-UTI-Myeloid-cDC2\|Leuk-UTI / Disease, Lineage and Cell Type	RBM3 HLA-DRB1 HLA-DRB5 LIMCH1 GSN	4.36e-05	196	88	5	50465a082f03201936733c55af73bc32e1bdd024
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Club\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NEBL NTM HLA-DRB5 LIMCH1 PTK7	4.36e-05	196	88	5	d5f9168001e60bafec17fe6c702e68f5528edc20
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEBL NTM ATP11A LIMCH1 DENND3	4.36e-05	196	88	5	eb68f7954e7c2f86d05e740e95b6e74805a6053f
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK8 HLA-DRB1 HLA-DRB5 DENND3 GSN	4.36e-05	196	88	5	e54c08f88779f9fd453a4f5b85aed1f460d8a1e1
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK8 HLA-DRB1 CDH23 SOCS6 GSN	4.46e-05	197	88	5	b597c292fc1cb381a4325fed15a32966c38def28
ToppCell	Enterocyte\|World / shred on cell type and cluster	ACE2 SLC20A1 HLA-DRB1 KHK PCK1	4.46e-05	197	88	5	1dd980fd066aef21694395a4b69df938501d9631
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	ACE2 MYO3A FAT1 XPO5 TRABD	4.46e-05	197	88	5	6b6504c47c309bac4f790e2f372d454bbdea49e8
ToppCell	ASK428-Epithelial-Type_1\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	NEBL NTM LIMCH1 DENND3 ARAP2	4.46e-05	197	88	5	9ae6661c307791c3f0ecd3d378e3d917565e5498
ToppCell	Biopsy_IPF-Epithelial-AT1\|Biopsy_IPF / Sample group, Lineage and Cell type	NEBL NTM ATP11A LIMCH1 DENND3	4.57e-05	198	88	5	75bdecbe111fededf6082b11de18b84ca308ef6d
ToppCell	C_01\|World / shred on cell type and cluster	ACE2 SLC20A1 HLA-DRB1 KHK PCK1	4.57e-05	198	88	5	71d38084d09a96331877384ce6346f0de4bdcef9
ToppCell	ASK428-Epithelial-Type_1\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	NEBL NTM LIMCH1 DENND3 ARAP2	4.57e-05	198	88	5	0047a9ef7684230ac5179efea94461480e90bdaf
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Lymphocytic-Lymphocytic_NK/T-iNKT-MAIT\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DOCK8 NUP210 MCM7 FMNL1 ARAP2	4.68e-05	199	88	5	c23a53a20487a8abfeb91fa5fc9c06823dd657e9
ToppCell	Endothelial_cells-Endothelial-A\|Endothelial_cells / lung cells shred on cell class, cell subclass, sample id	SLC20A1 HLA-DRB1 HLA-DRB5 IL1R1 GSN	4.68e-05	199	88	5	2a1424c61ddcd1fea9574f7a3ad1955387458130
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK8 HLA-DRB1 CDH23 SOCS6 GSN	4.68e-05	199	88	5	b0a906586e58009f5ed9272fc29ba28e49c85ee6
ToppCell	(00)_Basal-(1)_GFP\|(00)_Basal / shred by cell type by condition	KRT17 DHRS3 PLEC SDCBP2 GSN	4.68e-05	199	88	5	105b15157f35df3fdf857e306f11e4e8200e05d4
ToppCell	COVID-19-COVID-19_Severe-Others-HSPC\|COVID-19_Severe / Disease, condition lineage and cell class	ZNF711 TMEM98 LIMCH1 ITGA9 PTK7	4.68e-05	199	88	5	25de67b6c9c8d6bb9a538e071a40ef865906c95d
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	NTM HMGCR LIMCH1 CDH10 PTK7	4.68e-05	199	88	5	a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK8 HLA-DRB1 HLA-DRB5 FMNL1 DENND3	4.68e-05	199	88	5	5ceeed92f831d068ff4bb3994f420002338330e7
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KIF1B ATP11A LBR DENND3 GSN	4.68e-05	199	88	5	b7af2b4fe6866cc8c78cf0f78390aab1b1b389ba
ToppCell	ASK428-Epithelial\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	NEBL NTM ATP11A LIMCH1 IL1R1	4.68e-05	199	88	5	ba2aaaeb4d9b448a6b9660b152fcac1a0e3fcfe7
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DHRS3 HLA-DRB1 HLA-DRB5 LIMCH1 GSN	4.68e-05	199	88	5	e6715288a586631676722f2323f0d833431161cf
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	NTM HMGCR LIMCH1 MAP3K5 PTK7	4.68e-05	199	88	5	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	21\|World / Age, Tissue, Lineage and Cell class	KRT17 DOCK8 HLA-DRB5 NUP210 FMNL1	4.68e-05	199	88	5	8c6517243168de4134e06dbe16ca89b1c2a73179
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Dividing_Basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	GREB1L MYO3A KRT17 NTM GALNT16	4.68e-05	199	88	5	f0c289523957258d16135c04679db379d43d28d9
ToppCell	proximal\|World / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KRT17 NEBL TMEM98 LIMCH1 PTK7	4.79e-05	200	88	5	33f05ed458c889bf241580f513ce66797007248c
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	SLC24A2 NTM PCLO LIMCH1 DYNC1I1	4.79e-05	200	88	5	84e4565d28a02700bf7f6730d1b3a58744ca0aea
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	SLC24A2 NTM PCLO LIMCH1 DYNC1I1	4.79e-05	200	88	5	1decf1d2cba5ebfd3e5cd4bcd637db8f193033ce
ToppCell	Sigmoid-Macrophage-Macrophage\|Sigmoid / Region, Cell class and subclass	OTOA HLA-DRB1 HLA-DRB5 ITGA9 GSN	4.79e-05	200	88	5	9ee3a799de7bade1bfe94b6827461633f02bc1dc
Drug	Quercetine dihydrate [6151-25-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A	NEBL TRABD SMCHD1 POLR2C VPS13A KPNA6 NEB EIF4G3 ARAP2	2.98e-08	180	87	9	2859_DN
Drug	Palladium	HLA-DRB1 HLA-DRB4 HLA-DRB5	1.87e-06	7	87	3	ctd:D010165
Drug	Dipivefrin hydrochloride [64019-93-8]; Up 200; 10.4uM; PC3; HT_HG-U133A	CNNM3 POLR2C VPS13A TMF1 PPIL2 SOCS6 MAP3K5	7.83e-06	188	87	7	7124_UP
Drug	Megestrol acetate [595-33-5]; Up 200; 10.4uM; HL60; HT_HG-U133A	NEBL TRABD PPIL2 IL1R1 PCK1 MAP3K5 KIF1C	9.94e-06	195	87	7	3091_UP
Drug	Progesterone [57-83-0]; Up 200; 12.8uM; HL60; HT_HG-U133A	NEBL GPR153 MATN1 PCLO NEURL1 PPIL2 GSN	9.94e-06	195	87	7	2426_UP
Drug	Norgestrel-(-)-D [797-63-7]; Up 200; 12.8uM; MCF7; HT_HG-U133A	PCLO ATP11A NEB IL1R1 PCK1 GSN KIF1C	1.06e-05	197	87	7	4730_UP
Disease	Hantavirus hemorrhagic fever with renal syndrome (is_implicated_in)	HLA-DRB1 HLA-DRB5	8.79e-06	2	88	2	DOID:11266 (is_implicated_in)
Disease	Parkinson's disease 23 (implicated_via_orthology)	VPS13C VPS13A	8.79e-06	2	88	2	DOID:0060896 (implicated_via_orthology)
Disease	choreaacanthocytosis (implicated_via_orthology)	VPS13C VPS13A	8.79e-06	2	88	2	DOID:0050766 (implicated_via_orthology)
Disease	autosomal recessive spinocerebellar ataxia 4 (implicated_via_orthology)	VPS13C VPS13A	2.63e-05	3	88	2	DOID:0111611 (implicated_via_orthology)
Disease	acute disseminated encephalomyelitis (is_implicated_in)	HLA-DRB1 HLA-DRB5	2.63e-05	3	88	2	DOID:639 (is_implicated_in)
Disease	Cohen syndrome (implicated_via_orthology)	VPS13C VPS13A	2.63e-05	3	88	2	DOID:0111590 (implicated_via_orthology)
Disease	Allergic Reaction	HLA-DRB1 HLA-DRB4 HLA-DRB5 IL1R1	3.85e-05	63	88	4	C1527304
Disease	Hypersensitivity	HLA-DRB1 HLA-DRB4 HLA-DRB5 IL1R1	4.09e-05	64	88	4	C0020517
Disease	bacterial infectious disease (is_implicated_in)	DOCK8 HLA-DRB1	5.26e-05	4	88	2	DOID:104 (is_implicated_in)
Disease	choreatic disease (is_implicated_in)	HLA-DRB1 VPS13A	8.74e-05	5	88	2	DOID:12859 (is_implicated_in)
Disease	hepatocyte nuclear factor 4-alpha measurement	HLA-DRB1 HLA-DRB5	8.74e-05	5	88	2	EFO_0801672
Disease	severe acute respiratory syndrome (is_implicated_in)	ACE2 HLA-DRB1	1.83e-04	7	88	2	DOID:2945 (is_implicated_in)
Disease	cerebellar ataxia (implicated_via_orthology)	VPS13C VPS13A	2.43e-04	8	88	2	DOID:0050753 (implicated_via_orthology)
Disease	interleukin-21 measurement	HLA-DRB1 HLA-DRB5	2.43e-04	8	88	2	EFO_0801724
Disease	FEV/FEC ratio	NPTN NEBL NTM VPS13C KIF1B NEURL1 CDH23 MCM7 NEB DENND3 TOP2B ARAP2	2.83e-04	1228	88	12	EFO_0004713
Disease	Epstein Barr virus nuclear antigen 1 IgG measurement	HLA-DRB1 HLA-DRB5	3.12e-04	9	88	2	EFO_0007790
Disease	central nervous system non-hodgkin lymphoma	HLA-DRB1 HLA-DRB5	3.12e-04	9	88	2	MONDO_0044887
Disease	HLA class II histocompatibility antigen, DQ alpha 2 chain measurement	HLA-DRB1 HLA-DRB5	3.12e-04	9	88	2	EFO_0801686
Disease	fibrinogen measurement, tissue plasminogen activator measurement	PLEC PKD1L3 IL1R1	3.32e-04	45	88	3	EFO_0004623, EFO_0004791
Disease	fibrinogen measurement, plasminogen activator inhibitor 1 measurement	PLEC PKD1L3 IL1R1	3.32e-04	45	88	3	EFO_0004623, EFO_0004792
Disease	conotruncal heart malformations	NEBL SMCHD1 NUP210 ZNF343	3.84e-04	114	88	4	MONDO_0016581
Disease	CCL19 measurement	HLA-DRB1 HLA-DRB5	3.90e-04	10	88	2	EFO_0009415
Disease	autosomal dominant nonsyndromic deafness (is_implicated_in)	GREB1L ATP11A	4.75e-04	11	88	2	DOID:0050564 (is_implicated_in)
Disease	aspirin-induced respiratory disease (is_implicated_in)	HLA-DRB1 HLA-DRB4	4.75e-04	11	88	2	DOID:0080822 (is_implicated_in)
Disease	Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive	OTOA MYO3A CDH23	4.81e-04	51	88	3	cv:CN043650
Disease	nervous system disease (implicated_via_orthology)	KIF1B KIF1C	5.69e-04	12	88	2	DOID:863 (implicated_via_orthology)
Disease	anti-Epstein Barr virus antibody measurement	HLA-DRB1 HLA-DRB5	5.69e-04	12	88	2	EFO_0009273
Disease	factor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement	PLEC PKD1L3 IL1R1	6.34e-04	56	88	3	EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Disease	fibrinogen measurement, factor VII measurement	PLEC PKD1L3 IL1R1	7.02e-04	58	88	3	EFO_0004619, EFO_0004623
Disease	PR interval	MYO3A FAT1 OBSCN PPIL2 SLC25A26 PLEC ITGA9	7.06e-04	495	88	7	EFO_0004462
Disease	platelet-to-lymphocyte ratio	TRABD HLA-DRB1 KIF1B CDH23 PLEC ITPR3	7.72e-04	363	88	6	EFO_0008446
Disease	C-C motif chemokine 19 measurement	HLA-DRB1 HLA-DRB5	7.82e-04	14	88	2	EFO_0008047
Disease	Stuttering	DHRS3 MATN1 KPNA6 DENND3	9.00e-04	143	88	4	HP_0025268
Disease	anti-anoctamin 2 antibody measurement	HLA-DRB1 HLA-DRB5	1.16e-03	17	88	2	EFO_0010150
Disease	response to interferon-beta, anti-drug antibody measurement	HLA-DRB1 HLA-DRB5	1.16e-03	17	88	2	EFO_0010559, GO_0035456
Disease	nevus count	DOCK8 SLC30A1	1.30e-03	18	88	2	EFO_0004632
Disease	late-onset myasthenia gravis	HLA-DRB1 HLA-DRB5	1.30e-03	18	88	2	EFO_1001490
Disease	cytomegalovirus virus reactivation, response to allogeneic hematopoietic stem cell transplant	PCLO CDH23	1.45e-03	19	88	2	EFO_0007044, EFO_0020106
Disease	Nonsyndromic genetic hearing loss	OTOA MYO3A CDH23	1.54e-03	76	88	3	cv:C5680182
Disease	susceptibility to strep throat measurement	MATN1 HLA-DRB1 PCLO	1.54e-03	76	88	3	EFO_0008408
Disease	Nonsyndromic Deafness	OTOA MYO3A CDH23	1.85e-03	81	88	3	C3711374
Disease	Henoch-Schoenlein purpura	HLA-DRB1 HLA-DRB5	1.95e-03	22	88	2	EFO_1000965
Disease	ubiquitin carboxyl-terminal hydrolase 25 measurement	HLA-DRB1 HLA-DRB5	1.95e-03	22	88	2	EFO_0021881
Disease	risk-taking behaviour	KRT17 SLC24A2 NTM HLA-DRB5 CDH23 KHK EIF4G3 PKD1L3	2.03e-03	764	88	8	EFO_0008579
Disease	type 1 diabetes mellitus (is_implicated_in)	HLA-DRB1 IL1R1 ITPR3	2.12e-03	85	88	3	DOID:9744 (is_implicated_in)
Disease	skin aging measurement	SLC24A2 PREP PKD1L3 ARAP2	2.14e-03	181	88	4	EFO_0008006
Disease	liver fibrosis measurement	TRABD HMGCR ITPR3	2.19e-03	86	88	3	EFO_0010576
Disease	Liver Cirrhosis, Experimental	FAT1 DHRS3 SLC20A1 RBM3 HMGCR FMNL1 PCK1 GSN	2.20e-03	774	88	8	C0023893
Disease	non-Hodgkins lymphoma	NTM HLA-DRB1	2.52e-03	25	88	2	EFO_0005952
Disease	multisite chronic pain	DDX20 DYNC1I1 ITPR3	2.91e-03	95	88	3	EFO_0010100
Disease	Nephrotic Syndrome	XPO5 HLA-DRB1	2.94e-03	27	88	2	C0027726

Protein segments in the cluster

Peptide	Gene	Start	Entry
VRLVKRDVRTPFAVE	ACOT6	91	Q3I5F7
VTTQRTFVFRVEKEE	ARAP2	546	Q8WZ64
VRNKVIEQRVPVLAS	DDX20	631	Q9UHI6
SVRFVIDVGVERRKV	DHX32	351	Q7L7V1
VVQVRIPSRVDKSES	DENND6B	211	Q8NEG7
TDIRIFPTDLVKRTV	DENND3	586	A2RUS2
EFVISPVEGVLRVRK	CDH23	1791	Q9H251
QRVKEDHTRVVSPII	GALNT16	226	Q8N428
IVKVDNEPIIRTATV	RASA4	31	O43374
PISEVVVVKDRETQR	RBM3	31	P98179
RPKEEIRIDATTVFV	PPIL2	421	Q13356
DPRDVARIESKTVIV	PCK1	81	P35558
KTVIVTQEQRDTVPI	PCK1	91	P35558
IVKVDNEPIIRTATV	RASA4B	31	C9J798
KEAFAIVSVPVSEIR	ITPR3	426	Q14573
ELAVRTFEVTPIRAK	LBR	191	Q14739
IKISEFRVVVARIGT	OTOA	981	Q7RTW8
AIAIPVTVAFVVDRR	NUP210	1776	Q8TEM1
AREEPQLFSTVVVKV	FAT1	901	Q14517
IDEVINTPRVVDRFV	KPNA6	116	O60684
VDSSRSVRPVEFEKV	MATN1	46	P21941
ESFTVQRRVEPKVTV	HLA-DRB5	116	Q30154
DVAAPVVRRVKVTVN	NTM	206	Q9P121
KVTARVVSRRNPEDV	RPS6KC1	31	Q96S38
VVCEAVIPAKVVREV	HMGCR	706	P04035
VKVAVRVRPFNSRET	KIF1B	6	O60333
SKVTQVDFLPREVVS	DYNC1I1	151	O14576
TPSIRARVDAKVEII	PCLO	3536	Q9Y6V0
QADRRAFTVPTIVVE	GPR153	206	Q6NV75
VKVAVRVRPFNARET	KIF1C	6	O43896
FSKVDFIIIVPRSEV	GREB1L	701	Q9C091
VTVRGIVTRVSEVKP	MCM7	161	P33993
ARTIDRSVFKPIVQI	NUP155	331	O75694
TSARLEVRVKPVVFL	OBSCN	2636	Q5VST9
PTDAVKQRVVVVVRD	PCDHAC1	626	Q9H158
ELEPRVFREVTVKGI	PREP	416	P48147
HVKRRVQDVISPIVF	ITGA9	561	Q13797
PVKVTERQTAVFEIR	IGSF22	336	Q8N9C0
EPVTTRQVRTIVEEV	KRT17	401	Q04695
RISVIQKEEFVLTPI	DOCK8	1931	Q8NF50
NPKETTRVAVFVRIL	CDH10	466	Q9Y6N8
ESFTVQRRVQPKVTV	HLA-DRB1	116	P01911
VSDIIPRTEVEKAIR	ACE2	691	Q9BYF1
ESFTVQRRVQPKVTV	HLA-DRB4	116	P13762
EDIITVIKTVPFTAR	FMNL1	1066	O95466
IRVSVEVEKPREELF	KHK	166	P50053
LRQDRPASKVVVTRE	DCAF8L1	316	A6NGE4
QVKGRRVVRATEVPV	GSN	191	P06396
VAVTVQELFRAPVLR	FCRLB	186	Q6BAA4
RVPSEVVKQRAQVSA	SLC25A26	106	Q70HW3
VPLQAVVEERTVSFK	SLC20A1	306	Q8WUM9
TFRVDTAVIKQRVPI	EIF4G3	1481	O43432
RVIEFITLEENKPTR	IL1R1	211	P14778
VDSVKAVRVRPFSQR	KIF28P	6	B7ZC32
LKPETVARRTVEAVQ	DHRS3	241	O75911
ERKIIEDTVVPFTVS	LIMCH1	821	Q9UPQ0
LVEATKTDVTVVRFP	MAP3K5	546	Q99683
ATTKVPEIRDVTRIE	RUVBL2	6	Q9Y230
VRTVPIAKLDRTVAE	SMCHD1	661	A6NHR9
TTDFVDEVRAIIPRV	RPP38	186	P78345
PVRVFRLITDNTVEE	SMARCA1	616	P28370
VVDRNTVEITELPVR	TOP2B	936	Q02880
ETRKQVTFLIVFPIV	SLC24A2	466	Q9UI40
FVVPRTVNVEDTIKL	PKD1L3	676	Q7Z443
ANSIRRVFIAEVPII	POLR2C	31	P19387
SGDKIVVVVRDRPFQ	SDCBP2	176	Q9H190
VVVVRDRPFQRTVTM	SDCBP2	181	Q9H190
REVDVFSPLRISEKV	CNNM3	506	Q8NE01
SIFPRVIEGKVDQIR	ATP11A	581	P98196
VSEFQEKILEPRTTR	RNF17	1156	Q9BXT8
VAVFIGQPTEVVKVR	UCP1	126	P25874
ITKPVRRTVVDESEN	TMF1	81	P82094
RIIFAEKQVIPTRES	TRIM77	66	I1YAP6
AQIVVPVTFRDVTVI	ZNF343	56	Q6P1L6
QRIILFTEDPRVFKV	VPS13A	2496	Q96RL7
PVRVAETIFVKVTRS	NEURL1	331	O76050
VVKTIREVQPDVVVV	TRABD	91	Q9H4I3
VESLFRVITEVSKVP	EXT2	466	Q93063
QKPRIVTSEEVIIRD	NPTN	146	Q9Y639
VEESKAPRTRAVRNV	XPO5	586	Q9HAV4
ETVRVRKVDVSSVPD	VPS13C	1901	Q709C8
VQFLRRPKTITRVFE	SYNGR4	16	O95473
SSVRKRRVVIVDPET	PLEC	4271	Q15149
RRTKAENIPAVVIEI	SLC30A1	481	Q9Y6M5
TVRVPEQVFVADLVT	ZNF711	121	Q9Y462
LTVAVFITFKVEPER	PTK7	586	Q13308
IVFKDVRAQRPIRST	SOCS6	111	O14544
SDIIVVAKRISPRVD	TMEM98	126	Q9Y2Y6
TIIRPNTVEKATDVR	MYO3A	661	Q8NEV4
VDDPVTERVRKNTQV	NEBL	801	O76041
TTVTPEIERVKRNQE	NEB	6226	P20929