Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	gamma-aminobutyric acid transmembrane transporter activity	SLC32A1 SLC6A11	2.10e-04	9	49	2	GO:0015185
GeneOntologyMolecularFunction	peptide hormone binding	CMKLR2 LEPR HCRTR1	3.33e-04	55	49	3	GO:0017046
GeneOntologyMolecularFunction	secondary active monocarboxylate transmembrane transporter activity	SLC32A1 SLC6A11	9.82e-04	19	49	2	GO:0015355
GeneOntologyMolecularFunction	protein-hormone receptor activity	CMKLR2 LEPR	1.32e-03	22	49	2	GO:0016500
GeneOntologyMolecularFunction	monocarboxylic acid transmembrane transporter activity	SLC32A1 SLC6A11 SLC22A10	1.40e-03	90	49	3	GO:0008028
GeneOntologyMolecularFunction	hexosyltransferase activity	TMTC3 UGT2B15 UGT2B17 ALG3	1.77e-03	211	49	4	GO:0016758
GeneOntologyMolecularFunction	hormone binding	CMKLR2 LEPR HCRTR1	2.07e-03	103	49	3	GO:0042562
GeneOntologyMolecularFunction	retinoic acid binding	UGT2B15 UGT2B17	2.14e-03	28	49	2	GO:0001972
GeneOntologyMolecularFunction	mannosyltransferase activity	TMTC3 ALG3	2.14e-03	28	49	2	GO:0000030
GeneOntologyMolecularFunction	amino acid:monoatomic cation symporter activity	SLC32A1 SLC6A11	2.30e-03	29	49	2	GO:0005416
GeneOntologyMolecularFunction	glucuronosyltransferase activity	UGT2B15 UGT2B17	3.33e-03	35	49	2	GO:0015020
GeneOntologyMolecularFunction	transporter activity	SLC32A1 MPV17 SLC6A11 CLPTM1L ABCA2 KCNH8 PIEZO1 SLC22A10 SCN9A	3.73e-03	1289	49	9	GO:0005215
GeneOntologyMolecularFunction	glycosyltransferase activity	TMTC3 UGT2B15 UGT2B17 ALG3	5.39e-03	288	49	4	GO:0016757
GeneOntologyCellularComponent	endoplasmic reticulum membrane	CLPTM1L VMA21 JAGN1 MARCHF8 PIEZO1 ARL6IP5 UGT2B15 UGT2B17 ALG3 MARCHF1	5.97e-04	1293	48	10	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	CLPTM1L VMA21 JAGN1 MARCHF8 PIEZO1 ARL6IP5 UGT2B15 UGT2B17 ALG3 MARCHF1	6.19e-04	1299	48	10	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	CLPTM1L VMA21 JAGN1 MARCHF8 PIEZO1 ARL6IP5 UGT2B15 UGT2B17 ALG3 MARCHF1	7.31e-04	1327	48	10	GO:0042175
Domain	Tox-GHH_dom	TENM1 TENM2	4.20e-05	4	50	2	IPR028916
Domain	TENEURIN_N	TENM1 TENM2	4.20e-05	4	50	2	PS51361
Domain	Ten_N	TENM1 TENM2	4.20e-05	4	50	2	IPR009471
Domain	Tox-GHH	TENM1 TENM2	4.20e-05	4	50	2	PF15636
Domain	Ten_N	TENM1 TENM2	4.20e-05	4	50	2	PF06484
Domain	YD	TENM1 TENM2	6.99e-05	5	50	2	IPR006530
Domain	MARCH-like	MARCHF8 MARCHF1	1.95e-04	8	50	2	IPR033275
Domain	RINGv	MARCHF8 MARCHF1	3.80e-04	11	50	2	PF12906
Domain	ZF_RING_CH	MARCHF8 MARCHF1	3.80e-04	11	50	2	PS51292
Domain	NHL	TENM1 TENM2	5.38e-04	13	50	2	PS51125
Domain	Znf_RING-CH	MARCHF8 MARCHF1	9.31e-04	17	50	2	IPR011016
Domain	RINGv	MARCHF8 MARCHF1	9.31e-04	17	50	2	SM00744
Domain	UDPGT	UGT2B15 UGT2B17	1.43e-03	21	50	2	PS00375
Domain	UDPGT	UGT2B15 UGT2B17	1.43e-03	21	50	2	PF00201
Domain	UDP_glucos_trans	UGT2B15 UGT2B17	1.43e-03	21	50	2	IPR002213
Domain	Quino_amine_DH_bsu	VPS8 TENM2	1.57e-03	22	50	2	IPR011044
Domain	-	TENM1 TENM2	4.89e-03	39	50	2	2.120.10.30
Domain	6-blade_b-propeller_TolB-like	TENM1 TENM2	6.74e-03	46	50	2	IPR011042
Domain	Znf_RING	MARCHF8 VPS8 NFXL1 MARCHF1	1.12e-02	326	50	4	IPR001841
Pathway	REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE	SLC32A1 SLC6A11 ARL6IP5	1.69e-04	51	30	3	M4281
Pathway	REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE	SLC32A1 SLC6A11 ARL6IP5	1.69e-04	51	30	3	MM14499
Pubmed	Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells.	UGT2B15 UGT2B17	2.11e-06	2	51	2	32660355
Pubmed	The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence.	UGT2B15 UGT2B17	2.11e-06	2	51	2	1909870
Pubmed	Androgen glucuronidation: an unexpected target for androgen deprivation therapy, with prognosis and diagnostic implications.	UGT2B15 UGT2B17	2.11e-06	2	51	2	24121496
Pubmed	Mouse UDP glucuronosyltransferase. cDNA and complete amino acid sequence and regulation.	UGT2B15 UGT2B17	2.11e-06	2	51	2	3117546
Pubmed	Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study.	UGT2B15 UGT2B17	2.11e-06	2	51	2	24267955
Pubmed	Differential expression of the androgen-conjugating UGT2B15 and UGT2B17 enzymes in prostate tumor cells during cancer progression.	UGT2B15 UGT2B17	2.11e-06	2	51	2	22170718
Pubmed	Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5.	UGT2B15 UGT2B17	2.11e-06	2	51	2	3105095
Pubmed	UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells.	UGT2B15 UGT2B17	2.11e-06	2	51	2	17848572
Pubmed	Orexin A/Hypocretin Modulates Leptin Receptor-Mediated Signaling by Allosteric Modulations Mediated by the Ghrelin GHS-R1A Receptor in Hypothalamic Neurons.	LEPR HCRTR1	2.11e-06	2	51	2	28717967
Pubmed	MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation.	MARCHF8 MARCHF1	2.11e-06	2	51	2	21757542
Pubmed	Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17.	UGT2B15 UGT2B17	2.11e-06	2	51	2	27496708
Pubmed	Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation.	UGT2B15 UGT2B17	2.11e-06	2	51	2	28228532
Pubmed	Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium.	UGT2B15 UGT2B17	2.11e-06	2	51	2	15666817
Pubmed	The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men.	UGT2B15 UGT2B17	2.11e-06	2	51	2	17698910
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	CLPTM1L VMA21 NDC1 TMTC3 ARL6IP5 NFXL1 MARCHF1	5.30e-06	468	51	7	31056421
Pubmed	Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection.	MARCHF8 MARCHF1	6.32e-06	3	51	2	27503069
Pubmed	Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism.	UGT2B15 UGT2B17	6.32e-06	3	51	2	19572376
Pubmed	Euglycemia Restoration by Central Leptin in Type 1 Diabetes Requires STAT3 Signaling but Not Fast-Acting Neurotransmitter Release.	SLC32A1 LEPR	6.32e-06	3	51	2	26822087
Pubmed	Leptin signaling in GABA neurons, but not glutamate neurons, is required for reproductive function.	SLC32A1 LEPR	6.32e-06	3	51	2	24198376
Pubmed	Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines.	UGT2B15 UGT2B17	6.32e-06	3	51	2	26163549
Pubmed	Membrane-associated RING-CH (MARCH) 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor.	MARCHF8 MARCHF1	6.32e-06	3	51	2	23606747
Pubmed	Forkhead box protein A1 regulates UDP-glucuronosyltransferase 2B15 gene transcription in LNCaP prostate cancer cells.	UGT2B15 UGT2B17	6.32e-06	3	51	2	20736324
Pubmed	Epigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer.	UGT2B15 UGT2B17	6.32e-06	3	51	2	26385605
Pubmed	Genetic variations in UGT2B28, UGT2B17, UGT2B15 genes and the risk of prostate cancer: A case-control study.	UGT2B15 UGT2B17	6.32e-06	3	51	2	28882566
Pubmed	Glutamatergic Preoptic Area Neurons That Express Leptin Receptors Drive Temperature-Dependent Body Weight Homeostasis.	SLC32A1 LEPR	6.32e-06	3	51	2	27147656
Pubmed	Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein cleavage via targeting furin P domain.	MARCHF8 MARCHF1	6.32e-06	3	51	2	38299743
Pubmed	Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice.	SLC32A1 LEPR	6.32e-06	3	51	2	36932069
Pubmed	Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells.	UGT2B15 UGT2B17	6.32e-06	3	51	2	17988216
Pubmed	Ubiquitination by the membrane-associated RING-CH-8 (MARCH-8) ligase controls steady-state cell surface expression of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) receptor 1.	MARCHF8 MARCHF1	6.32e-06	3	51	2	23300075
Pubmed	Lateral hypothalamic LEPR neurons drive appetitive but not consummatory behaviors.	SLC32A1 LEPR	6.32e-06	3	51	2	34433027
Pubmed	Tissue distribution and relative gene expression of UDP-glucuronosyltransferases (2B7, 2B15, 2B17) in the human fetus.	UGT2B15 UGT2B17	6.32e-06	3	51	2	23223495
Pubmed	Role of GABA release from leptin receptor-expressing neurons in body weight regulation.	SLC32A1 LEPR	6.32e-06	3	51	2	22334723
Pubmed	Androgen receptor mediates the expression of UDP-glucuronosyltransferase 2 B15 and B17 genes.	UGT2B15 UGT2B17	6.32e-06	3	51	2	18302198
Pubmed	The nuclear receptor Shp regulates morphine withdrawal syndrome via modulation of Ugt2b expression in mice.	UGT2B15 UGT2B17	6.32e-06	3	51	2	30689982
Pubmed	Characteristic development of the GABA-removal system in the mouse spinal cord.	SLC32A1 SLC6A11	1.26e-05	4	51	2	24412234
Pubmed	Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83.	MARCHF8 MARCHF1	1.26e-05	4	51	2	27503071
Pubmed	Dynamic GABAergic afferent modulation of AgRP neurons.	SLC32A1 LEPR	1.26e-05	4	51	2	27643429
Pubmed	Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.	TENM1 TENM2	1.26e-05	4	51	2	10225957
Pubmed	The HLA-DRalpha chain is modified by polyubiquitination.	MARCHF8 MARCHF1	1.26e-05	4	51	2	19117940
Pubmed	An excitatory lateral hypothalamic circuit orchestrating pain behaviors in mice.	SLC32A1 LEPR	1.26e-05	4	51	2	34042586
Pubmed	Leptin Receptor Expression in GABAergic Cells is Not Sufficient to Normalize Metabolism and Reproduction in Mice.	SLC32A1 LEPR	1.26e-05	4	51	2	34402859
Pubmed	Genetic identification of leptin neural circuits in energy and glucose homeostases.	SLC32A1 LEPR	1.26e-05	4	51	2	29670283
Pubmed	Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice.	LEPR HCRTR1	1.26e-05	4	51	2	25249578
Pubmed	Calcitrol (1alpha,25-dihydroxyvitamin D3) inhibits androgen glucuronidation in prostate cancer cells.	UGT2B15 UGT2B17	1.26e-05	4	51	2	18281521
Pubmed	Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone.	SLC32A1 LEPR	1.26e-05	4	51	2	24760864
Pubmed	Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients.	UGT2B15 UGT2B17	1.26e-05	4	51	2	26176234
Pubmed	All four members of the Ten-m/Odz family of transmembrane proteins form dimers.	TENM1 TENM2	1.26e-05	4	51	2	12000766
Pubmed	A hypothalamic circuit that controls body temperature.	SLC32A1 LEPR	1.26e-05	4	51	2	28053227
Pubmed	VMAT2-Mediated Neurotransmission from Midbrain Leptin Receptor Neurons in Feeding Regulation.	SLC32A1 LEPR	2.10e-05	5	51	2	28560316
Pubmed	A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis.	PIEZO1 LEPR	2.10e-05	5	51	2	33627868
Pubmed	Hypothalamic agouti-related peptide neurons and the central melanocortin system are crucial mediators of leptin's antidiabetic actions.	SLC32A1 LEPR	2.10e-05	5	51	2	24813890
Pubmed	Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons.	SLC32A1 LEPR	3.15e-05	6	51	2	30858605
Pubmed	Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin.	SLC32A1 LEPR	3.15e-05	6	51	2	24011077
Pubmed	Steroidogenic enzymes and stem cell markers are upregulated during androgen deprivation in prostate cancer.	UGT2B15 UGT2B17	3.15e-05	6	51	2	21365123
Pubmed	Sleep modulates haematopoiesis and protects against atherosclerosis.	LEPR HCRTR1	3.15e-05	6	51	2	30760925
Pubmed	Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons.	SLC32A1 LEPR	3.15e-05	6	51	2	21745644
Pubmed	Sustained remission of type 2 diabetes in rodents by centrally administered fibroblast growth factor 4.	SLC32A1 LEPR	3.15e-05	6	51	2	37167965
Pubmed	Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.	UGT2B15 UGT2B17	4.41e-05	7	51	2	26074487
Pubmed	The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain.	TENM1 TENM2	4.41e-05	7	51	2	12915301
Pubmed	Specific subpopulations of hypothalamic leptin receptor-expressing neurons mediate the effects of early developmental leptin receptor deletion on energy balance.	SLC32A1 LEPR	4.41e-05	7	51	2	29914853
Pubmed	Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.	UGT2B15 UGT2B17	5.87e-05	8	51	2	32093886
Pubmed	Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice.	LEPR HCRTR1	5.87e-05	8	51	2	27631554
Pubmed	Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry.	UGT2B15 UGT2B17	5.87e-05	8	51	2	22579593
Pubmed	Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25.	TENM1 TENM2	5.87e-05	8	51	2	10331952
Pubmed	The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.	UGT2B15 UGT2B17	5.87e-05	8	51	2	18719240
Pubmed	Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States.	UGT2B15 UGT2B17	5.87e-05	8	51	2	20142249
Pubmed	Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states.	SLC32A1 LEPR	7.54e-05	9	51	2	30038273
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	VMA21 NDC1 ARL6IP5 VPS8 TENM1 SPG11	9.32e-05	504	51	6	34432599
Pubmed	NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and genetic forms of obesity.	SLC32A1 LEPR	9.42e-05	10	51	2	34462445
Pubmed	Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.	TENM1 TENM2	9.42e-05	10	51	2	38713721
Pubmed	Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.	UGT2B15 UGT2B17	1.38e-04	12	51	2	20308471
Pubmed	Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins.	MARCHF8 MARCHF1	2.50e-04	16	51	2	14722266
Pubmed	Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86.	MARCHF8 MARCHF1	3.18e-04	18	51	2	35411049
Pubmed	GABA neurotransmitter signaling in the developing mouse lens: dynamic regulation of components and functionality.	SLC32A1 SLC6A11	3.18e-04	18	51	2	18985723
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	CLPTM1L ABCA2 VMA21 NDC1 TMTC3 JAGN1 PIEZO1 ALG3	3.36e-04	1201	51	8	35696571
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	CLPTM1L VMA21 NDC1 TMTC3 JAGN1 ARL6IP5 NFXL1 LRCH1	3.40e-04	1203	51	8	29180619
Pubmed	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.	MPV17 CMKLR2 NAGK NFXL1 UGT2B15	4.71e-04	442	51	5	15815621
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	MPV17 CLPTM1L NDC1 TMTC3 NFXL1 ALG3	4.88e-04	686	51	6	28380382
Pubmed	Gata2, Nkx2-2 and Skor2 form a transcription factor network regulating development of a midbrain GABAergic neuron subtype with characteristics of REM-sleep regulatory neurons.	SLC32A1 HCRTR1	5.23e-04	23	51	2	35815619
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	TMTC3 ARL6IP5 NFXL1 SMG9 SPG11 MAPRE2	6.90e-04	733	51	6	34672954
Pubmed	Molecular Characterization of the Genital Organizer: Gene Expression Profile of the Mouse Urethral Plate Epithelium.	CMKLR2 BNIPL	7.23e-04	27	51	2	27173853
Pubmed	Identification of cathepsin K as a novel marker of adiposity in white adipose tissue.	CLPTM1L LEPR	8.35e-04	29	51	2	12652657
Pubmed	Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis.	PTPRN ARL6IP5	9.54e-04	31	51	2	23142642
Pubmed	ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.	VMA21 NDC1 ARL6IP5 NFXL1	9.74e-04	299	51	4	37931956
Pubmed	DNA cloning using in vitro site-specific recombination.	TRAPPC11 VMA21 TMTC3 MAMDC2 ASB4 MAPRE2	1.04e-03	794	51	6	11076863
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ABCA2 PSME4 PIEZO1 SPG11 LRCH1	1.05e-03	529	51	5	14621295
Pubmed	Diverse Central Projection Patterns of Retinal Ganglion Cells.	SLC32A1 LEPR	1.22e-03	35	51	2	28228269
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CLPTM1L NDC1 TMTC3 SF3A1 PIEZO1 ARL6IP5 NFXL1 SPG11	1.36e-03	1487	51	8	33957083
Interaction	TCTN3 interactions	CLPTM1L VMA21 NDC1 TMTC3 JAGN1 ARL6IP5 ALG3	1.52e-05	334	49	7	int:TCTN3
Interaction	CRELD1 interactions	NDC1 TMTC3 PIEZO1 SCN9A ALG3	4.66e-05	163	49	5	int:CRELD1
Interaction	OTULINL interactions	CLPTM1L VMA21 NDC1 JAGN1 ARL6IP5 NFXL1 MARCHF1	5.21e-05	405	49	7	int:OTULINL
Cytoband	4q13	UGT2B15 UGT2B17	1.26e-04	15	51	2	4q13
GeneFamily	Ring finger proteins\|Membrane associated ring-CH-type fingers	MARCHF8 MARCHF1	1.35e-04	11	29	2	60
GeneFamily	UDP glucuronosyltransferases	UGT2B15 UGT2B17	1.20e-03	32	29	2	363
GeneFamily	G protein-coupled receptors, Class A orphans	CMKLR2 GPR176	6.92e-03	78	29	2	262
Disease	cholic acid glucuronide measurement	UGT2B15 UGT2B17	8.78e-06	3	51	2	EFO_0800574
Disease	X-25937 measurement	UGT2B15 UGT2B17	1.75e-05	4	51	2	EFO_0800937
Disease	X-24574 measurement	UGT2B15 UGT2B17	6.12e-05	7	51	2	EFO_0800897
Disease	deoxycholic acid glucuronide measurement	UGT2B15 UGT2B17	8.15e-05	8	51	2	EFO_0800575
Disease	4-androsten-3alpha,17alpha-diol monosulfate (3) measurement	UGT2B15 UGT2B17	1.31e-04	10	51	2	EFO_0022090
Disease	DNA repair protein RAD51 homolog 4 measurement	UGT2B15 UGT2B17	1.59e-04	11	51	2	EFO_0801531
Disease	5alpha-androstan-3beta,17beta-diol monosulfate (2) measurement	UGT2B15 UGT2B17	1.91e-04	12	51	2	EFO_0800291
Disease	free cholesterol measurement, high density lipoprotein cholesterol measurement	TDRD15 MARCHF8 UGT2B15 UGT2B17 LEPR	2.11e-04	315	51	5	EFO_0004612, EFO_0008591
Disease	androstenediol (3alpha, 17alpha) monosulfate (3) measurement	UGT2B15 UGT2B17	2.26e-04	13	51	2	EFO_0800293
Disease	X-19141 measurement	UGT2B15 UGT2B17	2.26e-04	13	51	2	EFO_0800799
Disease	phospholipid measurement, high density lipoprotein cholesterol measurement	TDRD15 MARCHF8 UGT2B15 UGT2B17 LEPR	2.30e-04	321	51	5	EFO_0004612, EFO_0004639
Disease	lipid measurement, high density lipoprotein cholesterol measurement	TDRD15 MARCHF8 UGT2B15 UGT2B17 LEPR	2.62e-04	330	51	5	EFO_0004529, EFO_0004612
Disease	5alpha-androstan-3alpha,17alpha-diol monosulfate measurement	UGT2B15 UGT2B17	2.63e-04	14	51	2	EFO_0800283
Disease	lipoprotein measurement, phospholipid measurement	TDRD15 MARCHF8 LEPR	4.35e-04	85	51	3	EFO_0004639, EFO_0004732
Disease	5alpha-androstan-3alpha,17beta-diol monosulfate (1) measurement	UGT2B15 UGT2B17	4.40e-04	18	51	2	EFO_0800288
Disease	etiocholanolone glucuronide measurement	UGT2B15 UGT2B17	4.92e-04	19	51	2	EFO_0800362
Disease	androsterone glucuronide measurement	UGT2B15 UGT2B17	5.46e-04	20	51	2	EFO_0800317
Disease	S-warfarin to R-warfarin ratio measurement	DLEC1 GPR176 HCRTR1	6.02e-04	95	51	3	EFO_0803331
Disease	X-24947 measurement	UGT2B15 UGT2B17	6.62e-04	22	51	2	EFO_0800910
Disease	carnosine measurement	TENM2 HCRTR1	7.89e-04	24	51	2	EFO_0010470
Disease	lipoprotein measurement	TDRD15 MARCHF8 LEPR	8.05e-04	105	51	3	EFO_0004732
Disease	epiandrosterone sulfate measurement	UGT2B15 UGT2B17	8.57e-04	25	51	2	EFO_0021120
Disease	hearing threshold measurement	SLC32A1 MARCHF1	1.08e-03	28	51	2	EFO_0007618
Disease	omega-3 polyunsaturated fatty acid measurement	TDRD15 UGT2B15 UGT2B17	1.13e-03	118	51	3	EFO_0010119
Disease	osteoporosis (is_implicated_in)	UGT2B17 LEPR	1.32e-03	31	51	2	DOID:11476 (is_implicated_in)
Disease	non-high density lipoprotein cholesterol measurement	TDRD15 NDC1 MARCHF8 UGT2B15 UGT2B17 MAPRE2	1.39e-03	713	51	6	EFO_0005689
Disease	docosahexaenoic acid measurement	TDRD15 UGT2B15 UGT2B17	1.39e-03	127	51	3	EFO_0007761
Disease	cysteine-rich with EGF-like domain protein 1 measurement	SLC6A11 JAGN1	1.41e-03	32	51	2	EFO_0021870
Disease	lung carcinoma	CLPTM1L FRY ARAP3 DLEC1 MAPRE2	1.44e-03	482	51	5	EFO_0001071
Disease	choline measurement	TDRD15 MARCHF8 LEPR	1.49e-03	130	51	3	EFO_0010116
Disease	androsterone sulfate measurement	UGT2B15 UGT2B17	1.49e-03	33	51	2	EFO_0021117

Protein segments in the cluster

Peptide	Gene	Start	Entry
VWLATVHLEQYADTF	ARAP3	11	Q8WWN8
HAWFLELVVVVNHDF	ADAM21	206	Q9UKJ8
KAIEVVVNAYEHIRW	ASB4	336	Q9Y574
ITFWVIHRVAYTEID	ALG3	56	Q92685
FYAIVWVNGVDTVEH	GUSBP11	131	Q6P575
VVDWLVQVHEYLGLA	CCNP	111	Q9H8S5
AYWIAHQAVKIVFDS	NAGK	156	Q9UJ70
WIHEIEKYGAANVVI	RAB19	111	A4D1S5
YIFEENHVVQEKIWS	MAMDC2	431	Q7Z304
LYHVYEVNLVSEHIW	PTPRN	831	Q16849
IYHTDINILVDTVWA	KPNA3	251	O00505
GVVVVVFAWYITHDV	NFXL1	896	Q6ZNB6
ELVMYIWAHAVVASV	GPR176	161	Q14439
VLVLAVQVHAWQLYY	JAGN1	151	Q8N5M9
HRVQEYFEWAAQVVK	HDDC3	141	Q8N4P3
ALVVVHATWYVKAFL	BNIPL	291	Q7Z465
LVEFEVVYHTAWIRE	DNAH8	561	Q96JB1
ILFIVLVYITYHWNA	LRCH1	711	Q9Y2L9
FHVIAITCVVWSLYV	MARCHF8	161	Q5T0T0
FCVVLLHWEFIYVIT	LEPR	6	P48357
FHVIAITCVVWSLYV	MARCHF1	161	Q8TCQ1
EWVLIAAYVAVFVVA	HCRTR1	46	O43613
HVVIIWLFLAVYAVA	ABCA2	781	Q9BZC7
HDIIAWVNDIVSLNY	MAPRE2	61	Q15555
LVEWNAVLVNSHYDV	FRY	821	Q5TBA9
IRNATHVELAFYWQI	DLEC1	636	Q9Y238
QALLGQVVYAHIDWF	TDRD15	376	B5MCY1
LAYVFRDWQTLHVVA	SLC22A10	251	Q63ZE4
IVVVLVFTGFVWAAH	ARL6IP5	71	O75915
QHMTEVLYWINVVFI	SCN9A	1541	Q15858
LFTVCHVVIVVQDWF	SMG9	311	Q9H0W8
YVIAVHLFGLTWQLQ	TENM1	336	Q9UKZ4
NEAVFVQYLDVGLWH	TENM2	536	Q9NT68
LHYRLAVVQCVAVIW	MPV17	151	P39210
VPLLAWHFVAVQNYV	VPS8	351	Q8N3P4
YAQIDWHDFVVVETV	SF3A1	271	Q15459
QEIEHVFLVNLWYSF	STK32C	146	Q86UX6
LVVGVFVVYVVHTCW	CLPTM1L	11	Q96KA5
VVHWVSLVLYCLAFV	CMKLR2	36	P46091
IILWIGEFQTQHSYA	SPG11	896	Q96JI7
DVVYNAVHRAVWDAF	TRAPPC11	26	Q7Z392
AHLNVYYIIILAWAI	SLC6A11	141	P48066
FLTNAYDIGHAVIWI	PSME4	301	Q14997
VHVVLALFVYVAWNE	VMA21	76	Q3ZAQ7
LWHQVFFDVAIFVIG	SLC32A1	486	Q9H598
ELHVFKLVALYTVWV	PIEZO1	811	Q92508
WIQYHSLDVIAFLLA	UGT2B15	486	P54855
NADLWYNLAIVHIEL	TMTC3	596	Q6ZXV5
WIQYHSLDVIAFLLA	UGT2B17	486	O75795
CVVYVFSNFVWLVIH	PRO1933	56	Q9H354
IHYVTTWFIIDLIAA	KCNH8	296	Q96L42
VSWILFKIYATEAHV	NDC1	286	Q9BTX1