Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein geranylgeranyltransferase activity	CHM PGGT1B	5.40e-05	5	47	2	GO:0004661
GeneOntologyMolecularFunction	retinoic acid-responsive element binding	RXRA RXRB	1.13e-04	7	47	2	GO:0044323
GeneOntologyMolecularFunction	protein prenyltransferase activity	CHM PGGT1B	1.50e-04	8	47	2	GO:0008318
GeneOntologyMolecularFunction	cytoskeletal protein binding	VAPA LGMN ROCK1 CCDC88A MYH13 SPATA31A6 USH2A HAP1 SYNE2 EML6	1.96e-04	1099	47	10	GO:0008092
GeneOntologyMolecularFunction	GDP-dissociation inhibitor activity	CCDC88A CHM	7.21e-04	17	47	2	GO:0005092
GeneOntologyMolecularFunction	prenyltransferase activity	CHM PGGT1B	8.10e-04	18	47	2	GO:0004659
GeneOntologyMolecularFunction	nuclear vitamin D receptor binding	RXRA RXRB	8.10e-04	18	47	2	GO:0042809
GeneOntologyBiologicalProcess	positive regulation of epidermal growth factor receptor signaling pathway	CCDC88A FASLG HAP1	4.77e-05	31	47	3	GO:0045742
GeneOntologyBiologicalProcess	positive regulation of ERBB signaling pathway	CCDC88A FASLG HAP1	5.77e-05	33	47	3	GO:1901186
GeneOntologyBiologicalProcess	regulation of ERBB signaling pathway	LGMN CCDC88A FASLG HAP1	5.96e-05	93	47	4	GO:1901184
GeneOntologyBiologicalProcess	positive regulation of molecular function	LGMN ROCK1 CARD11 CCDC88A KCNIP2 UACA FASLG ARHGEF26 HAP1 MTCH1 RXRA PREX2	6.31e-05	1430	47	12	GO:0044093
GeneOntologyBiologicalProcess	positive regulation of vitamin D receptor signaling pathway	RXRA RXRB	7.58e-05	6	47	2	GO:0070564
GeneOntologyBiologicalProcess	canonical NF-kappaB signal transduction	VAPA ROCK1 CARD11 UACA FASLG EDNRB	9.90e-05	330	47	6	GO:0007249
GeneOntologyBiologicalProcess	positive regulation of hydrolase activity	LGMN ROCK1 UACA FASLG ARHGEF26 MTCH1 PREX2	1.27e-04	499	47	7	GO:0051345
GeneOntologyBiologicalProcess	protein geranylgeranylation	CHM PGGT1B	1.41e-04	8	47	2	GO:0018344
GeneOntologyBiologicalProcess	regulation of vitamin D receptor signaling pathway	RXRA RXRB	2.26e-04	10	47	2	GO:0070562
Domain	Retinoid-X_rcpt/HNF4	RXRA RXRB	2.52e-04	10	45	2	IPR000003
Domain	Recoverin	KCNIP4 KCNIP2	4.35e-04	13	45	2	IPR028846
Domain	EF-hand_7	KCNIP4 PEF1 KCNIP2	1.12e-03	85	45	3	PF13499
Domain	EF-hand_8	KCNIP4 KCNIP2	3.03e-03	34	45	2	PF13833
Domain	zf-C4	RXRA RXRB	5.49e-03	46	45	2	PF00105
Domain	NUCLEAR_REC_DBD_1	RXRA RXRB	5.49e-03	46	45	2	PS00031
Domain	Znf_hrmn_rcpt	RXRA RXRB	5.49e-03	46	45	2	IPR001628
Domain	Nuclear_hrmn_rcpt	RXRA RXRB	5.49e-03	46	45	2	IPR001723
Domain	ZnF_C4	RXRA RXRB	5.49e-03	46	45	2	SM00399
Domain	NUCLEAR_REC_DBD_2	RXRA RXRB	5.49e-03	46	45	2	PS51030
Domain	-	RXRA RXRB	5.73e-03	47	45	2	1.10.565.10
Domain	EF-hand_1	KCNIP4 PEF1 KCNIP2	5.84e-03	152	45	3	PF00036
Domain	HOLI	RXRA RXRB	5.97e-03	48	45	2	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	RXRA RXRB	5.97e-03	48	45	2	IPR000536
Domain	Hormone_recep	RXRA RXRB	5.97e-03	48	45	2	PF00104
Domain	EFh	KCNIP4 PEF1 KCNIP2	6.50e-03	158	45	3	SM00054
Domain	SOLCAR	MTCH1 SLC25A2	7.23e-03	53	45	2	PS50920
Domain	Mito_carr	MTCH1 SLC25A2	7.23e-03	53	45	2	PF00153
Domain	-	MTCH1 SLC25A2	7.23e-03	53	45	2	1.50.40.10
Domain	Mt_carrier_dom	MTCH1 SLC25A2	7.23e-03	53	45	2	IPR023395
Domain	Mitochondrial_sb/sol_carrier	MTCH1 SLC25A2	7.23e-03	53	45	2	IPR018108
Domain	-	RXRA RXRB	8.33e-03	57	45	2	3.30.50.10
Domain	EF_Hand_1_Ca_BS	KCNIP4 PEF1 KCNIP2	8.60e-03	175	45	3	IPR018247
Domain	Znf_NHR/GATA	RXRA RXRB	8.61e-03	58	45	2	IPR013088
Domain	DH_1	ARHGEF26 PREX2	1.01e-02	63	45	2	PS00741
Domain	RhoGEF	ARHGEF26 PREX2	1.17e-02	68	45	2	SM00325
Pathway	KEGG_MEDICUS_VARIANT_PAX8_PPARG_FUSION_TO_PPARG_MEDIATED_TRANSCRIPTION	RXRA RXRB	4.97e-05	5	32	2	M49023
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_GLUCONEOGENESIS	RXRA RXRB	4.97e-05	5	32	2	M29812
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_LIMIT_CHOLESTEROL_UPTAKE	RXRA RXRB	4.97e-05	5	32	2	M29791
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_TRIGLYCERIDE_LIPOLYSIS_IN_ADIPOSE	RXRA RXRB	4.97e-05	5	32	2	M29792
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_CONTROL_BILE_ACID_HOMEOSTASIS	RXRA RXRB	7.45e-05	6	32	2	MM15663
Pathway	WP_VITAMIN_A1_AND_A5X_PATHWAYS	RXRA RXRB	7.45e-05	6	32	2	M48097
Pathway	REACTOME_PHASE_1_INACTIVATION_OF_FAST_NA_CHANNELS	KCNIP4 KCNIP2	1.04e-04	7	32	2	M27457
Pathway	REACTOME_PHASE_1_INACTIVATION_OF_FAST_NA_CHANNELS	KCNIP4 KCNIP2	1.04e-04	7	32	2	MM15199
Pathway	WP_RETT_SYNDROME	SRRM3 HAP1 SYNE2	1.71e-04	48	32	3	M39759
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_CONTROL_BILE_ACID_HOMEOSTASIS	RXRA RXRB	1.78e-04	9	32	2	M29809
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_LIPOGENESIS	RXRA RXRB	1.78e-04	9	32	2	M29789
Pathway	KEGG_MEDICUS_REFERENCE_THYROID_HORMONE_SIGNALING_PATHWAY	RXRA RXRB	1.78e-04	9	32	2	M47629
Pathway	WP_VITAMIN_D_METABOLISM	RXRA RXRB	2.22e-04	10	32	2	M39352
Pathway	REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING	RXRA RXRB	3.83e-04	13	32	2	MM15622
Pubmed	C-C Motif Chemokine Receptor 9 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction.	A1CF CCR9	1.79e-06	2	47	2	27146447
Pubmed	RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.	RXRA RXRB	1.79e-06	2	47	2	7926783
Pubmed	Effects of metal-binding properties of human Kv channel-interacting proteins on their molecular structure and binding with Kv4.2 channel.	KCNIP4 KCNIP2	1.79e-06	2	47	2	16951992
Pubmed	Retinoid-X-receptors (α/β) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV irradiation.	RXRA RXRB	1.79e-06	2	47	2	24810760
Pubmed	Limited degradation of retinoid X receptor by calpain.	RXRA RXRB	1.79e-06	2	47	2	8780715
Pubmed	Nuclear hormone retinoid X receptor (RXR) negatively regulates the glucose-stimulated insulin secretion of pancreatic ß-cells.	RXRA RXRB	1.79e-06	2	47	2	20798333
Pubmed	Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity.	RXRA RXRB	1.79e-06	2	47	2	22316320
Pubmed	Genetic variant of RXR involved in the vitamin D metabolic pathway was linked to HCV infection outcomes among a high-risk Chinese population.	RXRA RXRB	1.79e-06	2	47	2	33246082
Pubmed	Endogenous retinoid X receptor ligands in mouse hematopoietic cells.	RXRA RXRB	1.79e-06	2	47	2	29089448
Pubmed	Three retinoid X receptor gene polymorphisms in plaque psoriasis and psoriasis guttata.	RXRA RXRB	1.79e-06	2	47	2	17341859
Pubmed	Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.	RXRA RXRB	1.79e-06	2	47	2	16199515
Pubmed	A transcriptionally silent RXRalpha supports early embryonic morphogenesis and heart development.	RXRA RXRB	1.79e-06	2	47	2	19255444
Pubmed	Unique response pathways are established by allosteric interactions among nuclear hormone receptors.	RXRA RXRB	5.36e-06	3	47	2	7758108
Pubmed	Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating.	KCNIP4 KCNIP2	5.36e-06	3	47	2	18957440
Pubmed	The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.	RXRA RXRB	5.36e-06	3	47	2	9727070
Pubmed	Cooperative formation of high-order oligomers by retinoid X receptors: an unexpected mode of DNA recognition.	RXRA RXRB	5.36e-06	3	47	2	7831303
Pubmed	Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma.	RXRA RXRB	5.36e-06	3	47	2	19188585
Pubmed	An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita.	RXRA RXRB	5.36e-06	3	47	2	7990953
Pubmed	Vitamin-D receptor agonist calcitriol reduces calcification in vitro through selective upregulation of SLC20A2 but not SLC20A1 or XPR1.	RXRA RXRB	5.36e-06	3	47	2	27184385
Pubmed	Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.	RXRA RXRB	5.36e-06	3	47	2	1312497
Pubmed	Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription.	RXRA RXRB	5.36e-06	3	47	2	19897601
Pubmed	Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China.	RXRA RXRB	5.36e-06	3	47	2	18375961
Pubmed	Detection of retinoid X receptors using specific monoclonal and polyclonal antibodies.	RXRA RXRB	5.36e-06	3	47	2	7980510
Pubmed	Disruption of both ROCK1 and ROCK2 genes in cardiomyocytes promotes autophagy and reduces cardiac fibrosis during aging.	ROCK1 A1CF	5.36e-06	3	47	2	30848941
Pubmed	Differential regulation of ligand-dependent and ligand-independent functions of the mouse retinoid X receptor beta by alternative splicing.	RXRA RXRB	5.36e-06	3	47	2	10049761
Pubmed	Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate.	RXRA RXRB	5.36e-06	3	47	2	12514092
Pubmed	Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1.	ROCK1 A1CF	5.36e-06	3	47	2	22278938
Pubmed	Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects.	RXRA RXRB	5.36e-06	3	47	2	11053444
Pubmed	Retinoid X receptors: X-ploring their (patho)physiological functions.	RXRA RXRB	5.36e-06	3	47	2	15608692
Pubmed	Chromosomal localization of the human retinoid X receptors.	RXRA RXRB	5.36e-06	3	47	2	8034312
Pubmed	Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells.	ROCK1 FASLG	5.36e-06	3	47	2	18084615
Pubmed	Differential 9-cis-retinoic acid-dependent transcriptional activation by murine retinoid X receptor alpha (RXR alpha) and RXR beta. Role of cell type and RXR domains.	RXRA RXRB	5.36e-06	3	47	2	8631847
Pubmed	Retinoid receptors trigger neuritogenesis in retinal degenerations.	RXRA RXRB	5.36e-06	3	47	2	21940995
Pubmed	The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer.	RXRA RXRB	5.36e-06	3	47	2	11839661
Pubmed	Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles.	RXRA RXRB	5.36e-06	3	47	2	18217139
Pubmed	RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.	RXRA RXRB	5.36e-06	3	47	2	8799145
Pubmed	Differential distribution of KChIPs mRNAs in adult mouse brain.	KCNIP4 KCNIP2	1.07e-05	4	47	2	15363885
Pubmed	Human TAF(II28) promotes transcriptional stimulation by activation function 2 of the retinoid X receptors.	RXRA RXRB	1.07e-05	4	47	2	8670810
Pubmed	Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.	RXRA RXRB	1.07e-05	4	47	2	1310259
Pubmed	Retinoic acid biosynthetic activity and retinoid receptors in the olfactory mucosa of adult mice.	RXRA RXRB	1.07e-05	4	47	2	10079186
Pubmed	Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand.	RXRA RXRB	1.07e-05	4	47	2	8524212
Pubmed	Pregnane X Receptor Expression in Human Pancreatic Adenocarcinoma: Associations With Clinicopathologic Parameters, Tumor Proliferative Capacity, Patients' Survival, and Retinoid X Receptor Expression.	RXRA RXRB	1.07e-05	4	47	2	26355550
Pubmed	Structure, alternative splicing, and expression of the human and mouse KCNIP gene family.	KCNIP4 KCNIP2	1.07e-05	4	47	2	16112838
Pubmed	Retinoids activate RXR/CAR-mediated pathway and induce CYP3A.	RXRA RXRB	1.07e-05	4	47	2	19686701
Pubmed	Retinoid X receptors are essential for early mouse development and placentogenesis.	RXRA RXRB	1.07e-05	4	47	2	9892670
Pubmed	Specific and redundant functions of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells.	RXRA RXRB	1.07e-05	4	47	2	9348290
Pubmed	Specific effects of KChIP3/calsenilin/DREAM, but not KChIPs 1, 2 and 4, on calcium signalling and regulated secretion in PC12 cells.	KCNIP4 KCNIP2	1.07e-05	4	47	2	18393943
Pubmed	Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling.	RXRA RXRB	1.07e-05	4	47	2	25574839
Pubmed	Retinoic X receptor subtypes exert differential effects on the regulation of Trh transcription.	RXRA RXRB	1.07e-05	4	47	2	23896434
Pubmed	The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression.	RXRA RXRB	1.07e-05	4	47	2	10594021
Pubmed	Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis.	RXRA RXRB	1.07e-05	4	47	2	9804293
Pubmed	Sequence and characterization of a coactivator for the steroid hormone receptor superfamily.	RXRA RXRB	1.07e-05	4	47	2	7481822
Pubmed	RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression.	RXRA RXRB	1.07e-05	4	47	2	32246014
Pubmed	The retinoid receptors.	RXRA RXRB	1.07e-05	4	47	2	7967725
Pubmed	Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Müller glial cells.	RXRA RXRB	1.07e-05	4	47	2	10611353
Pubmed	Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity.	RXRA RXRB	1.07e-05	4	47	2	12549917
Pubmed	A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.	RXRA RXRB	1.78e-05	5	47	2	7705655
Pubmed	T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency.	CARD11 FASLG	1.78e-05	5	47	2	20668237
Pubmed	Developmental expression of murine retinoid X receptor (RXR) genes.	RXRA RXRB	1.78e-05	5	47	2	8199055
Pubmed	Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins.	KCNIP4 KCNIP2	1.78e-05	5	47	2	15184042
Pubmed	Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development.	RXRA RXRB	1.78e-05	5	47	2	9053308
Pubmed	Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation.	ROCK1 FASLG	1.78e-05	5	47	2	20379197
Pubmed	Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein.	RXRA RXRB	1.78e-05	5	47	2	1331778
Pubmed	Retinoic acid signaling is necessary for the development of the organ of Corti.	RXRA RXRB	1.78e-05	5	47	2	10452855
Pubmed	Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.	RXRA RXRB	1.78e-05	5	47	2	16880407
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	ROCK1 CCDC88A SLC30A5 UACA TMEM94 COQ5	2.14e-05	421	47	6	36976175
Pubmed	Systematic immunolocalization of retinoid receptors in developing and adult mouse eyes.	RXRA RXRB	2.67e-05	6	47	2	11328745
Pubmed	Similarities and differences in the transcriptional control of expression of the mouse TSLP gene in skin epidermis and intestinal epithelium.	RXRA RXRB	2.67e-05	6	47	2	28115699
Pubmed	Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes.	RXRA RXRB	2.67e-05	6	47	2	16751185
Pubmed	The isolation and characterization of purified heterocomplexes of recombinant retinoic acid receptor and retinoid X receptor ligand binding domains.	RXRA RXRB	2.67e-05	6	47	2	9153406
Pubmed	Spatial distributions of retinoic acid receptor gene transcripts in the prenatal mouse inner ear.	RXRA RXRB	2.67e-05	6	47	2	9548551
Pubmed	Functional specificity of the two retinoic acid receptor RAR and RXR families in myogenesis.	RXRA RXRB	2.67e-05	6	47	2	9464546
Pubmed	Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons.	KCNIP4 KCNIP2	2.67e-05	6	47	2	20943905
Pubmed	Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid.	RXRA RXRB	2.67e-05	6	47	2	20557428
Pubmed	RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells.	RXRA RXRB	2.67e-05	6	47	2	8801169
Pubmed	A decade of molecular biology of retinoic acid receptors.	RXRA RXRB	2.67e-05	6	47	2	8801176
Pubmed	Peroxisome proliferator-activated receptors modulate proliferation and angiogenesis in human endometrial carcinoma.	RXRA RXRB	2.67e-05	6	47	2	22205725
Pubmed	The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development.	RXRA RXRB	2.67e-05	6	47	2	9806918
Pubmed	TGIF inhibits retinoid signaling.	RXRA RXRB	2.67e-05	6	47	2	16428452
Pubmed	Exome sequencing of index patients with retinal dystrophies as a tool for molecular diagnosis.	CHM USH2A	2.67e-05	6	47	2	23940504
Pubmed	A genetic dissection of the retinoid signalling pathway in the mouse.	RXRA RXRB	2.67e-05	6	47	2	10604193
Pubmed	Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors.	RXRA RXRB	2.67e-05	6	47	2	7947324
Pubmed	Effect of retinoid status on the messenger ribonucleic acid expression of nuclear retinoid receptors alpha, beta, and gamma, and retinoid X receptors alpha, beta, and gamma in the mouse testis.	RXRA RXRB	2.67e-05	6	47	2	9075714
Pubmed	Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes.	RXRA RXRB	3.74e-05	7	47	2	9428411
Pubmed	Differential contributions of AF-1 and AF-2 activities to the developmental functions of RXR alpha.	RXRA RXRB	3.74e-05	7	47	2	11493527
Pubmed	Retinoid signaling controls mouse pancreatic exocrine lineage selection through epithelial-mesenchymal interactions.	RXRA RXRB	3.74e-05	7	47	2	12360493
Pubmed	Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors.	RXRA RXRB	3.74e-05	7	47	2	17195188
Pubmed	The structure of the nuclear hormone receptors.	RXRA RXRB	3.74e-05	7	47	2	10406480
Pubmed	Analysis of the factors involved in the retinoic acid-induced differentiation of a retinoid-hypersensitive embryonal carcinoma cell mutant.	RXRA RXRB	3.74e-05	7	47	2	8299717
Pubmed	Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases.	RXRA RXRB	3.74e-05	7	47	2	15635645
Pubmed	Creatine kinase (CK) in skeletal muscle energy metabolism: a study of mouse mutants with graded reduction in muscle CK expression.	RXRA RXRB	3.74e-05	7	47	2	8090775
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	LGMN ROCK1 CCDC88A SLC30A5 UACA TMEM94 PGGT1B	4.80e-05	719	47	7	35337019
Pubmed	Dorsal and ventral rentinoic territories defined by retinoic acid synthesis, break-down and nuclear receptor expression.	RXRA RXRB	4.98e-05	8	47	2	10490294
Pubmed	Expression of nuclear retinoic acid receptors during mouse odontogenesis.	RXRA RXRB	4.98e-05	8	47	2	7988794
Pubmed	Retinoids and adipose tissues: metabolism, cell differentiation and gene expression.	RXRA RXRB	4.98e-05	8	47	2	10094571
Pubmed	Proteomic analyses of native brain K(V)4.2 channel complexes.	KCNIP4 KCNIP2	4.98e-05	8	47	2	19713751
Pubmed	Retinoid X receptor (gamma) is necessary to establish the S-opsin gradient in cone photoreceptors of the developing mouse retina.	RXRA RXRB	4.98e-05	8	47	2	16043864
Pubmed	Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells.	RXRA RXRB	4.98e-05	8	47	2	17124491
Pubmed	Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China.	RXRA RXRB	4.98e-05	8	47	2	19888660
Pubmed	Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.	RXRA RXRB	4.98e-05	8	47	2	29431742
Cytoband	2p16.1	CCDC88A EML6	4.99e-04	32	47	2	2p16.1
GeneFamily	Potassium voltage-gated channel regulatory subunits\|DASH family	KCNIP4 KCNIP2	2.40e-04	15	28	2	858
GeneFamily	Nuclear hormone receptors	RXRA RXRB	2.60e-03	49	28	2	71
GeneFamily	EF-hand domain containing	KCNIP4 PEF1 KCNIP2	4.59e-03	219	28	3	863
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF26 PREX2	4.67e-03	66	28	2	722
GeneFamily	Solute carriers	SLC30A5 MTCH1 SLC25A2	2.26e-02	395	28	3	752
GeneFamily	PDZ domain containing	CARD11 PREX2	2.30e-02	152	28	2	1220
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IFFO2 HK1 PTS CCR9 SPDL1	5.82e-07	153	47	5	5ac4b97d35c1029a5fc625239f92e35136c4d832
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ROCK1 CCDC88A MYH13 USH2A RXRA	1.52e-06	186	47	5	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADHFE1 ARHGEF26 PREX2 EDNRB	2.05e-05	153	47	4	95b28c5bd10ffb74c0993ebd565038b9818e4bd2
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte-Astro\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADHFE1 ARHGEF26 PREX2 EDNRB	2.05e-05	153	47	4	b09f8def40a1ea56722f3398f61a036667b61cd9
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADHFE1 ARHGEF26 PREX2 EDNRB	2.05e-05	153	47	4	3ab9d55b3db51715c1d61eca142384195ce4b54f
ToppCell	frontal_cortex-Non-neuronal-astrocyte-Astro\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADHFE1 ARHGEF26 PREX2 EDNRB	2.26e-05	157	47	4	0551442ae14685d8fe5729e3960c6324b1e05e4d
ToppCell	frontal_cortex-Non-neuronal-astrocyte\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADHFE1 ARHGEF26 PREX2 EDNRB	2.26e-05	157	47	4	803af734d7f775d294391e2b84e472a732e18cef
ToppCell	frontal_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADHFE1 ARHGEF26 PREX2 EDNRB	2.26e-05	157	47	4	9aa5304a9704da6dd4eda7d6940494b00e38b2e8
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LGMN HAP1 RXRA EML6	2.44e-05	160	47	4	0544bc465af208da448858d6e174ff56f2e08a46
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KCNIP4 A1CF CPXM2 SRRM3	3.02e-05	169	47	4	b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCell	E17.5-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell_of_alveolus\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HK1 IMPDH1 USH2A CXorf65	3.70e-05	178	47	4	982205ba117a4c7b7e9b713689a5b69190f0bca9
ToppCell	facs-Marrow-B-cells-18m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARD11 MYH13 CCR9 SYNE2	3.95e-05	181	47	4	e6c78038b14100e0c9c6fe25e8f0b75c02c33549
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNIP4 CARD11 NOL4L RXRA	4.03e-05	182	47	4	3dec003bad0f3716cf8163861a9d4302a7d6df8c
ToppCell	IPF-Lymphoid-ILC_A\|IPF / Disease state, Lineage and Cell class	CRYBG1 CARD11 NOL4L CCR9	4.12e-05	183	47	4	49bfeaae13eb236f61a5486ee75c39789936bb8a
ToppCell	PCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC3_(12)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CRYBG1 CARD11 FASLG CCR9	4.21e-05	184	47	4	3e9d75af578297950e469f23fb2d28393a2feef8
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNIP4 CARD11 NOL4L RXRA	4.30e-05	185	47	4	afbb88325e4a81c15ac1d0a004e3e1f4ba2ee87b
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNIP4 CARD11 NOL4L RXRA	4.30e-05	185	47	4	775b72319ef6acffd2c9a74293b9c1bccea33f42
ToppCell	facs-Trachea-nan-18m-Endothelial-endothelial_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM182 A1CF PREX2 EDNRB	4.67e-05	189	47	4	100eda87ac9c38dddcfa58408b057867a1738acb
ToppCell	IPF-Lymphoid-NK\|IPF / Disease state, Lineage and Cell class	CARD11 NOL4L FASLG SYNE2	4.67e-05	189	47	4	d92e880162450f8d01e4b8784eb625275cb8e03e
ToppCell	Control-Lymphoid-NK\|World / Disease state, Lineage and Cell class	CARD11 NOL4L FASLG SYNE2	4.67e-05	189	47	4	89ef0d0e66dc96cacaae6be7aacdaa884e8e66a8
ToppCell	facs-Trachea-nan-18m-Endothelial\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM182 A1CF PREX2 EDNRB	4.67e-05	189	47	4	5ced78f4b5c276b1bab24df807c00cf5ac8ed3d4
ToppCell	facs-Trachea-nan-18m-Endothelial-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM182 A1CF PREX2 EDNRB	4.67e-05	189	47	4	2105d8b011b93a460237e00bc029efd7762dc8d5
ToppCell	COVID-19-T_cells-NK_cells\|COVID-19 / group, cell type (main and fine annotations)	CARD11 NOL4L FASLG SYNE2	4.67e-05	189	47	4	b699152dfbb8cd8ed724e1e5a51838f29b681b62
ToppCell	facs-SCAT-Fat-3m-Endothelial-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM182 UACA PREX2 EDNRB	4.87e-05	191	47	4	a0018f88f7132477cc467ee15db029a585290595
ToppCell	facs-SCAT-Fat-3m-Endothelial-endothelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM182 UACA PREX2 EDNRB	4.87e-05	191	47	4	6b9bbf4a63d4e9a8075bb06c2aa644fcf4ee88b8
ToppCell	facs-SCAT-Fat-3m-Endothelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM182 UACA PREX2 EDNRB	4.87e-05	191	47	4	90f0c193dce267a4f1a9b2501f636dafd0a34cf7
ToppCell	IPF-Lymphoid-NK\|World / Disease state, Lineage and Cell class	CARD11 NOL4L FASLG SYNE2	4.87e-05	191	47	4	f206159b9d5e84cf14a65bfdc008895cec5a8081
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADHFE1 ARHGEF26 PREX2 EDNRB	4.97e-05	192	47	4	d2161842a38146261847fc9061ba9322e0f087e0
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADHFE1 ARHGEF26 PREX2 EDNRB	4.97e-05	192	47	4	261211a86e6f63b09c2ddce1d2d9257d311f1770
ToppCell	nucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CRYBG1 CARD11 NOL4L SYNE2	5.27e-05	195	47	4	ffb40486f8097b2c08e8f3b3685d0b8cb8d1bc66
ToppCell	nucseq-Immune-Lymphocytic_T/NK\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CRYBG1 CARD11 NOL4L SYNE2	5.27e-05	195	47	4	b8124e8a23e6d37b40023608674e67285c6ffe84
ToppCell	(02)_MMP9/10+-(2)_GFP_FOXI1\|(02)_MMP9/10+ / shred by cell type by condition	CRYBG1 ROCK1 CCDC88A SYNE2	5.71e-05	199	47	4	18a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell	Hematolymphoid-Endothelial-NOSTRIN\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	IMPDH1 UACA PREX2 SYNE2	5.82e-05	200	47	4	032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCell	Hematolymphoid-Endothelial-NOSTRIN---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	IMPDH1 UACA PREX2 SYNE2	5.82e-05	200	47	4	68fce28690246895fd33354b30960ebcc31aa4cc
ToppCell	LPS_only-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	UACA PREX2 EDNRB SYNE2	5.82e-05	200	47	4	81e76508c9050d533853d5fd2f3097b27613d836
ToppCell	Hematolymphoid-Endothelial-NOSTRIN-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	IMPDH1 UACA PREX2 SYNE2	5.82e-05	200	47	4	376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCell	Hematolymphoid-Endothelial-NOSTRIN--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	IMPDH1 UACA PREX2 SYNE2	5.82e-05	200	47	4	7fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCell	Hematolymphoid-Endothelial-NOSTRIN----L2-6\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	IMPDH1 UACA PREX2 SYNE2	5.82e-05	200	47	4	878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCell	Hematolymphoid-Endothelial\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	IMPDH1 UACA PREX2 SYNE2	5.82e-05	200	47	4	7136936d05ab344a560cf159684c881063b5430d
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	UACA PREX2 EDNRB SYNE2	5.82e-05	200	47	4	4bb609a284d4e6066f17470a1736076aa4a1f84c
ToppCell	facs-Thymus-Epithelium-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF26 CCR9 SPDL1	2.13e-04	110	47	3	3a641dced828ed97a8eea70d0a7b76f33630c9be
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-ILC\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CARD11 NOL4L FASLG	2.49e-04	116	47	3	f7f0cd61723c94586504b656a8d4e098e98d8e23
ToppCell	Mild-Myeloid-Macrophages-\|Mild / Condition, Lineage, Cell class and cell subclass	FASLG CXorf65 SYNE2	2.89e-04	122	47	3	b837456a6a236add2c0005cb3ca71568d631014e
ToppCell	facs-Thymus-Epithelium-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF26 CCR9 SPDL1	3.10e-04	125	47	3	6bdbbd47b699d836900bd055f2144cf960b5e7b6
ToppCell	LPS-IL1RA-Endothelial-Epi-like-Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	UACA CCR9 EDNRB	4.15e-04	138	47	3	5f8ac8f67e34a7cf560099208e6884102532391e
ToppCell	343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	KCNIP2 EDNRB SYNE2	4.24e-04	139	47	3	2fdc8f36510aff24abbc79ef2a842db75a85f946
ToppCell	343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	KCNIP2 EDNRB SYNE2	4.24e-04	139	47	3	5970a654c64e3b54f9d18c102f5b125eec892fc5
ToppCell	facs-Lung-3m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CARD11 FASLG CCR9	5.19e-04	149	47	3	efa30fcd9370f98eb7445f295eb4d0305ff455c3
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_D2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KCNIP2 FASLG HAP1	5.39e-04	151	47	3	09405a450af3ea246d9685a6d3137dfaec80e9bf
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells-Ciliated\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CFAP44 USH2A EML6	5.71e-04	154	47	3	9ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CFAP44 USH2A EML6	5.71e-04	154	47	3	58072ce422d09f2de602580325eaac6c4ec6c136
ToppCell	5'-Adult-Appendix-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCDC88A SYNE2 EML6	5.93e-04	156	47	3	203ef22eb76bd2b829b027c30af0557080f4006c
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-dnT\|ICU-NoSEP / Disease, Lineage and Cell Type	FASLG EDNRB SYNE2	6.04e-04	157	47	3	c02500cf9255737c6229ec729803acd568485fb4
ToppCell	facs-Lung-3m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FASLG CXorf65 CCR9	6.27e-04	159	47	3	4750ba9ca06ed97b18df3c74eeb51d3ac8763f63
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOL4L KCNIP2 FASLG	6.27e-04	159	47	3	d2de9391b00b6c47f5fe28a1bad6da2097107ee0
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOL4L KCNIP2 FASLG	6.27e-04	159	47	3	da6b7f8039adc19839d6c090a0b3d68fb6445a79
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FASLG CXorf65 CCR9	6.50e-04	161	47	3	8e787cc7f5e818cad1a6ed143a5fe310993e030b
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-CD8+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FASLG CXorf65 CCR9	6.50e-04	161	47	3	ca9233370490e27b9a1892669d6b82db2136180e
ToppCell	droplet-Liver-Hepatocytes-21m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FASLG USH2A CCR9	6.61e-04	162	47	3	eb2900a250fb3e08e479c727c7d3200cbcf37fbc
ToppCell	droplet-Liver-Hepatocytes-21m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FASLG USH2A CCR9	6.61e-04	162	47	3	1ef3084b5766641ec07c6f488c1756239cf3fd61
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-B_cells-DZ_GC_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCDC88A SYNE2 EML6	6.61e-04	162	47	3	3e15b3e97a2ade86d0cb0ab15fccb9a2e2e27dd4
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel\|Children_(3_yrs) / Lineage, Cell type, age group and donor	A1CF UACA PREX2	6.73e-04	163	47	3	977a970b1296234c22178420294cea73506ee02f
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KCNIP4 A1CF CPXM2	6.85e-04	164	47	3	be49af6335f2505065cde2cb9800e4a5516811b1
ToppCell	Endothelial-endothelial_cell_of_bronchial_vessel\|World / Lineage, Cell type, age group and donor	A1CF UACA PREX2	6.98e-04	165	47	3	84e553d699ac56df89a77248f7308b9133e1b683
ToppCell	droplet-Lung-LUNG-30m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARD11 MYH13 CCR9	7.35e-04	168	47	3	e156297a7515e785a9e79a9676700bd3a9d92b98
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARD11 MYH13 CCR9	7.35e-04	168	47	3	32e0bc0873baa13027241063283ef26d2aab56f5
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IMPDH1 EDNRB SPDL1	7.35e-04	168	47	3	c7021748003e5949f7caf7b3291c5bad294948c1
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CXorf65 CCR9 SPDL1	7.35e-04	168	47	3	a7eb28e15b591997f1aee09501cb20ae18beca08
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell-NK-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CARD11 SYNE2 EML6	7.48e-04	169	47	3	e9c0e0f4c421c7bdbf1a7e33002f3cf22ea307cb
ToppCell	COPD-Lymphoid-ILC_B\|World / Disease state, Lineage and Cell class	CRYBG1 CARD11 NOL4L	7.48e-04	169	47	3	01987c00e0e398eb734613a55e71b4a2b1f0bb21
ToppCell	3'-Adult-SmallIntestine-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CARD11 CCDC88A EML6	7.48e-04	169	47	3	203971cceeba150d0e8891c92662545e84c77837
ToppCell	Smart-seq2-blood_(Smart-seq2)\|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CCDC88A IMPDH1 RXRA	7.48e-04	169	47	3	0ee74cc97a2db9cc16dc73424f74747afe13af90
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CARD11 SYNE2 EML6	7.48e-04	169	47	3	d375a1df1ecc938f66bad92e54b8cda26ca9c472
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell-NK\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CARD11 SYNE2 EML6	7.48e-04	169	47	3	58f805c0be507bd5fadc9ea3555032daabbc8ab8
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CRYBG1 FASLG CCR9	7.48e-04	169	47	3	20b17f1d6d845213479ade09ea0c7ecc277a73c6
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IMPDH1 PREX2 EDNRB	7.61e-04	170	47	3	50c6c571591aa4b218caefe5778c570c809f567e
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IMPDH1 PREX2 EDNRB	7.61e-04	170	47	3	8fe32dcf924d5f6665f7febbc9647d96b1e96f06
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-NK-NK\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FASLG CXorf65 CCR9	7.61e-04	170	47	3	9a47d03f7eea6299a836a0eb1e7c1252c03f76df
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-NK-NK-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FASLG CXorf65 CCR9	7.61e-04	170	47	3	4252c0a335762508bd1f8f71c6e78a657d7df125
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-NK\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FASLG CXorf65 CCR9	7.61e-04	170	47	3	0aa11d8cb44403b6769860dac2d3b05da6fff79d
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IMPDH1 PREX2 EDNRB	7.61e-04	170	47	3	3232db50b1a40f861e981a1b9c9073b81af9f832
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CARD11 CCDC88A SPDL1	7.74e-04	171	47	3	845f312f8cbe29d820da25f0e6d75deb382bbfd8
ToppCell	facs-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FASTKD2 HK1 FASLG	7.74e-04	171	47	3	f1fdc0ec3399ed6955976d02be7e5fc329a64276
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH13 CCR9 SYNE2	7.87e-04	172	47	3	30916a902c151907745756d14327e24adc34afef
ToppCell	droplet-Kidney-nan-18m-Lymphocytic-CD45____T_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNIP2 FASLG CXorf65	7.87e-04	172	47	3	6fc3ba9d20bae9aafe99259a7d705a1741a9294a
ToppCell	droplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CARD11 MYH13 CCR9	8.00e-04	173	47	3	4f0c065e876197ad8cae7856669f09e37ecafa3f
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM182 CARD11 EDNRB	8.00e-04	173	47	3	a2c1ef3f4d7e9f68fc77ee7c42a4727bdea5da94
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM182 CARD11 EDNRB	8.00e-04	173	47	3	4830136f1f1976e00ac9af9062a531ac42533041
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM182 CARD11 EDNRB	8.00e-04	173	47	3	0b79e2a4fd19d524c24b69a6b524ffc6affdabe5
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCDC88A SYNE2 EML6	8.00e-04	173	47	3	b7e0193fd4983cb38d1bee441f608f73ee8743b9
ToppCell	droplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CARD11 MYH13 CCR9	8.00e-04	173	47	3	9bbea566964281f47bf75d665b7d69ba8326e207
ToppCell	E18.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SRRM3 HAP1 EML6	8.13e-04	174	47	3	742c73c9e090848b464323cb17579b86658c6792
ToppCell	E18.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SRRM3 HAP1 EML6	8.13e-04	174	47	3	7fed9722e64c60843092f2ba71256e3043011ef6
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARD11 FASLG CCR9	8.27e-04	175	47	3	a72c6ceca5ddbd34f652e7302defefa2d105e17e
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-CD8+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARD11 FASLG CCR9	8.27e-04	175	47	3	9a462e9e6f7bbb64abb09ad6c080df3576073540
ToppCell	COPD-Lymphoid-ILC_A\|World / Disease state, Lineage and Cell class	CRYBG1 CARD11 NOL4L	8.27e-04	175	47	3	e773e330de36f8a0aa9398a176ed7edb5599c582
ToppCell	facs-Marrow-T_cells-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARD11 CXorf65 CCR9	8.41e-04	176	47	3	74f851a398c7562dd713bc0d8d488c0037243112
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-early_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC30A5 IMPDH1 UACA	8.41e-04	176	47	3	29cda51a99100ddd2928cadc92da40f001d7e1f4
ToppCell	facs-Marrow-T_cells-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARD11 CXorf65 CCR9	8.41e-04	176	47	3	31b5459a978d5cdde0af03a77401e0464d8c95ba
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADHFE1 PREX2 EDNRB	8.41e-04	176	47	3	ac3dc44755280e36c0947b6de3cd639dc17de8b6
Drug	amarantin	LGMN ADHFE1	3.99e-06	2	46	2	CID016048620
Drug	Bexarotene	RXRA RXRB	1.20e-05	3	46	2	DB00307
Drug	2-hydroxyphytanic acid	RXRA RXRB	1.20e-05	3	46	2	ctd:C002585
Drug	AC1O5SBP	RXRA RXRB	1.20e-05	3	46	2	CID006439746
Drug	AGN 190727	RXRA RXRB	2.39e-05	4	46	2	CID006439768
Drug	flavensomycin	ADHFE1 HK1	2.39e-05	4	46	2	CID006444925
Drug	glycidyl acrylate	ADHFE1 HK1	2.39e-05	4	46	2	CID000007836
Drug	iodoacetic acid	LGMN ADHFE1 HK1 PTS	3.89e-05	94	46	4	CID000005239
Drug	7-methoxycitronellal	RXRA RXRB	3.98e-05	5	46	2	CID000019223
Drug	7-methoxycitronellic acid	RXRA RXRB	3.98e-05	5	46	2	CID000171516
Drug	13,14-dihydroretinol	RXRA RXRB	3.98e-05	5	46	2	CID000446798
Drug	dihydroxyacetone	ADHFE1 HK1 CHM PTS	4.58e-05	98	46	4	CID000000670
Drug	AC1Q5S0Y	ROCK1 KCNIP2 FASLG EDNRB	5.57e-05	103	46	4	CID000005650
Drug	Alitretinoin	RXRA RXRB	5.96e-05	6	46	2	DB00523
Drug	Adapalene	RXRA RXRB	5.96e-05	6	46	2	DB00210
Drug	triphenyltin hydroxide	RXRA RXRB	5.96e-05	6	46	2	ctd:C007567
Drug	Methoprene	RXRA RXRB	5.96e-05	6	46	2	ctd:D008726
Drug	Etretinate	RXRA RXRB	5.96e-05	6	46	2	DB00926
Drug	Acitretin	RXRA RXRB	8.33e-05	7	46	2	DB00459
Drug	MGK Repellent 11	ADHFE1 HK1	8.33e-05	7	46	2	CID000031341
Drug	3'-fluoro-3'-deoxyadenosine	ADHFE1 IMPDH1	8.33e-05	7	46	2	CID000122619
Drug	AGN 191659	RXRA RXRB	8.33e-05	7	46	2	CID006366726
Drug	AGN 190121	RXRA RXRB	8.33e-05	7	46	2	CID006441236
Drug	Etretinate-d3	LGMN RXRA RXRB	1.03e-04	45	46	3	CID000003312
Drug	HX 600	RXRA RXRB	1.11e-04	8	46	2	ctd:C104181
Drug	TTNN	RXRA RXRB	1.11e-04	8	46	2	CID000135754
Drug	GGTI-297	ROCK1 PGGT1B	1.11e-04	8	46	2	CID009956145
Drug	2'-deoxy-2'-fluoroadenosine	ADHFE1 IMPDH1	1.11e-04	8	46	2	CID000100253
Drug	AC1O5JP6	RXRA RXRB	1.11e-04	8	46	2	CID006435379
Drug	8-azidoadenine	ADHFE1 HK1	1.42e-04	9	46	2	CID003036161
Drug	tw32	HK1 CHM	1.42e-04	9	46	2	CID000148295
Drug	1 mN-9	HK1 IMPDH1	1.78e-04	10	46	2	CID000122108
Drug	iotrolan	HK1 EDNRB	1.78e-04	10	46	2	CID000003738
Drug	HX 630	RXRA RXRB	1.78e-04	10	46	2	ctd:C422175
Drug	thiocytosine	ADHFE1 HK1	1.78e-04	10	46	2	CID002724245
Drug	diazepinylbenzoic acid	RXRA RXRB	1.78e-04	10	46	2	ctd:C438269
Drug	NSC60597	ADHFE1 PGGT1B RXRA RXRB	1.83e-04	140	46	4	CID000003327
Drug	AGN 191701	RXRA RXRB	2.17e-04	11	46	2	CID006438168
Drug	UVI 3003	RXRA RXRB	2.17e-04	11	46	2	ctd:C525131
Drug	Musk T	RXRA RXRB	2.17e-04	11	46	2	CID000061014
Drug	Histoacryl	VAPA CCDC88A	2.17e-04	11	46	2	CID000023087
Drug	propidium iodide	SLC30A5 FASLG RXRA SYNE2	2.44e-04	151	46	4	CID000004939
Drug	di-n-propylphthalate	RXRA RXRB	2.60e-04	12	46	2	ctd:C106479
Drug	NSC46155	RXRA RXRB	2.60e-04	12	46	2	CID000457869
Disease	retinitis pigmentosa (is_implicated_in)	HK1 IMPDH1 USH2A	3.39e-05	41	45	3	DOID:10584 (is_implicated_in)
Disease	hepatitis B (is_marker_for)	FASLG PREX2	4.69e-04	21	45	2	DOID:2043 (is_marker_for)
Disease	cholangiocarcinoma (is_implicated_in)	FASLG PREX2	5.15e-04	22	45	2	DOID:4947 (is_implicated_in)
Disease	Retinitis Pigmentosa	IMPDH1 CHM USH2A	5.42e-04	104	45	3	C0035334
Disease	smoking status measurement, Cannabis use, schizophrenia	TMEM182 NOL4L	8.99e-04	29	45	2	EFO_0006527, EFO_0007585, MONDO_0005090

Protein segments in the cluster

Peptide	Gene	Start	Entry
MEECKRLQGEMMKLS	VAPA	176	Q9P0L0
DLCEQTGKMKMLFLM	CXorf65	41	A6NEN9
CEKIGKIYEMRMMMD	A1CF	76	Q9NQ94
MTCEMLRKKSGMQIA	EDNRB	296	P24530
NEGARKMERTEMMYT	ARHGEF26	621	Q96DR7
INKVMMFCGMKNGAI	CFAP44	816	Q96MT7
YKEMRQLMKVVNEMC	CPXM2	321	Q8N436
EKRMLMKFLTFCMEY	CHM	291	P24386
SNKMGMQSFSLMKLC	RAD21L1	496	Q9H4I0
KMKACYRRSMSMNDL	CCDC88A	1481	Q3V6T2
MLDIMKAIYDMMGKC	KCNIP4	181	Q6PIL6
MLDIMKSIYDMMGKY	KCNIP2	201	Q9NS61
YLKSCRRMKKNGMEM	NOL4L	241	Q96MY1
GSNACYMEEMKNVEM	HK1	681	P19367
CLMMINMFDKTKSGR	PEF1	156	Q9UBV8
SMMYSGELKFEKRTM	IMPDH1	481	P20839
LREKYMDCGGMLIEM	HAP1	436	P54257
TFMCKVVNSMYKMNF	CCR9	116	P51686
YMEMCSMKRGLDVQM	IFFO2	456	Q5TF58
AKKYDVMNDMMSLGI	COQ5	76	Q5HYK3
GKLETMMCVSYGRME	EML6	861	Q6ZMW3
EMQGFGVMQKTCSMK	CRYBG1	1146	Q9Y4K1
SKMMDAIKGTMTEIY	ZMYND8	931	Q9ULU4
KMRDMQMDKTELGCL	RXRA	356	P19793
KDCEMYKHRMNTVML	CARD11	356	Q9BXL7
MDLKNMGAKNVCLMT	ADHFE1	66	Q8IWW8
ICYMLNNWSGMDMKK	PGGT1B	181	P53609
KETSYEMMMQCVSRM	MTCH1	196	Q9NZJ7
YVCSDKISTGMMMKE	USH2A	3381	O75445
KCMELQEMMEEQGYS	SRRM3	66	A6NNA2
INKQYMMVKSDVCMY	SYNE2	556	Q8WXH0
MMVKSDVCMYRKNIY	SYNE2	561	Q8WXH0
MTAVGQMLDKKMSLC	SPATA31A6	1206	Q5VVP1
LCEHMMREAKIMQYK	FASTKD2	216	Q9NYY8
LDKCRNEMMTMTESY	SPDL1	41	Q96EA4
KCRLQTMYEMEMSGK	SLC25A2	131	Q9BXI2
SKMRDMRMDKTELGC	RXRB	426	P28702
ETMCEMIKIMQEYGE	TMEM94	981	Q12767
CRGYLMRVEFKKMME	MYH13	796	Q9UKX3
VMISEQGEKLYKMMC	PREX2	376	Q70Z35
DLVMMEGKMMSYCTT	FASLG	221	P48023
DFGTCMKMNKEGMVR	ROCK1	216	Q13464
MKMNKEGMVRCDTAV	ROCK1	221	Q13464
KGMYCIGNMQMLAKV	ZNFX1	1226	Q9P2E3
KEDMLLKQGQMYMAD	UACA	391	Q9BZF9
LAMTKQMESMKYCKD	SLC30A5	746	Q8TAD4
DMESYRNMKMKDCLD	TMEM182	176	Q6ZP80
ATGMVMNLADLKKYM	PTS	66	Q03393
KMVFYIEACESGSMM	LGMN	181	Q99538