Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE4A PDE4B PDE4C	9.03e-05	22	80	3	GO:0004115
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE4A PDE4B PDE4C	1.18e-04	24	80	3	GO:0047555
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE4A PDE4B PDE4C	1.34e-04	25	80	3	GO:0004114
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE4A PDE4B PDE4C	1.69e-04	27	80	3	GO:0004112
GeneOntologyMolecularFunction	CoA carboxylase activity	ACACB MCCC1	2.35e-04	6	80	2	GO:0016421
GeneOntologyMolecularFunction	ferroxidase activity	CP HEPH	2.35e-04	6	80	2	GO:0004322
GeneOntologyMolecularFunction	biotin binding	ACACB MCCC1	2.35e-04	6	80	2	GO:0009374
GeneOntologyMolecularFunction	oxidoreductase activity, acting on metal ions, oxygen as acceptor	CP HEPH	2.35e-04	6	80	2	GO:0016724
GeneOntologyMolecularFunction	ligase activity, forming carbon-carbon bonds	ACACB MCCC1	3.29e-04	7	80	2	GO:0016885
GeneOntologyMolecularFunction	racemase and epimerase activity, acting on carbohydrates and derivatives	GNE DSE	8.52e-04	11	80	2	GO:0016857
GeneOntologyBiologicalProcess	cAMP catabolic process	PDE4A PDE4B PDE4C	4.64e-06	9	80	3	GO:0006198
GeneOntologyBiologicalProcess	positive regulation of cytokine production	IFNGR1 TRIM15 CD1D PDE4B ABL2 MBP NAIP ARFGEF2 PRKCQ IL17RA MMP8	1.57e-05	586	80	11	GO:0001819
GeneOntologyBiologicalProcess	cyclic nucleotide catabolic process	PDE4A PDE4B PDE4C	1.98e-05	14	80	3	GO:0009214
GeneOntologyBiologicalProcess	positive regulation of interleukin-2 production	CD1D PDE4B ABL2 PRKCQ	2.10e-05	42	80	4	GO:0032743
GeneOntologyBiologicalProcess	positive regulation of gene expression	IFNGR1 TRIM15 CD1D PDE4B AHI1 ABL2 EGF HGS MBP NAIP ARFGEF2 PABPC1L PRKCQ IL17RA MMP8 KLK3 CNTF	3.20e-05	1446	80	17	GO:0010628
GeneOntologyBiologicalProcess	cAMP metabolic process	PDE4A PDE4B PDE4C	1.22e-04	25	80	3	GO:0046058
Domain	CPSASE_2	CAD ACACB MCCC1	1.56e-06	6	81	3	PS00867
Domain	CPSase_L_D2	CAD ACACB MCCC1	2.72e-06	7	81	3	PF02786
Domain	CbamoylP_synth_lsu-like_ATP-bd	CAD ACACB MCCC1	2.72e-06	7	81	3	IPR005479
Domain	BC-like_N	CAD ACACB MCCC1	2.72e-06	7	81	3	IPR005481
Domain	Biotin_carb_N	CAD ACACB MCCC1	2.72e-06	7	81	3	PF00289
Domain	-	CAD ACACB MCCC1	2.18e-05	13	81	3	3.40.50.20
Domain	ATP-grasp	CAD ACACB MCCC1	2.76e-05	14	81	3	IPR011761
Domain	PreATP-grasp_dom	CAD ACACB MCCC1	2.76e-05	14	81	3	IPR016185
Domain	ATP_GRASP	CAD ACACB MCCC1	2.76e-05	14	81	3	PS50975
Domain	-	CAD ACACB MCCC1	3.44e-05	15	81	3	3.30.1490.20
Domain	MULTICOPPER_OXIDASE2	CP HEPH	5.56e-05	3	81	2	PS00080
Domain	Cu-oxidase	CP HEPH	5.56e-05	3	81	2	PF00394
Domain	Cu-oxidase	CP HEPH	5.56e-05	3	81	2	IPR001117
Domain	ATP_grasp_subdomain_1	CAD ACACB MCCC1	6.12e-05	18	81	3	IPR013815
Domain	-	CAD ACACB MCCC1	6.12e-05	18	81	3	3.30.470.20
Domain	PDEase	PDE4A PDE4B PDE4C	7.24e-05	19	81	3	IPR023088
Domain	PDEase_I	PDE4A PDE4B PDE4C	9.88e-05	21	81	3	PF00233
Domain	PDEASE_I	PDE4A PDE4B PDE4C	9.88e-05	21	81	3	PS00126
Domain	PDEase_CS	PDE4A PDE4B PDE4C	9.88e-05	21	81	3	IPR023174
Domain	Cu-oxidase_2	CP HEPH	1.11e-04	4	81	2	IPR011706
Domain	Cu-oxidase_2	CP HEPH	1.11e-04	4	81	2	PF07731
Domain	-	PDE4A PDE4B PDE4C	1.14e-04	22	81	3	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE4A PDE4B PDE4C	1.31e-04	23	81	3	IPR002073
Domain	HDc	PDE4A PDE4B PDE4C	1.49e-04	24	81	3	SM00471
Domain	HD/PDEase_dom	PDE4A PDE4B PDE4C	1.49e-04	24	81	3	IPR003607
Domain	Cu_oxidase_CS	CP HEPH	1.84e-04	5	81	2	IPR033138
Domain	Biotin_BS	ACACB MCCC1	1.84e-04	5	81	2	IPR001882
Domain	Biotin_carb_C	ACACB MCCC1	1.84e-04	5	81	2	SM00878
Domain	Biotin_carb_C	ACACB MCCC1	1.84e-04	5	81	2	PF02785
Domain	Biotin_carboxylation_dom	ACACB MCCC1	1.84e-04	5	81	2	IPR011764
Domain	CPSASE_1	CAD ACACB	1.84e-04	5	81	2	PS00866
Domain	Cu-oxidase_3	CP HEPH	1.84e-04	5	81	2	IPR011707
Domain	Biotin_COase_C	ACACB MCCC1	1.84e-04	5	81	2	IPR005482
Domain	BIOTIN	ACACB MCCC1	1.84e-04	5	81	2	PS00188
Domain	BC	ACACB MCCC1	1.84e-04	5	81	2	PS50979
Domain	MULTICOPPER_OXIDASE1	CP HEPH	1.84e-04	5	81	2	PS00079
Domain	Cu-oxidase_3	CP HEPH	1.84e-04	5	81	2	PF07732
Domain	Rudment_hybrid_motif	ACACB MCCC1	2.76e-04	6	81	2	IPR011054
Domain	Cu_oxidase_Cu_BS	CP HEPH	2.76e-04	6	81	2	IPR002355
Domain	ATP_grasp_subdomain_2	CAD ACACB MCCC1	3.24e-04	31	81	3	IPR013816
Domain	Biotin_lipoyl	ACACB MCCC1	6.56e-04	9	81	2	PF00364
Domain	Biotin_lipoyl	ACACB MCCC1	8.17e-04	10	81	2	IPR000089
Domain	BIOTINYL_LIPOYL	ACACB MCCC1	8.17e-04	10	81	2	PS50968
Domain	Single_hybrid_motif	ACACB MCCC1	1.19e-03	12	81	2	IPR011053
Domain	-	CP HEPH	1.63e-03	14	81	2	2.60.40.420
Domain	SH3	AHI1 ABL2 MPP4 CASKIN1 MACF1	2.48e-03	216	81	5	PS50002
Domain	ConA-like_dom	TRIM15 FAT1 BSPRY WDFY3 LGALS4	2.63e-03	219	81	5	IPR013320
Domain	SH3_domain	AHI1 ABL2 MPP4 CASKIN1 MACF1	2.69e-03	220	81	5	IPR001452
Domain	-	DNAJC13 RTTN SCYL1 ARFGEF2 WDFY3	2.79e-03	222	81	5	1.25.10.10
Domain	CH	MICAL1 MACF1 UTRN	2.83e-03	65	81	3	SM00033
Domain	CH	MICAL1 MACF1 UTRN	3.49e-03	70	81	3	PF00307
Domain	-	MICAL1 MACF1 UTRN	3.63e-03	71	81	3	1.10.418.10
Domain	CH	MICAL1 MACF1 UTRN	3.93e-03	73	81	3	PS50021
Domain	Cupredoxin	CP HEPH	4.06e-03	22	81	2	IPR008972
Domain	CH-domain	MICAL1 MACF1 UTRN	4.24e-03	75	81	3	IPR001715
Pathway	REACTOME_DARPP_32_EVENTS	PDE4A PDE4B PDE4C	4.57e-05	16	63	3	MM14699
Pathway	REACTOME_METAL_ION_SLC_TRANSPORTERS	CP HEPH SLC39A8	9.19e-05	20	63	3	MM15077
Pathway	WP_SILDENAFIL_TREATMENT	PDE4A PDE4B PDE4C	1.41e-04	23	63	3	M46455
Pathway	REACTOME_METAL_ION_SLC_TRANSPORTERS	CP HEPH SLC39A8	1.61e-04	24	63	3	M18795
Pathway	REACTOME_DARPP_32_EVENTS	PDE4A PDE4B PDE4C	1.61e-04	24	63	3	M751
Pathway	BIOCARTA_EEA1_PATHWAY	EGF HGS	2.91e-04	6	63	2	MM1577
Pathway	BIOCARTA_EEA1_PATHWAY	EGF HGS	4.07e-04	7	63	2	M22064
Pathway	KEGG_MEDICUS_REFERENCE_FE_TF_TRANSPORT	CP SLC39A8	4.07e-04	7	63	2	M47925
Pathway	WP_BIOTIN_METABOLISM_INCLUDING_IMDS	ACACB MCCC1	6.93e-04	9	63	2	M40064
Pathway	WP_G_PROTEIN_SIGNALING_PATHWAYS	PDE4A PDE4B PDE4C PRKCQ	6.94e-04	90	63	4	MM15882
Pathway	WP_G_PROTEIN_SIGNALING	PDE4A PDE4B PDE4C PRKCQ	7.24e-04	91	63	4	M39426
Pubmed	Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.	PDE4A PDE4B PDE4C	5.04e-08	4	82	3	9371714
Pubmed	Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice.	PDE4A PDE4B PDE4C	5.04e-08	4	82	3	34943270
Pubmed	PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.	PDE4A PDE4B PDE4C	5.04e-08	4	82	3	32738081
Pubmed	A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.	PDE4A PDE4B PDE4C	5.04e-08	4	82	3	8413254
Pubmed	Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.	PDE4A PDE4B PDE4C	5.04e-08	4	82	3	22946044
Pubmed	Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.	PDE4A PDE4B PDE4C	5.04e-08	4	82	3	33609559
Pubmed	Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina.	ACO1 CP HEPH	5.04e-08	4	82	3	15354085
Pubmed	Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine.	PDE4A PDE4B PDE4C	5.04e-08	4	82	3	24732776
Pubmed	The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.	PDE4A PDE4B PDE4C	1.26e-07	5	82	3	33944911
Pubmed	A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons.	PDE4A PDE4B PDE4C	1.26e-07	5	82	3	8586960
Pubmed	Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum.	PDE4A PDE4B PDE4C	2.51e-07	6	82	3	18923023
Pubmed	Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels.	CP HEPH SLC39A8	2.51e-07	6	82	3	28057442
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	COL6A3 FAT1 DNAJC13 EGF ACO1 HGS CP IRF6 MBD5 ACE SHROOM2 UTRN G6PD	7.23e-07	1016	82	13	19056867
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	CAD RAB31 TXNDC5 ACO1 MACF1 CP PCNX1 MCCC1 ACE UTRN G6PD	3.07e-06	807	82	11	30575818
Pubmed	Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.	PDE4A PDE4B PDE4C	3.55e-06	13	82	3	8009369
Pubmed	Retinoic acid selectively inhibits death of basal vomeronasal neurons during late stage of neural circuit formation.	VN1R5 PDE4A PDE4B	4.51e-06	14	82	3	19519663
Pubmed	Deletion of hephaestin and ceruloplasmin induces a serious systemic iron deficiency and disrupts iron homeostasis.	CP HEPH	5.49e-06	2	82	2	30060949
Pubmed	Collaborative Interferon-γ and Interleukin-17 Signaling Protects the Oral Mucosa from Staphylococcus aureus.	IFNGR1 IL17RA	5.49e-06	2	82	2	27470712
Pubmed	Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium.	CP HEPH	5.49e-06	2	82	2	22342521
Pubmed	The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration.	CP HEPH	5.49e-06	2	82	2	21051716
Pubmed	Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.	CP HEPH	5.49e-06	2	82	2	26303407
Pubmed	Ablation of hephaestin and ceruloplasmin results in iron accumulation in adipocytes and type 2 diabetes.	CP HEPH	5.49e-06	2	82	2	29355933
Pubmed	Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.	CP HEPH	5.49e-06	2	82	2	27991585
Pubmed	Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.	PDE4B PDE4C	5.49e-06	2	82	2	17727341
Pubmed	Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma.	PDE4A PDE4B	5.49e-06	2	82	2	21047676
Pubmed	Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD.	CP HEPH	5.49e-06	2	82	2	18326691
Pubmed	Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain.	CP HEPH	5.49e-06	2	82	2	25788583
Pubmed	Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration.	CP HEPH	5.49e-06	2	82	2	15365174
Pubmed	Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4.	PDE4A PDE4C	5.49e-06	2	82	2	23043089
Pubmed	Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux.	CP HEPH	5.49e-06	2	82	2	29883959
Pubmed	Genetic Analysis of HIBM Myopathy-Specific GNE V727M Hotspot Mutation Identifies a Novel COL6A3 Allied Gene Signature That Is Also Deregulated in Multiple Neuromuscular Diseases and Myopathies.	COL6A3 GNE	5.49e-06	2	82	2	36980840
Pubmed	Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse.	PDE4A PDE4B	5.49e-06	2	82	2	11267656
Pubmed	Iron induced oxidative damage as a potential factor in age-related macular degeneration: the Cogan Lecture.	CP HEPH	5.49e-06	2	82	2	17065470
Pubmed	Multi-copper ferroxidase deficiency leads to iron accumulation and oxidative damage in astrocytes and oligodendrocytes.	CP HEPH	5.49e-06	2	82	2	31263155
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	MGAM COL6A3 SEMA3C AOC1 TXNDC5 EGF ACO1 CP PABPC1L KLK3 ACE G6PD	7.72e-06	1070	82	12	23533145
Pubmed	Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS.	AOC1 EGF ACE	8.39e-06	17	82	3	21082674
Pubmed	Leukocyte phosphodiesterase expression after lipopolysaccharide and during sepsis and its relationship with HLA-DR expression.	PDE4A PDE4B	1.64e-05	3	82	2	28356347
Pubmed	Reciprocal activation of hypoxia-inducible factor (HIF)-2α and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis.	MTF1 SLC39A8	1.64e-05	3	82	2	26241779
Pubmed	Cerebellar neural stem cells differentiate into two distinct types of astrocytes in response to CNTF and BMP2.	EGF CNTF	1.64e-05	3	82	2	23896528
Pubmed	The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).	PDE4A PDE4B	1.64e-05	3	82	2	24555506
Pubmed	Role of IL-17A on resolution of pulmonary C. neoformans infection.	IFNGR1 IL17RA	1.64e-05	3	82	2	21359196
Pubmed	IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells.	IFNGR1 IL17RA	1.64e-05	3	82	2	20118280
Pubmed	Ferroportin and exocytoplasmic ferroxidase activity are required for brain microvascular endothelial cell iron efflux.	CP HEPH	1.64e-05	3	82	2	23640881
Pubmed	Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.	PDE4A PDE4B	1.64e-05	3	82	2	17404263
Pubmed	Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B.	CD1D PRKCQ	1.64e-05	3	82	2	15067039
Pubmed	Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication.	PDE4A PDE4B	1.64e-05	3	82	2	11114167
Pubmed	Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.	PDE4A PDE4B	1.64e-05	3	82	2	16034090
Pubmed	[Ceruloplasmin, hephaestin and zyklopen: the three multicopper oxidases important for human iron metabolism].	CP HEPH	1.64e-05	3	82	2	24988611
Pubmed	Neither human hephaestin nor ceruloplasmin forms a stable complex with transferrin.	CP HEPH	1.64e-05	3	82	2	18022819
Pubmed	IL-18 skews the invariant NKT-cell population via autoreactive activation in atopic eczema.	IFNGR1 CD1D	1.64e-05	3	82	2	19637196
Pubmed	Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin.	CP HEPH	1.64e-05	3	82	2	30182051
Pubmed	STAT5 proteins are involved in down-regulation of iron regulatory protein 1 gene expression by nitric oxide.	MTF1 ACO1	1.64e-05	3	82	2	16886906
Pubmed	Iron promotes oxidative cell death caused by bisretinoids of retina.	CP HEPH	1.64e-05	3	82	2	29686088
Pubmed	Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation.	PDE4A PDE4B	1.64e-05	3	82	2	15585880
Pubmed	Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-gamma).	IFNGR1 CD1D	1.64e-05	3	82	2	15521020
Pubmed	Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect.	PDE4A PDE4B	1.64e-05	3	82	2	10213096
Pubmed	Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.	PDE4A PDE4B	1.64e-05	3	82	2	18508768
Pubmed	Conditional knockout of hephaestin in the neural retina disrupts retinal iron homeostasis.	CP HEPH	1.64e-05	3	82	2	35271829
Pubmed	Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype.	AHI1 HGS	1.64e-05	3	82	2	20956301
Pubmed	Genomic variants in an inbred mouse model predict mania-like behaviors.	CAD CP UAP1L1	2.16e-05	23	82	3	29768498
Pubmed	Overview of PDEs and their regulation.	PDE4A PDE4B PDE4C	2.80e-05	25	82	3	17307970
Pubmed	Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes.	DNAJC13 HGS	3.28e-05	4	82	2	19874558
Pubmed	Mice with hepcidin-resistant ferroportin accumulate iron in the retina.	CP HEPH	3.28e-05	4	82	2	26506980
Pubmed	T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies.	IFNGR1 IL17RA	3.28e-05	4	82	2	23979161
Pubmed	Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.	PDE4A PDE4B	3.28e-05	4	82	2	21670503
Pubmed	Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.	PDE4A PDE4B	3.28e-05	4	82	2	15644445
Pubmed	SPAK, a STE20/SPS1-related kinase that activates the p38 pathway.	MBP PRKCQ	3.28e-05	4	82	2	10980603
Pubmed	TEIF associated centrosome activity is regulated by EGF/PI3K/Akt signaling.	EGF SCYL1	3.28e-05	4	82	2	24769208
Pubmed	Expression profiling of B cell chronic lymphocytic leukemia suggests deficient CD1-mediated immunity, polarized cytokine response, altered adhesion and increased intracellular protein transport and processing of leukemic cells.	IFNGR1 CD1D	3.28e-05	4	82	2	12454749
Pubmed	IL-17 and IFN-gamma mediate the elicitation of contact hypersensitivity responses by different mechanisms and both are required for optimal responses.	IFNGR1 IL17RA	3.28e-05	4	82	2	19553527
Pubmed	Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases.	PDE4A PDE4B	3.28e-05	4	82	2	23008439
Pubmed	IFN-γ-producing CD4+ T cells promote generation of protective germinal center-derived IgM+ B cell memory against Salmonella Typhi.	IFNGR1 IL17RA	3.28e-05	4	82	2	24778443
Pubmed	Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia.	PDE4A PDE4B	3.28e-05	4	82	2	11839681
Pubmed	Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice.	CP HEPH	3.28e-05	4	82	2	20811044
Pubmed	Cutting edge: IFN-gamma signaling to macrophages is required for optimal Valpha14i NK T/NK cell cross-talk.	IFNGR1 CD1D	5.47e-05	5	82	2	15778340
Pubmed	A high-resolution genetic map of mouse chromosome 19 encompassing the muscle-deficient osteochondrodystrophy (mdf-ocd) region.	SCYL1 CNTF	5.47e-05	5	82	2	9545499
Pubmed	Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.	PDE4A PDE4B	5.47e-05	5	82	2	21652625
Pubmed	Embryonic Poly(A)-Binding Protein (EPAB) Is Required for Granulosa Cell EGF Signaling and Cumulus Expansion in Female Mice.	EGF PABPC1L	5.47e-05	5	82	2	26492470
Pubmed	Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mesoderm.	SIX4 MEOX1	5.47e-05	5	82	2	30807574
Pubmed	Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages.	PDE4A PDE4B	5.47e-05	5	82	2	28383060
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FAT1 PDE4A CLCN7 UCKL1 CASKIN1 ZNF335 RTTN ARFGEF2 PCNX1 WDFY3 MBD5	5.65e-05	1105	82	11	35748872
Pubmed	Expression of nerve-regulated genes in muscles of mouse mutants affected by spinal muscular atrophies and muscular dystrophies.	SCYL1 CNTF	8.19e-05	6	82	2	9040657
Pubmed	Loss of the neurodevelopmental Joubert syndrome causing protein, Ahi1, causes motor and muscle development delays independent of central nervous system involvement.	AHI1 MBP	8.19e-05	6	82	2	30695685
Pubmed	Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures.	ADAMTS20 HEPH	8.19e-05	6	82	2	2289471
Pubmed	Axonal wiring of guanylate cyclase-D-expressing olfactory neurons is dependent on neuropilin 2 and semaphorin 3F.	VN1R5 SEMA3C	8.19e-05	6	82	2	17942483
Pubmed	Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.	COL6A3 TXNDC5 EGF MMP8	8.76e-05	98	82	4	19834535
Pubmed	GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor.	CAD EGF	1.14e-04	7	82	2	14523024
Pubmed	The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.	FKBP10 DNAJC13 CAD GNE ACO1 UAP1L1	1.23e-04	325	82	6	36168628
Pubmed	A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.	PCNX1 IL17RA DSE	1.46e-04	43	82	3	25130324
Pubmed	Discovery and refinement of loci associated with lipid levels.	DNAJC13 AOC1 NPC1L1 PLTP SLC39A8	1.46e-04	211	82	5	24097068
Pubmed	CD1d-restricted IFN-γ-secreting NKT cells promote immune complex-induced acute lung injury by regulating macrophage-inflammatory protein-1α production and activation of macrophages and dendritic cells.	IFNGR1 CD1D	1.52e-04	8	82	2	21191075
Pubmed	A study of genes that may modulate the expression of hereditary hemochromatosis: transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (IRP)-1 and -2, and hepcidin.	ACO1 CP	1.52e-04	8	82	2	11783942
Pubmed	MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota.	IFNGR1 IL17RA	1.96e-04	9	82	2	31542340
Pubmed	Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor.	EGF CNTF	1.96e-04	9	82	2	15051883
Pubmed	Integral and associated lysosomal membrane proteins.	DNAJC13 EGF CLCN7 CP	2.31e-04	126	82	4	17897319
Pubmed	Ephrin-B2 forward signaling regulates somite patterning and neural crest cell development.	EGF MEOX1	2.44e-04	10	82	2	17223098
Pubmed	Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues.	IFNGR1 CD1D	2.44e-04	10	82	2	32647184
Pubmed	Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.	EGF ACE CNTF	2.57e-04	52	82	3	18583979
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	HOXC8 MTF1 BSPRY NAIP MACF1 TACC2 SIX4 MEOX1	2.71e-04	709	82	8	22988430
Pubmed	Molecular cloning, characterization, and genetic mapping of the cDNA coding for a novel secretory protein of mouse. Demonstration of alternative splicing in skin and cartilage.	CD1D EGF	2.98e-04	11	82	2	7608209
GeneFamily	Phosphodiesterases	PDE4A PDE4B PDE4C	3.87e-05	24	50	3	681
Coexpression	ONKEN_UVEAL_MELANOMA_UP	IFNGR1 MICAL1 PDE4A DNAJC13 AHI1 RAB31 ACACB ARFGEF2 MACF1 TACC2 PLTP	3.09e-05	790	81	11	M12490
Coexpression	GSE36888_STAT5_AB_KNOCKIN_VS_WT_TCELL_IL2_TREATED_2H_DN	CD1D SEMA3C CATSPER1 NAIP SCYL1 IL17RA	3.49e-05	198	81	6	M8750
Coexpression	GSE360_HIGH_DOSE_B_MALAYI_VS_M_TUBERCULOSIS_MAC_DN	CD1D PDE4B RAB31 MTF1 ACE SLC39A8	3.59e-05	199	81	6	M5264
Coexpression	GSE11961_MEMORY_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN	IFNGR1 AHI1 ACACB MBP UTRN DSE	3.69e-05	200	81	6	M9368
Coexpression	JOHNSTONE_PARVB_TARGETS_1_DN	COL6A3 FAT1 WDFY3 DSE	4.67e-05	64	81	4	M2237
CoexpressionAtlas	DevelopingGonad_e18.5_epididymis_emap-13166_top-relative-expression-ranked_500	MGAM DNAJC13 HOXC8 ABL2 CP CEP295 WDFY3 UTRN PLTP	2.10e-05	404	80	9	gudmap_developingGonad_e18.5_epididymis_500
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#5_top-relative-expression-ranked_500	MGAM DNAJC13 HOXC8 CEP295 WDFY3 UTRN	2.20e-05	150	80	6	gudmap_developingGonad_e12.5_epididymis_k5_500
CoexpressionAtlas	kidney_adult_Podocyte_MafB_k-means-cluster#4_top-relative-expression-ranked_1000	MGAM EGF WDFY3 KLK3 TMEM9B	6.27e-05	111	80	5	gudmap_kidney_adult_Podocyte_MafB_k4_1000
CoexpressionAtlas	Myeloid Cells, MF.Medl.SLN, CD11b+ CD169+ F4/80+, Lymph Node, avg-2	RAB31 CP WDFY3 MMP8 ACE G6PD PLTP DSE	1.12e-04	391	80	8	GSM854322_500
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_500	MGAM DNAJC13 HOXC8 ABL2 CEP295 WDFY3 UTRN PLTP	1.38e-04	403	80	8	gudmap_developingGonad_e12.5_epididymis_500
CoexpressionAtlas	DevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_500	MGAM DNAJC13 HOXC8 ABL2 CEP295 WDFY3 UTRN PLTP	1.45e-04	406	80	8	gudmap_developingGonad_e16.5_epididymis_500
CoexpressionAtlas	kidney_adult_RenalCortexMixed_Std_k-means-cluster#3_top-relative-expression-ranked_1000	SEMA3C CP SLC39A8	1.58e-04	28	80	3	gudmap_kidney_adult_RenalCortexMixed_Std_k3_1000
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_500	MGAM DNAJC13 HOXC8 ABL2 CEP295 WDFY3 UTRN PLTP	1.63e-04	413	80	8	gudmap_developingGonad_e14.5_ epididymis_500
ToppCell	(0)_Myeloid-(00)_Monocyte-(000)_CD14+_Monocyte\|(00)_Monocyte / immune cells in Peripheral Blood (logTPM normalization)	CD1D PDE4B RAB31 CATSPER1 NAIP IL17RA	6.63e-07	167	82	6	7d9fd6a7a45c2aa0d5f2e3960ca4c97ee8836ba5
ToppCell	356C-Fibroblasts-Fibroblast-H-\|356C / Donor, Lineage, Cell class and subclass (all cells)	FKBP10 COL6A3 HOXC8 MPP4 CUZD1 SIX4	6.86e-07	168	82	6	b5d74500bdac0d680ce7eb7afa0b867b8d85e6a4
ToppCell	356C-Fibroblasts-Fibroblast-H\|356C / Donor, Lineage, Cell class and subclass (all cells)	FKBP10 COL6A3 HOXC8 MPP4 CUZD1 SIX4	6.86e-07	168	82	6	838ce47d4958ba12047882f97925eddd02f081c7
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE4A TXNDC5 BSPRY IRF6 PLTP LGALS4	8.14e-07	173	82	6	0a0cd40bb5f61431fe34758626c8a63ec610a8a5
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 TXNDC5 CP ACE DSE MEOX1	1.24e-06	186	82	6	35c88cc4eb388811fcac4323b549e5897fa8dc27
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 TXNDC5 CP ACE DSE MEOX1	1.24e-06	186	82	6	d998c5b00083cf2a7cd5341a98b7374b4de73c63
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	EGF ACACB PRKCQ WDFY3 MBD5 UTRN	1.36e-06	189	82	6	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	mild-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PDE4B TXNDC5 ACACB ARFGEF2 PABPC1L ACE	1.63e-06	195	82	6	1e5f1967bcc898318f4e970b844b4a944eb168e5
ToppCell	cellseq2-Immune-Immune_Myeloid-iMON-iMON\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CD1D RAB31 CATSPER1 NAIP IL17RA DSE	1.79e-06	198	82	6	a6aa113f0af4d25c032f440c3134fe4d88ca5055
ToppCell	cellseq2-Immune-Immune_Myeloid-iMON\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CD1D RAB31 CATSPER1 NAIP IL17RA DSE	1.79e-06	198	82	6	a0ceed8689d42be6b9cde89d6c182d10b3fb14fc
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FKBP10 COL6A3 SEMA3C FAT1 AHI1 TACC2	1.89e-06	200	82	6	c596a53c0b63c9deaac7d99fcbdd94ecfa96b86c
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FKBP10 COL6A3 SEMA3C FAT1 AHI1 TACC2	1.89e-06	200	82	6	8988f113708eef7d9d2a6a6c1bcfd7c8f9804d3e
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FKBP10 COL6A3 SEMA3C HOXC8 CP PLTP	1.89e-06	200	82	6	3a164e3971bcd62b148b813171c103adb81f972e
ToppCell	droplet-Kidney-nan-24m-Myeloid-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IFNGR1 MBP IL17RA ACE PLTP	1.44e-05	167	82	5	2ee1660be117e20f24557522345572d11cbee813
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IFNGR1 MBP ACE G6PD PLTP	1.61e-05	171	82	5	355a27ea88410a84210f7e4298c7c4f90cf2f8a9
ToppCell	IIH-CD8-naive_CD4\|IIH / Condition, Cell_class and T cell subcluster	CLCN7 GNE ADCK2 MCCC1 MEOX1	1.70e-05	173	82	5	4f2843371d18af766c1892529ce286f56c956fde
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	IFNGR1 MICAL1 SEMA3C RAB31 PLTP	1.75e-05	174	82	5	d77fa525d5c87c190b4a10787b270eabd16c610f
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-lung_macrophage\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RAB31 AOC1 ABL2 PLTP DSE	1.80e-05	175	82	5	f5822cf48777880e670a6a18158ffb31d066c24a
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RAB31 AOC1 ABL2 PLTP DSE	1.80e-05	175	82	5	cddbd42c1cdfcdf2a41d96198ddb20e684ee6317
ToppCell	P03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL6A3 MACF1 CP ACE PLTP	1.80e-05	175	82	5	282f09bbdfa70d93b3f66591dcfb84c5ee0268c7
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RAB31 AOC1 ABL2 PLTP DSE	1.80e-05	175	82	5	067f77c5d9ae3cf960b84ece80c25d5193873cbf
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE4B ABL2 NAIP PLTP DSE	2.29e-05	184	82	5	d1ea2b60fb1ca1a0b809d131310c43903a9e84ce
ToppCell	COPD-Myeloid-cMonocyte\|World / Disease state, Lineage and Cell class	PDE4A PDE4B RAB31 NAIP PCNX1	2.29e-05	184	82	5	ceec41ed5636032aaf7716d1203816ea58bd39bd
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor-Proliferative_AT2_Progenitor\|E16.5-samps / Age Group, Lineage, Cell class and subclass	MICAL1 GNE BSPRY MBP SLC39A8	2.48e-05	187	82	5	e986901f5a1e09cbc9ba37e3c62845ff90ceda95
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FKBP10 COL6A3 SEMA3C FAT1 HEPH	2.48e-05	187	82	5	c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCell	Mesenchymal-myofibroblast_cell\|World / Lineage, Cell type, age group and donor	FKBP10 COL6A3 SEMA3C FAT1 HEPH	2.60e-05	189	82	5	44e37f88137bb249933eb615235b2cf2ae7f3925
ToppCell	Adult\|World / Lineage, Cell type, age group and donor	RAB31 DPP9 EGF TACC2 SLC39A8	2.60e-05	189	82	5	5cd285bfad973125d46d704fec18b21266a63379
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD1D RAB31 NAIP IL17RA DSE	2.67e-05	190	82	5	57800d807785b9d539b47945a0a74631f5e88a06
ToppCell	Fetal_29-31_weeks-Immune-monocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CD1D PDE4A RAB31 NAIP IL17RA	2.67e-05	190	82	5	ad297172a74a80ed5c10f921e15efd1da0fd2d6b
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MICAL1 RAB31 IL17RA WDFY3 MMP8	2.74e-05	191	82	5	d4f77c73311d1149466bbfe4adbd6a301946ec90
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-classical_monocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD1D RAB31 NAIP IL17RA DSE	2.74e-05	191	82	5	1c7d31684654ca6a046d8cc816af1fdc42369c57
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD1D RAB31 NAIP IL17RA DSE	2.74e-05	191	82	5	d60d81d2045c6e624bbc8b17e13a32f7921d969f
ToppCell	renal_papilla_nuclei-Adult_normal_reference\|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	MGAM AOC1 ACACB SHROOM2 UTRN	2.81e-05	192	82	5	6c106b91e46eabbe686a52a65a9c94ad9cbe9390
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FKBP10 COL6A3 SEMA3C TXNDC5 ACE	2.81e-05	192	82	5	beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCell	Mesenchymal_cells-Ng2+_MSCs\|World / Lineage and Cell class	FKBP10 COL6A3 FAT1 CP ACE	2.81e-05	192	82	5	0703b8ec6960ff975ee5a2737054db67cab016b5
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MICAL1 RAB31 IL17RA WDFY3 MMP8	2.88e-05	193	82	5	e1855cff9a6bcfda9188b9fdf6c9d698405da990
ToppCell	RA-08._Macrophage\|World / Chamber and Cluster_Paper	PDE4B RAB31 PCNX1 PLTP SLC39A8	2.88e-05	193	82	5	5fd22db1825d105709fcc0aa4955c99a117e3c82
ToppCell	cellseq-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CD1D PDE4B RAB31 NAIP DSE	2.95e-05	194	82	5	024568d8a862f0fe4da1f66a58c6e71f0e8279f3
ToppCell	moderate-Epithelial-FOXN4+\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	AHI1 RTTN SANBR CEP295 UTRN	2.95e-05	194	82	5	dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD1D PDE4B RAB31 NAIP DSE	3.02e-05	195	82	5	9cfbdb528088ad0ab100c7431c7d8f140a846de8
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD1D PDE4B RAB31 NAIP DSE	3.02e-05	195	82	5	66f3b3e15eaa21bc7cf2f204cac81de1a160a748
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)-DC2_L.1.2.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD1D PDE4B RAB31 NAIP DSE	3.02e-05	195	82	5	bbf5f79be4fcea754328f1af7ee5625075248100
ToppCell	facs-Thymus-Thymus_Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FKBP10 COL6A3 FAT1 CP MEOX1	3.10e-05	196	82	5	6bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCell	facs-Thymus-Thymus_Epithelium-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FKBP10 COL6A3 FAT1 CP MEOX1	3.10e-05	196	82	5	c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE4A PDE4B ABL2 NAIP DSE	3.10e-05	196	82	5	01cea0bb0b938d0986fd2ddae06597b8af1768ee
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE4A PDE4B ABL2 NAIP DSE	3.10e-05	196	82	5	c2bbb48c4aa979b03cb6f4ce9f351f492977c992
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE4A PDE4B ABL2 NAIP DSE	3.10e-05	196	82	5	64c2abc0087bf2ae547932377f3662e3be1cc63e
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_3\|COVID-19_Mild / Disease condition and Cell class	DNAJC13 RAB31 NAIP PCNX1 IL17RA	3.10e-05	196	82	5	f245e929a286cb097130572e1027b4f01be8b04d
ToppCell	COVID-granulo1-\|COVID / Condition, Cell_class and T cell subcluster	IFNGR1 CD1D CATSPER1 NAIP IL17RA	3.18e-05	197	82	5	190392117dc6269a21983bd3e554066fd48acd5e
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IFNGR1 CD1D RAB31 IL17RA DSE	3.18e-05	197	82	5	e2c53742c7d8d1b63d93843f82330b9e20f1faa6
ToppCell	Control_saline-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	FAT1 AHI1 CP UTRN SLC39A8	3.18e-05	197	82	5	44a59dfb889577b3160a5b13ada1276771a00241
ToppCell	IIH-granulo1-\|IIH / Condition, Cell_class and T cell subcluster	IFNGR1 CD1D RAB31 CATSPER1 NAIP	3.18e-05	197	82	5	51be6d5652b17c70f3a33f244efc3b728ec56f5b
ToppCell	COVID-granulo1\|COVID / Condition, Cell_class and T cell subcluster	IFNGR1 CD1D CATSPER1 NAIP IL17RA	3.18e-05	197	82	5	4cd774d9d5a6bf7729dc6b7bcd3ddfe3f3051ada
ToppCell	distal-2-Hematologic-EREG+_Dendritic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CD1D PDE4A PDE4B RAB31 DSE	3.18e-05	197	82	5	6fcca7c071e35786b715adeb18be317d34315d7e
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE4A PDE4B RAB31 SLC39A8 DSE	3.18e-05	197	82	5	59aa4a31674125ae422450aee45db3ced5c405d3
ToppCell	COVID-19\|World / Condition, Lineage and Cell class	NAIP MACF1 UTRN PLTP SLC39A8	3.18e-05	197	82	5	228f641d79282cc3dc51b95a1f4b0cccfc200735
ToppCell	BL\|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MGAM PDE4B NAIP PCNX1 IL17RA	3.18e-05	197	82	5	1acf0191fa0a25cd20bfd9ea7bf727a1555986a1
ToppCell	IIH-granulo1\|IIH / Condition, Cell_class and T cell subcluster	IFNGR1 CD1D RAB31 CATSPER1 NAIP	3.18e-05	197	82	5	39637e8b726bc58c0a6885c49713111f97aff881
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CD1D NAIP IL17RA WDFY3 DSE	3.25e-05	198	82	5	a77f3440d7fb6a50066abc7e9ad59e83798ef13d
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FKBP10 COL6A3 AHI1 MMP8 PLTP	3.25e-05	198	82	5	447d7182edb2cd8a72ebd3c0d16bc6e4ddcaaa5c
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FAT1 AHI1 CP PRKCQ SLC39A8	3.25e-05	198	82	5	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MGAM RAB31 IL17RA WDFY3 MMP8	3.25e-05	198	82	5	df546a9afc0e15398f33c1b511c7281771f9aea0
ToppCell	critical-Epithelial-FOXN4+\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	AHI1 BSPRY RTTN CP CEP295	3.25e-05	198	82	5	6b160b3d6a2c1b1641c2c7dcec1a7ef38411fec9
ToppCell	medial-2-Hematologic-OLR1+_Classical_Monocyte\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PDE4B RAB31 NAIP SLC39A8 DSE	3.25e-05	198	82	5	d0a63cb48deecfdb8902c9229e457b7678aff178
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RAB31 NAIP IL17RA WDFY3 DSE	3.25e-05	198	82	5	d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCell	medial-Hematologic-OLR1+_Classical_Monocyte-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PDE4B RAB31 NAIP SLC39A8 DSE	3.25e-05	198	82	5	74f79fd3b173c236e79b8b8f59a3b7c02ea082c6
ToppCell	medial-Hematologic-OLR1+_Classical_Monocyte\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PDE4B RAB31 NAIP SLC39A8 DSE	3.25e-05	198	82	5	3f21354eb3e5f0949aec21dc2a8940e70464ecc7
ToppCell	mild-HLA-DR-_S100A+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RAB31 NAIP IL17RA WDFY3 DSE	3.33e-05	199	82	5	d0d286eafe935f9b3aaba5b783e8911251121b4a
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RAB31 NAIP IL17RA WDFY3 DSE	3.33e-05	199	82	5	9314eb9a89407738626a0384884454b5f9031ee7
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MGAM RAB31 IL17RA WDFY3 MMP8	3.33e-05	199	82	5	b7af2b4fe6866cc8c78cf0f78390aab1b1b389ba
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABL2 ARFGEF2 UTRN UAP1L1 SLC39A8	3.33e-05	199	82	5	379bbd9cecf466b902411c54d74bd9885285b1ba
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RAB31 NAIP IL17RA WDFY3 DSE	3.33e-05	199	82	5	dbf0bf09896c46155ae6fbd6307f097799e7e34e
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FAT1 AHI1 CP PRKCQ SLC39A8	3.41e-05	200	82	5	e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	FKBP10 SEMA3C FAT1 AHI1 TACC2	3.41e-05	200	82	5	c5e051f1aac8dda376c342a9932785a23450e073
ToppCell	5'-Adult-SmallIntestine-Mesenchymal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FKBP10 COL6A3 HOXC8 CP PLTP	3.41e-05	200	82	5	a637281d91e95734ee4f8510b3780e0272b16fda
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FKBP10 COL6A3 SEMA3C CP PLTP	3.41e-05	200	82	5	6f7f015b5fa1f52374f2c7d9ba339012395eda5f
ToppCell	control-HLA-DR-_S100A+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CD1D SEMA3C RAB31 NAIP IL17RA	3.41e-05	200	82	5	107a0665fb20247511a430178effd7630a619488
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FKBP10 COL6A3 SEMA3C FAT1 TACC2	3.41e-05	200	82	5	87827041663013f5e7273168dc8709d69840e7ce
ToppCell	tumor_Lung-Myeloid_cells-CD163+CD14+_DCs\|tumor_Lung / Location, Cell class and cell subclass	CD1D PDE4B RAB31 ABL2 DSE	3.41e-05	200	82	5	e1f0dfd0f2568e9cecfbb78c19fc25a8a53a76cc
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FKBP10 COL6A3 SEMA3C FAT1 TACC2	3.41e-05	200	82	5	08bf8c00eee6468215edb3611296bfc8784c4d56
ToppCell	mild-Classical_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	IFNGR1 RAB31 NAIP IL17RA DSE	3.41e-05	200	82	5	c8b80d4e7f70c66cbbdd0665821bcd5db69c7d35
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	FKBP10 COL6A3 SEMA3C FAT1 TACC2	3.41e-05	200	82	5	02cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Macroglial\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	FAT1 PDE4B RAB31 TMEM9B PLTP	3.41e-05	200	82	5	46f99bed98da09e6d3f45d4443cbaa6b6c1589bb
ToppCell	Sepsis-ICU-NoSEP-Myeloid-CD14+_Monocyte\|ICU-NoSEP / Disease, condition lineage and cell class	CD1D RAB31 CATSPER1 NAIP IL17RA	3.41e-05	200	82	5	9b91cddf1169a8f6a95bfffcd57d720a2ff57aa2
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Macroglial-Astrocyte\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	FKBP10 FAT1 PDE4B RAB31 CASKIN1	3.41e-05	200	82	5	4fe3b2d80c567c18621bff3341f9a73578c81621
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MGAM RAB31 IL17RA WDFY3 MMP8	3.41e-05	200	82	5	808571d74bb5c4d765ff13fc9393f88020d4e90d
ToppCell	control-HLA-DR-_S100A+_Monocyte\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CD1D RAB31 NAIP IL17RA WDFY3	3.41e-05	200	82	5	9e3e13a68bc1110fa000ec2d80f4c654ddbce17e
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MICAL1 TCAIM CASKIN1 HEPH	7.89e-05	123	82	4	a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SEMA3C FAT1 PRKCQ PLTP	8.14e-05	124	82	4	36dfc702a570e1a1a6dde09f38badf9023ea7287
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NPC1L1 CP PRKCQ SLC39A8	1.07e-04	133	82	4	5bf5e654653e2c340891f51e3f2a30441b7b6b2b
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SEMA3C FAT1 PRKCQ PLTP	1.27e-04	139	82	4	9e9f29f92dbe65b26cc78b3a1c00778c6a701f5b
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1\|Striatum / BrainAtlas - Mouse McCarroll V32	BSPRY MBP PRKCQ TMEM9B	1.45e-04	144	82	4	9d6133558728fa148050eb4f0be33756d71310b0
ToppCell	remission-multiplets\|remission / disease stage, cell group and cell class	CASKIN1 PAQR6 MMP8 QRICH2	1.65e-04	149	82	4	e9974260a5f2999b363f306cae005698c912893a
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MBP CP ACE PLTP	1.78e-04	152	82	4	82a493ffb2f1704cd6f68a82d970fe12f537d20e
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FKBP10 COL6A3 SEMA3C FAT1	2.02e-04	157	82	4	b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	TNNI3K HOXC8 MPP4	2.04e-04	62	82	3	a20620a8869721ea62984c2022ee1b484b455824
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	TNNI3K HOXC8 MPP4	2.04e-04	62	82	3	ee694c06bcd924b4ddf744178ba3a99e04eed51b
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RAB31 PAQR6 IL17RA MMP8	2.22e-04	161	82	4	f5da03c426f3124ea302bd343b6bca81cafee858
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RAB31 PAQR6 IL17RA MMP8	2.28e-04	162	82	4	4e3bf16799c6552366d4c7e42b1328a05dcad7e7
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	MBP MACF1 PCNX1 UTRN	2.28e-04	162	82	4	b4535bcb3f469bc139e73f1122f4070013e5a1de
Drug	Piclamilast	PDE4A PDE4B PDE4C	1.80e-07	4	82	3	DB01791
Drug	selenide ion	MGAM SEMA3C EGF ACO1 MBP CP KLK3 G6PD	2.60e-07	178	82	8	CID000107674
Drug	Ibudilast	PDE4A PDE4B PDE4C	4.48e-07	5	82	3	DB05266
Drug	1,7-naphthyridine	PDE4A PDE4B PDE4C	4.48e-07	5	82	3	CID000009209
Drug	Ketotifen	PDE4A PDE4B PDE4C	1.56e-06	7	82	3	DB00920
Drug	Iloprost	PDE4A PDE4B PDE4C	1.56e-06	7	82	3	DB01088
Drug	Zinc Sulfate	IFNGR1 COL6A3 PDE4A PDE4B EGF ACACB CLCN7 MTF1 CP PABPC1L ACE G6PD CNTF	2.26e-06	739	82	13	ctd:D019287
Drug	Dyphylline	PDE4A PDE4B PDE4C	2.49e-06	8	82	3	DB00651
Drug	trequinsin	PDE4A PDE4B PDE4C	3.72e-06	9	82	3	ctd:C035964
Drug	L-826,141	PDE4A PDE4B PDE4C	3.72e-06	9	82	3	ctd:C459562
Drug	NVP ABE171	PDE4A PDE4B PDE4C	5.31e-06	10	82	3	ctd:C451724
Drug	AC1L1B78	PDE4A PDE4B MTF1 HGS ACE	6.20e-06	72	82	5	CID000001313
Drug	(R)-(+)-Atenolol [56715-13-0]; Down 200; 15uM; PC3; HT_HG-U133A	SEMA3C ACACB CUZD1 IL17RA WDFY3 SHROOM2 UTRN	7.41e-06	198	82	7	4259_DN
Drug	glycerol	MGAM CAD PDE4C ACO1 PAK5 NAIP CP ADCK2 PRKCQ MCCC1 KLK3 ACE G6PD	7.88e-06	829	82	13	CID000000753
Drug	Kiq	MGAM DPP9 G6PD	1.25e-05	13	82	3	CID011974439
Drug	indiganylidynestibane	CP HEPH	1.28e-05	2	82	2	CID003468413
Drug	hydroxyl radicals	MGAM COL6A3 PDE4A PDE4B CAD PDE4C AOC1 EGF GNE ACO1 UCKL1 CP PRKCQ MCCC1 ACE G6PD	1.99e-05	1341	82	16	CID000000961
Drug	Roflumilast	PDE4A PDE4B PDE4C	2.44e-05	16	82	3	ctd:C424423
Drug	miglustat	MGAM CD1D NPC1L1 ACE LGALS4	2.66e-05	97	82	5	CID000051634
Drug	XK234	AOC1 MTF1 ACO1 CP HEPH CNTF	3.14e-05	167	82	6	CID000454923
Drug	felodipine	PDE4A PDE4B PDE4C CATSPER1 EGF ACE	3.36e-05	169	82	6	CID000003333
Drug	Cilomilast	PDE4A PDE4B PDE4C	3.53e-05	18	82	3	ctd:C433247
Drug	4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid	PDE4A PDE4B	3.84e-05	3	82	2	DB08299
Drug	Enprofylline	PDE4A PDE4B	3.84e-05	3	82	2	DB00824
Drug	nicainoprol	KLK3 ACE	3.84e-05	3	82	2	CID000071147
Drug	clinoptilolite	MGAM CP HEPH	4.19e-05	19	82	3	CID006336554
Drug	Edetic Acid	MBP CP MMP8 ACE	4.98e-05	56	82	4	ctd:D004492
Drug	AA-2379	PDE4A PDE4B PDE4C	5.71e-05	21	82	3	CID000128390
Drug	HWA 153	PDE4A PDE4B PDE4C	6.60e-05	22	82	3	CID000162797
Drug	CP-863187 [668981-07-5]; Down 200; 10uM; PC3; HT_HG-U133A	DNAJC13 RAB31 PCNX1 IL17RA SLC39A8 DSE	7.24e-05	194	82	6	7558_DN
Drug	Myricetin [529-44-2]; Down 200; 12.6uM; MCF7; HT_HG-U133A	CLCN7 CUZD1 ADCK2 PRKCQ WDFY3 UTRN	7.45e-05	195	82	6	4170_DN
Drug	Cyclopenthiazide [742-20-1]; Down 200; 10.6uM; PC3; HT_HG-U133A	IFNGR1 EGF CUZD1 PCNX1 SHROOM2 UAP1L1	7.45e-05	195	82	6	4229_DN
Drug	griseolic acid	PDE4A PDE4B PDE4C	7.57e-05	23	82	3	CID000127607
Drug	atherosperminine	PDE4A PDE4B PDE4C	7.57e-05	23	82	3	CID000096918
Drug	silibinin	COL6A3 PDE4A PDE4B PDE4C EGF PRKCQ KLK3	7.63e-05	285	82	7	CID000005213
Drug	NSC612475	EGF ACE	7.65e-05	4	82	2	CID000003412
Drug	2,2'-oxybis(tetrachlorophenol	ACE G6PD	7.65e-05	4	82	2	CID000087732
Drug	methylxylocholine	MGAM KLK3	7.65e-05	4	82	2	CID000009693
Drug	Felbinac [5728-52-9]; Down 200; 18.8uM; MCF7; HT_HG-U133A	FKBP10 AHI1 ADCK2 PCNX1 WDFY3 UTRN	7.67e-05	196	82	6	5700_DN
Drug	Diphemanil methylsulfate [62-97-5]; Down 200; 10.2uM; MCF7; HT_HG-U133A	MICAL1 AHI1 CUZD1 PCNX1 TEAD3 LGALS4	7.67e-05	196	82	6	4416_DN
Drug	(R)-Propranolol hydrochloride [13071-11-9]; Down 200; 13.6uM; HL60; HT_HG-U133A	CD1D PDE4B ACO1 PCNX1 PAQR6 G6PD	7.67e-05	196	82	6	6130_DN
Drug	Delcorine; Down 200; 8.4uM; MCF7; HT_HG-U133A	MICAL1 HOXC8 ACACB CLCN7 PCNX1 WDFY3	7.67e-05	196	82	6	3613_DN
Drug	Panthenol (D) [81-13-0]; Up 200; 19.4uM; PC3; HT_HG-U133A	IFNGR1 FKBP10 EGF ACACB PCNX1 UTRN	7.89e-05	197	82	6	1802_UP
Drug	Saquinavir mesylate [149845-06-7]; Down 200; 5.2uM; PC3; HT_HG-U133A	FKBP10 EGF PCNX1 PAQR6 TEAD3 UAP1L1	7.89e-05	197	82	6	5770_DN
Drug	Adenosine 5'-monophosphate monohydrate [18422-05-4]; Up 200; 11uM; MCF7; HT_HG-U133A	AOC1 ACACB NPC1L1 PCNX1 IL17RA WDFY3	8.11e-05	198	82	6	3237_UP
Drug	Cefadroxil [50370-12-2]; Down 200; 11uM; PC3; HT_HG-U133A	MICAL1 RAB31 HOXC8 MTF1 ADAMTS20 UAP1L1	8.11e-05	198	82	6	4080_DN
Drug	Dilazep dihydrochloride [20153-98-4]; Up 200; 6uM; MCF7; HT_HG-U133A	PDE4B PDE4C ACACB PCNX1 UTRN PLTP	8.11e-05	198	82	6	2294_UP
Drug	Dipyrone [5907-38-0]; Up 200; 12uM; MCF7; HT_HG-U133A	MICAL1 PDE4A MBP ADAMTS20 ADCK2 MMP8	8.11e-05	198	82	6	3929_UP
Drug	nordihydroguaiaretic acid; Up 200; 1uM; MCF7; HT_HG-U133A	HOXC8 ABL2 EGF ACACB ADCK2 IL17RA	8.11e-05	198	82	6	5220_UP
Drug	Betahistine mesylate [54856-23-4]; Up 200; 17.2uM; MCF7; HT_HG-U133A	AHI1 PDE4C HOXC8 CLCN7 PCNX1 UTRN	8.11e-05	198	82	6	4956_UP
Drug	D-cycloserine [68-41-7]; Up 200; 39.2uM; PC3; HT_HG-U133A	RAB31 EGF BSPRY PCNX1 WDFY3 UTRN	8.34e-05	199	82	6	7134_UP
Drug	Papaverine hydrochloride [61-25-6]; Down 200; 10.6uM; PC3; HT_HG-U133A	RAB31 HOXC8 ABL2 ACACB UTRN UAP1L1	8.34e-05	199	82	6	5769_DN
Drug	aldosterone	CATSPER1 EGF HGS PRKCQ MMP8 KLK3 ACE G6PD	9.21e-05	397	82	8	CID000005839
Drug	Vancomycin	IFNGR1 MGAM COL6A3 SEMA3C AOC1 EGF BSPRY NPC1L1 CP TACC2 MCCC1 SLC39A8	9.35e-05	906	82	12	ctd:D014640
Drug	desethyl KBT-3022	PDE4A PDE4B PDE4C	1.10e-04	26	82	3	CID000127736
Drug	T-440	PDE4A PDE4B PDE4C	1.10e-04	26	82	3	CID000177965
Drug	Ro 15-2041	PDE4A PDE4B PDE4C	1.10e-04	26	82	3	CID000132434
Drug	vanadyl	MGAM PDE4A PDE4B PDE4C EGF MBP G6PD	1.21e-04	307	82	7	CID000061671
Drug	D-22888	PDE4A PDE4B	1.27e-04	5	82	2	CID000197714
Drug	PCB 167	MGAM EGF	1.27e-04	5	82	2	CID000040479
Drug	AC1NQPMN	MGAM CP	1.27e-04	5	82	2	CID005276919
Drug	tetrachlorophene	ACE G6PD	1.27e-04	5	82	2	CID000016023
Drug	ngml	MGAM KLK3	1.27e-04	5	82	2	CID000066936
Drug	DIPSO	EGF ACE	1.27e-04	5	82	2	CID000100210
Drug	FQp	CP ACE	1.27e-04	5	82	2	CID000001722
Drug	phosphogypsum	MGAM ZNF335 HGS	1.38e-04	28	82	3	CID000024928
Drug	ferrous ammonium sulfate	ACO1 CP HEPH	1.38e-04	28	82	3	CID000024863
Drug	DL-penicillamine	COL6A3 CP WDFY3 ACE CNTF	1.48e-04	139	82	5	CID000004727
Drug	AC1L1BEB	GNE KLK3 G6PD	1.70e-04	30	82	3	CID000001402
Drug	4-n-heptylphenol	KLK3 G6PD	1.90e-04	6	82	2	CID000016143
Drug	P0-305	AOC1 ACE	1.90e-04	6	82	2	CID000006778
Drug	pentachloropyridine	MBP CP	1.90e-04	6	82	2	CID000016584
Drug	Pentoxifylline	PDE4A PDE4B	1.90e-04	6	82	2	DB00806
Drug	AC1Q6KW6	MGAM CP	1.90e-04	6	82	2	CID000189049
Drug	4-n-hexylphenol	KLK3 G6PD	1.90e-04	6	82	2	CID000017132
Drug	imidazole-4-carboxamide	PDE4A PDE4B PDE4C	2.07e-04	32	82	3	CID000152917
Drug	Diethylstilbestrol	IFNGR1 COL6A3 CD1D HOXC8 AOC1 EGF ACO1 BSPRY CASKIN1 CUZD1 CP KLK3 SLC39A8 MEOX1	2.17e-04	1305	82	14	ctd:D004054
Drug	dyphylline	PDE4A PDE4B PDE4C	2.27e-04	33	82	3	CID000003182
Drug	Fructose	EGF ACACB CP PRKCQ ACE G6PD	2.64e-04	246	82	6	ctd:D005632
Drug	Theophylline	PDE4A PDE4B	2.66e-04	7	82	2	DB00277
Drug	nitraquazone	MGAM PDE4B	2.66e-04	7	82	2	CID000068765
Drug	VAL-TRP	MGAM ACE	2.66e-04	7	82	2	CID000168182
Drug	Cp52	MBP CP	2.66e-04	7	82	2	CID003077062
Disease	Autistic Disorder	PDE4A PDE4B AHI1 EGF MTF1 CP HTR3C ACE	5.63e-07	261	80	8	C0004352
Disease	HDL cholesterol change measurement, physical activity	SEMA3C RBM6 PLTP SLC39A8	2.48e-05	62	80	4	EFO_0003940, EFO_0007805
Disease	vital capacity	IFNGR1 MICAL1 COL6A3 AHI1 AOC1 MTF1 HGS ARFGEF2 MCCC1 SIX4 UTRN SLC39A8	1.20e-04	1236	80	12	EFO_0004312
Disease	sexual dimorphism measurement	MGAM CATSPER1 AOC1 CASKIN1 ZNF335 RBM6 MACF1 TEAD3 PLTP SLC39A8 DSE	1.92e-04	1106	80	11	EFO_0021796
Disease	loneliness measurement	ARFGEF2 MACF1 MBD5 UTRN	3.67e-04	124	80	4	EFO_0007865
Disease	triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	ZNF335 NPC1L1 MACF1 PLTP SLC39A8	3.72e-04	225	80	5	EFO_0008317, EFO_0020947
Disease	schizophrenia, gastroesophageal reflux disease	PDE4B SLC39A8	3.93e-04	11	80	2	EFO_0003948, MONDO_0005090
Disease	uveitis (is_marker_for)	IFNGR1 ACE	5.55e-04	13	80	2	DOID:13141 (is_marker_for)
Disease	cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement	NPC1L1 MACF1 PLTP SLC39A8	6.45e-04	144	80	4	EFO_0004611, EFO_0020943
Disease	anemia (is_implicated_in)	ACE G6PD	6.47e-04	14	80	2	DOID:2355 (is_implicated_in)
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	MACF1 PLTP SLC39A8	8.11e-04	67	80	3	EFO_0008595, EFO_0020946
Disease	metabolite measurement	SEMA3C AOC1 MCCC1 ACE SHROOM2 G6PD PLTP	8.21e-04	560	80	7	EFO_0004725
Disease	ovarian cancer (is_marker_for)	EGF MMP8 UTRN	8.47e-04	68	80	3	DOID:2394 (is_marker_for)
Disease	Pre-Eclampsia	CP ACE	8.50e-04	16	80	2	C0032914
Disease	autism spectrum disorder (is_implicated_in)	AHI1 MBD5	8.50e-04	16	80	2	DOID:0060041 (is_implicated_in)
Disease	erythrocyte cadmium measurement	MBP SLC39A8	9.61e-04	17	80	2	EFO_0007807
Disease	theta wave measurement	MBP SLC39A8	9.61e-04	17	80	2	EFO_0006873
Disease	type 1 diabetes mellitus (is_marker_for)	CP ACE G6PD	1.00e-03	72	80	3	DOID:9744 (is_marker_for)
Disease	alcohol consumption measurement, high density lipoprotein cholesterol measurement	SEMA3C RBM6 PLTP SLC39A8	1.00e-03	162	80	4	EFO_0004612, EFO_0007878
Disease	free cholesterol to total lipids in large LDL percentage	MACF1 PLTP SLC39A8	1.08e-03	74	80	3	EFO_0022280
Disease	alcohol drinking, high density lipoprotein cholesterol measurement	SEMA3C RBM6 PLTP SLC39A8	1.15e-03	168	80	4	EFO_0004329, EFO_0004612
Disease	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	ACACB NPC1L1 MACF1 PLTP SLC39A8	1.19e-03	291	80	5	EFO_0008317, EFO_0020946
Disease	gamma-aminoisobutyric acid measurement	AOC1 TACC2	1.20e-03	19	80	2	EFO_0010482
Disease	osteoporosis (implicated_via_orthology)	IFNGR1 ACE	1.20e-03	19	80	2	DOID:11476 (implicated_via_orthology)
Disease	renovascular hypertension (biomarker_via_orthology)	ACE G6PD	1.20e-03	19	80	2	DOID:1591 (biomarker_via_orthology)
Disease	Retinal Degeneration	AHI1 CP	1.47e-03	21	80	2	C0035304
Disease	alkaline phosphatase measurement	DNAJC13 PDE4C AOC1 ACACB UCKL1 CASKIN1 MACF1 UTRN PLTP	1.70e-03	1015	80	9	EFO_0004533
Disease	nephrotic syndrome (implicated_via_orthology)	FAT1 ACE	1.93e-03	24	80	2	DOID:1184 (implicated_via_orthology)
Disease	Albuminuria	CP ACE	1.93e-03	24	80	2	C0001925
Disease	peripheral arterial disease, traffic air pollution measurement	AHI1 MACF1 MBD5 UTRN	1.94e-03	194	80	4	EFO_0004265, EFO_0007908
Disease	multisite chronic pain	AOC1 UTRN SLC39A8	2.22e-03	95	80	3	EFO_0010100
Disease	Adenocarcinoma of large intestine	TNNI3K PAK5 PRKCQ	2.29e-03	96	80	3	C1319315
Disease	Cerebral Hemorrhage	ACE CNTF	2.62e-03	28	80	2	C2937358
Disease	gastroesophageal reflux disease	PDE4B RBM6 SLC39A8	2.64e-03	101	80	3	EFO_0003948
Disease	Schizophrenia	PDE4A PDE4B AHI1 TXNDC5 MBP CP ACE CNTF	2.70e-03	883	80	8	C0036341

Protein segments in the cluster

Peptide	Gene	Start	Entry
NVFSVIPEEFPNFHH	NAIP	1116	Q13075
GFQVAPEHHNDHKTF	ACO1	401	P21399
HNVHPFAQEFINEVG	BHLHB9	351	Q6PI77
IFVDNFVHADLHPGN	ADCK2	436	Q7Z695
SHVGHTGVFFFVDQD	AGPAT4-IT1	101	Q9H0P7
ESHHPPEFQDFHDQA	CATSPER1	56	Q8NEC5
QHADGFSFTPAQQEA	ABL2	696	P42684
THFDAGAKFHVPNVT	ACE	511	P12821
PHQGSFQIDEFVHTE	AHI1	956	Q8N157
FAVFHQAASDHDGNI	ARFGEF2	1226	Q9Y6D5
FQHHFPAAIDSFQDA	ARFGEF2	1256	Q9Y6D5
DQHGVDPAVFQAVFD	HTR3C	36	Q8WXA8
IFFGDQEHPNVTEFA	AOC1	101	P19801
ERVNEFGEVFPQSHH	ADAMTS20	46	P59510
FGEVFPQSHHFSRQK	ADAMTS20	51	P59510
AVFQQEHFFHVFSGP	MMP8	426	P22894
VQDHFDHNISPTIGA	RAB31	26	Q13636
DQVYPDAAQHGHAFS	QRICH2	921	Q9H0J4
FQGDAFHQSDTHIFI	G6PD	21	P11413
QEEHIFTEQHPAFPQ	MEOX1	76	P50221
VVGQDPGSDVAFHFN	LGALS4	51	P56470
HQVAVQFADFHDTPG	ACACB	2291	O00763
EVDVHAAFFHGQALT	CP	291	P00450
NFEHRVHTGFDPQEQ	PAK5	16	Q9P286
NHVPFAIDHFTGAVS	FAT1	506	Q14517
NVNFQDPDGFSALHH	CASKIN1	41	Q8WXD9
HFAHTQQGDLFPVAH	IL17RA	81	Q96F46
QSPFHGQDEEELFHS	PRKCQ	576	Q04759
EVPHEHVQSFSGNAA	MGAM	196	O43451
SNHNGFPVVEHADDT	CLCN7	656	P51798
AFHAFAQPFAVPHSA	PCNX1	1471	Q96RV3
GINFVHEVVTNHAGF	PLTP	441	P55058
AIHDVDHPGVSNQFL	PDE4A	471	P27815
FAAAIHDVDHPGVSN	PDE4B	441	Q07343
AIHDVDHPGVSNQFL	PDE4C	426	Q08493
FGQFFDHVIVNDSLH	MPP4	591	Q96JB8
PAHFHRNFPEQVFQD	MACF1	736	O94854
FNAGHEHPDQNSFTF	DSE	446	Q9UL01
FAQDAHGQPDVSAFD	MICAL1	351	Q8TDZ2
GHLHQFFVPAAALNS	PAQR6	146	Q6TCH4
GFVHFETHEAAQQAI	PABPC1L	141	Q4VXU2
FHDQHFGPFFRTNQV	NPC1L1	396	Q9UHC9
FNVHVIDFHNPADVV	FKBP10	366	Q96AY3
DQEFRFSHNGQHEPL	BSPRY	331	Q5W0U4
HVPFDQFIQLVAHAG	GNE	281	Q9Y223
QNDVGHPFAVAVFED	EGF	681	P01133
EVHPGNASNNFFHVA	CD1D	121	P15813
FQFVQKTDESGPHSH	DPP9	56	Q86TI2
VHFTPTEGDFHQAIH	CNTF	96	P26441
FHFALVQFNGNPHTE	COL6A3	76	P12111
NPEAAVHIFEGTHEN	DNAJC13	1911	O75165
HPEFEAGNVHTDFIP	MCCC1	476	Q96RQ3
HGRTQDENPVVHFFK	MBP	211	P02686
GSDFPFVGQEHALHF	MBD5	886	Q9P267
APGFQHASHHVQDFF	HOXC8	46	P31273
GFQHETHAEETPNQP	CUZD1	551	Q86UP6
QPDTNLAHVGAHSFA	CEP295	2146	Q9C0D2
FHPSVFVNGDEQEVD	IFNGR1	146	P15260
DQSQHHVPIQDTFPF	IRF6	151	O14896
LPEASHDQFVAQGHQ	RTTN	1571	Q86VV8
HDQFVAQGHQESTSP	RTTN	1576	Q86VV8
QEAHRDFGPSSQHFL	UTRN	2796	P46939
GVAFEHESPADFQNS	RBM6	346	P78332
FAVHPDFFGQHPVER	TCAIM	41	Q8N3R3
HLSDIQTVFNGPFAH	SEMA3C	341	Q99985
NTQIFPHVVHGFLDT	SCYL1	386	Q96KG9
PVPHSTQFAANHQEF	MTF1	471	Q14872
RGHHTDVANIFPATF	HEPH	316	Q9BQS7
VGHPSPAVHQDFVQE	SIX4	696	Q9UIU6
QGPVFSEAAAAQHFT	SHROOM2	336	Q13796
HGEFQETPVGHDAVS	SANBR	96	Q6NSI8
IGDHQPFANAHDVLA	TMEM9B	146	Q9NQ34
GPAAVEAVNVFHHLF	WDFY3	2921	Q8IZQ1
HLFVHIGQTNPAFSD	TEAD3	246	Q99594
HQAHTVGFLDEAIQP	TRIM15	111	Q9C019
FSEPQFHNGESEESH	HGS	391	O14964
FREHNFFHLDPANVV	UAP1L1	181	Q3KQV9
AFQVAPHSHGEEAVA	TACC2	1576	O95359
NSLPFFSVQFHPEHQ	CAD	326	P27708
FSVQFHPEHQAGPSD	CAD	331	P27708
HPQETVFHTNDFEGC	VN1R5	211	Q7Z5H4
QAAHNNFNFDHPDAF	UCKL1	146	Q9NWZ5
ASNFELHVAQGDHFI	TXNDC5	196	Q8NBS9
AVTEANGHIHFDNVS	SLC39A8	261	Q9C0K1
HGANVNIQDAVFFTP	TNNI3K	156	Q59H18
RFHVNSHEAGDPQLF	ZNF335	481	Q9H4Z2
FHPEDTGQVFQVSHS	KLK3	81	P07288