Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH5 DNAH8 DNAH14 DNAH11

5.40e-0718754GO:0008569
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH5 DNAH8 DNAH14 DNAH11

3.51e-0628754GO:0051959
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH5 DNAH8 DNAH14 DNAH11

1.10e-0537754GO:0045505
GeneOntologyMolecularFunctionmicrotubule motor activity

DNAH5 DNAH8 DNAH14 DNAH11

1.40e-0470754GO:0003777
GeneOntologyCellularComponentcyclin E1-CDK2 complex

CCNE1 CCNE2

3.70e-053742GO:0097134
GeneOntologyCellularComponentdynein complex

DNAH5 DNAH8 DNAH14 DNAH11

4.00e-0554744GO:0030286
GeneOntologyCellularComponent9+0 motile cilium

DNAH5 DNAH11

1.84e-046742GO:0097728
GeneOntologyCellularComponentendoplasmic reticulum membrane

MIA2 MCTP1 SBF1 OR7A5 ABHD12B TUSC3 AGMO UGT2B4 UGT2B7 ATP11A GNAI3 TMEM41B TXNDC11

5.57e-0412937413GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

MIA2 MCTP1 SBF1 OR7A5 ABHD12B TUSC3 AGMO UGT2B4 UGT2B7 ATP11A GNAI3 TMEM41B TXNDC11

5.82e-0412997413GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

MIA2 MCTP1 SBF1 OR7A5 ABHD12B TUSC3 AGMO UGT2B4 UGT2B7 ATP11A GNAI3 TMEM41B TXNDC11

7.11e-0413277413GO:0042175
GeneOntologyCellularComponentouter dynein arm

DNAH5 DNAH8

7.97e-0412742GO:0036157
GeneOntologyCellularComponentaxoneme

WDR35 AKAP14 DNAH5 DNAH8 DNAH11

8.40e-04207745GO:0005930
GeneOntologyCellularComponentciliary plasm

WDR35 AKAP14 DNAH5 DNAH8 DNAH11

8.58e-04208745GO:0097014
GeneOntologyCellularComponentcyclin-dependent protein kinase holoenzyme complex

CCNE1 CCNE2 BCCIP

1.32e-0361743GO:0000307
GeneOntologyCellularComponent9+2 motile cilium

AKAP14 DNAH5 DNAH8 DNAH14 DNAH11

1.56e-03238745GO:0097729
MousePhenobiventricular, ambiguous atrioventricular connection

DNAH5 DNAH11

1.36e-052522MP:0011511
MousePhenobiventricular, discordant atrioventricular connection

DNAH5 DNAH11

4.06e-053522MP:0011510
DomainDynein_heavy_chain_D4_dom

DNAH5 DNAH8 DNAH14 DNAH11

2.21e-0714744IPR024317
DomainDynein_HC_stalk

DNAH5 DNAH8 DNAH14 DNAH11

2.21e-0714744IPR024743
DomainMT

DNAH5 DNAH8 DNAH14 DNAH11

2.21e-0714744PF12777
DomainAAA_8

DNAH5 DNAH8 DNAH14 DNAH11

2.21e-0714744PF12780
DomainDHC_fam

DNAH5 DNAH8 DNAH14 DNAH11

3.00e-0715744IPR026983
DomainDynein_heavy_dom

DNAH5 DNAH8 DNAH14 DNAH11

3.00e-0715744IPR004273
DomainDynein_heavy

DNAH5 DNAH8 DNAH14 DNAH11

3.00e-0715744PF03028
DomainDHC_N1

DNAH5 DNAH8 DNAH11

3.30e-068743PF08385
DomainDynein_heavy_dom-1

DNAH5 DNAH8 DNAH11

3.30e-068743IPR013594
DomainCyclin_E

CCNE1 CCNE2

1.55e-052742IPR028858
DomainDynein_heavy_dom-2

DNAH5 DNAH8 DNAH11

2.11e-0514743IPR013602
DomainDHC_N2

DNAH5 DNAH8 DNAH11

2.11e-0514743PF08393
DomainATPase_dyneun-rel_AAA

DNAH5 DNAH8 DNAH11

2.11e-0514743IPR011704
DomainAAA_5

DNAH5 DNAH8 DNAH11

2.11e-0514743PF07728
DomainUDENN

DENND5B SBF1 DENND4C

3.22e-0516743PS50946
DomainDDENN

DENND5B SBF1 DENND4C

3.22e-0516743PS50947
DomainDENN

DENND5B SBF1 DENND4C

3.22e-0516743SM00799
DomaindDENN

DENND5B SBF1 DENND4C

3.22e-0516743SM00801
DomainDENN

DENND5B SBF1 DENND4C

3.22e-0516743PF02141
DomaindDENN_dom

DENND5B SBF1 DENND4C

3.22e-0516743IPR005112
DomainuDENN_dom

DENND5B SBF1 DENND4C

3.22e-0516743IPR005113
DomaindDENN

DENND5B SBF1 DENND4C

3.22e-0516743PF03455
DomainDENN

DENND5B SBF1 DENND4C

3.22e-0516743PS50211
DomainDENN_dom

DENND5B SBF1 DENND4C

3.22e-0516743IPR001194
DomainuDENN

DENND5B SBF1

1.37e-0314742SM00800
DomainuDENN

DENND5B SBF1

1.57e-0315742PF03456
DomainPI3/4_kinase_CS

PI4KA ATM

1.57e-0315742IPR018936
Domain-

PI4KA ATM

1.79e-03167421.10.1070.11
DomainPI3Kc

PI4KA ATM

1.79e-0316742SM00146
DomainCyclin_C

CCNE1 CCNE2

2.03e-0317742PF02984
DomainCyclin_C-dom

CCNE1 CCNE2

2.03e-0317742IPR004367
DomainCyclin_C

CCNE1 CCNE2

2.03e-0317742SM01332
DomainPI3/4_kinase_cat_dom

PI4KA ATM

2.27e-0318742IPR000403
DomainPI3_PI4_kinase

PI4KA ATM

2.27e-0318742PF00454
DomainPI3_4_KINASE_3

PI4KA ATM

2.27e-0318742PS50290
DomainPI3_4_KINASE_1

PI4KA ATM

2.27e-0318742PS00915
DomainPI3_4_KINASE_2

PI4KA ATM

2.27e-0318742PS00916
DomainUDPGT

UGT2B4 UGT2B7

3.10e-0321742PF00201
DomainUDPGT

UGT2B4 UGT2B7

3.10e-0321742PS00375
DomainUDP_glucos_trans

UGT2B4 UGT2B7

3.10e-0321742IPR002213
DomainCYCLINS

CCNE1 CCNE2

5.48e-0328742PS00292
DomainThioredoxin

TUSC3 TXNDC11

6.69e-0331742PF00085
DomainCyclin_N

CCNE1 CCNE2

7.55e-0333742IPR006671
DomainCyclin_N

CCNE1 CCNE2

7.55e-0333742PF00134
DomainRGS

RGS14 RGSL1

8.47e-0335742PF00615
DomainRGS

RGS14 RGSL1

8.94e-0336742PS50132
PathwayWP_P53_SIGNALING

CCNE1 THBS1 CCNE2 ATM

1.26e-0465564MM15852
PathwayKEGG_P53_SIGNALING_PATHWAY

CCNE1 THBS1 CCNE2 ATM

1.51e-0468564M6370
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_ER_MEMBRANE

SBF1 PI4KA

1.54e-045562MM14588
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_ER_MEMBRANE

SBF1 PI4KA

1.54e-045562M26963
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH5 DNAH8 DNAH11

1.62e-0427563M47755
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E7_TO_P27_CELL_CYCLE_G1_S

CCNE1 CCNE2

3.21e-047562M47527
PathwayKEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_P21_CELL_CYCLE_G1_S_N00498

CCNE1 CCNE2

4.27e-048562M47585
PathwayKEGG_MEDICUS_VARIANT_LOSS_OF_CDKN1B_TO_P27_CELL_CYCLE_G1_S

CCNE1 CCNE2

4.27e-048562M47429
PathwayREACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS

CCNE1 CCNE2 FBXL3

4.90e-0439563M3871
PathwayKEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_P21_CELL_CYCLE_G1_S_N00497

CCNE1 CCNE2

5.48e-049562M47584
PathwayKEGG_MEDICUS_PATHOGEN_EBV_EBNA3C_TO_P27_CELL_CYCLE_G1_S_N00482

CCNE1 CCNE2

5.48e-049562M47578
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_G1_CELL_CYCLE_ARREST

CCNE1 CCNE2

5.48e-049562MM15337
PathwayKEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM

UGT2B4 UGT2B7 ALAS2

5.69e-0441563M7399
PathwayKEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT

DNAH5 DNAH8 DNAH11

6.55e-0443563M47669
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH5 DNAH8 DNAH11

7.49e-0445563M47670
PathwayKEGG_MEDICUS_PATHOGEN_EBV_EBNA3C_TO_P27_CELL_CYCLE_G1_S_N00264

CCNE1 CCNE2

8.33e-0411562M47492
PathwayKEGG_MEDICUS_REFERENCE_MDM2_P21_CELL_CYCLE_G1_S_N00536

CCNE1 CCNE2

8.33e-0411562M47591
PathwaySA_REG_CASCADE_OF_CYCLIN_EXPR

CCNE1 CCNE2

1.18e-0313562M3686
PathwayREACTOME_DNA_DAMAGE_TELOMERE_STRESS_INDUCED_SENESCENCE

CCNE1 CCNE2 ATM

1.28e-0354563MM14904
PathwayWP_CODEINE_AND_MORPHINE_METABOLISM

UGT2B4 UGT2B7

1.37e-0314562M39328
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_G1_CELL_CYCLE_ARREST

CCNE1 CCNE2

1.37e-0314562M27635
PathwayKEGG_MEDICUS_REFERENCE_P27_CELL_CYCLE_G1_S

CCNE1 CCNE2

1.37e-0314562M47427
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

DENND5B FLG THBS1 SLC9A8 RGSL1 MIA2 GLG1 TBC1D12 EEF1AKMT1 MMP1 TMEM87A DENND4C ADGRL4

2.52e-09686751329987050
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH5 DNAH8 DNAH11

3.35e-0777539256245
Pubmed

Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

DNAH5 DNAH8 DNAH11

3.35e-07775331178125
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH5 DNAH8 DNAH11

3.45e-06147539373155
Pubmed

Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate.

UGT2B4 UGT2B7

4.59e-06275210222050
Pubmed

Which cyclin E prevails as prognostic marker for breast cancer? Results from a retrospective study involving 635 lymph node-negative breast cancer patients.

CCNE1 CCNE2

4.59e-06275216740753
Pubmed

IL-18 enhances thrombospondin-1 production in human gastric cancer via JNK pathway.

THBS1 IL18

4.59e-06275216650813
Pubmed

Expression of cyclins E1 and E2 during mouse development and in neoplasia.

CCNE1 CCNE2

4.59e-06275211687642
Pubmed

Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells.

CCNE1 CCNE2

4.59e-06275221109536
Pubmed

Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33.

UGT2B4 UGT2B7

4.59e-06275217263731
Pubmed

Aberrant cell cycle progression and endoreplication in regenerating livers of mice that lack a single E-type cyclin.

CCNE1 CCNE2

4.59e-06275219445941
Pubmed

Rare variants in dynein heavy chain genes in two individuals with situs inversus and developmental dyslexia: a case report.

DNAH5 DNAH11

4.59e-06275232357925
Pubmed

Kinase-independent function of cyclin E.

CCNE1 CCNE2

4.59e-06275217218276
Pubmed

Interleukin-18 may lead to benign prostatic hyperplasia via thrombospondin-1 production in prostatic smooth muscle cells.

THBS1 IL18

4.59e-06275224615654
Pubmed

Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population.

UGT2B4 UGT2B7

4.59e-06275215319348
Pubmed

Ciliary defects and genetics of primary ciliary dyskinesia.

DNAH5 DNAH11

4.59e-06275219410201
Pubmed

E-type cyclins modulate telomere integrity in mammalian male meiosis.

CCNE1 CCNE2

4.59e-06275226712234
Pubmed

Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells.

CCNE1 CCNE2

4.59e-06275212970191
Pubmed

Cyclin E2 induces genomic instability by mechanisms distinct from cyclin E1.

CCNE1 CCNE2

4.59e-06275223324395
Pubmed

Regulation of cyclin E protein levels through E2F-mediated inhibition of degradation.

CCNE1 CCNE2

4.59e-06275215611651
Pubmed

Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.

RGS14 CARS1 CASR

7.68e-061875324068962
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

SLC9A8 PSD3 WDR35 PCNX1 CACNA1G CLEC16A

9.52e-0622575612168954
Pubmed

Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor.

PI4KA CASR

1.37e-05375211907035
Pubmed

Motor Neuron and Pancreas Homeobox 1 (MNX1) Is Involved in Promoting Squamous Cervical Cancer Proliferation via Regulating Cyclin E.

CCNE1 CCNE2

1.37e-05375231436258
Pubmed

Prostate Cancer-Associated Kallikrein-Related Peptidase 4 Activates Matrix Metalloproteinase-1 and Thrombospondin-1.

THBS1 MMP1

1.37e-05375227378148
Pubmed

Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice.

CCNE1 CCNE2

1.37e-05375223787781
Pubmed

Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13.

UGT2B4 UGT2B7

1.37e-0537527835904
Pubmed

Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions .

UGT2B4 UGT2B7

1.37e-05375229138287
Pubmed

Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis.

CCNE1 CCNE2

1.37e-05375224586195
Pubmed

Tumour-suppressive microRNA-144-5p directly targets CCNE1/2 as potential prognostic markers in bladder cancer.

CCNE1 CCNE2

1.37e-05375226057453
Pubmed

Role of E2F1-cyclin E1-cyclin E2 circuit in human coronary smooth muscle cell proliferation and therapeutic potential of its downregulation by siRNAs.

CCNE1 CCNE2

1.37e-05375219603101
Pubmed

Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo.

CCNE1 CCNE2

1.37e-05375227828963
Pubmed

Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis.

CCNE1 CCNE2

1.37e-05375221746877
Pubmed

Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects.

UGT2B4 UGT2B7

1.37e-05375222092298
Pubmed

Kinase-independent function of E-type cyclins in liver cancer.

CCNE1 CCNE2

1.37e-05375229339491
Pubmed

Expression of members of the putative olfactory receptor gene family in mammalian germ cells.

OR7A5 OR1J4 OR1J2

2.14e-05257531370859
Pubmed

Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival.

TUSC3 PSD3

2.75e-05475216270321
Pubmed

Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases.

CCNE1 CCNE2

2.75e-05475210454565
Pubmed

Loss of Cyclin E1 attenuates hepatitis and hepatocarcinogenesis in a mouse model of chronic liver injury.

CCNE1 CCNE2

2.75e-05475229551768
Pubmed

Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.

RGS14 GNAI3

2.75e-05475217635935
Pubmed

Contribution of polymorphisms in UDP-glucuronosyltransferase and CYP2D6 to the individual variation in disposition of carvedilol.

UGT2B4 UGT2B7

2.75e-05475216849011
Pubmed

Peptide-mediated disruption of calmodulin-cyclin E interactions inhibits proliferation of vascular smooth muscle cells and neointima formation.

CCNE1 CCNE2

2.75e-05475221372285
Pubmed

Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma.

CCNE1 CCNE2

2.75e-05475230150405
Pubmed

Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia.

DNAH5 DNAH11

2.75e-05475218492703
Pubmed

Cyclin-dependent kinase control of motile ciliogenesis.

CCNE1 CCNE2

2.75e-05475230152757
Pubmed

Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2.

IL18 ATM

2.75e-0547529022080
Pubmed

Primary Ciliary Dyskinesia

DNAH5 DNAH8 DNAH11

4.57e-053275320301301
Pubmed

High prevalence of respiratory ciliary dysfunction in congenital heart disease patients with heterotaxy.

DNAH5 DNAH11

4.57e-05575222499950
Pubmed

DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes.

DNAH5 DNAH11

4.57e-05575226909801
Pubmed

UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients.

UGT2B4 UGT2B7

4.57e-05575215318931
Pubmed

Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes.

CCNE1 CCNE2

4.57e-05575216954383
Pubmed

Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm.

CCNE1 CCNE2

4.57e-05575211907280
Pubmed

RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity.

RGS14 GNAI3

4.57e-05575211387333
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

DPYSL2 THBS1 MIA2 ANO6 GLG1 HS6ST2 GNAI3 ATM TMEM41B TMEM87A TXNDC11

5.15e-051201751135696571
Pubmed

Knockdown of either filaggrin or loricrin increases the productions of interleukin (IL)-1α, IL-8, IL-18 and granulocyte macrophage colony-stimulating factor in stratified human keratinocytes.

FLG IL18

6.84e-05675226381575
Pubmed

A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection.

IL18 NCF2

6.84e-05675234047696
Pubmed

Cyclin E ablation in the mouse.

CCNE1 CCNE2

6.84e-05675212941272
Pubmed

CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.

DNAH5 DNAH11

6.84e-05675233347437
Pubmed

Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle.

CCNE1 CCNE2

6.84e-0567529840927
Pubmed

CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade.

CCNE1 CCNE2

6.84e-05675223479742
Pubmed

G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells.

CCNE1 CCNE2

6.84e-05675228192421
Pubmed

Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.

DENND5B SBF1 DENND4C

7.10e-053775320937701
Pubmed

Activation state-dependent interaction between Galphai and p67phox.

NCF2 GNAI3

9.57e-05775216782902
Pubmed

Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.

UGT2B4 UGT2B7

9.57e-05775226074487
Pubmed

Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.

CCNE1 CCNE2

9.57e-05775219592082
Pubmed

Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice.

CCNE1 CCNE2

1.27e-04875215124020
Pubmed

Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.

UGT2B4 UGT2B7

1.27e-04875232093886
Pubmed

Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms.

UGT2B4 UGT2B7

1.27e-04875218052087
Pubmed

Association of interleukin-10 promoter single nucleotide polymorphisms -819 T/C and -592 A/C with aging.

IL18 MMP1

1.27e-04875216424284
Pubmed

Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine.

UGT2B4 UGT2B7

1.27e-04875210748067
Pubmed

Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.

CCNE1 FBXL3

1.27e-04875223453757
Pubmed

The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.

UGT2B4 UGT2B7

1.27e-04875218719240
Pubmed

Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States.

UGT2B4 UGT2B7

1.27e-04875220142249
Pubmed

Multiple mouse chromosomal loci for dynein-based motility.

DNAH5 DNAH8 DNAH14

1.46e-04477538812413
Pubmed

Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2.

CCNE1 CCNE2

1.64e-0497527799941
Pubmed

Cell cycle regulation in mouse heart during embryonic and postnatal stages.

CCNE1 CCNE2

1.64e-04975222957921
Pubmed

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

CCNE1 CCNE2

1.64e-04975211463388
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

CCNE1 CCNE2 ENTPD1 CARS1 MMP1 KMT2E DNAH5 DNAH11

1.77e-0473075834857952
Pubmed

Uterine Epithelial Estrogen Receptor-α Controls Decidualization via a Paracrine Mechanism.

CCNE1 CCNE2

2.04e-041075226241389
Pubmed

Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.

CCNE1 CCNE2

2.04e-041075217254966
Pubmed

Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.

CCNE1 CCNE2

2.04e-041075224358021
Pubmed

A calmodulin-binding site on cyclin E mediates Ca2+-sensitive G1/s transitions in vascular smooth muscle cells.

CCNE1 CCNE2

2.04e-041075216627785
Pubmed

Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase.

CCNE1 CCNE2

2.04e-04107527629134
Pubmed

Expression of cyclin E in postmitotic neurons during development and in the adult mouse brain.

CCNE1 CCNE2

2.04e-041075220863901
Pubmed

MDC1 is a mediator of the mammalian DNA damage checkpoint.

CCNE1 ATM

2.49e-041175212607005
Pubmed

Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration.

CCNE1 CCNE2

2.49e-041175229453456
Pubmed

Control of Metastases via Myeloid CD39 and NK Cell Effector Function.

IL18 ENTPD1

2.49e-041175231992567
Pubmed

A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue- or cell type-specific manner.

CCNE1 CCNE2

2.49e-041175217475776
Pubmed

E2F4 cooperates with pRB in the development of extra-embryonic tissues.

CCNE1 CCNE2

2.99e-041275219433082
Pubmed

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.

UGT2B4 UGT2B7

2.99e-041275220308471
Pubmed

Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins.

CCNE1 CCNE2

2.99e-04127529840943
Pubmed

Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis.

UGT2B4 UGT2B7

2.99e-041275218161889
Pubmed

RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao.

RGS14 GNAI3

2.99e-041275210926822
Pubmed

Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons.

CCNE1 CCNE2 ATM

3.17e-046175334746147
Pubmed

Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.

THBS1 CCNE2 ATM

3.17e-046175327694478
Pubmed

The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.

DNAH5 DNAH11

3.52e-041375217884984
Pubmed

Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation.

CCNE1 CCNE2

3.52e-041375221944720
Pubmed

Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6.

CCNE1 CCNE2

3.52e-04137527739547
Pubmed

Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice.

CCNE1 CCNE2

4.11e-041475211850820
Pubmed

RPLP1, a crucial ribosomal protein for embryonic development of the nervous system.

CCNE1 CCNE2

4.11e-041475224959908
InteractionCSK interactions

DENND5B FLG THBS1 SLC9A8 RGSL1 MIA2 GLG1 TBC1D12 EEF1AKMT1 MMP1 TMEM87A DENND4C ADGRL4

9.89e-068617213int:CSK
Cytoband4q13

UGT2B4 UGT2B7

2.73e-04157524q13
Cytoband16p13.13

CLEC16A TXNDC11

4.91e-042075216p13.13
Cytoband1q25

RGSL1 NCF2

8.34e-04267521q25
GeneFamilyDyneins, axonemal

DNAH5 DNAH8 DNAH14 DNAH11

1.01e-0717484536
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

DENND5B SBF1 DENND4C

3.88e-0525483504
GeneFamilyCyclins

CCNE1 CCNE2

2.50e-0328482473
GeneFamilyUDP glucuronosyltransferases

UGT2B4 UGT2B7

3.25e-0332482363
GeneFamilyOlfactory receptors, family 1

OR1J4 OR1J2

5.05e-0340482147
GeneFamilyC-type lectin domain family

MRC1 CLEC16A

6.91e-0347482494
CoexpressionGSE19198_1H_VS_6H_IL21_TREATED_TCELL_DN

THBS1 IL18 SUPV3L1 AOAH CARS1 ATP11A ATM

1.74e-06200757M7232
CoexpressionDELYS_THYROID_CANCER_UP

MRC1 THBS1 TUSC3 ENTPD1 PSD3 NCF2 ATP11A MMP1 TMEM87A

5.04e-06445759M3645
CoexpressionGSE21678_WT_VS_FOXO1_FOXO3_KO_TREG_UP

THBS1 SLC9A8 C6orf62 SUPV3L1 KMT2E TXNDC11

1.95e-05193756M7395
CoexpressionFULLER_PBMC_F_TULARENSIS_VACCINE_LVS_AGE_22_54YO_18HR_TO_48HR_EARLY_UP

IL18 ENTPD1 NCF2

2.11e-0519753M40968
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_dendritic-CD1c-positive_myeloid_dendritic_cell|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MRC1 DPYSL2 THBS1 IL18 MCTP1 AOAH NCF2

3.22e-08189757e4b2f00cb3675a4d94e8807d6ff99cc55f9ed233
ToppCellRA-08._Macrophage|World / Chamber and Cluster_Paper

MRC1 THBS1 MCTP1 AOAH ENTPD1 KCNMA1 PCNX1

3.72e-081937575fd22db1825d105709fcc0aa4955c99a117e3c82
ToppCellRA-08._Macrophage|RA / Chamber and Cluster_Paper

MRC1 THBS1 MCTP1 AOAH ENTPD1 KCNMA1 PCNX1

3.85e-08194757ac26e5c71d5069622de72fa25a9c920887ac2c19
ToppCell10x5'-bone_marrow-Myeloid_Dendritic-DC2|bone_marrow / Manually curated celltypes from each tissue

MRC1 DPYSL2 IL18 MCTP1 ENTPD1 NCF2

4.63e-0717275664928cea7e5b60e4bc4af016454b0173ebcc07c7
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 AOAH KCNMA1 NCF2 CACNA1G

5.66e-0717875624e8c62060455159235985f456af0c5023a7f3f5
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 AOAH KCNMA1 NCF2 CACNA1G

5.66e-071787564f1cc954d4d9b5b2b75a4cf995ba81e2ada27084
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 AOAH ENTPD1 KCNMA1 NCF2

6.65e-07183756a97f052950429245c3231464271e1ba539863bba
ToppCellControl-Myeloid-Transitioning_MDM|Control / group, cell type (main and fine annotations)

MRC1 THBS1 MCTP1 AOAH ENTPD1 KCNMA1

8.28e-07190756d6fd8c23cde4a10cc1517b6899a5a855fdfff2e2
ToppCellLA-08._Macrophage|World / Chamber and Cluster_Paper

MRC1 THBS1 MCTP1 AOAH ENTPD1 KCNMA1

9.35e-07194756c1805572bcc11b1cd29083329d7b5911489fb758
ToppCellLA-08._Macrophage|LA / Chamber and Cluster_Paper

MRC1 THBS1 MCTP1 AOAH ENTPD1 KCNMA1

9.64e-071957565e1d5bdb8874091f5a2b1d0a8cc9008165718a97
ToppCellILEUM-inflamed-(3)_Resident_macrophages|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MRC1 THBS1 IL18 AOAH KCNMA1 NCF2

9.93e-071967565ac246a823a8e1996325753858615269687b429d
ToppCelldroplet-Fat-Mat-18m-Myeloid-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 SERPINA11 MCTP1 AOAH CASR

7.77e-061617558c62ae3fcf304db0f71633e328ceba81a70f03c4
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MRC1 IL18 CCNE2 AOAH SERINC3

1.04e-05171755bf475a69db04d4a886e442704955c6a96ff0de46
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MRC1 IL18 AOAH SERINC3 NCF2

1.07e-05172755714172f31abd0d25261df6115ec6a9df491fa14b
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MRC1 IL18 AOAH SERINC3 NCF2

1.13e-051747550a8fa44604be19fbac722ebc6d1cd72b71be7022
ToppCell3'_v3|World / Manually curated celltypes from each tissue

MRC1 DPYSL2 THBS1 C6orf62 NCF2

1.26e-0517875542502f14d9c756df8104900ac6484477b885d3d9
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-LYVE1+_Macrophage|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 THBS1 AOAH KCNMA1 NCF2

1.33e-0518075566c7b02d85e32ba3e7530d0c4aff17e7525ccdd8
ToppCellControl-Myeloid-Dendritic_cells|Control / group, cell type (main and fine annotations)

MRC1 MCTP1 AOAH ENTPD1 KCNMA1

1.33e-0518075525ad95c3c30e3b82abe93bd77ba003f5c2241f7c
ToppCellCOVID-19-Heart-EC_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

MCTP1 SV2B ENTPD1 AGMO ADGRL4

1.44e-05183755ff95382cfed592190d0636d2b750328471f82e0d
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC1 THBS1 NCF2 SLC35E3 DENND4C

1.48e-05184755840fac463665ed18752f402f7d1ef2e5052bdf74
ToppCell3'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPYSL2 MCTP1 ENTPD1 UNC93A ADGRL4

1.52e-05185755fa94c4a1660967f211ba095606cd0aa37d38e17a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PSD3 KCNMA1 UGT2B7 CASR DNAH5

1.60e-0518775587b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell3'-Adult-Appendix-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPYSL2 MCTP1 ENTPD1 UNC93A ADGRL4

1.60e-0518775537d8ee5c8bd6324749e5a2adef1d0482c75da80c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PSD3 KCNMA1 UGT2B7 CASR DNAH5

1.60e-0518775542a1267bfc27b4460b8409ada580a87c4385841c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PSD3 KCNMA1 UGT2B7 CASR DNAH5

1.60e-0518775564afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell3'-Adult-Appendix-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPYSL2 MCTP1 ENTPD1 UNC93A ADGRL4

1.60e-05187755ec98d5e480b08854dfd0ba6b1dc6610455f90640
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)|Children_(3_yrs) / Lineage, Cell type, age group and donor

MRC1 AOAH ENTPD1 PSD3 KCNMA1

1.73e-05190755f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

UGT2B7 CASR ATP11A DNAH5 DNAH14

1.73e-051907553fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCellLV-08._Macrophage|World / Chamber and Cluster_Paper

MRC1 THBS1 MCTP1 AOAH KCNMA1

1.77e-05191755e7a0bc46ba9ba772636a583f3387748418e18832
ToppCellhuman_hepatoblastoma-Inflammatory_Monocytes|World / Sample and Cell Type and Tumor Cluster (all cells)

IL18 MCTP1 AOAH ENTPD1 KCNMA1

1.77e-051917553b59bfc6c106ae8a3fbcd4a74bd128c485724921
ToppCellControl-Myeloid|Control / group, cell type (main and fine annotations)

MRC1 MCTP1 AOAH KCNMA1 NCF2

1.77e-051917559c4acc5f3c2f9c0c5520863bb22f391774372347
ToppCellLV-08._Macrophage|LV / Chamber and Cluster_Paper

MRC1 THBS1 MCTP1 AOAH KCNMA1

1.82e-051927557be12d580aaf2f2f1562203fcad3a44639b8c5a6
ToppCell5'-GW_trimst-1.5-LargeIntestine-Hematopoietic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 SERPINA11 MCTP1 NCF2 ALAS2

1.82e-05192755453c11f468117ffdd8c248fee1e5bb1f5401cc33
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MRC1 DPYSL2 IL18 TBC1D12 NCF2

1.87e-051937556b3a2a32ec6dc96230cee4bbf03932f8a81e6683
ToppCellRV-08._Macrophage|RV / Chamber and Cluster_Paper

MRC1 THBS1 MCTP1 AOAH KCNMA1

1.87e-0519375512bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MRC1 DPYSL2 IL18 TBC1D12 NCF2

1.87e-05193755b18c61e360f5f094f260007a56b189e2a48369e4
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 IL18 AOAH KCNMA1 NCF2

1.87e-05193755bd08555f02db8bc903caacae57e80bb91e2556ce
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 IL18 AOAH KCNMA1 NCF2

1.87e-05193755374d0526a071e973c3f43b4564f78f6933bb67ed
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-C|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MRC1 THBS1 IL18 C6orf62 AOAH

1.87e-0519375579a95ac4f46abee00e03700c10cdb00c4507ea76
ToppCellCOPD-Myeloid-Macrophage|World / Disease state, Lineage and Cell class

MRC1 THBS1 MCTP1 KCNMA1 PCNX1

1.91e-051947557d682408e9a6239a4e47befc9376e760cc3d133a
ToppCellwk_20-22-Hematologic-Myeloid-DC2|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

IL18 MCTP1 AOAH ENTPD1 NCF2

1.91e-051947556a9bb5ad04aba13a4886fa27a96e28e90b6586e3
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 AOAH KCNMA1 NCF2

1.91e-05194755c95d5c4ad0210ebd672926558cc8331e6396a854
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 PSD3 KCNMA1 DENND4C

1.91e-0519475545708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PSD3 CASR ATP11A DNAH5 CLEC16A

1.96e-05195755938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell(7)_DC_2|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

MRC1 IL18 MCTP1 AOAH NCF2

1.96e-0519575563abdf512368a32e586f8dc87090796f19a146c6
ToppCellCOVID-19-Myeloid-Monocyte-derived_macrophages|COVID-19 / group, cell type (main and fine annotations)

MRC1 MCTP1 AOAH KCNMA1 NCF2

1.96e-05195755c172c5599379c29123340621a36bfb1fc90c2115
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|lung / Disease (COVID-19 only), tissue and cell type

MRC1 MCTP1 AOAH KCNMA1 NCF2

1.96e-05195755148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 AOAH ENTPD1 NCF2

1.96e-0519575562dc745e1aa3e2e58afa16c7bb2cf9b03d4e8105
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 ENTPD1 KCNMA1 DENND4C

1.96e-05195755247803cf58c6d9c561a52aa34e581188ddad197e
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_monocytic-intermediate_monocyte|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MRC1 DPYSL2 THBS1 MCTP1 NCF2

1.96e-05195755403d874198a7bde626b0d0b4efad8dbb34060761
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 AOAH KCNMA1 NCF2

1.96e-0519575542bfdff88da1d07828c0ad65d412fb1752f0cee4
ToppCellBAL-Control|BAL / Compartment, Disease Groups and Clusters

MRC1 DPYSL2 IL18 ENTPD1 TMBIM4

1.96e-05195755bf940d836a34118a56bc956e6210e310510bca4d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PSD3 CASR ATP11A DNAH5 CLEC16A

1.96e-05195755d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 AOAH ENTPD1 KCNMA1 NCF2

1.96e-0519575509df40ff9b493170861b3f6e57a942a834655b5c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 AOAH ENTPD1 KCNMA1

1.96e-0519575534a9462f4e843f3065cc58c17ad71c1b5b836ae1
ToppCell10x5'-lymph-node_spleen-Myeloid_Dendritic-DC2|lymph-node_spleen / Manually curated celltypes from each tissue

MRC1 DPYSL2 IL18 MCTP1 NCF2

2.01e-051967559666b5380e2b2a3c3b56a8c769817a1df8820ed6
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_monocytic|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MRC1 DPYSL2 THBS1 MCTP1 NCF2

2.01e-05196755f943519bff51c3094776fd45889dadf9062c8379
ToppCellILEUM-inflamed-(3)_DC2|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MRC1 THBS1 IL18 AOAH NCF2

2.01e-051967550a7f77ed4ea3afdd9ad8a2d2c5df83778be5197b
ToppCellILEUM-non-inflamed-(3)_Resident_macrophages|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MRC1 THBS1 IL18 AOAH NCF2

2.06e-051977553af24354b6a93c7d105b9fa6549cf215107b9203
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 AOAH ENTPD1 NCF2

2.06e-051977558af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 AOAH KCNMA1 NCF2

2.06e-051977556ca6e17b7cc5f7ea8d4b6ca1ff670969bee65a45
ToppCellCOVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

MRC1 MCTP1 AOAH KCNMA1 NCF2

2.06e-05197755e42910a653a1b5bd90c090e9665a84871ed2873f
ToppCellILEUM-inflamed-(3)_MNP|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MRC1 THBS1 IL18 AOAH NCF2

2.06e-05197755b105bad5ac85961919a654a38587d1017973c981
ToppCellCOVID-19-kidney-Macrophages|COVID-19 / Disease (COVID-19 only), tissue and cell type

MRC1 IL18 MCTP1 AOAH KCNMA1

2.06e-051977553912301018d0863144dcfac8d1fa8adc081748d7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 AOAH ENTPD1 NCF2

2.06e-05197755c9b1f2ee7eb31a66af331c5aae29e1bbb5186f5a
ToppCellCOVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi|lung / Disease (COVID-19 only), tissue and cell type

MRC1 MCTP1 AOAH KCNMA1 NCF2

2.06e-051977553896729740d151f0eb845f1961c7b969bfbdd28d
ToppCellILEUM-non-inflamed-(3)_MNP|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MRC1 THBS1 IL18 AOAH NCF2

2.06e-0519775564fdc12e7ffade669cc1de081b10e84a27f0d1b5
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 AOAH ENTPD1 NCF2

2.06e-0519775557dafb3047745a44b2345b8036e159c3641d496e
ToppCellbackground-Kupffer_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

MRC1 IL18 MCTP1 AOAH KCNMA1

2.06e-051977558b45c7ecc18d188abc8c172d9bf881c95617a46a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 AOAH ENTPD1 NCF2

2.06e-051977551eb9ff8467118b943b5d443cb996168e1e1206b5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 AOAH ENTPD1 NCF2

2.06e-0519775572cd61b868d57862ec9c230ea68913d3829b0f2b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 AOAH ENTPD1 NCF2

2.11e-0519875596883ad8e189a46ed5b7eaafc0543e53682d26ed
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MRC1 DPYSL2 IL18 MCTP1 NCF2

2.11e-05198755898ef4f02443780f9b1fc08b73a165fda0ca5cde
ToppCellFetal_29-31_weeks-Immune|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MRC1 MCTP1 AOAH ENTPD1 NCF2

2.11e-051987555dff131356b8c22743bd27b2b21f86ee6e4a0a0d
ToppCellILEUM-inflamed-(3)_MNP-(3)_Resident_macrophages|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MRC1 THBS1 IL18 AOAH KCNMA1

2.11e-0519875530bf78d4d657cf5140549d3dbf43d4f00482e300
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-conventional_dendritic_cell|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MRC1 DPYSL2 IL18 MCTP1 NCF2

2.11e-0519875542be18aef4f656a86c61630b061826a858c496fd
ToppCellMultiple_Sclerosis-Myeloid-cDC|Multiple_Sclerosis / Disease, Lineage and Cell Type

MRC1 DPYSL2 IL18 AOAH NCF2

2.11e-05198755ac139bfbf52b2feddb0c05b0708c8c9efbe119c9
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 ENTPD1 PSD3 KCNMA1 NCF2

2.11e-05198755c7dbf24caae5c4ef285845d13055de9e07281bb3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 AOAH ENTPD1 NCF2

2.11e-05198755623f9d64c9e800d2d7f623392bf2f22b563f0249
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MCTP1 AOAH ENTPD1 NCF2

2.16e-0519975504adf46975aa4194ea40c7480f8a517def5d929c
ToppCell3'_v3-Lung-Myeloid_Mac|Lung / Manually curated celltypes from each tissue

MRC1 DPYSL2 KCNMA1 NCF2 DENND4C

2.16e-051997551677aaee5b7f5f262e27df5d9f1bdf6e21e3d804
ToppCellFetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MRC1 MCTP1 ENTPD1 KCNMA1 NCF2

2.16e-0519975522001aa733273e784051b7f750e07d99aaf7a225
ToppCellwk_20-22-Hematologic|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

MRC1 MCTP1 AOAH NCF2 ALAS2

2.16e-05199755f360c75e169536578550bed79461a5947e2472b1
ToppCell3'_v3-Lung-Myeloid_Mac-Alveolar_macrophages|Lung / Manually curated celltypes from each tissue

MRC1 DPYSL2 KCNMA1 NCF2 DENND4C

2.16e-05199755eec1b086e5e8b9b0e1770dd269ca903f713d99a8
ToppCellParenchymal-NucSeq-Immune_Myeloid|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 AOAH ENTPD1 KCNMA1 NCF2

2.16e-051997557ee2805fd9143eba11bf6832267b62189683608b
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC1 THBS1 NCF2 SLC35E3 DENND4C

2.16e-051997558e9862907b15809d083216e7d6a0f435015e5d15
ToppCellTransverse-(6)_Macrophage|Transverse / shred on region, Cell_type, and subtype

MRC1 DPYSL2 THBS1 KCNMA1 NCF2

2.21e-05200755b28350de555fa756d2631f004f71d5ac69b1affe
ToppCellmild-HLA-DR+_CD83+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MCTP1 AOAH ENTPD1 NCF2 ATP11A

2.21e-05200755934c2efc780318c66d667ca75be0de350361d351
ToppCellmLN-Macrophage|mLN / Region, Cell class and subclass

MRC1 THBS1 IL18 KCNMA1 NCF2

2.21e-0520075568d709afd226241e002dae6d6820bccd1cfd87a1
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 THBS1 IL18 KCNMA1 NCF2

2.21e-05200755c325dc52e4bf3829a35905b956784ca3e9191926
ToppCellTransverse-Macrophage|Transverse / Region, Cell class and subclass

MRC1 DPYSL2 THBS1 KCNMA1 NCF2

2.21e-052007551920605e5811938814d02b971069a4506868db5f
ToppCellBronchial-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD14|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 THBS1 AOAH ENTPD1 NCF2

2.21e-052007555432bdf495431cd26f6e4cd585100f3652588913
ToppCellmLN-(6)_Macrophage|mLN / shred on region, Cell_type, and subtype

MRC1 THBS1 IL18 KCNMA1 NCF2

2.21e-052007556dcba82a7d322102bae205543086e84c7655b3e0
ToppCelltumor_Lung-Endothelial_cells-Tumor_ECs|Endothelial_cells / Location, Cell class and cell subclass

THBS1 MCTP1 ENTPD1 MMP1 ADGRL4

2.21e-052007559c1b30fa96565515a7160f439cadcd51482c41e9
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intermediate|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 AOAH ENTPD1 KCNMA1 NCF2

2.21e-0520075546f9c28b24e39acdf0481a02b6eb86ecdd83c504
ToppCellMS-Multiple_Sclerosis-Myeloid-cDC|Multiple_Sclerosis / Disease, condition lineage and cell class

MRC1 DPYSL2 IL18 AOAH NCF2

2.21e-05200755d9e6c344c59544c87bc13d1e866491da432c9c1b
ToppCell(50)_cDC2|World / shred on Cell_type and subtype

MRC1 DPYSL2 IL18 NCF2 MMP1

2.55e-05206755d519adeb8290fcce107e81a439ba3bf1e231b55b
ToppCellfacs-Skin-nan-18m-Myeloid-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 RGS14 AOAH NCF2

1.17e-0414975423a1b95c12f2e3708dc003e13fab423e89821f11
ToppCellfacs-Skin-nan-18m-Myeloid-macrophage|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 RGS14 AOAH NCF2

1.17e-04149754c53a3226adc8fd0eaaa842b6a96442287580cbe0
ToppCellfacs-Skin-nan-18m-Myeloid|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 RGS14 AOAH NCF2

1.17e-04149754bb18a18b891af85849b9658d774053f839c9a8e1
ComputationalGenes in the cancer module 227.

UGT2B4 UGT2B7 ALAS2

2.44e-0515423MODULE_227
DrugBiliton

UGT2B4 UGT2B7 DNAH5 DNAH8 DNAH11

2.31e-0741755CID000002974
DrugZectran

KCNMA1 SERINC3 ALAS2

6.82e-076753CID000009414
Diseasenephrolithiasis (is_implicated_in)

RGS14 CASR

1.76e-053722DOID:585 (is_implicated_in)
DiseaseKartagener syndrome (is_implicated_in)

DNAH5 DNAH11

3.51e-054722DOID:0050144 (is_implicated_in)
Diseasehuman immunodeficiency virus infectious disease (is_marker_for)

IL18 ATM KMT2E

9.39e-0536723DOID:526 (is_marker_for)
DiseaseHMG CoA reductase inhibitor use measurement

PSD3 UGT2B7 PCNX1 DENND4C DNAH11

1.01e-04189725EFO_0009932
Diseasevitamin D deficiency

UGT2B4 UGT2B7 PCNX1

1.02e-0437723EFO_0003762
DiseaseCiliopathies

WDR35 DNAH5 DNAH8 DNAH11

1.55e-04110724C4277690
Diseasetumor necrosis factor receptor II measurement

RGS14 CCNE2

1.63e-048722EFO_0008384
Diseaseplasma clozapine-to-N-desmethylclozapine ratio measurement

UGT2B4 UGT2B7

2.09e-049722EFO_0600040
Diseaseneuritic plaque measurement

MCTP1 SV2B AGMO UGT2B4 UGT2B7 UNC93A

2.12e-04349726EFO_0006798
DiseaseX-19141 measurement

UGT2B4 UGT2B7

4.50e-0413722EFO_0800799
DiseaseCOVID-19 (is_marker_for)

THBS1 IL18 MMP1

4.98e-0463723DOID:0080600 (is_marker_for)
DiseaseKartagener syndrome (implicated_via_orthology)

DNAH5 DNAH11

5.24e-0414722DOID:0050144 (implicated_via_orthology)
Diseasemyocardial infarction (biomarker_via_orthology)

THBS1 IL18 CASR MMP1

6.43e-04160724DOID:5844 (biomarker_via_orthology)
Diseasemethylcobalamin deficiency type cblE, brain serotonin transporter measurement

AGMO PSD3

6.89e-0416722EFO_0004569, MONDO_0009354
Diseaseurate measurement, bone density

AOAH PSD3 KCNMA1 DNAH8 DNAH14 MPPED1 DNAH11

7.83e-04619727EFO_0003923, EFO_0004531
Diseaseatherosclerosis (biomarker_via_orthology)

IL18 CASR

1.08e-0320722DOID:1936 (biomarker_via_orthology)
Diseasebreast cancer (is_marker_for)

CCNE1 IL18 MMP1 KMT2E

1.10e-03185724DOID:1612 (is_marker_for)
DiseaseBronchiectasis

DNAH5 DNAH11

1.31e-0322722C0006267
DiseaseX-24947 measurement

UGT2B4 UGT2B7

1.31e-0322722EFO_0800910
Diseasevitamin D measurement

FLG UGT2B4 UGT2B7 KMT2E DNAH11

1.39e-03336725EFO_0004631
Diseaseobsolete_red blood cell distribution width

CCNE1 AOAH TBC1D12 LARP1 BCCIP ATP11A ALAS2 DENND4C TXNDC11 ADGRL4

1.55e-0313477210EFO_0005192
Diseaseurinary bladder cancer (is_marker_for)

CCNE1 THBS1 MMP1

2.31e-03107723DOID:11054 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
MLKYFATFEVFFEEN

TBC1D12

631

O60347
TDIALKVFFFDSYNM

ADGRL4

251

Q9HBW9
DAKYSFMESFPFLFN

AKAP14

181

Q86UN6
LADQFDFKMYIAFVF

C6orf62

26

Q9GZU0
VQFALMLAFYEETFA

AGMO

341

Q6ZNB7
FNEAKFITFSMLIFF

CASR

801

P41180
MLIYFNFFKAPFLVD

ABHD12B

71

Q7Z5M8
FYLAQDFFDRYMATQ

CCNE1

166

P24864
ETFYLAQDFFDRFML

CCNE2

161

O96020
NFEKAYFILDEFLMG

AP1S1

106

P61966
ALYVQMSKFEDFRVF

DNAH11

1091

Q96DT5
FTEFLLMVFKLAQAY

FLG

71

P20930
MYFFILFAGFENFLL

OR7A5

101

Q15622
EKFTNFNLFYMDFAF

AOAH

491

P28039
FNLFYMDFAFHEIIQ

AOAH

496

P28039
FFTAPFEKNRMNDFY

ANO6

181

Q4KMQ2
FFLRDHFNKKMYEEF

LARP1

921

Q6PKG0
MYFFIFFTDLDSFLI

OR1J2

101

Q8NGS2
SGFLKFFFYSEIMEL

TMBIM4

166

Q9HC24
IKVFDYDFGLQDDFM

MCTP1

326

Q6DN14
KDFTLQIDMAFNVFF

KCNMA1

211

Q12791
FKLFACEVLYNIAFM

NCF2

116

P19878
ETHFTFKDLYFKMFD

GNAI3

186

P08754
VNSFLVYMAFKDRFQ

DPYSL2

161

Q16555
LMFANAEEEFFYEKA

BCCIP

246

Q9P287
FFKFDYEAFSETMLL

PCNX1

1421

Q96RV3
FEVSEMYIFGKFEAF

DNAH8

351

Q96JB1
KTFYFLFAMFFILVQ

DEFB105A

6

Q8NG35
NFSIYIFEYDKRFAM

EEF1AKMT1

96

Q8WVE0
DRFQVMFCYFEDKAI

PI4KA

911

P42356
KFMLREQFEANGYFF

KMT2E

361

Q8IZD2
DFGAFSAFYFVMKFL

ENTPD1

356

P49961
QEFMADLIKQDFYYF

MPPED1

156

O15442
YVFSYDQFFRDKIME

ALAS2

141

P22557
FKAFAMIAYKFEEDI

PCBP3

101

P57721
LQFPMEFEFSQFYLK

SBF1

1496

O95248
MYFFIFFTDLDNFLL

OR1J4

101

Q8NGS1
FFVQARMEIADFYEK

KICS2

131

Q96MD2
FQLVQMKDFRFSYKF

GLG1

741

Q92896
NFQPVFRYFCMEKFL

ATM

2826

Q13315
LFEEYFLQDKMFITG

GSTT4

146

A0A1W2PR19
DDFIFAFFAVEMVVK

CACNA1G

121

O43497
KVNLVMYFFLYEEEF

FBXL3

286

Q9UKT7
FANRFTQMFADYEAF

DENND5B

506

Q6ZUT9
FFEAFRKFLMFIYKL

DENND4C

321

Q5VZ89
ETFFKFVMLVDYIFQ

DNAH14

421

Q0VDD8
NFLDMELYSYAKDLF

HS6ST2

481

Q96MM7
INFVAMKFIDNTLYF

IL18

11

Q14116
QFDFSEMYIFGKFET

DNAH5

461

Q8TE73
YLFQIDVYDFMNSAF

MIA2

606

Q96PC5
FYSNKCFKIFGFMEE

MRC1

951

P22897
NFAINDLYFFSEMEK

RGSL1

876

A5PLK6
LKDYFKFDVFYCMNI

CARS1

81

P49589
RMYFKHVLFEDTFFD

SV2B

461

Q7L1I2
VDAVFMKDGFFYFFH

MMP1

426

P03956
TFLQALDYFLKMFFG

SLC9A8

256

Q9Y2E8
YFVCNMDDFKFSAEL

SUPV3L1

546

Q8IYB8
FFLEKNMFVFFLNIL

CLEC16A

71

Q2KHT3
EMADFYKEFLSKNFQ

COA8

151

Q96IL0
FTDFLAFMVLFNYII

ATP11A

346

P98196
AFCNKLFFSMVDYDE

TUSC3

121

Q13454
FVFSQEMVFFSDLKY

THBS1

1151

P07996
YVLYFEFWFQIFDMK

UGT2B4

216

P06133
QDTFMVLANYIFFKA

SERPINA11

201

Q86U17
ASMFFNKVGVNLFYF

TMEM104

136

Q8NE00
KDMVNQYFGIFFLIF

UNC93A

131

Q86WB7
SDFKDFIFDDMYIVQ

TTLL2

226

Q9BWV7
QIFNLMKFDSYARFV

RGS14

161

O43566
KAVYRISFAMAIFFF

SERINC3

96

Q13530
SFFEMAAALDSFYLK

TXNDC11

491

Q6PKC3
FLSAAFVMFLVYKNF

TMEM41B

61

Q5BJD5
YVLYFDFWFEIFDMK

UGT2B7

216

P16662
NYFFDAAKLMFKIAD

WDR35

941

Q9P2L0
LVAEEYLKFFDFTGM

PSD3

616

Q9NYI0
YYDVKFNFLGMVFAA

SLC35E3

146

Q7Z769
IFLGMLEKAVFYAEF

TMEM87A

266

Q8NBN3