Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncyclin-dependent protein serine/threonine kinase activity

CDK12 CDK13 CDK11B

2.69e-0430843GO:0004693
GeneOntologyMolecularFunctioncyclin-dependent protein kinase activity

CDK12 CDK13 CDK11B

2.69e-0430843GO:0097472
GeneOntologyMolecularFunctionSUMO transferase activity

EGR2 KIAA1586 TOPORS

4.64e-0436843GO:0019789
GeneOntologyMolecularFunctionRNA polymerase II CTD heptapeptide repeat kinase activity

CDK12 CDK13

7.70e-0410842GO:0008353
GeneOntologyMolecularFunctionprotein serine kinase activity

CDK12 CLK2 CDK13 STK38 CDK11B STK38L WNK2

8.45e-04363847GO:0106310
GeneOntologyMolecularFunctionvoltage-gated chloride channel activity

CLCN3 CLCN4

9.38e-0411842GO:0005247
GeneOntologyBiologicalProcessRNA splicing

TAF6L PPIG CDK12 CLK2 CDK13 SRRM4 LMNTD2 NCBP1 SRSF11 PRPF38B SREK1 THRAP3 RBM39 IWS1

1.43e-085028414GO:0008380
GeneOntologyBiologicalProcessregulation of RNA splicing

TAF6L CDK12 CLK2 SRRM4 LMNTD2 NCBP1 THRAP3 RBM39

2.04e-06207848GO:0043484
GeneOntologyBiologicalProcessmRNA processing

CDK12 CDK13 SRRM4 LMNTD2 NCBP1 SRSF11 PRPF38B SREK1 CDK11B THRAP3 RBM39 IWS1

2.30e-065518412GO:0006397
GeneOntologyBiologicalProcessregulation of mRNA processing

SRRM4 LMNTD2 NCBP1 CDK11B THRAP3 RBM39 IWS1

3.74e-06158847GO:0050684
GeneOntologyBiologicalProcessRNA processing

TAF6L PPIG DCAF13 TSR1 CDK12 CLK2 CDK13 SRRM4 LMNTD2 NCBP1 SRSF11 PRPF38B SREK1 CDK11B LYAR THRAP3 RBM39 RBFA IWS1

7.23e-0615008419GO:0006396
GeneOntologyBiologicalProcessnegative regulation of telomeric DNA binding

ERCC4 TNKS

1.64e-052842GO:1904743
GeneOntologyBiologicalProcessregulation of telomeric DNA binding

ERCC4 TNKS

9.78e-054842GO:1904742
GeneOntologyBiologicalProcesstranscription elongation by RNA polymerase II

RTF1 CDK12 CDK13 NCBP1 IWS1

1.71e-04127845GO:0006368
GeneOntologyBiologicalProcessregulation of mRNA splicing, via spliceosome

SRRM4 LMNTD2 NCBP1 THRAP3 RBM39

1.84e-04129845GO:0048024
GeneOntologyBiologicalProcessalternative mRNA splicing, via spliceosome

CDK13 SRRM4 NCBP1 THRAP3

3.05e-0479844GO:0000380
GeneOntologyBiologicalProcessDNA-templated transcription elongation

RTF1 CDK12 CDK13 NCBP1 IWS1

3.07e-04144845GO:0006354
GeneOntologyBiologicalProcessmRNA metabolic process

CDK12 CDK13 SRRM4 LMNTD2 NCBP1 SRSF11 PRPF38B SREK1 CDK11B THRAP3 RBM39 IWS1

3.28e-049178412GO:0016071
GeneOntologyBiologicalProcessendothelial cell chemotaxis

EGR3 KDR PLEKHG5

3.88e-0435843GO:0035767
GeneOntologyCellularComponentnuclear body

CASP8AP2 BPNT2 PPIG RAD18 CDK12 CLK2 CDK13 SRSF11 TNKS SREK1 TOPORS THRAP3 RBM39 SP140

6.47e-069037914GO:0016604
GeneOntologyCellularComponentnuclear speck

PPIG CDK12 CLK2 CDK13 SRSF11 SREK1 TOPORS THRAP3 RBM39

3.56e-05431799GO:0016607
GeneOntologyCellularComponenttranscription elongation factor complex

RTF1 CDK12 CDK13 MLLT1

5.98e-0556794GO:0008023
GeneOntologyCellularComponenttransferase complex

RTF1 PHF1 TAF6L UBR1 RAD18 DCAF13 TMEM183A CDK12 CDK13 TMEM183BP CDK11B TOPORS

2.53e-049637912GO:1990234
GeneOntologyCellularComponentcyclin/CDK positive transcription elongation factor complex

CDK12 CDK13

4.99e-049792GO:0008024
HumanPhenoRecurrent joint dislocation

BPNT2 PIEZO2 IPO8

1.10e-0514173HP:0031869
DomainTMEM183

TMEM183A TMEM183BP

1.95e-052832IPR026509
DomainDUF3446

EGR2 EGR3

5.84e-053832IPR021849
DomainDUF3446

EGR2 EGR3

5.84e-053832PF11928
DomainNAC

BTF3L4 BTF3

1.93e-045832SM01407
DomainHSR

SP140L SP140

1.93e-045832PS51414
DomainHSR

SP140L SP140

1.93e-045832PF03172
DomainHSR_dom

SP140L SP140

1.93e-045832IPR004865
DomainNAC

BTF3L4 BTF3

2.89e-046832PF01849
DomainNas_poly-pep-assoc_cplx_dom

BTF3L4 BTF3

2.89e-046832IPR002715
DomainNAC_AB

BTF3L4 BTF3

2.89e-046832PS51151
DomainSAND_dom

SP140L SP140

5.37e-048832IPR000770
DomainSAND

SP140L SP140

5.37e-048832PF01342
DomainSAND

SP140L SP140

5.37e-048832PS50864
DomainSAND

SP140L SP140

5.37e-048832SM00258
DomainCl-channel_core

CLCN3 CLCN4

6.88e-049832IPR014743
Domain-

CLCN3 CLCN4

6.88e-0498321.10.3080.10
DomainVoltage_CLC

CLCN3 CLCN4

6.88e-049832PF00654
DomainCl-channel_volt-gated

CLCN3 CLCN4

6.88e-049832IPR001807
DomainPROTEIN_KINASE_ATP

CDK12 CLK2 CDK13 STK38 KDR CDK11B STK38L WNK2

9.86e-04459838PS00107
DomainSer/Thr_kinase_AS

CDK12 CLK2 CDK13 STK38 CDK11B STK38L WNK2

1.05e-03357837IPR008271
DomainS_TKc

CDK12 CLK2 CDK13 STK38 CDK11B STK38L WNK2

1.09e-03359837SM00220
DomainPROTEIN_KINASE_ST

CDK12 CLK2 CDK13 STK38 CDK11B STK38L WNK2

1.14e-03362837PS00108
Domain-

SP140L SP140

1.25e-03128323.10.390.10
DomainSAND_dom-like

SP140L SP140

1.25e-0312832IPR010919
DomainProt_kinase_dom

CDK12 CLK2 CDK13 STK38 KDR CDK11B STK38L WNK2

1.47e-03489838IPR000719
DomainPkinase

CDK12 CLK2 CDK13 STK38 CDK11B STK38L WNK2

1.53e-03381837PF00069
DomainPROTEIN_KINASE_DOM

CDK12 CLK2 CDK13 STK38 KDR CDK11B STK38L WNK2

1.55e-03493838PS50011
DomainCBS

CLCN3 CLCN4

2.25e-0316832SM00116
DomainPoly(ADP-ribose)pol_cat_dom

PARP16 TNKS

2.54e-0317832IPR012317
DomainPARP_CATALYTIC

PARP16 TNKS

2.54e-0317832PS51059
DomainPARP

PARP16 TNKS

2.54e-0317832PF00644
Domain-

PARP16 TNKS

2.54e-03178323.90.228.10
DomainKinase-like_dom

CDK12 CLK2 CDK13 STK38 KDR CDK11B STK38L WNK2

2.80e-03542838IPR011009
DomainZinc_finger_PHD-type_CS

PHF1 SP140L SP140

3.03e-0365833IPR019786
DomainCBS_dom

CLCN3 CLCN4

3.52e-0320832IPR000644
DomainCBS

CLCN3 CLCN4

3.52e-0320832PF00571
DomainCBS

CLCN3 CLCN4

3.52e-0320832PS51371
DomainPHD

PHF1 SP140L SP140

4.54e-0375833PF00628
DomainWGR_domain

PARP16 TNKS

5.05e-0324832IPR008893
DomainZnf_PHD-finger

PHF1 SP140L SP140

5.25e-0379833IPR019787
DomainTUDOR

PHF1 ARID4B

6.37e-0327832SM00333
DomainProtein_kinase_ATP_BS

CDK12 CLK2 CDK13 STK38 KDR STK38L

6.82e-03379836IPR017441
DomainPHD

PHF1 SP140L SP140

7.30e-0389833SM00249
DomainZnf_PHD

PHF1 SP140L SP140

7.76e-0391833IPR001965
DomainTudor

PHF1 ARID4B

7.83e-0330832IPR002999
DomainZF_PHD_2

PHF1 SP140L SP140

8.73e-0395833PS50016
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

RTF1 TAF6L CASP8AP2 PPIG BTF3L4 RAD18 TSR1 CDK12 CDK13 BTF3 NCBP1 PRPF38B CDK11B LYAR THRAP3 IWS1

2.42e-091014841632416067
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

ZNF512B PPIG BTF3L4 BBX TSR1 CDK12 STK38 NCBP1 SRSF11 PRPF38B SREK1 CDK11B LYAR THRAP3 RBM39 IWS1

6.06e-091082841638697112
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

PPIG RAD18 CDK12 CLK2 NCBP1 PRPF38B CDK11B THRAP3 IWS1

1.06e-0825184931076518
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

PPIG BBX TSR1 CDK12 NCBP1 SRSF11 PRPF38B SREK1 CDK11B LYAR THRAP3 RBM39

1.48e-07713841229802200
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

CCM2 FAM193A ARID4B CADPS BTF3 CHCHD6 TNKS RBM39 CAVIN2 IWS1

2.30e-07475841031040226
Pubmed

Insights into the ubiquitin-proteasome system of human embryonic stem cells.

PPIG CDK12 CLK2 BTF3 SRSF11 PRPF38B SREK1 RBM39

3.03e-0726984829511261
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

ZNF512B RAD18 BBX ARID4B CDK12 MLLT1 SRSF11 ZDBF2 SREK1 CDK11B LYAR THRAP3 RBM39

4.75e-07954841336373674
Pubmed

Expression of testicular germ cell genes identified by differential display analysis.

ANKRD20A4P ANKRD20A8P ANKRD20A1

7.54e-07884312634303
Pubmed

The protein interaction landscape of the human CMGC kinase group.

RTF1 PPIG CCM2 DSC1 CDK12 CLK2 CDK13 MLLT1 SREK1 THRAP3 RBM39

9.28e-07695841123602568
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

DCAF13 BBX CLCN3 CLCN4 CDK13 MLLT1 NCBP1 KDR SRSF11 SREK1 SLC4A3 THRAP3 ARHGAP21 CAVIN2 RBFA

1.72e-061442841535575683
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ZNF512B RAD18 BBX ARID4B TSR1 NCBP1 CDK11B LYAR ZNF649 IWS1

2.14e-06608841036089195
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

RTF1 PPIG TSR1 CLK2 DGKB SRSF11 PRPF38B SORBS1 SREK1 CDK11B LYAR PKD1L3 STK38L THRAP3

2.31e-061284841417353931
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ZNF512B TAF6L CASP8AP2 PPIG RAD18 BBX ARID4B CDK13 MLLT1 SRSF11 LYAR THRAP3 RBM39 IWS1

2.53e-061294841430804502
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

UBR1 PPIG RAD18 ARID4B CDK12 CDK13 PRPF38B CDK11B TOPORS THRAP3 IWS1

2.62e-06774841115302935
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

ARFGEF3 PPIG CDK12 CDK13 SRSF11 PRPF38B THRAP3 RBM39

2.74e-0636184826167880
Pubmed

Cyclin-dependent kinases: a family portrait.

CDK12 CDK13 CDK11B

2.94e-061284319884882
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

PPIG DCAF13 CDK13 BTF3 NCBP1 SRSF11 SREK1 CDK11B LYAR THRAP3 RBM39

3.91e-06807841122681889
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

DSC1 STK38 MLLT1 ZDBF2 STK38L THRAP3 RBM39

4.49e-0627284731010829
Pubmed

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

FAM193A TSR1 CDK12 CDK13 NCBP1 SRSF11 SREK1 LYAR THRAP3 RBM39

5.60e-06678841030209976
Pubmed

Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.

CLCN3 CLCN4

5.76e-06284232118314
Pubmed

NDR functions as a physiological YAP1 kinase in the intestinal epithelium.

STK38 STK38L

5.76e-06284225601544
Pubmed

Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup.

TMEM183A TMEM183BP

5.76e-06284216644869
Pubmed

EGR3 as a potential susceptibility gene for schizophrenia in Korea.

EGR2 EGR3

5.76e-06284220687139
Pubmed

Human CDK12 and CDK13, multi-tasking CTD kinases for the new millenium.

CDK12 CDK13

5.76e-06284230319007
Pubmed

Egr-2 and Egr-3 are negative regulators of T cell activation.

EGR2 EGR3

5.76e-06284215834410
Pubmed

Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.

EGR2 EGR3

5.76e-06284229314730
Pubmed

Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing.

CDK12 CDK13

5.76e-06284225561469
Pubmed

Preferential association with ClC-3 permits sorting of ClC-4 into endosomal compartments.

CLCN3 CLCN4

5.76e-06284228972156
Pubmed

NFκB and MAPK signalling pathways mediate TNFα-induced Early Growth Response gene transcription leading to aromatase expression.

EGR2 EGR3

5.76e-06284223485457
Pubmed

Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.

CDK12 CDK13

5.76e-06284224999027
Pubmed

Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer.

CDK12 CDK13

5.76e-06284235857807
Pubmed

Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease.

SP140L SP140

5.76e-06284236130593
Pubmed

The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells.

EGR2 EGR3

5.76e-06284223021953
Pubmed

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

EGR2 EGR3

5.76e-06284228487311
Pubmed

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.

CDK12 CDK13

5.76e-06284220952539
Pubmed

Emerging roles of Egr2 and Egr3 in the control of systemic autoimmunity.

EGR2 EGR3

5.76e-06284227856665
Pubmed

Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1high memory phenotype CD4 T cells.

EGR2 EGR3

5.76e-06284232709717
Pubmed

Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein.

STK38 STK38L

5.76e-06284215037617
Pubmed

Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases.

SP140L SP140

5.76e-06284235952671
Pubmed

The role of Sp140 revealed in IgE and mast cell responses in Collaborative Cross mice.

SP140L SP140

5.76e-06284234156030
Pubmed

Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.

EGR2 EGR3

5.76e-06284236342511
Pubmed

A comprehensive resource of interacting protein regions for refining human transcription factor networks.

PPIG ARID4B HES4 SRSF11 SREK1 ARHGAP21

7.22e-0619184620195357
Pubmed

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.

DCAF13 CLK2 CDK13 BTF3 SRRM4 SRSF11 PRPF38B SREK1 LYAR THRAP3

9.80e-06723841034133714
Pubmed

Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.

STK38 STK38L THRAP3

1.08e-051884320064376
Pubmed

STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.

IPO8 TSR1 STK38 SRSF11 CDK11B LYAR RBM39

1.19e-0531684731665637
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

ARFGEF3 FAM193A BTF3 CEP131 ZDBF2 ARHGAP21

1.21e-0520984636779422
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

ARFGEF3 CASP8AP2 RAD18 CEP131 ZDBF2 SORBS1 CDK11B CGNL1 TOPORS

1.27e-0558884938580884
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

TAF6L BTF3L4 BBX TSR1 CDK12 CDK13 BTF3 MLLT1 PRPF38B CEP131 SREK1 LYAR RBFA IWS1

1.33e-051497841431527615
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

ZNF512B DSC1 TSR1 NCBP1 CDK11B LYAR THRAP3 RBM39 IWS1

1.59e-0560584928977666
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

PPIG DCAF13 TSR1 CLK2 BTF3 NCBP1 SRSF11 PRPF38B SREK1 CDK11B LYAR THRAP3 RBM39

1.61e-051318841330463901
Pubmed

Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability.

STK38 STK38L

1.73e-05384221262772
Pubmed

E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6.

UBR1 RAD18

1.73e-05384221422291
Pubmed

Early growth response transcriptional regulators are dispensable for macrophage differentiation.

EGR2 EGR3

1.73e-05384217312150
Pubmed

Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.

EGR2 EGR3

1.73e-05384215173177
Pubmed

Cyclin D1 promotes cell cycle progression through enhancing NDR1/2 kinase activity independent of cyclin-dependent kinase 4.

STK38 STK38L

1.73e-05384223897809
Pubmed

Early growth response genes 2 and 3 induced by AP-1 and NF-κB modulate TGF-β1 transcription in NK1.1- CD4+ NKG2D+ T cells.

EGR2 EGR3

1.73e-05384233011290
Pubmed

Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint.

EGR2 EGR3

1.73e-05384235045301
Pubmed

Egr2 and 3 Inhibit T-bet-Mediated IFN-γ Production in T Cells.

EGR2 EGR3

1.73e-05384228455436
Pubmed

Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production.

EGR2 EGR3

1.73e-05384227911796
Pubmed

Early Growth Response Genes 2 and 3 Regulate the Expression of Bcl6 and Differentiation of T Follicular Helper Cells.

EGR2 EGR3

1.73e-05384225979336
Pubmed

Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice.

DSC1 SPINK5

1.73e-05384215466487
Pubmed

HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases.

STK38 STK38L

1.73e-05384215582665
Pubmed

CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1.

CDK12 CDK13

1.73e-05384237026485
Pubmed

Epidermal-growth-factor-induced proliferation of astrocytes requires Egr transcription factors.

EGR2 EGR3

1.73e-05384219706684
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

ZNF512B TAF6L BBX ARID4B TSR1 NCBP1 CEP131 THRAP3 IWS1

2.62e-0564584925281560
Pubmed

UPF2 is a critical regulator of liver development, function and regeneration.

TMEM183A TMEM183BP RBM39

2.65e-052484320657840
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

PPIG FAM193A BBX CDK13 SRSF11 SREK1 LYAR THRAP3 RBM39

2.96e-0565584935819319
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

RAD18 DCAF13 ERCC4 IPO8 DSC1 SP140L CDK12 NCBP1 PRPF38B TNKS TOPORS THRAP3

3.16e-051203841229180619
Pubmed

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons.

SP140L SP140

3.45e-05484234151776
Pubmed

An amphioxus Krox gene: insights into vertebrate hindbrain evolution.

EGR2 EGR3

3.45e-05484211180801
Pubmed

Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation.

CLCN3 CLCN4

3.45e-05484220351103
Pubmed

NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis.

STK38 STK38L

3.45e-05484219062280
Pubmed

Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein.

STK38 STK38L

3.45e-05484215197186
Pubmed

EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin.

EGR2 EGR3

3.45e-05484220506119
Pubmed

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.

CDK12 CDK13

3.45e-05484222012619
Pubmed

Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse.

EGR2 EGR3

3.45e-05484211891986
Pubmed

Charting the landscape of tandem BRCT domain-mediated protein interactions.

RAD18 DCAF13 TSR1 CDK12 CDK13 NCBP1 LYAR THRAP3 RBM39

3.52e-0567084922990118
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

CASP8AP2 TSR1 SRGAP1 SORBS1 ARHGAP21

3.60e-0515384510718198
Pubmed

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.

PPIG CLK2 STK38 PRPF38B STK38L THRAP3

3.69e-0525584615324660
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

PPIG BTF3L4 IPO8 TSR1 BTF3 SORBS1 CGNL1 LYAR RBM39 ARHGAP21

4.01e-05853841028718761
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ARFGEF3 BTF3L4 CLK2 CDK13 LRP5 CHCHD6 SRSF11 PRPF38B TMEM183BP STK38L THRAP3 RBM39 WNK2

5.68e-051489841328611215
Pubmed

Integrated analysis of DNA methylation and RNA‑sequencing data in Down syndrome.

EGR2 EGR3

5.74e-05584227667480
Pubmed

Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity.

PIEZO2 EGR3

5.74e-05584232576830
Pubmed

Egr2-independent, Klf1-mediated induction of PD-L1 in CD4+ T cells.

EGR2 EGR3

5.74e-05584229728568
Pubmed

Ndr kinases regulate retinal interneuron proliferation and homeostasis.

STK38 STK38L

5.74e-05584230135513
Pubmed

Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3.

EGR2 EGR3

5.74e-05584218203138
Pubmed

HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter.

EGR2 EGR3

5.74e-05584211909874
Pubmed

Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.

CDK12 CDK13

5.74e-05584222547058
Pubmed

Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity.

EGR2 EGR3

5.74e-05584230012846
Pubmed

Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases.

STK38 STK38L

5.74e-05584215067004
Pubmed

The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells.

EGR2 EGR3

5.74e-05584219169262
Pubmed

An essential role for ClC-4 in transferrin receptor function revealed in studies of fibroblasts derived from Clcn4-null mice.

CLCN3 CLCN4

5.74e-05584219339555
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

CDK12 CLK2 CDK13 STK38 DGKB CDK11B STK38L THRAP3 WNK2

6.82e-0573084934857952
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

RTF1 CDK12 CLK2 CDK13 STK38 MLLT1 CDK11B STK38L THRAP3 ARHGAP21

6.88e-05910841036736316
Pubmed

Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.

PPIG DSC1 CDK12 NCBP1 SRSF11 PRPF38B LYAR THRAP3 RBM39

6.89e-0573184929298432
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

ZNF512B BTF3L4 FAM193A DSC1 CDK12 BTF3 PRPF38B CGNL1 RBM39 ARHGAP21

8.53e-05934841033916271
Pubmed

A series of xanthenes inhibiting Rad6 function and Rad6-Rad18 interaction in the PCNA ubiquitination cascade.

UBR1 RAD18

8.59e-05684235355521
Pubmed

Expression of CLCN voltage-gated chloride channel genes in human blood vessels.

CLCN3 CLCN4

8.59e-05684210198195
Pubmed

Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex.

CCM2 KDR

8.59e-05684226235885
Pubmed

Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration.

STK38 STK38L

8.59e-05684236446521
InteractionCLK3 interactions

PPIG RAD18 CLK2 MLLT1 NCBP1 SRSF11 PRPF38B LYAR TOPORS THRAP3 RBM39

1.89e-092208411int:CLK3
InteractionSRPK2 interactions

RTF1 ARFGEF3 PPIG RAD18 CCM2 CDK12 CLK2 CDK13 BTF3 NCBP1 SRSF11 PRPF38B SREK1 LYAR THRAP3 RBM39 CAVIN2

5.35e-097178417int:SRPK2
InteractionSRSF4 interactions

PPIG RAD18 CDK12 CLK2 CDK13 SRRM4 SRSF11 SREK1 TOPORS THRAP3 RBM39

4.69e-083008411int:SRSF4
InteractionDDX23 interactions

RTF1 ZNF512B PPIG RAD18 CDK12 CDK13 MLLT1 SRSF11 SREK1 LYAR THRAP3 RBM39 IWS1

9.06e-084808413int:DDX23
InteractionEZH1 interactions

PHF1 DCAF13 CDK12 STK38 PRPF38B ZNF518B CDK11B

1.12e-0792847int:EZH1
InteractionLINC02910 interactions

RTF1 PPIG DCAF13 CDK12 PRPF38B SREK1 CDK11B

1.39e-0795847int:LINC02910
InteractionSNIP1 interactions

RTF1 PPIG RAD18 CCM2 DCAF13 CLK2 CDK13 BTF3 SRRM4 NCBP1 TOPORS THRAP3

1.55e-074178412int:SNIP1
InteractionSRSF6 interactions

PPIG BBX CDK12 CLK2 CDK13 BTF3 SRSF11 PRPF38B SREK1 CDK11B TOPORS THRAP3 RBM39

1.55e-075038413int:SRSF6
InteractionSRSF11 interactions

PPIG CLK2 SRRM4 SRSF11 PRPF38B SREK1 THRAP3 RBM39 RBFA

1.71e-07203849int:SRSF11
InteractionSAP18 interactions

PPIG RAD18 ARID4B CLK2 SRSF11 PRPF38B SREK1 TOPORS THRAP3 RBM39

5.59e-073058410int:SAP18
InteractionANAPC15 interactions

ZNF512B PPIG BBX CDK12 PRPF38B CDK11B RBFA

1.07e-06128847int:ANAPC15
InteractionSRPK3 interactions

CLK2 CDK13 NCBP1 SRSF11 SREK1 LYAR THRAP3 RBM39

1.27e-06190848int:SRPK3
InteractionSNRNP70 interactions

PPIG BBX TSR1 CDK12 CLK2 BTF3 SRGAP1 SRRM4 NCBP1 SRSF11 PRPF38B SREK1 CDK11B LYAR THRAP3 RBM39

2.58e-069848416int:SNRNP70
InteractionPIP4K2A interactions

RTF1 PPIG RAD18 DCAF13 MLLT1 PRPF38B LYAR IWS1

3.32e-06216848int:PIP4K2A
InteractionCLK1 interactions

PPIG CDK12 CLK2 SRRM4 MLLT1 SRSF11 THRAP3 RBM39

3.67e-06219848int:CLK1
InteractionCDK8 interactions

TAF6L RAD18 ARID4B CDK12 SRGAP1 STK38 CDK11B THRAP3

4.06e-06222848int:CDK8
InteractionMECP2 interactions

ZNF512B PPIG BTF3L4 DCAF13 BBX TSR1 CDK12 BTF3 STK38 NCBP1 SRSF11 PRPF38B SREK1 CDK11B LYAR THRAP3 RBM39 IWS1

4.66e-0612878418int:MECP2
InteractionZCCHC10 interactions

PPIG BBX CDK12 CLK2 SRSF11 SREK1 TOPORS RBM39

6.37e-06236848int:ZCCHC10
InteractionLUC7L interactions

PPIG RAD18 CLK2 SRRM4 NCBP1 SRSF11 PRPF38B THRAP3

7.65e-06242848int:LUC7L
InteractionRBBP7 interactions

ZNF512B PHF1 RAD18 ARID4B DSC1 BTF3 PRPF38B CDK11B TOPORS THRAP3 RBM39

8.12e-065078411int:RBBP7
InteractionBCLAF1 interactions

RAD18 CDK12 CLK2 BTF3 SRSF11 CDK11B THRAP3 RBM39 IWS1

8.84e-06327849int:BCLAF1
InteractionPRP4K interactions

RAD18 RHOBTB1 TSR1 CDK12 CLK2 NCBP1 SRSF11 THRAP3 RBM39

9.28e-06329849int:PRP4K
InteractionRNPS1 interactions

PPIG CDK12 CLK2 SRRM4 SRSF11 SREK1 CDK11B TOPORS THRAP3 RBM39

1.07e-054258410int:RNPS1
InteractionSUPT16H interactions

RTF1 RAD18 RHOBTB1 CDK12 BTF3 KDR SREK1 CDK11B RBM39 IWS1

1.51e-054428410int:SUPT16H
InteractionTHRAP3 interactions

PPIG RAD18 CDK12 CLK2 BTF3 SRSF11 SREK1 THRAP3 RBM39 CAVIN2

1.54e-054438410int:THRAP3
InteractionZNF330 interactions

RTF1 ZNF512B RAD18 BBX ARID4B IPO8 TSR1 MLLT1 LYAR IWS1

1.63e-054468410int:ZNF330
InteractionSRRM4 interactions

SRRM4 SRSF11 SREK1 RBM39

1.67e-0537844int:SRRM4
InteractionTERF2IP interactions

RTF1 ZNF512B TAF6L RAD18 ERCC4 BBX CDK12 CDK13 NCBP1 SRSF11 SREK1

1.79e-055528411int:TERF2IP
InteractionNKAP interactions

PPIG RAD18 CDK11B LYAR TOPORS RBM39

1.88e-05132846int:NKAP
InteractionRAD18 interactions

PPIG RAD18 CDK12 CLK2 SRGAP1 NCBP1 PRPF38B CDK11B THRAP3 IWS1

2.01e-054578410int:RAD18
InteractionSRSF1 interactions

PPIG TSR1 CDK12 CLK2 CDK13 BTF3 SRSF11 SREK1 LYAR THRAP3 RBM39

2.41e-055708411int:SRSF1
InteractionPARP1 interactions

RTF1 ZNF512B TAF6L BPNT2 RAD18 ERCC4 BBX ARID4B CDK13 BTF3 MLLT1 SREK1 CGNL1 LYAR TOPORS THRAP3 RBM39

2.52e-0513168417int:PARP1
InteractionIK interactions

RAD18 CDK12 SRSF11 ZDBF2 CDK11B THRAP3 RBM39

3.22e-05215847int:IK
InteractionACIN1 interactions

RAD18 CLK2 KDR SRSF11 THRAP3 RBM39 CAVIN2 IWS1

3.68e-05301848int:ACIN1
InteractionPNN interactions

PPIG CLK2 BTF3 SRSF11 SREK1 TOPORS THRAP3 RBM39

3.77e-05302848int:PNN
InteractionCSNK2A1 interactions

RTF1 BTF3L4 RAD18 ARID4B TSR1 CDK12 CLK2 MLLT1 SRSF11 SREK1 CDK11B THRAP3 RBM39 IWS1

3.80e-059568414int:CSNK2A1
InteractionSHPRH interactions

ZNF512B PHF1 RAD18 BBX ARID4B

5.32e-0597845int:SHPRH
InteractionYWHAE interactions

RAD18 IPO8 CDK12 CDK13 BTF3 SRGAP1 NCBP1 CEP131 SORBS1 CDK11B CGNL1 STK38L PLEKHG5 RBM39 ARHGAP21 WNK2

5.37e-0512568416int:YWHAE
InteractionNUP43 interactions

RTF1 CASP8AP2 BBX ARID4B DSC1 CDK12 ZDBF2 SREK1 CDK11B RBM39 IWS1

5.57e-056258411int:NUP43
InteractionPNISR interactions

RAD18 SRSF11 CDK11B RBM39

6.04e-0551844int:PNISR
InteractionH3-3A interactions

ZNF512B RAD18 BBX ARID4B TSR1 BTF3 NCBP1 CDK11B LYAR ZNF649 THRAP3 IWS1

6.17e-057498412int:H3-3A
InteractionZC3H18 interactions

RTF1 PPIG RAD18 DSC1 CDK12 CLK2 NCBP1 SRSF11 PRPF38B LYAR TOPORS THRAP3 RBM39

6.56e-058778413int:ZC3H18
InteractionTRA2A interactions

PPIG RAD18 CLK2 BTF3 KDR SRSF11 THRAP3 RBM39

7.02e-05330848int:TRA2A
InteractionUQCR11 interactions

DCAF13 CDK12 PRPF38B CDK11B

7.04e-0553844int:UQCR11
InteractionJARID2 interactions

PHF1 STK38 STK38L THRAP3

7.58e-0554844int:JARID2
InteractionIFI6 interactions

PPIG CDK12 PRPF38B SREK1

7.58e-0554844int:IFI6
InteractionCFAP141 interactions

DCAF13 PRPF38B CDK11B IWS1

8.15e-0555844int:CFAP141
InteractionMTA3 interactions

ZNF512B PHF1 ARID4B CDK13 BTF3 CDK11B

8.57e-05173846int:MTA3
InteractionH3C1 interactions

ZNF512B PHF1 TAF6L BTF3L4 RAD18 PIEZO2 BBX ARID4B TSR1 CDK13 BTF3 MLLT1 THRAP3

8.62e-059018413int:H3C1
InteractionANKRD50 interactions

PPIG CDK12 PRPF38B CEP131 CDK11B

8.88e-05108845int:ANKRD50
InteractionARL6IP4 interactions

RAD18 SRRM4 SRSF11 SREK1 RBM39

9.28e-05109845int:ARL6IP4
InteractionARHGAP42 interactions

BTF3 SRGAP1 SORBS1 ARHGAP21

1.15e-0460844int:ARHGAP42
InteractionRPL31 interactions

RTF1 ZNF512B BTF3L4 RAD18 BBX TSR1 BTF3 SREK1 LYAR RBM39 IWS1

1.18e-046808411int:RPL31
InteractionGPATCH8 interactions

CLK2 SRSF11 CDK11B RBM39 RBFA

1.20e-04115845int:GPATCH8
InteractionSSRP1 interactions

RTF1 RAD18 RHOBTB1 BTF3 NCBP1 SREK1 LYAR THRAP3 RBM39 CAVIN2 IWS1

1.26e-046858411int:SSRP1
InteractionSRRM2 interactions

RTF1 RAD18 CDK12 CLK2 BTF3 SRSF11 LYAR RBM39 IWS1

1.30e-04462849int:SRRM2
InteractionRBBP4 interactions

ZNF512B PHF1 RAD18 BBX ARID4B BTF3 CDK11B TOPORS THRAP3 RBM39

1.33e-045738410int:RBBP4
InteractionGSK3A interactions

ARFGEF3 FAM193A TSR1 BTF3 CEP131 ZDBF2 TOPORS THRAP3 ARHGAP21

1.34e-04464849int:GSK3A
InteractionH2BC8 interactions

RTF1 ZNF512B RAD18 ERCC4 BBX ARID4B TSR1 NCBP1 LYAR IWS1

1.39e-045768410int:H2BC8
InteractionTOP1 interactions

RAD18 DCAF13 ARID4B TSR1 BTF3 NCBP1 SRSF11 TOPORS THRAP3 RBM39 IWS1

1.45e-046968411int:TOP1
InteractionIFI27L1 interactions

DCAF13 CDK12 PRPF38B SREK1

1.57e-0465844int:IFI27L1
InteractionHDGFL2 interactions

RTF1 RAD18 TSR1 MLLT1 CDK11B IWS1

1.61e-04194846int:HDGFL2
InteractionCLK2 interactions

RAD18 CLK2 MLLT1 SRSF11 THRAP3 RBM39

1.65e-04195846int:CLK2
InteractionSRPK1 interactions

PPIG RAD18 ARID4B NCBP1 SRSF11 SREK1 LYAR THRAP3 RBM39

1.65e-04477849int:SRPK1
InteractionSNRPA interactions

PPIG RAD18 CLK2 NCBP1 SRSF11 LYAR THRAP3 RBM39 IWS1

1.79e-04482849int:SNRPA
InteractionYWHAG interactions

PPIG CDK12 CLK2 BTF3 SRGAP1 KDR SRSF11 PRPF38B CEP131 SORBS1 CDK11B CGNL1 PLEKHG5 THRAP3 ARHGAP21

1.81e-0412488415int:YWHAG
InteractionPPIG interactions

PPIG RAD18 SRSF11 THRAP3 RBM39

1.90e-04127845int:PPIG
InteractionMYO1E interactions

RAD18 BTF3 MLLT1 THRAP3 ARHGAP21 CAVIN2

2.00e-04202846int:MYO1E
InteractionPRPH interactions

STK38 C19orf44 SORBS1 STK38L RBM39 ARHGAP21

2.11e-04204846int:PRPH
InteractionJMJD6 interactions

PPIG SRSF11 PRPF38B SREK1 CDK11B RBM39

2.16e-04205846int:JMJD6
InteractionAPEX1 interactions

RTF1 ZNF512B PHF1 RAD18 FAM193A BBX CLCN3 ARID4B CDK13 CEP131 LYAR ABLIM3 PLEKHG5 THRAP3 IWS1

2.21e-0412718415int:APEX1
InteractionLLGL2 interactions

RAD18 NCBP1 TOPORS THRAP3 IWS1

2.36e-04133845int:LLGL2
InteractionSMC5 interactions

ZNF512B RAD18 BBX ARID4B CDK12 MLLT1 SRSF11 ZDBF2 SREK1 CDK11B LYAR THRAP3 RBM39

2.42e-0410008413int:SMC5
InteractionHERC2 interactions

PPIG CDK12 CLK2 BTF3 SRSF11 PRPF38B SORBS1 SREK1 RBM39

2.45e-04503849int:HERC2
InteractionANKRD20A4P interactions

ANKRD20A4P ANKRD20A1

2.55e-046842int:ANKRD20A4P
InteractionHDAC4 interactions

CCM2 FAM193A ARID4B EGR2 CADPS BTF3 TNKS THRAP3 RBM39 CAVIN2 IWS1

2.57e-047448411int:HDAC4
InteractionCTNNB1 interactions

RAD18 FAM193A EGR2 BTF3 LRP5 KDR PRPF38B TNKS SORBS1 CGNL1 THRAP3 RBM39 ARHGAP21

2.64e-0410098413int:CTNNB1
InteractionPSPC1 interactions

BTF3L4 DCAF13 TSR1 CDK13 SRGAP1 NCBP1 LYAR RBM39 ARHGAP21

2.91e-04515849int:PSPC1
InteractionSRSF3 interactions

PPIG CDK12 CLK2 CDK13 BTF3 SRSF11 SREK1 THRAP3 RBM39

3.22e-04522849int:SRSF3
InteractionSF3B5 interactions

TAF6L RAD18 RHOBTB1 RBM39 IWS1

3.30e-04143845int:SF3B5
InteractionCDX1 interactions

CDK12 CLK2 BTF3 SREK1

3.49e-0480844int:CDX1
InteractionANKRD20A2P interactions

ANKRD20A4P ANKRD20A1

3.56e-047842int:ANKRD20A2P
InteractionUBE2A interactions

RTF1 ZNF512B UBR1 RAD18 TSR1 THRAP3

3.65e-04226846int:UBE2A
InteractionPSENEN interactions

PPIG DCAF13 PRPF38B CDK11B

3.66e-0481844int:PSENEN
InteractionCDK12 interactions

RAD18 CDK12 CDK13 MLLT1 THRAP3 RBM39

3.83e-04228846int:CDK12
InteractionBARD1 interactions

TSR1 CDK12 CDK13 NCBP1 TNKS THRAP3 RBM39

4.01e-04323847int:BARD1
InteractionRHOBTB1 interactions

TAF6L RHOBTB1 STK38 NCBP1 CEP131

4.37e-04152845int:RHOBTB1
InteractionRC3H2 interactions

FAM193A TSR1 CDK12 CDK13 NCBP1 SRSF11 SREK1 LYAR THRAP3 RBM39

4.48e-046678410int:RC3H2
InteractionRC3H1 interactions

FAM193A TSR1 CDK12 STK38 NCBP1 SREK1 LYAR STK38L THRAP3 RBM39

5.04e-046778410int:RC3H1
InteractionNKAPD1 interactions

PPIG CLK2 NCBP1 THRAP3 RBM39

5.68e-04161845int:NKAPD1
InteractionPRPF38A interactions

PPIG RAD18 CLK2 SRRM4 RBM39

5.68e-04161845int:PRPF38A
InteractionHNRNPCL1 interactions

PPIG CLK2 NCBP1 SREK1 THRAP3

5.68e-04161845int:HNRNPCL1
InteractionSRGAP1 interactions

RAD18 SRGAP1 SORBS1 ARHGAP21

5.94e-0492844int:SRGAP1
InteractionZRSR2P1 interactions

RAD18 SRRM4

6.06e-049842int:ZRSR2P1
InteractionNOP56 interactions

RTF1 RAD18 DCAF13 TSR1 BTF3 MLLT1 CDK11B LYAR RBM39

6.08e-04570849int:NOP56
InteractionPPP1R15A interactions

ZNF512B BBX PPP1R15A

6.17e-0440843int:PPP1R15A
InteractionMAGEB2 interactions

PPIG BBX CDK12 CDK13 SREK1 CDK11B LYAR

6.36e-04349847int:MAGEB2
InteractionINO80B interactions

TSR1 SRSF11 PRPF38B SREK1 RBM39

6.70e-04167845int:INO80B
InteractionLUC7L2 interactions

CADPS CLK2 SRRM4 SRSF11 SREK1 THRAP3 RBM39

6.80e-04353847int:LUC7L2
InteractionSRSF8 interactions

RAD18 CLK2 SREK1 THRAP3

7.53e-0498844int:SRSF8
GeneFamilyCyclin dependent kinases

CDK12 CDK13 CDK11B

5.90e-0526533496
GeneFamilyChloride voltage-gated channels

CLCN3 CLCN4

3.74e-0410532302
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

PARP16 TNKS

1.11e-0317532684
GeneFamilyPHD finger proteins

PHF1 SP140L SP140

2.33e-039053388
CoexpressionGSE3720_VD1_VS_VD2_GAMMADELTA_TCELL_WITH_PMA_STIM_UP

ZNF512B PPIG EGR3 CDK13 ZNF518B STK38L IWS1

3.74e-06200847M6356
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_CORRELATED_WITH_HAI_28DY_RESPONSE_AT_3DY_NEGATIVE

ZNF512B PPIG BBX CDK12 SRSF11 TNKS RBM39 CAVIN2

2.19e-05363848M41103
CoexpressionBENPORATH_SOX2_TARGETS

UBR1 BTF3L4 ARID4B EGR3 CDK12 NCBP1 KDR CEP131 PPP1R15A RBM39 IWS1

2.23e-057348411M3835
CoexpressionGSE27786_CD4_TCELL_VS_ERYTHTROBLAST_UP

ZNF512B PPIG CDK13 LMNTD2 LYAR RBFA

4.54e-05200846M4827
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

CASP8AP2 PPIG RAD18 PIEZO2 BBX ARID4B SRSF11 PRPF38B SREK1 IWS1

4.70e-056568410M18979
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_3DY_DN

ZNF512B PHF1 BBX CDK12 ZDBF2 SREK1 CDK11B RBM39

7.45e-05432848M41149
CoexpressionHOUNKPE_HOUSEKEEPING_GENES

RTF1 BTF3L4 IPO8 TMEM183A TSR1 BTF3 STK38 NCBP1 SRSF11 TMEM183BP TNKS THRAP3 IWS1

7.73e-0511588413MM1338
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000_k-means-cluster#2

CASP8AP2 PPIG FAM193A ARID4B CLK2 SRGAP1 PRPF38B CDK11B LYAR ARHGAP21 IWS1

3.53e-083118311Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000_K2
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000

CASP8AP2 PPIG FAM193A CLCN3 ARID4B CLK2 SRGAP1 SRRM4 DGKB NCBP1 SRSF11 PRPF38B ZDBF2 CDK11B LYAR ARHGAP21 WNK2 IWS1

3.88e-089898318Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_LatNas_2500_K3

CASP8AP2 PPIG BTF3L4 RAD18 FAM193A ARID4B IPO8 CLK2 SRSF11 PRPF38B ZDBF2 ZNF518B SREK1 CDK11B LYAR TOPORS THRAP3 ARHGAP21 IWS1

2.80e-0712578319facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_LatNas_2500

CASP8AP2 PPIG BTF3L4 RAD18 FAM193A ARID4B IPO8 CLK2 SRSF11 PRPF38B ZDBF2 ZNF518B SREK1 CDK11B LYAR TOPORS THRAP3 ARHGAP21 IWS1

2.63e-0614598319facebase_RNAseq_e10.5_Emin_LatNas_2500
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3

CASP8AP2 BBX TSR1 CDK12 NCBP1 ZDBF2 ZNF518B LYAR TOPORS THRAP3 IWS1

6.97e-065328311Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500_k-means-cluster#3

CASP8AP2 NCBP1 PRPF38B ZDBF2 CDK11B LYAR IWS1

1.03e-05192837Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500_K3
CoexpressionAtlasEB amniotic fluid MSC_vs_EB blastocyst-Confounder_removed-fold2.0_adjp0.05

EGR2 EGR3 CADPS SRRM4 HES4 LMNTD2 ZDBF2 SMPD3 PPP1R15A PLEKHG5 SLC4A3 WNK2

2.47e-057278312PCBC_ratio_EB amniotic fluid MSC_vs_EB blastocyst_cfr-2X-p05
CoexpressionAtlasFacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#1

BBX TSR1 CDK12 PRPF38B CDK11B PPP1R15A LYAR TOPORS IWS1

8.96e-05469839Facebase_RNAseq_e8.5_Floor Plate_2500_K1
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_2500_k-means-cluster#5

CASP8AP2 PPIG FAM193A CLK2 SRGAP1 DGKB NCBP1 ZDBF2 CDK11B LYAR ARHGAP21 IWS1

8.98e-058318312Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_2500_K5
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_500_k-means-cluster#5

CASP8AP2 SRSF11 PRPF38B ZDBF2 CDK11B LYAR

8.99e-05186836Facebase_RNAseq_e10.5_Mandibular Arch_500_K5
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#3_top-relative-expression-ranked_1000

BPNT2 RAD18 STK38 KDR SRSF11 PRPF38B RBM39

1.02e-04275837gudmap_developingGonad_e14.5_ epididymis_1000_k3
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_500_k-means-cluster#4

PPIG PRPF38B CDK11B LYAR TOPORS IWS1

1.07e-04192836Facebase_RNAseq_e10.5_Lateral Nasal Eminence_500_K4
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500

CASP8AP2 SRRM4 NCBP1 SRSF11 PRPF38B ZDBF2 CDK11B LYAR IWS1

1.41e-04498839Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_1000_k-means-cluster#3

PPIG SRGAP1 PRPF38B CDK11B LYAR TOPORS IWS1

1.44e-04291837Facebase_RNAseq_e10.5_Lateral Nasal Eminence_1000_K3
CoexpressionAtlasfacebase_RNAseq_e10.5_NeuroEpith_central_2500_K4

CASP8AP2 PPIG RAD18 ARID4B IPO8 CADPS CLK2 PRPF38B ZDBF2 ZNF518B CDK11B THRAP3 ARHGAP21 WNK2 ZNF710

2.46e-0413708315facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4
CoexpressionAtlasfacebase_RNAseq_e10.5_MandArch_2500_K1

CASP8AP2 PPIG ARID4B CLK2 PRPF38B CEP131 ZDBF2 ZNF518B SREK1 CDK11B PPP1R15A LYAR TOPORS THRAP3

3.01e-0412418314facebase_RNAseq_e10.5_MandArch_2500_K1
CoexpressionAtlasFacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_1000

TAF6L PPIG BBX ARID4B EGR2 SRRM4 SRSF11 PRPF38B CDK11B PPP1R15A LYAR IWS1

4.46e-049898312Facebase_RNAseq_e10.5_Maxillary Arch_1000
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

RTF1 UBR1 CASP8AP2 PPIG ARID4B CDK12 IWS1

6.38e-0818684703db813598b67b1e08f759758a1c2023396921fa
ToppCelldroplet-Tongue-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RTF1 PPIG ARID4B CDK12 SRSF11 PRPF38B RBM39

6.86e-08188847d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCellH1299-infected-SARSCoV2|infected / Cell line, Condition and Strain

RTF1 PPIG SRSF11 PRPF38B SREK1 LYAR RBM39

9.44e-081978470fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASP8AP2 ARID4B CDK12 KDR TNKS CAVIN2

1.11e-0617884601dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARFGEF3 CADPS SRRM4 DGKB SMPD3 WNK2

1.43e-06186846b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARID4B CDK12 KDR SORBS1 THRAP3 CAVIN2

1.83e-06194846e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ARID4B CDK13 SRSF11 ZDBF2 SREK1 RBM39

2.00e-0619784657ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell(08)_Brush+PNEC-(2)_GFP_FOXI1|(08)_Brush+PNEC / shred by cell type by condition

RTF1 PPIG ARID4B CAVIN2 IWS1

6.41e-06138845817e3f639604ea95adae01e8685ffaa2e0aff7a8
ToppCellCOVID-19-Myeloid-MoAM5,_CCL3L1|Myeloid / Condition, Lineage and Cell class

EGR2 EGR3 HES4 PPP1R15A STK38L

1.66e-05168845ea465152ea31391b63c02425beafa9a4f51f6703
ToppCellCOVID-19-Myeloid-MoAM5,_CCL3L1|COVID-19 / Condition, Lineage and Cell class

EGR2 EGR3 HES4 PPP1R15A STK38L

1.92e-05173845502f888b7684ed39f5c577eedcacf673ae81d39e
ToppCellfacs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KDR SORBS1 ABLIM3 PLEKHG5 CAVIN2

1.97e-05174845b1bcd5f4505d2ccef4183fcfbf1de81964b3f9e0
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Pulmonary_neuroendocrine|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 CADPS SRRM4 DGKB SMPD3

2.71e-05186845fcabebdfbf1b1dbb35ce2b3c53a60d2b1aed8e6c
ToppCelldroplet-Bladder-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RTF1 PPIG ARID4B CDK12 RBM39

2.78e-05187845663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

CADPS SORBS1 STK38L SLC4A3 WNK2

2.85e-051888456d249fe92d51a19da19ec14bb2262d394255d577
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARFGEF3 CADPS SRRM4 DGKB SMPD3

2.85e-05188845c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCellfacs-Heart-RA-18m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRGAP1 KDR SORBS1 ABLIM3 CAVIN2

2.93e-051898451be5067c1e45af7d09c1fd6955952cb9e031a3a0
ToppCellfacs-Heart-RA-18m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRGAP1 KDR SORBS1 ABLIM3 CAVIN2

2.93e-0518984530dc1725d43a60017fb12d706f1f85a33de4947e
ToppCellLPS-IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RHOBTB1 KDR SORBS1 ZNF518B CAVIN2

3.00e-05190845106ea0bb7b99c697ffc5443d72343df2484250c7
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB SORBS1 STK38L SLC4A3 WNK2

3.08e-051918458e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCellCOVID-19_Convalescent-PLT_4|COVID-19_Convalescent / Disease Group and Platelet Clusters

ARID4B SREK1 KIAA1586 TOPORS RBM39

3.32e-05194845ce1fad4e76a87f0c35e430ed1f2262395df882fd
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Epithelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EGR2 EGR3 SORBS1 PPP1R15A CAVIN2

3.40e-05195845f41a68b7c2621594db8d8952e301eeadc96be26f
ToppCellCOVID-19_Severe-PLT_4|World / Disease Group and Platelet Clusters

PPIG ARID4B SREK1 KIAA1586 RBM39

3.48e-05196845ad43efdd4d73b6615f65f06a315b33576e317473
ToppCellBronchial_Biopsy-Epithelial-Basal_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

EGR2 EGR3 PPP1R15A CAVIN2 SPINK5

3.57e-0519784561c1c29a62d4c033999b7f0183c1e9cdd6a62925
ToppCell(5)_Dendritic_cell-(53)_Lymphoid_DC|(5)_Dendritic_cell / shred on Cell_type and subtype

PIEZO2 ANKRD20A4P SRGAP1 ARHGAP21 ANKRD20A1

3.65e-05198845548da5fa86f9756c503ed77bcdde55bc4d1a2726
ToppCellCOVID-19_Severe-PLT_4|COVID-19_Severe / Disease Group and Platelet Clusters

PPIG ARID4B SREK1 KIAA1586 RBM39

3.65e-05198845abfddbee99ef8c7719e6e6f62571e9be030e4acf
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CADPS SRRM4 DGKB SMPD3 WNK2

3.65e-051988458f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCellControl-PLT_4|Control / Disease Group and Platelet Clusters

PPIG ARID4B SORBS1 SREK1 KIAA1586

3.65e-05198845387fd3037fd52e4d4c42de0588767e58af228b59
ToppCellwk_08-11-Epithelial-Proximal_epithelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 CADPS SRRM4 SMPD3 SPINK5

3.65e-051988459895f1d65d18d939f3974a914ee41c6d5575e765
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

RTF1 PPIG PRPF38B RBM39 IWS1

3.65e-0519884576d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CADPS SRRM4 DGKB SMPD3 WNK2

3.65e-05198845e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Airway-Club|LPS_only / Treatment groups by lineage, cell group, cell type

ARFGEF3 HES4 KDR WNK2 SPINK5

3.74e-05199845165ac94b2d56072ad43358b5127d77555221e2d8
ToppCellBiopsy_IPF-Epithelial-SCGB3A2+_SCGB1A1+|Biopsy_IPF / Sample group, Lineage and Cell type

ARFGEF3 HES4 KDR WNK2 SPINK5

3.74e-05199845c6150f5fe2ce4466149a4d553acb907034a72efb
ToppCell(04)_Interm._basal>secr.-(2)_GFP_FOXI1|(04)_Interm._basal>secr. / shred by cell type by condition

RTF1 PPIG ARID4B CAVIN2 IWS1

3.74e-0519984553ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Neuronal|GW10 / Sample Type, Dataset, Time_group, and Cell type.

CLCN4 CADPS SRGAP1 SRRM4 PPP1R15A

3.74e-05199845b2508bf591720830e8e3494b1337aab14539956d
ToppCellBronchial-10x5prime-Immune_Myeloid-Myeloid-Megakaryocyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ZNF512B PIEZO2 CADPS ZNF518B ZNF649

3.74e-051998456e7f7214317f2af2ba8523df9896f54b7294d58a
ToppCellBronchial-10x5prime-Immune_Myeloid-Myeloid|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ZNF512B PIEZO2 CADPS ZNF518B ZNF649

3.74e-051998455f499595597c10857bba8272f62afe4d32d733ac
ToppCellBronchial_Brush-Epithelial-Basal_2|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

EGR2 EGR3 HES4 CAVIN2 SPINK5

3.83e-052008451fa29a9f42987549a75dffeb177099458f7cca88
ToppCellTracheal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARFGEF3 SRGAP1 LRP5 CGNL1 WNK2

3.83e-05200845d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCellBronchial_Brush-Epithelial-Basal_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

EGR2 EGR3 HES4 CAVIN2 SPINK5

3.83e-052008457595eb2a8af3de879ecaa71f3d96f890e13b59ce
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ARID4B CDK13 SRSF11 SREK1 RBM39

3.83e-0520084512f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal|GW10 / Sample Type, Dataset, Time_group, and Cell type.

SP140L EGR2 EGR3 KDR CAVIN2

3.83e-052008455c638c80661017c85f9390f1b398ac7728c8f001
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal-BMP_responsible_cell|GW10 / Sample Type, Dataset, Time_group, and Cell type.

SP140L EGR2 EGR3 KDR CAVIN2

3.83e-05200845604a88633d4162337e394155c7346dbdef8b9f5a
ToppCellCOVID-19|World / Disease, condition lineage and cell class

ARID4B CDK13 SREK1 PPP1R15A RBM39

3.83e-052008457dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARFGEF3 SRGAP1 LRP5 CGNL1 WNK2

3.83e-052008450eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCellFetal_29-31_weeks-Immune-dendritic_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CLCN4 ANKRD20A4P SMPD3 ANKRD20A1

1.86e-0415084457f21ad380fd1350a2c25d75ad8c3b763ded53ec
ToppCellPBMC-Control-cDC_8|Control / Compartment, Disease Groups and Clusters

EGR2 EGR3 PARP16 LRP5

2.01e-04153844db1a6914f2033fb0748e0523cffe5d6dc4e901be
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRP5 CHCHD6 SMPD3 SLC4A3

2.22e-0415784419c0599a669803c4db1f174de1ce755e562a50a3
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARFGEF3 CADPS SRRM4 DGKB

2.33e-041598447747cef94c55144fddcd024a7495318357f1351b
ToppCellmoderate-Myeloid-Mast_cell|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PIEZO2 CADPS SORBS1 CAVIN2

2.74e-04166844c3835b424c63bf11a4e2c47635dc3787fc4a637a
ToppCellEndothelial-B-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

PIEZO2 KDR ABLIM3 CAVIN2

2.80e-041678446a03d16165e0b003092c39972928981abd4a75aa
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D175|Adult / Lineage, Cell type, age group and donor

EGR3 CADPS DGKB SORBS1

2.80e-04167844c4e321bb87512ea839f324c92c0f1afea891483f
ToppCell368C-Endothelial_cells-Endothelial-F_(Lymphatics)|368C / Donor, Lineage, Cell class and subclass (all cells)

PIEZO2 LRP5 WNK2 CAVIN2

2.87e-04168844a74c8a9e3299183fba31ce3053ef325b5dbcd104
ToppCell368C-Endothelial_cells-Endothelial-F_(Lymphatics)-|368C / Donor, Lineage, Cell class and subclass (all cells)

PIEZO2 LRP5 WNK2 CAVIN2

2.87e-04168844dae37b316ce80dfe4236c4ed7f0d4e7c340fa7b6
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)|Children_(3_yrs) / Lineage, Cell type, age group and donor

CADPS SRRM4 DGKB WNK2

2.93e-04169844b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCelldroplet-Kidney-nan-3m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIEZO2 SRGAP1 SRRM4 KDR

3.14e-04172844073a503dc922e3e3ac3528e249b0f8b74402110b
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PIEZO2 KDR ABLIM3 CAVIN2

3.21e-041738447dc988fc0ba29990567bf1bcdeb3faeeee507eb1
ToppCellEndothelial-B-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

PIEZO2 KDR ABLIM3 CAVIN2

3.21e-04173844a81992965137195d20fc498f750975303961a828
ToppCelldroplet-Heart-4Chambers-18m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP5 KDR CGNL1 CAVIN2

3.21e-041738449a04271c51fae34f547db3206f9ff5857686e45c
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

RAD18 NCBP1 ZDBF2 SP140

3.35e-0417584406eace2e681980456299167b48bd49bcfea5e940
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)|Adult / Lineage, Cell type, age group and donor

PIEZO2 CADPS SRRM4 DGKB

3.35e-041758444db1a3c284488b3f6de7568363f176d74e2a4587
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.6.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PHF1 CCM2 EGR2 KIAA1586

3.35e-04175844baaffc9af61f12168d6f7b96eb0b6e98a44a3909
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HES4 SORBS1 TOPORS RBM39

3.35e-04175844e99e145a152f534b75267ec492a252a0b814b4f8
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231|Adult / Lineage, Cell type, age group and donor

PIEZO2 CADPS SRRM4 DGKB

3.35e-041758448d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Endothelial-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR PP2D1 ABLIM3 CAVIN2

3.42e-04176844a3f27b5d7edf2d396c085efbe35305cfa0afa565
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Drd1_(Deep_layer_pyramidal_cells)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ARID4B GOLPH3L EGR2 CDK13

3.42e-041768443c76a5c4ca2b378667cb155fbb9675519572b35d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PIEZO2 KDR ABLIM3 CAVIN2

3.50e-04177844c274fbdc141855ff4581d437d4997c64cc193278
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PIEZO2 KDR ABLIM3 CAVIN2

3.50e-04177844f5e6df5cafd003bbfbb3b634ee58d0b1e2be5cc7
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ARFGEF3 HES4 KDR WNK2

3.50e-04177844779ba86f53650772755b52460be03f18bb204e55
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PIEZO2 KDR ABLIM3 CAVIN2

3.50e-04177844c8a51e480b978dc0ded85583261f2c892e085be8
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ARFGEF3 HES4 KDR WNK2

3.50e-041778440f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PIEZO2 KDR ABLIM3 CAVIN2

3.50e-04177844b1775e05c28883a15c56628028770bc59d3233fb
ToppCellfacs-Lung-EPCAM-18m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHF1 MLLT1 SORBS1 CAVIN2

3.50e-041778442433924dcb085ebbe2545d476ebd7ee68e6092fb
ToppCell15-Trachea-Epithelial-Goblet-like_secretory|Trachea / Age, Tissue, Lineage and Cell class

ARFGEF3 KDR WNK2 SPINK5

3.57e-04178844f0557920b9b3e7c4f39938d1b524aa58711af4d2
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PIEZO2 KDR PKD1L3 CAVIN2

3.57e-04178844ad3de3e03a401dac64431a541899445262246347
ToppCellfacs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KDR SORBS1 ABLIM3 CAVIN2

3.57e-04178844a3f95f0002f408b5b6c57e28b297b5b2737e919c
ToppCelldroplet-Heart-4Chambers-18m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP5 KDR ABLIM3 CAVIN2

3.57e-0417884493ce73f8bcec63ebf86fabb546f88400e8f06465
ToppCellfacs-GAT-Fat-18m-Endothelial|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR SORBS1 ABLIM3 CAVIN2

3.65e-04179844d56fa2a0b119d51a8d41b00fbbd7dfddefeb279c
ToppCellfacs-GAT-Fat-18m-Endothelial-endothelial_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR SORBS1 ABLIM3 CAVIN2

3.65e-04179844e0542694fa79d67f67be6f85b4fa6d18f7523253
ToppCellTCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-1|TCGA-Adrenal / Sample_Type by Project: Shred V9

EGR2 EGR3 CADPS SORBS1

3.65e-04179844431e1b29015ec817f778499106d24b19cfc825ae
ToppCell15-Distal-Epithelial-Neuroendocrine|Distal / Age, Tissue, Lineage and Cell class

ARFGEF3 SRRM4 DGKB SMPD3

3.65e-04179844bc04789f0fbd293fdcea66acba8cf227af251b7a
ToppCellfacs-GAT-Fat-18m-Endothelial-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR SORBS1 ABLIM3 CAVIN2

3.65e-0417984483343b68977969c7978acd930a66fc7c44df6a15
ToppCelldroplet-Fat-Gat-18m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RHOBTB1 KDR ABLIM3 PLEKHG5

3.65e-0417984408cf9986804a6417a9afb19b50c69a3554f71ec6
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR CGNL1 PLEKHG5 CAVIN2

3.72e-041808442405aa5699a8d8cf4c6b3dca07510e774728ac50
ToppCellfacs-Lung-EPCAM-18m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHF1 MLLT1 SORBS1 CAVIN2

3.72e-04180844082c6116e0bbba8d9a3a82d14af55bdc8990c8c0
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR CGNL1 PLEKHG5 CAVIN2

3.72e-041808449c47852c0a723e2f5cd6898afff4c31a0da06905
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR CGNL1 PLEKHG5 CAVIN2

3.72e-04180844499d5fe71e0dc20cffdf85e3b3f14eb4e83e3a3d
ToppCellfacs-Lung-EPCAM-18m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHF1 MLLT1 SORBS1 CAVIN2

3.72e-0418084453043d764fad9ac33ee40e356e562e759931adef
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-Tuft-related|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TAF6L HES4 WNK2 ZNF710

3.80e-041818441d3d1b5a6efe9cedd03b7e0b5684df97f0246729
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR ABLIM3 CAVIN2 SPINK5

3.80e-041818440756d7d315b8cdd07a3cf6cdfc8a0679786b8e6a
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR ABLIM3 CAVIN2 SPINK5

3.80e-04181844b09947d2d7b21f96d98b87ceb6f467ea329c4092
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR ABLIM3 CAVIN2 SPINK5

3.80e-041818443f0d88e9506d66d4e71b88c50d5187302065930f
ToppCellPND07-28-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high|PND07-28-samps / Age Group, Lineage, Cell class and subclass

PIEZO2 KDR SORBS1 CAVIN2

3.80e-041818449cd5e5c285c2b628db9d59709af053defd7c0aff
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TAF6L HES4 WNK2 ZNF710

3.80e-041818440069e8308de932df43660bbe926637c57b8bf7f6
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

CADPS SRRM4 DGKB SMPD3

3.88e-0418284457bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CASP8AP2 EGR2 EGR3 ZNF518B

3.88e-041828444a85429d365c4b2d73fc921f261b4b7635ac40bd
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CASP8AP2 EGR2 EGR3 ZNF518B

3.88e-0418284453213af34af3337f5edc734d3b7b79e4349eac0d
ToppCelldroplet-Spleen-nan-18m|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARID4B PPP1R15A RBM39 SP140

3.88e-04182844eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CASP8AP2 EGR2 EGR3 ZNF518B

3.88e-041828447909089ed6325c44edd6f9b7e8b1d542398222ea
ToppCelldroplet-Kidney-nan-3m-Endothelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIEZO2 SRGAP1 KDR CAVIN2

3.88e-04182844f4a5f1c3a04c0566eb96607dab7a0d9a5ebc3fd1
ToppCelldroplet-Spleen-nan-18m-Lymphocytic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARID4B PPP1R15A RBM39 SP140

3.96e-0418384428cbf909424f3be4491d49832f0aca0386560814
DiseaseDent disease (implicated_via_orthology)

CLCN3 CLCN4

2.01e-053772DOID:0050699 (implicated_via_orthology)
Diseaseosteopetrosis (implicated_via_orthology)

CLCN3 CLCN4

1.40e-047772DOID:13533 (implicated_via_orthology)
DiseaseShortened QT interval

LRP5 SLC4A3

3.64e-0411772C0151879
Diseaseautism spectrum disorder

ERCC4 EGR2 CADPS SORBS1

7.54e-04156774EFO_0003756
Diseasediffuse plaque measurement

PHF1 ARFGEF3 SP140L CADPS KDR ZDBF2 ABLIM3 SP140

8.07e-04758778EFO_0010699
DiseaseVan Buchem disease

LRP5 KDR

8.91e-0417772C0432272
Diseasediaphragmatic hernia

PHF1 DGKB

1.37e-0321772EFO_0008561
Diseasecorpus callosum volume measurement

CCM2 ZNF518B WNK2

2.30e-03100773EFO_0010299
Diseasecortex volume change measurement, age at assessment

CGNL1 WNK2

2.43e-0328772EFO_0008007, EFO_0021500
DiseaseNeoplasm of uncertain or unknown behavior of ovary

ERCC4 CDK12

2.61e-0329772C0496920

Protein segments in the cluster

PeptideGeneStartEntry
SRSKERTRHRSDKKK

PRPF4B

186

Q13523
LKKKASSHAVDRLRR

ANKRD20A1

186

Q5TYW2
TAKRLVKVKVTFRHD

ARID4B

31

Q4LE39
RAEKKLKHRRTSETS

ABLIM3

266

O94929
TSARHTRRKRKKEKT

SLC4A3

101

P48751
RRKKKVVHRTATADD

BTF3

71

P20290
HRRSRDLLKAKQTEK

CDK12

116

Q9NYV4
LKKKASTHAVDRLRR

ANKRD20A8P

186

Q5CZ79
KARKTKITHLVRTAD

BBX

826

Q8WY36
KKRDERSVKSTAVRV

CLK2

311

P49760
LKKKASSHAVDRLRR

ANKRD20A4P

186

Q4UJ75
KSRDKKAHEKVTERR

CCM2

26

Q9BSQ5
RDTDRHRKITSKSKE

CLCN4

41

P51793
KDEKRKEKRRHRSHS

CDK11B

101

P21127
RHRTEDKRKREQESK

CASP8AP2

466

Q9UKL3
RKDRDSKAHRSRTKS

CDK13

271

Q14004
TRAAKRARHKQRKLE

FAM193A

866

P78312
KEARRRKEVNRIKHS

DCAF13

411

Q9NV06
TSKKTRKEDHARLRA

RBFA

81

Q8N0V3
RSRSHERKRSKSKER

RBM39

41

Q14498
REEKKESLRSSVHKR

RAD18

226

Q9NS91
KFARSDERKRHTKIH

EGR2

406

P11161
TDIRKKSRSAHAVKI

IWS1

796

Q96ST2
DSREVFKKHIEKRVR

CADPS

206

Q9ULU8
EAKEKLARQHKRRSD

NCBP1

661

Q09161
EKEAKSQKRARHLAR

SPINK5

71

Q9NQ38
RSIERVHKVKASRDV

LRP5

566

O75197
KTTRQASLRKKIREH

KIAA1586

196

Q9HCI6
ASLRKKIREHDVSKA

KIAA1586

201

Q9HCI6
KEHRVRVCRKSVDRS

LMNTD2

586

Q8IXW0
KASVVKKAAARRRRH

SMPD3

326

Q9NY59
VRRVRESNVLHEKSK

BPNT2

81

Q9NX62
DSKEIDRRRARIKHS

PARP16

231

Q8N5Y8
VKDHKSNSKERDIRR

PPIG

426

Q13427
DHSKSKEKDRRAQSR

PPIG

531

Q13427
VHARKEEKEAVSARR

CGNL1

881

Q0VF96
RKKSGRHVTRVLVKD

C19orf44

516

Q9H6X5
KFARSDERKRHAKIH

EGR3

341

Q06889
ARRKKKVVHRTATAD

BTF3L4

21

Q96K17
ESESRKRSISKRKSH

ARFGEF3

386

Q5TH69
HRARRTEISKNSEKK

GOLPH3L

6

Q9H4A5
ESKKRRSHRRIEKKG

DGKB

676

Q9Y6T7
RKESSRHSKLEKADI

HES4

66

Q9HCC6
RKRRHSEVETDSKKK

LYAR

271

Q9NX58
KRHTKDTALKRSKRR

DSC1

121

Q08554
KVTKEHRERPRKDSE

MLLT1

196

Q03111
EKSRKVSAHTRAVKE

CAVIN2

116

O95810
VHRRVKTALARKEEA

CEP131

1036

Q9UPN4
LKARKVRFSEKVTVH

PPP1R15A

551

O75807
DSHAKALERAKKRVT

NPBWR1

236

P48145
TLAEHRRTVAEAKKK

IPO8

996

O15397
SHKDRFISGREIKKR

PHF1

311

O43189
TSHNKERRSKRDEKL

RTF1

261

Q92541
KHTKRRKLTVEDFNR

TAF6L

56

Q9Y6J9
EKRLRRSAHARKETE

STK38

61

Q15208
EEKKLRRSQHARKET

STK38L

61

Q9Y2H1
EERHQRRSSVKKIEK

SRGAP1

206

Q7Z6B7
NIHERTVSRKKKSKR

TMEM183BP

106

Q1AE95
KREREAATKHSKASL

CHCHD6

106

Q9BRQ6
RHKKTKRGVAIARDK

PKD1L3

161

Q7Z443
EKEDIALNKHRSRRK

RHOBTB1

671

O94844
HSRDKRKDTREKIKE

SREK1

256

Q8WXA9
KRVRSRASRKHKDET

SP140L

281

Q9H930
RERHRRINSKKKESA

CLCN3

101

P51790
KKKARRRHTDDPSKE

PLEKHG5

61

O94827
KHKERDLKRGKSRES

THRAP3

726

Q9Y2W1
SKKVRKELSRVDQRH

TSR1

41

Q2NL82
SIHERTVSRKKKSKR

TMEM183A

106

Q8IXX5
KKEEKRRHSRSRSRS

SRSF11

241

Q05519
KEKKHSRSRSRERKH

PRPF38B

421

Q5VTL8
KKLRERFCHRQKEVS

TNKS

1156

O95271
EKRAKDDSRRVVKST

SORBS1

356

Q9BX66
SKRRDEKRHKKQSRS

SRRM4

161

A7MD48
KTALRQRHKEKKRSA

PIEZO2

1591

Q9H5I5
EVEAACEKHTRRKTR

ZNF710

86

Q8N1W2
SKSALHRRADKKKRS

ZDBF2

1716

Q9HCK1
KAERKRKAEAARLHR

UBR1

1016

Q8IWV7
LVKAEDKARVHRSKK

ZNF512B

446

Q96KM6
SRSSDRETKHKRRKR

TOPORS

846

Q9NS56
AQKRVRSRASRKHKD

SP140

566

Q13342
DRKTKKRHCVVRQLT

KDR

646

P35968
EDSSKRIRKSHKRPK

ERCC4

456

Q92889
HESDVKIVAKSIRDR

WNK2

521

Q9Y3S1
HKVNAETAKRKSIRR

ARHGAP21

1786

Q5T5U3
VKHTKRVHERAGAKR

ZNF518B

206

Q9C0D4
VKHKRIHSREKRGDS

ZNF649

446

Q9BS31
KKSRPVRHTKRHEEE

PP2D1

41

A8MPX8