Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	WD40_repeat_dom	FBXW8 WDR64 WDR75 ITFG2 WDR88 APAF1 NOL10 IFT80	8.56e-06	297	65	8	IPR017986
Domain	-	FBXW8 WDR64 WDR75 WDR88 APAF1 NOL10 IFT80 PLXNB3	1.96e-05	333	65	8	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	FBXW8 WDR64 WDR75 WDR88 APAF1 NOL10 IFT80 PLXNB3	2.04e-05	335	65	8	IPR015943
Domain	Cse1	IPO8 IPO7	3.57e-05	3	65	2	IPR013713
Domain	Cse1	IPO8 IPO7	3.57e-05	3	65	2	PF08506
Domain	WD40	FBXW8 WDR64 WDR75 WDR88 APAF1 NOL10 IFT80	3.96e-05	268	65	7	SM00320
Domain	WD40_repeat	FBXW8 WDR64 WDR75 WDR88 APAF1 NOL10 IFT80	4.35e-05	272	65	7	IPR001680
Domain	WD_REPEATS_1	FBXW8 WDR64 WDR75 WDR88 APAF1 NOL10 IFT80	5.00e-05	278	65	7	PS00678
Domain	WD_REPEATS_2	FBXW8 WDR64 WDR75 WDR88 APAF1 NOL10 IFT80	5.11e-05	279	65	7	PS50082
Domain	WD_REPEATS_REGION	FBXW8 WDR64 WDR75 WDR88 APAF1 NOL10 IFT80	5.11e-05	279	65	7	PS50294
Domain	WD40	FBXW8 WDR64 WDR75 WDR88 APAF1 IFT80	2.80e-04	259	65	6	PF00400
Domain	TPR_8	TTC21A GTF3C3 XAB2	8.32e-04	53	65	3	PF13181
Domain	Quinoprotein_ADH-like_supfam	FBXW8 WDR75 WDR88	8.32e-04	53	65	3	IPR011047
Domain	IMPORTIN_B_NT	IPO8 IPO7	1.06e-03	14	65	2	PS50166
Domain	IBN_N	IPO8 IPO7	1.22e-03	15	65	2	PF03810
Domain	IBN_N	IPO8 IPO7	1.39e-03	16	65	2	SM00913
Domain	Importin-beta_N	IPO8 IPO7	1.57e-03	17	65	2	IPR001494
Domain	ARM-like	KPNA7 NALF1 IPO8 IPO7 ULK4	2.48e-03	270	65	5	IPR011989
Domain	CARD	APAF1 NLRP1	4.25e-03	28	65	2	PF00619
Domain	CARD	APAF1 NLRP1	5.20e-03	31	65	2	IPR001315
Domain	-	CCNF TTC21A GTF3C3 XAB2	5.86e-03	207	65	4	1.25.40.10
Domain	CARD	APAF1 NLRP1	5.87e-03	33	65	2	PS50209
Domain	MFS	SLC46A3 SV2C MFSD5	6.33e-03	108	65	3	PS50850
Domain	ARM-type_fold	KPNA7 IPO8 IPO7 PIK3C2A ULK4	6.49e-03	339	65	5	IPR016024
Domain	-	KPNA7 IPO8 IPO7 ULK4	7.47e-03	222	65	4	1.25.10.10
Pubmed	Preferential utilization of Imp7/8 in nuclear import of Smads.	IPO8 IPO7	1.16e-05	3	69	2	18519565
Pubmed	A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis.	APAF1 NLRP1	2.32e-05	4	69	2	11113115
Pubmed	A novel class of RanGTP binding proteins.	IPO8 IPO7	3.86e-05	5	69	2	9214382
Pubmed	Gene frequency of human platelet alloantigens-1 to -6 and -15 in Saudi blood donors.	CD109 HPSE	5.79e-05	6	69	2	27019315
Pubmed	Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.	IPO8 IPO7	8.09e-05	7	69	2	11682607
Pubmed	Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.	APAF1 NLRP1	1.08e-04	8	69	2	17418785
Pubmed	Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.	IPO8 IPO7	1.08e-04	8	69	2	27114554
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MDN1 IPO7 WDR75 NOL10 NUP160 GTF3C3 XAB2	3.14e-04	653	69	7	22586326
Pubmed	Possible roles of Robo1+ ensheathing cells in guiding dorsal-zone olfactory sensory neurons in mouse.	ACSM4 OR5D18	4.01e-04	15	69	2	23821580
Pubmed	Inhibition of Glycolysis in Pathogenic TH17 Cells through Targeting a miR -21-Peli1-c-Rel Pathway Prevents Autoimmunity.	TRPM7 FCHO2	4.57e-04	16	69	2	32414810
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	IPO7 WDR75 NOL10 NUP160 XAB2	5.24e-04	332	69	5	25693804
Pubmed	Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.	NUP160 LRRC41	5.81e-04	18	69	2	26598607
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	MDN1 IPO8 IPO7 WDR75 PIK3C2A TRPM7 APAF1 IFT80 GTF3C3 LRRC41	6.76e-04	1487	69	10	33957083
Pubmed	Oxidized thioredoxin-1 restrains the NLRP1 inflammasome.	FBXW8 NLRP1	7.95e-04	21	69	2	36332009
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	HBS1L IPO7 WDR75 NUP160 XAB2 LRRC41	8.62e-04	560	69	6	35241646
Pubmed	A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.	NOL10 COX18	9.55e-04	23	69	2	25217961
Pubmed	Genome-wide identification of endothelial cell-enriched genes in the mouse embryo.	TMEM204 CD109	9.55e-04	23	69	2	22535667
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	NLRP1 DNMBP DOP1B	1.11e-03	102	69	3	10231032
Pubmed	The cooperative function of nuclear receptor coactivator 1 (NCOA1) and NCOA3 in placental development and embryo survival.	PDPK1 NR6A1	1.22e-03	26	69	2	20685850
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	HBS1L PDPK1 FCHO2 DNMBP GTF3C3 LRRC41	1.27e-03	604	69	6	38803224
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	HBS1L MDN1 IPO7 WDR75 PIK3C2A TAF1B NOL10 NUP160 GTF3C3	1.38e-03	1353	69	9	29467282
Pubmed	Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.	IPO8 IPO7 ZZEF1	1.50e-03	113	69	3	30352685
Pubmed	CRL4AMBRA1 is a master regulator of D-type cyclins.	FBXW8 LRRC41	1.63e-03	30	69	2	33854235
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	MDN1 IPO8 IPO7 WDR75 NUP160 GTF3C3	1.68e-03	638	69	6	33239621
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	AMPD1 WDR64 MDN1 IPO7 WDR75 LRRC41	1.68e-03	638	69	6	31182584
Pubmed	GOLPH3 and GOLPH3L are broad-spectrum COPI adaptors for sorting into intra-Golgi transport vesicles.	TPST2 B4GALT4	1.85e-03	32	69	2	34473204
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	MDN1 WDR75 CD109 GTF3C3	1.85e-03	262	69	4	36880596
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	TMEM161A IPO8 IPO7 FCHO2 ZZEF1 NUP160	1.94e-03	657	69	6	36180527
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	HBS1L MDN1 IPO8 IPO7 WDR75 NOL10 GLOD4 NUP160 GTF3C3	1.97e-03	1425	69	9	30948266
GeneFamily	Armadillo repeat containing\|Importins	KPNA7 IPO8 IPO7	1.39e-05	18	48	3	596
GeneFamily	WD repeat domain containing	FBXW8 WDR64 WDR75 WDR88 APAF1 IFT80	6.44e-05	262	48	6	362
GeneFamily	Intraflagellar transport proteins\|Tetratricopeptide repeat domain containing	TTC21A IFT80	1.84e-03	24	48	2	615
GeneFamily	WD repeat domain containing\|Caspase recruitment domain containing\|Apoptosome	APAF1 NLRP1	2.86e-03	30	48	2	959
Disease	aspartate aminotransferase measurement	HBS1L TRPM7 PDPK1 IFT80 FCHO2 DNMBP IL18RAP NUP160	8.11e-04	904	65	8	EFO_0004736
Disease	ciliopathy (implicated_via_orthology)	IFT80 MAP4K2	3.53e-03	40	65	2	DOID:0060340 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KKLLLSDSGFYLCAW	TRBV30	96	A0A0K0K1B3
LATGSSDCFLKLWDL	APAF1	716	O14727
YWLCSSFVGLSQNLL	COX18	281	Q8N8Q8
LGTSENKLCFDLLSW	ACCS	101	Q96QU6
VWRTDGLSSCSYKLV	B4GALT4	311	O60513
LNLATYWKCSASTTD	FCHO2	671	Q0JRZ9
SLADLKSLYNEWGCT	DNMBP	896	Q6XZF7
TLCGRYWLDLKSSDI	ACSM4	251	P0C7M7
TWCYELNLIAEGLKS	AMPD1	731	P23109
SQSSELTKWYKGLCL	HBS1L	456	Q9Y450
LSLSCSDTYINQWLL	OR5D18	186	Q8NGL1
SWLYCVNNVLLSLSG	MAP4K2	531	Q12851
NISGCSTKKLLWTYS	IL18RAP	21	O95256
ACWALSYLTDGSNKR	KPNA7	261	A9QM74
LLTEISSSWDGCQKY	MDN1	4181	Q9NU22
KSCLEKWLSSSNTSY	MARCHF2	91	Q9P0N8
ATDTSQYDLWGKLIC	MTMR10	56	Q9NXD2
SDLQKSLNYWCNLLG	GLOD4	161	Q9HC38
GYFWCNSTLTKVLNS	ERVFC1-1	356	P60608
TKWLAKDLFLYSCGL	DOP1B	96	Q9Y3R5
TTSCAWLGYSDDTLK	ENOSF1	191	Q7L5Y1
WLGYSDDTLKQLCAQ	ENOSF1	196	Q7L5Y1
LPDSSISDYSCWKLI	FBXW8	166	Q8N3Y1
SSWNDYLGLATLITK	NANOS1	41	Q8WY41
EKLLTNWLSICLYAF	PLXNB3	1451	Q9ULL4
YLQSDNSACWLGILL	IPO7	136	O95373
LSCSDISINVWYGLA	OR52B6	206	Q8NGF0
FLTCGTKLLYLWTSS	PIK3C2A	801	O00443
SLSQSWDRKCKDGLY	NLRP1	1431	Q9C000
LWKKSYLSESCNSSV	MDM1	16	Q8TC05
IYSLSCGKSLPEWLS	NOL10	11	Q9BSC4
LLLDYCSSKGYNISW	HPSE	206	Q9Y251
AYAILLCTWKKDTGS	ITFG2	206	Q969R8
NKSDIWSLGCILYEL	NEK3	181	P51956
CGLWVLTDANLTKDY	CD109	636	Q6YHK3
TLRLCDKTGWSYALE	IFT80	251	Q9P2H3
GYTGTLDCLLQTWKN	SLC25A30	241	Q5SVS4
QGCLTSSYLLWESDR	CCNF	216	P41002
SLSSLWLLCNSYNSV	MBOAT4	401	Q96T53
KWSYSLCISNLTLND	LY9	111	Q9HBG7
LTYCNLTSWGELMKS	GAMT	166	Q14353
WLGRKNSCVLFSLTY	MFSD5	101	Q6N075
QSSASWLGSLLCLYQ	IPO8	141	O15397
WLGSLLCLYQLVKTY	IPO8	146	O15397
LSIKDYTCLLSSTWQ	NR6A1	311	Q15406
NLWLAACLSLLYCSK	TAS2R38	106	P59533
FTDQLGKLWCSLADY	XAB2	251	Q9HCS7
CLYNGLTISAWNSLD	SV2C	641	Q496J9
LNCTLLLKTLGGYSW	TMEM161A	386	Q9NX61
SWVSLESLTLSYNGL	LRRC41	486	Q15345
KGQSLLTKNSLYWLS	TAF1B	501	Q53T94
KSSDLWALGCIIYQL	PDPK1	261	O15530
VKCTSWNEGSYELLI	SLC46A3	436	Q7Z3Q1
KSQCESLNLTGELYW	SCN5A	1381	Q14524
LSYYLIKWGSECLAT	NUP160	771	Q12769
WNLLLKAIYSLCDLS	GTF3C3	626	Q9Y5Q9
SRYCTSALWSLGLTQ	AQP11	131	Q8NBQ7
KWTATACDCLSLYLT	RNF17	1041	Q9BXT8
GFDLSSYRDCLTKWN	TPST2	201	O60704
KLLSGSYDCTVKLWD	WDR88	116	Q6ZMY6
LQLYSCSLDGTIKLW	WDR75	71	Q8IWA0
DWSLLSKKECLSYGG	SLC4A5	716	Q9BY07
EKSWLLLADIYCQGS	TTC21A	1201	Q8NDW8
SECGKAYSWKSQLLL	ZNF26	261	P17031
SVQGSLLSWCYLQLK	ZZEF1	966	O43149
LLSWCYLQLKSTDSG	ZZEF1	971	O43149
SWSCYLNIGACLLAT	TMEM204	166	Q9BSN7
SWSQLGLCAKIEFLS	TRPM7	1601	Q96QT4
FSISSDLWSLGCLLY	ULK4	196	Q96C45
QDTSWITGCDYLLQL	WDR64	161	B1ANS9
NLTLISSLGCWYGAK	ZNF776	46	Q68DI1
CNSYTLWELFSGLSS	NALF1	226	B1AL88