Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR51A4 OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 OR52J3 OR52E2 OR51F1 OR10D4P	4.91e-11	431	87	16	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR51A4 OPRPN OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 ADGRV1 OR51V1 LGR5 OR52J3 OR52E2 OR51F1 OR10D4P	6.31e-09	884	87	19	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR51A4 OPRPN OR51E1 IL13RA2 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 ADGRV1 PTPRU OR51V1 LGR5 PRLR OR52J3 OR52E2 OR51F1 OR10D4P	5.16e-08	1353	87	22	GO:0004888
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR51A4 OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 OR52J3 OR52E2 OR51F1 OR10D4P	2.18e-11	432	85	16	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR51A4 OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 OR52J3 OR52E2 OR51F1 OR10D4P	6.51e-11	465	85	16	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR51A4 OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 OR52J3 OR52E2 OR51F1 OR10D4P	1.21e-10	485	85	16	GO:0050907
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR51A4 OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 ADGRV1 OR51V1 OR52J3 OR52E2 OR51F1 OR10D4P	1.95e-10	582	85	17	GO:0050906
GeneOntologyBiologicalProcess	sensory perception	OR51A4 OPRPN OR51E1 ATP6V1B1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 TSPEAR LAMB2 OR5K3 OR52W1 ADGRV1 OR51V1 USH2A OR52J3 OR52E2 OR51F1 OR10D4P	2.48e-10	1072	85	22	GO:0007600
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR51A4 OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 OR52J3 OR52E2 OR51F1 OR10D4P	3.75e-10	524	85	16	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR51A4 OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 OR52J3 OR52E2 OR51F1 OR10D4P	7.00e-10	547	85	16	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus	OR51A4 OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 ADGRV1 OR51V1 OR52J3 OR52E2 OR51F1 OR10D4P	5.09e-09	722	85	17	GO:0051606
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR51A4 OPRPN OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 DGKH OR52W1 ADGRV1 OR51V1 LGR5 RGS3 RLN1 OR52J3 OR52E2 OR51F1 OR10D4P	3.17e-08	1395	85	22	GO:0007186
GeneOntologyBiologicalProcess	maintenance of animal organ identity	ADGRV1 USH2A	1.66e-04	5	85	2	GO:0048496
GeneOntologyCellularComponent	ciliary transition zone	TMEM67 CC2D2A ADGRV1 CPLANE1 USH2A	2.35e-05	81	88	5	GO:0035869
GeneOntologyCellularComponent	USH2 complex	ADGRV1 USH2A	1.05e-04	4	88	2	GO:1990696
GeneOntologyCellularComponent	stereocilia ankle link	ADGRV1 USH2A	2.60e-04	6	88	2	GO:0002141
GeneOntologyCellularComponent	stereocilia ankle link complex	ADGRV1 USH2A	2.60e-04	6	88	2	GO:0002142
GeneOntologyCellularComponent	stereocilium membrane	ADGRV1 USH2A	2.60e-04	6	88	2	GO:0060171
GeneOntologyCellularComponent	periciliary membrane compartment	ADGRV1 USH2A	2.60e-04	6	88	2	GO:1990075
GeneOntologyCellularComponent	stereocilia coupling link	ADGRV1 USH2A	4.83e-04	8	88	2	GO:0002139
GeneOntologyCellularComponent	MKS complex	TMEM67 CC2D2A	1.54e-03	14	88	2	GO:0036038
MousePheno	abnormal renal tubule epithelial cell primary cilium morphology	TMEM67 CC2D2A CPLANE1	2.94e-05	16	54	3	MP:0011066
MousePheno	abnormal renal tubule epithelium morphology	TMEM67 LAMB2 CC2D2A CPLANE1	3.41e-05	48	54	4	MP:0009640
MousePheno	abnormal kidney epithelium morphology	TMEM67 LAMB2 CC2D2A CPLANE1	8.82e-05	61	54	4	MP:0004967
MousePheno	abnormal kidney epithelial cell primary cilium morphology	TMEM67 CC2D2A CPLANE1	9.14e-05	23	54	3	MP:0011065
Domain	Olfact_rcpt	OR51A4 OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 OR52J3 OR52E2	1.59e-09	393	82	14	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR51A4 OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 LGR5 OR52J3 OR52E2	1.92e-07	670	82	15	IPR017452
Domain	7tm_1	OR51A4 OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 LGR5 OR52J3 OR52E2	2.20e-07	677	82	15	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR51A4 OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 LGR5 OR52J3 OR52E2	2.55e-07	685	82	15	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR51A4 OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 LGR5 OR52J3 OR52E2	2.85e-07	691	82	15	PS50262
Domain	GPCR_Rhodpsn	OR51A4 OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 LGR5 OR52J3 OR52E2	2.91e-07	692	82	15	IPR000276
Domain	FN3	COL6A3 IL13RA2 MDGA2 PTPRU USH2A PRLR	2.43e-04	199	82	6	PS50853
Domain	EPTP	TSPEAR ADGRV1	2.82e-04	6	82	2	PF03736
Domain	EPTP	TSPEAR ADGRV1	2.82e-04	6	82	2	IPR005492
Domain	FN3_dom	COL6A3 IL13RA2 MDGA2 PTPRU USH2A PRLR	3.16e-04	209	82	6	IPR003961
Domain	EAR	TSPEAR ADGRV1	3.94e-04	7	82	2	IPR009039
Domain	EAR	TSPEAR ADGRV1	3.94e-04	7	82	2	PS50912
Domain	ConA-like_dom	CLSTN3 TSPEAR MDGA2 ADGRV1 PTPRU USH2A	4.05e-04	219	82	6	IPR013320
Domain	MAM_1	MDGA2 PTPRU	2.20e-03	16	82	2	PS00740
Domain	Laminin_N	LAMB2 USH2A	2.20e-03	16	82	2	IPR008211
Domain	LAMININ_NTER	LAMB2 USH2A	2.20e-03	16	82	2	PS51117
Domain	Laminin_N	LAMB2 USH2A	2.20e-03	16	82	2	PF00055
Domain	LamNT	LAMB2 USH2A	2.20e-03	16	82	2	SM00136
Domain	MAM	MDGA2 PTPRU	2.48e-03	17	82	2	SM00137
Domain	MAM	MDGA2 PTPRU	2.78e-03	18	82	2	PF00629
Domain	MAM_dom	MDGA2 PTPRU	2.78e-03	18	82	2	IPR000998
Domain	MAM_2	MDGA2 PTPRU	2.78e-03	18	82	2	PS50060
Domain	EGF_LAM_2	LAMB2 USH2A	7.65e-03	30	82	2	PS50027
Domain	EGF_LAM_1	LAMB2 USH2A	7.65e-03	30	82	2	PS01248
Domain	-	CLSTN3 ADGRV1 USH2A	8.45e-03	95	82	3	2.60.120.200
Domain	-	COL6A3 IL13RA2 SIGLEC7 PSG9 MDGA2 PTPRU USH2A PRLR	8.57e-03	663	82	8	2.60.40.10
Domain	FN3	COL6A3 PTPRU USH2A PRLR	8.94e-03	185	82	4	SM00060
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR51A4 OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 OR52J3 OR52E2 OR51F1	1.19e-09	417	69	15	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR51A4 OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR52W1 OR51V1 OR52J3 OR52E2 OR51F1	4.58e-09	389	69	14	M14091
Pathway	REACTOME_SENSORY_PERCEPTION	OR51A4 OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 OR52J3 OR52E2 OR51F1	3.25e-07	636	69	15	M41834
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR51E1 ATP6V1B1 OR51F2 OR52D1 OR52E8 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 OR52J3 OR52E2 OR51F1 OR10D4P	2.37e-13	346	88	14	14611657
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR51E1 OR51F2 OR52D1 OR52E8 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 OR52J3 OR52E2 OR51F1 OR10D4P	3.68e-12	340	88	13	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR51E1 OR51F2 OR52D1 OR52E8 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 OR52J3 OR52E2 OR51F1 OR10D4P	3.68e-12	340	88	13	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR51E1 OR51F2 OR52D1 OR52E8 OR52N5 OR52E4 OR5K3 OR52W1 OR51V1 OR52J3 OR52E2 OR51F1 OR10D4P	4.11e-12	343	88	13	32295537
Pubmed	The human olfactory receptor gene family.	OR51E1 OR51F2 OR4S1 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR52W1 OR51V1 OR52J3 OR52E2 OR51F1 OR10D4P	9.22e-11	541	88	14	14983052
Pubmed	Characteristics of Retinitis Pigmentosa Associated with ADGRV1 and Comparison with USH2A in Patients from a Multicentric Usher Syndrome Study Treatrush.	ADGRV1 USH2A	6.33e-06	2	88	2	34638692
Pubmed	Usher's Syndrome Type II: A Comparative Study of Genetic Mutations and Vestibular System Evaluation.	ADGRV1 USH2A	6.33e-06	2	88	2	28653555
Pubmed	Disease expression in Usher syndrome caused by VLGR1 gene mutation (USH2C) and comparison with USH2A phenotype.	ADGRV1 USH2A	6.33e-06	2	88	2	15671307
Pubmed	PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome.	ADGRV1 USH2A	1.90e-05	3	88	2	20440071
Pubmed	Targeted next generation sequencing in Italian patients with Usher syndrome: phenotype-genotype correlations.	ADGRV1 USH2A	1.90e-05	3	88	2	29142287
Pubmed	The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1.	ADGRV1 USH2A	1.90e-05	3	88	2	16434480
Pubmed	Mutations in 3 genes (MKS3, CC2D2A and RPGRIP1L) cause COACH syndrome (Joubert syndrome with congenital hepatic fibrosis).	TMEM67 CC2D2A	1.90e-05	3	88	2	19574260
Pubmed	Non-USH2A mutations in USH2 patients.	ADGRV1 USH2A	1.90e-05	3	88	2	22147658
Pubmed	Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina.	ADGRV1 USH2A	3.79e-05	4	88	2	37127773
Pubmed	Individual USH2 proteins make distinct contributions to the ankle link complex during development of the mouse cochlear stereociliary bundle.	ADGRV1 USH2A	3.79e-05	4	88	2	26401052
Pubmed	Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism.	ADGRV1 USH2A	3.79e-05	4	88	2	18463160
Pubmed	Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss.	ADGRV1 USH2A	3.79e-05	4	88	2	20502675
Pubmed	Deafness-Associated ADGRV1 Mutation Impairs USH2A Stability through Improper Phosphorylation of WHRN and WDSUB1 Recruitment.	ADGRV1 USH2A	3.79e-05	4	88	2	37066759
Pubmed	Pro- and anti-apoptotic dual functions of the C5a receptor: involvement of regulator of G protein signaling 3 and extracellular signal-regulated kinase.	OPRPN RGS3	3.79e-05	4	88	2	19333232
Pubmed	Usher Syndrome Type II	ADGRV1 USH2A	3.79e-05	4	88	2	20301515
Pubmed	Localization of PDZD7 to the stereocilia ankle-link associates this scaffolding protein with the Usher syndrome protein network.	ADGRV1 USH2A	3.79e-05	4	88	2	23055499
Pubmed	Whirlin and PDZ domain-containing 7 (PDZD7) proteins are both required to form the quaternary protein complex associated with Usher syndrome type 2.	ADGRV1 USH2A	3.79e-05	4	88	2	25406310
Pubmed	A novel Usher protein network at the periciliary reloading point between molecular transport machineries in vertebrate photoreceptor cells.	ADGRV1 USH2A	6.30e-05	5	88	2	17906286
Pubmed	Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor.	CSN2 PRLR	6.30e-05	5	88	2	15618286
Pubmed	Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice.	ADGRV1 USH2A	6.30e-05	5	88	2	24334608
Pubmed	Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2.	ADGRV1 USH2A	6.30e-05	5	88	2	16301216
Pubmed	Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer cells in undifferentiated and proliferative state.	E2F3 LGR5	6.30e-05	5	88	2	36276637
Pubmed	Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala.	RELN PTPRU PRLR MPPED1	7.59e-05	88	88	4	21491433
Pubmed	Joubert Syndrome	TMEM67 CC2D2A CPLANE1	8.85e-05	34	88	3	20301500
Pubmed	A common protein interaction domain links two recently identified epilepsy genes.	TSPEAR ADGRV1	9.43e-05	6	88	2	12095917
Pubmed	The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders.	TSPEAR ADGRV1	9.43e-05	6	88	2	12217514
Pubmed	Biochemical characterization of native Usher protein complexes from a vesicular subfraction of tracheal epithelial cells.	ADGRV1 USH2A	1.32e-04	7	88	2	20058854
Pubmed	Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation.	E2F3 LGR5	1.32e-04	7	88	2	31130414
Pubmed	Whirlin replacement restores the formation of the USH2 protein complex in whirlin knockout photoreceptors.	ADGRV1 USH2A	1.32e-04	7	88	2	21212183
Pubmed	Expression analysis of an evolutionarily conserved metallophosphodiesterase gene, Mpped1, in the normal and beta-catenin-deficient malformed dorsal telencephalon.	RELN MPPED1	1.32e-04	7	88	2	20503375
Pubmed	Microarray-based mutation analysis of 183 Spanish families with Usher syndrome.	ADGRV1 USH2A	1.75e-04	8	88	2	19683999
Pubmed	Activating transcription factor 5 is required for mouse olfactory bulb development via interneuron.	RELN ATF5	1.75e-04	8	88	2	25704077
Pubmed	Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions.	RELN E2F3	2.25e-04	9	88	2	17452454
Pubmed	Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle.	OPRPN NDST2	2.25e-04	9	88	2	15905575
Pubmed	Massively parallel DNA sequencing facilitates diagnosis of patients with Usher syndrome type 1.	ADGRV1 USH2A	2.81e-04	10	88	2	24618850
Pubmed	Usher protein functions in hair cells and photoreceptors.	ADGRV1 USH2A	2.81e-04	10	88	2	24239741
Pubmed	Congenital Hepatic Fibrosis Overview ─ RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	TMEM67 CC2D2A CPLANE1	3.16e-04	52	88	3	20301743
Pubmed	The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut.	LAMB2 LGR5	4.85e-04	13	88	2	36350252
Pubmed	The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3.	CSN2 PRLR	5.65e-04	14	88	2	22588720
Pubmed	Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters.	OR52D1 OR51V1	6.51e-04	15	88	2	11121057
Pubmed	Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.	ADGRV1 USH2A	7.42e-04	16	88	2	17567809
Pubmed	Heterochromatin-mediated gene silencing facilitates the diversification of olfactory neurons.	ATF5 OR5K3	7.42e-04	16	88	2	25437545
Pubmed	Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.	ACACA PI4KA ATP2A2	8.23e-04	72	88	3	36376293
Pubmed	Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data.	NDC1 NOC2L TMLHE FLAD1 GFM1 NARS2	8.75e-04	438	88	6	32628020
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR51F2 OR52J3 OR10D4P	8.91e-04	74	88	3	15081110
Pubmed	Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.	TMEM67 CC2D2A	9.43e-04	18	88	2	21068128
Pubmed	Ciliary Hedgehog signaling regulates cell survival to build the facial midline.	TMEM67 CC2D2A	1.05e-03	19	88	2	34672258
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZSWIM8 TMEM131 CIC	1.42e-03	87	88	3	12465718
Pubmed	Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets.	RELN PTPRU	1.55e-03	23	88	2	20089898
Pubmed	The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy.	E2F3 ATP2A2	1.55e-03	23	88	2	22403008
Pubmed	Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment.	RELN RLN1	1.55e-03	23	88	2	21111240
Pubmed	USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.	ACACA NOC2L ATP2A2	1.57e-03	90	88	3	35654790
Pubmed	Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors.	SLC6A1 RELN	1.83e-03	25	88	2	31665922
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	TMEM67 CC2D2A CPLANE1	2.12e-03	100	88	3	25807483
Pubmed	Genetic link between renal birth defects and congenital heart disease.	TMEM67 CC2D2A	2.29e-03	28	88	2	27002738
Interaction	ST8SIA4 interactions	TMEM67 CLSTN3 B4GALNT1 NDST2 ADGRV1 PTPRU	8.19e-07	84	77	6	int:ST8SIA4
Interaction	GPIHBP1 interactions	CLSTN3 MYO19 LAMB2 TMEM131 ADGRV1 PTPRU	1.19e-05	133	77	6	int:GPIHBP1
Cytoband	11p15.4	OR51A4 OR51E1 OR51F2 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR52W1 OR51V1 OR52J3 OR52E2 OR51F1	1.24e-16	200	88	13	11p15.4
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR51A4 OR51E1 OR51F2 OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR52W1 OR51V1 PLEKHA7 OR52J3 OR52E2 OR51F1	4.25e-12	564	88	14	chr11p15
GeneFamily	Olfactory receptors, family 52	OR52D1 OR52E8 OR52E6 OR52N5 OR52E4 OR52W1 OR52J3 OR52E2	4.84e-12	49	62	8	165
GeneFamily	Olfactory receptors, family 51	OR51A4 OR51E1 OR51F2 OR51V1 OR51F1	3.94e-07	44	62	5	164
GeneFamily	Fibronectin type III domain containing\|USH2 complex	ADGRV1 USH2A	6.91e-05	4	62	2	1244
Disease	Ciliopathies	TMEM67 CC2D2A ADGRV1 CPLANE1 USH2A	1.05e-05	110	77	5	C4277690
Disease	Familial aplasia of the vermis	TMEM67 CC2D2A CPLANE1	1.89e-05	20	77	3	cv:C0431399
Disease	COACH syndrome	TMEM67 CC2D2A	2.01e-05	3	77	2	cv:C1857662
Disease	Hepatic Fibrosis, Congenital	TMEM67 CC2D2A	2.01e-05	3	77	2	C0009714
Disease	COACH syndrome	TMEM67 CC2D2A	4.02e-05	4	77	2	C1857662
Disease	Meckel syndrome (implicated_via_orthology)	TMEM67 CC2D2A	1.86e-04	8	77	2	DOID:0050778 (implicated_via_orthology)
Disease	Disorder of eye	TMEM67 CC2D2A ADGRV1 CPLANE1 USH2A	2.37e-04	212	77	5	C0015397
Disease	Meckel-Gruber syndrome	TMEM67 CC2D2A	2.98e-04	10	77	2	cv:C0265215
Disease	myocardial infarction	COL6A3 VEPH1 NDST2 OR52E4 LAMB2 ATP2A2	3.12e-04	350	77	6	EFO_0000612
Disease	Meckel-Gruber syndrome	TMEM67 CC2D2A	6.90e-04	15	77	2	C0265215
Disease	acute graft vs. host disease, donor genotype effect measurement	MDGA2 TMEM131	6.90e-04	15	77	2	EFO_0004599, EFO_0007892
Disease	Meckel syndrome type 1	TMEM67 CC2D2A	1.00e-03	18	77	2	C3714506
Disease	temporal lobe epilepsy (is_marker_for)	SLC6A1 RELN	1.24e-03	20	77	2	DOID:3328 (is_marker_for)
Disease	Nonsyndromic Deafness	TSPEAR ADGRV1 NARS2	1.26e-03	81	77	3	C3711374
Disease	Joubert syndrome 1	TMEM67 CPLANE1	1.37e-03	21	77	2	C4551568
Disease	Autism Spectrum Disorders	RELN USH2A CIC	1.45e-03	85	77	3	C1510586
Disease	hearing impairment	ATP6V1B1 ADGRV1 USH2A	2.17e-03	98	77	3	C1384666
Disease	Colorectal Carcinoma	CLSTN3 ZZZ3 SIGLEC7 ACACA TSPEAR PTPRU LGR5	2.38e-03	702	77	7	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
GYVVVLQPDAPQILL	CLSTN3	631	Q9BQT9
LLIAPANSPLQYPLQ	B4GALNT1	136	Q00973
SLIYPALQPLDVDLP	AADAC	216	P22760
TAYEVPPPLNVLQVP	ADGRV1	3926	Q8WXG9
LLQEIVNIYPSINPP	CNOT9	66	Q92600
QPVLVYIPPQAELRG	ACACA	2076	Q13085
LGILQVPAAYVPIEP	AASDH	76	Q4L235
IPPNPQDLRLLSYIT	CFAP157	471	Q5JU67
VPQRIPQPLLPAYIL	CECR9	71	P0C854
PQPPVLDTLDLLAIY	ATF5	151	Q9Y2D1
LPQIQLYGPTNVAPI	CPNE6	401	O95741
QLQNIVKPLPPVYLT	IL13RA2	231	Q14627
LNYVLVRVQPPQPGL	REC8	46	O95072
PNYIILAPLNPGSQL	RGS3	466	P49796
PYLLLPEAAPAQAQA	PCDHB2	671	Q9Y5E7
ANLYVLVPPVLNPIL	OR52D1	281	Q9H346
LLANLYVVVPPMLNP	OR52E2	276	Q8NGJ4
LLANLYVVVPPALNP	OR52E4	276	Q8NGH9
KQIASPIYLPPILAA	C22orf23	76	Q9BZE7
GPVIVIYLQPNPSAL	OR10D4P	251	Q8NGN7
GILAVPPQLLADPLY	DOK2	316	O60496
LLSNIYLLLPPALNP	OR52W1	281	Q6IF63
TLVALNPFKPVPQLY	MYO19	71	Q96H55
SPLPVILANIYLLVP	OR51E1	271	Q8TCB6
ILANIYLLVPPVLNP	OR51E1	276	Q8TCB6
ANVYLLLPPVLNPII	OR51F1	286	A6NGY5
ANVFLLIPPVLNPII	OR51F2	291	Q8NH61
GNIYILFPPLMNPII	OR51V1	286	Q9H2C8
FLANLYVVVPPTLNP	OR52E6	276	Q96RD3
LFNIVMPPLLNPLIY	OR4S1	271	Q8NGB4
LLRVLPAVYEKQPQP	VEPH1	181	Q14D04
LVPYLNRCLQVLFPP	COG8	506	Q96MW5
PPDAILFYIPQIVQA	PI4KA	1646	P42356
IPIPDPYSSRIQNLL	LAMB2	226	P55268
DLLNPYLLQPRPALV	KCNRG	96	Q8N5I3
PVAIFYTLVIPLLNP	OR5K3	271	A6NET4
LLLVPPLTNPIVYCV	OR51A4	281	Q8NGJ6
YIPLPSLQGIAVLNI	DGKH	836	Q86XP1
TVNYQPVNPPIVIDL	MPPED1	306	O15442
EALQPLVYPLAQVII	NOC2L	426	Q9Y3T9
VPSFQLILYPNLKVP	DPRX	126	A6NFQ7
IPPELGNLPSLNYLV	LRRC58	181	Q96CX6
LVQLIVQYPPAVEPA	MDGA2	531	Q7Z553
PQTTNILFINVPLPY	RELN	1901	P78509
PPQLLRAGPTYLIIQ	PTPRU	291	Q92729
PFNLDDPYPLLVVNI	PANK3	176	Q9H999
LPPPYNLREAQVTIL	PRSS41	196	Q7RTY9
VPVQPVLLRYPNKLD	LPCAT2	241	Q7L5N7
ILYVEPLPLIFQITP	ATP2A2	946	P16615
NLSPVIRLQPLLPYS	CCDC71	451	Q8IV32
TRYLKPLNPPQELLN	CC2D2A	1301	Q9P2K1
PFVNLLPPLLQEDYL	E2F3	421	O00716
EPLTAPQLLVPDVYL	CPLANE1	2566	Q9H799
PALPQQLIQPLTTYV	COL6A3	806	P12111
FLPQNILPLAQPAVV	CSN2	76	P05814
QRKLPDVPNPLQILY	FLAD1	421	Q8NFF5
VQPLLDAVLEYLPNP	GFM1	306	Q96RP9
LVVVPLPACLNPLLY	LGR5	806	O75473
VANLYLLLPPTLNPI	OR52N5	286	Q8NH56
PPLFEIYQVLLSPTQ	NUP88	106	Q99567
PNTINGNIYPPLITI	TMEM67	476	Q5HYA8
LANLYVVVPPALNPV	OR52E8	281	Q6IFG1
LVANLYLIIPPSLNP	OR52J3	276	Q8NH60
PGILIPEIPVEYNVL	USH2A	3796	O75445
QIYPPINVLPSLSRL	ATP6V1B1	381	P15313
LAYPEAVTQLPISPL	SLC6A1	366	P30531
QPSLPELQQYVPALK	RLN1	106	P04808
NIPVFVINYPLTLKP	NARS2	361	Q96I59
LPKLPIPYITINNLN	PSG9	236	Q00887
LPVPHPILIRKYQAN	HID1	736	Q8IV36
PLEVRLFPQLQTYVP	PLEKHA7	876	Q6IQ23
YPSQPSNPLVLELQV	SIGLEC7	296	Q9Y286
LAIYLPISNPEPQIN	OPRPN	131	Q99935
QYILPTLPQQLQVAP	CIC	826	Q96RK0
LPPIVLRSQVYSLVP	STK19	166	P49842
PLIAPAYAQLQPHQL	PHC2	321	Q8IXK0
LQYLPPGVIALVNFL	TMC8	336	Q8IU68
VINVAQPLFYPQPLV	ZNF826P	41	Q6ZT77
YLQPGALLEQPVSIP	TEP1	1111	Q99973
QPLQGPVQLAVPIYS	RREB1	1006	Q92766
PADVPVYVQFIPLAL	TMEM131	856	Q92545
VTYIVQPDPPLELAV	PRLR	121	P16471
RLQTLPPVPLAQKYF	NDST2	556	P52849
VYPPVPEQLQLRIAF	ZSWIM8	96	A7E2V4
PNLPPKRNEYLLTVV	TSPEAR	96	Q8WU66
LLEVLRYPAPPNVTI	VSIG10L2	591	P0DP72
QELPVPCPNLYIQLN	UHRF1BP1	521	Q6BDS2
VIYPALPQPNFKSLL	TMLHE	21	Q9NVH6
IGLPYPQRVVQLPEI	ZZZ3	551	Q8IYH5
QSLQDLVLPTPPYLF	ZFYVE9	1041	O95405
SNPPPIIKYLALQDL	NDC1	321	Q9BTX1