Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	Rab-protein geranylgeranyltransferase complex	CHM CHML	1.19e-04	4	94	2	GO:0005968
GeneOntologyCellularComponent	ATPase complex	ACTR8 ATP6V0A1 ACTR5 ARID2 SMARCA1	2.93e-04	129	94	5	GO:1904949
Domain	ARM-type_fold	AP1B1 XPO5 ARID2 UBR4 MROH7 BTAF1 WDFY3 ARMH3 TRIP12 AP3D1 EIF3M	8.68e-07	339	92	11	IPR016024
Domain	Rab_escort	CHM CHML	2.40e-05	2	92	2	IPR001738
Domain	ARM-like	AP1B1 XPO5 ARID2 MROH7 BTAF1 WDFY3 TRIP12 AP3D1	5.61e-05	270	92	8	IPR011989
Domain	DUF2075	SLFN13 SLFN11	7.18e-05	3	92	2	IPR018647
Domain	DUF2075	SLFN13 SLFN11	7.18e-05	3	92	2	PF09848
Domain	-	AP1B1 XPO5 MROH7 BTAF1 WDFY3 TRIP12 AP3D1	1.13e-04	222	92	7	1.25.10.10
Domain	GDI	CHM CHML	1.43e-04	4	92	2	PF00996
Domain	GDP_dissociation_inhibitor	CHM CHML	1.43e-04	4	92	2	IPR018203
Domain	Cullin_CS	CUL4B CUL4A	4.96e-04	7	92	2	IPR016157
Domain	AlbA_2	SLFN13 SLFN11	4.96e-04	7	92	2	PF04326
Domain	Schlafen	SLFN13 SLFN11	4.96e-04	7	92	2	IPR029684
Domain	Schlafen_AAA_dom	SLFN13 SLFN11	4.96e-04	7	92	2	IPR007421
Domain	CULLIN	CUL4B CUL4A	4.96e-04	7	92	2	SM00182
Domain	SNF2_N	ERCC6L SMARCA1 BTAF1	5.17e-04	32	92	3	IPR000330
Domain	SNF2_N	ERCC6L SMARCA1 BTAF1	5.17e-04	32	92	3	PF00176
Domain	Cullin_Nedd8	CUL4B CUL4A	6.59e-04	8	92	2	PF10557
Domain	Cullin_Nedd8	CUL4B CUL4A	6.59e-04	8	92	2	SM00884
Domain	Cullin_neddylation_domain	CUL4B CUL4A	6.59e-04	8	92	2	IPR019559
Domain	Cullin_homology	CUL4B CUL4A	8.45e-04	9	92	2	IPR016158
Domain	Cullin	CUL4B CUL4A	1.05e-03	10	92	2	PF00888
Domain	CULLIN_2	CUL4B CUL4A	1.05e-03	10	92	2	PS50069
Domain	Cullin_N	CUL4B CUL4A	1.05e-03	10	92	2	IPR001373
Domain	CULLIN_1	CUL4B CUL4A	1.05e-03	10	92	2	PS01256
Domain	Cullin_repeat-like_dom	CUL4B CUL4A	1.53e-03	12	92	2	IPR016159
Domain	Clathrin/coatomer_adapt-like_N	AP1B1 AP3D1	2.42e-03	15	92	2	IPR002553
Domain	Adaptin_N	AP1B1 AP3D1	2.42e-03	15	92	2	PF01602
Domain	PINT	GPS1 EIF3M	2.75e-03	16	92	2	SM00088
Domain	PCI_dom	GPS1 EIF3M	3.11e-03	17	92	2	IPR000717
Domain	PCI	GPS1 EIF3M	3.11e-03	17	92	2	PF01399
Domain	EF_HAND_1	EFHD1 EFHD2 PLCD4 TNNC2 AIF1L	3.38e-03	204	92	5	PS00018
Domain	-	CFAP54 ERCC6L ST7 GPS1 CABIN1	3.59e-03	207	92	5	1.25.40.10
Domain	-	CUL4B CUL4A ARID2 GPS1 EIF3M	4.47e-03	218	92	5	1.10.10.10
Domain	HEAT_REPEAT	MROH7 BTAF1 AP3D1	4.99e-03	70	92	3	PS50077
Domain	EF_HAND_2	EFHD1 EFHD2 PLCD4 TNNC2 AIF1L	5.70e-03	231	92	5	PS50222
Domain	EF_hand_dom	EFHD1 EFHD2 PLCD4 TNNC2 AIF1L	5.80e-03	232	92	5	IPR002048
Domain	TPR-like_helical_dom	CFAP54 ERCC6L ST7 GPS1 CABIN1	5.91e-03	233	92	5	IPR011990
Domain	WHTH_DNA-bd_dom	CUL4B CUL4A ARID2 GPS1 EIF3M	6.91e-03	242	92	5	IPR011991
Domain	EFh	EFHD1 EFHD2 PLCD4 TNNC2	7.74e-03	158	92	4	SM00054
Domain	EF-hand_7	EFHD1 EFHD2 TNNC2	8.54e-03	85	92	3	PF13499
Domain	-	EFHD1 EFHD2 PLCD4 TNNC2 AIF1L	9.41e-03	261	92	5	1.10.238.10
Pathway	REACTOME_DNA_DAMAGE_RECOGNITION_IN_GG_NER	CUL4B CUL4A ACTR8 ACTR5 GPS1	1.24e-06	38	71	5	M27592
Pathway	REACTOME_DNA_DAMAGE_RECOGNITION_IN_GG_NER	CUL4B CUL4A ACTR8 ACTR5 GPS1	1.24e-06	38	71	5	MM15301
Pathway	REACTOME_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR_GG_NER	CUL4B CUL4A ACTR8 ACTR5 GPS1	6.01e-05	83	71	5	MM15305
Pathway	REACTOME_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR_GG_NER	CUL4B CUL4A ACTR8 ACTR5 GPS1	6.37e-05	84	71	5	M27594
Pathway	REACTOME_NUCLEOTIDE_EXCISION_REPAIR	CUL4B CUL4A ACTR8 ACTR5 GPS1	2.09e-04	108	71	5	M7927
Pathway	REACTOME_NUCLEOTIDE_EXCISION_REPAIR	CUL4B CUL4A ACTR8 ACTR5 GPS1	2.09e-04	108	71	5	MM15304
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	ATP6V0A1 KIDINS220 AP1B1 ERCC6L XPO5 NSF UBR4 GPS1 UGGT2 BTAF1 SEC63 QARS1 TRIP12 VPS53 RRP1	4.07e-08	942	95	15	31073040
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	CUL4B EEF2 AP1B1 GPS1 SMARCA1 CCT7 SEC63 QARS1 DHTKD1 VPS53 PGM1	4.54e-08	451	95	11	36168627
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CUL4B EEF2 AP1B1 ERCC6L XPO5 NSF UBR4 GPS1 CCT7 QARS1 MAP2K7 AP3D1	1.79e-07	638	95	12	33239621
Pubmed	Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.	CUL4A WBP11 RPLP0 KCTD10 SMARCA1 BTAF1 IFI16 AP3D1 EIF3M	3.13e-07	329	95	9	34316702
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	EEF2 WDR36 XPO5 NSF ST7 UBR4 CCT7 EXOC1 BTAF1 SEC63 CABIN1 QARS1 IFI16 VPS53 AP3D1 EIF3M RRP1	3.38e-07	1440	95	17	30833792
Pubmed	Small molecule NSC1892 targets the CUL4A/4B-DDB1 interactions and causes impairment of CRL4DCAF4 E3 ligases to inhibit colorectal cancer cell growth.	CUL4B CUL4A ST7	6.86e-07	7	95	3	32140073
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SNRNP27 CWF19L2 WBP11 EEF2 KIDINS220 RPLP0 ZBED4 ARID2 KCTD10 PIN4 SEC63 TRIP12 AP3D1 RRP1	1.44e-06	1082	95	14	38697112
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CUL4B CUL4A ACTR8 ACTR5 POLR1E ABCA12 ARID2 SCN5A SMARCA1 SLFN11 WDFY3 RAB11FIP1 MAP2K7 VPS53	2.06e-06	1116	95	14	31753913
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	MYT1L WBP11 EEF2 ACTR8 ATP6V0A1 TRIM9 UBR4 CHMP3 CCT7 EXOC1 WDFY3 CABIN1 QARS1 TRIP12 MGAT5B	2.08e-06	1285	95	15	35914814
Pubmed	Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.	CUL4B CUL4A ATP6V0A1 UBR4 GPS1	2.63e-06	79	95	5	27325702
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	CUL4B CUL4A WBP11 XPO5 NSF TBC1D1 GPS1 UGGT2 EXOC1 PRKG2 RAB11FIP1 NME7 QARS1 VPS53 EIF3M	2.91e-06	1321	95	15	27173435
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	CUL4B CUL4A SNRNP27 WDR36 NSF POLR1E KCTD10 GPS1 CHMP3 UGGT2 CCT7 TRIP12 EIF3M	3.54e-06	1005	95	13	19615732
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	WBP11 EEF2 WDR36 AP1B1 NSF UBR4 GPS1 EFHD2 CCT7 EXOC1 NME7 QARS1 EIF3M PGM1 RRP1	4.41e-06	1367	95	15	32687490
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	CUL4B EEF2 RPLP0 AP1B1 XPO5 NSF RPLP0P6 GPS1 EFHD2 CCT7 TRIP12 EIF3M	4.99e-06	878	95	12	37223481
Pubmed	L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.	CUL4B CUL4A GPS1	5.54e-06	13	95	3	16861906
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	CUL4B EEF2 RPLP0 UBR4 SMARCA1 EFHD2 IFI16 TRIP12 AP3D1 RRP1	5.97e-06	601	95	10	33658012
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	CUL4B CUL4A XPO5 ST7 NME7 EIF3M	7.32e-06	169	95	6	31462741
Pubmed	MYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention.	MYT1L SCN5A	7.38e-06	2	95	2	36782060
Pubmed	Fraternal twins: Swiprosin-1/EFhd2 and Swiprosin-2/EFhd1, two homologous EF-hand containing calcium binding adaptor proteins with distinct functions.	EFHD1 EFHD2	7.38e-06	2	95	2	21244694
Pubmed	Mouse choroideremia gene mutation causes photoreceptor cell degeneration and is not transmitted through the female germline.	CHM CHML	7.38e-06	2	95	2	9175730
Pubmed	Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks.	CUL4B CUL4A	7.38e-06	2	95	2	20064923
Pubmed	Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer.	CUL4B CUL4A	7.38e-06	2	95	2	27974468
Pubmed	Cloning and characterization of the human choroideremia gene.	CHM CHML	7.38e-06	2	95	2	7981670
Pubmed	The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment.	ACTR8 ACTR5	7.38e-06	2	95	2	18163988
Pubmed	Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.	SLFN13 SLFN11	7.38e-06	2	95	2	37833372
Pubmed	Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.	SLFN13 SLFN11	7.38e-06	2	95	2	29563550
Pubmed	DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.	CUL4B CUL4A WDR36 SMARCA1 WDFY3	7.98e-06	99	95	5	34161765
Pubmed	CAND1 enhances deneddylation of CUL1 by COP9 signalosome.	CUL4B CUL4A GPS1	1.08e-05	16	95	3	16036220
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	WBP11 ATP6V0A1 KIDINS220 WDR36 RPLP0 NSF ST7 UBR4 VPS13A UGGT2 RAB11FIP1 SEC63 NME7 AP3D1 RRP1	1.20e-05	1487	95	15	33957083
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	CUL4B SNRNP27 UBR4 MIPEP VPS13A CCT7 BTAF1 DHTKD1 VPS53	1.21e-05	515	95	9	31617661
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	CUL4B WBP11 EEF2 AP1B1 XPO5 NSF GPS1 BTAF1 SEC63 EIF3M	1.23e-05	653	95	10	33742100
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	CUL4A EEF2 WDR36 RPLP0 XPO5 NSF POLR1E UBR4 SEC63 QARS1 TRIP12 AP3D1 EIF3M RRP1	1.37e-05	1318	95	14	30463901
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	EEF2 RPLP0 AP1B1 XPO5 NSF UBR4 EFHD2 CCT7 SLFN11 AIF1L QARS1 AP3D1 PGM1	1.48e-05	1149	95	13	35446349
Pubmed	Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR.	EEF2 WDR36 RPLP0 EFHD1 EFHD2 TNNC2 AIF1L	1.51e-05	289	95	7	37132043
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	EEF2 WDR36 POLR1E UBR4 SMARCA1 CCT7 EXOC1 WDFY3 NME7 QARS1 IFI16 TRIP12 AP3D1 EIF3M	1.83e-05	1353	95	14	29467282
Pubmed	Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4DCAF5 ubiquitin ligase.	CUL4B CUL4A GPS1	1.85e-05	19	95	3	30442713
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	SNRNP27 WBP11 ACTR8 RPLP0 ACTR5 UBR4 CCT7	1.91e-05	300	95	7	28561026
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	CUL4B CUL4A WBP11 EEF2 WDR36 XPO5 POLR1E UBR4 EFHD2 CCT7 IFI16 EIF3M	2.09e-05	1014	95	12	32416067
Pubmed	An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases.	CUL4B CUL4A KCTD10 GPS1	2.12e-05	59	95	4	19295130
Pubmed	CRL4DCAF1/VprBP E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development.	CUL4B CUL4A GPS1	2.18e-05	20	95	3	33355139
Pubmed	CUL4high Lung Adenocarcinomas Are Dependent on the CUL4-p21 Ubiquitin Signaling for Proliferation and Survival.	CUL4B CUL4A	2.21e-05	3	95	2	34119472
Pubmed	CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma.	CUL4B CUL4A	2.21e-05	3	95	2	32587774
Pubmed	TBC1D1 interacting proteins, VPS13A and VPS13C, regulate GLUT4 homeostasis in C2C12 myotubes.	TBC1D1 VPS13A	2.21e-05	3	95	2	33087848
Pubmed	Cullin4B/E3-ubiquitin ligase negatively regulates beta-catenin.	CUL4B CUL4A	2.21e-05	3	95	2	17954973
Pubmed	E3 ubiquitin ligase Cullin4B mediated polyubiquitination of p53 for its degradation.	CUL4B CUL4A	2.21e-05	3	95	2	24452595
Pubmed	Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA.	SLFN13 SLFN11	2.21e-05	3	95	2	38875319
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	EEF2 KIDINS220 RPLP0 ERCC6L XPO5 NSF CCT7 SEC63 QARS1 AP3D1	2.45e-05	708	95	10	39231216
Pubmed	Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.	CUL4A EEF2 GPS1	2.53e-05	21	95	3	11337588
Pubmed	UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.	CUL4B CUL4A UBR4 KBTBD2	2.58e-05	62	95	4	18775313
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	CUL4B CUL4A NSF NME7 TRIP12 EIF3M	2.64e-05	212	95	6	33462405
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	ZBED4 XPO5 GPS1 SLFN11 IFI16	2.88e-05	129	95	5	23022380
Pubmed	Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.	CUL4B AP1B1 NSF UBR4 SLFN11 AP3D1 EIF3M	3.07e-05	323	95	7	24797263
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	AP1B1 ERCC6L XPO5 NSF CCT7 EXOC1 BTAF1 TRIP12 MAP2K7	3.17e-05	582	95	9	20467437
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	EEF2 ATP6V0A1 KIDINS220 WDR36 RPLP0 XPO5 NSF UBR4 SMARCA1 CCT7 SEC63 QARS1 EIF3M RRP1	3.23e-05	1425	95	14	30948266
Pubmed	Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway.	CUL4B CUL4A GPS1	3.36e-05	23	95	3	22038470
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	EEF2 ATP6V0A1 KIDINS220 RPLP0 GUCY1A2 AP1B1 NSF TRIM9 KCTD10 EFHD2 CCT7 EXOC1 AP3D1 PGM1	3.39e-05	1431	95	14	37142655
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	ZBED4 TRIM9 CEP95 UBR4 VPS13A PKHD1 CHML TRIP12 PGM1 RBM41	3.40e-05	736	95	10	29676528
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	CUL4A SNRNP27 WDR36 SMARCA1 IFI16 TRIP12 RRP1	3.65e-05	332	95	7	25693804
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	WBP11 EEF2 RPLP0 GUCY1A2 ZBED4 FAM186A UBR4 GPS1 VPS13A SMARCA1 PKHD1 UGGT2 TRIP12 AP3D1	3.68e-05	1442	95	14	35575683
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	MYT1L CUL4B XPO5 TRIM9 TBC1D1 WDFY3	3.69e-05	225	95	6	12168954
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	EEF2 WDR36 RPLP0 POLR1E KCTD10 SMARCA1 CCT7 SEC63 QARS1 IFI16 TRIP12 EIF3M RRP1	3.77e-05	1257	95	13	36526897
Pubmed	Tagging genes with cassette-exchange sites.	XPO5 NSF KCTD10 UBR4 EXOC1 CHM TRIP12	3.86e-05	335	95	7	15741177
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	XPO5 TTLL6 NSF POLR1E SCMH1 EFHD2 CCT7 RAB11FIP1 SEC63 EIF3M	4.16e-05	754	95	10	35906200
Pubmed	Inflammation-dependent downregulation of miR-194-5p contributes to human intervertebral disc degeneration by targeting CUL4A and CUL4B.	CUL4B CUL4A	4.41e-05	4	95	2	30945295
Pubmed	Proximity Labeling, Quantitative Proteomics, and Biochemical Studies Revealed the Molecular Mechanism for the Inhibitory Effect of Indisulam on the Proliferation of Gastric Cancer Cells.	CUL4B CUL4A	4.41e-05	4	95	2	34420308
Pubmed	CRL4s: the CUL4-RING E3 ubiquitin ligases.	CUL4B CUL4A	4.41e-05	4	95	2	19818632
Pubmed	The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis.	AP1B1 CABIN1	4.41e-05	4	95	2	10931822
Pubmed	Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.	CUL4B CUL4A	4.41e-05	4	95	2	22453236
Pubmed	Cullin 4B is recruited to tristetraprolin-containing messenger ribonucleoproteins and regulates TNF-α mRNA polysome loading.	CUL4B CUL4A	4.41e-05	4	95	2	22262661
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	POLR1E SCMH1 ARID2 PIN4 SMARCA1 BTAF1 CABIN1 TRIP12 RRP1	4.45e-05	608	95	9	36089195
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	EEF2 KIDINS220 RPLP0 XPO5 UBR4 UGGT2 CCT7 RAB11FIP1 SEC63 QARS1 TRIP12 AP3D1 EIF3M	5.19e-05	1297	95	13	33545068
Pubmed	Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.	ANO9 GUCY1A2 KCNJ4	5.51e-05	27	95	3	24550280
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	KIDINS220 WDR36 ACTR5 NSF POLR1E EFHD1 ARID2 EFHD2 CCT7 AIF1L RAB11FIP1 SEC63 EIF3M RRP1	5.51e-05	1497	95	14	31527615
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	CUL4A EEF2 WDR36 RPLP0 RPLP0P6 KCTD10 EFHD2 CCT7 IFI16 AP3D1 RRP1	5.71e-05	949	95	11	36574265
Pubmed	Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.	CUL4B UBR4 TRIP12	6.16e-05	28	95	3	35474067
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	TCF7 AP1B1 ERCC6L POLR1E ARID2 UBR4 VPS13A SLFN11 WDFY3	6.43e-05	638	95	9	31182584
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	CUL4B CUL4A XPO5 SMARCA1 SLFN11 TRIP12	6.62e-05	250	95	6	33536335
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	CUL4B EEF2 WDR36 RPLP0 AP1B1 XPO5 CCT7 QARS1 AP3D1	6.67e-05	641	95	9	36057605
Pubmed	Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting.	EEF2 RPLP0 CCT7 TNNC2 ARMH3	6.91e-05	155	95	5	22673621
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	CUL4B CUL4A EEF2 RPLP0 AP1B1 RPLP0P6 GPS1 SMARCA1 EFHD2 CCT7 QARS1 EIF3M RRP1	6.95e-05	1335	95	13	29229926
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	CUL4A EEF2 WDR36 RPLP0 CSAD CCT7 BTAF1 SEC63 TMBIM6 QARS1 EIF3M	7.00e-05	971	95	11	33306668
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	CUL4B CUL4A AP1B1 UBR4 SLFN11 EIF3M	7.07e-05	253	95	6	29911972
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	CUL4B CUL4A EEF2 SMARCA1 AP3D1	7.13e-05	156	95	5	22952844
Pubmed	CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy.	CUL4B CUL4A	7.34e-05	5	95	2	32466489
Pubmed	A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation.	PKHD1 SEC63	7.34e-05	5	95	2	21685914
Pubmed	Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex.	CUL4B CUL4A	7.34e-05	5	95	2	24719410
Pubmed	The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.	CUL4B CUL4A	7.34e-05	5	95	2	22118460
Pubmed	Subcellular localization of the Schlafen protein family.	SLFN13 SLFN11	7.34e-05	5	95	2	18355440
Pubmed	Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease.	CHM CHML	7.34e-05	5	95	2	15186776
Pubmed	Cullin 4A and 4B ubiquitin ligases interact with γ-tubulin and induce its polyubiquitination.	CUL4B CUL4A	7.34e-05	5	95	2	25542213
Pubmed	Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival.	CUL4B CUL4A	7.34e-05	5	95	2	27142104
Pubmed	Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis.	SLFN13 SLFN11	7.34e-05	5	95	2	29528433
Pubmed	Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.	CUL4B CUL4A	7.34e-05	5	95	2	26711351
Pubmed	Molecular double clips within RepID WD40 domain control chromatin binding and CRL4-substrate assembly.	CUL4B CUL4A	7.34e-05	5	95	2	34171797
Pubmed	Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation.	CUL4B CUL4A	7.34e-05	5	95	2	36056023
Pubmed	Chromosomal localization and genomic cloning of the mouse alpha-tropomyosin gene Tpm-1.	CYP1A2 SCN5A	7.34e-05	5	95	2	8406508
Pubmed	Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma.	SLFN13 SLFN11	7.34e-05	5	95	2	24089532
Pubmed	Selective degradation of splicing factor CAPERα by anticancer sulfonamides.	CUL4B CUL4A	7.34e-05	5	95	2	28437394
Pubmed	The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels.	CUL4B CUL4A	7.34e-05	5	95	2	26021757
Pubmed	Regulation of liver receptor homologue-1 by DDB2 E3 ligase activity is critical for hepatic glucose metabolism.	CUL4B CUL4A	7.34e-05	5	95	2	30923324
Interaction	FBXO32 interactions	CUL4B CUL4A EEF2 RPLP0 NSF CCT7 TNNC2 NME7 ARMH3 TRIP12 EIF3M	2.04e-06	386	95	11	int:FBXO32
Interaction	SENP3 interactions	EEF2 ACTR8 RPLP0 POLR1E SLFN11 SEC63 QARS1 IFI16 TRIP12	1.25e-05	301	95	9	int:SENP3
Interaction	ARHGAP24 interactions	CUL4B EEF2 AP1B1 GPS1 SMARCA1 CCT7 SEC63 QARS1 DHTKD1 VPS53 PGM1	1.80e-05	486	95	11	int:ARHGAP24
Interaction	ENO1 interactions	CUL4B CUL4A EEF2 ATP6V0A1 AP1B1 FAM186A GPS1 VPS13A CCT7 SEC63 IFI16 C3orf20 PGM1	2.47e-05	701	95	13	int:ENO1
Interaction	ATG16L1 interactions	CWF19L2 EEF2 ERCC6L TTLL6 CEP95 ST7 TBC1D1 KCTD10 EFHD2 CCT7 EXOC1 WDFY3 RAB11FIP1 TRIP12 MAP2K7 EIF3M RRP1	2.71e-05	1161	95	17	int:ATG16L1
Interaction	TMSB4Y interactions	SNRNP27 WBP11 TRIP12 RRP1	3.36e-05	39	95	4	int:TMSB4Y
Interaction	LMBR1L interactions	ATP6V0A1 KIDINS220 AP1B1 ERCC6L XPO5 NSF UBR4 GPS1 UGGT2 BTAF1 SEC63 QARS1 TRIP12 VPS53 RRP1	3.47e-05	946	95	15	int:LMBR1L
Interaction	SNRNP40 interactions	CUL4B CUL4A SNRNP27 CWF19L2 WBP11 WDR36 POLR1E ARID2 GPS1 SMARCA1 SLFN11 RBM41	4.47e-05	637	95	12	int:SNRNP40
Interaction	MAP1B interactions	CUL4A WBP11 EEF2 NSF UBR4 GPS1 CCT7 SLFN11 QARS1 IFI16 MAP2K7	4.64e-05	539	95	11	int:MAP1B
Interaction	SHLD2 interactions	CUL4B CCT7 QARS1 TRIP12	4.97e-05	43	95	4	int:SHLD2
Interaction	WDR5B interactions	CUL4B CUL4A SNRNP27 CCT7	9.04e-05	50	95	4	int:WDR5B
Interaction	CHMP4C interactions	CUL4A SNRNP27 EEF2 WDR36 RPLP0 RPLP0P6 CHMP3 EFHD2 IFI16 EIF3M PGM1 RRP1	9.20e-05	687	95	12	int:CHMP4C
Interaction	GRWD1 interactions	CUL4B CUL4A EEF2 WDR36 POLR1E UBR4 CCT7 QARS1 IFI16	9.41e-05	390	95	9	int:GRWD1
Interaction	SOX2 interactions	CUL4B CUL4A EEF2 KIDINS220 WDR36 RPLP0 XPO5 NSF ST7 ARID2 UBR4 GPS1 EFHD2 CCT7 SLFN11 QARS1 TRIP12 RRP1	1.02e-04	1422	95	18	int:SOX2
GeneFamily	Schlafen family	SLFN13 SLFN11	2.25e-04	7	60	2	1110
GeneFamily	Cullins	CUL4B CUL4A	2.99e-04	8	60	2	1032
GeneFamily	EF-hand domain containing	EFHD1 EFHD2 PLCD4 TNNC2 AIF1L	7.92e-04	219	60	5	863
GeneFamily	INO80 complex \|SRCAP complex	ACTR8 ACTR5	1.11e-03	15	60	2	595
Disease	Down syndrome (biomarker_via_orthology)	RPLP0 RPLP0P6	9.62e-06	2	92	2	DOID:14250 (biomarker_via_orthology)
Disease	choroideremia (implicated_via_orthology)	CHM CHML	9.62e-06	2	92	2	DOID:9821 (implicated_via_orthology)
Disease	ATRIAL SEPTAL DEFECT 1	MYT1L TRIP12	2.88e-05	3	92	2	C1862389
Disease	Atrial Septal Defects	MYT1L TRIP12	9.56e-05	5	92	2	C0018817
Disease	Paroxysmal atrial fibrillation	CUL4A SNRNP27 SCMH1 SCN5A ARMH3	1.32e-04	156	92	5	C0235480
Disease	familial atrial fibrillation	CUL4A SNRNP27 SCMH1 SCN5A ARMH3	1.32e-04	156	92	5	C3468561
Disease	Persistent atrial fibrillation	CUL4A SNRNP27 SCMH1 SCN5A ARMH3	1.32e-04	156	92	5	C2585653
Disease	Atrial Fibrillation	CUL4A SNRNP27 SCMH1 SCN5A ARMH3	1.48e-04	160	92	5	C0004238
Disease	thoracic aortic calcification measurement	COL6A6 VPS13A	3.41e-04	9	92	2	EFO_0010273
Disease	glaucoma (is_implicated_in)	EEF2 WDR36	4.26e-04	10	92	2	DOID:1686 (is_implicated_in)
Disease	TPE interval measurement	KCNJ4 SCN5A PRAG1	5.80e-04	52	92	3	EFO_0004644
Disease	Coffin-Siris syndrome	ARID2 SMARCA1	7.33e-04	13	92	2	C0265338
Disease	chromosome 22q11.2 deletion syndrome, distal (implicated_via_orthology)	PI4KAP2 PRODH	8.54e-04	14	92	2	DOID:0060413 (implicated_via_orthology)
Disease	JT interval	CUL4A KCNJ4 ARID2 SCN5A NME7	1.09e-03	248	92	5	EFO_0007885
Disease	fourth ventricle volume measurement	CWF19L2 MIPEP	1.12e-03	16	92	2	EFO_0010303
Disease	chronotype measurement	SNRNP27 RGS7BP KCNJ4 ARID2 PKHD1 KBTBD2 QARS1 PRAG1 MGAT5B	1.74e-03	882	92	9	EFO_0008328
Disease	blood urea nitrogen measurement	CYP1A2 MIPEP PKHD1 PLCD4 UGGT2 SLC1A7	2.94e-03	452	92	6	EFO_0004741
Disease	Neurodevelopmental Disorders	MYT1L WDFY3 TRIP12	3.11e-03	93	92	3	C1535926

Protein segments in the cluster

Peptide	Gene	Start	Entry
MMLLSEGMKEEGLFR	BARGIN	306	Q6ZT62
EIDLMSLKRMMEKLG	AIF1L	66	Q9BQI0
MLKAMFSGRMEVLTD	KCTD10	56	Q9H3F6
MDMMGGVLEVKKEDI	CFAP43	1121	Q8NDM7
FREATMKMAVMIFKR	CFAP54	346	Q96N23
MKMAVMIFKRGVFES	CFAP54	351	Q96N23
TMRELSKEMMKAGII	CHMP3	126	Q9Y3E7
SKEMMKAGIIEEMLE	CHMP3	131	Q9Y3E7
FKMRKDDIMLDEGML	C8A	301	P07357
KELVNMILMKMGFSG	ACTR8	246	Q9H981
MMELFIRLKEILNQM	ABCA12	666	Q86UK0
KCLMSRDRFLKMRGM	ARID2	361	Q68CP9
MLMGFDKAELCMKNL	ARMH3	126	Q5T2E6
VLSAVKVLMKFMEML	AP1B1	256	Q10567
PGMKARMEKELLEMR	ACTR5	501	Q9H9F9
MMDLFVQMAIIMGLK	ANO9	471	A1A5B4
VQSRMEKMMDGIKLD	DHTKD1	556	Q96HY7
MALKMVKGSIDRMFD	AP3D1	1	O14617
MVKGLKNMDGMLVVE	MROH7	1046	Q68CQ1
EGANKMMKDLEALMF	PGM1	436	P36871
QLTMVEKRMLMKFLT	CHM	286	P24386
MVEKRMLMKFLTFCL	CHML	291	P26374
MREMKNLLSKLRETM	RGS7BP	206	Q6MZT1
MIMKKRLEEFQLMRG	RBM41	196	Q96IZ5
EKMMLFGMGKRRCIG	CYP1A2	446	P05177
FMIGTIMAKMARPKK	KCNJ4	166	P48050
FMKVLKCEVELMARM	KIDINS220	741	Q9ULH0
EAGMLMHFILRKYKM	MAGEB1	111	P43366
RKYKMREPIMKADML	MAGEB1	121	P43366
KMRLLTFMGMAVENK	EIF3M	276	Q7L2H7
LRKMSDLLELMVKRM	MGAT5B	71	Q3V5L5
IMEAMEKLKSGMRFN	PIN4	51	Q9Y237
MELMGTCAEKLKKRM	MAP2K7	196	O14733
LGAKIIKAEMMGNME	CWF19L2	496	Q2TBE0
LMGKEFQRRAKAMML	GPS1	441	Q13098
FFKPRLGMTKEEMMI	KBTBD2	256	Q8IY47
GIKKLLMLIEMSLQM	NSF	706	P46459
AVVLMGKNTMMRKAI	RPLP0	51	P05388
MMTYNLILKGIEKMD	PRKG2	656	Q13237
ELMMRYLKAMGHKFL	CABIN1	486	Q9Y6J0
QFPGELLMRMLKMMI	SLC1A7	51	O00341
DFVVMRARMMAAKLL	BTAF1	671	O14981
LEGMFKDMELSKDIM	CUL4A	491	Q13619
TELLRLKMKAMVESM	C3orf20	146	Q8ND61
MAKMFDLRTKIMIGI	FAM24A	1	A6NFZ4
ERLMTLKIAEMKEAM	ADA2	61	Q9NZK5
MMRMRTREEMIFKKL	CEP95	681	Q96GE4
TVFRKLMMILAMNEK	TMBIM6	216	P55061
LKERMVKEGSMMIGY	CSAD	441	Q9Y600
KMNDFMRMQILKEGS	IFI16	451	Q16666
SKMNDFMRMQILKEG	IFI16	506	Q16666
RDGFIDLMELKLMME	EFHD1	106	Q9BUP0
DLMELKLMMEKLGAP	EFHD1	111	Q9BUP0
KDMIRQMMIKIFRCI	EXOC1	576	Q9NV70
AIAERIKPVLMMNKM	EEF2	146	P13639
FIDLMELKLMMEKLG	EFHD2	111	Q96C19
MMMLEQFRKVKRESP	FAM186A	541	A6NE01
KLGRKIEMALMVFDM	SEC14L4	141	Q9UDX3
TIMAMKIMEKIRNVF	SLFN13	606	Q68D06
EGMFKDMELSKDIMI	CUL4B	646	Q13620
AGFTITKLKMMMLSR	NME7	116	Q9Y5B8
MKEMMAFLVRDIKVR	COL6A6	1776	A6NMZ7
MEESGKMIFLMDLLK	ERCC6L	456	Q2NKX8
AKPIALMALKMMELS	GUCY1A2	586	P33402
KRMMEIAKAMRLKIS	POLR1E	366	Q9GZS1
TLRMKLVMEDGKMDP	QARS1	401	P47897
VVVLMGKNTMMRKAI	RPLP0P6	51	Q8NHW5
SMMRKLEEMGLNLRK	RAB11FIP1	786	Q6WKZ4
SGKMDKMRLLNILMQ	SMARCA1	441	P28370
LLMQEGMPMRKVRSK	PLCD4	16	Q9BRC7
KTEEEIEMMKLMGFA	SNRNP27	96	Q8WVK2
MTRMLQRMDVLAKKA	PRODH	356	O43272
GEMDALKIQMEEKFM	SCN5A	1866	Q14524
TIMAMKIMEKIRNVF	SLFN11	606	Q7Z7L1
AKMVVDAVMMLDDLL	CCT7	176	Q99832
LMRMVLNESLKVLKM	RRP1	121	P56182
VGEDMRMKVMLGKVN	PKHD1	3926	P08F94
VKMMRDLMKEFPLLS	ST7	316	Q9NRC1
IKLTDEMVMIMGGKM	PI4KAP2	481	A4QPH2
IDGKALLLLRSDMMM	SCMH1	621	Q96GD3
RMIGLTVGFDKKDMM	VPS13A	1471	Q96RL7
LEMTEGPCRMRKKMV	WDFY3	2371	Q8IZQ1
RTLKDFEMIRGMKMK	MIPEP	331	Q99797
KMLEAHIKTFRMRML	SPATA31D1	901	Q6ZQQ2
KMLKFLMFDMGLRKQ	TBC1D1	911	Q86TI0
MLAKMAEPFTKALDM	XPO5	791	Q9HAV4
MDMKRLIMVLAGASE	SEC63	241	Q9UGP8
KDLLARNMSRMLKMF	TTLL6	126	Q8N841
LMMMKFAEKAVDRRR	PRAG1	1361	Q86YV5
KGMTRAEMILKVVMA	VPS53	731	Q5VIR6
FMLYMKEMRAKVIAE	TCF7	276	P36402
FLVMMVRQMKEDAKG	TNNC2	76	P02585
FGVARMDVMKDVMLG	TRIM9	596	Q9C026
KMKMSVILGIIHMLF	ATP6V0A1	536	Q93050
ILDMLKLEGKMMNGL	UGGT2	396	Q9NYU1
QRMMVRAAVLKMKDP	WBP11	36	Q9Y2W2
GKLMAKAIMDFRLVD	TRIP12	1701	Q14669
EKKRMAMAMRQKALG	UBR4	4791	Q5T4S7
FLKMIGMMLDRKRDF	WDR36	876	Q8NI36
MGIDTMLRSLKEAMV	ZBED4	976	O75132
KAMREKMAMEAGRRD	MYT1L	446	Q9UL68