Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessmicrotubule cytoskeleton organization involved in establishment of planar polarity

BRSK2 BRSK1

4.23e-063252GO:0090176
GeneOntologyBiologicalProcessestablishment of planar polarity

BRSK2 CELSR1 BRSK1

2.02e-0544253GO:0001736
GeneOntologyBiologicalProcessestablishment of tissue polarity

BRSK2 CELSR1 BRSK1

2.16e-0545253GO:0007164
GeneOntologyBiologicalProcessregulation of axonogenesis

BRSK2 PLXNA4 BRSK1 SEMA7A

7.90e-05192254GO:0050770
GeneOntologyBiologicalProcessregulation of synaptic vesicle clustering

BRSK2 BRSK1

9.24e-0512252GO:2000807
GeneOntologyBiologicalProcessmorphogenesis of a polarized epithelium

BRSK2 CELSR1 BRSK1

9.25e-0573253GO:0001738
GeneOntologyBiologicalProcesssynaptic vesicle clustering

BRSK2 BRSK1

3.21e-0422252GO:0097091
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

BRSK2 PLXNA4 BRSK1 SEMA7A ENPP2 B3GNT2

3.56e-04819256GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

BRSK2 PLXNA4 BRSK1 SEMA7A ENPP2 B3GNT2

3.73e-04826256GO:0048858
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection organization

BRSK2 PLXNA4 BRSK1 SEMA7A ENPP2 HTT

4.24e-04846256GO:0120035
GeneOntologyBiologicalProcessregulation of cell projection organization

BRSK2 PLXNA4 BRSK1 SEMA7A ENPP2 HTT

4.71e-04863256GO:0031344
GeneOntologyBiologicalProcessaxonogenesis

BRSK2 PLXNA4 BRSK1 SEMA7A B3GNT2

5.15e-04566255GO:0007409
GeneOntologyBiologicalProcesstelencephalon development

PLXNA4 SEMA7A CSNK2A2 HTT

6.38e-04332254GO:0021537
DomainSEMA

PLXNA4 SEMA7A

7.19e-0431242PS51004
DomainSema

PLXNA4 SEMA7A

7.19e-0431242SM00630
DomainSemap_dom

PLXNA4 SEMA7A

7.19e-0431242IPR001627
DomainSema

PLXNA4 SEMA7A

7.19e-0431242PF01403
DomainPlexin_repeat

PLXNA4 SEMA7A

7.67e-0432242IPR002165
DomainPSI

PLXNA4 SEMA7A

7.67e-0432242PF01437
DomainPSI

PLXNA4 SEMA7A

1.45e-0344242IPR016201
DomainPSI

PLXNA4 SEMA7A

1.58e-0346242SM00423
DomainCa/CaM-dep_Ca-dep_prot_Kinase

BRSK2 BRSK1

3.52e-0369242IPR020636
DomainARM-type_fold

PSMD2 NUP188 HTT

9.04e-03339243IPR016024
DomainSer/Thr_kinase_AS

BRSK2 BRSK1 CSNK2A2

1.04e-02357243IPR008271
DomainS_TKc

BRSK2 BRSK1 CSNK2A2

1.06e-02359243SM00220
DomainPROTEIN_KINASE_ST

BRSK2 BRSK1 CSNK2A2

1.08e-02362243PS00108
DomainProtein_kinase_ATP_BS

BRSK2 BRSK1 CSNK2A2

1.22e-02379243IPR017441
DomainPkinase

BRSK2 BRSK1 CSNK2A2

1.24e-02381243PF00069
DomainPROTEIN_KINASE_ATP

BRSK2 BRSK1 CSNK2A2

2.03e-02459243PS00107
Pubmed

SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release.

BRSK2 BRSK1

4.96e-07225216630837
Pubmed

Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation.

BRSK2 BRSK1

4.96e-07225218339622
Pubmed

Neurochemical correlates of synapse density in a Huntington's disease mouse model.

CSNK2A2 HTT

4.96e-07225236272099
Pubmed

Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.

BRSK2 BRSK1

4.96e-07225230307479
Pubmed

Microtubule stabilization specifies initial neuronal polarization.

BRSK2 BRSK1

1.49e-06325218268107
Pubmed

Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells.

BRSK2 BRSK1

1.49e-06325222669945
Pubmed

Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity.

BRSK2 BRSK1

1.49e-06325220026642
Pubmed

Tuberous sclerosis complex proteins control axon formation.

BRSK2 BRSK1

2.97e-06425218794346
Pubmed

Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1α.

PSMD2 HTT

2.97e-06425224951540
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

NUP188 NEB CYP3A43 HTT

4.13e-0615225434299191
Pubmed

Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.

BRSK2 BRSK1

4.95e-06525215150265
Pubmed

C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.

BRSK2 BRSK1

4.95e-06525218854318
Pubmed

Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain.

PLXNA4 SEMA7A

4.95e-06525224831527
Pubmed

Mammalian SAD kinases are required for neuronal polarization.

BRSK2 BRSK1

7.43e-06625215705853
Pubmed

SAD kinases control the maturation of nerve terminals in the mammalian peripheral and central nervous systems.

BRSK2 BRSK1

7.43e-06625224395778
Pubmed

Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.

BRSK2 BRSK1

7.43e-06625221985311
Pubmed

LKB1 and AMPK regulate synaptic remodeling in old age.

BRSK2 BRSK1

7.43e-06625225086610
Pubmed

Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology.

MYOM2 NEB

2.22e-051025220368620
Pubmed

Molecular diversity of myofibrillar proteins: gene regulation and functional significance.

MYOM2 NEB

3.26e-05122528618961
Pubmed

Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.

BRSK2 BRSK1

3.26e-051225223275438
Pubmed

Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.

PLXNA4 SEMA7A

3.85e-051325210520995
Pubmed

The loss of the kinases SadA and SadB results in early neuronal apoptosis and a reduced number of progenitors.

BRSK2 BRSK1

3.85e-051325229698519
Pubmed

β3GnT2 maintains adenylyl cyclase-3 signaling and axon guidance molecule expression in the olfactory epithelium.

PLXNA4 B3GNT2

4.49e-051425221525298
Pubmed

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

BRSK2 BRSK1

5.18e-051525214976552
Pubmed

LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.

BRSK2 BRSK1

8.42e-051925217482548
Pubmed

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.

BRSK2 BRSK1

9.35e-052025218227155
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

CELSR1 NUP188 SETD1B SEMA7A IL17RD HTT

1.07e-04110525635748872
Pubmed

SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals.

BRSK2 BRSK1

1.24e-042325223790753
Pubmed

A semaphorin code defines subpopulations of spinal motor neurons during mouse development.

PLXNA4 SEMA7A

1.36e-042425215869472
Pubmed

Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring.

PLXNA4 SEMA7A

1.60e-042625239152101
Pubmed

Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.

PLXNA4 SEMA7A

1.85e-042825218617019
Pubmed

Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning.

PLXNA4 SEMA7A

1.85e-042825217951031
Pubmed

Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.

ZNF462 HTT

1.85e-042825225752541
Pubmed

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.

BRSK2 BRSK1

2.13e-043025216306228
Pubmed

STK11 is required for the normal program of ciliated cell differentiation in airways.

BRSK2 BRSK1

2.28e-043125231636950
Pubmed

Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.

MYOM2 NEB

3.62e-043925224703692
Pubmed

Roles of tau protein in health and disease.

BRSK2 BRSK1

3.80e-044025228386764
Pubmed

A High-Density Map for Navigating the Human Polycomb Complexome.

ZNF462 PSMD2 SETD1B CSNK2A2

4.04e-0449525427705803
Pubmed

Identification of HYPK-interacting proteins reveals involvement of HYPK in regulating cell growth, cell cycle, unfolded protein response and cell death.

ZNF462 HTT

5.95e-045025223272104
Pubmed

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.

SETD1B CSNK2A2

5.95e-045025237974198
Pubmed

An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.

PLXNA4 SEMA7A

6.43e-045225226633812
InteractionHSPH1 interactions

BRSK2 PSMD2 BRSK1 CSNK2A2 B3GNT2 HTT

1.44e-05448256int:HSPH1
GeneFamilyImmunoglobulin like domain containing

MYOM2 SEMA7A

1.55e-02193182594
ToppCellmild_COVID-19_(asymptomatic)-NK_CD56bright|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

FSIP2 NEB SEMA7A IL17RD ZNF404

2.01e-081512552470162f4b56bc505db166a6eb0fa54847759df8
ToppCellmild_COVID-19_(asymptomatic)-NK_CD56bright|World / disease group, cell group and cell class (v2)

NEB SEMA7A IL17RD ZNF404

1.54e-06153254aff5c8ab1fb4ebc324cec02cf562b7484bb10db8
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c02-NCAM1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

BRSK2 PLXNA4 ZNF462 CYP3A43

1.98e-061632541c014e373667be290d7fb5d24c06c6f313ac8fa3
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLXNA4 ZNF462 SEMA7A

6.87e-05143253d0ed8c25da1327085e042c2e03cb7503e2c52ce0
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLXNA4 ZNF462 SEMA7A

6.87e-051432538900b92a24289204b9ec7baccc11594fec7694f1
ToppCell343B-Myeloid-Dendritic-pDC|343B / Donor, Lineage, Cell class and subclass (all cells)

PLXNA4 SEMA7A ZNF404

8.89e-05156253547e2debfc09c07c049a880dded5fda7dd53e156
ToppCellCOVID_non-vent-Lymphocytic-Dendritic-pDC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

PLXNA4 SEMA7A ENPP2

9.58e-0516025361f4cb4eb4313d8318aadbb99595a6cb7fd919f7
ToppCellCOVID_non-vent-Lymphocytic-Dendritic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

PLXNA4 SEMA7A ENPP2

9.58e-0516025334b4f710cfcb6ec370b8b074f3cbfe272f392cec
ToppCellBronchial-10x5prime-Stromal-Schwann|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PLXNA4 MGAT4C ENPP2

9.94e-05162253afffecc6c504930554aafc12c5bffa53e3c5b016
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLXNA4 SEMA7A ENPP2

1.15e-0417025392e765ae0d3adb38d3b22fddb873fd5ccad3fd44
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLXNA4 SEMA7A ENPP2

1.15e-041702539f8b215caa1afa3cd7104c06fca7cfd790640f66
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLXNA4 SEMA7A ENPP2

1.15e-04170253b49f7c8a27078de2137ed04f74cfee30729cfa5e
ToppCellmild_COVID-19-pDC|World / disease group, cell group and cell class (v2)

PLXNA4 SEMA7A ENPP2

1.19e-04172253dab2f1a05c7df58d9387b13271b3f1f1583f9ac3
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CELSR1 BRSK1 B3GNT2

1.23e-04174253c0204a0d0a979a489e8d30dc5396e99da14c119c
ToppCellCTRL-Lymphoid-pDC|Lymphoid / Disease state, Lineage and Cell class

PLXNA4 FAP ENPP2

1.23e-04174253ff4315e9fad198cc323fc987deb8652da137cf98
ToppCellIIF-Myeloid-pDC|IIF / Disease, Lineage and Cell Type

PLXNA4 SEMA7A ENPP2

1.25e-0417525335cfb7d0b88678ff5b83ad6e19dbc15a908a3fcc
ToppCellmild_COVID-19-pDC|mild_COVID-19 / disease group, cell group and cell class (v2)

PLXNA4 SEMA7A ENPP2

1.25e-04175253b87f279a7519710146c49d6acccb0adedc195965
ToppCell(1)_Control_(PBS)-(2)_LEPR+_perivascular_cells_and_VE-Cad+_vascular_cells_(mixed)|(1)_Control_(PBS) / Stress and Cell class

FAP SEMA7A ENPP2

1.29e-04177253d9e5ac5b8949a77e88e8094079167e4cf2c1bbd1
ToppCellControl-Myeloid-pDC|Control / Disease state, Lineage and Cell class

PLXNA4 SEMA7A ENPP2

1.29e-041772533940663bb5b45b2ca9f772550380a516c53e410b
ToppCellControl-Myeloid-pDC|Myeloid / Disease state, Lineage and Cell class

PLXNA4 SEMA7A ENPP2

1.29e-04177253e82115bfc32c7b689460fbc5caeb983c1aabe30f
ToppCellSevere-B_intermediate-10|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

MYOM2 NEB SEMA7A

1.31e-04178253b7374a97c51239782bed658381a02cb1b3d9bf66
ToppCellHealthy/Control-pDC|Healthy/Control / Disease group and Cell class

PLXNA4 SEMA7A ENPP2

1.31e-04178253072b346c6bbd63f00efaceda486400a669b3ec48
ToppCellControl-Myeloid-pDC|World / Disease state, Lineage and Cell class

PLXNA4 SEMA7A ENPP2

1.31e-0417825320ef63d925e67ddd5955832312ca8574a6f838a4
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Endothelial|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA4 GVINP1 SEMA7A

1.36e-04180253f9b7d5eb7b6ea72253c89bdc351ad2b4a53f7d8e
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Endothelial-endothelial_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA4 GVINP1 SEMA7A

1.36e-0418025353db6032eda0e590ae7e01c9c3b472785ea6782f
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Endothelial-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA4 GVINP1 SEMA7A

1.36e-0418025328bc10b9d0e4430b952260014d8a6ff337860ac6
ToppCell3'_v3-Lung-Myeloid_Dendritic-pDC|Lung / Manually curated celltypes from each tissue

PLXNA4 SEMA7A ENPP2

1.38e-041812533d7f089fb434fbc989f1fa159e22133ae00b2487
ToppCellsystemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PLXNA4 SEMA7A ENPP2

1.40e-041822539bbe8062aa562dc3b9c299581faf6ebbcb72a9f7
ToppCellsystemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PLXNA4 SEMA7A ENPP2

1.40e-041822534602a98df7045e2c70b7560abfba9b444fbd5d30
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLXNA4 SEMA7A ENPP2

1.43e-04183253df6fd0927b6e4cf9a1583969a68096e4bccfbace
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLXNA4 SEMA7A ENPP2

1.43e-041832533b123571e10c132227aff65648b4b3c6acb4bd00
ToppCellsystemic_lupus_erythematosus-managed-Myeloid-plasmacytoid_dendritic_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PLXNA4 SEMA7A ENPP2

1.47e-04185253cc5152d3055375172bdf84f442b233c8fbd422b3
ToppCellnormal-na-Myeloid-plasmacytoid_dendritic_cell-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

PLXNA4 SEMA7A ENPP2

1.47e-041852533091870a5bf8ecb963e560b47c8502bae367416c
ToppCellHealthy_donor-pDC|Healthy_donor / disease group, cell group and cell class (v2)

PLXNA4 SEMA7A ENPP2

1.47e-041852537fbb55cbdb39bdecb6063c8ba9776ab06c2666e8
ToppCell(1)_Control_(PBS)-(2)_LEPR+_perivascular_cells_and_VE-Cad+_vascular_cells_(mixed)|World / Stress and Cell class

FAP SEMA7A ENPP2

1.47e-04185253b8cd94cf18308b514fc61557550225794ffd2860
ToppCellPBMC-Severe-Myeloid-pDC-pDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLXNA4 SEMA7A ENPP2

1.50e-04186253b70cd94c651b56dcf2e55554533a5f1130845390
ToppCellPBMC-Severe-Myeloid-pDC-pDC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLXNA4 SEMA7A ENPP2

1.50e-0418625331df1eafa3010bc1be6fc4d4689f1393d69b6b13
ToppCellPBMC-Severe-Myeloid-pDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLXNA4 SEMA7A ENPP2

1.50e-04186253eaa431ccd4cdd36fe06a44987603ec9979025aa8
ToppCellCOVID-19_Severe-Myeloid-pDC|COVID-19_Severe / Disease group, lineage and cell class

PLXNA4 SEMA7A ENPP2

1.50e-041862533db5ed69d49e5d79f990aca0295ddce4c297a05c
ToppCellPBMC-Severe-Myeloid-pDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PLXNA4 SEMA7A ENPP2

1.50e-04186253b95be984e308d4f9061274a35995ec558d434e74
ToppCellPBMC-Severe-Myeloid-pDC-pDC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PLXNA4 SEMA7A ENPP2

1.50e-041862538f7949740286f64e034d1eb533ebc2c6f71ae966
ToppCellPBMC-Severe-Myeloid-pDC-pDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PLXNA4 SEMA7A ENPP2

1.50e-0418625395c7318e521fb6aa02e244b1e81e6b2a62107756
ToppCellHealthy_donor-pDC|World / disease group, cell group and cell class (v2)

PLXNA4 SEMA7A ENPP2

1.52e-04187253aa2cc54487d3c5045ac0c93560944c5a55878e27
ToppCellCOVID-19_Severe-pDC-|COVID-19_Severe / Disease condition and Cell class

PLXNA4 SEMA7A ENPP2

1.54e-041882539fd1116e31a05554850b8ed3c005ea660dfbd51c
ToppCellPBMC-Mild-Myeloid-pDC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

PLXNA4 SEMA7A ENPP2

1.54e-04188253de6a270b6e4fe09c39a52c296632d86ada98465b
ToppCellPBMC-Mild-Myeloid-pDC-pDC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

PLXNA4 SEMA7A ENPP2

1.54e-0418825389411c4db3df5e1dc36cf8af4ffcc0abbecbe4df
ToppCellCOVID-19_Mild-pDC|COVID-19_Mild / Disease condition and Cell class

PLXNA4 SEMA7A ENPP2

1.54e-0418825362d33d2990d4a2d32bd0863147e47f656df1966e
ToppCellPBMC-Mild-Myeloid-pDC-pDC-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PLXNA4 SEMA7A ENPP2

1.54e-04188253879054b780378ae05be68e597c77c931bf0ade03
ToppCellCOVID-19_Mild-pDC-|COVID-19_Mild / Disease condition and Cell class

PLXNA4 SEMA7A ENPP2

1.54e-04188253a75c2cf2f8dae343c13aaa66b637658b935ed10a
ToppCellCOVID-19_Severe-pDC|COVID-19_Severe / Disease condition and Cell class

PLXNA4 SEMA7A ENPP2

1.54e-04188253475008f45673b42b75ef231c2df91f8b9adc9201
ToppCellPBMC-Mild-Myeloid-pDC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLXNA4 SEMA7A ENPP2

1.57e-04189253209cae68d78c8f72479b169e27c3ff7e143adece
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic-pDC|lymph-node_spleen / Manually curated celltypes from each tissue

PLXNA4 SEMA7A ENPP2

1.57e-041892536c2ace61a7d62bcf7e76b73e2da8b722d03e713b
ToppCellPBMC-Mild-Myeloid-pDC-pDC-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLXNA4 SEMA7A ENPP2

1.57e-04189253a9ad1fb12304541f909dd0eeac9b9eb28c31fd41
ToppCellCOVID-19_Mild-Myeloid-pDC|COVID-19_Mild / Disease group, lineage and cell class

PLXNA4 SEMA7A ENPP2

1.57e-04189253c6cfd6aa21c19f2c62d80218bbc924e14e82aada
ToppCellPBMC-Mild-Myeloid-pDC-pDC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLXNA4 SEMA7A ENPP2

1.57e-0418925398ca646231fbd5f29827c2dd31ac4503026bad7d
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Neuron|GW09 / Sample Type, Dataset, Time_group, and Cell type.

PLXNA4 MYOM2 BRSK1

1.57e-041892533717d1148e26ac78a26aea0ca1dbfbb9d3668877
ToppCell3'_v3-bone_marrow-Myeloid_Dendritic-pDC|bone_marrow / Manually curated celltypes from each tissue

PLXNA4 SEMA7A ENPP2

1.59e-04190253dde0e34f6a06cdbbb65c86472360c09f0279a572
ToppCell3'_v3-bone_marrow-Myeloid_Dendritic|bone_marrow / Manually curated celltypes from each tissue

PLXNA4 SEMA7A ENPP2

1.59e-041902536892c603037b61ef88d6ca01b7592dc0d347d63b
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic|lymph-node_spleen / Manually curated celltypes from each tissue

PLXNA4 SEMA7A ENPP2

1.62e-04191253c3ff4342e0eea1e1f071b1fbca14a6dd4df0c696
ToppCellsystemic_lupus_erythematosus-managed-Myeloid-plasmacytoid_dendritic_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PLXNA4 SEMA7A ENPP2

1.62e-041912538c487704cbbb5eeff54e8c6fb6fffa1472b5351f
ToppCellsystemic_lupus_erythematosus-managed-Myeloid-plasmacytoid_dendritic_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PLXNA4 SEMA7A ENPP2

1.62e-0419125378d523f562d32fc408a20d99b0c61cc103241bc0
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FAP MGAT4C ENPP2

1.64e-04192253d0649410cf5eacdb0c1dce70e37c7473ef5fddfa
ToppCellHealthy-B_intermediate|Healthy / disease group, cell group and cell class

CELSR1 NEB ZNF107

1.69e-04194253aabee48bf689367edae2079b4b90d253715f1097
ToppCellproximal-3-Endothelial-Vein|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GVINP1 SEMA7A CSNK2A2

1.72e-04195253c81eb541c15b866f9b6ca6a5f1751c5f1243f4fb
ToppCellproximal-Endothelial-Vein|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GVINP1 SEMA7A CSNK2A2

1.72e-041952530aebdd635a956dd2367883c1cf73d73ce9790635
ToppCellBiopsy_Control_(H.)-Immune-pDCs|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

PLXNA4 SEMA7A ENPP2

1.72e-0419525347d139215f0b51f5ea9b5fb09b1100e320e3f1e2
ToppCellproximal-Endothelial-Vein-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GVINP1 SEMA7A CSNK2A2

1.72e-04195253df00f94facc5d6107aac83cef3c64fefc7f8e562
ToppCellHealthy-B_intermediate|World / disease group, cell group and cell class

CELSR1 NEB ZNF107

1.72e-041952539de79e0bdd9063ae65e5edb89cc3fe6f9a8173bc
ToppCellBronchial-NucSeq-Stromal-Mesofibroblastic-Mesothelia|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NEB MGAT4C CYP3A43

1.74e-04196253ce13af36fc2932e8125013041742593ff3d07e86
ToppCellBronchial-NucSeq-Stromal-Mesofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NEB MGAT4C CYP3A43

1.74e-0419625396e5c6d155273e82ebafa180df8bb589c3e3e54e
ToppCellCOVID-19-COVID-19_Severe-Myeloid-pDC|COVID-19_Severe / Disease, condition lineage and cell class

PLXNA4 SEMA7A ENPP2

1.80e-04198253033ed362333e1d33f2aeea8da5865d2228d154dc
ToppCellMS-IIF-Myeloid-pDC|IIF / Disease, condition lineage and cell class

PLXNA4 SEMA7A ENPP2

1.82e-04199253e262ee854e64d87460bee810c14d6cbe744460e8
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-3|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

FAP IL17RD CYP3A43

1.82e-0419925307b8c33342c62afd9c63ec2d757cfa3ba65d2a98
ToppCellCOVID-19-COVID-19_Mild-Myeloid-pDC|COVID-19_Mild / Disease, condition lineage and cell class

PLXNA4 SEMA7A ENPP2

1.82e-041992539de61e5189d907cc969ac3043d68204f70acc0bf
ToppCellmLN-(5)_Dendritic_cell-(54)_pDC|mLN / shred on region, Cell_type, and subtype

PLXNA4 SEMA7A ENPP2

1.82e-041992531e738219784a446ee8b0ddeb408e0050e1929e60
ToppCellmLN-Dendritic_cell-pDC|mLN / Region, Cell class and subclass

PLXNA4 SEMA7A ENPP2

1.82e-0419925354f1abb57af7bf8a8b82a38b933f257df3b5d8df
ToppCell(54)_pDC|World / shred on Cell_type and subtype

PLXNA4 SEMA7A ENPP2

1.93e-04203253b8ba3e51770ff7b45cd02472f3e63aa4d5816f6f
Drug3,5-heptanedione

ENPP2 HTT

1.16e-055252CID000081923
DrugSAR 020106

BRSK2 BRSK1

2.42e-057252ctd:C547874
Drug17-AAG; Down 200; 1uM; PC3; HT_HG-U133A

TDRD7 ZNF107 CSNK2A2 B3GNT2

5.29e-051912541225_DN
DrugClindamycin hydrochloride [21462-39-5]; Up 200; 8.6uM; MCF7; HT_HG-U133A

NUP188 NEB SEMA7A ENPP2

5.40e-051922542219_UP
DrugEnilconazole [35554-44-0]; Up 200; 13.4uM; MCF7; HT_HG-U133A

NEB MGAT4C ENPP2 CYP3A43

6.20e-051992545538_UP
Drugxestospongin C

ENPP2 HTT

7.59e-0512252ctd:C511704
Diseaseserine/threonine-protein kinase BRSK2 measurement

BRSK2 BRSK1

2.07e-063252EFO_0803063
Diseasemajor depressive episode, major depressive disorder

SETD1B ENPP2

4.03e-0435252EFO_0007634, MONDO_0002009
Diseasehepatocyte growth factor measurement

MGAT4C HTT

6.38e-0444252EFO_0006903
Diseasemajor depressive episode

SETD1B ENPP2

7.28e-0447252EFO_0007634
Diseaseneuroimaging measurement

BRSK2 ZNF462 CELSR1 ENPP2 HTT

1.79e-031069255EFO_0004346
Diseasemosaic loss of chromosome Y measurement

ZNF462 PSMD2

2.09e-0380252EFO_0007783
Diseasealcohol drinking

TDRD7 PLXNA4

2.14e-0381252EFO_0004329
Diseasegrip strength measurement

CELSR1 NSUN3 BRSK1

3.14e-03350253EFO_0006941
Disease3-hydroxypropylmercapturic acid measurement

PLXNA4 MGAT4C CSNK2A2

3.19e-03352253EFO_0007014
DiseaseGlobal developmental delay

BRSK2 ZNF462

5.65e-03133252C0557874
DiseaseIntellectual Disability

BRSK2 ZNF462 HTT

6.20e-03447253C3714756
Diseaseneurodegenerative disease (implicated_via_orthology)

PSMD2 HTT

6.68e-03145252DOID:1289 (implicated_via_orthology)
Diseasemyeloid white cell count

PSMD2 FAP SETD1B HTT

7.51e-03937254EFO_0007988

Protein segments in the cluster

PeptideGeneStartEntry
LLQHLGLEHYYPKKL

GVINP1

861

Q7Z2Y8
KHHYYGKKGIVSLLR

CELSR1

2641

Q9NYQ6
KLGYIGKLYHSHDLP

MGAT4C

256

Q9UBM8
YPFELEKDLHLKGYH

NSUN3

61

Q9H649
YLHYKLKHEGPFKRK

IL17RD

231

Q8NFM7
PHVLKLHDVYENKKY

BRSK2

76

Q8IWQ3
HDPHLKAYYKRKDIL

FSIP2

101

Q5CZC0
LFKLGEPYHKKEHYL

PLXNA4

146

Q9HCM2
YHLPSYLKLHDVLKA

HTT

1231

P42858
LLYIYGTHSHKLFKK

CYP3A43

21

Q9HB55
YGYLKKYHIDLDPHF

CSNK2A2

256

P19784
PHVLKLHDVYENKKY

BRSK1

91

Q8TDC3
FKPYLKQHLPKRLHY

ENPP2

421

Q13822
LKFLRPHYGKLKEIY

PSMD2

96

Q13200
IDPALKKGHHKLYRY

SETD1B

36

Q9UPS6
KLPHFYKELYKEDLN

TDRD7

256

Q8NHU6
IHNAGPHRDKKLKYY

B3GNT2

276

Q9NY97
KIFSDKDGYKHIHYI

FAP

366

Q12884
HKIIHTGEKPYKYEE

ZNF107

206

Q9UII5
LIAVLAKYIYHKHDP

NUP188

851

Q5SRE5
PLKTPLFHSKYHYQK

SEMA7A

396

O75326
YKKGFRKYLHLTEHL

ZNF404

136

Q494X3
YFYALRKHIKKDHPA

ZNF462

1276

Q96JM2
PILGYYLDKREVHHK

MYOM2

741

P54296
YKYKEGYRKQLGHHI

NEB

3521

P20929