Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glycogen synthase activity, transferring glucose-1-phosphate	GYS1 GYS2	1.63e-05	2	81	2	GO:0061547
GeneOntologyMolecularFunction	alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity	GYS1 GYS2	4.86e-05	3	81	2	GO:0004373
GeneOntologyMolecularFunction	hydroperoxy icosatetraenoate dehydratase activity	CYP1A2 CYP2S1	3.37e-04	7	81	2	GO:0106256
GeneOntologyMolecularFunction	GPI-linked ephrin receptor activity	EPHA3 EPHA5	3.37e-04	7	81	2	GO:0005004
Domain	DnaJ_domain_CS	DNAJB12 DNAJB1 DNAJB4 DNAJB8	5.89e-06	27	83	4	IPR018253
Domain	Glycogen_synth	GYS1 GYS2	1.95e-05	2	83	2	IPR008631
Domain	Glycogen_syn	GYS1 GYS2	1.95e-05	2	83	2	PF05693
Domain	RNA_pol_Rpb1_2	POLR2A POLR3A	5.84e-05	3	83	2	PF00623
Domain	DUF716_TMEM45	TMEM45B TMEM45A	5.84e-05	3	83	2	IPR006904
Domain	RPOLA_N	POLR2A POLR3A	5.84e-05	3	83	2	SM00663
Domain	RNA_pol_Rpb1_4	POLR2A POLR3A	5.84e-05	3	83	2	IPR007083
Domain	RNA_pol_Rpb1_5	POLR2A POLR3A	5.84e-05	3	83	2	IPR007081
Domain	RNA_pol_Rpb1_1	POLR2A POLR3A	5.84e-05	3	83	2	IPR007080
Domain	RNA_pol_Rpb1_3	POLR2A POLR3A	5.84e-05	3	83	2	IPR007066
Domain	DUF716	TMEM45B TMEM45A	5.84e-05	3	83	2	PF04819
Domain	RNA_pol_asu	POLR2A POLR3A	5.84e-05	3	83	2	IPR000722
Domain	RNA_pol_N	POLR2A POLR3A	5.84e-05	3	83	2	IPR006592
Domain	RNA_pol_Rpb1_1	POLR2A POLR3A	5.84e-05	3	83	2	PF04997
Domain	RNA_pol_Rpb1_5	POLR2A POLR3A	5.84e-05	3	83	2	PF04998
Domain	RNA_pol_Rpb1_3	POLR2A POLR3A	5.84e-05	3	83	2	PF04983
Domain	RNA_pol_Rpb1_4	POLR2A POLR3A	5.84e-05	3	83	2	PF05000
Domain	DnaJ	DNAJB12 DNAJB1 DNAJB4 DNAJB8	6.08e-05	48	83	4	PF00226
Domain	DNAJ_1	DNAJB12 DNAJB1 DNAJB4 DNAJB8	6.60e-05	49	83	4	PS00636
Domain	DNAJ_2	DNAJB12 DNAJB1 DNAJB4 DNAJB8	6.60e-05	49	83	4	PS50076
Domain	DnaJ	DNAJB12 DNAJB1 DNAJB4 DNAJB8	6.60e-05	49	83	4	SM00271
Domain	-	DNAJB12 DNAJB1 DNAJB4 DNAJB8	6.60e-05	49	83	4	1.10.287.110
Domain	DnaJ_domain	DNAJB12 DNAJB1 DNAJB4 DNAJB8	7.73e-05	51	83	4	IPR001623
Domain	DnaJ_C	DNAJB1 DNAJB4	6.88e-04	9	83	2	IPR002939
Domain	DnaJ_C	DNAJB1 DNAJB4	6.88e-04	9	83	2	PF01556
Domain	HSP40/DnaJ_pept-bd	DNAJB1 DNAJB4	6.88e-04	9	83	2	IPR008971
Domain	fn3	OBSCN MYOM2 ITGB4 EPHA3 EPHA5	7.77e-04	162	83	5	PF00041
Domain	PROTEIN_KINASE_TYR	OBSCN SYK EPHA3 EPHA5	9.18e-04	97	83	4	PS00109
Domain	Tyr_kinase_AS	OBSCN SYK EPHA3 EPHA5	9.18e-04	97	83	4	IPR008266
Domain	FN3	OBSCN MYOM2 ITGB4 EPHA3 EPHA5	1.40e-03	185	83	5	SM00060
Domain	RECEPTOR_TYR_KIN_V_2	EPHA3 EPHA5	1.72e-03	14	83	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHA3 EPHA5	1.72e-03	14	83	2	PS00790
Domain	Eph_TM	EPHA3 EPHA5	1.72e-03	14	83	2	IPR027936
Domain	Tyr_kinase_rcpt_V_CS	EPHA3 EPHA5	1.72e-03	14	83	2	IPR001426
Domain	EPH_lbd	EPHA3 EPHA5	1.72e-03	14	83	2	SM00615
Domain	Ephrin_lbd	EPHA3 EPHA5	1.72e-03	14	83	2	PF01404
Domain	EphA2_TM	EPHA3 EPHA5	1.72e-03	14	83	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHA3 EPHA5	1.72e-03	14	83	2	IPR016257
Domain	Ephrin_rcpt_lig-bd_dom	EPHA3 EPHA5	1.72e-03	14	83	2	IPR001090
Domain	EPH_LBD	EPHA3 EPHA5	1.72e-03	14	83	2	PS51550
Domain	FN3	OBSCN MYOM2 ITGB4 EPHA3 EPHA5	1.94e-03	199	83	5	PS50853
Domain	FN3_dom	OBSCN MYOM2 ITGB4 EPHA3 EPHA5	2.40e-03	209	83	5	IPR003961
Domain	CH	MICAL2 DMD SMTNL2	3.03e-03	65	83	3	SM00033
Domain	CH	MICAL2 DMD SMTNL2	3.74e-03	70	83	3	PF00307
Domain	-	MICAL2 DMD SMTNL2	3.89e-03	71	83	3	1.10.418.10
Domain	CH	MICAL2 DMD SMTNL2	4.21e-03	73	83	3	PS50021
Domain	CH-domain	MICAL2 DMD SMTNL2	4.54e-03	75	83	3	IPR001715
Domain	Chromo_domain	CHD9 CHD4	5.05e-03	24	83	2	IPR023780
Domain	Ephrin_rec_like	EPHA3 EPHA5	5.48e-03	25	83	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHA3 EPHA5	5.48e-03	25	83	2	IPR011641
Domain	Chromo	CHD9 CHD4	5.92e-03	26	83	2	PF00385
Domain	G-protein_beta_WD-40_rep	GRWD1 PWP2 STRN4	6.43e-03	85	83	3	IPR020472
Domain	CHROMO_1	CHD9 CHD4	6.84e-03	28	83	2	PS00598
Domain	CHROMO_2	CHD9 CHD4	6.84e-03	28	83	2	PS50013
Domain	TyrKc	SYK EPHA3 EPHA5	7.08e-03	88	83	3	SM00219
Domain	Tyr_kinase_cat_dom	SYK EPHA3 EPHA5	7.08e-03	88	83	3	IPR020635
Pubmed	Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature.	DNAJB12 DNAJB1 DNAJB4 DNAJB8	2.24e-07	22	84	4	11147971
Pubmed	The RabGAPs EPI64A and EPI64B regulate the apical structure of epithelial cells †.	TBC1D10B TBC1D10A	5.76e-06	2	84	2	34757852
Pubmed	Regulation of VEGFR2 trafficking and signaling by Rab GTPase-activating proteins.	TBC1D10B TBC1D10A	5.76e-06	2	84	2	31527750
Pubmed	β4 integrin marks interstitial myogenic progenitor cells in adult murine skeletal muscle.	DMD ITGB4	5.76e-06	2	84	2	22205679
Pubmed	SYK interaction with ITGβ4 suppressed by Epstein-Barr virus LMP2A modulates migration and invasion of nasopharyngeal carcinoma cells.	SYK ITGB4	5.76e-06	2	84	2	25531330
Pubmed	EphrinA/EphA-induced ectodomain shedding of neural cell adhesion molecule regulates growth cone repulsion through ADAM10 metalloprotease.	EPHA3 EPHA5	1.73e-05	3	84	2	24117969
Pubmed	Identification of ocular regulatory functions of core histone variant H3.2.	EPHA3 EPHA5	1.73e-05	3	84	2	36529279
Pubmed	Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.	TBC1D10B TBC1D10A	1.73e-05	3	84	2	20404108
Pubmed	The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.	DNAJB1 DNAJB4 DNAJB8	2.32e-05	23	84	3	21231916
Pubmed	RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.	DNAJB12 DNAJB1 OBSCN DNAJB4 PCBP2	3.07e-05	148	84	5	35676246
Pubmed	Disruption of ephrin signaling associates with disordered axophilic migration of the gonadotropin-releasing hormone neurons.	EPHA3 EPHA5	3.45e-05	4	84	2	15788771
Pubmed	Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1).	DNAJB4 DMD	3.45e-05	4	84	2	28755400
Pubmed	All members of the EPI64 subfamily of TBC/RabGAPs also have GAP activities towards Ras.	TBC1D10B TBC1D10A	3.45e-05	4	84	2	23248241
Pubmed	Pyramidal neuron subtype diversity governs microglia states in the neocortex.	RELN TCERG1L	5.74e-05	5	84	2	35948630
Pubmed	The ephrin signaling pathway regulates morphology and adhesion of mouse granulosa cells in vitro.	EPHA3 EPHA5	5.74e-05	5	84	2	23242526
Pubmed	Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes.	DNAJB1 DNAJB8	5.74e-05	5	84	2	28504929
Pubmed	Expression of ephrinA5 during development and potential involvement in the guidance of the mesostriatal pathway.	EPHA3 EPHA5	5.74e-05	5	84	2	19576892
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	TBC1D10B SLC30A5 PI4KA NISCH DMD WDR13 EPHA3	7.36e-05	421	84	7	36976175
Pubmed	BRCA1 ubiquitinates RPB8 in response to DNA damage.	POLR2A POLR3A	8.59e-05	6	84	2	17283126
Pubmed	A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation.	HDAC6 DNAJB8	8.59e-05	6	84	2	20159555
Pubmed	saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription.	POLR2A PCBP2	8.59e-05	6	84	2	26902284
Pubmed	Area specificity and topography of thalamocortical projections are controlled by ephrin/Eph genes.	EPHA3 EPHA5	8.59e-05	6	84	2	12895420
Pubmed	NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription.	POLR2A CALCOCO1	8.59e-05	6	84	2	29187741
Pubmed	Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta.	GYS1 GYS2	8.59e-05	6	84	2	14680475
Pubmed	Opposing gradients of ephrin-As and EphA7 in the superior colliculus are essential for topographic mapping in the mammalian visual system.	EPHA3 EPHA5	8.59e-05	6	84	2	15996548
Pubmed	Comparative gene expression analysis of the engulfment and cell motility (ELMO) protein family in the mouse brain.	RELN ELMO3	1.20e-04	7	84	2	31521773
Pubmed	Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles.	CHD4 DMD	1.20e-04	7	84	2	32433961
Pubmed	Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver.	GYS1 GYS2	1.20e-04	7	84	2	18165236
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	DNAJB1 GRWD1 RBM12B POLR2A DDX42 PWP2 SLC35F6 CHD4 MCCC1 PCBP2	1.36e-04	989	84	10	36424410
Pubmed	URI Regulates KAP1 Phosphorylation and Transcriptional Repression via PP2A Phosphatase in Prostate Cancer Cells.	POLR2A PCBP2 POLR3A	1.46e-04	42	84	3	27780869
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	DNAJB12 DNAJB1 GRWD1 POLR2A PWP2 DNAJB4 CHD4 PCBP2	1.57e-04	638	84	8	33239621
Pubmed	Mistargeting hippocampal axons by expression of a truncated Eph receptor.	EPHA3 EPHA5	1.60e-04	8	84	2	12124402
Pubmed	Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway.	OBSCN DMD	1.60e-04	8	84	2	28826662
Pubmed	Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor.	DNAJB1 RNF123	1.60e-04	8	84	2	25907116
Pubmed	Transcription repressor activity of spleen tyrosine kinase mediates breast tumor suppression.	HDAC6 SYK	1.60e-04	8	84	2	16288017
Pubmed	HiPLA: High-throughput imaging proximity ligation assay.	DNAJB1 HDAC6 POLR2A	1.91e-04	46	84	3	30419336
Pubmed	Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com.	HDAC6 WDR13	2.05e-04	9	84	2	10391218
Pubmed	Gain of LINC00624 Enhances Liver Cancer Progression by Disrupting the Histone Deacetylase 6/Tripartite Motif Containing 28/Zinc Finger Protein 354C Corepressor Complex.	HDAC6 DDX42	2.05e-04	9	84	2	32869873
Pubmed	Degenerate PCR-based cloning method for Eph receptors and analysis of their expression in the developing murine central nervous system and vasculature.	EPHA3 EPHA5	2.05e-04	9	84	2	11403717
Pubmed	Topographic guidance labels in a sensory projection to the forebrain.	EPHA3 EPHA5	2.05e-04	9	84	2	9883724
Pubmed	Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate.	EPHA3 EPHA5	2.56e-04	10	84	2	25073978
Pubmed	Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues.	CYP1A2 CYP2S1	2.56e-04	10	84	2	15752708
Pubmed	Quantitative assessment of computational models for retinotopic map formation.	EPHA3 EPHA5	2.56e-04	10	84	2	25367067
Pubmed	EphrinA5 Signaling Is Required for the Distinctive Targeting of Raphe Serotonin Neurons in the Forebrain.	EPHA3 EPHA5	2.56e-04	10	84	2	28197551
Pubmed	EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes.	EPHA3 EPHA5	2.56e-04	10	84	2	16547242
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	TBC1D10B RELN HDAC6 RBM12B GYS1 POLR2A DDX42 CHD9 CHD4 PCBP2	2.80e-04	1082	84	10	38697112
Pubmed	Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage.	TBC1D10B RNF123 NISCH OBSCN	2.94e-04	131	84	4	28031328
Pubmed	Bidirectional ephrinB3/EphA4 signaling mediates the segregation of medial ganglionic eminence- and preoptic area-derived interneurons in the deep and superficial migratory stream.	EPHA3 EPHA5	3.13e-04	11	84	2	22171039
Pubmed	Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.	DNAJB1 DNAJB4	3.13e-04	11	84	2	24318877
Pubmed	Selective inhibition of spinal cord neurite outgrowth and cell survival by the Eph family ligand ephrin-A5.	EPHA3 EPHA5	3.13e-04	11	84	2	10559410
Pubmed	Expression of ephrin-A ligands and EphA receptors in the developing mouse tooth and its supporting tissues.	EPHA3 EPHA5	3.13e-04	11	84	2	15517401
Pubmed	Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad.	N4BP2 NISCH CHD4	3.62e-04	57	84	3	14595844
Pubmed	P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity.	HDAC6 DNAJB8	3.75e-04	12	84	2	29519959
Pubmed	EphrinA-EphA receptor interactions in mouse spinal neurulation: implications for neural fold fusion.	EPHA3 EPHA5	3.75e-04	12	84	2	19247962
Pubmed	Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration.	ELMO3 DMD	3.75e-04	12	84	2	36400788
Pubmed	Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.	NCOA6 N4BP2	4.42e-04	13	84	2	17761849
Pubmed	Eph-ephrin A system regulates murine blastocyst attachment and spreading.	EPHA3 EPHA5	4.42e-04	13	84	2	17039519
Pubmed	EphA family gene expression in the developing mouse neocortex: regional patterns reveal intrinsic programs and extrinsic influence.	EPHA3 EPHA5	4.42e-04	13	84	2	12528186
Pubmed	Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue.	EPHA3 EPHA5	5.15e-04	14	84	2	26941654
Pubmed	Differential gene expression in migratory streams of cortical interneurons.	RELN EPHA3	5.15e-04	14	84	2	22103416
Pubmed	A role for the EphA family in the topographic targeting of vomeronasal axons.	EPHA3 EPHA5	5.15e-04	14	84	2	11222144
Pubmed	Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling.	RELN EPHA5	5.93e-04	15	84	2	19759535
Pubmed	Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.	EPHA3 EPHA5	5.93e-04	15	84	2	16380715
Pubmed	In the developing cerebral cortex: axonogenesis, synapse formation, and synaptic plasticity are regulated by SATB2 target genes.	EPHA3 EPHA5	5.93e-04	15	84	2	36028553
Pubmed	The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium.	TMEM115 SLC38A3	5.93e-04	15	84	2	11085536
Pubmed	TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77.	HDAC6 CHD4	5.93e-04	15	84	2	19321449
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	TBC1D10B GRWD1 CALCOCO1 STRN4 CHD9 CHD4 DMD PCBP2	7.61e-04	809	84	8	32129710
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	DNAJB12 DNAJB1 POLR2A DDX42 PWP2 DNAJB4 CHD9 CHD4 POLR3A	7.65e-04	1014	84	9	32416067
Pubmed	Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice.	EPHA3 EPHA5	7.66e-04	17	84	2	12217323
Pubmed	Development of the prethalamus is crucial for thalamocortical projection formation and is regulated by Olig2.	EPHA3 EPHA5	8.60e-04	18	84	2	24803655
Pubmed	Genes, plasticity and mental retardation.	RELN DMD	9.60e-04	19	84	2	18329113
Pubmed	Expression of Ephs and ephrins in developing mouse inner ear.	EPHA3 EPHA5	9.60e-04	19	84	2	12684176
Pubmed	Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone.	DNAJB1 HDAC6	9.60e-04	19	84	2	16919237
Pubmed	Multiple roles of EPH receptors and ephrins in neural development.	EPHA3 EPHA5	1.06e-03	20	84	2	11256076
Pubmed	The ephrins and Eph receptors in neural development.	EPHA3 EPHA5	1.06e-03	20	84	2	9530499
Pubmed	Eph receptors and ephrins: effectors of morphogenesis.	EPHA3 EPHA5	1.06e-03	20	84	2	10207129
Pubmed	The transcription factor neurogenin 2 restricts cell migration from the cortex to the striatum.	EPHA3 EPHA5	1.06e-03	20	84	2	11748150
Pubmed	The Eph family receptors and ligands.	EPHA3 EPHA5	1.06e-03	20	84	2	9576626
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	DNAJB12 DNAJB1 GRWD1 TMEM115 DNAJB4 CHD4 PCBP2	1.07e-03	657	84	7	36180527
Pubmed	The protein tyrosine kinase family of the human genome.	SYK EPHA3 EPHA5	1.09e-03	83	84	3	11114734
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ARFGEF3 DNAJB1 NCOA6 TBC1D10B RADIL N4BP2 PI4KA MCCC1	1.14e-03	861	84	8	36931259
Pubmed	Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.	EPHA3 EPHA5	1.17e-03	21	84	2	9267020
Pubmed	Eph receptors and ephrins demarcate cerebellar lobules before and during their formation.	EPHA3 EPHA5	1.17e-03	21	84	2	10495276
Pubmed	Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways.	TBC1D10B TBC1D10A	1.17e-03	21	84	2	17562788
Pubmed	Developmental expression of Eph and ephrin family genes in mammalian small intestine.	EPHA3 EPHA5	1.17e-03	21	84	2	20112066
Pubmed	Roles of Eph receptors and ephrins in segmental patterning.	EPHA3 EPHA5	1.17e-03	21	84	2	11128993
Pubmed	Eph receptors and ephrins: regulators of guidance and assembly.	EPHA3 EPHA5	1.17e-03	21	84	2	10730216
Pubmed	Noncoding RNA MaIL1 is an integral component of the TLR4-TRIF pathway.	ELMO3 DDX42	1.29e-03	22	84	2	32241891
Pubmed	The imprinted Phlda2 gene regulates extraembryonic energy stores.	GYS1 GYS2	1.29e-03	22	84	2	19884348
Pubmed	Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.	RNF123 RNF115	1.29e-03	22	84	2	24981174
Pubmed	Three proteins define a class of human histone deacetylases related to yeast Hda1p.	HDAC6 CHD4	1.29e-03	22	84	2	10220385
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NCOA6 RADIL CHST15 PI4KA NISCH POLR2A OBSCN STRN4 ITGB4	1.39e-03	1105	84	9	35748872
Pubmed	The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.	GRWD1 PI4KA CHD4 MCCC1	1.40e-03	199	84	4	36688959
Pubmed	Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling.	EPHA3 EPHA5	1.41e-03	23	84	2	19542359
Pubmed	Thalamic afferents influence cortical progenitors via ephrin A5-EphA4 interactions.	EPHA3 EPHA5	1.41e-03	23	84	2	25480914
Pubmed	Sin3a is essential for the genome integrity and viability of pluripotent cells.	DRAM1 CHD4	1.41e-03	23	84	2	22206758
Pubmed	Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways.	NCOA6 DDX42 HERC6 PCBP2	1.46e-03	201	84	4	25192599
Pubmed	Eph receptors and their ephrin ligands are expressed in developing mouse pancreas.	EPHA3 EPHA5	1.54e-03	24	84	2	16446123
Pubmed	Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.	GYS1 PWP2 DNAJB4	1.60e-03	95	84	3	29490077
Pubmed	Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity.	DNAJB1 HDAC6 RNF115	1.65e-03	96	84	3	34599178
Cytoband	3p21.3	TMEM115 DLEC1 SLC38A3	1.78e-04	59	84	3	3p21.3
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJB12 DNAJB1 DNAJB4 DNAJB8	8.49e-06	49	48	4	584
GeneFamily	Fibronectin type III domain containing	OBSCN MYOM2 ITGB4 EPHA3 EPHA5	6.42e-05	160	48	5	555
GeneFamily	Glycosyl transferases group 1 domain containing	GYS1 GYS2	3.06e-04	10	48	2	427
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHA3 EPHA5	6.15e-04	14	48	2	1095
GeneFamily	RNA polymerase subunits	POLR2A POLR3A	2.68e-03	29	48	2	726
GeneFamily	WD repeat domain containing	GRWD1 PWP2 STRN4 WDR13	5.09e-03	262	48	4	362
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MICAL2 PITPNM3 DLEC1 DMD MN1 SMTNL2	1.30e-06	183	84	6	351d575339038bd4a66f408da518c567444208e8
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 RELN OBSCN MYOM2 DMD EPHA5	1.35e-06	184	84	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 RELN OBSCN MYOM2 DMD EPHA5	1.35e-06	184	84	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 RELN OBSCN MYOM2 DMD EPHA5	1.35e-06	184	84	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	RELN DMD CSMD2 EPHA3 EPHA5	1.28e-05	159	84	5	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	wk_20-22-Epithelial-PNS\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	RELN SYPL2 DMD CSMD2 EPHA5	1.92e-05	173	84	5	17b1a6b0318925d5d920f2c0a791745b9587ebef
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C2orf69 RADIL KCNU1 NISCH NACAD	1.97e-05	174	84	5	1d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCell	E16.5-Epithelial-Epithelial_Airway-Neurosecretory\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TCERG1L TMEM45B MICAL2 CYP2S1 AQP3	2.02e-05	175	84	5	38dec78efc99fe23479cba68cfa441e62bd6a08b
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Proximal_secretory_3\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 TMEM45B GLYATL2 AQP3 ITGB4	2.08e-05	176	84	5	8d9d0fb46c418b2067be58aec822e8c2b1561461
ToppCell	3'_v3-GI_small-bowel-Myeloid_Dendritic\|GI_small-bowel / Manually curated celltypes from each tissue	SLAMF8 GLYATL2 CYP2S1 DMD EPHA3	2.51e-05	183	84	5	6109199cf25b28831193a5ed7925b5bf38c6eb43
Disease	Lafora disease (implicated_via_orthology)	GYS1 GYS2	4.23e-05	4	79	2	DOID:3534 (implicated_via_orthology)
Disease	autosomal dominant limb-girdle muscular dystrophy type 1 (implicated_via_orthology)	DNAJB1 DNAJB4	4.23e-05	4	79	2	DOID:0110305 (implicated_via_orthology)
Disease	congenital myopathy 21 (implicated_via_orthology)	DNAJB1 DNAJB4	4.23e-05	4	79	2	DOID:0081353 (implicated_via_orthology)
Disease	lung adenocarcinoma	CYP1A2 ATP8B4 MICAL2 DNAJB4 AQP3	1.07e-04	174	79	5	EFO_0000571
Disease	5-acetylamino-6-amino-3-methyluracil measurement	CYP1A2 SLC38A3	3.83e-04	11	79	2	EFO_0800951
Disease	non-melanoma skin carcinoma	MMP24 NCOA6 ATP8B4 DCLRE1B CSMD2	7.38e-04	265	79	5	EFO_0009260
Disease	Feeding difficulties	POLR2A MN1	1.05e-03	18	79	2	C0232466
Disease	blood chromium measurement	TCERG1L MICAL2	2.21e-03	26	79	2	EFO_0007579
Disease	Glycogen Storage Disease	GYS1 GYS2	2.38e-03	27	79	2	C0017919

Protein segments in the cluster

Peptide	Gene	Start	Entry
FDPGTVMRFSCEAGH	CSMD2	2851	Q7Z408
MFGAPEHNTDFGAFK	C2orf69	171	Q8N8R5
FDNMGADSFHEPSAF	AZIN1	381	O14977
FLGEASIMGQFDHPN	EPHA5	721	P54756
LSGFGCFMQEHVADP	GYS2	531	P54840
PMATGDDCGHIRFFS	CASTOR2	216	A6NHX0
LFTMHSNGIFGIFPN	ATP8B4	1036	Q8TF62
GQGPMFLDADFVAFT	DMD	901	P11532
DANHCPGSVMFLFEG	DCLRE1B	96	Q9H816
GDPHAMFAEFFGGRN	DNAJB1	96	P25685
AGFGEFPAFMEAFSS	DNAJB8	136	Q8NHS0
FDFGKHNMGSFPEGR	RBM12B	896	Q8IXT5
GAMCFGQHFPESSDE	CYP1A2	201	P05177
MRSAGFGAAGEHFFQ	RADIL	681	Q96JH8
PESGIFGFMINFSAF	DRAM1	51	Q8N682
MIFFASGFHGDSSPF	MMP24	221	Q9Y5R2
PIFSFAGHMGEGFAL	GRWD1	206	Q9BQ67
GFGMSQVVGHLDFFP	PNLIP	231	P16233
MADSANHLPFFFGNI	SYK	6	P43405
QFPFMGSRSIDDFHQ	DPYS	71	Q14117
MLEGTFDGHGVFFSN	CYP2S1	106	Q96SQ9
PGSSFAHFGFDEQLM	DDX42	251	Q86XP3
PESGGVSSEFFHCMF	HERC6	711	Q8IVU3
IIHIDFGFMFESSPG	PI4KA	1971	P42356
FGDAHSAPMGLRNFV	KCNU1	721	A8MYU2
VGMFFEAGLNSTFPA	OVOS2	1091	Q6IE36
HLVNGRMDFAFPGST	ITGB4	1441	P16144
GSSAFGFGIMSDHQF	RELN	106	P78509
FPMTHGNTGFSGIES	PCBP2	256	Q15366
THDGFGFMLAFGDMA	TM7SF2	251	O76062
EGPMFSHTFGDTEAQ	OBSCN	4896	Q5VST9
FSGHGMSFNAPFSGA	NCOA6	846	Q14686
EDFPFVFHSMPEFGA	OSGIN2	276	Q9Y236
FPDPVDSGTQMGHFN	CHD9	361	Q3L8U1
EIDGDPFSAFGFSMN	DNAJB4	126	Q9UDY4
MMHSPGFDGNSSLSF	ARFGEF3	711	Q5TH69
PCEGMSRHATFENFG	CACNA1I	1651	Q9P0X4
ADISPEDLFNMFFGG	DNAJB12	196	Q9NXW2
EDLFNMFFGGGFPSS	DNAJB12	201	Q9NXW2
FCMDVDQHFSGTFGP	A3GALT2	196	U3KPV4
QDFSPMFFGQDQSFH	ELMO3	426	Q96BJ8
DFLGEASIMGQFDHP	EPHA3	666	P29320
HPGCGFLSENMEFAE	MCCC1	126	Q96RQ3
MDFSPSSELGFHFVA	KCNMB3	1	Q9NPA1
HEMRGTADFFAFSFG	KLB	361	Q86Z14
HGTFFPMGDEGASSQ	HDAC6	676	Q9UBN7
LSGFGCFMEEHIADP	GYS1	531	P13807
FMFNIADGGFTELHS	CHD4	1696	Q14839
SMLSHGKGAAFFPHF	DLEC1	1176	Q9Y238
GKGAAFFPHFSQGML	DLEC1	1181	Q9Y238
MDGHFFFSTQDPFTF	CALCOCO1	676	Q9P1Z2
KAAHLASMFGHGDFP	MICAL2	871	O94851
FFLSHGCPGMATFRE	PRR14L	1766	Q5THK1
SGHFDMFSPSDSEGQ	MN1	241	Q10571
SGCMTQLFVEHFFGG	OR4C5	116	Q8NGB2
HLMGDFSAPAEFFVT	SYPL2	106	Q5VXT5
GHLDHTMFFQDFRPF	RNF115	76	Q9Y4L5
EPHFTDFEGKTSFGM	SLC38A3	56	Q99624
AQFSDFLGSMGPAQF	RIMS4	91	Q9H426
GLTPTEFFFHTMAGR	POLR3A	841	O14802
AGDDHGSVFSFLFDM	WDR13	321	Q9H1Z4
FFASDDSFAMIRGGH	OXCT2	376	Q9BYC2
PSGHLDMINGFFDQF	AQP3	151	Q92482
FHYGGFPSNPSLMDS	CHST15	111	Q7LFX5
GDDRVFFFNPTMHLS	TCERG1L	351	Q5VWI1
MANFKGHALPGSFFL	TMEM45B	1	Q96B21
GHFNSMVALAYSPDG	PWP2	371	Q15269
HGDRTGSLFAFMPEF	RNF123	851	Q5XPI4
LTPTEFFFHAMGGRE	POLR2A	831	P24928
FFFHAMGGREGLIDT	POLR2A	836	P24928
GDMADHFAFATFFPE	TMEM115	216	Q12893
FCFPHGDLTEFGFLM	NISCH	761	Q9Y2I1
SDGMAFCALVHSFFP	SMTNL2	381	Q2TAL5
FPFHEMFAARGGHGQ	TBC1D10B	411	Q4KMP7
DFGMEPHSLFTDGQV	SLAMF8	171	Q9P0V8
FPQGMIFFSDGLVHD	PITPNM3	801	Q9BZ71
HPFLQAVGMFLGEFS	SLC35F6	46	Q8N357
GTPLYNFMGDAFQHS	SLC30A5	381	Q8TAD4
AVDPNGAFLMSGSHD	STRN4	686	Q9NRL3
FFNFLEHRFGPSDAM	TSNAXIP1	421	Q2TAA8
QFPFHEMFVSRGGHG	TBC1D10A	161	Q9BXI6
MGNFRGHALPGTFFF	TMEM45A	1	Q9NWC5
GNFSNMFLDASHAGL	GLYATL2	161	Q8WU03
EGHFFDLDFLANDPM	NACAD	291	O15069
MIPAFDLFQGNHGFV	N4BP2	366	Q86UW6
MAGENFATPFHGHVG	N6AMT1	1	Q9Y5N5
MFFGEGQASLSFSHL	MYOM2	331	P54296