Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondipeptidyl-peptidase activity

DPP4 FAP

5.04e-0512182GO:0008239
GeneOntologyBiologicalProcessnegative regulation of extracellular matrix disassembly

DPP4 FAP

3.22e-0510182GO:0010716
GeneOntologyCellularComponentlamellipodium membrane

DPP4 FAP

1.60e-0422182GO:0031258
MousePhenoincreased lung tumor incidence

CUL9 MCM4 TSC2

3.54e-0510793MP:0008014
MousePhenoincreased respiratory system tumor incidence

CUL9 MCM4 TSC2

3.54e-0510793MP:0010298
MousePhenoincreased liver tumor incidence

CUL9 MCM4 TSC2

3.95e-0511193MP:0008019
MousePhenoincreased hepatobiliary system tumor incidence

CUL9 MCM4 TSC2

3.95e-0511193MP:0010297
MousePhenoabnormal lung morphology

CUL9 DPP4 MCM4 TSC2 FBXW7

5.14e-0576795MP:0001175
MousePhenoabnormal respiratory system morphology

CUL9 DPP4 MCM4 TSC2 FBXW7

2.08e-04102795MP:0002132
MousePhenothick pulmonary interalveolar septum

DPP4 FBXW7

3.44e-044492MP:0001179
MousePhenoincreased malignant tumor incidence

CUL9 MCM4 TSC2

3.75e-0423793MP:0002018
MousePhenohemorrhage

DPP4 TSC2 DZIP1L FBXW7

5.25e-0466494MP:0001914
MousePhenoabnormal pulmonary interalveolar septum morphology

DPP4 FBXW7

5.38e-045592MP:0010900
MousePhenoeyelids open at birth

LIMK2 FBXW7

5.98e-045892MP:0001302
MousePhenoabnormal blood circulation

DPP4 TSC2 DZIP1L FBXW7

1.31e-0384594MP:0002128
MousePhenoincreased classified tumor incidence

CUL9 MCM4 TSC2

1.49e-0338193MP:0010273
MousePhenoabnormal classified tumor incidence

CUL9 MCM4 TSC2

1.53e-0338493MP:0020188
MousePhenointernal hemorrhage

DPP4 TSC2 FBXW7

1.56e-0338793MP:0001634
MousePhenoincreased organ/body region tumor incidence

CUL9 MCM4 TSC2

1.66e-0339593MP:0010274
MousePhenoabnormal organ/body region tumor incidence

CUL9 MCM4 TSC2

1.73e-0340193MP:0013152
MousePhenodilated renal tubule

LIMK2 DZIP1L

1.80e-0310192MP:0002705
MousePhenoincreased sarcoma incidence

CUL9 TSC2

1.84e-0310292MP:0002032
MousePhenoabnormal adenoma incidence

CUL9 TSC2

2.13e-0311092MP:0020189
MousePhenoincreased adenoma incidence

CUL9 TSC2

2.13e-0311092MP:0010383
DomainPept_S9_AS

DPP4 FAP

5.26e-064182IPR002471
DomainPRO_ENDOPEP_SER

DPP4 FAP

8.76e-065182PS00708
DomainPeptidase_S9B_N

DPP4 FAP

1.31e-056182IPR002469
Domain-

DPP4 FAP

1.31e-0561822.140.10.30
DomainDPPIV_N

DPP4 FAP

1.31e-056182PF00930
DomainPeptidase_S9

DPP4 FAP

4.80e-0511182PF00326
DomainPeptidase_S9

DPP4 FAP

4.80e-0511182IPR001375
DomainZINC_FINGER_C2H2_2

ZNF805 ZNF12 ZNF525 DZIP1L ZNF28 ZNF468

6.05e-05775186PS50157
DomainZINC_FINGER_C2H2_1

ZNF805 ZNF12 ZNF525 DZIP1L ZNF28 ZNF468

6.14e-05777186PS00028
DomainZnf_C2H2

ZNF805 ZNF12 ZNF525 DZIP1L ZNF28 ZNF468

7.48e-05805186IPR007087
DomainZnF_C2H2

ZNF805 ZNF12 ZNF525 DZIP1L ZNF28 ZNF468

7.64e-05808186SM00355
DomainKRAB

ZNF805 ZNF12 ZNF28 ZNF468

3.28e-04358184PS50805
DomainKRAB

ZNF805 ZNF12 ZNF28 ZNF468

3.28e-04358184PF01352
DomainKRAB

ZNF805 ZNF12 ZNF28 ZNF468

3.68e-04369184SM00349
DomainKRAB

ZNF805 ZNF12 ZNF28 ZNF468

3.72e-04370184IPR001909
Domainzf-C2H2

ZNF805 ZNF12 ZNF525 ZNF28 ZNF468

3.97e-04693185PF00096
DomainZnf_C2H2-like

ZNF805 ZNF12 DZIP1L ZNF28 ZNF468

7.48e-04796185IPR015880
Domain-

CUL9 TSC2 MROH5

1.18e-032221831.25.10.10
DomainARM-like

CUL9 TSC2 MROH5

2.08e-03270183IPR011989
Domainzf-C2H2_6

ZNF805 ZNF12 ZNF468

3.18e-03314183PF13912
Domain-

ZNF805 ZNF12 ZNF28 ZNF468

3.53e-036791843.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

ZNF805 ZNF12 ZNF28 ZNF468

3.81e-03694184IPR013087
DomainARM-type_fold

CUL9 TSC2 MROH5

3.95e-03339183IPR016024
Domain-

DPP4 FAP

5.76e-031191823.40.50.1820
DomainAB_hydrolase

DPP4 FAP

5.76e-03119182IPR029058
Pubmed

Co-expression of the homologous proteases fibroblast activation protein and dipeptidyl peptidase-IV in the adult human Langerhans islets.

DPP4 FAP

2.53e-07218225361590
Pubmed

Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblasts.

DPP4 FAP

2.53e-07218220155839
Pubmed

Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers.

DPP4 FAP

2.53e-0721827911242
Pubmed

Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours.

DPP4 FAP

2.53e-07218219817894
Pubmed

Plasma seprase and DPP4 levels as markers of disease and prognosis in cancer.

DPP4 FAP

2.53e-07218222674411
Pubmed

The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices.

DPP4 FAP

2.53e-07218216651416
Pubmed

Extra-enzymatic roles of DPIV and FAP in cell adhesion and migration on collagen and fibronectin.

DPP4 FAP

2.53e-07218216700525
Pubmed

Coupled expression of dipeptidyl peptidase-IV and fibroblast activation protein-α in transformed astrocytic cells.

DPP4 FAP

2.53e-07218221526345
Pubmed

Upregulated expression and activation of membrane‑associated proteases in esophageal squamous cell carcinoma.

DPP4 FAP

2.53e-07218224789592
Pubmed

Characterization of dedifferentiating human mature adipocytes from the visceral and subcutaneous fat compartments: fibroblast-activation protein alpha and dipeptidyl peptidase 4 as major components of matrix remodeling.

DPP4 FAP

2.53e-07218225816202
Pubmed

Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts.

DPP4 FAP

2.53e-07218210593948
Pubmed

Circulating fibroblast activation protein and dipeptidyl peptidase 4 in rheumatoid arthritis and systemic sclerosis.

DPP4 FAP

2.53e-07218227990763
Pubmed

Targeted disruption of mouse fibroblast activation protein.

DPP4 FAP

2.53e-07218210629066
Pubmed

Heterogeneity of molecular forms of dipeptidyl peptidase-IV and fibroblast activation protein in human glioblastomas.

DPP4 FAP

2.53e-07218228452380
Pubmed

Unravelling the immunological roles of dipeptidyl peptidase 4 (DPP4) activity and/or structure homologue (DASH) proteins.

DPP4 FAP

2.53e-07218226671446
Pubmed

Regulation of fibroblast migration on collagenous matrix by a cell surface peptidase complex.

DPP4 FAP

2.53e-07218212023964
Pubmed

Expression of dipeptidyl peptidase-IV activity and/or structure homologs in human meningiomas.

DPP4 FAP

1.52e-06418220043068
Pubmed

Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver.

DPP4 FAP

2.53e-06518223704821
Pubmed

Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-α.

DPP4 FAP

9.09e-06918221314817
Pubmed

The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia.

DPP4 FAP

1.66e-051218226209915
Pubmed

Multiple genes encoding zinc finger domains are expressed in human T cells.

ZNF12 ZNF28

1.17e-04311822288909
Pubmed

Tumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as the  receptor protein of CRL2Prame complex.

CUL9 FBXW7

2.81e-044818233504946
Cytoband19q13.41

ZNF28 ZNF468

4.28e-047818219q13.41
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF805 ZNF525 ZNF28 ZNF468

1.03e-031192184chr19q13
CytobandEnsembl 112 genes in cytogenetic band chr2q24

DPP4 FAP

1.13e-03127182chr2q24
GeneFamilyCD molecules|DASH family

DPP4 FAP

1.54e-0571621205
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF805 ZNF12 ZNF525 ZNF28 ZNF468

2.95e-0471816528
Drug2i3z

DPP4 FAP

5.90e-072182CID011987865
Drug2gbi

DPP4 FAP

5.90e-072182CID006914643
Drugglycylproline 4-nitroanilide

DPP4 FAP

3.54e-064182ctd:C042892
Drugalanylproline-4-nitroanilide

DPP4 FAP

5.89e-065182ctd:C083013
DrugClomipramine hydrochloride [17321-77-6]; Down 200; 11.4uM; PC3; HT_HG-U133A

DPP4 MCM4 LIMK2 FBXW7

1.37e-051921844487_DN
Drugdiguanylic acid

DPP4 FAP

2.12e-059182CID000167640
DrugSureCN475872

DPP4 FAP

2.12e-059182CID011163584
DrugX1043

DPP4 FAP

2.65e-0510182CID011235728
Drugdiphenyl phosphonate

DPP4 FAP

1.23e-0421182CID006327546
DrugValboroPro

DPP4 FAP

2.20e-0428182CID006918572
DrugAC1Q5TX2

DPP4 FAP

2.89e-0432182CID000051716
DrugV3 loop peptide

DPP4 FBXW7

3.26e-0434182CID000455672
DrugPromethazine hydrochloride [58-33-3]; Down 200; 12.4uM; PC3; HT_HG-U133A

DPP4 MCM4 LIMK2

4.19e-041891836717_DN
DrugSalbutamol [18559-94-9]; Down 200; 16.8uM; PC3; HT_HG-U133A

CUL9 DPP4 LIMK2

4.32e-041911837376_DN
DrugSulfamethoxazole [723-46-6]; Down 200; 15.8uM; PC3; HT_HG-U133A

MCM4 LIMK2 FBXW7

4.46e-041931833667_DN
Drugretinoic acid; Down 200; 1uM; MCF7; HT_HG-U133A

MCM4 LIMK2 ZNF468

4.46e-041931836931_DN
DrugDanazol [17230-88-5]; Down 200; 11.8uM; PC3; HG-U133A

DPP4 MCM4 ZNF468

4.52e-041941831954_DN
DrugSulfathiazole [72-14-0]; Up 200; 15.6uM; PC3; HG-U133A

MCM4 LIMK2 ZNF468

4.59e-041951831883_UP
Drug17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A

LIMK2 TMEM62 FBXW7

4.59e-041951831650_UP
DrugBetulinic acid [472-15-1]; Down 200; 8.8uM; PC3; HT_HG-U133A

MCM4 LIMK2 FBXW7

4.66e-041961834101_DN
DrugTriflupromazine hydrochloride [1098-60-8]; Down 200; 10.2uM; MCF7; HT_HG-U133A

LIMK2 TMEM62 FBXW7

4.66e-041961831691_DN
DrugHyoscyamine (L) [101-31-5]; Down 200; 13.8uM; PC3; HT_HG-U133A

CUL9 DPP4 MCM4

4.66e-041961832108_DN
DrugTriprolidine hydrochloride [550-70-9]; Up 200; 12.8uM; MCF7; HT_HG-U133A

CUL9 LIMK2 TMEM62

4.66e-041961837408_UP
DrugBenzethonium chloride [121-54-0]; Down 200; 9uM; MCF7; HT_HG-U133A

MCM4 TMEM62 ZNF468

4.73e-041971837207_DN
DrugGallamine triethiodide [65-29-2]; Up 200; 4.4uM; PC3; HT_HG-U133A

MCM4 LIMK2 FBXW7

4.73e-041971832059_UP
DrugCefotiam hydrochloride; Down 200; 7.2uM; MCF7; HT_HG-U133A

CUL9 LIMK2 FBXW7

4.73e-041971835361_DN
DrugAlfadolone acetate [23930-37-2]; Up 200; 10.2uM; MCF7; HT_HG-U133A

CUL9 DPP4 FBXW7

4.73e-041971836506_UP
DrugEli

DPP4 FBXW7

4.75e-0441182CID009549220
DrugPentolinium bitartrate [52-62-0]; Down 200; 7.4uM; MCF7; HT_HG-U133A

CUL9 ZNF468 FBXW7

4.80e-041981832305_DN
DrugCyclobenzaprine hydrochloride [6202-23-9]; Down 200; 12.8uM; PC3; HT_HG-U133A

DPP4 LIMK2 FBXW7

4.80e-041981834252_DN
Drugfluphenazine dihydrochloride; Down 200; 10uM; PC3; HT_HG-U133A

CUL9 LIMK2 TMEM62

4.80e-041981831237_DN
DrugFlunarizine dihydrochloride [30484-77-6]; Down 200; 8.4uM; PC3; HT_HG-U133A

CUL9 LIMK2 TMEM62

4.80e-041981837252_DN
DrugIsocarboxazid [59-63-2]; Up 200; 17.2uM; PC3; HT_HG-U133A

DPP4 LIMK2 FBXW7

4.80e-041981837383_UP
DrugCanavanine sulfate monohydrate (L,+) [206996-57-8]; Up 200; 13.6uM; MCF7; HT_HG-U133A

CUL9 DPP4 FBXW7

4.80e-041981834782_UP
DrugSulfamethoxazole [723-46-6]; Up 200; 15.8uM; PC3; HT_HG-U133A

DPP4 LIMK2 FBXW7

4.87e-041991837366_UP
DrugDextromethorphan hydrobromide monohydrate [6700-34-1]; Down 200; 10.8uM; PC3; HT_HG-U133A

DPP4 LIMK2 TMEM62

4.87e-041991836300_DN
DrugOleandomycin phosphate [7060-74-4]; Down 200; 5uM; PC3; HT_HG-U133A

MCM4 LIMK2 FBXW7

4.87e-041991834615_DN
DrugDiclofenac sodium [15307-79-6]; Down 200; 12.6uM; MCF7; HT_HG-U133A

TSC2 LIMK2 ZNF468

4.87e-041991837215_DN
DrugMeclocycline sulfosalicylate [73816-42-9]; Up 200; 5.8uM; MCF7; HT_HG-U133A

KLHL11 CUL9 TMEM62

4.87e-041991834982_UP
DrugPHA-00816795 [212631-79-3]; Down 200; 10uM; PC3; HT_HG-U133A

MCM4 TMEM62 FBXW7

4.87e-041991837072_DN
DrugKetotifen fumarate [34580-14-8]; Down 200; 9.4uM; PC3; HT_HG-U133A

CUL9 DPP4 TMEM62

4.94e-042001835842_DN
DrugDyclonine hydrochloride [536-43-6]; Down 200; 12.2uM; PC3; HT_HG-U133A

CUL9 TSC2 LIMK2

4.94e-042001837261_DN
DrugD-6069

DPP4 FAP

4.99e-0442182CID000181664
Drugsitagliptin

DPP4 FAP

5.48e-0444182CID004369359
DrugAC1Q6T4Q

DPP4 FAP

5.73e-0445182CID000000516
DrugI11-0029

DPP4 FAP

5.73e-0445182CID005251896
DrugM-VAC protocol

CUL9 TSC2

5.99e-0446182ctd:C044361
DrugLysylproline

DPP4 FAP

6.52e-0448182CID000171204
Diseaseesophagus squamous cell carcinoma (is_marker_for)

DPP4 FAP

8.24e-0474172DOID:3748 (is_marker_for)
Diseasevascular endothelial function measurement

ZNF28 ZNF468

1.47e-0399172EFO_0803369
Diseaseeosinophil percentage of leukocytes

MCM4 LIMK2 FBXW7

8.40e-03746173EFO_0007991
Diseaseeosinophil count

MCM4 FAP LIMK2 FBXW7

9.04e-031488174EFO_0004842

Protein segments in the cluster

PeptideGeneStartEntry
IMSSAIAYLCGHLHT

TMEM62

246

Q0P6H9
LLMQTGTHSYHTCHL

DZIP1L

156

Q8IYY4
CHTTHSMALIHNRSL

MCM4

331

P33991
YLHSMCIIHRDLNSH

LIMK2

441

P53671
GIASSTAHQHIYTHM

DPP4

741

P27487
LHHLSIPGSHDTMTY

PLCXD1

36

Q9NUJ7
HLSNCVAIHSLAHMY

KLHL11

201

Q9NVR0
TLYGHTSTVRCMHLH

FBXW7

456

Q969H0
SNGSTGSHYITLHMH

CUL9

1196

Q8IWT3
FHYVTTMSHHHCVLL

OR1L8

131

Q8NGR8
IHLSQALSYLHSHSC

MROH5

1236

Q6ZUA9
SQMSSLTYHHRLHTG

ZNF525

281

Q8N782
LSGLSTNHLYTHMTH

FAP

736

Q12884
QMSSLVYHHRLHSGE

ZNF28

646

P17035
SQMSNLVYHHRLHSG

ZNF28

701

P17035
QMSYLTIHHRIHSGE

ZNF12

616

P17014
QMSSLVYHHRLHSGE

ZNF468

506

Q5VIY5
SKSTYLLQHHMVHTG

ZNF805

241

Q5CZA5
THLGHSAIYNMCHLM

TSC2

266

P49815