Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	CNGB3 TRPM2 RYR1 RYR3	2.64e-06	33	59	4	GO:0005217
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	HTR3A CNGB3 TRPM2 SHROOM2 RYR1 RYR3	3.54e-06	140	59	6	GO:0099094
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	TRPM2 RYR1 RYR3	1.94e-05	18	59	3	GO:0015278
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	HTR3A CNGB3 TRPM2 SHROOM2 RYR1 RYR3	2.22e-05	193	59	6	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	HTR3A CNGB3 TRPM2 SHROOM2 RYR1 RYR3	2.49e-05	197	59	6	GO:0022834
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR3	5.13e-05	4	59	2	GO:0005219
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	TRPM2 RYR1 RYR3	1.04e-04	31	59	3	GO:0099604
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR3	1.28e-04	6	59	2	GO:0048763
GeneOntologyMolecularFunction	gated channel activity	HTR3A CNGB3 TRPM2 SHROOM2 RYR1 RYR3	4.47e-04	334	59	6	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation channel activity	HTR3A CNGB3 TRPM2 SHROOM2 RYR1 RYR3	5.15e-04	343	59	6	GO:0005261
GeneOntologyMolecularFunction	diacylglycerol-dependent serine/threonine kinase activity	PKN2 PRKCQ	1.00e-03	16	59	2	GO:0004697
GeneOntologyMolecularFunction	monoatomic ion channel activity	HTR3A CNGB3 TRPM2 SHROOM2 RYR1 RYR3	2.30e-03	459	59	6	GO:0005216
GeneOntologyBiologicalProcess	cellular response to purine-containing compound	TRPM2 RYR1 RYR3	9.19e-06	14	62	3	GO:0071415
HumanPheno	Nemaline bodies	TNNT1 RYR1 RYR3	4.82e-05	19	20	3	HP:0003798
HumanPheno	Difficulty walking and climbing stairs	SPEG TNNT1 RYR1 RYR3	4.82e-05	54	20	4	HP:0007019
HumanPheno	Difficulty running	SPEG TNNT1 RYR1 RYR3	4.82e-05	54	20	4	HP:0009046
HumanPheno	Difficulty walking	SPEG TNNT1 RYR1 RYR3	4.82e-05	54	20	4	HP:0002355
HumanPheno	Type 1 muscle fiber predominance	SPEG TNNT1 RYR1 RYR3	1.07e-04	66	20	4	HP:0003803
HumanPheno	Gowers sign	SPEG TNNT1 RYR1 RYR3	2.05e-04	78	20	4	HP:0003391
HumanPheno	Abnormality of the shoulder girdle musculature	SPEG REV3L TNNT1 RYR1 RYR3	2.18e-04	149	20	5	HP:0001435
HumanPheno	Muscle fiber cytoplasmatic inclusion bodies	TNNT1 RYR1 RYR3	2.39e-04	32	20	3	HP:0100303
HumanPheno	Abnormal muscle fiber-type distribution	SPEG TNNT1 RYR1 RYR3	2.60e-04	83	20	4	HP:0033684
HumanPheno	Difficulty climbing stairs	SPEG TNNT1 RYR1 RYR3	2.99e-04	86	20	4	HP:0003551
Domain	Ryanrecept_TM4-6	RYR1 RYR3	3.04e-05	3	60	2	IPR009460
Domain	RyR	RYR1 RYR3	3.04e-05	3	60	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR3	3.04e-05	3	60	2	IPR003032
Domain	RR_TM4-6	RYR1 RYR3	3.04e-05	3	60	2	PF06459
Domain	Ryan_recept	RYR1 RYR3	3.04e-05	3	60	2	IPR013333
Domain	RIH_assoc	RYR1 RYR3	1.51e-04	6	60	2	PF08454
Domain	RIH_assoc-dom	RYR1 RYR3	1.51e-04	6	60	2	IPR013662
Domain	RIH_dom	RYR1 RYR3	1.51e-04	6	60	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR3	1.51e-04	6	60	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR3	1.51e-04	6	60	2	IPR015925
Domain	-	RYR1 RYR3	1.51e-04	6	60	2	1.25.10.30
Domain	RYDR_ITPR	RYR1 RYR3	1.51e-04	6	60	2	PF01365
Domain	Ins145_P3_rec	RYR1 RYR3	1.51e-04	6	60	2	PF08709
Domain	Pkinase_C	MAST1 PKN2 PRKCQ	3.31e-04	42	60	3	PF00433
Domain	MIR	RYR1 RYR3	4.49e-04	10	60	2	PS50919
Domain	MIR	RYR1 RYR3	4.49e-04	10	60	2	PF02815
Domain	MIR	RYR1 RYR3	4.49e-04	10	60	2	SM00472
Domain	MIR_motif	RYR1 RYR3	4.49e-04	10	60	2	IPR016093
Domain	Ion_trans_dom	CNGB3 TRPM2 RYR1 RYR3	4.93e-04	114	60	4	IPR005821
Domain	Ion_trans	CNGB3 TRPM2 RYR1 RYR3	4.93e-04	114	60	4	PF00520
Domain	AGC-kinase_C	MAST1 PKN2 PRKCQ	7.74e-04	56	60	3	IPR000961
Domain	AGC_KINASE_CTER	MAST1 PKN2 PRKCQ	7.74e-04	56	60	3	PS51285
Domain	S_TK_X	MAST1 PKN2 PRKCQ	7.74e-04	56	60	3	SM00133
Domain	PLAC	ADAMTS10 ADAMTS6	9.01e-04	14	60	2	PF08686
Domain	TSP_1	ADAMTS10 ADAMTS6 C7	1.09e-03	63	60	3	PF00090
Domain	PDZ	MAST1 SHROOM2 RGS3 AHNAK2	1.09e-03	141	60	4	PF00595
Domain	TSP1	ADAMTS10 ADAMTS6 C7	1.19e-03	65	60	3	SM00209
Domain	TSP1_rpt	ADAMTS10 ADAMTS6 C7	1.19e-03	65	60	3	IPR000884
Domain	TSP1	ADAMTS10 ADAMTS6 C7	1.19e-03	65	60	3	PS50092
Domain	PDZ	MAST1 SHROOM2 RGS3 AHNAK2	1.31e-03	148	60	4	SM00228
Domain	-	MAST1 SHROOM2 RGS3 AHNAK2	1.37e-03	150	60	4	2.30.42.10
Domain	PDZ	MAST1 SHROOM2 RGS3 AHNAK2	1.41e-03	151	60	4	PS50106
Domain	PDZ	MAST1 SHROOM2 RGS3 AHNAK2	1.44e-03	152	60	4	IPR001478
Domain	PLAC	ADAMTS10 ADAMTS6	1.68e-03	19	60	2	PS50900
Domain	PLAC	ADAMTS10 ADAMTS6	1.68e-03	19	60	2	IPR010909
Domain	ADAM_spacer1	ADAMTS10 ADAMTS6	2.46e-03	23	60	2	IPR010294
Domain	ADAM_spacer1	ADAMTS10 ADAMTS6	2.46e-03	23	60	2	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS10 ADAMTS6	2.68e-03	24	60	2	IPR013273
Domain	Ser/Thr_kinase_AS	SPEG MAST1 PKN2 PRKCQ BRSK1	5.73e-03	357	60	5	IPR008271
Domain	S_TKc	SPEG MAST1 PKN2 PRKCQ BRSK1	5.87e-03	359	60	5	SM00220
Domain	PROTEIN_KINASE_ST	SPEG MAST1 PKN2 PRKCQ BRSK1	6.07e-03	362	60	5	PS00108
Domain	Pkinase_C	PKN2 PRKCQ	6.29e-03	37	60	2	IPR017892
Domain	Peptidase_M12B_N	ADAMTS10 ADAMTS6	6.97e-03	39	60	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS10 ADAMTS6	6.97e-03	39	60	2	PF01562
Domain	DISINTEGRIN_1	ADAMTS10 ADAMTS6	7.32e-03	40	60	2	PS00427
Pubmed	Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.	RYR1 RYR3	3.33e-06	2	64	2	15894801
Pubmed	ADAMTS-10 and -6 differentially regulate cell-cell junctions and focal adhesions.	ADAMTS10 ADAMTS6	3.33e-06	2	64	2	27779234
Pubmed	Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors.	RYR1 RYR3	3.33e-06	2	64	2	9799464
Pubmed	Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3.	RYR1 RYR3	3.33e-06	2	64	2	9817784
Pubmed	Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene.	RYR1 RYR3	3.33e-06	2	64	2	12565913
Pubmed	Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors.	RYR1 RYR3	3.33e-06	2	64	2	9489997
Pubmed	Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.	RYR1 RYR3	3.33e-06	2	64	2	9192302
Pubmed	The block of ryanodine receptors selectively inhibits fetal myoblast differentiation.	RYR1 RYR3	3.33e-06	2	64	2	12640042
Pubmed	Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.	RYR1 RYR3	3.33e-06	2	64	2	7556644
Pubmed	Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion.	RYR1 RYR3	3.33e-06	2	64	2	14592949
Pubmed	Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development.	RYR1 RYR3	3.33e-06	2	64	2	17118445
Pubmed	RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.	RYR1 RYR3	3.33e-06	2	64	2	11500519
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	STARD9 ZNF862 MAST1 SHROOM2 RGS3 CRAMP1	4.59e-06	233	64	6	37704626
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR3	9.99e-06	3	64	2	9242641
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR3	9.99e-06	3	64	2	18403125
Pubmed	Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor.	RYR1 RYR3	9.99e-06	3	64	2	11171121
Pubmed	Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.	RYR1 RYR3	9.99e-06	3	64	2	18313230
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR3	9.99e-06	3	64	2	22948152
Pubmed	Frontrunners of T cell activation: Initial, localized Ca2+ signals mediated by NAADP and the type 1 ryanodine receptor.	TRPM2 RYR1	9.99e-06	3	64	2	26462735
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR3	9.99e-06	3	64	2	10788707
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR3	9.99e-06	3	64	2	18434746
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR3	9.99e-06	3	64	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR3	9.99e-06	3	64	2	7621815
Pubmed	The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5.	SUPT20HL1 SUPT20HL2	9.99e-06	3	64	2	24220028
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR3	9.99e-06	3	64	2	9204703
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR3	9.99e-06	3	64	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR3	9.99e-06	3	64	2	11159936
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR3	9.99e-06	3	64	2	7876312
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR3	9.99e-06	3	64	2	21881589
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR3	9.99e-06	3	64	2	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR3	9.99e-06	3	64	2	7959768
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR3	9.99e-06	3	64	2	12213830
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR3	9.99e-06	3	64	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR3	9.99e-06	3	64	2	7635066
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	KMT2B HIRIP3 RECQL5 CIZ1 SNAPC4 UBN2 CCDC86 PRDM2	1.56e-05	608	64	8	36089195
Pubmed	Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.	RYR1 RYR3	2.00e-05	4	64	2	22100703
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR3	2.00e-05	4	64	2	9384575
Pubmed	Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins.	PRKCQ CBL	2.00e-05	4	64	2	10358153
Pubmed	Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.	CBL GAB1	2.00e-05	4	64	2	9242692
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR3	2.00e-05	4	64	2	18206662
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR3	2.00e-05	4	64	2	9607712
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR3	2.00e-05	4	64	2	23482488
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR3	2.00e-05	4	64	2	23413940
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KMT2B SPEG ZNF398 ATG2A REV3L SNAPC4 CRAMP1 RYR1 GAREM1 AHNAK2	3.21e-05	1105	64	10	35748872
Pubmed	Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.	CBL GAB1	3.32e-05	5	64	2	12486104
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR3	3.32e-05	5	64	2	19011160
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR3	3.32e-05	5	64	2	23918386
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZNF469 KRBA1 BRSK1 CAPN10	4.67e-05	107	64	4	11347906
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR3	4.98e-05	6	64	2	19549818
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR3	4.98e-05	6	64	2	19009018
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR1 RYR3	4.98e-05	6	64	2	26025922
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 RYR3	4.98e-05	6	64	2	23463619
Pubmed	Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers.	RYR1 RYR3	4.98e-05	6	64	2	10444070
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 RYR3	4.98e-05	6	64	2	16844763
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR1 RYR3	4.98e-05	6	64	2	14592808
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 RYR3	4.98e-05	6	64	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 RYR3	4.98e-05	6	64	2	25966694
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 RYR3	6.96e-05	7	64	2	11860456
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR1 RYR3	6.96e-05	7	64	2	20962236
Pubmed	Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification.	SUPT20HL1 SUPT20HL2	9.27e-05	8	64	2	21802298
Pubmed	Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors.	RYR1 RYR3	9.27e-05	8	64	2	21441923
Pubmed	ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.	RYR1 RYR3	9.27e-05	8	64	2	30563862
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	RYR1 RYR3	9.27e-05	8	64	2	11784029
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR1 RYR3	9.27e-05	8	64	2	19033399
Pubmed	Phospho-tyrosine dependent protein-protein interaction network.	KMT2B NGEF CBL GAREM1 ZNF71 CAPN10	1.09e-04	410	64	6	25814554
Pubmed	Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy.	RYR1 RYR3	1.19e-04	9	64	2	21858002
Pubmed	Analysis of a new allele of limb deformity (ld) reveals tissue- and age-specific transcriptional effects of the Ld Global Control Region.	FMN1 RYR3	1.19e-04	9	64	2	17554679
Pubmed	ADAMTS: a novel family of extracellular matrix proteases.	ADAMTS10 ADAMTS6	1.49e-04	10	64	2	11167130
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	VTN ADAMTS6 REV3L CBL SMCR8 RYR1 AHNAK2	1.70e-04	638	64	7	31182584
Pubmed	The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.	CBL GAB1	1.81e-04	11	64	2	11894096
Pubmed	Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.	SUPT20HL1 SUPT20HL2	1.81e-04	11	64	2	24051374
Pubmed	Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients.	FMN1 RYR3	1.81e-04	11	64	2	19096130
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	STARD9 SPEG ZNF398 CRAMP1	1.86e-04	153	64	4	10718198
Pubmed	Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.	SUPT20HL1 MRPS15 SUPT20HL2 PKN2 CRAMP1 PRDM2	1.96e-04	457	64	6	32968282
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	RYR1 RYR3	2.17e-04	12	64	2	19095005
Pubmed	MED12 regulates a transcriptional network of calcium-handling genes in the heart.	TNNT1 RYR1	2.99e-04	14	64	2	28724790
Pubmed	Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains.	KMT2B FMN1	2.99e-04	14	64	2	8605874
Pubmed	PDZ-Containing Proteins Targeted by the ACE2 Receptor.	MAST1 SHROOM2	3.45e-04	15	64	2	34835087
Pubmed	A primary expression map of the chromosome 15q15 region containing the recessive form of limb-girdle muscular dystrophy (LGMD2A) gene.	FMN1 STARD9	3.93e-04	16	64	2	7633422
Pubmed	Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.	ADAMTS10 ADAMTS6	5.00e-04	18	64	2	35503090
Pubmed	Genomic analysis of mouse retinal development.	CLIP3 VTN KMT2B ZFP41 CARF MAST1 SAMD7 UBN2	5.03e-04	1006	64	8	15226823
Pubmed	Cripto is required for mesoderm and endoderm cell allocation during mouse gastrulation.	SUPT20HL1 SUPT20HL2	6.84e-04	21	64	2	23747598
Pubmed	Supt20 is required for development of the axial skeleton.	SUPT20HL1 SUPT20HL2	6.84e-04	21	64	2	27894818
Pubmed	p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.	SUPT20HL1 SUPT20HL2	7.52e-04	22	64	2	16751104
Pubmed	FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.	NGEF RYR1	7.52e-04	22	64	2	26494785
Pubmed	Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.	CBL GAB1 GAREM1	9.22e-04	103	64	3	21706016
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	ZNF469 ATG2A TSC22D2 GAB1 GAREM1	1.18e-03	430	64	5	35044719
Pubmed	The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.	SUPT20HL1 SUPT20HL2	1.22e-03	28	64	2	19114550
Pubmed	Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.	CBL GAB1	1.40e-03	30	64	2	12522270
Pubmed	A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.	SUPT20HL1 SUPT20HL2	1.40e-03	30	64	2	18206972
Pubmed	Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.	VTN C7	1.60e-03	32	64	2	18842294
Pubmed	Characterization of long cDNA clones from human adult spleen.	ZFP41 FGD3	1.70e-03	33	64	2	11214971
Pubmed	Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.	SUPT20HL1 SUPT20HL2	1.70e-03	33	64	2	11564863
Pubmed	Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor.	CBL GAB1	1.70e-03	33	64	2	18271526
Pubmed	Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.	MAST1 SHROOM2	1.80e-03	34	64	2	30726710
Cytoband	19q13.4	BRSK1 TNNT1 ZNF71	1.89e-04	79	64	3	19q13.4
Cytoband	Xp22.11	SUPT20HL1 SUPT20HL2	3.95e-04	21	64	2	Xp22.11
Cytoband	Ensembl 112 genes in cytogenetic band chr7q36	KRBA1 ZNF862 ZNF398	1.45e-03	159	64	3	chr7q36
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR3	1.81e-05	3	45	2	287
GeneFamily	C2 domain containing protein kinases	PKN2 PRKCQ	2.69e-04	10	45	2	835
GeneFamily	PDZ domain containing	MAST1 SHROOM2 RGS3 AHNAK2	5.47e-04	152	45	4	1220
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS10 ADAMTS6	1.01e-03	19	45	2	50
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2B PRDM2	3.23e-03	34	45	2	487
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	SNAPC4 CRAMP1	7.70e-03	53	45	2	532
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	NGEF FGD3	1.17e-02	66	45	2	722
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS10 RRAS2 STARD9 RECQL5 KIAA1614 RYR3	1.61e-07	169	64	6	16c52a0f6d96ecc1832922fce9b39691849f0d73
ToppCell	Tracheal-10x5prime-Stromal-Fibroblastic-Fibro_immune_recruiting\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS10 DNAAF11 C7 TSC22D2 BRSK1 CRAMP1	4.33e-07	200	64	6	f692b602bc989d35c9162e73dda813dbef8d5267
Drug	strontium	PKN2 PRKCQ TNNT1 RYR1 RYR3	1.07e-06	68	61	5	CID000104798
Drug	5'-adenylyl (beta,gamma-methylene)diphosphonate	RYR1 RYR3	7.06e-06	2	61	2	ctd:C005147
Drug	loperamide	HTR3A PKN2 PRKCQ RYR1 RYR3	9.18e-06	105	61	5	CID000003954
Drug	sevoflurane	HTR3A PKN2 PRKCQ RYR1 RYR3	9.18e-06	105	61	5	CID000005206
Drug	Suprofen [40828-46-4]; Down 200; 15.4uM; HL60; HT_HG-U133A	ZNF862 RECQL5 TSC22D2 RGS3 GAB1 GAREM1	1.45e-05	197	61	6	3005_DN
Drug	2-hydroxycarbazole	RYR1 RYR3	2.11e-05	3	61	2	CID000093551
Drug	1,1'-diheptyl-4,4'-bipyridinium	RYR1 RYR3	2.11e-05	3	61	2	CID000080262
Drug	cis-diammineplatinum(II	RYR1 RYR3	2.11e-05	3	61	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR1 RYR3	2.11e-05	3	61	2	CID002750949
Drug	flubendiamide	RYR1 RYR3	2.11e-05	3	61	2	CID011193251
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR3	2.11e-05	3	61	2	CID005748312
Drug	8N3-cADPR	RYR1 RYR3	2.11e-05	3	61	2	CID000127713
Drug	aminodantrolene	RYR1 RYR3	2.11e-05	3	61	2	CID009570289
Drug	NSC613009	VTN MYRIP GAB1 RYR1 RYR3	2.59e-05	130	61	5	CID000003800
Drug	A-30	RYR1 RYR3	4.22e-05	4	61	2	CID003028528
Drug	PCB74	RYR1 RYR3	4.22e-05	4	61	2	CID000036218
Drug	148504-47-6	RYR1 RYR3	4.22e-05	4	61	2	CID006444275
Drug	Bastadin 10	RYR1 RYR3	4.22e-05	4	61	2	CID009589366
Drug	SC 38249	RYR1 RYR3	4.22e-05	4	61	2	CID000134834
Drug	AC1L1U7A	RYR1 RYR3	4.22e-05	4	61	2	CID000035682
Drug	procaine	HTR3A PKN2 PRKCQ RYR1 RYR3	5.64e-05	153	61	5	CID000004914
Drug	M3/M4	HTR3A RYR1 RYR3	8.59e-05	32	61	3	CID000486507
Drug	tetracaine	PKN2 PRKCQ RYR1 RYR3	9.19e-05	88	61	4	CID000005411
Drug	MBED	RYR1 RYR3	1.05e-04	6	61	2	CID000129958
Drug	chloro-m-cresol	RYR1 RYR3	1.05e-04	6	61	2	CID000012008
Drug	AC1O528X	RYR1 RYR3	1.05e-04	6	61	2	CID006475857
Drug	NSC114784	RYR1 RYR3	1.05e-04	6	61	2	CID000419425
Drug	NSC692750	RYR1 RYR3	1.05e-04	6	61	2	CID000078910
Drug	LY 294002; Up 200; 10uM; PC3; HT_HG-U133A	CARF PKN2 RGS3 GAB1 GAREM1	1.42e-04	186	61	5	4460_UP
Drug	AC1L98DX	CRAMP1 RYR1 RYR3	1.44e-04	38	61	3	CID000439957
Drug	Azumoleno	RYR1 RYR3	1.47e-04	7	61	2	CID000056259
Drug	mag-indo-1	RYR1 RYR3	1.47e-04	7	61	2	CID000131881
Drug	Br2BAPTA	RYR1 RYR3	1.47e-04	7	61	2	CID003081001
Drug	[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate	RYR1 RYR3	1.47e-04	7	61	2	CID009547999
Drug	CHEBI:564108	RYR1 RYR3	1.47e-04	7	61	2	CID006400637
Drug	NAADP	TRPM2 RYR1 RYR3	1.56e-04	39	61	3	CID000123952
Drug	CID9959010	TRPM2 RYR1 RYR3	1.56e-04	39	61	3	CID009959010
Drug	allodeoxycholic acid	PKN2 PRKCQ DNAAF11 TNNT1 RYR1	1.56e-04	190	61	5	CID000002987
Drug	Tiabendazole [148-79-8]; Up 200; 19.8uM; MCF7; HT_HG-U133A	ZNF862 CIZ1 GAB1 PRDM2 AHNAK2	1.60e-04	191	61	5	2840_UP
Drug	Corticosterone [50-22-6]; Down 200; 11.6uM; HL60; HT_HG-U133A	ZNF862 RECQL5 CIZ1 ATG2A TSC22D2	1.72e-04	194	61	5	1307_DN
Drug	Famprofazone [22881-35-2]; Down 200; 10.6uM; MCF7; HT_HG-U133A	KMT2B ZNF862 CIZ1 GAB1 CAPN10	1.77e-04	195	61	5	3834_DN
Drug	Harpagoside [19210-12-9]; Down 200; 8uM; HL60; HT_HG-U133A	SNAPC4 TNNT1 RGS3 PRDM2 CAPN10	1.81e-04	196	61	5	2935_DN
Drug	Lomefloxacin hydrochloride [98079-52-8]; Up 200; 10.4uM; MCF7; HT_HG-U133A	HTR3A SPEG PRKCQ CBL AHNAK2	1.81e-04	196	61	5	2310_UP
Drug	Lithocholic acid [434-13-9]; Down 200; 10.6uM; PC3; HT_HG-U133A	ZNF862 SPEG RECQL5 CIZ1 PRDM2	1.81e-04	196	61	5	3816_DN
Drug	Sulpiride [15676-16-1]; Up 200; 11.8uM; PC3; HG-U133A	HIRIP3 RECQL5 TSC22D2 SNAPC4 CAPN10	1.85e-04	197	61	5	1887_UP
Drug	Guanethidine sulfate [60-02-6]; Down 200; 13.4uM; PC3; HT_HG-U133A	ZNF862 SPEG TSC22D2 RGS3 CAPN10	1.90e-04	198	61	5	5731_DN
Drug	3-Acetylcoumarin [3949-36-8]; Down 200; 21.2uM; MCF7; HT_HG-U133A	KMT2B CIZ1 RGS3 GAB1 PRDM2	1.90e-04	198	61	5	5259_DN
Drug	Tracazolate hydrochloride [41094-88-6]; Up 200; 11.8uM; MCF7; HT_HG-U133A	CARF DNAAF11 RYR1 AHNAK2 CAPN10	1.90e-04	198	61	5	4964_UP
Drug	Dizocilpine maleate [77086-22-7]; Down 200; 11.8uM; PC3; HT_HG-U133A	KMT2B ZNF862 TSC22D2 SNAPC4 PRDM2	1.90e-04	198	61	5	2069_DN
Drug	Diprophylline [479-18-5]; Up 200; 15.8uM; MCF7; HT_HG-U133A	ZNF862 CNGB3 GAB1 RYR1 PRDM2	1.90e-04	198	61	5	1689_UP
Drug	Austricine [10180-88-8]; Up 200; 14.2uM; PC3; HT_HG-U133A	SPEG CARF CNGB3 CBL GAB1	1.94e-04	199	61	5	4213_UP
Drug	alpha-phellandrene	VTN SPEG	1.96e-04	8	61	2	CID000007460
Drug	phosphine oxide	PKN2 PRKCQ RYR1 RYR3	1.96e-04	107	61	4	CID000166931
Drug	valdecoxib; Up 200; 10uM; MCF7; HT_HG-U133A	HTR3A SPEG CNGB3 TRPM2 TSC22D2	1.99e-04	200	61	5	6403_UP
Drug	Khellin [82-02-0]; Up 200; 15.4uM; PC3; HG-U133A	HIRIP3 RECQL5 CIZ1 SNAPC4 PRDM2	1.99e-04	200	61	5	1922_UP
Drug	thiopental	PKN2 PRKCQ RYR1 RYR3	2.33e-04	112	61	4	CID003000715
Drug	lactosyl lysosphingolipid	RYR1 RYR3	2.51e-04	9	61	2	CID006439268
Drug	Ro 16-6491	HTR3A PRDM2	2.51e-04	9	61	2	CID000004289
Drug	FLA 365	RYR1 RYR3	2.51e-04	9	61	2	CID000072776
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR3	1.18e-05	3	59	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR3	1.18e-05	3	59	2	DOID:8545 (implicated_via_orthology)
Disease	Myopathy, Centronuclear, Autosomal Recessive	SPEG RYR1	2.35e-05	4	59	2	C0410204
Disease	ERO1-like protein alpha measurement	VTN C7	5.87e-05	6	59	2	EFO_0801582
Disease	protocadherin beta-4 measurement	VTN C7	5.87e-05	6	59	2	EFO_0801976
Disease	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 measurement	VTN C7	5.87e-05	6	59	2	EFO_0801372
Disease	apolipoprotein D measurement	VTN C7	1.40e-04	9	59	2	EFO_0020156
Disease	complement C1q and tumor necrosis factor-related protein 9A measurement	VTN C7	1.40e-04	9	59	2	EFO_0803293
Disease	interleukin-34 measurement	VTN C7	1.40e-04	9	59	2	EFO_0020505
Disease	dickkopf-like protein 1 measurement	VTN C7	1.40e-04	9	59	2	EFO_0020324
Disease	leucine-rich repeat serine/threonine-protein kinase 2 measurement	VTN C7	1.40e-04	9	59	2	EFO_0021876
Disease	cyclin-dependent kinase 5:cyclin-dependent kinase 5 activator 1 complex measurement	VTN C7	1.40e-04	9	59	2	EFO_0020296
Disease	oxysterols receptor LXR-beta measurement	VTN C7	1.40e-04	9	59	2	EFO_0801865
Disease	serine/threonine-protein kinase 16 measurement	VTN C7	1.75e-04	10	59	2	EFO_0020724
Disease	interleukin-37 measurement	VTN C7	1.75e-04	10	59	2	EFO_0020506
Disease	insulin growth factor-like family member 3 measurement	VTN C7	1.75e-04	10	59	2	EFO_0801700
Disease	tumor necrosis factor receptor superfamily member 11B measurement	VTN C7	2.14e-04	11	59	2	EFO_0020801
Disease	interleukin-10 receptor subunit alpha measurement	VTN C7	2.14e-04	11	59	2	EFO_0021890
Disease	guanylate-binding protein 6 measurement	VTN C7	2.14e-04	11	59	2	EFO_0801662
Disease	glycerol-3-phosphate dehydrogenase 1-like protein measurement	VTN C7	2.14e-04	11	59	2	EFO_0801640
Disease	complement component C7 measurement	VTN C7	2.56e-04	12	59	2	EFO_0008093
Disease	non-lobar intracerebral hemorrhage	CARF DNAH14 ZNF71	2.77e-04	63	59	3	EFO_0010178
Disease	kallikrein-12 measurement	VTN C7	3.02e-04	13	59	2	EFO_0008194
Disease	Autosomal Recessive Centronuclear Myopathy	SPEG RYR1	4.06e-04	15	59	2	C3645536
Disease	SLAM family member 7 measurement	VTN C7	5.24e-04	17	59	2	EFO_0008287
Disease	Dystonia, Limb	KMT2B CIZ1	5.24e-04	17	59	2	C0751093
Disease	Dystonia, Diurnal	KMT2B CIZ1	5.24e-04	17	59	2	C0393610
Disease	Dystonia, Paroxysmal	KMT2B CIZ1	5.89e-04	18	59	2	C0393588
Disease	Juvenile Myelomonocytic Leukemia	RRAS2 CBL	6.58e-04	19	59	2	C0349639
Disease	Noonan Syndrome	RRAS2 CBL	1.05e-03	24	59	2	C0028326
Disease	congestive heart failure (is_implicated_in)	CBL RYR1	1.34e-03	27	59	2	DOID:6000 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PESPRCQPKPSEEAP	CCDC86	111	Q9H6F5
PQDFEKSPRDRCSPP	HTR3A	391	P46098
PQEICATPRLFPDDP	CAPN10	46	Q9HC96
PCELREPEPSPFSSK	ATG2A	766	Q2TAZ0
KALDDSACPQPRPPV	ADAMTS10	921	Q9H324
PAAQCPEESKPPVRI	ADAMTS6	996	Q9UKP5
PAIQESPTRDLPPCQ	RGS3	801	P49796
QRRESCPPDIPKTPD	FMN1	231	Q68DA7
LPQERDRLPSCKPPV	KRBA1	666	A5PL33
NEARPPCLPTPGKRE	PRKCQ	326	Q04759
RPPTPCSDPERKRFR	HIRIP3	81	Q9BW71
VADCEPPPVDRNLKP	GAB1	511	Q13480
PCSREPEPPLENSRD	KIAA1614	906	Q5VZ46
AQKTPPADPACPERE	LBHD1	261	Q9BQE6
PRDVPEEKPSNRNLP	CARF	141	Q8N187
SCPALPPRAPKLVEE	GAREM1	721	Q9H706
PEPEEQSRPRKPTLQ	KMT2B	1116	Q9UMN6
PLPSCKLSVPDPEER	FGD3	651	Q5JSP0
DTDTFCPPRPKPVAR	MIEF1	106	Q9NQG6
TDRPRPGDLCPPSKD	MAST1	856	Q9Y2H9
SPEENLRKRPAEPSP	FER1L6-AS2	61	Q96M78
DSERRPSCDIDKPPP	C7	121	P10643
PSCDIDKPPPNIELT	C7	126	P10643
RPPPRHQDTGPCLEK	CRAMP1	511	Q96RY5
PRNDVDPPRKRVDSP	BRSK1	371	Q8TDC3
RRPEPKIIPSEEDPT	DNAAF11	441	Q86X45
REASLPKCPPEDVPL	DNAH14	1351	Q0VDD8
DCPSRDKLPPVPSSR	CBL	571	P22681
RRCADDQPPSILDPP	MST1	446	P26927
PVPEAPSPTQERRQK	CLIP3	26	Q96DZ5
SERKNPAPQCPPRLE	RYR1	1581	P21817
DNVPICPPRDPTVSI	CDH16	331	O75309
RSPSPCKSLEAQPDP	PRDM2	911	Q13029
RKPAQSRLDDDPPPS	MRPS15	56	P82914
PTKPPETEAQRGPCL	RPUSD1	286	Q9UJJ7
PPSQPSCPAREKAQE	TNNT1	211	P13805
QEQSDCPPPPELRVS	SUPT20HL1	251	Q3ZLR7
VDDTRRKSEPLPQPP	TSC22D2	591	O75157
DEKNGVCPPVPRPSL	SAMD7	291	Q7Z3H4
EPASPPERKTLPQIC	NGEF	226	Q8N5V2
RKFQEQECPPSPEPT	RRAS2	176	P62070
QECPPSPEPTRKEKD	RRAS2	181	P62070
TQVPPEKDRCTSPPG	SHROOM2	1286	Q13796
SPDATVPRPPCRSKL	STARD9	811	Q9P2P6
TDCPRTPDTPNNDPR	PKN2	116	Q16513
DRPPSSSLEECPIPK	SMCR8	396	Q8TEV9
QEQSDCPPPPELRVS	SUPT20HL2	251	P0C7V6
IAPTPEDPLQPSCRK	AHNAK2	5151	Q8IVF2
PEEKPLDRPECTASP	CNGB3	746	Q9NQW8
EKRTPAPEPEPCEAS	CIZ1	241	Q9ULV3
PAPPQTEECLRERPS	RECQL5	816	O94762
SCKPEEGPERPQDTP	TEX13D	556	A0A0J9YY54
TVPRKPRTEPCLSPE	ZFP41	41	Q8N8Y5
EPAPRSDAQPPSREK	UBN2	56	Q6ZU65
EPFCSNPSDVPEKPR	REV3L	1906	O60673
AQDKAPEPRPEPVRA	SPEG	2211	Q15772
RSEEKNPVPQCPPRL	RYR3	1476	Q15413
VEDPERPACAPAAPR	TRPM2	541	O94759
NSTERPFPCPDCPKR	ZNF398	421	Q8TD17
EEPRTQKPPILPSRE	ZNF862	1126	O60290
SRPPQDVCLPEPSKQ	ZNF469	1686	Q96JG9
NREPEPSCRTDTPAP	SNAPC4	1141	Q5SXM2
RPQPPAEEELCSGKP	VTN	146	P04004
PRLDDPTEKGACPPV	ZNF71	91	Q9NQZ8
PSPAEQPTCKEIPDL	UBXN8	166	O00124
KTPPVEAPSRQPRDQ	MYRIP	306	Q8NFW9