Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	MC4R MC5R OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 GRM4 LGR5 OR51Q1 GPR158 OR5B2 BDKRB2 OR10J3 OR8K5	2.76e-12	884	39	16	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	MC4R MC5R OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 GRM4 LGR5 OR51Q1 GPR158 OR5B2 BDKRB2 OR10J3 OR8K5	1.54e-09	1353	39	16	GO:0004888
GeneOntologyMolecularFunction	olfactory receptor activity	OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 OR51Q1 OR5B2 OR10J3 OR8K5	7.19e-09	431	39	10	GO:0004984
GeneOntologyMolecularFunction	melanocortin receptor activity	MC4R MC5R	5.55e-05	6	39	2	GO:0004977
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	MC4R MC5R LGR5 BDKRB2	1.29e-04	133	39	4	GO:0008528
GeneOntologyMolecularFunction	peptide receptor activity	MC4R MC5R LGR5 BDKRB2	1.57e-04	140	39	4	GO:0001653
GeneOntologyMolecularFunction	adenylate cyclase activity	ADCY8 ADCY9	5.58e-04	18	39	2	GO:0004016
GeneOntologyMolecularFunction	cyclase activity	ADCY8 ADCY9	9.98e-04	24	39	2	GO:0009975
GeneOntologyMolecularFunction	phosphorus-oxygen lyase activity	ADCY8 ADCY9	1.08e-03	25	39	2	GO:0016849
GeneOntologyMolecularFunction	odorant binding	OR5B2 OR10J3 OR8K5	1.94e-03	127	39	3	GO:0005549
GeneOntologyMolecularFunction	protein serine/threonine/tyrosine kinase activity	MAPK10 DYRK2	3.80e-03	47	39	2	GO:0004712
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	MC4R MC5R OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 GRM4 LGR5 IL2 OR51Q1 GPR158 OR5B2 BDKRB2 OR10J3 ADCY8 ADCY9 OR8K5	5.39e-13	1395	38	19	GO:0007186
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 OR51Q1 OR5B2 OR10J3 OR8K5	4.10e-09	432	38	10	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 OR51Q1 OR5B2 OR10J3 OR8K5	8.27e-09	465	38	10	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 OR51Q1 OR5B2 OR10J3 OR8K5	1.23e-08	485	38	10	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 OR51Q1 OR5B2 OR10J3 OR8K5	2.56e-08	524	38	10	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 OR51Q1 OR5B2 OR10J3 OR8K5	3.84e-08	547	38	10	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 OR51Q1 OR5B2 OR10J3 OR8K5	6.87e-08	582	38	10	GO:0050906
GeneOntologyBiologicalProcess	sensory perception	OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 POMK OR51Q1 OR5B2 OR10J3 MIP OR8K5	2.81e-07	1072	38	12	GO:0007600
GeneOntologyBiologicalProcess	detection of stimulus	OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 OR51Q1 OR5B2 OR10J3 OR8K5	5.05e-07	722	38	10	GO:0051606
GeneOntologyBiologicalProcess	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	MC4R MC5R OR51E2 GRM4 LGR5 ADCY8 ADCY9	8.00e-07	286	38	7	GO:0007188
GeneOntologyBiologicalProcess	adenylate cyclase-activating G protein-coupled receptor signaling pathway	MC4R MC5R OR51E2 LGR5 ADCY8 ADCY9	1.26e-06	191	38	6	GO:0007189
GeneOntologyBiologicalProcess	cAMP biosynthetic process	ADCY8 ADCY9	1.80e-04	11	38	2	GO:0006171
GeneOntologyBiologicalProcess	secretion	MC4R OR51E2 TPCN2 GRM4 GPR158 BDKRB2 ADCY8 MADD MIP	2.96e-04	1221	38	9	GO:0046903
Domain	GPCR_Rhodpsn_7TM	MC4R MC5R OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 LGR5 OR51Q1 OR5B2 BDKRB2 OR10J3 OR8K5	3.36e-11	670	39	14	IPR017452
Domain	7tm_1	MC4R MC5R OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 LGR5 OR51Q1 OR5B2 BDKRB2 OR10J3 OR8K5	3.86e-11	677	39	14	PF00001
Domain	G_PROTEIN_RECEP_F1_1	MC4R MC5R OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 LGR5 OR51Q1 OR5B2 BDKRB2 OR10J3 OR8K5	4.51e-11	685	39	14	PS00237
Domain	G_PROTEIN_RECEP_F1_2	MC4R MC5R OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 LGR5 OR51Q1 OR5B2 BDKRB2 OR10J3 OR8K5	5.06e-11	691	39	14	PS50262
Domain	GPCR_Rhodpsn	MC4R MC5R OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 LGR5 OR51Q1 OR5B2 BDKRB2 OR10J3 OR8K5	5.16e-11	692	39	14	IPR000276
Domain	Olfact_rcpt	OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 OR51Q1 OR5B2 OR10J3 OR8K5	5.60e-09	393	39	10	IPR000725
Domain	Melancort_rcpt	MC4R MC5R	1.27e-05	3	39	2	IPR001908
Domain	Melcrt_ACTH_rcpt	MC4R MC5R	6.34e-05	6	39	2	IPR001671
Domain	A/G_cyclase_CS	ADCY8 ADCY9	5.66e-04	17	39	2	IPR018297
Domain	Nucleotide_cyclase	ADCY8 ADCY9	6.36e-04	18	39	2	IPR029787
Domain	-	ADCY8 ADCY9	6.36e-04	18	39	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_2	ADCY8 ADCY9	7.10e-04	19	39	2	PS50125
Domain	GUANYLATE_CYCLASE_1	ADCY8 ADCY9	7.10e-04	19	39	2	PS00452
Domain	A/G_cyclase	ADCY8 ADCY9	7.10e-04	19	39	2	IPR001054
Domain	CYCc	ADCY8 ADCY9	7.10e-04	19	39	2	SM00044
Domain	Guanylate_cyc	ADCY8 ADCY9	7.10e-04	19	39	2	PF00211
Domain	GPCR_3	GRM4 GPR158	8.70e-04	21	39	2	IPR000337
Domain	G_PROTEIN_RECEP_F3_4	GRM4 GPR158	9.56e-04	22	39	2	PS50259
Domain	7tm_3	GRM4 GPR158	9.56e-04	22	39	2	PF00003
Domain	GPCR_3_C	GRM4 GPR158	9.56e-04	22	39	2	IPR017978
Domain	G_PROTEIN_RECEP_F3_2	GRM4 GPR158	9.56e-04	22	39	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GRM4 GPR158	9.56e-04	22	39	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GRM4 GPR158	9.56e-04	22	39	2	PS00979
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 OR51Q1 OR5B2 OR10J3 OR8K5	7.85e-08	417	37	10	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR1E2 OR51E2 OR2T1 OR10H5 OR4F21 OR7C2 GRM4 OR51Q1 OR5B2 OR10J3 OR8K5	4.23e-07	636	37	11	M41834
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR1E2 OR51E2 OR2T1 OR10H5 OR7C2 OR51Q1 OR10J3 OR8K5	5.99e-06	389	37	8	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR1E2 OR51E2 OR2T1 OR10H5	3.25e-05	70	37	4	MM14984
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	MC4R MC5R OR1E2 OR2T1 OR7C2 BDKRB2	5.34e-05	260	37	6	M39397
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY8 ADCY9	2.98e-04	10	37	2	M19522
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY8 ADCY9	2.98e-04	10	37	2	MM14668
Pathway	REACTOME_AQUAPORIN_MEDIATED_TRANSPORT	ADCY8 ADCY9 MIP	3.37e-04	52	37	3	M920
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY8 ADCY9	5.98e-04	14	37	2	MM14669
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY8 ADCY9	5.98e-04	14	37	2	M750
Pathway	KEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY	ADCY8 ADCY9	6.89e-04	15	37	2	M47794
Pathway	PID_LPA4_PATHWAY	ADCY8 ADCY9	6.89e-04	15	37	2	M56
Pathway	KEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY	ADCY8 ADCY9	6.89e-04	15	37	2	M47504
Pathway	REACTOME_G_ALPHA_S_SIGNALLING_EVENTS	MC4R MC5R ADCY8 ADCY9	7.35e-04	157	37	4	M4904
Pathway	WP_MAJOR_RECEPTORS_TARGETED_BY_EPINEPHRINE_AND_NOREPINEPHRINE	ADCY8 ADCY9	7.86e-04	16	37	2	M39849
Pathway	KEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY	ADCY8 ADCY9	7.86e-04	16	37	2	M47645
Pathway	KEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY	ADCY8 ADCY9	7.86e-04	16	37	2	M47650
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY8 ADCY9	7.86e-04	16	37	2	MM14492
Pathway	WP_GPCRS_PEPTIDE	MC4R MC5R BDKRB2	8.07e-04	70	37	3	MM15959
Pathway	REACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING	ADCY8 ADCY9	8.89e-04	17	37	2	M26995
Pathway	KEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY	ADCY8 ADCY9	8.89e-04	17	37	2	M47544
Pathway	WP_PEPTIDE_GPCRS	MC4R MC5R BDKRB2	9.87e-04	75	37	3	M39696
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY8 ADCY9	1.24e-03	20	37	2	M759
Pathway	KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION	MAPK10 ADCY8 ADCY9	1.42e-03	85	37	3	M3578
Pathway	REACTOME_SENSORY_PERCEPTION	OR1E2 OR51E2 OR2T1 OR10H5	1.49e-03	190	37	4	MM15687
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY8 ADCY9	1.78e-03	24	37	2	M47520
Pathway	WP_GPCRS_OTHER	MC4R OR1E2 OR2T1	2.01e-03	96	37	3	MM15939
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAI_AC_PKA_SIGNALING_PATHWAY	ADCY8 ADCY9	2.09e-03	26	37	2	M47553
Pathway	REACTOME_CA_DEPENDENT_EVENTS	ADCY8 ADCY9	2.09e-03	26	37	2	MM14495
Pathway	KEGG_MEDICUS_REFERENCE_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY8 ADCY9	2.26e-03	27	37	2	M47518
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_RASD1_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY8 ADCY9	2.26e-03	27	37	2	M47519
Pathway	KEGG_GNRH_SIGNALING_PATHWAY	MAPK10 ADCY8 ADCY9	2.32e-03	101	37	3	M1979
Pathway	WP_T_CELL_RECEPTOR_AND_COSTIMULATORY_SIGNALING	IL2 DYRK2	2.43e-03	28	37	2	M39632
Pathway	KEGG_MEDICUS_REFERENCE_GHRHR_PKA_GH_SIGNALING_PATHWAY	ADCY8 ADCY9	2.43e-03	28	37	2	M47647
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_ACTH_CORTISOL_SIGNALING_PATHWAY	ADCY8 ADCY9	2.60e-03	29	37	2	M47515
Pathway	KEGG_MEDICUS_REFERENCE_TSH_TG_SIGNALING_PATHWAY	ADCY8 ADCY9	2.60e-03	29	37	2	M47627
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	TPCN2 SLC34A1 ADCY8 ADCY9 SLCO1A2 MIP SLC35A1	2.68e-03	736	37	7	M27287
Pathway	KEGG_MEDICUS_VARIANT_CYP11B1_CYP11B2_FUSION_TO_ACTH_CORTISOL_SIGNALING_PATHWAY	ADCY8 ADCY9	2.97e-03	31	37	2	M47507
Pathway	KEGG_MEDICUS_REFERENCE_ACTH_CORTISOL_SIGNALING_PATHWAY	ADCY8 ADCY9	3.16e-03	32	37	2	M47506
Pathway	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	ADCY8 ADCY9	3.36e-03	33	37	2	MM15058
Pathway	REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION	ADCY8 ADCY9	3.36e-03	33	37	2	M11575
Pathway	KEGG_MEDICUS_REFERENCE_ADRB3_UCP1_SIGNALING_PATHWAY	ADCY8 ADCY9	3.78e-03	35	37	2	M47969
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR1E2 OR51E2 OR2T1 OR4F21 OR7C2 OR51Q1 OR5B2 OR10J3 OR8K5	1.20e-10	340	39	9	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR1E2 OR51E2 OR2T1 OR4F21 OR7C2 OR51Q1 OR5B2 OR10J3 OR8K5	1.20e-10	340	39	9	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR1E2 OR51E2 OR2T1 OR4F21 OR7C2 OR51Q1 OR5B2 OR10J3 OR8K5	1.30e-10	343	39	9	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR1E2 OR51E2 OR2T1 OR4F21 OR7C2 OR51Q1 OR5B2 OR10J3 OR8K5	1.40e-10	346	39	9	14611657
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR1E2 OR4F21 OR7C2 OR10J3 OR8K5	2.07e-08	74	39	5	15081110
Pubmed	The human olfactory receptor gene family.	OR1E2 OR51E2 OR2T1 OR10H5 OR7C2 OR5B2 OR10J3 OR8K5	1.31e-07	541	39	8	14983052
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR1E2 OR2T1 OR10H5 OR7C2 OR5B2 OR10J3	1.60e-07	219	39	6	12213199
Pubmed	Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.	MC4R MC5R	3.67e-06	3	39	2	17482720
Pubmed	Distribution of olfactory receptor genes in the human genome.	OR1E2 OR2T1 OR7C2	4.19e-06	28	39	3	9500546
Pubmed	Ascorbic acid is a regulator of the intracellular cAMP concentration: old molecule, new functions?	ADCY8 ADCY9	7.34e-06	4	39	2	18835269
Pubmed	Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes.	MC4R MC5R	7.34e-06	4	39	2	15470082
Pubmed	Adrenocorticotropic hormone directly stimulates testosterone production by the fetal and neonatal mouse testis.	MC4R MC5R	1.22e-05	5	39	2	12865302
Pubmed	Molecular cloning, expression, and characterization of a fifth melanocortin receptor.	MC4R MC5R	1.22e-05	5	39	2	8185570
Pubmed	gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes.	MAPK10 IL2	1.22e-05	5	39	2	9045910
Pubmed	Biphasic effect of melanocortin agonists on metabolic rate and body temperature.	MC4R MC5R	1.83e-05	6	39	2	24981835
Pubmed	Melanocortin receptor binding determinants in the agouti protein.	MC4R MC5R	1.83e-05	6	39	2	9454589
Pubmed	Further evidence for the role of ENPP1 in obesity: association with morbid obesity in Finns.	MC4R MC5R	1.83e-05	6	39	2	18551113
Pubmed	The structure and evolution of the melanocortin and MCH receptors in fish and mammals.	MC4R MC5R	2.56e-05	7	39	2	12620396
Pubmed	MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family.	MC4R MC5R	2.56e-05	7	39	2	19329486
Pubmed	Effects of recombinant agouti-signaling protein on melanocortin action.	MC4R MC5R	2.56e-05	7	39	2	9058374
Pubmed	Agouti/melanocortin interactions with leptin pathways in obesity.	MC4R MC5R	3.42e-05	8	39	2	9763877
Pubmed	Role of the calcium modulated cyclases in the development of the retinal projections.	ADCY8 ADCY9	4.39e-05	9	39	2	17229090
Pubmed	Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.	ADCY8 ADCY9	4.39e-05	9	39	2	9417641
Pubmed	Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.	ADCY8 ADCY9	4.39e-05	9	39	2	12503609
Pubmed	Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.	IL2 SLCO1A2	5.48e-05	10	39	2	21685912
Pubmed	Purification and characterization of a soluble form of mammalian adenylyl cyclase.	ADCY8 ADCY9	5.48e-05	10	39	2	8663304
Pubmed	Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.	ADCY8 ADCY9	5.48e-05	10	39	2	11884542
Pubmed	Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.	ADCY8 ADCY9	5.48e-05	10	39	2	16615126
Pubmed	Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.	ADCY8 ADCY9	6.70e-05	11	39	2	10089566
Pubmed	gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.	ADCY8 ADCY9	6.70e-05	11	39	2	10808179
Pubmed	Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.	ADCY8 ADCY9	6.70e-05	11	39	2	11299302
Pubmed	HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.	ADCY8 ADCY9	8.03e-05	12	39	2	10807185
Pubmed	Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.	MC4R LGR5 MADD	8.32e-05	75	39	3	20571754
Pubmed	Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.	ADCY8 ADCY9	1.11e-04	14	39	2	14993377
Pubmed	cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.	ADCY8 ADCY9	1.27e-04	15	39	2	2165385
Pubmed	Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.	ADCY8 ADCY9	1.46e-04	16	39	2	17567809
Pubmed	Expression patterns of the aquaporin gene family during renal development: influence of genetic variability.	SLC34A1 MIP	2.07e-04	19	39	2	19367412
Pubmed	Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes.	MC4R LGR5	2.79e-04	22	39	2	19794065
Pubmed	The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates.	OR1E2 OR7C2	3.05e-04	23	39	2	10706615
Pubmed	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	GRM4 ADCY8 ADCY9	3.18e-04	118	39	3	19156168
Pubmed	Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.	OR1E2 OR2T1	3.33e-04	24	39	2	9119360
Pubmed	Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.	OR51Q1 OR8K5	4.23e-04	27	39	2	32061665
Pubmed	Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.	MC4R ADCY9	4.55e-04	28	39	2	24861553
Pubmed	Glucagon and regulation of glucose metabolism.	ADCY8 ADCY9	5.58e-04	31	39	2	12626323
Pubmed	Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.	IL2 COL21A1	5.95e-04	32	39	2	23817571
Pubmed	A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network.	TRMT11 STAG1	9.30e-04	40	39	2	20308539
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	MC4R SERINC3 TPCN2 BDKRB2 SLC35A1	1.04e-03	697	39	5	28298427
GeneFamily	Melanocortin receptors	MC4R MC5R	3.42e-05	5	34	2	236
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY8 ADCY9	1.53e-04	10	34	2	53
GeneFamily	Olfactory receptors, family 51	OR51E2 OR51Q1	3.09e-03	44	34	2	164
GeneFamily	Olfactory receptors, family 10	OR10H5 OR10J3	6.83e-03	66	34	2	157
Drug	AC1L1E2H	LGR5 IL2 ADCY8 ADCY9	2.35e-06	55	39	4	CID000002612
Drug	AC1Q3G0K	SERINC3 TREH ADCY8 ADCY9	3.34e-06	60	39	4	CID000002087
Drug	cimetidine	LGR5 IL2 ADCY8 ADCY9 SLCO1A2	1.32e-05	179	39	5	CID000002756
Drug	2,4-dinitrophenol	TREH ADCY8 ADCY9 SLC35A1	1.69e-05	90	39	4	CID000001493
Drug	adenosine 3',5'-cyclic phosphate	MC4R MC5R MAPK10 GRM4 IL2 TREH BDKRB2 ADCY8 ADCY9	1.75e-05	907	39	9	CID000000274
Drug	phorbol-13-acetate	MAPK10 IL2 TREH ADCY8 ADCY9 DYRK2	1.80e-05	326	39	6	CID000499953
Drug	Sulpiride [15676-16-1]; Down 200; 11.8uM; PC3; HT_HG-U133A	DOCK10 TRMT11 AGPAT5 STAG1 LGR5	1.89e-05	193	39	5	4566_DN
Drug	1q1m	MC4R MC5R BDKRB2	2.23e-05	32	39	3	CID000447994
Drug	Depixol	IL2 ADCY8 ADCY9	2.45e-05	33	39	3	CID000017011
Drug	AC1L63MU	MAPK10 GRM4 IL2 BDKRB2 ADCY8 ADCY9	2.56e-05	347	39	6	CID000285703
Drug	betamethasone butyrate propionate	MAPK10 IL2	2.85e-05	5	39	2	CID000071470
Drug	HA1004	IL2 TREH ADCY8 ADCY9	3.59e-05	109	39	4	CID000003546
Drug	1iiq	MC4R MAPK10 ADCY8 ADCY9	4.14e-05	113	39	4	CID000446293
Drug	AC1MBZ1C	MC4R MC5R SLC34A1 TREH ADCY8 ADCY9	4.71e-05	387	39	6	CID000003541
Drug	procaterol	IL2 ADCY8 ADCY9	7.62e-05	48	39	3	CID000004916
Drug	AC1L1EV8	ADCY8 ADCY9	7.95e-05	8	39	2	CID000002964
Drug	cyclophorine	IL2 BDKRB2 ADCY8 ADCY9 SLCO1A2 SLC35A1	8.01e-05	426	39	6	CID000002909
Drug	8-bromo-cAMP	MC4R MC5R IL2 ADCY8 ADCY9	8.42e-05	264	39	5	CID000001912
Drug	calphostin C	MAPK10 GRM4 TREH BDKRB2 ADCY8 ADCY9	8.54e-05	431	39	6	CID000002533
Drug	Laevuflex	MAPK10 SLC34A1 TREH ADCY8 ADCY9	9.69e-05	272	39	5	CID000003426
Drug	AC1L1EKQ	GRM4 ADCY8 ADCY9	9.69e-05	52	39	3	CID000002834
Drug	THC, delta 9	IL2 BDKRB2 ADCY8 ADCY9	1.01e-04	142	39	4	CID000002978
Drug	14,15-dihydroforskolin	ADCY8 ADCY9	1.02e-04	9	39	2	CID000194193
Drug	EN-1530	GRM4 IL2 TREH ADCY8 ADCY9	1.07e-04	278	39	5	CID000004425
Drug	saccharin	IL2 ADCY8 ADCY9	1.08e-04	54	39	3	CID000005143
Drug	methylxanthine	IL2 ADCY8 ADCY9	1.21e-04	56	39	3	CID000068374
Drug	isocycloheximide	MC4R MC5R MAPK10 IL2 COL21A1 TREH ADCY8 ADCY9	1.24e-04	905	39	8	CID000002900
Drug	2',5'-dd3'-FSBA	ADCY8 ADCY9	1.28e-04	10	39	2	CID003081206
Drug	NC-5Z	ADCY8 ADCY9	1.28e-04	10	39	2	CID003035914
Drug	indole	MC4R MC5R	1.28e-04	10	39	2	ctd:C030374
Drug	Lys-pro-val	MC4R MC5R	1.28e-04	10	39	2	CID000125672
Drug	NSC-4928	ADCY8 ADCY9 SLCO1A2	1.34e-04	58	39	3	CID000221086
Drug	morphine hydrochloride	MC4R MAPK10 GRM4 IL2 ADCY8 ADCY9	1.56e-04	481	39	6	CID000004253
Drug	AC1NY9KD	ADCY8 ADCY9	1.56e-04	11	39	2	CID005771741
Drug	AC1L40QM	ADCY8 ADCY9	1.56e-04	11	39	2	CID000099213
Drug	B-Mlvp	ADCY8 ADCY9	1.56e-04	11	39	2	CID000195648
Drug	calmidazolium chloride	ADCY8 ADCY9 SLCO1A2 MIP	1.59e-04	160	39	4	CID000002531
Drug	naphthalene-diisocyanate	ADCY8 ADCY9 MIP	1.64e-04	62	39	3	CID003033874
Drug	FCE 23884	ADCY8 ADCY9	2.20e-04	13	39	2	CID000065898
Drug	AC1L1BJN	ADCY8 ADCY9	2.20e-04	13	39	2	CID000001467
Drug	nantradol hydrochloride	ADCY8 ADCY9	2.20e-04	13	39	2	CID000047652
Drug	sclareol glycol	ADCY8 ADCY9	2.20e-04	13	39	2	CID000091915
Drug	AC1L18QD	MAPK10 COL21A1 BDKRB2 ADCY8 ADCY9	2.22e-04	325	39	5	CID000000213
Drug	fenoldopam	SLC34A1 ADCY8 ADCY9	2.35e-04	70	39	3	CID000003340
Drug	AC1NE3N8	MAPK10 IL2 ADCY8 ADCY9	2.40e-04	178	39	4	CID004636050
Drug	sulprostone	BDKRB2 ADCY8 ADCY9	2.45e-04	71	39	3	CID005312153
Drug	forskolin from Coleus forskohlii	MC4R MC5R MAPK10 GRM4 IL2 TREH ADCY8 ADCY9	2.68e-04	1013	39	8	CID000003413
Drug	p,p'-DDA	SERINC3 ADCY8 ADCY9	2.77e-04	74	39	3	CID000006730
Drug	AC1NPJ0Q	IL2 ADCY8 ADCY9	2.77e-04	74	39	3	CID005159167
Drug	Ts-I	OR51E2 ADCY8 ADCY9	2.88e-04	75	39	3	CID000445278
Drug	AC1L1KC5	TPCN2 MAPK10 GRM4 IL2 BDKRB2 ADCY9	2.93e-04	541	39	6	CID000005428
Drug	SKF 75670	ADCY8 ADCY9	2.96e-04	15	39	2	CID000173870
Drug	BMY 42393	ADCY8 ADCY9	2.96e-04	15	39	2	CID000131961
Drug	AC1L2AAS	ADCY8 ADCY9	2.96e-04	15	39	2	CID000068714
Drug	butaprost	BDKRB2 ADCY8 ADCY9	3.23e-04	78	39	3	CID005311035
Drug	R-5	MC4R MC5R	3.38e-04	16	39	2	CID011742733
Drug	chelerythrine	GRM4 SLC34A1 BDKRB2 ADCY8 ADCY9	3.42e-04	357	39	5	CID000002703
Drug	buspirone	IL2 ADCY8 ADCY9	3.48e-04	80	39	3	CID000002477
Drug	terbutaline	IL2 ADCY8 ADCY9	3.48e-04	80	39	3	CID000005403
Drug	Betamethasone-d5	MC4R MC5R MAPK10 IL2 SLC34A1 COL21A1 TREH ADCY8 ADCY9	3.50e-04	1340	39	9	CID000003003
Drug	Tremorine dihydrochloride [300-68-5]; Up 200; 15uM; MCF7; HT_HG-U133A	IL2 COL21A1 SLCO1A2 MIP	3.53e-04	197	39	4	3196_UP
Drug	Nicergoline; Up 200; 8.2uM; PC3; HT_HG-U133A	DUSP21 GRM4 LGR5 ADCY9	3.53e-04	197	39	4	5775_UP
Drug	Roxarsone [121-19-7]; Up 200; 15.2uM; PC3; HT_HG-U133A	DOCK10 MAPK10 COL21A1 ADCY9	3.53e-04	197	39	4	5051_UP
Drug	Famprofazone [22881-35-2]; Up 200; 10.6uM; MCF7; HT_HG-U133A	MC5R DUSP21 GRM4 MIP	3.60e-04	198	39	4	3928_UP
Drug	Mafenide hydrochloride [138-37-4]; Up 200; 18uM; PC3; HT_HG-U133A	MC5R GRM4 COL21A1 DYRK2	3.67e-04	199	39	4	5079_UP
Drug	PF-00539758-00 [351321-34-1]; Down 200; 10uM; PC3; HT_HG-U133A	DNAH3 GRM4 COL21A1 MIP	3.67e-04	199	39	4	6379_DN
Drug	Propylthiouracil [51-52-5]; Up 200; 23.4uM; HL60; HT_HG-U133A	MAPK10 IL2 ADCY9 SLCO1A2	3.67e-04	199	39	4	2476_UP
Drug	DPDPE	ADCY8 ADCY9 SLCO1A2	3.75e-04	82	39	3	CID000104787
Drug	D-myo-inositol-1,4,5-triphosphate	TPCN2 MAPK10 GRM4 BDKRB2 ADCY8 ADCY9	3.80e-04	568	39	6	CID000000806
Drug	Hp 228	MC4R IL2	3.83e-04	17	39	2	CID000130595
Drug	U754	ADCY8 ADCY9	3.83e-04	17	39	2	CID000062824
Drug	fentanyl isothiocyanate	ADCY8 ADCY9	3.83e-04	17	39	2	CID000084008
Drug	San 21009	ADCY8 ADCY9	3.83e-04	17	39	2	CID000152662
Drug	amphotericin B solution	COL21A1 ADCY8 ADCY9	4.02e-04	84	39	3	CID000001972
Drug	isocaproaldehyde	MC4R MC5R	4.30e-04	18	39	2	CID000000129
Drug	esmolol	SERINC3 IL2	4.30e-04	18	39	2	CID000059768
Drug	AC1LD8Z3	ADCY8 ADCY9 SLCO1A2	4.31e-04	86	39	3	CID000644309
Drug	trans-permethrin	ADCY8 ADCY9 DYRK2	4.31e-04	86	39	3	CID000040159
Drug	phosphoenolpyruvate	TREH ADCY8 ADCY9 SLC35A1	4.49e-04	210	39	4	CID000001005
Drug	metolachlor	SERINC3 DUSP21 DYRK2	4.61e-04	88	39	3	CID000004169
Drug	Ro 41-9067	ADCY8 ADCY9	4.80e-04	19	39	2	CID000125800
Drug	AC1L3XQA	ADCY8 ADCY9	4.80e-04	19	39	2	CID000124009
Drug	R-4	MC4R MC5R	4.80e-04	19	39	2	CID009800976
Drug	SK&F 82958	ADCY8 ADCY9	4.80e-04	19	39	2	ctd:C071262
Drug	2-amino-4-phosphonobutyric acid	GRM4 ADCY8 ADCY9	5.09e-04	91	39	3	CID000002207
Drug	Dvdavp	ADCY8 ADCY9	5.33e-04	20	39	2	CID006441676
Drug	YM435	ADCY8 ADCY9	5.33e-04	20	39	2	CID000132119
Drug	4pal	MC4R MC5R	5.33e-04	20	39	2	CID005748175
Drug	AC1L1UOQ	MC4R MC5R	5.33e-04	20	39	2	CID000010197
Drug	haloperidol	GRM4 IL2 COL21A1 ADCY8 ADCY9	5.37e-04	394	39	5	CID000003559
Drug	Acth (4-10)	MC4R MC5R	5.88e-04	21	39	2	CID000123787
Drug	6-fluoronorepinephrine	ADCY8 ADCY9	5.88e-04	21	39	2	CID000001862
Drug	reproterol	ADCY8 ADCY9	5.88e-04	21	39	2	CID000025654
Drug	N-arachidonoylethanolamine	MC4R MAPK10 ADCY8 ADCY9	5.92e-04	226	39	4	CID000002185
Drug	IC261	DNAH3 MAPK10 BDKRB2	5.95e-04	96	39	3	CID000003674
Drug	delta-(l-alpha-aminoadipoyl)-l-cysteinyl-glycine	LGR5 IL2 ADCY8 ADCY9	6.22e-04	229	39	4	CID004369448
Drug	BCNU	MAPK10 IL2 TREH SLCO1A2	6.22e-04	229	39	4	CID000002578
Drug	GSK835726	ADCY8 ADCY9	6.46e-04	22	39	2	CID005311268
Drug	oxychlordane	MC5R SERINC3	6.46e-04	22	39	2	CID000033772
Drug	Acth(11-24)	MC4R MC5R	6.46e-04	22	39	2	CID003037130
Disease	fish oil supplement exposure measurement, high density lipoprotein cholesterol measurement	INTS10 GRM4	2.86e-05	7	35	2	EFO_0004612, EFO_0600007
Disease	dental caries, dentures	MC4R STAG1 ADCY8	7.92e-05	70	35	3	EFO_0003819, EFO_0010078
Disease	dentures	MC4R STAG1 ADCY8	7.92e-05	70	35	3	EFO_0010078
Disease	phospholipids:total lipids ratio	INTS10 STAG1 SLC34A1 MADD	1.48e-04	227	35	4	EFO_0020946
Disease	cigarettes per day measurement	MC4R INTS10 STAG1 GRM4 ADCY8	1.58e-04	438	35	5	EFO_0006525
Disease	Colorectal Carcinoma	OR1E2 DNAH3 DUSP21 LGR5 ADCY8 SLCO1A2	1.60e-04	702	35	6	C0009402
Disease	nervousness	MC4R MADD	1.62e-04	16	35	2	NCIT_C74532
Disease	breast carcinoma	MC4R INTS10 TPCN2 MAPK10 ADCY8 ADCY9 MADD	1.65e-04	1019	35	7	EFO_0000305
Disease	asthma, response to diisocyanate	OR10J3 ADCY8 ADCY9 SLCO1A2	2.52e-04	261	35	4	EFO_0006995, MONDO_0004979
Disease	Hemorrhage	BDKRB2 SLC35A1	2.56e-04	20	35	2	C0019080
Disease	Glioblastoma Multiforme	TRMT11 IL2 DYRK2	3.11e-04	111	35	3	C1621958
Disease	physical activity measurement, body mass index	MC4R ADCY8 ADCY9	3.36e-04	114	35	3	EFO_0004340, EFO_0008002
Disease	Epilepsy, Benign Psychomotor, Childhood	GRM4 BDKRB2	3.40e-04	23	35	2	C0393672
Disease	Epilepsy, Lateral Temporal	GRM4 BDKRB2	3.40e-04	23	35	2	C0393682
Disease	Uncinate Epilepsy	GRM4 BDKRB2	3.40e-04	23	35	2	C0014558
Disease	Epilepsy, Temporal Lobe	GRM4 BDKRB2	3.40e-04	23	35	2	C0014556
Disease	sex interaction measurement, body mass index, age at assessment	MC4R ADCY8	3.40e-04	23	35	2	EFO_0004340, EFO_0008007, EFO_0008343
Disease	rhinitis (is_implicated_in)	IL2 BDKRB2	5.82e-04	30	35	2	DOID:4483 (is_implicated_in)
Disease	progressive supranuclear palsy	IL2 SLCO1A2	6.22e-04	31	35	2	MONDO_0019037
Disease	Hyperkinesia, Generalized	IL2 ADCY8	6.63e-04	32	35	2	C0751217
Disease	Hyperkinesia	IL2 ADCY8	6.63e-04	32	35	2	C3887506
Disease	brain infarction (biomarker_via_orthology)	TPCN2 IL2	7.05e-04	33	35	2	DOID:3454 (biomarker_via_orthology)
Disease	obese body mass index status	MC4R ADCY8	7.05e-04	33	35	2	EFO_0007041
Disease	C-reactive protein measurement, high density lipoprotein cholesterol measurement	MC4R STAG1	7.49e-04	34	35	2	EFO_0004458, EFO_0004612
Disease	comparative body size at age 10, self-reported	MC4R COL21A1 ADCY8 ADCY9	1.49e-03	420	35	4	EFO_0009819
Disease	Pain, Migratory	IL2 BDKRB2	1.55e-03	49	35	2	C0751407
Disease	Suffering, Physical	IL2 BDKRB2	1.55e-03	49	35	2	C0751408
Disease	Pain, Crushing	IL2 BDKRB2	1.55e-03	49	35	2	C0458259
Disease	Pain, Splitting	IL2 BDKRB2	1.55e-03	49	35	2	C0458257
Disease	Pain	IL2 BDKRB2	1.55e-03	49	35	2	C0030193
Disease	Radiating pain	IL2 BDKRB2	1.55e-03	49	35	2	C0234254
Disease	Pain, Burning	IL2 BDKRB2	1.55e-03	49	35	2	C0234230
Disease	Ache	IL2 BDKRB2	1.55e-03	49	35	2	C0234238
Disease	mammographic density measurement	MAPK10 ADCY8	1.62e-03	50	35	2	EFO_0005941
Disease	body mass index, fasting blood glucose measurement	ADCY9 MADD	1.68e-03	51	35	2	EFO_0004340, EFO_0004465
Disease	sexual dimorphism measurement	MC4R INTS10 GRM4 ADCY8 ADCY9 MADD	1.75e-03	1106	35	6	EFO_0021796
Disease	Hypotension	IL2 BDKRB2	1.81e-03	53	35	2	C0020649
Disease	cholesterol to total lipids in large HDL percentage	INTS10 MADD	1.95e-03	55	35	2	EFO_0022234
Disease	blood urea nitrogen measurement	TPCN2 STAG1 SLC34A1 MIP	1.95e-03	452	35	4	EFO_0004741
Disease	triglycerides to total lipids in large HDL percentage	INTS10 MADD	2.32e-03	60	35	2	EFO_0022330

Protein segments in the cluster

Peptide	Gene	Start	Entry
SLLLMAMFLLAVFYH	ADCY8	901	P40145
IISMNLYSSICFLML	BDKRB2	136	P30411
LSLICLLGYSMLLMV	GRM4	751	Q14833
MSLLRAFCYMAAQLL	MIP	81	P30301
TSKAIMPYCLHLMLA	INTS10	556	Q9NVR2
VSYMLILLAICQMHS	OR8K5	216	Q8NH50
HMPMYLFLCALSITE	OR10H5	56	Q8NGA6
FLLSHLSLIDMMYIS	OR2T1	111	O43869
HYLTIMSPRMCLSFL	OR4F21	131	O95013
LATLLHNLISYMLLM	MADD	1371	Q8WXG6
MSYLLYQMLCGIKHL	MAPK10	166	P53779
LCMLLDFVSMLVVYH	GPR158	426	Q5T848
ERSLHAPMYLFLCML	OR51E2	51	Q9H255
SVHQRMYLFLSMLAL	OR51Q1	56	Q8NH59
LILMDSCLHTPMYFF	OR5B2	46	Q96R09
LMLTFLYLFVCSLDM	SLC34A1	106	Q06495
MYRMQLLSCIALSLA	IL2	1	P60568
SLLMCFLHIMKTISY	DOCK10	1336	Q96BY6
IHLAFSMMRLYSSLL	DNAH3	1911	Q8TD57
MAHYITFLCMVLVLL	COL21A1	1	Q96P44
MCIEVLFLLYTVMHL	ADCY9	226	O60503
MSHFNLYLILIMCNS	MC4R	281	P32245
AMLFLLVSLYIHMFL	MC5R	196	P33032
HICMTFELLSMNLYE	DYRK2	296	Q92630
LCLAYLMKYHSMSLL	DUSP21	116	Q9H596
LLNSLCFLMMTIAYT	LGR5	731	O75473
CFLLHYTAIMSPMLC	OR1E2	136	P47887
SDMQLLLHGLFLSMY	OR7C2	21	O60412
LHTPMYFFLCMLSIS	OR10J3	56	Q5JRS4
HYLTIMSPRMCLSFL	OR4F3;	131	Q6IEY1
LFKLYCLAVMTLMAA	SLC35A1	11	P78382
MALSCTLNRYLLLMA	TRMT11	1	Q7Z4G4
CSLMLQYFLILSAMS	SLCO1A2	506	P46721
IMALMNTLLYLCLDH	POMK	26	Q9H5K3
LKHSHCALERLMLMY	NLRP9	766	Q7RTR0
LLTLMMDCYLTHTND	TREH	226	O43280
AFMLLCDLLMIFSHQ	STAG1	791	Q8WVM7
SLFHLMLCLASLYIM	SERINC3	406	Q13530
MLLSLVLHTYSMRYL	AGPAT5	1	Q9NUQ2
LLLAIHLCLFTMFGM	TPCN2	221	Q8NHX9