Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainG8

CEMIP2 CEMIP

4.37e-054512PF10162
DomainG8_domain

CEMIP2 CEMIP

4.37e-054512IPR019316
DomainG8

CEMIP2 CEMIP

4.37e-054512PS51484
DomainG8

CEMIP2 CEMIP

4.37e-054512SM01225
DomainWD40_repeat_dom

WDR6 NBEAL2 HERC1 HPS5 DENND3 WDR24

1.52e-04297516IPR017986
DomainPectin_lyase_fold/virulence

CEMIP2 CEMIP

2.03e-048512IPR011050
Domain-

WDR6 NBEAL2 HERC1 HPS5 DENND3 WDR24

2.81e-043335162.130.10.10
DomainWD40/YVTN_repeat-like_dom

WDR6 NBEAL2 HERC1 HPS5 DENND3 WDR24

2.91e-04335516IPR015943
DomainHotDog_dom

ACOT8 ACOT11

3.24e-0410512IPR029069
Domain-

ACOT8 ACOT11

3.24e-04105123.10.129.10
DomainWD40

WDR6 NBEAL2 HERC1 DENND3 WDR24

6.89e-04259515PF00400
DomainWD40

WDR6 NBEAL2 HERC1 DENND3 WDR24

8.03e-04268515SM00320
DomainWD40_repeat

WDR6 NBEAL2 HERC1 DENND3 WDR24

8.58e-04272515IPR001680
DomainWD_REPEATS_1

WDR6 NBEAL2 HERC1 DENND3 WDR24

9.46e-04278515PS00678
DomainWD_REPEATS_2

WDR6 NBEAL2 HERC1 DENND3 WDR24

9.62e-04279515PS50082
DomainWD_REPEATS_REGION

WDR6 NBEAL2 HERC1 DENND3 WDR24

9.62e-04279515PS50294
Pubmed

Concurrent Overexpression of Two Hyaluronidases, KIAA1199 and TMEM2, Strongly Predicts Shorter Survival After Resection in Pancreatic Ductal Adenocarcinoma.

CEMIP2 CEMIP

2.55e-06256236395406
Pubmed

Expression and regulation of recently discovered hyaluronidases, HYBID and TMEM2, in chondrocytes from knee osteoarthritic cartilage.

CEMIP2 CEMIP

2.55e-06256236241903
Pubmed

The role and regulation of TMEM2 (transmembrane protein 2) in HYBID (hyaluronan (HA)-binding protein involved in HA depolymerization/ KIAA1199/CEMIP)-mediated HA depolymerization in human skin fibroblasts.

CEMIP2 CEMIP

2.55e-06256230241936
Pubmed

Human TMEM2 is not a catalytic hyaluronidase, but a regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2 expression.

CEMIP2 CEMIP

7.63e-06356237196767
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

WDR6 SLTM GAPDHS HPS5 CLEC16A DENND3 CEMIP2 CEMIP

9.19e-0665056838777146
Pubmed

A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis.

RBMY1A1 RBMY1C

5.32e-0575628269511
Pubmed

Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.

PRKAR2B HERC1 HPS5 WDR24

7.64e-0513956425476789
Pubmed

A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases.

ACOT8 ACOT11

9.10e-05956216103133
Pubmed

T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis.

RBMY1A1 RBMY1C

1.14e-041056210332027
Pubmed

Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene.

RBMY1A1 RBMY1C

1.66e-04125629598316
Pubmed

RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.

RBMY1A1 RBMY1C

1.96e-041356210749975
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

VWA5B2 FAM220A MAST1 DNAH7

5.49e-0423356437704626
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

GPR158 MAST1 KATNIP CHD1L ARHGEF37 HPS5 CLEC16A KLHL26 ADSS1

5.81e-04148956928611215
Pubmed

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

MAST1 HPS5 DNAH7

6.06e-0410256310231032
Pubmed

Foxp transcription factors suppress a non-pulmonary gene expression program to permit proper lung development.

PAX2 FOXJ1

8.07e-042656227341756
Pubmed

Retinoic acid deficiency impairs the vestibular function.

OTOP1 PAX2

8.07e-042656223536097
Pubmed

STK11 is required for the normal program of ciliated cell differentiation in airways.

SIK1 FOXJ1

1.15e-033156231636950
Pubmed

Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle.

COX6A2 ADSS1

1.22e-033256217904117
Pubmed

Functional significance of isoform diversification in the protocadherin gamma gene cluster.

PCDHGA10 PAX2

1.38e-033456222884324
GeneFamilyWD repeat domain containing

WDR6 NBEAL2 HERC1 DENND3 WDR24

1.05e-04262335362
GeneFamilyAcyl-CoA thioesterases

ACOT8 ACOT11

1.44e-041033241
GeneFamilyRNA binding motif containing

RBMY1A1 RBMY1C SLTM

6.78e-03213333725
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

C20orf203 ZBTB32 SIK1 CHD1L HERPUD1

3.28e-061855553563dd39ec58d3273f95f5bb36b9ccdc0aafb63a
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gpr149_Islr|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

COX6A2 SPSB4 CEMIP ADSS1

1.79e-051265543539a8fdbb52d191f36dce68c38798ad4d2b491a
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Sema3e_Kank4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

COX6A2 SPSB4 CEMIP ADSS1

2.35e-0513555454b2aaf8d322e01a3ff6099c2422d68ecccf96b4
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Itm2a|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

COX6A2 SPSB4 CEMIP ADSS1

3.02e-051445540bbe670454846cf9bc7464ae4e91488415c4111d
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA5B2 FLG2 CEMIP2 CEMIP

4.03e-051555548fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gpr149_Islr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

COX6A2 SPSB4 CEMIP ADSS1

4.45e-05159554c64fff8d89f84d1f5a0cc432e31f56f741162505
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

COX6A2 SPSB4 CEMIP ADSS1

4.90e-05163554db6b7ce6f7221bb73c5e650ac51cdd5d7ef00675
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Tpbg|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

COX6A2 SPSB4 CEMIP ADSS1

5.02e-05164554f0499e6c1b17c4df72b18b294e3b53ef723da2ac
ToppCellCiliated_cells-A-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

DOC2A VWA5B2 DNAH7 FOXJ1

5.14e-051655540ebdbbdb151fb797335013d5838af1c7bbc45b06
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Tac1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

COX6A2 SPSB4 CEMIP ADSS1

5.26e-0516655459d47c1fca7a8c70f6998f3367a9dbcb9b67966f
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5|TCGA-Ovary / Sample_Type by Project: Shred V9

ACOT11 WDR6 MEPCE KATNIP

5.26e-0516655432d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Tpbg|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

COX6A2 SPSB4 CEMIP ADSS1

5.26e-05166554b4241f8d2a0aa910dbb0d0d5d3631a9b73453fe9
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

COX6A2 SPSB4 CEMIP ADSS1

5.51e-051685542572a3dd4f3f619bd26a3cd6e60de43821d8bb64
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOC2A KATNIP DNAH7 FOXJ1

7.21e-0518055492fb01b91261b3103454924cde56add337b41844
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DOC2A NBEAL2 CHD1L WDR24

7.36e-05181554f6629fa71bb94405f523f63a9264cacf6d15c5f4
ToppCelldroplet-Limb_Muscle-nan-3m-Mesenchymal-skeletal_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COX6A2 CYP4F22 ADPRHL1 ADSS1

7.52e-05182554edfc598b7199ca1d8a399b264ab863c299b1eede
ToppCellnormal-na-Lymphocytic_B-B_atypical-female|normal / PBMC cell types (v2) per disease, treatment status, and sex

ZBTB32 SIK1 HERPUD1 CEMIP2

8.52e-05188554e5ab89030783461e9367ab87c353fb5c31911020
ToppCellnormal-na-Lymphocytic_B-B_atypical|normal / PBMC cell types (v2) per disease, treatment status, and sex

ZBTB32 SIK1 HERPUD1 CEMIP2

8.52e-0518855413653481d64c7a1ad833d738a3ee0bb9def7cec7
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam____podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFE2L3 RBMY1A1 PAX2 FOXJ1

8.70e-05189554319e42f6e2322208de78bc666fb2c074707eb4da
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR158 ACOT11 COX6A2 PRKAR2B

9.06e-05191554f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA5B2 ACOT11 WDR6 HERPUD1

9.06e-05191554a251b134f67a0a1ef3a42f50042f128a17f20b22
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-B_atypical|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ZBTB32 SIK1 HERPUD1 CEMIP2

9.25e-0519255424797e80b1f5b3ea5a0410caaf57ccf2ae9d716e
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-B_atypical-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ZBTB32 SIK1 HERPUD1 CEMIP2

9.62e-05194554b8f05efb16fbed7317019efc3da7f97f81e90972
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

GPR158 MAST1 SLC45A1 HERC1

9.62e-051945548aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCellControl_saline-Epithelial_alveolar-AT_1-Differentiating_AT1|Control_saline / Treatment groups by lineage, cell group, cell type

NBEAL2 SIK1 HPS5 DENND3

1.04e-0419855485f424cd9bb3117c9e322031024aabb87696ce47
DiseaseHDL cholesterol change measurement, response to statin

HERPUD1 CEMIP

9.49e-063532EFO_0007805, GO_0036273
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

NFE2L3 HERPUD1

1.71e-0334532EFO_0008317, EFO_0008596, EFO_0020944
Diseaseplatelet measurement

LDLRAP1 NBEAL2 SIGLEC11 GAPDHS

2.47e-03315534EFO_0005036
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

NFE2L3 HERPUD1

3.11e-0346532EFO_0008317, EFO_0008596, EFO_0020943
Diseasecholesteryl esters to total lipids in small VLDL percentage

NFE2L3 HERPUD1

3.53e-0349532EFO_0022256

Protein segments in the cluster

PeptideGeneStartEntry
GGSRGLVHGRLWRQD

ACOT8

281

O14734
KTRGWHSPGRGSLDE

CATSPERZ

61

Q9NTU4
LVSRGLGRGWHAGLC

FAM228A

181

Q86W67
LTQDRGGHGATGGWK

ADGRB1

251

O14514
TKGNSGRWLVDTGGH

ARHGEF37

541

A1IGU5
WGGAGAEKTRPGSRH

C20orf204

51

A0A1B0GTL2
RKDPSGAGLWLHSGG

FAM220A

66

Q7Z4H9
GRRSDGWNGKLAGGH

ACOT11

571

Q8WXI4
RGGLTSIRLHGGRLW

DENND3

1031

A2RUS2
DNRIWGPGGLDHSGR

CEMIP

851

Q8WUJ3
RGGTRGWLPSHEGHL

RBMY1A1

116

P0DJD3
RGGTRGWLPSHEGHL

RBMY1C

116

P0DJD4
LSGDRGWSVGHLKAH

HERPUD1

26

Q15011
GGGGRWKALLGRHQA

NSUN5

86

Q96P11
SLAKQSWGGGGRHRK

LDLRAP1

16

Q5SW96
GSGSNSWERKGHGGL

FLG2

226

Q5D862
QGSKEKGRGSWGGRH

MEPCE

381

Q7L2J0
LGHSWRRKDGLGGDK

GPR158

246

Q5T848
KGLRHEPGWGTSRSV

KATNIP

806

O60303
LWGAGRHGQLAEAGR

HERC1

4001

Q15751
AVSRKWLALGSSGGG

HPS5

41

Q9UPZ3
RIRHDGKGSGSGWYL

LOXHD1

621

Q8IVV2
HLWDLGGGAGRRTSK

C20orf203

56

Q8NBC4
RRWHKSRLLQASGGG

PCDHGA10

721

Q9Y5H3
GGWGRAGHLHPKGRE

NFE2L3

66

Q9Y4A8
RGAGWTGHVAGTRKT

QPRT

126

Q15274
LGGLTLREKTWRGGS

MAST1

756

Q9Y2H9
RGGGGLHLVWTLRDV

PAX2

216

Q02962
FRLKDTHAGAGWLRG

OTOP1

121

Q7RTM1
LKRRTWGHAGAASGG

KLHL26

446

Q53HC5
SLGPGARGEARKHWS

DOC2A

356

Q14183
AKGGHGGAGARTWRL

COX6A2

16

Q02221
DDSGHWGRGGLFTAL

CHD1L

741

Q86WJ1
GGLGGEKTRWSHTAL

DNAH7

2881

Q8WXX0
AGWGAGEGRLGHKRK

FOXJ1

261

Q92949
RKWSSEGRGGRRGHD

ADPRHL1

261

Q8NDY3
AGGTLELHGARKASW

CEMIP2

226

Q9UHN6
KGTARFGHEGRTWGD

PRKAR2B

46

P31323
WLEGGSLLGAARHGD

FKRP

341

Q9H9S5
DGPSRKAWRDGRGAH

GAPDHS

261

O14556
HWDKTGFGRALGGQL

SLC45A1

286

Q9Y2W3
GDGLLLSKGDKWSRH

CYP4F22

141

Q6NT55
GHEWGVTTGRKRRCG

ADSS1

326

Q8N142
GKLLFSGGHWDGSLR

NBEAL2

2471

Q6ZNJ1
RHGRDTSGPRKEWHG

SLTM

956

Q9NWH9
GLHGGAAGSREGWSL

SIK1B

636

A0A0B4J2F2
GLHGGAAGSREGWSL

SIK1

636

P57059
NRALGSSWLGGEKRS

CHST13

36

Q8NET6
RSWVGGGHGKTSRNI

CLEC16A

6

Q2KHT3
GASRGWRSRHQLKGR

TP53TG5

266

Q9Y2B4
LAWDPRKLRGNGSGH

ZC3H6

781

P61129
GIRGKVGHARGLHAW

SPSB4

86

Q96A44
GGDDSGIRLWHLVGR

WDR6

316

Q9NNW5
GLGGTDLRGRTWATA

VWA5B2

1156

Q8N398
GQRGADGKHGVLTWL

ZBTB32

201

Q9Y2Y4
HPEDRGWLATGGRDK

WDR24

216

Q96S15
WRILSGKGSGGSARA

nan

26

Q6ZTI0
HGGLSSGLRLRCKAW

SIGLEC11

521

Q96RL6