Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncytoskeletal protein binding

GPHN FLNA FLNB DLG5 KLHL1 EML4 APC2 DYRK1A GBP1 CLSTN2 ACTR3B SHROOM2 EML3 RAB10 TIAM1 KIF3C PLEKHH2 SCIN

9.06e-06109910118GO:0008092
GeneOntologyMolecularFunctionacetate-CoA ligase activity

DIP2A ACSS3

1.51e-0441012GO:0003987
GeneOntologyMolecularFunctioncadherin binding

DAB2IP FLNA FLNB SEPTIN9 LARP1 RAB10 AHNAK CDH4

3.26e-043391018GO:0045296
GeneOntologyMolecularFunctionbeta-catenin binding

SETD1A DLG5 APC2 SHROOM2 CDH4

3.60e-041201015GO:0008013
GeneOntologyCellularComponentdendrite

DAB2IP GPHN FLNA KLHL1 DYRK1A CLSTN2 GRIK5 DIP2A IGF2BP1 SLC8A3 TIAM1 CPEB4 XRN1 LRP1 DLG3 KIF3C ATP2B1

8.23e-0785810217GO:0030425
GeneOntologyCellularComponentdendritic tree

DAB2IP GPHN FLNA KLHL1 DYRK1A CLSTN2 GRIK5 DIP2A IGF2BP1 SLC8A3 TIAM1 CPEB4 XRN1 LRP1 DLG3 KIF3C ATP2B1

8.50e-0786010217GO:0097447
GeneOntologyCellularComponentanchoring junction

JCAD FLNA FLNB DLG5 CDC42BPA PCDHB5 LCP2 SHROOM2 RAB10 SLC8A3 HMCN1 TIAM1 AHNAK LRP1 DLG3 SCIN CDH4 RPL8

1.05e-0697610218GO:0070161
GeneOntologyCellularComponentsomatodendritic compartment

DAB2IP GPHN FLNA FLNB KLHL1 DYRK1A CLSTN2 GRIK5 SHROOM2 TXNRD1 DIP2A IGF2BP1 SLC8A3 TIAM1 CPEB4 XRN1 LRP1 DLG3 KIF3C ATP2B1

1.69e-06122810220GO:0036477
GeneOntologyCellularComponentcell body

DAB2IP GPHN FLNA FLNB KLHL1 GRIK5 SHROOM2 TXNRD1 IGF2BP1 SLC8A3 TIAM1 XRN1 LRP1 DLG3 KIF3C ATP2B1 ALK

2.43e-0692910217GO:0044297
GeneOntologyCellularComponentneuronal cell body

DAB2IP GPHN FLNA FLNB KLHL1 GRIK5 SHROOM2 TXNRD1 IGF2BP1 SLC8A3 TIAM1 XRN1 LRP1 DLG3 KIF3C ATP2B1

2.77e-0683510216GO:0043025
GeneOntologyCellularComponentcell-cell junction

JCAD FLNA DLG5 CDC42BPA PCDHB5 LCP2 SHROOM2 RAB10 HMCN1 TIAM1 AHNAK DLG3 CDH4

6.04e-0659110213GO:0005911
GeneOntologyCellularComponentpostsynaptic density

GPHN DLG5 CLSTN2 GRIK5 SLC8A3 TIAM1 CPEB4 LRP1 DLG3 RPL8

7.18e-0545110210GO:0014069
GeneOntologyCellularComponentadherens junction

JCAD DLG5 SHROOM2 RAB10 HMCN1 DLG3 CDH4

8.17e-052121027GO:0005912
GeneOntologyCellularComponentasymmetric synapse

GPHN DLG5 CLSTN2 GRIK5 SLC8A3 TIAM1 CPEB4 LRP1 DLG3 RPL8

1.14e-0447710210GO:0032279
GeneOntologyCellularComponentactin cytoskeleton

FLNA FLNB CDC42BPA SEPTIN9 APC2 DYRK1A GBP1 SHROOM2 AHNAK PLEKHH2 SCIN

1.17e-0457610211GO:0015629
GeneOntologyCellularComponentpostsynapse

GPHN FLNA DLG5 APC2 CLSTN2 GRIK5 DIP2A IGF2BP1 SLC8A3 TIAM1 CPEB4 LRP1 DLG3 ATP2B1 RPL8

1.22e-04101810215GO:0098794
GeneOntologyCellularComponentpostsynaptic specialization

GPHN DLG5 CLSTN2 GRIK5 SLC8A3 TIAM1 CPEB4 LRP1 DLG3 RPL8

1.75e-0450310210GO:0099572
GeneOntologyCellularComponentgrowth cone

FLNA IGF2BP1 TIAM1 CPEB4 LRP1 DLG3 KIF3C

2.00e-042451027GO:0030426
GeneOntologyCellularComponentneuron to neuron synapse

GPHN DLG5 CLSTN2 GRIK5 SLC8A3 TIAM1 CPEB4 LRP1 DLG3 RPL8

2.40e-0452310210GO:0098984
GeneOntologyCellularComponentsite of polarized growth

FLNA IGF2BP1 TIAM1 CPEB4 LRP1 DLG3 KIF3C

2.43e-042531027GO:0030427
GeneOntologyCellularComponentmicrotubule

EML4 SEPTIN9 APC2 DYRK1A SHROOM2 EML3 SLC8A3 TIAM1 KIF3C CFAP53

2.79e-0453310210GO:0005874
GeneOntologyCellularComponentdistal axon

FLNA GRIK5 IGF2BP1 SLC8A3 TIAM1 CPEB4 LRP1 DLG3 KIF3C

2.80e-044351029GO:0150034
GeneOntologyCellularComponentpostsynaptic specialization membrane

GPHN CLSTN2 GRIK5 TIAM1 LRP1 DLG3

4.59e-042011026GO:0099634
GeneOntologyCellularComponentcell cortex

FLNA FLNB SEPTIN9 SHROOM2 RAB10 HMCN1 PLEKHH2 SCIN

4.69e-043711028GO:0005938
GeneOntologyCellularComponentfibrillar center

SELENBP1 POLR1G TXNRD1 POLR1E KDM4A

1.01e-031561025GO:0001650
GeneOntologyCellularComponentpostsynaptic density membrane

CLSTN2 GRIK5 TIAM1 LRP1 DLG3

1.04e-031571025GO:0098839
GeneOntologyCellularComponentdendritic spine

DIP2A IGF2BP1 SLC8A3 TIAM1 CPEB4 ATP2B1

1.21e-032421026GO:0043197
GeneOntologyCellularComponentinsulin-responsive compartment

RAB10 LRP1

1.26e-03111022GO:0032593
GeneOntologyCellularComponentaxon

DAB2IP FLNA DYRK1A GRIK5 IGF2BP1 SLC8A3 TIAM1 CPEB4 LRP1 DLG3 KIF3C ALK

1.33e-0389110212GO:0030424
GeneOntologyCellularComponentneuron spine

DIP2A IGF2BP1 SLC8A3 TIAM1 CPEB4 ATP2B1

1.34e-032471026GO:0044309
GeneOntologyCellularComponentaxonal growth cone

FLNA TIAM1 LRP1

1.38e-03451023GO:0044295
GeneOntologyCellularComponentsupramolecular fiber

FLNA FLNB EML4 SEPTIN9 APC2 DYRK1A SHROOM2 EML3 SLC8A3 TIAM1 AHNAK KIF3C CFAP53 AHNAK2

1.74e-03117910214GO:0099512
GeneOntologyCellularComponentRNA polymerase I complex

POLR1G POLR1E

1.78e-03131022GO:0005736
GeneOntologyCellularComponentsupramolecular polymer

FLNA FLNB EML4 SEPTIN9 APC2 DYRK1A SHROOM2 EML3 SLC8A3 TIAM1 AHNAK KIF3C CFAP53 AHNAK2

1.85e-03118710214GO:0099081
GeneOntologyCellularComponentperinuclear region of cytoplasm

JCAD FLNA SEPTIN9 APC2 GBP1 RAB40A RAB10 IGF2BP1 SLC8A3 CPEB4 RAB40AL LRP1

1.98e-0393410212GO:0048471
GeneOntologyCellularComponentpostsynaptic membrane

GPHN CLSTN2 GRIK5 SLC8A3 TIAM1 LRP1 DLG3

3.71e-034051027GO:0045211
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

FLNA EML4 SEPTIN9 APC2 DYRK1A SHROOM2 EML3 SLC8A3 TIAM1 KIF3C CFAP53

4.41e-0389910211GO:0099513
GeneOntologyCellularComponentextrinsic component of plasma membrane

GPHN APC2 TIAM1 CDH4

4.57e-031371024GO:0019897
GeneOntologyCellularComponentcostamere

AHNAK AHNAK2

5.11e-03221022GO:0043034
DomainPDZ

DLG5 RAPGEF6 SHROOM2 TIAM1 AHNAK DLG3 AHNAK2

1.07e-051411007PF00595
DomainPDZ

DLG5 RAPGEF6 SHROOM2 TIAM1 AHNAK DLG3 AHNAK2

1.47e-051481007SM00228
Domain-

DLG5 RAPGEF6 SHROOM2 TIAM1 AHNAK DLG3 AHNAK2

1.61e-0515010072.30.42.10
DomainPDZ

DLG5 RAPGEF6 SHROOM2 TIAM1 AHNAK DLG3 AHNAK2

1.68e-051511007PS50106
DomainPDZ

DLG5 RAPGEF6 SHROOM2 TIAM1 AHNAK DLG3 AHNAK2

1.75e-051521007IPR001478
DomainHELP

EML4 EML3

4.20e-0461002PF03451
DomainHELP

EML4 EML3

4.20e-0461002IPR005108
DomainCadherin

PCDHB5 PCDHB4 CLSTN2 FREM1 CDH4

4.31e-041181005IPR002126
DomainCalx_beta

FREM1 SLC8A3

9.97e-0491002IPR003644
DomainCalx-beta

FREM1 SLC8A3

9.97e-0491002PF03160
DomainIG_FLMN

FLNA FLNB

1.24e-03101002SM00557
DomainFilamin

FLNA FLNB

1.51e-03111002PF00630
DomainFILAMIN_REPEAT

FLNA FLNB

1.51e-03111002PS50194
DomainFilamin/ABP280_rpt

FLNA FLNB

1.51e-03111002IPR001298
DomainFilamin/ABP280_repeat-like

FLNA FLNB

1.51e-03111002IPR017868
DomainP-loop_NTPase

DLG5 RTEL1 SEPTIN9 GBP1 RAB40A RAB10 ERAL1 RAB40AL DLG3 KIF3C DDX39A DDX39B

1.90e-0384810012IPR027417
Domain-

DLG5 RTEL1 SEPTIN9 GBP1 RAB40A RAB10 ERAL1 RAB40AL DLG3 DDX39A DDX39B

2.14e-03746100113.40.50.300
DomainCADHERIN_1

PCDHB5 PCDHB4 CLSTN2 CDH4

3.19e-031131004PS00232
DomainCadherin

PCDHB5 PCDHB4 CLSTN2 CDH4

3.19e-031131004PF00028
DomainCADHERIN_2

PCDHB5 PCDHB4 CLSTN2 CDH4

3.29e-031141004PS50268
Domain-

PCDHB5 PCDHB4 CLSTN2 CDH4

3.29e-0311410042.60.40.60
DomainCA

PCDHB5 PCDHB4 CLSTN2 CDH4

3.40e-031151004SM00112
DomainCadherin-like

PCDHB5 PCDHB4 CLSTN2 CDH4

3.50e-031161004IPR015919
DomainPyr_redox_2

DPYD TXNRD1

4.57e-03191002PF07992
DomainSOCS

RAB40A RAB40AL

5.06e-03201002SM00253
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

FLNA FLNB DLG5 RAPGEF6 ESYT1 POLH LARP1 JMJD1C AHNAK XRN1 AHNAK2

3.04e-102561031133397691
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

SETD1A FLNA FLNB EML4 USP11 ESYT1 SEPTIN9 MCCC1 POLR1G MIDEAS POLR1E ERAL1 AHNAK XRN1 DDX39A NOP2 ATP2B1 BAG6 DDX39B RPL8 AHNAK2

4.08e-1013531032129467282
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

GPHN FLNA FLNB VWF SELENBP1 SEPTIN9 DYRK1A LARP1 ACTR3B SHROOM2 RAB10 DIP2A HECW2 CPEB4 XRN1 DLG3 ATP2B1 DDX39B RPL8 CPSF7

6.72e-0914311032037142655
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

DAB2IP JCAD FLNA FLNB DLG5 ESYT1 SEPTIN9 LARP1 RAB10 AHNAK XRN1 ATP2B1 DDX39B

1.35e-085651031325468996
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

FLNA DLG5 FOXK2 CDC42BPA EML4 ESYT1 SEPTIN9 LARP1 MIDEAS RAB10 IGF2BP1 TSR1 ERAL1 AHNAK CPEB4 NOP2 ALK DDX39B CPSF7

1.94e-0813711031936244648
Pubmed

BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.

SETD1A FLNA FLNB EML4 ESYT1 SEPTIN9 LARP1 IGF2BP1 TSR1 NOP2 BAG6 DDX39B RPL8 CPSF7

2.53e-087111031433022573
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

FLNA FLNB ESYT1 MCCC1 POLR1G MIDEAS JMJD1C RAB10 TSR1 POLR1E AHNAK ATP6V1C2 NOP2 DDX39B RPL8 CPSF7

3.60e-089891031636424410
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

GPHN JCAD DLG5 RAPGEF6 CDC42BPA ESYT1 DYRK1A LARP1 MCCC1 TIAM1 AHNAK XRN1 ATP2B1 GEN1 AHNAK2

3.85e-088611031536931259
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

FLNA FLNB SELENBP1 ESYT1 SEPTIN9 LARP1 CLSTN2 MCCC1 TXNRD1 RAB10 AHNAK DDX39A RPL8 AHNAK2

1.20e-078071031430575818
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

FLNA FLNB VWF SEPTIN9 LARP1 MCCC1 AHNAK DDX39B AHNAK2 CPSF7

1.25e-073601031033111431
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

FLNA CCDC174 EML4 SEPTIN9 POLH LARP1 MCCC1 MIDEAS JMJD1C IGF2BP1 AHNAK NOP2 ALK DDX39B CPSF7

1.45e-079541031536373674
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

FLNB DLG5 CDC42BPA ESYT1 SEPTIN9 LARP1 ATE1 JMJD1C RAB10 AHNAK XRN1 ATP2B1 RPL8

1.84e-077081031339231216
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

GPHN FLNA FLNB FOXK2 USP11 ESYT1 ATE1 IGF2BP1 PTPN9 ERAL1 XRN1 LRP1 NOP2 ATP2B1 BAG6

1.89e-079741031528675297
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

DAB2IP GPHN JCAD FLNA FLNB CDC42BPA SEPTIN9 MCCC1 ACTR3B ATE1 SHROOM2 CPEB4 XRN1 DLG3 DDX39B RPL8

2.44e-0711391031636417873
Pubmed

Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases.

FLNA FLNB EML4 SEPTIN9 LARP1 IGF2BP1 DDX39A NOP2 AHNAK2

2.51e-07295103926209609
Pubmed

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.

FLNA CCDC174 SEPTIN9 MCCC1 JMJD1C IGF2BP1 AHNAK AHNAK2 CPSF7

2.74e-07298103930737378
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

DAB2IP GPHN FLNA FLNB FOXK2 SEPTIN9 LARP1 POLR1G IGF2BP1 NOP2 BAG6

3.13e-075031031116964243
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

FLNA FLNB SEPTIN9 RAB10 IGF2BP1 BBS7 ERAL1 AHNAK SCIN NOP2 ATP2B1 BAG6 DDX39B RPL8 CPSF7

3.57e-0710241031524711643
Pubmed

Analysis of HIV-1 Gag protein interactions via biotin ligase tagging.

FLNA FLNB LARP1 AHNAK XRN1

5.82e-0754103525631074
Pubmed

The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.

FLNA LARP1 MCCC1 IGF2BP1 AHNAK DDX39A NOP2 RPL8 CPSF7

6.42e-07330103932529326
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

FLNA FLNB EML3 TSR1 AHNAK DDX39A DDX39B AHNAK2 CPSF7

6.75e-07332103932786267
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

GPHN FLNA RAPGEF6 ESYT1 SEPTIN9 LARP1 MCCC1 IGF2BP1 AHNAK XRN1 SCIN NOP2 RPL8 AHNAK2

6.92e-079341031433916271
Pubmed

Charting the landscape of tandem BRCT domain-mediated protein interactions.

FLNA FLNB SELENBP1 USP11 DYRK1A LARP1 PTPN9 TSR1 POLR1E ERAL1 NOP2 DDX39B

7.34e-076701031222990118
Pubmed

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

FLNA RTEL1 ESYT1 MIDEAS RAB10 TSR1 AHNAK XRN1 CPSF7

8.22e-07340103924332808
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

FLNA FLNB DLG5 SEPTIN9 LARP1 POLR1G RAB10 IGF2BP1 TSR1 AHNAK DDX39A NOP2 DDX39B RPL8

8.35e-079491031436574265
Pubmed

Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain.

EML4 EML3 ALK

8.75e-077103325740311
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

FLNA FOXK2 CCDC174 SEPTIN9 LARP1 MIDEAS JMJD1C TXNRD1 RAB10 IGF2BP1 DDX39A NOP2 BAG6 MNT CPSF7

9.05e-0711031031534189442
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DAB2IP SETD1A FLNA RAPGEF6 FOXK2 CDC42BPA ESYT1 HECTD4 DYRK1A EML3 PIM3 DIP2A AHNAK AHNAK2 BAHCC1

9.26e-0711051031535748872
Pubmed

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.

FLNA RAPGEF6 DYRK1A LARP1 SHROOM2 EML3 TIAM1 DDX39B

9.76e-07255103815324660
Pubmed

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.

FLNA FLNB LARP1 TXNRD1 IGF2BP1 TSR1 ERAL1 LRP1 SCIN NOP2 ATP2B1 BAG6 DDX39B CPSF7

1.09e-069711031433306668
Pubmed

POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.

POTEB3 POTED POTEC

1.40e-068103312475935
Pubmed

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.

FLNA FLNB GBP1 AHNAK DDX39A ATP2B1 DDX39B AHNAK2

1.42e-06268103833024031
Pubmed

A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.

DLG5 SEPTIN9 DYRK1A MCCC1 AHNAK AHNAK2

1.47e-06118103630979931
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

GPHN FOXN1 FOXK2 USP11 ESYT1 DYRK1A LARP1 JMJD1C ERAL1 LRP1 DDX39A ATP2B1 MNT

1.57e-068571031325609649
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

FLNA EML4 SEPTIN9 LARP1 MCCC1 AHNAK CPEB4 XRN1 NOP2 GEN1 DDX39B AHNAK2

1.64e-067241031236232890
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

SETD1A FLNA ESYT1 LARP1 MCCC1 POLR1G RAB10 IGF2BP1 TSR1 POLR1E AHNAK PKLR DDX39A NOP2 DDX39B RPL8

1.67e-0613181031630463901
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

FLNA FLNB ESYT1 SEPTIN9 LARP1 RAB10 IGF2BP1 AHNAK XRN1 CPSF7

2.38e-064981031036634849
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

FLNA FLNB CDC42BPA LARP1 TIAM1 AHNAK XRN1

2.48e-06202103733005030
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

JCAD FOXK2 USP11 DYRK1A LARP1 JMJD1C TSR1 RPL8 BAHCC1

2.99e-06398103935016035
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

GPHN FOXK2 SEPTIN9 LARP1 IGF2BP1 AHNAK BAG6 DDX39B CPSF7

3.05e-06399103935987950
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

FLNA FLNB EML4 ESYT1 IGF2BP1 ERAL1 NOP2 BAG6 DDX39B RPL8 CPSF7

3.15e-066381031133239621
Pubmed

BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.

FLNB DLG5 SEPTIN9 LARP1 AHNAK XRN1 AHNAK2

3.87e-06216103731519766
Pubmed

Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3.

FLNA FLNB BAG6

4.09e-0611103336579465
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

FLNA FLNB RAPGEF6 POLH MCCC1 JMJD1C AHNAK XRN1 LRP1

4.45e-06418103934709266
Pubmed

STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.

FLNA LARP1 IGF2BP1 TSR1 POLR1E DDX39A NOP2 RPL8

4.78e-06316103831665637
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

FLNA FLNB LARP1 IGF2BP1 ERAL1 CPEB4 XRN1 DDX39A NOP2 DDX39B RPL8 CPSF7

4.98e-068071031222681889
Pubmed

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.

FLNA CDC42BPA ESYT1 SEPTIN9 LARP1 IGF2BP1 TSR1 POLR1E AHNAK KIF3C NOP2 RPL8

5.11e-068091031232129710
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

GPHN FLNA FLNB ESYT1 DYRK1A MCCC1 RAB10 AHNAK CPEB4 LRP1 KIF3C ATP2B1 BAG6 MNT RPL8 CPSF7

5.67e-0614511031630550785
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

EML4 USP11 PCDHB5 DYRK1A LARP1 ACTR3B JMJD1C EML3 RAB10 IGF2BP1 TIAM1 TSR1 POLR1E DLG3 BAG6

5.78e-0612841031517353931
Pubmed

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

FLNA FLNB EML4 ESYT1 DYRK1A TXNRD1 ALK RPL8

6.14e-06327103815592455
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

FOXK2 RTEL1 POLH FREM1 HMCN1 PKLR

6.36e-06152103634299191
Pubmed

Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.

FLNA FLNB DYRK1A GBP1 TXNRD1 AHNAK

6.36e-06152103616009940
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

SETD1A USP11 ESYT1 HECTD4 DYRK1A LARP1 NOP2 DDX39B RPL8

6.72e-06440103934244565
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

FLNA FLNB FOXK2 USP11 SEPTIN9 LARP1 RAB10 IGF2BP1 TSR1 AHNAK BAG6 DDX39B RPL8 CPSF7

7.61e-0611491031435446349
Pubmed

Cell cycle-dependent palmitoylation of protocadherin 7 by ZDHHC5 promotes successful cytokinesis.

FLNA MCCC1 AHNAK DDX39A DDX39B RPL8

8.24e-06159103636762613
Pubmed

Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.

FLNA FLNB ESYT1 SEPTIN9 RAB10 IGF2BP1 AHNAK BAG6 DDX39B RPL8 CPSF7

8.31e-067071031119738201
Pubmed

In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype.

ACTR3B RAB10 AHNAK KIF3C SCIN DDX39B

8.54e-06160103623375831
Pubmed

Coupling an EML4-ALK-centric interactome with RNA interference identifies sensitizers to ALK inhibitors.

EML4 ALK

8.69e-062103227811184
Pubmed

Exon scanning by reverse transcriptase-polymerase chain reaction for detection of known and novel EML4-ALK fusion variants in non-small cell lung cancer.

EML4 ALK

8.69e-062103221356191
Pubmed

Nuclear localization of poly(A)+ mRNA following siRNA reduction of expression of the mammalian RNA helicases UAP56 and URH49.

DDX39A DDX39B

8.69e-062103216949217
Pubmed

Clinicopathological and Prognostic Significance of the EML4-ALK Translocation and IGFR1, TTF1, Napsin A Expression in Patients with Lung Adenocarcinoma.

EML4 ALK

8.69e-062103232876329
Pubmed

Malignant pleural mesothelioma with an EML4-ALK fusion: Expect the unexpected!

EML4 ALK

8.69e-062103235074700
Pubmed

A rare case of an EML4-ALK-rearranged lung adenocarcinoma missed by in situ-hybridization but detected by RT-PCR.

EML4 ALK

8.69e-062103225028527
Pubmed

EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer.

EML4 ALK

8.69e-062103218594010
Pubmed

EML4-ALK induces epithelial-mesenchymal transition consistent with cancer stem cell properties in H1299 non-small cell lung cancer cells.

EML4 ALK

8.69e-062103225735977
Pubmed

Terminal regions of UAP56 and URH49 are required for their distinct complex formation functioning to an essential role in mRNA processing and export.

DDX39A DDX39B

8.69e-062103238377942
Pubmed

Identification of risk genes for autism spectrum disorder through copy number variation analysis in Austrian families.

GPHN DIP2A

8.69e-062103224643514
Pubmed

EML4-ALK translocation predicts better outcome in lung adenocarcinoma patients with wild-type EGFR.

EML4 ALK

8.69e-062103222124476
Pubmed

Second Primary Lung Adenocarcinoma Harboring EML4-ALK After Surgically Resected EGFR Positive Lung Adenocarcinoma.

EML4 ALK

8.69e-062103226704814
Pubmed

EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues.

EML4 ALK

8.69e-062103219147828
Pubmed

Targeting stemness is an effective strategy to control EML4-ALK+ non-small cell lung cancer cells.

EML4 ALK

8.69e-062103226517679
Pubmed

Preselection based on clinical characteristics in German non-small-cell lung cancer patients screened for EML4-ALK translocation.

EML4 ALK

8.69e-062103224346098
Pubmed

Binding of the human cytomegalovirus (HCMV) tegument protein UL69 to UAP56/URH49 is not required for efficient replication of HCMV.

DDX39A DDX39B

8.69e-062103220610707
Pubmed

Phase-separated foci of EML4-ALK facilitate signalling and depend upon an active kinase conformation.

EML4 ALK

8.69e-062103234661367
Pubmed

Circular RNA F-circEA-2a derived from EML4-ALK fusion gene promotes cell migration and invasion in non-small cell lung cancer.

EML4 ALK

8.69e-062103230236141
Pubmed

A novel mechanism of EML4-ALK rearrangement mediated by chromothripsis in a patient-derived cell line.

EML4 ALK

8.69e-062103225144242
Pubmed

Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndrome.

FLNA FLNB

8.69e-062103217635842
Pubmed

Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts.

EML4 ALK

8.69e-062103218927303
Pubmed

EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas.

EML4 ALK

8.69e-062103218242762
Pubmed

Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes.

DDX39A DDX39B

8.69e-062103238225262
Pubmed

Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer.

EML4 ALK

8.69e-062103218593892
Pubmed

Expanded Circulating Tumor Cells from a Patient with ALK-Positive Lung Cancer Present with EML4-ALK Rearrangement Along with Resistance Mutation and Enable Drug Sensitivity Testing: A Case Study.

EML4 ALK

8.69e-062103227507192
Pubmed

PAF49: An RNA Polymerase I subunit essential for rDNA transcription and stabilization of PAF53.

POLR1G POLR1E

8.69e-062103237356716
Pubmed

Structural and functional aspects of filamins.

FLNA FLNB

8.69e-062103211336782
Pubmed

The variants at FLNA and FLNB contribute to the susceptibility of hypertension and stroke with differentially expressed mRNA.

FLNA FLNB

8.69e-062103233649519
Pubmed

EML4-ALK fusion transcript is not found in gastrointestinal and breast cancers.

EML4 ALK

8.69e-062103218414414
Pubmed

The impact of the ALK fusion variant on clinical outcomes in EML4-ALK patients with NSCLC: a systematic review and meta-analysis.

EML4 ALK

8.69e-062103234783600
Pubmed

The prevalence of ALK rearrangement in pulmonary adenocarcinomas in an unselected Caucasian population from a defined catchment area: impact of smoking.

EML4 ALK

8.69e-062103227943404
Pubmed

Characterization of the interactions of mammalian RNA polymerase I associated proteins PAF53 and PAF49.

POLR1G POLR1E

8.69e-062103222849406
Pubmed

Investigation on the prognostic impact of concurrent genomic alterations in crizotinib-treated EML4-ALK-rearranged advanced non-small cell lung cancer patients.

EML4 ALK

8.69e-062103232563740
Pubmed

Effective enrichment strategy for EML4-ALK fusion gene screening in patients with non-small cell lung cancer.

EML4 ALK

8.69e-062103224388371
Pubmed

Circular RNA F-circEA produced from EML4-ALK fusion gene as a novel liquid biopsy biomarker for non-small cell lung cancer.

EML4 ALK

8.69e-062103229628502
Pubmed

The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells.

AHNAK AHNAK2

8.69e-062103215007166
Pubmed

New insights into anaplastic lymphoma kinase-positive nonsmall cell lung cancer.

EML4 ALK

8.69e-062103229199691
Pubmed

Clinicopathological features of younger (aged ≤ 50 years) lung adenocarcinoma patients harboring the EML4-ALK fusion gene.

EML4 ALK

8.69e-062103229517858
Pubmed

Malignant pleural effusion cell blocks are substitutes for tissue in EML4-ALK rearrangement detection in patients with advanced non-small-cell lung cancer.

EML4 ALK

8.69e-062103227060609
Pubmed

AHNAK1 and AHNAK2 are costameric proteins: AHNAK1 affects transverse skeletal muscle fiber stiffness.

AHNAK AHNAK2

8.69e-062103220833135
Pubmed

MEK inhibitor trametinib does not prevent the growth of anaplastic lymphoma kinase (ALK)-addicted neuroblastomas.

FOXN1 ALK

8.69e-062103229184034
Pubmed

Whole-genome sequencing of an aggressive BRAF wild-type papillary thyroid cancer identified EML4-ALK translocation as a therapeutic target.

EML4 ALK

8.69e-062103224633422
Pubmed

The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression.

DDX39A DDX39B

8.69e-062103220573985
InteractionHDAC1 interactions

FLNA FLNB RAPGEF6 FOXK2 CDC42BPA EML4 USP11 POLH MCCC1 POLR1G MIDEAS JMJD1C PHF1 TSR1 POLR1E AHNAK XRN1 KDM4A MNT BAHCC1

4.30e-07110810020int:HDAC1
InteractionPOTED interactions

POTEB3 POTED POTEC

4.72e-0741003int:POTED
InteractionPHLPP1 interactions

FLNA FLNB DLG5 RAPGEF6 ESYT1 POLH LARP1 JMJD1C AHNAK XRN1 AHNAK2

8.13e-0733310011int:PHLPP1
InteractionTOP3B interactions

DAB2IP SETD1A FLNA RAPGEF6 FOXK2 CDC42BPA RTEL1 ESYT1 HECTD4 DYRK1A EML3 PIM3 DIP2A IGF2BP1 AHNAK CPEB4 XRN1 KDM4A NOP2 DDX39B AHNAK2 BAHCC1

2.42e-06147010022int:TOP3B
InteractionSIRT6 interactions

SETD1A FLNA FLNB FOXK2 USP11 ESYT1 HECTD4 DYRK1A LARP1 NOP2 BAG6 DDX39B RPL8

1.37e-0562810013int:SIRT6
InteractionKIF20A interactions

FLNA FLNB POLH APC2 HECTD4 DYRK1A LARP1 POLR1G RAB10 IGF2BP1 AHNAK XRN1 SCIN NOP2 DDX39B RPL8 AHNAK2

1.54e-05105210017int:KIF20A
InteractionMEX3A interactions

FLNA FLNB LARP1 IGF2BP1 AHNAK CPEB4 SCIN NOP2 DDX39B AHNAK2

2.12e-0538410010int:MEX3A
InteractionPOTEC interactions

POTEB3 POTED POTEC

3.27e-05131003int:POTEC
InteractionSUMO2 interactions

FLNA FLNB SELENBP1 USP11 EML3 TSR1 AHNAK DDX39A NOP2 DDX39B AHNAK2 CPSF7

3.62e-0559110012int:SUMO2
InteractionKCTD13 interactions

GPHN FLNA FLNB VWF SEPTIN9 DYRK1A LARP1 ACTR3B SHROOM2 RAB10 DIP2A HECW2 CPEB4 XRN1 DLG3 ATP2B1 DDX39B RPL8 CPSF7

4.86e-05139410019int:KCTD13
InteractionLIMA1 interactions

FLNA FLNB USP11 SEPTIN9 LARP1 PHF1 PIM3 TIAM1 AHNAK DDX39B

5.40e-0542910010int:LIMA1
InteractionTARDBP interactions

FLNB DYRK1A LARP1 TSR1 AHNAK XRN1 SCIN NOP2 BAG6 DDX39B RPL8

5.42e-0552010011int:TARDBP
InteractionLYN interactions

DAB2IP DLG5 CDC42BPA ESYT1 SEPTIN9 LCP2 PIM3 TIAM1 TSR1 PLEKHH2 ATP2B1 DDX39B AHNAK2

5.64e-0572010013int:LYN
InteractionSINHCAF interactions

FOXK2 SELENBP1 USP11 IGF2BP1 HECW2 BAHCC1

5.75e-051351006int:SINHCAF
InteractionFZR1 interactions

FLNA FLNB DYRK1A LARP1 TXNRD1 IGF2BP1 TSR1 ERAL1 HECW2 LRP1 SCIN NOP2 ATP2B1 BAG6 DDX39B RPL8 CPSF7

6.01e-05117210017int:FZR1
InteractionLRRC31 interactions

FLNA FLNB CDC42BPA LARP1 TIAM1 AHNAK XRN1

7.32e-052051007int:LRRC31
InteractionNDN interactions

FLNA LARP1 MCCC1 IGF2BP1 AHNAK DDX39A NOP2 CDH4 RPL8 CPSF7

8.49e-0545310010int:NDN
InteractionHDAC2 interactions

FLNA FOXK2 CCDC174 EML4 USP11 SEPTIN9 MCCC1 MIDEAS JMJD1C PHF1 IGF2BP1 AHNAK AHNAK2 CPSF7

9.26e-0586510014int:HDAC2
InteractionYAP1 interactions

GPHN JCAD SETD1A FLNA FLNB RAPGEF6 APC2 LARP1 MIDEAS JMJD1C TSR1 HECW2 AHNAK PKLR DDX39B CPSF7

9.35e-05109510016int:YAP1
InteractionKCNA3 interactions

FLNB DLG5 CDC42BPA ESYT1 SEPTIN9 LARP1 ATE1 JMJD1C RAB10 AHNAK XRN1 DDX39A ATP2B1 RPL8

9.96e-0587110014int:KCNA3
InteractionAATF interactions

RTEL1 LARP1 POLR1G IGF2BP1 POLR1E NOP2 DDX39B RPL8 CPSF7

1.06e-043761009int:AATF
InteractionCDH1 interactions

DAB2IP JCAD FLNA FLNB DLG5 ESYT1 SEPTIN9 LARP1 RAB10 AHNAK XRN1 ATP2B1 DDX39B

1.08e-0476810013int:CDH1
InteractionSMC5 interactions

FLNA CCDC174 EML4 SEPTIN9 POLH LARP1 MCCC1 MIDEAS JMJD1C IGF2BP1 AHNAK NOP2 ALK DDX39B CPSF7

1.19e-04100010015int:SMC5
InteractionYWHAG interactions

DAB2IP GPHN JCAD FLNA DLG5 RAPGEF6 CDC42BPA ESYT1 HECTD4 DYRK1A LARP1 SHROOM2 EML3 TIAM1 GEN1 DDX39B AHNAK2

1.30e-04124810017int:YWHAG
InteractionOBSL1 interactions

FLNA FLNB SEPTIN9 DYRK1A POLR1G MIDEAS IGF2BP1 POLR1E AHNAK SCIN NOP2 DDX39B RPL8 CPSF7

1.44e-0490210014int:OBSL1
InteractionCDK9 interactions

FLNA FLNB CDC42BPA EML4 SEPTIN9 LARP1 IGF2BP1 DDX39A NOP2 ALK AHNAK2 CPSF7

1.47e-0468510012int:CDK9
InteractionDXO interactions

SELENBP1 XRN1 DDX39A

1.48e-04211003int:DXO
InteractionJSRP1 interactions

AHNAK DDX39A AHNAK2

1.48e-04211003int:JSRP1
InteractionABCA1 interactions

DLG5 RAPGEF6 TIAM1 DLG3

1.49e-04541004int:ABCA1
InteractionC11orf52 interactions

DAB2IP DLG5 CDC42BPA ESYT1 DIP2A TIAM1 DLG3 ATP2B1

1.60e-043111008int:C11orf52
InteractionISG15 interactions

FLNA FLNB DYRK1A GBP1 TXNRD1 AHNAK DDX39A ATP2B1 DDX39B AHNAK2

1.72e-0449410010int:ISG15
InteractionRAPGEF2 interactions

DAB2IP RAPGEF6 USP11 DYRK1A HMCN1

1.77e-041051005int:RAPGEF2
InteractionFBXL4 interactions

FLNA SELENBP1 TXNRD1 BBS7 KDM4A

1.85e-041061005int:FBXL4
InteractionPPP1R12A interactions

FLNA EML4 USP11 SEPTIN9 DYRK1A TSR1 AHNAK DDX39B

2.03e-043221008int:PPP1R12A
InteractionOTUD1 interactions

FLNA FLNB USP11 DDX39A NOP2 BAG6

2.04e-041701006int:OTUD1
InteractionAGR2 interactions

FLNA FLNB SELENBP1 ESYT1 SEPTIN9 LARP1 CLSTN2 MCCC1 TXNRD1 RAB10 AHNAK DDX39A RPL8 AHNAK2

2.06e-0493410014int:AGR2
InteractionICE1 interactions

SEPTIN9 DYRK1A POLR1G POLR1E

2.11e-04591004int:ICE1
InteractionCHD4 interactions

SETD1A FOXK2 EML4 USP11 LARP1 PHF1 IGF2BP1 TSR1 AHNAK XRN1 DDX39A NOP2 DDX39B RPL8

2.16e-0493810014int:CHD4
InteractionWDHD1 interactions

SELENBP1 EML4 DYRK1A POLR1G PHF1 BAG6

2.54e-041771006int:WDHD1
InteractionFN1 interactions

FLNA FLNB ESYT1 SEPTIN9 DYRK1A CFB RAB10 IGF2BP1 AHNAK BAG6 DDX39B RPL8 CPSF7

2.85e-0484810013int:FN1
InteractionPHF21A interactions

FLNA FLNB RAPGEF6 POLH MCCC1 JMJD1C AHNAK XRN1

3.10e-043431008int:PHF21A
InteractionGP1BA interactions

FLNA FLNB VWF

3.18e-04271003int:GP1BA
InteractionNAA40 interactions

GPHN FLNA RAPGEF6 ESYT1 SEPTIN9 LARP1 MCCC1 IGF2BP1 AHNAK XRN1 SCIN NOP2 RPL8 AHNAK2

3.30e-0497810014int:NAA40
InteractionWDR5 interactions

SETD1A FLNA FLNB EML4 ESYT1 SEPTIN9 LARP1 IGF2BP1 TSR1 POLR1E NOP2 BAG6 DDX39B RPL8 CPSF7

3.37e-04110110015int:WDR5
InteractionDYNLL2 interactions

GPHN JCAD DLG5 EML4 DYRK1A EML3 PLEKHH2

3.39e-042631007int:DYNLL2
InteractionYWHAH interactions

DAB2IP JCAD DLG5 RAPGEF6 CDC42BPA ESYT1 HECTD4 DYRK1A LARP1 EML3 TIAM1 AHNAK XRN1 GEN1 AHNAK2

3.40e-04110210015int:YWHAH
InteractionGBF1 interactions

FLNB DLG5 SEPTIN9 DYRK1A LARP1 AHNAK XRN1 ATP2B1 AHNAK2

3.53e-044421009int:GBF1
InteractionSEPTIN9 interactions

FLNB CDC42BPA SEPTIN9 DYRK1A ACTR3B RAB10 TNXB

3.55e-042651007int:SEPTIN9
InteractionFERMT2 interactions

GPHN FLNA SEPTIN9 DYRK1A GBP1 IGF2BP1

3.61e-041891006int:FERMT2
Cytoband6p21.3

CFB PHF1 TNXB BAG6 DDX39B

2.61e-0425010356p21.3
Cytoband2p23

KIF3C ALK

6.63e-041710322p23
Cytoband20q13.3

RTEL1 CDH4

9.22e-0420103220q13.3
CytobandEnsembl 112 genes in cytogenetic band chr6p21

POLH CFB PHF1 TNXB BAG6 DDX39B

9.80e-045031036chr6p21
GeneFamilyPDZ domain containing

DLG5 RAPGEF6 SHROOM2 TIAM1 AHNAK DLG3 AHNAK2

2.19e-061527171220
GeneFamilyAnkyrin repeat domain containing|POTE ankyrin domain containing

POTED POTEC

1.15e-0313712685
CoexpressionHALLMARK_MITOTIC_SPINDLE

FLNA FLNB RAPGEF6 CDC42BPA SEPTIN9 SHROOM2 TIAM1 KIF3C

9.82e-071991008M5893
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GPHN DLG5 FREM1 TIAM1 ATP6V1C2 CLNK SCIN

1.81e-07178102751d2188406f04329311b2efd1108fc36617a860e
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JCAD VWF SHROOM2 PIM3 TIAM1 CFAP53

1.87e-06160102633050dc646762dc7e9dcc4a12c618e1ba1ce5a4d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DLG5 FREM1 TIAM1 ATP6V1C2 CLNK SCIN

3.25e-0617610266c7edf1cb38644500bce6c5a1dd90bbe17415cdb
ToppCellNS-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

VWF SELENBP1 PPP1R1C ATP6V1C2 SCIN ALK

3.58e-06179102665a96bee7bc28f5bfc20f0fd92bcc0ab2eb5e06c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GPHN FREM1 TIAM1 ATP6V1C2 CLNK SCIN

3.69e-061801026cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FREM1 TIAM1 LRP1 PLEKHH2 TNXB ACSS3

3.69e-06180102608ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCellCOVID-19-kidney-CD-IC-B|COVID-19 / Disease (COVID-19 only), tissue and cell type

DLG5 FREM1 TIAM1 ATP6V1C2 CLNK SCIN

3.94e-061821026ee6a8c356bbbdae55e4ea858337e079491f9f4aa
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-hematologic|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CDC42BPA SELENBP1 FREM1 ERMAP PKLR GALNT5

4.06e-0618310261db466cf757813322db1cdcc0bf1d91c062fd9de
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JCAD MIDEAS JMJD1C TXNRD1 ITPKC ATP2B1

4.33e-061851026eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCellCOVID-19-kidney-CD-IC-B|kidney / Disease (COVID-19 only), tissue and cell type

DLG5 FREM1 TIAM1 ATP6V1C2 CLNK SCIN

4.60e-061871026ce05b89860573fe0356102e2998d1ef6d1968034
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JCAD FLNA RAB10 HMCN1 AHNAK ATP2B1

5.04e-061901026d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D175|Adult / Lineage, Cell type, age group and donor

EML4 SEPTIN9 LCP2 RAB10 TIAM1 LRP1

5.35e-061921026733491e932350e3c216a626cc49c3cd3fe970a82
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SELENBP1 HECTD4 CPEB4 ERMAP GALNT5 TNXB

5.51e-061931026305e15ee467826ee08b2617c69f250ad39c11b19
ToppCellwk_08-11-Hematologic-Meg-ery-Definitive_erythroblast|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SELENBP1 HECTD4 LARP1 CPEB4 ERMAP GALNT5

5.51e-061931026be75abfdf5301cf33df8ee9ed92504d44fdf19a6
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-erythrocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SELENBP1 HECTD4 CPEB4 ERMAP GALNT5 TNXB

5.51e-061931026dd376664906caccc9c2065f8e7a364509e18a5cc
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

JCAD VWF LCP2 HMCN1 HECW2 TNXB

6.20e-061971026c10dd1aaec01fb662eac83dfde90e3e426665d65
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DPYD FREM1 TIAM1 LRP1 PLEKHH2 CDH4

6.20e-06197102631a1852911bda38543916585fda34255fd62a134
ToppCellCOVID-19_Mild|World / Disease group, lineage and cell class

EML4 GBP1 JMJD1C PIM3 XRN1 ATP2B1

6.20e-0619710265c33454b10023decd2f5ccda9229b6512659711e
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

JCAD VWF LCP2 HMCN1 HECW2 TNXB

6.20e-0619710262844dbcd0a673ed81c99920aa45858651a00736d
ToppCellCOVID-19_Mild|World / Disease condition and Cell class

FLNA GBP1 LCP2 PIM3 AHNAK LRP1

6.38e-06198102661ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)

EML4 GBP1 JMJD1C PIM3 XRN1 ATP2B1

6.38e-06198102644417089b62056269cac38d3134ff209c05b7007
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

EML4 GBP1 JMJD1C PIM3 XRN1 ATP2B1

6.38e-06198102628ef3fc4c17dcb765537b75917f7db78baa522db
ToppCellCOVID-19_Severe-Classical_Monocyte-cMono_3|COVID-19_Severe / Disease condition and Cell class

FLNA DPYD AHNAK LRP1 ATP2B1 RPL8

6.57e-061991026ffb2ef9b7006cbed0f43637af040719b9776cbd5
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DLG5 VWF ATP6V1C2 CLNK AHNAK2

1.54e-0513610257cd22169fb71c6caf9feb203ad98be8480a54fba
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RAB40A FREM1 ATP6V1C2 CLNK SCIN

1.60e-05137102581cdb216e6c81acf9c2072f9d39e1a42612e1258
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DLG5 TIAM1 ATP6V1C2 CLNK AHNAK2

2.17e-051461025ec1f793409d1a81c0f9323eb3c82ffe01dae0e44
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEPTIN9 FREM1 ATP6V1C2 CLNK SCIN

2.47e-05150102587968ce885a4959616f0321f58517fe8029ba1b1
ToppCellfacs-Marrow-T-cells-24m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA CFB AHNAK LRP1 ATP2B1

2.64e-051521025d279592c501fca9cb474ad916fea32282e6969cb
ToppCellfacs-Marrow-T-cells-24m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA CFB AHNAK LRP1 ATP2B1

2.64e-0515210253b59143b2b4ee24eb6378f87ff568124193256e9
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Nts|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PKLR PPP1R1C GALNT5 CFAP53

2.97e-05771024dbbefd2dfa4c345172cb5a995952e3682fbadf92
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DLG5 GBP1 MIDEAS BBS7 XRN1

3.68e-051631025d005115aa1e1458b51de7eb719794617a4168608
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

EML4 GBP1 XRN1 NOP2 CDH4

4.13e-051671025a54b8e03987a7b067173121902e1811a3d003692
ToppCell3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Progenitor|lymph-node_spleen / Manually curated celltypes from each tissue

GRIK5 SLC8A3 PPP1R1C CLNK BAHCC1

4.13e-051671025cb396f3edb9e8fdc316091e8e193dbba50e0be0c
ToppCellNS-critical-d_16-33-Epithelial-Ionocyte|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PPP1R1C ATP6V1C2 CLNK SCIN ALK

4.25e-0516810256a233045638cb83dab64789b996b7598c325001e
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs|Fibroblasts / Location, Cell class and cell subclass

MCCC1 CFB ITPKC PLEKHH2 TNXB

4.37e-05169102584b898a9fd8ced67c6a501d5cef6416f519902c4
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF SHROOM2 HMCN1 KIF3C SCIN

5.30e-0517610257292e014b8f697f0c2e9f47c48333de95cb44a69
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF SHROOM2 HMCN1 KIF3C SCIN

5.30e-05176102588ca2f83d8301633232735f39b0683efe49d0b86
ToppCellPBMC-Mild-cDC_11|Mild / Compartment, Disease Groups and Clusters

FLNB CLSTN2 DLG3 ATP6V1C2 CLNK

5.45e-051771025974305e4c0eff90134c4e58cf11b955d1eee0501
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FREM1 TIAM1 LRP1 PLEKHH2 TNXB

5.90e-0518010259b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

RAPGEF6 EML4 JMJD1C AHNAK DDX39B

6.06e-051811025f2315414e714ac86211546a935660c4be6e85f1b
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-ependymal_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDR93 PKLR SCIN CFAP53 ACSS3

6.22e-051821025587636c0f127231de21acd8aa632b74ff22ca8c2
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Ependyma|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDR93 PKLR SCIN CFAP53 ACSS3

6.22e-051821025adfadd7893e74b3002f13f00875e3667d3493e0c
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DAB2IP VWF GRIK5 ACTR3B WDR93

6.38e-0518310256f8f997ffc9eaebca2683de125b6069d07c07d26
ToppCellcritical-Epithelial-Ionocyte|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ACTR3B PPP1R1C ATP6V1C2 CLNK ALK

6.55e-05184102558d36577eff814d46d72f031f3533d71549e3d6e
ToppCellFetal_29-31_weeks-Immune-enucleated_erythrocyte-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SELENBP1 HECTD4 CPEB4 ERMAP GALNT5

6.72e-051851025c4bf3ac684c1a8876b51f7af4d3a62dc47e961ee
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EML4 JMJD1C AHNAK XRN1 ATP2B1

6.72e-0518510257adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM1 SLC8A3 HMCN1 LRP1 TNXB

6.72e-051851025785c55d39909fac74415f24427979691e7e694e6
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM1 SLC8A3 HMCN1 LRP1 TNXB

6.72e-05185102597a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM1 SLC8A3 HMCN1 LRP1 TNXB

6.89e-05186102594d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KLHL1 JMJD1C AHNAK CPEB4 LRP1

6.89e-05186102523b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellMyeloid-B_(Activated_Macrophage)|World / shred on cell class and cell subclass (v4)

SEPTIN9 LCP2 CFB LRP1 AHNAK2

6.89e-05186102533d731a7883d75e4e7db83b641cdb1e9a39938bf
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAB2IP JCAD VWF HMCN1 AHNAK

6.89e-0518610250ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellfacs-Heart-LA-24m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELENBP1 CFB LRP1 SCIN TNXB

6.89e-051861025ed0a91f47e77fe21d4c7678d0f2a7c5f97d63dda
ToppCellsevere_influenza-RBC|World / disease group, cell group and cell class (v2)

SELENBP1 CPEB4 ERMAP PKLR TNXB

7.07e-051871025f846750575f318503d21ade30f5bfd2e1d4c84af
ToppCellfacs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELENBP1 CFB LRP1 SCIN TNXB

7.07e-051871025f3ef3f5a761f8306edc39bf16e76e44aae6fa7f6
ToppCellfacs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELENBP1 CFB LRP1 SCIN TNXB

7.07e-0518710251669df899b1759c338ffce196fe009840123cfcd
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FREM1 CPEB4 ATP6V1C2 CLNK SCIN

7.25e-051881025e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCellEndothelial-A-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

JCAD VWF TEX13D HECW2 TNXB

7.25e-0518810250824d567356d360fd8e78e840c30529c139f98a1
ToppCellControl-B_intermediate-6|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

FLNA FLNB AHNAK CPEB4 GEN1

7.43e-05189102511cb9a16f1de8f60af2073ed7ea6d4f41c02f299
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

GBP1 FREM1 HMCN1 TIAM1 PLEKHH2

7.43e-051891025203c80030df08ae112f9ae4043709f455d87ce89
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYD CLSTN2 SLC8A3 BBS7 SCIN

7.43e-0518910254dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYD CLSTN2 SLC8A3 BBS7 SCIN

7.43e-0518910250d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SEPTIN9 FREM1 ATP6V1C2 CLNK SCIN

7.43e-051891025532aaf02b364c5c4f58a2021c7c21d86df3875c9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SEPTIN9 FREM1 ATP6V1C2 CLNK SCIN

7.62e-051901025b3bccf4dd95e986db3cee324a6737f5fcc22e8e5
ToppCellMyeloid-Myeloid-B_(Activated_Macrophage)|Myeloid / shred on cell class and cell subclass (v4)

FLNA SEPTIN9 CFB LRP1 AHNAK2

7.81e-0519110257bf125249af1e8bb138ed4d999fdd74b03ab2447
ToppCellfacs-Heart-LA-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JCAD VWF SHROOM2 FREM1 HMCN1

8.00e-05192102514a816ef116aa992f86edab411f043cf7d07fe04
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEPTIN9 FREM1 ATP6V1C2 CLNK SCIN

8.00e-051921025f7e7491426bbd6ed29a465b58bf67acb93dbb90a
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

RAPGEF6 EML4 JMJD1C AHNAK DDX39B

8.00e-05192102547646d7e4990be85072987f92bf18d52f8da752e
ToppCellfacs-Heart-LA-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JCAD VWF SHROOM2 FREM1 HMCN1

8.00e-051921025847822514d747a21d5eb40e04ba9a023fd32bd65
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DPYD HMCN1 HECW2 PLEKHH2 CDH4

8.20e-0519310259f69edc97b868d23998abc98928a2e89a885ef8a
ToppCellLPS-antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

JCAD FLNB VWF HMCN1 HECW2

8.20e-0519310256e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLNB SEPTIN9 RAB10 ITPKC TIAM1

8.20e-051931025a5695ce2e24a62026ae28f3dea07ca4a435206b8
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-naive_regulatory_T_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GPHN SEPTIN9 LCP2 TIAM1 RPL8

8.20e-05193102528138c35ea82c6b2163f0cae045ca55859347c73
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB ESYT1 AHNAK LRP1 ATP2B1

8.20e-0519310255a201ee6f132357c9aacfbad3ae56ed9854c25fd
ToppCellNS-critical-d_07-13-Epithelial-Secretory|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FLNB CDC42BPA SELENBP1 CFB GALNT5

8.40e-0519410252172d951896265243d14996eacce5aab5e14e26e
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FREM1 SLC8A3 TIAM1 PLEKHH2 CDH4

8.40e-051941025b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCelldroplet-Trachea-nan-3m-Mesenchymal-mesenchymal_progenitor_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JCAD CFB LRP1 CDH4 TNXB

8.40e-0519410253d25d6ebec8d1b6001f602257cd15b3ba04cf0c1
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

JCAD CFB LRP1 CDH4 TNXB

8.40e-051941025ff19fb5bc7feae3e774ef4ab720beb9dec219f45
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DPYD FREM1 LRP1 PLEKHH2 CDH4

8.61e-0519510251cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FLNA EML4 ESYT1 SEPTIN9 AHNAK

8.61e-051951025e06ff785c5542c86c335d956799e03f7ae8345a4
ToppCellControl-Classical_Monocyte-cMono_2|Control / Disease condition and Cell class

FLNA DPYD JMJD1C AHNAK LRP1

8.61e-0519510250fea64ee3eedf3929abb0dd9c5f5fc72f181eed9
ToppCellASK452|World / Donor, Lineage and Cell class of Lung cells from Dropseq

LCP2 JMJD1C ITPKC PLEKHH2 ATP2B1

8.61e-0519510257efd9d3a3f5e7dfe9698a4143ce4a0f9bf3a862c
ToppCellNS-moderate-d_16-33-Epithelial-Secretory|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FLNB CDC42BPA CFB GALNT5 SCIN

8.82e-05196102570384c1da9baed843f414cfd1403ddd586a2db07
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FLNA GBP1 LCP2 JMJD1C ATP2B1

8.82e-051961025fe8d3f45a64323947c36b127355d5940eb56c0ca
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DPYD FREM1 TIAM1 LRP1 PLEKHH2

8.82e-0519610251450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FLNA GBP1 LCP2 JMJD1C ATP2B1

8.82e-051961025526d037bb12d81f1c235c60ddc787fbad0bbad77
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

JCAD VWF HMCN1 HECW2 TNXB

8.82e-051961025e224338490691d92c1f70b57112fabdcc92b06a9
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FOXN1 FLNB AHNAK GALNT5 AHNAK2

9.03e-051971025fb272c9c60ee3d980e528044dc567b4925a23da6
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FOXN1 FLNB AHNAK GALNT5 AHNAK2

9.03e-05197102561c0d78b29dc4ad8a84172cbfcdab03f31351d0e
ToppCellcontrol-Myeloid-Non-resident_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

JMJD1C RAB10 TIAM1 LRP1 ATP2B1

9.03e-051971025df2fe36cb96e2565a9d21c24cb4e451e8befd4be
ToppCellnormal_Lung-T/NK_cells-CD4+_Th|T/NK_cells / Location, Cell class and cell subclass

EML4 PIM3 AHNAK ATP2B1 RPL8

9.03e-05197102580b3902ceea242148a1f1707c633f66afedf5183
ToppCelltumor_Lung-T/NK_cells-CD4+_Th|T/NK_cells / Location, Cell class and cell subclass

EML4 JMJD1C AHNAK ATP2B1 RPL8

9.03e-0519710250379d67beeba5864b5ffe5d282643204a112754f
ToppCellASK452-Epithelial-Transformed_epithelium|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

SELENBP1 TXNRD1 ITPKC PLEKHH2 RPL8

9.03e-051971025b22a79a5922c865a360e2afc5506a08a512fa76a
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FLNA GBP1 LCP2 JMJD1C ATP2B1

9.03e-0519710253cd1c816bc7a57278b2ef615b69545356ab8f522
ToppCellAdult-Immune|Adult / Lineage, Cell type, age group and donor

EML4 LCP2 TIAM1 LRP1 ATP2B1

9.25e-0519810259bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCellsevere-HLA-DR+_CD83+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DPYD JMJD1C CPEB4 LRP1 MNT

9.25e-051981025d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sncg-Sncg_Gpr50|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SELENBP1 FREM1 PPP1R1C CLNK

9.27e-051031024d8965b338b90ddc0686ea0d94e9a330128566c39
ToppCellBAL-Mild-cDC_1|Mild / Compartment, Disease Groups and Clusters

FLNA GBP1 LCP2 XRN1 SCIN

9.47e-051991025c55181bdec8952b54198f0d4c9c5c84265b16572
ToppCellBronchus_Control_(B.)-Epithelial-TX-Transitional_AT2|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

ACTR3B PPP1R1C ATP6V1C2 CLNK SCIN

9.47e-051991025cd581d7330b471431ef427f8a4f5be553f70e068
ToppCellCOVID-19_Severe-Classical_Monocyte|COVID-19_Severe / Disease condition and Cell class

FLNA DPYD AHNAK LRP1 RPL8

9.47e-051991025ea1e2ccde3930fab6d04a9bf130837455c742474
DrugHydrastine hydrochloride [5936-28-7]; Down 200; 9.6uM; PC3; HT_HG-U133A

RTEL1 SEPTIN9 GBP1 ITPKC PTPN9 URM1 DLG3 BAHCC1

2.38e-061979987309_DN
Diseasereticulocyte measurement

GPHN FLNA FLNB FOXK2 VWF SEPTIN9 HECTD4 LARP1 MIDEAS JMJD1C ERAL1 AHNAK CPEB4 PKLR DDX39A ATP2B1 DDX39B

4.05e-0810539517EFO_0010700
Diseasereticulocyte count

FLNB FOXK2 VWF SEPTIN9 HECTD4 LARP1 MIDEAS JMJD1C ERAL1 AHNAK CPEB4 PKLR DDX39A ATP2B1 DDX39B

1.22e-0610459515EFO_0007986
Diseasemyofibrillar myopathy 5 (implicated_via_orthology)

FLNA FLNB

3.07e-053952DOID:0080096 (implicated_via_orthology)
Diseasedistal muscular dystrophy 4 (implicated_via_orthology)

FLNA FLNB

3.07e-053952DOID:0111190 (implicated_via_orthology)
Diseasevon Willebrand factor measurement, coronary artery disease

DAB2IP JCAD VWF HECTD4 ATP2B1

4.08e-05118955EFO_0001645, EFO_0004629
Diseasevenous thromboembolism, fibrinogen measurement

RAPGEF6 VWF HECTD4 JMJD1C

6.62e-0567954EFO_0004286, EFO_0004623
Diseasefibrinogen measurement, coronary artery disease

JCAD RAPGEF6 HECTD4 JMJD1C ATP2B1

1.44e-04154955EFO_0001645, EFO_0004623
Diseaseserum gamma-glutamyl transferase measurement

JCAD DLG5 CDC42BPA EML4 SEPTIN9 HECTD4 DYRK1A JMJD1C AHNAK ACSS3 BAHCC1

1.73e-049149511EFO_0004532
Diseaseforced expiratory volume

JCAD SETD1A EML4 SEPTIN9 LARP1 ATE1 JMJD1C EML3 AHNAK TNXB

2.30e-047899510EFO_0004314
Diseasefemale breast cancer (is_implicated_in)

RTEL1 POLH

2.84e-048952DOID:0050671 (is_implicated_in)
Diseasemargarate 17:0 measurement

FREM1 ALK

3.64e-049952EFO_0021066
DiseaseEpilepsy

SETD1A FLNA DYRK1A TXNRD1

4.33e-04109954C0014544
Diseasedisorder of pharynx

FOXN1 KLHL1 PIM3

4.44e-0446953MONDO_0020592
Diseasecoronary artery disease

DAB2IP JCAD DPYD HECTD4 CFB PHF1 IGF2BP1 LRP1 PLEKHH2 ATP2B1 TNXB ALK

4.51e-0411949512EFO_0001645
Diseasehypertension

HECTD4 TIAM1 KDM4A ATP2B1 TNXB BAG6

4.83e-04307956EFO_0000537
Diseasefactor VIII measurement, coronary artery disease

DAB2IP JCAD VWF ATP2B1

4.96e-04113954EFO_0001645, EFO_0004630
Diseasecongenital diaphragmatic hernia (implicated_via_orthology)

FREM1 LRP1

6.63e-0412952DOID:3827 (implicated_via_orthology)
DiseaseHerpes Zoster, response to tofacitinib

VWF IGF2BP1

6.63e-0412952EFO_0006510, EFO_0600024
Diseaseinterleukin 12 measurement

POLH DYRK1A JMJD1C

6.74e-0453953EFO_0004753
DiseaseMalignant neoplasm of breast

FLNA FLNB DPYD VWF POLH APC2 SHROOM2 SLC8A3 GALNT5 GEN1 ALK

6.76e-0410749511C0006142
DiseaseIschemic stroke, fibrinogen measurement

RAPGEF6 HECTD4 JMJD1C

7.51e-0455953EFO_0004623, HP_0002140
Diseasemean corpuscular hemoglobin concentration

FOXK2 HECTD4 LARP1 MIDEAS RAB10 BBS7 ERAL1 HECW2 CPEB4 KIF3C DDX39A

8.53e-0411059511EFO_0004528
Diseasefibrinogen measurement, factor VII measurement

RAPGEF6 HECTD4 JMJD1C

8.77e-0458953EFO_0004619, EFO_0004623
Diseasecognitive function measurement, self reported educational attainment

DPYD CLSTN2 JMJD1C IGF2BP1 CLNK TNXB

1.03e-03355956EFO_0004784, EFO_0008354
Diseaseascending aortic diameter

FLNB JMJD1C HMCN1 ATP2B1

1.11e-03140954EFO_0021787
Diseasepeak expiratory flow

JCAD EML4 EML3 PIM3 BBS7 XRN1 LRP1

1.15e-03498957EFO_0009718
Diseasepancreatitis

JCAD HECTD4

1.20e-0316952EFO_0000278
DiseaseCoronary Arteriosclerosis

JCAD HECTD4 ATP2B1

1.22e-0365953C0010054
DiseaseCoronary Artery Disease

JCAD HECTD4 ATP2B1

1.22e-0365953C1956346
Diseaseaortic measurement

JCAD FLNB JMJD1C HMCN1 LRP1

1.33e-03251955EFO_0020865
Diseaseattention function measurement

KLHL1 CDH4 CFAP53 ALK

1.36e-03148954EFO_0007636
Diseasegait measurement

GPHN JMJD1C IGF2BP1 ACSS3

1.43e-03150954EFO_0007680
DiseaseAge-related macular degeneration

CFB HMCN1

1.52e-0318952cv:C0242383
Diseasetonsillectomy risk measurement

FOXN1 RAPGEF6 KLHL1 HECTD4 TNXB

1.55e-03260955EFO_0007924
Diseaseosteochondrodysplasia (is_implicated_in)

FLNA FLNB

1.69e-0319952DOID:2256 (is_implicated_in)
Diseasefactor VIII measurement, Ischemic stroke

VWF HECTD4

1.69e-0319952EFO_0004630, HP_0002140
DiseaseColorectal Carcinoma

DPYD SELENBP1 APC2 CLSTN2 TXNRD1 TIAM1 LRP1 DLG3

1.95e-03702958C0009402
DiseaseSchizophrenia

SETD1A DPYD RAPGEF6 SELENBP1 GRIK5 LRP1 DLG3 TNXB ALK

2.19e-03883959C0036341
DiseaseEpilepsy, Cryptogenic

FLNA DYRK1A TXNRD1

2.38e-0382953C0086237
DiseaseAwakening Epilepsy

FLNA DYRK1A TXNRD1

2.38e-0382953C0751111
DiseaseAura

FLNA DYRK1A TXNRD1

2.38e-0382953C0236018
Diseaseresponse to clopidogrel, cardiovascular event measurement

CDC42BPA FREM1

2.48e-0323952EFO_0006919, GO_1903493
Diseasedescending aortic diameter

JCAD FLNB LRP1

2.91e-0388953EFO_0021788

Protein segments in the cluster

PeptideGeneStartEntry
LGEKPLRIIGVKVHP

ESYT1

186

Q9BSJ8
GKERHKLVLPVPADG

BAHCC1

246

Q9P281
PIHKESGPGEELKIN

BBS7

321

Q8IWZ6
NVGGKVIHLVERAPP

BAG6

76

P46379
LKKNCPHIVVGTPGR

DDX39B

161

Q13838
KKNCPHVVVGTPGRI

DDX39A

161

O00148
GRIKPKPVEVQVVTH

ACTR3B

356

Q9P1U1
VDVPKLEGDLKGPHV

AHNAK

2406

Q09666
KGPKVGIDTPDIDIH

AHNAK

4556

Q09666
TVSHQKGKPVPRIAE

DPYD

856

Q12882
KPPGTRKLHNILGVE

DYRK1A

416

Q13627
KHGPSPGVRAEKETI

CLSTN2

386

Q9H4D0
PEKEGGLPRHVGNKT

ATP2B1

531

P20020
VVPKGKGEQIAREHG

RAB10

131

P61026
KIEEHAPGVPKILVG

RAB40A

111

Q8WXH6
KIEEHAPGVPKILVG

RAB40AL

111

P0C0E4
KHRLVVLVKDNGEPP

PCDHB5

636

Q9Y5E4
PGKVLNGEKVDVRPA

CPSF7

146

Q8N684
GLGVETERPKQKTEP

ITPKC

101

Q96DU7
GIVKLKPHEEPLRSE

PTPN9

76

P43378
ARPGQDIRPIGHDIK

GPHN

451

Q9NQX3
HGPGEQQKRKIVLDP

CFB

251

P00751
RELKPGGANIPVTEK

HECW2

1386

Q9P2P5
GDSPELKPRAVHKQG

DAB2IP

976

Q5VWQ8
LQAEEHGGLVRKKPP

LARP1

16

Q6PKG0
SKVRPPVGGISVKEH

KIAA0100

1991

Q14667
PNNGRIHVGKVLPKT

MAGEB5

116

Q9BZ81
HREVKVKVEPIPAIG

FOXK2

521

Q01167
GPKEEVKLETHIRVP

IGF2BP1

481

Q9NZI8
GLDKPRAITVHPEKG

LRP1

2006

Q07954
LGAHPGPKREVVKGE

JCAD

791

Q9P266
KHQPESEGLVGKIPE

JMJD1C

1151

Q15652
AEAVKIERTHPGLPK

C9orf131

736

Q5VYM1
PGKRLELKENPETGV

KIF3C

161

O14782
HPQKVKVFGPGVERS

FLNB

741

O75369
LDTPGIISPGKQKRH

ERAL1

166

O75616
PKEAPGVSRHLVVKE

FREM1

641

Q5H8C1
EEPRHVKVQKGSEPL

DLG5

1346

Q8TDM6
VPPEHGKRLERLAKG

KDM4A

211

O75164
PGGIGTREVHNKLEK

MNT

216

Q99583
LGPEGHGIKIISKIE

PKLR

301

P30613
PKKPGHILVLLDTEG

GBP1

86

P32455
GKEQHPVKVVSTKRP

HECTD4

3336

Q9Y4D8
IKGIVKDIIHDPGRG

RPL8

41

P62917
KSPSDVIRKPQGHIE

PLEKHH2

736

Q8IVE3
PKIQRGPKHLKVQVG

HMCN1

1171

Q96RW7
KTPHSGAQLGVPREK

NUTM1

1086

Q86Y26
EEEIKKHGSNPVGLP

POTEB3

416

A0JP26
KHRLVVLVKDNGEPP

PCDHB4

636

Q9Y5E5
VIVRSKPPKGQGAEH

CFAP53

21

Q96M91
VGSTLQPPKHRKGRQ

APC2

1726

O95996
HPDRVKARGPGLEKT

FLNA

671

P21333
FGRPVVVPHGKEKEA

GALNT5

441

Q7Z7M9
HKLIRLEEGVPPGTV

CDH4

511

P55283
PHGESEQIGVIPSKK

DLG3

551

Q92796
RHQKIIEEAPAPGIK

MCCC1

281

Q96RQ3
HPEALKREKAGGPQL

MIDEAS

161

Q6PJG2
VKVHTVPKPGKGADL

ATE1

186

O95260
EPVKQHIPLRNLGGK

GEN1

11

Q17RS7
VIVQERKDTKPGVPH

CCDC174

346

Q6PII3
KPLVKEGGDRPRHIS

CPEB4

711

Q17RY0
AGVDKDGKPLQPVVH

EML3

326

Q32P44
GVDKDGRPLQPHVRV

EML4

331

Q9HC35
PKAPLGGIHISETKQ

DIP2A

901

Q14689
PGVKVIIAHTETKGP

DIP2A

1366

Q14689
GEKEIPHIKVGPEET

GRIK5

111

Q16478
EEEIKKHGSNPVGLP

POTEC

416

B2RU33
KGKVEELGPPSAVRN

PHF1

381

O43189
EEEIKKHGSNPVGLP

POTED

416

Q86YR6
VVKRKSALGPGVPHI

POLR1E

291

Q9GZS1
HKSEESIVPRPEGKG

ERMAP

416

Q96PL5
KKIRLVSHPEEPVAG

RTEL1

876

Q9NZ71
DHKVKVTPLGNPDRP

ATP6V1C2

291

Q8NEY4
GIKKHRVTLPGQEEP

URM1

21

Q9BTM9
RTEQEKSGVPHIPKI

RAPGEF6

621

Q8TEU7
DKRTPIVIIKQGHEP

SCIN

686

Q9Y6U3
HGPQVLGSEVKVKPP

FOXN1

191

O15353
PPTIKGVKHLKGQNE

PPP1R1C

76

Q8WVI7
KKKERGHTVTEPIQP

POLR1G

426

O15446
GLKRAEVLGHKTPEP

SEPTIN9

131

Q9UHD8
LKGGREHGEPLVITK

SHROOM2

41

Q13796
VVDVGSEPRAPKLHK

SELENBP1

106

Q13228
SQPEPLVVKGKRVAG

SELENBP1

371

Q13228
EHDPVKPRQLPKTIG

POLH

306

Q9Y253
QPAGKAEGIREPKVT

NOP2

681

P46087
EGHVRIPKPAGVKKG

CDC42BPA

1086

Q5VT25
PPKRDEERGKTQGKH

SETD1A

941

O15047
PIAKKEPHDRGNLGL

ALK

1521

Q9UM73
VPEEVGLKGHLPKLQ

AHNAK2

2226

Q8IVF2
VPEGAGLKEHLPKVE

AHNAK2

3711

Q8IVF2
VPEEAGLKGHLPKVQ

AHNAK2

3876

Q8IVF2
VPEGASLKGHLPKVQ

AHNAK2

4041

Q8IVF2
VVGKEDPLKGHVPLA

ACSS3

586

Q9H6R3
PIILIDGKDKTGVHR

CLNK

396

Q7Z7G1
SAVVPEHGQKTPRKI

TEX44

71

Q53QW1
PVVFVKQRKIGGHGP

TXNRD1

121

Q16881
RSHIKEEGPEGPQRI

TEX13D

451

A0A0J9YY54
SHIKEEGPEGPQRIV

TEX13D

576

A0A0J9YY54
EKRQLGGKDGPPHQV

TSR1

71

Q2NL82
KKKVIVIPVGIGPHA

VWF

1406

P04275
PDGKREKEVVLPNVH

TIAM1

736

Q13009
PKAVRVPGHEDGVTI

TNXB

3101

P22105
HGEDRKVVFQKGPPE

TEX43

91

Q6ZNM6
GRTAPPSKVVHLGDK

XRN1

751

Q8IZH2
GGVDHLPVKILQPAK

PIM3

16

Q86V86
FRGNKIIHIGEKPPA

ZNF705B

271

P0CI00
KIKHPIGTRKGPLEV

WDR93

11

Q6P2C0
GIKVPIEAKINHGRE

ERVK-18

136

P63123
HCGEKPLKRQEGRVP

ZNF419

131

Q96HQ0
GLEHGQPPIERKVIE

USP11

171

P51784
PGPHEKGLVLQELKV

KLHL1

136

Q9NR64
AGRSLGEHLPKIQKP

LCP2

271

Q13094
GKPVLGEHPKLEVII

SLC8A3

656

P57103