Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-specific protease binding	SART3 CLTC PTEN	4.90e-05	20	72	3	GO:1990381
GeneOntologyMolecularFunction	Delta4-3-oxosteroid 5beta-reductase activity	AKR1D1 AKR1C4	1.27e-04	5	72	2	GO:0047787
GeneOntologyMolecularFunction	ketosteroid monooxygenase activity	AKR1D1 AKR1C4	1.27e-04	5	72	2	GO:0047086
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH3 HOOK1 DNAH8	1.38e-04	28	72	3	GO:0051959
GeneOntologyMolecularFunction	methylated histone binding	SPIN1 SPIN2A SPIN2B SPIN3	2.64e-04	86	72	4	GO:0035064
GeneOntologyMolecularFunction	methylation-dependent protein binding	SPIN1 SPIN2A SPIN2B SPIN3	2.88e-04	88	72	4	GO:0140034
GeneOntologyMolecularFunction	enone reductase activity	AKR1D1 AKR1C4	3.54e-04	8	72	2	GO:0035671
GeneOntologyMolecularFunction	histone binding	SART3 SPIN1 SPIN2A SPIN2B STAT1 SPIN3	3.88e-04	265	72	6	GO:0042393
GeneOntologyMolecularFunction	U3 snoRNA binding	UTP25 XRCC5	6.91e-04	11	72	2	GO:0034511
GeneOntologyMolecularFunction	aldose reductase (NADPH) activity	AKR1D1 AKR1C4	1.13e-03	14	72	2	GO:0004032
GeneOntologyBiologicalProcess	alcohol catabolic process	SULT1B1 AKR1D1 AKR1C4 PTEN	2.06e-05	47	71	4	GO:0046164
GeneOntologyCellularComponent	Sin3-type complex	SIN3B SIN3A BRMS1	5.52e-05	22	71	3	GO:0070822
GeneOntologyCellularComponent	clathrin vesicle coat	AP2B1 CLTC AP1M1	2.91e-04	38	71	3	GO:0030125
MousePheno	embryonic lethality between implantation and somite formation, complete penetrance	SART3 STXBP3 UTP25 SIN3A PFKFB3 PTEN MGA ITGB1	2.69e-05	311	55	8	MP:0011096
MousePheno	embryonic lethality between implantation and somite formation	SART3 STXBP3 UTP25 SIN3A PFKFB3 PTEN MGA ITGB1	5.07e-05	340	55	8	MP:0006205
MousePheno	abnormal CD8-positive, naive alpha-beta T cell number	RASGRP1 RABGAP1 XRCC5 STAT1	1.37e-04	67	55	4	MP:0013434
MousePheno	embryonic lethality between implantation and placentation, complete penetrance	SART3 EFL1 STXBP3 UTP25 SIN3A PFKFB3 PTEN MGA ITGB1	1.43e-04	506	55	9	MP:0011095
MousePheno	micrognathia	AP2B1 TGDS LRP2 ITGB1	1.45e-04	68	55	4	MP:0002639
MousePheno	increased circulating lipase level	PACS1 VPS13C RABGAP1	1.96e-04	29	55	3	MP:0011886
MousePheno	abnormal circulating lipase level	PACS1 VPS13C RABGAP1	2.17e-04	30	55	3	MP:0011885
Domain	Spin-Ssty	SPIN1 SPIN2A SPIN2B SPIN3	9.56e-10	5	71	4	PF02513
Domain	SPIN/Ssty	SPIN1 SPIN2A SPIN2B SPIN3	9.56e-10	5	71	4	IPR003671
Domain	HDAC_interact	SIN3B SIN3A	1.42e-05	2	71	2	SM00761
Domain	Sin3_corepress	SIN3B SIN3A	1.42e-05	2	71	2	PF08295
Domain	Sin3_C	SIN3B SIN3A	1.42e-05	2	71	2	IPR031693
Domain	Sin3a_C	SIN3B SIN3A	1.42e-05	2	71	2	PF16879
Domain	SPIN-2	SPIN2A SPIN2B	1.42e-05	2	71	2	IPR029564
Domain	HDAC_interact_dom	SIN3B SIN3A	1.42e-05	2	71	2	IPR013194
Domain	PAH	SIN3B SIN3A	4.26e-05	3	71	2	IPR003822
Domain	-	SIN3B SIN3A	4.26e-05	3	71	2	1.20.1160.11
Domain	PAH	SIN3B SIN3A	4.26e-05	3	71	2	PS51477
Domain	PAH	SIN3B SIN3A	4.26e-05	3	71	2	PF02671
Domain	ALDOKETO_REDUCTASE_1	AKR1D1 AKR1C4	6.29e-04	10	71	2	PS00798
Domain	Aldo/ket_reductase_CS	AKR1D1 AKR1C4	6.29e-04	10	71	2	IPR018170
Domain	Aldo/keto_reductase	AKR1D1 AKR1C4	6.29e-04	10	71	2	IPR020471
Domain	VPS9	ALS2 ANKRD27	6.29e-04	10	71	2	PS51205
Domain	VPS9	ALS2 ANKRD27	6.29e-04	10	71	2	PF02204
Domain	VPS9	ALS2 ANKRD27	6.29e-04	10	71	2	IPR003123
Domain	ALDOKETO_REDUCTASE_2	AKR1D1 AKR1C4	6.29e-04	10	71	2	PS00062
Domain	ALDOKETO_REDUCTASE_3	AKR1D1 AKR1C4	6.29e-04	10	71	2	PS00063
Domain	p53-like_TF_DNA-bd	TBX10 MGA STAT1	1.08e-03	53	71	3	IPR008967
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DNAH8	1.26e-03	14	71	2	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DNAH8	1.26e-03	14	71	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DNAH8	1.26e-03	14	71	2	IPR013602
Domain	DHC_N2	DNAH3 DNAH8	1.26e-03	14	71	2	PF08393
Domain	MT	DNAH3 DNAH8	1.26e-03	14	71	2	PF12777
Domain	AAA_8	DNAH3 DNAH8	1.26e-03	14	71	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH3 DNAH8	1.26e-03	14	71	2	IPR011704
Domain	AAA_5	DNAH3 DNAH8	1.26e-03	14	71	2	PF07728
Domain	DHC_fam	DNAH3 DNAH8	1.45e-03	15	71	2	IPR026983
Domain	Dynein_heavy_dom	DNAH3 DNAH8	1.45e-03	15	71	2	IPR004273
Domain	Dynein_heavy	DNAH3 DNAH8	1.45e-03	15	71	2	PF03028
Domain	-	AKR1D1 AKR1C4	1.65e-03	16	71	2	3.20.20.100
Domain	TF_T-box	TBX10 MGA	1.87e-03	17	71	2	IPR001699
Domain	NADP_OxRdtase_dom	AKR1D1 AKR1C4	1.87e-03	17	71	2	IPR023210
Domain	TBOX	TBX10 MGA	1.87e-03	17	71	2	SM00425
Domain	TF_T-box_CS	TBX10 MGA	1.87e-03	17	71	2	IPR018186
Domain	-	TBX10 MGA	1.87e-03	17	71	2	2.60.40.820
Domain	TBOX_3	TBX10 MGA	1.87e-03	17	71	2	PS50252
Domain	Aldo_ket_red	AKR1D1 AKR1C4	1.87e-03	17	71	2	PF00248
Domain	T-box	TBX10 MGA	1.87e-03	17	71	2	PF00907
Domain	Aldo/ket_red/Kv-b	AKR1D1 AKR1C4	1.87e-03	17	71	2	IPR001395
Domain	TBOX_1	TBX10 MGA	1.87e-03	17	71	2	PS01283
Domain	TBOX_2	TBX10 MGA	1.87e-03	17	71	2	PS01264
Pathway	REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS	PACS1 AP2B1 AP1M1	7.92e-05	21	57	3	M12347
Pathway	REACTOME_L1CAM_INTERACTIONS	AP2B1 CSNK2A2 CLTC ITGB1	1.61e-04	68	57	4	MM14968
Pathway	REACTOME_VIRAL_INFECTION_PATHWAYS	ANO4 PACS1 AP2B1 CSNK1A1 CSNK2A2 CLTC AP1M1 XRCC5 ITGB1 MGAT4C STAT1 BRMS1	1.84e-04	888	57	12	M48034
Pathway	WP_T_CELL_RECEPTOR_AND_COSTIMULATORY_SIGNALING	RASGRP1 CSNK1A1 PTEN	1.91e-04	28	57	3	M39632
Pathway	REACTOME_THE_ROLE_OF_NEF_IN_HIV_1_REPLICATION_AND_DISEASE_PATHOGENESIS	PACS1 AP2B1 AP1M1	1.91e-04	28	57	3	M11362
Pubmed	A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1.	SPIN1 SPIN2A SPIN2B SPIN3	2.52e-10	6	72	4	29061846
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CCND3 PACS1 DPP6 MID2 UBAP2L CSNK1A1 SPIN1 VPS13C TM7SF3 RABGAP1 XRCC5 PTEN ARHGAP8 FBXO21 ITGB1 BAIAP3 PLEKHM1 BRMS1	9.68e-10	1489	72	18	28611215
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	PACS1 NRDE2 UBAP2L SPIN1 PRAMEF14 CSNK2A2 CLTC LRP2 ALS2 AKR1C4 PRAMEF1 MGA ITGB1 BAIAP3 STAT1	5.07e-09	1084	72	15	11544199
Pubmed	Foxk1 recruits the Sds3 complex and represses gene expression in myogenic progenitors.	SIN3B CSNK2A2 SIN3A	2.96e-07	7	72	3	22716292
Pubmed	Functional specialization of beta-arrestin interactions revealed by proteomic analysis.	DNAH3 AP2B1 SPIN1 CLTC PFKFB3 XRCC5 STAT1 SPIN3	3.15e-07	317	72	8	17620599
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	SIN3B PDK3 SPIN1 CLTC SIN3A PFKFB3 XRCC5 MGA GTF3C3 BRMS1	3.42e-07	583	72	10	29844126
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	CCND3 NRDE2 MYH7 UTP25 AP2B1 HAGHL CSNK1A1 CSNK2A2 CNGB3 PIP4K2B SIN3A MERTK	3.48e-07	910	72	12	36736316
Pubmed	Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription.	SIN3B SIN3A BRMS1	1.39e-06	11	72	3	14581478
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	SART3 NRDE2 RASGRP1 MYH7 HOOK1 AP2B1 RHPN2 CSNK2A2 CLTC ALS2 PFKFB3 GTF3C3 STAT1	2.08e-06	1284	72	13	17353931
Pubmed	EphrinA2 regulates clathrin mediated KSHV endocytosis in fibroblast cells by coordinating integrin-associated signaling and c-Cbl directed polyubiquitination.	AP2B1 CLTC ITGB1	2.40e-06	13	72	3	23874206
Pubmed	Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.	AKR1D1 AKR1C4	4.23e-06	2	72	2	19013211
Pubmed	The C-terminal putative nuclear localization sequence of breast cancer metastasis suppressor 1, BRMS1, is necessary for metastasis suppression.	SIN3A BRMS1	4.23e-06	2	72	2	23390556
Pubmed	Protein kinase CK2/PTEN pathway plays a key role in platelet-activating factor-mediated murine anaphylactic shock.	CSNK2A2 PTEN	4.23e-06	2	72	2	21531890
Pubmed	Functional domain mapping of the clathrin-associated adaptor medium chains mu1 and mu2.	AP2B1 AP1M1	4.23e-06	2	72	2	9341158
Pubmed	Decreased Expressions of CK1α and PTEN in Sinonasal Inverted Papilloma.	CSNK1A1 PTEN	4.23e-06	2	72	2	35588152
Pubmed	The mammalian Sin3 proteins are required for muscle development and sarcomere specification.	SIN3B SIN3A	4.23e-06	2	72	2	20956564
Pubmed	Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression.	SPIN2A SPIN2B	4.23e-06	2	72	2	12145692
Pubmed	Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing Senescence.	SIN3B PTEN	4.23e-06	2	72	2	28807943
Pubmed	Differential Complex Formation via Paralogs in the Human Sin3 Protein Interaction Network.	SIN3B SIN3A	4.23e-06	2	72	2	32467258
Pubmed	SIN3A and SIN3B differentially regulate breast cancer metastasis.	SIN3B SIN3A	4.23e-06	2	72	2	27780928
Pubmed	Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor.	PCGF2 CSNK2A2 XRCC5 MGA	6.14e-06	57	72	4	17296600
Pubmed	Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex.	SIN3B SIN3A BRMS1	8.05e-06	19	72	3	22984288
Pubmed	Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.	SIN3B SIN3A BRMS1	8.05e-06	19	72	3	28554894
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	SIN3B PCGF2 CSNK2A2 SIN3A MGA FBXO21 ANKRD27 BRMS1	8.58e-06	495	72	8	27705803
Pubmed	Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.	AP2B1 CLTC	1.27e-05	3	72	2	19509056
Pubmed	The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis.	SIN3B SIN3A	1.27e-05	3	72	2	22101514
Pubmed	Sin3 interacts with Foxk1 and regulates myogenic progenitors.	SIN3B SIN3A	1.27e-05	3	72	2	22476904
Pubmed	A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.	SIN3B SIN3A	1.27e-05	3	72	2	9139820
Pubmed	Erythrocyte and leukocyte dynamics in the retinal capillaries of diabetic mice.	ITGB1 STAT1	1.27e-05	3	72	2	12957148
Pubmed	The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.	AP2B1 CLTC	1.27e-05	3	72	2	10097102
Pubmed	The highly conserved region of the co-repressor Sin3A functionally interacts with the co-repressor Alien.	SIN3B SIN3A	1.27e-05	3	72	2	15173382
Pubmed	Interference with Sin3 function induces epigenetic reprogramming and differentiation in breast cancer cells.	SIN3B SIN3A	1.27e-05	3	72	2	20547842
Pubmed	Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism.	AKR1D1 AKR1C4	1.27e-05	3	72	2	24189185
Pubmed	SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex.	SIN3B SIN3A BRMS1	1.46e-05	23	72	3	9651585
Pubmed	Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1-AKT axis-mediated glycolysis.	UBAP2L CSNK1A1 PFKFB3 SKA3	1.56e-05	72	72	4	33106477
Pubmed	Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.	UBAP2L CLTC SIN3A XRCC5 STAT1	1.65e-05	152	72	5	16009940
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SIN3B UBAP2L CLTC SIN3A SKA3 MGA GTF3C3 STAT1	1.81e-05	549	72	8	38280479
Pubmed	WDFY4 is required for cross-presentation in response to viral and tumor antigens.	AP2B1 SPIN1 VPS13C CLTC PFKFB3	1.87e-05	156	72	5	30409884
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	SART3 NRDE2 AP2B1 UBAP2L SPIN1 CSNK2A2 CLTC XRCC5 FBXO21 ITGB1 GTF3C3 STAT1	2.31e-05	1371	72	12	36244648
Pubmed	Structure--function relationships in HIV-1 Nef.	PACS1 AP2B1 AP1M1	2.40e-05	27	72	3	11463741
Pubmed	Phosphorylation of the beta-galactoside-binding protein galectin-3 modulates binding to its ligands.	CSNK1A1 CSNK2A2	2.53e-05	4	72	2	10961987
Pubmed	Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia.	PACS1 CSNK2A2	2.53e-05	4	72	2	16308564
Pubmed	AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1.	PACS1 AP1M1	2.53e-05	4	72	2	14608369
Pubmed	Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression.	SIN3B SIN3A	2.53e-05	4	72	2	9139821
Pubmed	Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes.	SIN3B SIN3A	2.53e-05	4	72	2	10570134
Pubmed	Survival motor neuron (SMN) protein interacts with transcription corepressor mSin3A.	SIN3B SIN3A	2.53e-05	4	72	2	14749338
Pubmed	CK2α' Drives Lung Cancer Metastasis by Targeting BRMS1 Nuclear Export and Degradation.	CSNK2A2 BRMS1	2.53e-05	4	72	2	26980766
Pubmed	Mnt transcriptional repressor is functionally regulated during cell cycle progression.	SIN3B SIN3A	2.53e-05	4	72	2	16103876
Pubmed	Phosphorylation of a vesicular monoamine transporter by casein kinase II.	CSNK1A1 CSNK2A2	2.53e-05	4	72	2	9045708
Pubmed	Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential.	SIN3B SIN3A	2.53e-05	4	72	2	15467743
Pubmed	Nef-mediated clathrin-coated pit formation.	CLTC AP1M1	2.53e-05	4	72	2	9314527
Pubmed	The intracellular domain of L1CAM binds to casein kinase 2α and is neuroprotective via inhibition of the tumor suppressors PTEN and p53.	CSNK2A2 PTEN	2.53e-05	4	72	2	25727698
Pubmed	Direct identification of PTEN phosphorylation sites.	CSNK2A2 PTEN	2.53e-05	4	72	2	12297295
Pubmed	Detailed structural-functional analysis of the Krüppel-like factor 16 (KLF16) transcription factor reveals novel mechanisms for silencing Sp/KLF sites involved in metabolism and endocrinology.	SIN3B SIN3A	2.53e-05	4	72	2	22203677
Pubmed	Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.	AP2B1 CLTC	2.53e-05	4	72	2	17267500
Pubmed	Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction.	MERTK STAT1	2.53e-05	4	72	2	33529176
Pubmed	Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages.	MERTK STAT1	2.53e-05	4	72	2	27406916
Pubmed	STAT1 Inhibits MiR-181a Expression to Suppress Colorectal Cancer Cell Proliferation Through PTEN/Akt.	PTEN STAT1	2.53e-05	4	72	2	28322462
Pubmed	Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-κB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury.	MERTK STAT1	2.53e-05	4	72	2	22427680
Pubmed	Role of EphA4 and EphrinB3 in local neuronal circuits that control walking.	SIN3B SIN3A	2.53e-05	4	72	2	12649481
Pubmed	L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I.	CSNK1A1 CSNK2A2	2.53e-05	4	72	2	8253806
Pubmed	Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.	CCND3 ITGB1 STAT1	2.99e-05	29	72	3	14522949
Pubmed	The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes.	CSNK1A1 CSNK2A2 CLTC PIP4K2B	3.15e-05	86	72	4	26885983
Pubmed	Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex.	SIN3B SIN3A BRMS1	3.32e-05	30	72	3	16449650
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SART3 UTP25 UBAP2L CSNK2A2 CLTC XRCC5 GTF3C3	3.59e-05	440	72	7	34244565
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	AP2B1 PDK3 CLTC XRCC5 ITGB1	3.91e-05	182	72	5	31067453
Pubmed	ARF6 regulates angiotensin II type 1 receptor endocytosis by controlling the recruitment of AP-2 and clathrin.	AP2B1 CLTC	4.21e-05	5	72	2	17719203
Pubmed	Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex.	SIN3B SIN3A	4.21e-05	5	72	2	16166625
Pubmed	Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3.	SIN3B SIN3A	4.21e-05	5	72	2	7889570
Pubmed	Metastatic properties of prostate cancer cells are controlled by VEGF.	PTEN ITGB1	4.21e-05	5	72	2	15500293
Pubmed	Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein.	SIN3B SIN3A	4.21e-05	5	72	2	9627120
Pubmed	ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2.	AP2B1 CLTC	4.21e-05	5	72	2	12221107
Pubmed	Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription.	SIN3B SIN3A	4.21e-05	5	72	2	15489224
Pubmed	α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism.	PTEN ITGB1	4.21e-05	5	72	2	27092791
Pubmed	Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases.	CCND3 PFKFB3	4.21e-05	5	72	2	19473963
Pubmed	Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer.	PTEN STAT1	4.21e-05	5	72	2	29530483
Pubmed	Novel binding sites on clathrin and adaptors regulate distinct aspects of coat assembly.	AP2B1 CLTC	4.21e-05	5	72	2	17052248
Pubmed	Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation.	SIN3B SIN3A	4.21e-05	5	72	2	18451802
Pubmed	Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.	AP2B1 CSNK1A1 AP1M1 PFKFB3 XRCC5 STAT1	5.72e-05	323	72	6	24797263
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	SART3 UTP25 AP2B1 UBAP2L CSNK2A2 CLTC XRCC5 GTF3C3	6.16e-05	653	72	8	22586326
Pubmed	Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling.	SIN3B SIN3A	6.31e-05	6	72	2	29056338
Pubmed	microRNA-875-5p plays critical role for mesenchymal condensation in epithelial-mesenchymal interaction during tooth development.	PTEN STAT1	6.31e-05	6	72	2	32188878
Pubmed	Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8.	CSNK1A1 CSNK2A2	6.31e-05	6	72	2	11583622
Pubmed	The Mad1-Sin3B interaction involves a novel helical fold.	SIN3B SIN3A	6.31e-05	6	72	2	11101889
Pubmed	Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex.	SIN3B SIN3A	6.31e-05	6	72	2	11909966
Pubmed	Cdk5 phosphorylates a component of the HDAC complex and regulates histone acetylation during neuronal cell death.	SIN3B SIN3A	6.31e-05	6	72	2	22398430
Pubmed	Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites.	AP2B1 CLTC	6.31e-05	6	72	2	10748223
Pubmed	Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin.	AP2B1 CLTC	6.31e-05	6	72	2	12732633
Pubmed	Histone deacetylase 1 can repress transcription by binding to Sp1.	SIN3B SIN3A	6.31e-05	6	72	2	10409740
Pubmed	An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B.	SIN3B SIN3A	6.31e-05	6	72	2	12398767
Pubmed	Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo.	AP2B1 CLTC	6.31e-05	6	72	2	15533940
Pubmed	Homo-oligomerisation and nuclear localisation of mouse histone deacetylase 1.	SIN3B SIN3A	6.31e-05	6	72	2	11302704
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	UTP25 AP2B1 UBAP2L CLTC SPIN2A XRCC5 GTF3C3	6.45e-05	483	72	7	36912080
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	SART3 SIN3B MYH7 SIN3A MGA ITGB1 GTF3C3 STAT1 BRMS1	6.82e-05	857	72	9	25609649
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	AP2B1 CSNK1A1 CSNK2A2 CLTC XRCC5 ITGB1	7.58e-05	340	72	6	24332808
Pubmed	PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.	PCGF2 CSNK2A2 MGA	8.57e-05	41	72	3	22325352
Pubmed	Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.	SIN3B SIN3A	8.82e-05	7	72	2	10357820
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH3 DNAH8	8.82e-05	7	72	2	9256245
Pubmed	Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin.	MYH7 ITGB1	8.82e-05	7	72	2	9004034
Pubmed	Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression.	CCND3 PTEN	8.82e-05	7	72	2	23109711
Interaction	MXD1 interactions	SIN3B SIN3A PTEN MGA BRMS1	4.80e-07	45	70	5	int:MXD1
Interaction	ARRB2 interactions	UTP25 AP2B1 CSNK1A1 SPIN1 CSNK2A2 CLTC PFKFB3 XRCC5 STAT1 SPIN3	3.61e-06	454	70	10	int:ARRB2
Interaction	SUDS3 interactions	SIN3B CSNK2A2 SIN3A PTEN GTF3C3 BRMS1	9.57e-06	141	70	6	int:SUDS3
Interaction	DEFB107A interactions	SPIN1 SPIN2B SPIN3	1.12e-05	13	70	3	int:DEFB107A
Interaction	HAGHL interactions	HAGHL CSNK2A2 PTEN	1.12e-05	13	70	3	int:HAGHL
Interaction	CSNK2A1 interactions	SART3 PACS1 PCGF2 SNCAIP HAGHL CSNK2A2 PIP4K2B SIN3A XRCC5 PTEN MGA GTF3C3 BRMS1	2.18e-05	956	70	13	int:CSNK2A1
Interaction	CSNK2A2 interactions	SART3 PCGF2 HAGHL CSNK2A2 CLTC AP1M1 PIP4K2B SIN3A PTEN MGA GTF3C3	3.47e-05	718	70	11	int:CSNK2A2
Interaction	ARL6IP4 interactions	CSNK2A2 AP1M1 PIP4K2B SKA3 ITGB1	3.86e-05	109	70	5	int:ARL6IP4
Interaction	CDY2A interactions	SPIN1 SPIN2A SPIN3	5.10e-05	21	70	3	int:CDY2A
Interaction	YAF2 interactions	PCGF2 CSNK2A2 XRCC5 PTEN MGA STAT1	6.30e-05	197	70	6	int:YAF2
Interaction	ARRB1 interactions	DNAH3 AP2B1 SPIN1 CLTC PFKFB3 XRCC5 PTEN	8.82e-05	304	70	7	int:ARRB1
Interaction	CIC interactions	SIN3B PDK3 SPIN1 CLTC SIN3A PFKFB3 XRCC5 MGA GTF3C3 BRMS1	1.05e-04	673	70	10	int:CIC
Interaction	SMURF1 interactions	AP2B1 RHPN2 SPIN1 CSNK2A2 CLTC XRCC5 PTEN FBXO21 STAT1	1.07e-04	544	70	9	int:SMURF1
Interaction	WDFY4 interactions	AP2B1 SPIN1 VPS13C CLTC PFKFB3	1.31e-04	141	70	5	int:WDFY4
Interaction	AP1M1 interactions	HOOK1 AP2B1 MID2 CSNK2A2 AP1M1 PTEN	1.34e-04	226	70	6	int:AP1M1
Interaction	SAP25 interactions	SIN3B SIN3A BRMS1	1.37e-04	29	70	3	int:SAP25
Interaction	SNCA interactions	SART3 SNCAIP STXBP3 UBAP2L CSNK1A1 VPS13C CSNK2A2 CLTC SIN3A STAT1	1.74e-04	716	70	10	int:SNCA
Interaction	LAMTOR1 interactions	AP2B1 CSNK1A1 VPS13C CLTC LRP2 RABGAP1 XRCC5 ITGB1 ANKRD27 PLEKHM1	1.86e-04	722	70	10	int:LAMTOR1
Interaction	ATG5 interactions	AP2B1 HAGHL VPS13C CLTC AP1M1 RABGAP1 STAT1	1.89e-04	344	70	7	int:ATG5
Interaction	BCR interactions	NRDE2 AP2B1 CSNK1A1 CSNK2A2 SIN3A GTF3C3	2.03e-04	244	70	6	int:BCR
Cytoband	Xp11.1	SPIN2A SPIN2B	1.45e-05	4	72	2	Xp11.1
Cytoband	10p15.1	AKR1C4 PFKFB3	8.93e-04	28	72	2	10p15.1
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	PCGF2 AP2B1 PIP4K2B	1.70e-03	149	72	3	chr17q12
Cytoband	19q13.11	RHPN2 ANKRD27	2.30e-03	45	72	2	19q13.11
Cytoband	15q14	RASGRP1 MGA	2.72e-03	49	72	2	15q14
Cytoband	2q33.1	ALS2 GTF3C3	2.94e-03	51	72	2	2q33.1
Cytoband	1p36.21	PRAMEF14 PRAMEF1	4.45e-03	63	72	2	1p36.21
GeneFamily	Tudor domain containing\|Spindlin family	SPIN1 SPIN2A SPIN2B SPIN3	2.18e-10	5	48	4	1089
GeneFamily	Tudor domain containing	SPIN1 SPIN2A SPIN2B SPIN3	2.71e-06	37	48	4	780
GeneFamily	Histone deacetylases, class I\|EMSY complex\|NuRD complex\|SIN3 histone deacetylase complex	SIN3B SIN3A	2.46e-04	9	48	2	1306
GeneFamily	VPS9 domain containing	ALS2 ANKRD27	3.06e-04	10	48	2	928
GeneFamily	Histone deacetylases, class I\|EMSY complex\|NuRD complex\|SIN3 histone deacetylase complex	SIN3B SIN3A	4.48e-04	12	48	2	1243
GeneFamily	Aldo-keto reductases	AKR1D1 AKR1C4	7.09e-04	15	48	2	399
GeneFamily	Dyneins, axonemal	DNAH3 DNAH8	9.15e-04	17	48	2	536
GeneFamily	T-boxes	TBX10 MGA	1.03e-03	18	48	2	766
GeneFamily	PRAME family	PRAMEF14 PRAMEF1	1.84e-03	24	48	2	686
Coexpression	GSE41867_DAY6_EFFECTOR_VS_DAY30_EXHAUSTED_CD8_TCELL_LCMV_CLONE13_UP	CCND3 SIN3B CCRL2 ALS2 ARHGAP8 STAT1	1.88e-05	200	72	6	M9489
Coexpression	GSE17721_PAM3CSK4_VS_GADIQUIMOD_2H_BMDC_DN	CCND3 NRDE2 EFL1 TM7SF3 LRP2 MERTK	1.88e-05	200	72	6	M3965
Drug	lithium indium	SPIN2A SPIN2B	9.86e-06	2	72	2	CID011116062
Drug	scandium phosphate	SPIN2A SPIN2B	9.86e-06	2	72	2	CID006365269
Drug	NSC79098	AKR1D1 AKR1C4	9.86e-06	2	72	2	CID000254632
Drug	rubidium nitrate	SPIN2A SPIN2B	9.86e-06	2	72	2	CID000025731
Drug	C05473	AKR1D1 AKR1C4	9.86e-06	2	72	2	CID000440694
Drug	Metribolone	CSNK1A1 SPIN1 CLTC PIP4K2B XRCC5 PTEN ITGB1 BRMS1	2.74e-05	382	72	8	ctd:D015741
Drug	LY 294002; Down 200; 10uM; MCF7; HT_HG-U133A	PACS1 RASGRP1 PCGF2 MID2 UBAP2L PIP4K2B	2.74e-05	186	72	6	6953_DN
Drug	AC1L99QZ	AKR1D1 AKR1C4	2.95e-05	3	72	2	CID000440678
Drug	Amprolium hydrochloride [137-88-2]; Down 200; 12.6uM; HL60; HG-U133A	STXBP3 UBAP2L CSNK1A1 SPIN1 PFKFB3 VCPKMT	3.57e-05	195	72	6	1979_DN
Drug	Antipyrine, 4-hydroxy [1672-63-5]; Down 200; 19.6uM; MCF7; HT_HG-U133A	DNAH3 HOOK1 CSNK2A2 TM7SF3 CNGB3 STAT1	3.78e-05	197	72	6	1497_DN
Drug	DHBT	AP2B1 CSNK2A2 CLTC AP1M1 MERTK	3.79e-05	119	72	5	CID000001855
Drug	Isradipine [75695-93-1]; Up 200; 10.8uM; PC3; HT_HG-U133A	NRDE2 SULT1B1 CNGB3 LRP2 AKR1C4 BAIAP3	3.89e-05	198	72	6	6347_UP
Drug	Mianserine hydrochloride [21535-47-7]; Down 200; 13.2uM; MCF7; HT_HG-U133A	PACS1 EFL1 DNAH3 VPS13C PIP4K2B VCPKMT	3.89e-05	198	72	6	6260_DN
Drug	Sid 7808	AKR1D1 AKR1C4	5.89e-05	4	72	2	CID000000140
Drug	diphenylketen	SPIN2A SPIN2B	5.89e-05	4	72	2	CID000013696
Disease	angiomyolipoma (is_marker_for)	PTEN STAT1	5.68e-05	5	71	2	DOID:3314 (is_marker_for)
Disease	Paranoia	AKR1C4 DNAH8	3.10e-04	11	71	2	C1456784
Disease	cancer (implicated_via_orthology)	SIN3B PIP4K2B SIN3A PTEN ITGB1	4.75e-04	268	71	5	DOID:162 (implicated_via_orthology)
Disease	Craniofacial Abnormalities	CSNK1A1 LRP2 SIN3A PTEN	5.55e-04	156	71	4	C0376634
Disease	Intellectual Disability	PACS1 PCGF2 LRP2 SIN3A PTEN GTF3C3	7.29e-04	447	71	6	C3714756
Disease	Dermatologic disorders	CCRL2 PFKFB3 PTEN	7.96e-04	75	71	3	C0037274
Disease	Manic	PACS1 AKR1C4 DNAH8	8.92e-04	78	71	3	C0338831
Disease	Neoplasm Metastasis	PTEN ITGB1 STAT1 BRMS1	1.88e-03	217	71	4	C0027627
Disease	Bell's palsy	MGA DNAH8 MGAT4C	1.93e-03	102	71	3	EFO_0007167
Disease	Child Development Disorders, Specific	LRP2 PTEN	2.22e-03	29	71	2	C0085997
Disease	Child Development Deviations	LRP2 PTEN	2.22e-03	29	71	2	C0085996
Disease	Developmental Disabilities	LRP2 PTEN	2.38e-03	30	71	2	C0008073

Protein segments in the cluster

Peptide	Gene	Start	Entry
LQLDYVDLYLLHFPM	AKR1C4	106	P17516
MANYTLAPEDEYDVL	CCRL2	1	O00421
EVFPLAMNYLDRYLS	CCND3	76	P30281
FLELLPKDSDYYNML	AP2B1	266	P63010
LAPEEVEMLYEEALY	BAIAP3	131	O94812
YPPLFMLYALDNDRE	ALS2	1486	Q96Q42
LDYVDLYIIEVPMAF	AKR1D1	111	P51857
DYDPLYKEALQMLRD	APOBEC3A	131	P31941
ENLYLLMGRELEYLE	EFL1	561	Q7Z2Z2
DLISLYEAMPDYLED	RASGRP1	361	O95267
YELLDELMDFGYPQT	AP1M1	111	Q9BXS5
LQPMNAYGLFDEYLE	ANO4	701	Q32M45
FQDYLLMDTVYPAIA	DISP1	496	Q96F81
IPVLEDNYMYLVIEE	HAGHL	6	Q6PII5
KRAEDYPIDLYYLMD	ITGB1	136	P05556
ELLDMLLITNNPYDY	MYH7	296	P12883
MALYDEDLLKNPFYL	ANKRD27	1	Q96NW4
LMQEYIPDLYNHFLD	RABGAP1	701	Q9Y3P9
SLDLYLAMYPDQVQL	FBXO21	411	O94952
LLFMNLYIEDSYVLE	MGAT4C	36	Q9UBM8
LMADCIYYEESLEPL	VCPKMT	141	Q9H867
MLAELEYLPTYIENS	MGA	501	Q8IWI9
QPEDCLDELYEIMYS	MERTK	821	Q12866
LAYFLDKSAEEMPYL	PFKFB3	396	Q16875
ETVELLQPYFNMDDY	DNAH8	3241	Q96JB1
YLDAVEYFPDEMQEI	NRDE2	1126	Q9H7Z3
LLIEYEDMFPYEGPL	HEXD	41	Q8WVB3
AMNPYSLDIFEDQLY	LRP2	4271	P98164
LDELYDSLEMYNPSD	PACS1	366	Q6VY07
LYEDEPLKEYYTLMD	PCGF2	196	P35227
SDYISPLDDLAFDMY	CEP104	191	O60308
LIDDYSMVRFLPYDQ	GPN3	221	Q9UHW5
MNPNLEDFHYDYIDL	CCDC141	1126	Q6ZP82
LEFLMDYADLPYQIE	DNAH3	751	Q8TD57
PELLVDYQMYDYSLD	CSNK2A2	201	P19784
YENLAAEIMPVEYRE	HOOK1	451	Q9UJC3
YRDIEIDDYNLPMQI	DPP6	596	P42658
AIPLYDMEATFAEYE	SART3	256	Q15020
MSTYLLPILIFDNDY	CDH9	561	Q9ULB4
EPRLNYLDLKYSDMF	MAP3K19	636	Q56UN5
FDLDLTYIYPNIIAM	PTEN	21	P60484
EPDAIKESLLYLYMD	PLEKHM1	681	Q9Y4G2
ELFLIMNSYRDLFYP	UTP25	281	Q68CQ4
LYDDSFPMEIRQYLA	STAT1	21	P42224
ENLELTYGYLLEEDM	PRAMEF14	296	Q5SWL7
LRFEEAPDYMYLRQL	CSNK1A1	266	P48729
EVYFMAIIDILTPYD	PIP4K2B	361	P78356
EDYYPAFLDMVRSLL	SIN3A	956	Q96ST3
EVELEEYYPAFLDMV	SIN3B	841	O75182
EYYPAFLDMVRSLLE	SIN3B	846	O75182
YDLDMDEILDVPYIK	SNCAIP	146	Q9Y6H5
YEKDPVLYMYQLLDD	SPIN2A	166	Q99865
ENLELTYGYLLEEDM	PRAMEF1	296	O95521
AMAYDLLPIENDTYK	STXBP3	256	O00186
MLCEQYYLVAPELEV	PDK3	206	Q15120
GYLYEDEIADLMDLR	RHPN2	141	Q8IUC4
EHPILFLYYEDMKEN	SULT1B1	186	O43704
LAYEPFSTLAMIYED	GTF3C3	181	Q9Y5Q9
PYIVYMLQEIDILED	BRMS1	211	Q9HCU9
MEYINRLDNYDAPDI	CLTC	1041	Q00610
ADIICDIIYLYDMLF	CNGB3	256	Q9NQW8
YALLMDFIPLDDKRY	TBX10	111	O75333
SLVEDYPNYMIINLD	TGDS	36	O95455
FEDYPMRILYDLHSE	SKA3	36	Q8IX90
DDLQMLQTRFPLDYY	UBAP2L	821	Q14157
EKDPVLYMYQLLDDY	SPIN1	171	Q9Y657
YEKDPVLYMYQLLDD	SPIN3	166	Q5JUX0
YEKDPVLYMYQLLDD	SPIN2B	166	Q9BPZ2
PQYLSMIDLLESVDY	VPS13C	336	Q709C8
PLNMFTELLIEYYEK	ARHGAP8	396	P85298
VLLDYDNNMLSFYDP	MID2	656	Q9UJV3
YECLVYVQLPFMEDL	XRCC5	416	P13010
VYQYFLPENDLTEEM	TM7SF3	196	Q9NS93