Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF729 NKX6-3 ZSCAN20 ZNF354A KLF7 ZKSCAN1 NFE2L2 GLI1 GLI3 ZNF177 GLIS2 ADNP2 GLIS3 ZNF429 ZNF727 ZNF561 ZSCAN16 ZNF699 ZNF91 ZNF782 ZNF333 ZNF714 ZNF726 GLIS1 ZNF639	4.08e-12	1412	70	25	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF729 STOX2 NKX6-3 ZSCAN20 ZNF354A KLF7 ZKSCAN1 NFE2L2 GLI1 GLI3 ZNF177 GLIS2 GLIS3 ZNF429 ZNF727 ZNF561 ZSCAN16 ZNF699 ZNF91 ZNF782 ZNF333 ZNF714 ZNF726 GLIS1 ZNF639	8.35e-12	1459	70	25	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF729 NKX6-3 ZSCAN20 ZNF354A KLF7 ZKSCAN1 NFE2L2 GLI1 GLI3 GLIS2 GLIS3 ZNF429 ZNF727 ZNF561 ZSCAN16 ZNF699 ZNF91 ZNF782 ZNF333 ZNF714 ZNF726 GLIS1 ZNF639	1.63e-11	1244	70	23	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF729 NKX6-3 ZSCAN20 ZNF354A KLF7 ZKSCAN1 NFE2L2 GLI1 GLI3 GLIS2 GLIS3 ZNF429 ZNF727 ZNF561 ZSCAN16 ZNF699 ZNF91 ZNF782 ZNF333 ZNF714 ZNF726 GLIS1 ZNF639	2.51e-11	1271	70	23	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF729 NKX6-3 KLF7 NFE2L2 GLI1 GLIS2 GLIS3 ZNF727 ZNF699 ZNF91 ZNF782 ZNF726 GLIS1 ZNF639	7.23e-09	560	70	14	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF729 NKX6-3 KLF7 NFE2L2 GLI1 GLIS2 GLIS3 ZNF727 ZNF699 ZNF91 ZNF782 ZNF726 GLIS1 ZNF639	8.27e-09	566	70	14	GO:0001216
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF729 NKX6-3 GLIS3 ZNF727 ZNF699 ZNF91 ZNF782 ZNF726 GLIS1	1.72e-06	320	70	9	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF729 NKX6-3 GLIS3 ZNF727 ZNF699 ZNF91 ZNF782 ZNF726 GLIS1	2.00e-06	326	70	9	GO:0001217
GeneOntologyMolecularFunction	damaged DNA binding	XPC ZNF699 ZNF782 POLQ	2.16e-04	84	70	4	GO:0003684
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	ZNF729 NKX6-3 ZNF354A KLF7 MCPH1 GLI3 ZNF177 GLIS2 GLIS3 CIR1 ZNF429 ZNF699 ZNF91 ZNF726 GLIS1 NEDD4	4.29e-07	1053	71	16	GO:0000122
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	ZNF729 NKX6-3 ZNF354A KLF7 MCPH1 GLI3 ZNF177 GLIS2 GLIS3 CIR1 ZNF429 ZNF699 ZNF91 ZNF726 GLIS1 ZNF639 NEDD4	3.83e-06	1399	71	17	GO:0045892
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	ZNF729 NKX6-3 ZNF354A KLF7 MCPH1 GLI3 ZNF177 GLIS2 GLIS3 CIR1 ZNF429 ZNF699 ZNF91 ZNF726 GLIS1 ZNF639 NEDD4	4.38e-06	1413	71	17	GO:1902679
GeneOntologyBiologicalProcess	transposable element silencing	ZNF729 TEX15 ZNF91 ZNF726	1.89e-05	46	71	4	GO:0010526
GeneOntologyBiologicalProcess	retrotransposition	ZNF729 TEX15 ZNF91 ZNF726	2.24e-05	48	71	4	GO:0032197
GeneOntologyBiologicalProcess	transposition	ZNF729 TEX15 ZNF91 ZNF726	2.63e-05	50	71	4	GO:0032196
GeneOntologyCellularComponent	GLI-SUFU complex	GLI1 GLI3	6.99e-05	4	72	2	GO:1990788
Domain	ZINC_FINGER_C2H2_2	ZNF729 ZSCAN20 ZNF354A KLF7 ZKSCAN1 GLI1 GLI3 ZNF177 GLIS2 SCAPER ADNP2 GLIS3 ZNF429 ZNF727 ZNF561 ZSCAN16 ZNF699 GPATCH8 ZNF91 ZNF782 ZNF333 ZNF714 ZNF726 GLIS1 ZNF687 ZNF639	1.53e-18	775	70	26	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF729 ZSCAN20 ZNF354A KLF7 ZKSCAN1 GLI1 GLI3 ZNF177 GLIS2 SCAPER ADNP2 GLIS3 ZNF429 ZNF727 ZNF561 ZSCAN16 ZNF699 GPATCH8 ZNF91 ZNF782 ZNF333 ZNF714 ZNF726 GLIS1 ZNF687 ZNF639	1.63e-18	777	70	26	PS00028
Domain	Znf_C2H2-like	ZNF729 ZSCAN20 ZNF354A KLF7 ZKSCAN1 GLI1 GLI3 ZNF177 GLIS2 SCAPER ADNP2 GLIS3 ZNF429 ZNF727 ZNF561 ZSCAN16 ZNF699 GPATCH8 ZNF91 ZNF782 ZNF333 ZNF714 ZNF726 GLIS1 ZNF687 ZNF639	2.96e-18	796	70	26	IPR015880
Domain	Znf_C2H2	ZNF729 ZSCAN20 ZNF354A KLF7 ZKSCAN1 GLI1 GLI3 ZNF177 GLIS2 SCAPER ADNP2 GLIS3 ZNF429 ZNF727 ZNF561 ZSCAN16 ZNF699 GPATCH8 ZNF91 ZNF782 ZNF333 ZNF714 ZNF726 GLIS1 ZNF687 ZNF639	3.90e-18	805	70	26	IPR007087
Domain	ZnF_C2H2	ZNF729 ZSCAN20 ZNF354A KLF7 ZKSCAN1 GLI1 GLI3 ZNF177 GLIS2 SCAPER ADNP2 GLIS3 ZNF429 ZNF727 ZNF561 ZSCAN16 ZNF699 GPATCH8 ZNF91 ZNF782 ZNF333 ZNF714 ZNF726 GLIS1 ZNF687 ZNF639	4.27e-18	808	70	26	SM00355
Domain	Znf_C2H2/integrase_DNA-bd	ZNF729 ZSCAN20 ZNF354A KLF7 ZKSCAN1 GLI1 GLI3 ZNF177 GLIS2 GLIS3 ZNF429 ZNF727 ZNF561 ZSCAN16 ZNF699 ZNF91 ZNF782 ZNF333 ZNF714 ZNF726 GLIS1 ZNF687 ZNF639	3.12e-16	694	70	23	IPR013087
Domain	zf-C2H2	ZNF729 ZSCAN20 ZNF354A KLF7 ZKSCAN1 GLI1 ZNF177 GLIS2 GLIS3 ZNF429 ZNF727 ZNF561 ZSCAN16 ZNF699 ZNF91 ZNF782 ZNF333 ZNF714 ZNF726 GLIS1 ZNF687 ZNF639	3.90e-15	693	70	22	PF00096
Domain	-	ZNF729 ZSCAN20 ZNF354A KLF7 ZKSCAN1 GLI1 GLI3 GLIS2 GLIS3 ZNF429 ZNF727 ZNF561 ZSCAN16 ZNF699 ZNF91 ZNF782 ZNF333 ZNF714 ZNF726 GLIS1 ZNF639	3.15e-14	679	70	21	3.30.160.60
Domain	KRAB	ZNF729 ZSCAN20 ZNF354A ZKSCAN1 ZNF177 ZNF429 ZNF727 ZNF561 ZNF699 ZNF91 ZNF782 ZNF333 ZNF714 ZNF726	7.67e-11	369	70	14	SM00349
Domain	KRAB	ZNF729 ZSCAN20 ZNF354A ZKSCAN1 ZNF177 ZNF429 ZNF727 ZNF561 ZNF699 ZNF91 ZNF782 ZNF333 ZNF714 ZNF726	7.95e-11	370	70	14	IPR001909
Domain	KRAB	ZNF729 ZNF354A ZKSCAN1 ZNF177 ZNF429 ZNF727 ZNF561 ZNF699 ZNF91 ZNF782 ZNF333 ZNF714 ZNF726	6.73e-10	358	70	13	PS50805
Domain	KRAB	ZNF729 ZNF354A ZKSCAN1 ZNF177 ZNF429 ZNF727 ZNF561 ZNF699 ZNF91 ZNF782 ZNF333 ZNF726	8.02e-09	358	70	12	PF01352
Domain	zf-C2H2_6	ZNF729 ZNF354A ZNF429 ZNF727 ZNF561 ZNF699 ZNF91 ZNF782 ZNF333 ZNF714 ZNF726	2.28e-08	314	70	11	PF13912
Domain	zf-C2H2_11	ZNF354A ZKSCAN1 ZNF687	4.17e-06	9	70	3	PF16622
Domain	Surp	SFSWAP U2SURP	2.06e-04	6	70	2	PF01805
Domain	SWAP	SFSWAP U2SURP	2.06e-04	6	70	2	SM00648
Domain	SURP	SFSWAP U2SURP	2.06e-04	6	70	2	PS50128
Domain	Surp	SFSWAP U2SURP	2.06e-04	6	70	2	IPR000061
Domain	SCAN	ZSCAN20 ZKSCAN1 ZSCAN16	1.21e-03	56	70	3	SM00431
Domain	SCAN_BOX	ZSCAN20 ZKSCAN1 ZSCAN16	1.34e-03	58	70	3	PS50804
Domain	SCAN	ZSCAN20 ZKSCAN1 ZSCAN16	1.34e-03	58	70	3	PF02023
Domain	SCAN_dom	ZSCAN20 ZKSCAN1 ZSCAN16	1.34e-03	58	70	3	IPR003309
Domain	Retrov_capsid_C	ZSCAN20 ZKSCAN1 ZSCAN16	1.41e-03	59	70	3	IPR008916
Domain	HECT	AREL1 NEDD4	4.57e-03	27	70	2	PF00632
Domain	HECTc	AREL1 NEDD4	4.57e-03	27	70	2	SM00119
Domain	HECT_dom	AREL1 NEDD4	4.57e-03	27	70	2	IPR000569
Domain	HECT	AREL1 NEDD4	4.57e-03	27	70	2	PS50237
Domain	Cyclin_N	CABLES2 CCNL1	6.78e-03	33	70	2	IPR006671
Domain	Cyclin_N	CABLES2 CCNL1	6.78e-03	33	70	2	PF00134
Domain	CYCLIN	CABLES2 CCNL1	8.92e-03	38	70	2	SM00385
Domain	-	CABLES2 CCNL1	9.85e-03	40	70	2	1.10.472.10
Pathway	REACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS	ZNF354A ZNF429 ZNF699 ZNF782 ZNF726	8.92e-07	56	45	5	MM17236
Pathway	REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION	ZNF354A ZNF429 ZNF699 ZNF782 ZNF726	6.96e-05	136	45	5	MM14848
Pathway	REACTOME_GLI_PROTEINS_BIND_PROMOTERS_OF_HH_RESPONSIVE_GENES_TO_PROMOTE_TRANSCRIPTION	GLI1 GLI3	2.07e-04	7	45	2	M27501
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF729 ZNF354A ZKSCAN1 GLI3 SOCS4 ZNF429 ZNF727 ZNF561 ZNF699 ZNF782 ZNF333 ZNF714 ZNF726	2.76e-04	1387	45	13	M734
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF729 ZNF354A ZKSCAN1 ZNF429 ZNF727 ZNF699 ZNF91 ZNF782 ZNF726	6.08e-04	768	45	9	MM14851
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY	GLI1 GLI3	8.85e-04	14	45	2	M47414
Pathway	BIOCARTA_SHH_PATHWAY	GLI1 GLI3	1.02e-03	15	45	2	MM1498
Pathway	WP_HEDGEHOG_SIGNALING_WP47	GLI1 GLI3	1.16e-03	16	45	2	M39675
Pathway	BIOCARTA_SHH_PATHWAY	GLI1 GLI3	1.16e-03	16	45	2	M11792
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF729 ZSCAN20 KLF7 ZKSCAN1 NFE2L2 GLI3 GLIS2 SCAPER GLIS3 ZNF429 ZNF91 ZNF726 GLIS1 ZNF687 ZNF639	9.22e-11	808	72	15	20412781
Pubmed	CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA.	GLI1 GLI3 GLIS2 GLIS3	3.51e-09	10	72	4	18298960
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF729 ZNF429 ZNF727 ZNF91 ZNF726	3.77e-09	29	72	5	14563677
Pubmed	GLIS3, a novel member of the GLIS subfamily of Krüppel-like zinc finger proteins with repressor and activation functions.	GLIS2 GLIS3 GLIS1	8.51e-09	3	72	3	14500813
Pubmed	Gene of the month: GLIS1-3.	GLIS2 GLIS3 GLIS1	8.51e-09	3	72	3	32699115
Pubmed	Functional analysis of the zinc finger and activation domains of Glis3 and mutant Glis3(NDH1).	GLI1 GLIS3 GLIS1	8.51e-09	3	72	3	18263616
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF729 ZNF429 ZNF91 ZNF726	2.26e-08	15	72	4	15885501
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF729 ZNF429 ZNF727 ZNF91 ZNF726	5.86e-08	49	72	5	9630514
Pubmed	RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6.	GLI1 GLI3 GLIS1	1.69e-07	6	72	3	33895473
Pubmed	A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development.	GLI1 GLI3 GLIS1	1.69e-07	6	72	3	12385751
Pubmed	Comparative analysis of KRAB zinc finger proteins in rodents and man: evidence for several evolutionarily distinct subfamilies of KRAB zinc finger genes.	ZNF429 ZNF699 ZNF726	7.08e-07	9	72	3	10360839
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF354A ZKSCAN1 ZNF561 ZNF699 ZNF91 ZNF726	2.15e-06	181	72	6	37372979
Pubmed	Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3.	GLI1 GLI3	4.23e-06	2	72	2	18559511
Pubmed	Molecular cloning and expression pattern of a Cubitus interruptus homologue from the mulberry silkworm Bombyx mori.	GLI1 GLI3	4.23e-06	2	72	2	12351188
Pubmed	A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome.	GLI1 GLI3	4.23e-06	2	72	2	21921029
Pubmed	Expression of the GLI family genes is associated with tumor progression in advanced lung adenocarcinoma.	GLI1 GLI3	4.23e-06	2	72	2	25103784
Pubmed	Palmar and plantar pads and flexion creases of genetic polydactyly mice (Pdn).	GLI1 GLI3	4.23e-06	2	72	2	9918099
Pubmed	Gli3 is a Key Factor in the Schwann Cells from Both Intact and Injured Peripheral Nerves.	GLI1 GLI3	4.23e-06	2	72	2	32114096
Pubmed	Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.	GLI1 GLI3	4.23e-06	2	72	2	10693759
Pubmed	Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions.	GLIS3 GLIS1	4.23e-06	2	72	2	12042312
Pubmed	Characterization of Glis2, a novel gene encoding a Gli-related, Krüppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis.	GLIS2 GLIS1	4.23e-06	2	72	2	11741991
Pubmed	Computational analysis and prediction of the binding motif and protein interacting partners of the Abl SH3 domain.	CABLES2 SEMA6D	4.23e-06	2	72	2	16446784
Pubmed	gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development.	GLI1 GLI3	4.23e-06	2	72	2	8364225
Pubmed	UBXN7 cofactor of CRL3KEAP1 and CRL2VHL ubiquitin ligase complexes mediates reciprocal regulation of NRF2 and HIF-1α proteins.	NFE2L2 UBXN7	1.27e-05	3	72	2	33444648
Pubmed	Hedgehog signaling indirectly affects tubular cell survival after obstructive kidney injury.	GLI1 GLIS2	1.27e-05	3	72	2	26290370
Pubmed	Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.	GLI1 GLI3	1.27e-05	3	72	2	24311597
Pubmed	Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes.	GLI1 GLI3	1.27e-05	3	72	2	26010061
Pubmed	Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3.	GLI1 GLI3	1.27e-05	3	72	2	10075717
Pubmed	Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs.	GLI1 GLIS2	1.27e-05	3	72	2	21816948
Pubmed	Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused.	GLI1 GLIS3	1.27e-05	3	72	2	21543335
Pubmed	A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.	GLI1 GLI3	1.27e-05	3	72	2	8387379
Pubmed	Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.	GLI1 GLI3	1.27e-05	3	72	2	16571352
Pubmed	The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway.	GLI1 GLI3	1.27e-05	3	72	2	29722127
Pubmed	Different expression patterns of Gli1-3 in mouse embryonic maxillofacial development.	GLI1 GLI3	1.27e-05	3	72	2	22178118
Pubmed	Brachyphalangy, an allele of extra-toes in the mouse.	GLI1 GLI3	1.27e-05	3	72	2	5806166
Pubmed	Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke.	NFE2L2 NEDD4	1.27e-05	3	72	2	36908855
Pubmed	Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.	GLI1 GLI3	1.27e-05	3	72	2	28965847
Pubmed	Gli family members are differentially expressed during the mitotic phase of spermatogenesis.	GLI1 GLI3	1.27e-05	3	72	2	9178901
Pubmed	Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.	GLI1 GLI3	1.27e-05	3	72	2	8378770
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SCAF1 ZRSR2P1 SFSWAP RBMX2 XPC PRPF38A	1.40e-05	251	72	6	31076518
Pubmed	Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis.	GLI1 GLI3 ADAMTS20	1.46e-05	23	72	3	30814516
Pubmed	Cloning and sequencing of the mouse Gli2 gene: localization to the Dominant hemimelia critical region.	GLI1 GLI3	2.53e-05	4	72	2	9027508
Pubmed	Comparative genomics identification of a novel set of temporally regulated hedgehog target genes in the retina.	GLI1 GLI3	2.53e-05	4	72	2	22281533
Pubmed	Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development.	GLI1 GLI3	2.53e-05	4	72	2	9006072
Pubmed	Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression.	GLI1 GLI3	2.53e-05	4	72	2	27793025
Pubmed	Expression profile of Gli family members and Shh in normal and mutant mouse limb development.	GLI1 GLI3	2.53e-05	4	72	2	9438426
Pubmed	Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development.	GLI1 GLI3	2.53e-05	4	72	2	8150204
Pubmed	Anorectal malformations caused by defects in sonic hedgehog signaling.	GLI1 GLI3	2.53e-05	4	72	2	11485934
Pubmed	The E3 Ubiquitin Ligase NEDD4-1 Mediates Temozolomide-Resistant Glioblastoma through PTEN Attenuation and Redox Imbalance in Nrf2-HO-1 Axis.	NFE2L2 NEDD4	2.53e-05	4	72	2	34638586
Pubmed	Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1.	GLI1 GLI3	2.53e-05	4	72	2	10531011
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AREL1 ADNP2 TANC1 MAST2	3.30e-05	87	72	4	12465718
Pubmed	Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models.	MCPH1 TEX15 STAG3	4.04e-05	32	72	3	27739607
Pubmed	SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors.	GLI1 GLI3	4.21e-05	5	72	2	20711444
Pubmed	Functional compensation in Hedgehog signaling during mouse prostate development.	GLI1 GLI3	4.21e-05	5	72	2	16707121
Pubmed	Genomic organization, chromosomal assignment, and expression analysis of the mouse suppressor of fused gene (Sufu) coding a Gli protein partner.	GLI1 GLI3	4.21e-05	5	72	2	10920228
Pubmed	A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro.	GLI1 GLI3	4.21e-05	5	72	2	9118802
Pubmed	Evidence for the involvement of the Gli gene family in embryonic mouse lung development.	GLI1 GLI3	4.21e-05	5	72	2	9268579
Pubmed	Sonic hedgehog signals to multiple prostate stromal stem cells that replenish distinct stromal subtypes during regeneration.	GLI1 GLI3	4.21e-05	5	72	2	24218555
Pubmed	Gli regulation by the opposing activities of fused and suppressor of fused.	GLI1 GLI3	4.21e-05	5	72	2	10806483
Pubmed	p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9.	GLI1 GLI3	4.21e-05	5	72	2	26282181
Pubmed	Gli1 is a target of Sonic hedgehog that induces ventral neural tube development.	GLI1 GLI3	4.21e-05	5	72	2	9216996
Pubmed	The KRAB zinc finger protein RSL1 modulates sex-biased gene expression in liver and adipose tissue to maintain metabolic homeostasis.	ZNF429 ZNF726	4.21e-05	5	72	2	24190968
Pubmed	Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain.	GLI1 GLI3	4.21e-05	5	72	2	15614767
Pubmed	Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3.	GLI1 GLI3	4.21e-05	5	72	2	19996099
Pubmed	Expression of sonic hedgehog, patched, and Gli1 in developing taste papillae of the mouse.	GLI1 GLI3	4.21e-05	5	72	2	10096602
Pubmed	Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation.	GLI1 GLI3	4.21e-05	5	72	2	16611981
Pubmed	Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning.	GLI1 GLI3	4.21e-05	5	72	2	15315762
Pubmed	A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud.	GLI1 GLI3	4.21e-05	5	72	2	24700818
Pubmed	A pair of mouse KRAB zinc finger proteins modulates multiple indicators of female reproduction.	ZNF429 ZNF726	4.21e-05	5	72	2	20042539
Pubmed	Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli.	GLI1 GLI3	4.21e-05	5	72	2	10564661
Pubmed	Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma.	GLI1 GLI3	4.21e-05	5	72	2	19593328
Pubmed	Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling.	GLI1 GLI3	4.21e-05	5	72	2	26120032
Pubmed	Expression pattern of Irx1 and Irx2 during mouse digit development.	GLI1 GLI3	4.21e-05	5	72	2	11472848
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	PTPRF TENT4A U2SURP BTBD10 GPATCH8 NEDD4	4.80e-05	313	72	6	38270169
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SCAF1 SFSWAP ZKSCAN1 BMP2K RBMX2 CCNL1 ANKRD11 TANC1 XPC PRPF38A GPATCH8 ZNF687	5.43e-05	1497	72	12	31527615
Pubmed	Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells.	GLI1 GLI3	6.31e-05	6	72	2	21549329
Pubmed	Pleiotropy in FOXC1-attributable phenotypes involves altered ciliation and cilia-dependent signaling.	GLI1 GLI3	6.31e-05	6	72	2	39217245
Pubmed	Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.	GLI1 GLI3	6.31e-05	6	72	2	14681189
Pubmed	The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons.	ZNF429 ZNF726	6.31e-05	6	72	2	30846446
Pubmed	Targeted disruption of Sonic Hedgehog in the mouse adrenal leads to adrenocortical hypoplasia.	GLI1 GLI3	6.31e-05	6	72	2	19536807
Pubmed	Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling.	GLI1 GLI3	6.31e-05	6	72	2	31279575
Pubmed	Physical and functional interactions between Zic and Gli proteins.	GLI1 GLI3	6.31e-05	6	72	2	11238441
Pubmed	Expression of sonic hedgehog signaling molecules in normal, hyperplastic and carcinomatous endometrium.	GLI1 GLI3	6.31e-05	6	72	2	19432668
Pubmed	Titration of GLI3 repressor activity by sonic hedgehog signaling is critical for maintaining multiple adult neural stem cell and astrocyte functions.	GLI1 GLI3	6.31e-05	6	72	2	24174682
Pubmed	Loss of Sprouty Produces a Ciliopathic Skeletal Phenotype in Mice Through Upregulation of Hedgehog Signaling.	GLI1 GLI3	6.31e-05	6	72	2	34423857
Pubmed	The Pluripotency Factor NANOG Binds to GLI Proteins and Represses Hedgehog-mediated Transcription.	GLI1 GLI3	6.31e-05	6	72	2	26797124
Pubmed	Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling.	GLI1 GLI3	6.31e-05	6	72	2	17202190
Pubmed	Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.	GLI1 GLI3	6.31e-05	6	72	2	16254602
Pubmed	Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium.	GLI1 GLI3	6.31e-05	6	72	2	21209912
Pubmed	Genetic analysis of Hedgehog signaling in ventral body wall development and the onset of omphalocele formation.	GLI1 GLI3	6.31e-05	6	72	2	21283718
Pubmed	Irx1 and Irx2 expression in early lung development.	GLI1 GLI3	6.31e-05	6	72	2	11472847
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SCAF1 SFSWAP MCPH1 NFE2L2 RBMX2 U2SURP ANKRD11 XPC PRPF38A GPATCH8 ZNF687	6.83e-05	1294	72	11	30804502
Pubmed	Tagging genes with cassette-exchange sites.	SFSWAP SOCS4 ZNF429 TANC1 GPATCH8 ZNF726	6.99e-05	335	72	6	15741177
Pubmed	The KRAB zinc finger protein RSL1 regulates sex- and tissue-specific promoter methylation and dynamic hormone-responsive chromatin configuration.	ZNF429 ZNF726	8.82e-05	7	72	2	22801370
Pubmed	Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice.	GLI1 GLI3	8.82e-05	7	72	2	9152005
Pubmed	A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus.	GLI1 GLI3	8.82e-05	7	72	2	21653639
Pubmed	Analysis of the Sonic Hedgehog signaling pathway in normal and abnormal bladder development.	GLI1 GLI3	8.82e-05	7	72	2	23308271
Pubmed	Sonic hedgehog regulates discrete populations of astrocytes in the adult mouse forebrain.	GLI1 GLI3	8.82e-05	7	72	2	20943901
Pubmed	Hedgehog regulates Norrie disease protein to drive neural progenitor self-renewal.	GLI1 GLI3	8.82e-05	7	72	2	23201751
Pubmed	FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine.	GLI1 GLI3	8.82e-05	7	72	2	19049965
Interaction	JMJD6 interactions	SCAF1 ZRSR2P1 SFSWAP RBMX2 U2SURP CCNL1 PRPF38A	6.43e-06	205	69	7	int:JMJD6
Interaction	SRRM4 interactions	ZRSR2P1 RBMX2 PRPF38A ZNF699	7.63e-06	37	69	4	int:SRRM4
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF729 ZNF429 ZNF91 ZNF714 ZNF726	1.48e-06	122	72	5	chr19p12
Cytoband	19p12	ZNF729 ZNF91 ZNF714 ZNF726	1.28e-05	90	72	4	19p12
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF729 ZSCAN20 ZNF354A KLF7 ZKSCAN1 GLI1 GLI3 ZNF177 GLIS2 SCAPER ADNP2 GLIS3 ZNF429 ZNF727 ZNF561 ZSCAN16 ZNF699 ZNF91 ZNF782 ZNF333 ZNF714 ZNF726 GLIS1 ZNF639	2.43e-20	718	52	24	28
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_k-means-cluster#4_top-relative-expression-ranked_1000	BTBD10 SCAPER TEX15 GPATCH8 STAG3	3.15e-05	110	70	5	gudmap_dev gonad_e13.5_M_GermCell_Oct_k4_1000
CoexpressionAtlas	dev gonad_e12.5_F_GermCellOvary_Oct_k-means-cluster#2_top-relative-expression-ranked_1000	RBMX2 BTBD10 SCAPER TEX15 STAG3	3.90e-05	115	70	5	gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_k2_1000
CoexpressionAtlas	DevelopingGonad_e18.5_testes_emap-11164_k-means-cluster#4_top-relative-expression-ranked_500	NEXMIF TEX15 STAG3	5.80e-05	23	70	3	gudmap_developingGonad_e18.5_testes_500_k4
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_500	BTBD10 SCAPER TEX15 STAG3	7.96e-05	69	70	4	gudmap_dev gonad_e13.5_M_GermCell_Oct_k1_500
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_k-means-cluster#4_top-relative-expression-ranked_1000	BTBD10 SCAPER TEX15 STAG3	9.41e-05	72	70	4	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_k4_1000
CoexpressionAtlas	dev gonad_e12.5_M_InterstitTestis_Sma_k-means-cluster#2_top-relative-expression-ranked_200	STOX2 GLI1 SMOC2	9.48e-05	27	70	3	gudmap_dev gonad_e12.5_M_InterstitTestis_Sma_k2_200
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZKSCAN1 BMP2K NFE2L2 VPS13C ANKRD11 NEDD4	6.70e-07	191	72	6	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZKSCAN1 BMP2K NFE2L2 VPS13C ANKRD11 NEDD4	6.70e-07	191	72	6	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZKSCAN1 BMP2K NFE2L2 VPS13C ANKRD11 NEDD4	6.70e-07	191	72	6	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	NFE2L2 VPS13C CCNL1 ANKRD11 CIR1	1.69e-05	197	72	5	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	STOX2 SCAPER KIAA1328 GLIS3 TANC1	1.73e-05	198	72	5	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	NFE2L2 VPS13C CCNL1 ANKRD11 CIR1	1.73e-05	198	72	5	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NFE2L2 VPS13C CCNL1 ANKRD11 CIR1	1.73e-05	198	72	5	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	Bronchial-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CLEC3A ZKSCAN1 CMYA5 GLIS1 NEDD4	1.81e-05	200	72	5	b7b9441fa7ab0d43741a2ebd5ec1a48d537c6d47
ToppCell	Bronchial-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CLEC3A ZKSCAN1 CMYA5 GLIS1 NEDD4	1.81e-05	200	72	5	7c673ad0ea503ebd196579684d25d5f9e6a41030
Drug	vinylene	ZNF354A KLF7 GLI1 ZNF177 GLIS2 ZNF91 ZNF333 GLIS1	1.06e-06	245	72	8	CID000006326
Disease	central corneal thickness	CFAP95 GLI3 GLIS2 GLIS3 ADAMTS20 SMOC2	9.38e-05	309	70	6	EFO_0005213
Disease	corneal resistance factor	CFAP95 GLI3 GLIS2 GLIS3 ADAMTS20 SMOC2 NEDD4	9.73e-05	451	70	7	EFO_0010067
Disease	Gastrointestinal Stromal Sarcoma	GLI1 GLI3 GLIS2	1.92e-04	47	70	3	C3179349
Disease	primary bacterial infectious disease (implicated_via_orthology)	GLI1 GLI3	1.98e-04	9	70	2	DOID:0050338 (implicated_via_orthology)
Disease	Gastrointestinal Stromal Tumors	GLI1 GLI3 GLIS2	2.31e-04	50	70	3	C0238198
Disease	kynurenic acid measurement	SEMA6D ZNF177	4.25e-04	13	70	2	EFO_0010506
Disease	digit length ratio	GLI3 GLIS1	6.52e-04	16	70	2	EFO_0004841
Disease	pre-malignant neoplasm (biomarker_via_orthology)	GLI1 GLI3	7.37e-04	17	70	2	DOID:0060071 (biomarker_via_orthology)
Disease	diet measurement	SEMA6D PTPRF NGEF KIAA1328 GLIS3 POM121L2 TEX15 GPATCH8 ZNF714	8.14e-04	1049	70	9	EFO_0008111
Disease	attention deficit hyperactivity disorder, Cannabis use	SEMA6D PTPRF	8.28e-04	18	70	2	EFO_0003888, EFO_0007585
Disease	Abnormality of refraction	PTPRF ZKSCAN1 GLI3 GLIS3 ADAMTS20 GLIS1 NEDD4	1.08e-03	673	70	7	HP_0000539
Disease	Ovarian Failure, Premature	NFE2L2 STAG3	1.13e-03	21	70	2	C0085215
Disease	intraocular pressure measurement	CFAP95 STOX2 MCPH1 GLIS3 ADAMTS20 NEDD4	1.32e-03	509	70	6	EFO_0004695
Disease	PCSK9 protein measurement	ATXN7L1 KIAA1328	1.74e-03	26	70	2	EFO_0006899
Disease	Micronuclei, Chromosome-Defective	NFE2L2 XPC	1.74e-03	26	70	2	C1449861
Disease	Micronuclei, Genotoxicant-Induced	NFE2L2 XPC	1.74e-03	26	70	2	C1449862
Disease	azoospermia (implicated_via_orthology)	PTPRF SCAPER	1.87e-03	27	70	2	DOID:14227 (implicated_via_orthology)
Disease	type 2 diabetes mellitus (implicated_via_orthology)	GLIS3 ADAMTS20 GLIS1	2.02e-03	105	70	3	DOID:9352 (implicated_via_orthology)
Disease	platelet component distribution width	KLF7 TENT4A BMP2K U2SURP SMOC2 ZNF333 SPIN3	2.07e-03	755	70	7	EFO_0007984

Protein segments in the cluster

Peptide	Gene	Start	Entry
KKFSRHHGPTITAKL	AMBP	136	P02760
KLHSRPRKLYKHSST	BTBD10	21	Q9BSF8
PEKLKEKERHRHSSS	ANKRD11	1341	Q6UB99
PHLKAKHTRDDLKSS	CCNL1	446	Q9UK58
RHHGTPTSTKKTLKP	BMP2K	996	Q9NSY1
THSLSHRRAVPGRKK	ATXN7L1	316	Q9ULK2
TEIPSTKKHKLHRLR	ADAMTS20	1616	P59510
SEHSRNRHLGKKKLP	ADNP2	786	Q6IQ32
TKAGPRKGHSRHKST	RAB3IL1	181	Q8TBN0
KPKHEHKSSSRREAR	RBMX2	246	Q9Y388
GSLTLRSHHKKYSKP	CFAP95	31	Q5VTT2
KRYTDPSSLRKHVKT	GLI3	616	P10071
RKRVSHGSHSPPKEK	MCPH1	356	Q8NEM0
RSHVTHRTTKVKKSP	LRRC37A	1311	A6NMS7
KDFVLHPRSHKSRVK	NEDD4	546	P46934
SLPSKKERSGKSHRH	GPATCH8	661	Q9UKJ3
HRKTPFTKDKHSSRL	NFE2L2	436	Q16236
VKRSHHELSSEPKRS	FAM205A	31	Q6ZU69
KRYTDPSSLRKHVKT	GLI1	371	P08151
LTRHYRKHTGAKPFK	KLF7	266	O75840
HKRYTDPSSLRKHIK	GLIS2	301	Q9BZE0
HGTFRLSPLKSTRKK	KIAA1328	541	Q86T90
RKKHTHTRDSLPVSL	TENT4A	756	Q5XG87
RSLHDSHKASKTPLK	NOTUM	416	Q6P988
KHLKRSRDSSPLKDS	POLQ	1046	O75417
VRKRTHKSKHGSPSL	CMYA5	131	Q8N3K9
PSSLRKHVKAHSSKE	GLIS3	486	Q8NEA6
KRPHSKVTLKVSRHA	AREL1	456	O15033
KLATSRKHSLDLPHS	MAST2	1421	Q6P0Q8
PSSLRKHVKAHSAKE	GLIS1	336	Q8NBF1
KHFDKSPTKTRHPRK	SCAPER	81	Q9BY12
TKHTSGSPRHKGLKK	CABLES2	146	Q9BTV7
ILLFKRKRTHSPSSK	PTPRF	1281	P10586
HKKRSRTRSRSPKYH	SFSWAP	761	Q12872
PLSDSIHKKKHTRPT	NKX6-3	131	A6NJ46
SLLESHSSKLDPHKR	RHBDL3	61	P58872
GPTHKKLYRHKSSSK	NEXMIF	1441	Q5QGS0
GPKTSRTLRTKKLFH	NGEF	501	Q8N5V2
RHSSGLPSKRKIHIS	SOCS4	111	Q8WXH5
EAHRSHLTAAKPKRS	TANC1	1841	Q9C0D5
SKTPKNREKGHSRRH	POM121L2	1016	Q96KW2
RSQSRSPHRSHKKSK	U2SURP	1011	O15042
DKKSRTHKHSPEKRG	CIR1	356	Q86X95
TSHTSRLKARKHSKR	CLEC3A	21	O75596
SRRSKHLKTHSGEKP	ZNF561	406	Q8N587
SLIKHKRSHTGDRPT	ZNF727	466	A8MUV8
SNRHKTRHTGEKPFK	ZNF714	131	Q96N38
KKRKRKTLHPSRYSD	ZNF639	6	Q9UID6
SSLKKHTRSHTGEKP	ZNF177	381	Q13360
KNLLRSYRKAKSSHP	ZSCAN20	541	P17040
KHPKKGSRVVHRHSR	STAG3	76	Q9UJ98
DSKKHRSRDRKPGSH	SCAF1	551	Q9H7N4
KADTKKRHTPRGHAE	SMOC2	421	Q9H3U7
RSKKSRTHRKSHGKS	STOX2	356	Q9P2F5
KAAHKKHRSRPTSQP	SPIN3	31	Q5JUX0
KAAGHRSHKRKLSGP	nan	241	A8MX80
GSKRKPLHLISSSDK	VPS13C	971	Q709C8
RSHSKSPERSKKSHK	PRPF38A	291	Q8NAV1
PLLKKYRHHKKATRT	nan	11	Q1RN00
SSLKTHLRTHTREKP	ZNF333	491	Q96JL9
SLRKHARTHSGKKPY	ZNF333	576	Q96JL9
STLTRHKRLHSGEKP	ZNF726	326	A6NNF4
SLTKHKRIHTREKPF	ZNF91	756	Q05481
STLTRHKRLHTGEKP	ZNF91	1091	Q05481
LSKHRRTHTGEKPYK	ZSCAN16	251	Q9H4T2
RAASHSSHKRKLSEP	nan	241	A8MUI8
SRLTQHKKIHTREKP	ZNF429	606	Q86V71
KSRKSPHKDLGHRKE	UBXN7	346	O94888
SPGSLSRHRFISHKK	ZNF687	1146	Q8N1G0
SHRGKKSHKRTSKSR	ZRSR2P1	406	Q15695
KLKSGLRKHHRTHTG	ZNF782	516	Q6ZMW2
SATHKKIPTIERSHK	ZNF354A	146	O60765
TQSHFKHSSRKPRLL	ZKSCAN1	176	P17029
KATFKHPRTTGSHPK	TEX15	2351	Q9BXT5
KSASRTHRGSHRKDP	XPC	481	Q01831
SLSKHKRIHSGDKPY	ZNF699	321	Q32M78
IDHPLTKSSSKRDHR	SEMA6D	856	Q8NFY4
SDLRRHKIIHTGKKP	ZNF729	501	A6NN14