Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	AMPA glutamate receptor complex	CACNG3 OLFM2	4.94e-04	30	23	2	GO:0032281
GeneOntologyCellularComponent	ionotropic glutamate receptor complex	CACNG3 OLFM2	1.11e-03	45	23	2	GO:0008328
GeneOntologyCellularComponent	nuclear speck	TOPORS RBM27 RBM15 INPPL1	1.16e-03	431	23	4	GO:0016607
GeneOntologyCellularComponent	neurotransmitter receptor complex	CACNG3 OLFM2	1.37e-03	50	23	2	GO:0098878
GeneOntologyCellularComponent	asymmetric synapse	CACNG3 PLXNA4 SPOCK1 OLFM2	1.68e-03	477	23	4	GO:0032279
GeneOntologyCellularComponent	neuron to neuron synapse	CACNG3 PLXNA4 SPOCK1 OLFM2	2.35e-03	523	23	4	GO:0098984
GeneOntologyCellularComponent	nuclear body	TOPORS RBM27 SUDS3 RBM15 INPPL1	2.61e-03	903	23	5	GO:0016604
Domain	CHROMO	SMARCC2 CHD1	6.84e-04	33	22	2	SM00298
Domain	Chromo/shadow_dom	SMARCC2 CHD1	6.84e-04	33	22	2	IPR000953
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	RBM27 SMARCC2 SUDS3 PAXBP1	2.72e-05	268	23	4	33640491
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	RBM27 SMARCC2 SUDS3 RBM15 CHD1 CDC23	3.99e-05	1014	23	6	32416067
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SLC16A1 SPOCK1 RBM27 SMARCC2 RBM15 PAXBP1	5.73e-05	1082	23	6	38697112
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	CFLAR INPPL1 MMP1 HAPLN1	7.76e-05	351	23	4	20453000
Pubmed	TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins.	TOPORS SMARCC2	9.59e-05	22	23	2	17803295
Pubmed	High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes.	CACNG3 OLFM2	1.14e-04	24	23	2	22632720
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TOPORS SMARCC2 RBM15 PAXBP1 CDC23	1.30e-04	774	23	5	15302935
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	TOPORS SMARCC2 RBM15 CHD1	1.42e-04	411	23	4	35182466
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	SLC16A1 SUDS3 RBM15 CHD1 INPPL1 SSH2	1.76e-04	1327	23	6	32694731
Pubmed	Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.	CHD1 INPPL1	1.80e-04	30	23	2	12522270
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	RBM27 SMARCC2 RBM15 CHD1 PAXBP1	1.98e-04	847	23	5	35850772
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	SLC16A1 RBM27 RBM15	2.31e-04	182	23	3	32239614
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	SLC16A1 SMARCC2 RBM15 CHD1 INPPL1	2.84e-04	916	23	5	32203420
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	RBM27 SMARCC2 RBM15 CHD1 PAXBP1	3.43e-04	954	23	5	36373674
Pubmed	ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.	SMARCC2 SUDS3	3.54e-04	42	23	2	16387653
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	SLC16A1 RBM27 SMARCC2 RBM15 CHD1	4.04e-04	989	23	5	36424410
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	TOPORS RBM15 INPPL1 CDC23	5.55e-04	588	23	4	38580884
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	SMARCC2 CDC23 SSH2	5.58e-04	246	23	3	15345747
Interaction	MMP3 interactions	SPOCK1 MMP1 HAPLN1	1.01e-05	39	22	3	int:MMP3
Interaction	PLIN5 interactions	CFLAR INPPL1	5.09e-05	10	22	2	int:PLIN5
Cytoband	Ensembl 112 genes in cytogenetic band chr1p13	SLC16A1 RBM15	4.99e-03	211	23	2	chr1p13
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	SPOCK1 CDC23	9.71e-03	298	23	2	chr5q31
Disease	tendinitis (biomarker_via_orthology)	LRP5 MMP1	7.22e-06	6	21	2	DOID:971 (biomarker_via_orthology)
Disease	idiopathic pulmonary fibrosis (is_marker_for)	CFLAR MMP1	1.21e-04	23	21	2	DOID:0050156 (is_marker_for)
Disease	Colorectal Neoplasms	CHD1 MMP1 HAPLN1	9.60e-04	277	21	3	C0009404
Disease	Colorectal Carcinoma	CHD1 OLFM2 MMP1 HAPLN1	1.38e-03	702	21	4	C0009402
Disease	peptide measurement	RBM27 SUDS3	2.71e-03	109	21	2	EFO_0010520

Protein segments in the cluster

Peptide	Gene	Start	Entry
KRDYRAWYGLGQTYE	CDC23	396	Q9UJX2
ADNIRKYWSRYYQGS	ARL15	86	Q9NXU5
QRDSKKSYSYGWSFY	CACNG3	166	O60359
RDWDHYKQDSRYYSD	CHD1	1586	O14646
YDWNSRVSAKEKYYV	CFLAR	451	O15519
YRKGDSWAYIQYESL	RBM15	486	Q96T37
KKREDGKWRDYDRYY	RBM27	136	Q9P2N5
GKWRDYDRYYERNEL	RBM27	141	Q9P2N5
ADSRVWYMDGYYKGR	OLFM2	226	O95897
RLNDMYGDYKYTYWA	SLC16A1	411	P53985
DYSASRWKASKYYLD	LRP5	1551	O75197
SYKNWVERYYSDIGK	PLXNA4	1806	Q9HCM2
QFEAWRSKYYTSYKD	PAXBP1	601	Q9Y5B6
GRTYYRSKWYNDYAV	IGHV6-1	71	A0A0B4J1U7
YLYRVTGDRKYQDWG	MAN1B1	606	Q9UKM7
YEREASKYWDTFYKI	METTL8	81	Q9H825
RNYGFWDKDKSRYDV	HAPLN1	236	P10915
FFVANKYWRYDEYKR	MMP1	391	P03956
YRYERGSRDTYAWHK	INPPL1	661	O15357
AAYKFKSDQGWRRYD	SMARCC2	96	Q8TAQ2
YGWNLDRAYDYVKER	SSH2	411	Q76I76
YDRDKYWNRFRDDDY	SPOCK1	51	Q08629
KWEYTYYSRNKDRDG	TOPORS	701	Q9NS56
RIEDGKLYYDKRWYH	SUDS3	256	Q9H7L9