Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	lipoprotein particle receptor binding	LRP1 SACS	1.56e-03	39	30	2	GO:0070325
GeneOntologyMolecularFunction	disordered domain specific binding	MYO5A FYN	1.56e-03	39	30	2	GO:0097718
GeneOntologyBiologicalProcess	positive regulation of protein localization to membrane	LRP1 MYO5A FYN EPHA2	3.64e-05	130	30	4	GO:1905477
GeneOntologyCellularComponent	insulin-responsive compartment	LRP1 MYO5A	1.09e-04	11	30	2	GO:0032593
Domain	TMEM9	TMEM9B TMEM9	2.49e-06	2	30	2	IPR008853
Domain	Tmemb_9	TMEM9B TMEM9	2.49e-06	2	30	2	PF05434
Domain	Growth_fac_rcpt_	LRP1 EGF EPHA2 LAMA1	1.08e-04	156	30	4	IPR009030
Domain	Ldl_recept_b	LRP1 EGF	2.24e-04	14	30	2	PF00058
Domain	LDLRB	LRP1 EGF	2.24e-04	14	30	2	PS51120
Domain	LY	LRP1 EGF	2.59e-04	15	30	2	SM00135
Domain	LDLR_classB_rpt	LRP1 EGF	2.59e-04	15	30	2	IPR000033
Domain	EGF-like_CS	LRP1 EGF EPHA2 LAMA1	7.67e-04	261	30	4	IPR013032
Domain	EGF_2	LRP1 EGF EPHA2 LAMA1	8.12e-04	265	30	4	PS01186
Domain	Ser-Thr/Tyr_kinase_cat_dom	NEK6 FYN EPHA2	1.38e-03	138	30	3	IPR001245
Domain	-	LRP1 EGF	1.78e-03	39	30	2	2.120.10.30
Domain	6-blade_b-propeller_TolB-like	LRP1 EGF	2.47e-03	46	30	2	IPR011042
Domain	Sushi	CSMD3 CFHR3	3.15e-03	52	30	2	PF00084
Domain	CCP	CSMD3 CFHR3	3.39e-03	54	30	2	SM00032
Domain	SUSHI	CSMD3 CFHR3	3.64e-03	56	30	2	PS50923
Domain	Sushi_SCR_CCP_dom	CSMD3 CFHR3	3.77e-03	57	30	2	IPR000436
Domain	EGF	LRP1 EGF LAMA1	6.21e-03	235	30	3	SM00181
Domain	EGF-like_dom	LRP1 EGF LAMA1	7.29e-03	249	30	3	IPR000742
Domain	EGF_1	LRP1 EGF LAMA1	7.78e-03	255	30	3	PS00022
Domain	EGF_CA	LRP1 EGF	8.38e-03	86	30	2	PF07645
Domain	TyrKc	FYN EPHA2	8.76e-03	88	30	2	SM00219
Domain	Tyr_kinase_cat_dom	FYN EPHA2	8.76e-03	88	30	2	IPR020635
Domain	Galactose-bd-like	EPHA2 LAMA1	9.95e-03	94	30	2	IPR008979
Domain	PROTEIN_KINASE_TYR	FYN EPHA2	1.06e-02	97	30	2	PS00109
Domain	EGF_Ca-bd_CS	LRP1 EGF	1.06e-02	97	30	2	IPR018097
Domain	Tyr_kinase_AS	FYN EPHA2	1.06e-02	97	30	2	IPR008266
Domain	EGF_CA	LRP1 EGF	1.10e-02	99	30	2	PS01187
Domain	ASX_HYDROXYL	LRP1 EGF	1.12e-02	100	30	2	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	LRP1 EGF	1.25e-02	106	30	2	IPR000152
Pubmed	The lysosomal transmembrane protein 9B regulates the activity of inflammatory signaling pathways.	TMEM9B TMEM9	7.19e-07	2	30	2	18541524
Pubmed	A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion.	LRP1 EPHA2	2.16e-06	3	30	2	21408136
Pubmed	Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1.	LRP1 FYN	7.18e-06	5	30	2	23386614
Pubmed	Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor.	EGF FYN	1.08e-05	6	30	2	20606012
Pubmed	Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529.	EGF FYN	1.08e-05	6	30	2	18156174
Pubmed	Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor.	EGF FYN	1.51e-05	7	30	2	11994282
Pubmed	Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor.	EPHA2 LAMA1	2.01e-05	8	30	2	8405064
Pubmed	BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling.	ATG4B FYN	2.58e-05	9	30	2	23555801
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	LRP1 NFXL1 MUC6	3.18e-05	71	30	3	33541421
Pubmed	Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.	LRP1 SACS	6.50e-05	14	30	2	15082773
Pubmed	The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.	FYN LAMA1	6.50e-05	14	30	2	9151674
Pubmed	Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.	LTBR NEK6 TMEM9B	7.36e-05	94	30	3	12761501
Pubmed	Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.	CSMD3 LAMA1	1.64e-04	22	30	2	35245678
Pubmed	Genome-wide association study of proneness to anger.	FYN POLR1H	1.96e-04	24	30	2	24489884
Pubmed	Functional analysis of secreted and transmembrane proteins critical to mouse development.	EPHA2 LAMA1	3.29e-04	31	30	2	11431694
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	LRP1 LTBR TMEM9 ATP2A3 EPHA2 LAMA1	4.88e-04	1201	30	6	35696571
Interaction	CLCN4 interactions	MTAP TMEM9B TMEM9	1.04e-07	7	30	3	int:CLCN4
Interaction	FZD7 interactions	NFXL1 TMEM9B TMEM9 ATP2A3	5.01e-06	77	30	4	int:FZD7
Interaction	CLCN5 interactions	MTAP TMEM9B TMEM9	6.70e-06	25	30	3	int:CLCN5
Interaction	LRRIQ1 interactions	MYO5A FYN EPHA2	3.53e-05	43	30	3	int:LRRIQ1
Interaction	CLCN3 interactions	MTAP TMEM9B TMEM9	5.91e-05	51	30	3	int:CLCN3
Cytoband	19q13.43	ZNF814 ZNF552	1.49e-03	87	30	2	19q13.43
Cytoband	17p13.3	ATP2A3 DOC2B	1.53e-03	88	30	2	17p13.3
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CSMD3 CFHR3	1.79e-03	57	20	2	1179
Computational	Immune response.	LRP1 LTBR EGF FYN EPHA2	1.03e-04	398	14	5	MODULE_75
Disease	pancreatic cancer (is_marker_for)	MTAP EGF MUC6	1.20e-04	101	28	3	DOID:1793 (is_marker_for)
Disease	upper respiratory tract disorder	LTBR NEK6	3.23e-04	28	28	2	MONDO_0004867
Disease	glutamate measurement	DGLUCY UNC5D	3.47e-04	29	28	2	EFO_0010487
Disease	Squamous cell carcinoma of lung	FYN EPHA2	4.23e-04	32	28	2	C0149782
Disease	lung adenocarcinoma	MTAP FYN POLR1H	5.92e-04	174	28	3	EFO_0000571
Disease	Liver Cirrhosis, Experimental	FTCD EGF NEK6 MYO5A FYN	7.30e-04	774	28	5	C0023893
Disease	spleen volume	LTBR EGF	7.65e-04	43	28	2	EFO_0600047
Disease	disorder of pharynx	LTBR NEK6	8.76e-04	46	28	2	MONDO_0020592
Disease	lung carcinoma	MTAP FYN POLR1H LAMA1	1.05e-03	482	28	4	EFO_0001071
Disease	susceptibility to common cold measurement	DGLUCY MYO5A	1.21e-03	54	28	2	EFO_0008417
Disease	adverse effect, response to xenobiotic stimulus	MTAP LAMA1	1.44e-03	59	28	2	EFO_0009658, GO_0009410
Disease	cardiomyopathy (implicated_via_orthology)	LRP1 DOC2B	2.07e-03	71	28	2	DOID:0050700 (implicated_via_orthology)
Disease	non-small cell lung carcinoma	MTAP LAMA1	2.31e-03	75	28	2	EFO_0003060
Disease	Hereditary Diffuse Gastric Cancer	FYN MUC6 POLR1H	2.64e-03	293	28	3	C1708349
Disease	Stomach Neoplasms	FYN MUC6 POLR1H	2.74e-03	297	28	3	C0038356
Disease	Alveolitis, Fibrosing	EGF FYN	2.82e-03	83	28	2	C4721507
Disease	Malignant neoplasm of stomach	FYN MUC6 POLR1H	2.82e-03	300	28	3	C0024623
Disease	Pulmonary Fibrosis	EGF FYN	2.95e-03	85	28	2	C0034069
Disease	Colorectal Carcinoma	LRP1 CSMD3 SACS LAMA1	4.13e-03	702	28	4	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
PMRDVGEDQVHPPLC	AHRR	471	A9YTQ3
PLPECIMIDCGHPGV	CSMD3	2986	Q7Z407
CVGMLDPPRPEVAAC	ATP2A3	596	Q93084
CQHPPCRMSIAELDP	ATG4B	301	Q9Y4P1
CHIPMAEPFCPKTRE	MTAP	136	Q13126
FDHEEGVCVPCMPPT	MUC6	1186	Q6W4X9
MAEECPRACAEPVAP	PIERCE1	1	Q5BN46
EMTVPQKPSVCHRPC	HDX	206	Q7Z353
CHPGECPPCVQMLRI	NFXL1	721	Q6ZNB6
ECQCPPHMTGPRCEE	LRP1	4396	Q07954
LVSMCICPDPHQRPD	NEK6	281	Q9HC98
PPRCIHPCIITEENM	CFHR3	261	Q02985
EHMAIDVCPGPIRPI	DOC2B	16	Q14184
IDECEMGVPVCPPAS	EGF	871	P01133
VPPGGEEPRMHCAVD	EPHA2	236	P29317
PCPQDCPISLHELMI	FYN	486	P06241
AGFCCPLVVTMRPIP	DGLUCY	156	Q7Z3D6
CAPPDMCDVGHAILI	SACS	1181	Q9NZJ4
EHPRMGALDVCPFIP	FTCD	81	O95954
PEMFCKLVEHVPGRP	LAMA1	46	P25391
PVVDRRCPRCGHEGM	POLR1H	81	Q9P1U0
KDCNCLHVVEPMPVP	TMEM9	51	Q9P0T7
CDCLHVVEPMPVRGP	TMEM9B	66	Q9NQ34
PIEGMIVLHCRPPEG	UNC5D	171	Q6UXZ4
CRPCDPVMGLEEIAP	LTBR	101	P36941
AHPCEMCGPILGDIL	ZNF587B	91	E7ETH6
HPCEMCGPILGDILH	ZNF552	91	Q9H707
AHPCEMCGPILGDIL	ZNF814	91	B7Z6K7
PMDHCLLCVCVVPLP	WDR64	206	B1ANS9
PPKHEPLCIFCELMG	MYO5A	351	Q9Y4I1