Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentsecretory granule lumen

ILF2 ARSA FN1

1.47e-03325153GO:0034774
GeneOntologyCellularComponentcytoplasmic vesicle lumen

ILF2 ARSA FN1

1.54e-03330153GO:0060205
GeneOntologyCellularComponentvesicle lumen

ILF2 ARSA FN1

1.57e-03332153GO:0031983
GeneOntologyCellularComponentbasement membrane

LAMA5 FN1

3.38e-03122152GO:0005604
HumanPhenoPeriauricular skin tag

ALX3 TMEM260 FN1

7.49e-058163HP:0100278
HumanPhenoPreauricular skin tag

ALX3 TMEM260 FN1

7.49e-058163HP:0000384
HumanPhenoShort lower limbs

LAMA5 FN1

8.97e-051362HP:0006385
HumanPhenoSkin tags

ALX3 TMEM260 FN1

1.28e-049763HP:0010609
HumanPhenoAbnormal periauricular region morphology

ALX3 TMEM260 FN1

3.14e-0413163HP:0000383
DomainTBC

TBC1D19 TBC1D22A

6.93e-0449152SM00164
DomainRabGAP-TBC

TBC1D19 TBC1D22A

8.10e-0453152PF00566
DomainTBC_RABGAP

TBC1D19 TBC1D22A

8.72e-0455152PS50086
DomainRab-GTPase-TBC_dom

TBC1D19 TBC1D22A

8.72e-0455152IPR000195
DomainEGF_1

LAMA5 FN1

1.73e-02255152PS00022
DomainEGF-like_CS

LAMA5 FN1

1.81e-02261152IPR013032
PathwayWP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION

CDH16 FN1

7.70e-0519102M39370
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

LAMA5 CAPN10 FN1

1.09e-04140103M587
PathwayREACTOME_MET_ACTIVATES_PTK2_SIGNALING

LAMA5 FN1

1.95e-0430102M27772
PathwayWP_INFLAMMATORY_RESPONSE_PATHWAY

LAMA5 FN1

1.95e-0430102MM15812
PathwayWP_INFLAMMATORY_RESPONSE_PATHWAY

LAMA5 FN1

1.95e-0430102M39641
PathwayREACTOME_MET_PROMOTES_CELL_MOTILITY

LAMA5 FN1

3.66e-0441102M27778
PathwayREACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS

LAMA5 FN1

7.58e-0459102M27218
PathwayPID_INTEGRIN1_PATHWAY

LAMA5 FN1

9.48e-0466102M18
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

LAMA5 CAPN10 FN1

1.02e-03300103M610
PathwayREACTOME_ECM_PROTEOGLYCANS

LAMA5 FN1

1.26e-0376102M27219
PathwayREACTOME_SIGNALING_BY_MET

LAMA5 FN1

1.36e-0379102M27643
PathwayKEGG_SMALL_CELL_LUNG_CANCER

LAMA5 FN1

1.53e-0384102M3228
PathwayKEGG_ECM_RECEPTOR_INTERACTION

LAMA5 FN1

1.53e-0384102M7098
PathwayREACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM

LAMA5 ILF2 POM121 FN1

1.56e-03789104M1060
PathwayWP_SMALL_CELL_LUNG_CANCER

LAMA5 FN1

1.99e-0396102M39834
PathwayREACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING

LAMA5 FN1

2.65e-03111102M27609
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

CAPN10 FN1

2.80e-03114102MM14571
PathwayWP_PLEURAL_MESOTHELIOMA

LAMA5 CDH16 FN1

3.06e-03439103M42563
Pubmed

Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells.

LAMA5 FN1

2.97e-06616216236823
Pubmed

alpha3beta1 Integrin is required for normal development of the epidermal basement membrane.

LAMA5 FN1

4.16e-0671629151677
Pubmed

Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt- and MEK1/ERK-dependent pathways.

LAMA5 FN1

4.16e-06716211891225
Pubmed

Beta1 integrins are required for the invasion of the caecum and proximal hindgut by enteric neural crest cells.

LAMA5 FN1

5.55e-06816219633172
Pubmed

Galectin-1 stimulates motility of human umbilical cord blood-derived mesenchymal stem cells by downregulation of smad2/3-dependent collagen 3/5 and upregulation of NF-κB-dependent fibronectin/laminin 5 expression.

LAMA5 FN1

5.55e-06816224503541
Pubmed

Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment.

LAMA5 FN1

5.55e-06816219651211
Pubmed

Expression of laminin alpha1, alpha2, alpha4, and alpha5 chains, fibronectin, and tenascin-C in skeletal muscle of dystrophic 129ReJ dy/dy mice.

LAMA5 FN1

7.13e-0691629882526
Pubmed

Membrane-type MMPs are indispensable for placental labyrinth formation and development.

LAMA5 FN1

1.80e-051416220858856
Pubmed

Ontogeny of stromal organizer cells during lymph node development.

LAMA5 FN1

2.37e-051616220237296
Pubmed

Cell-matrix signals specify bone endothelial cells during developmental osteogenesis.

LAMA5 FN1

2.37e-051616228218908
Pubmed

Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation.

LAMA5 FN1

2.37e-051616221067603
Pubmed

ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.

LAMA5 FN1

3.02e-051816239040056
Pubmed

Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53.

LAMA5 FN1

3.02e-051816211311202
Pubmed

GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126.

LAMA5 FN1

3.02e-051816231582413
Pubmed

Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis.

LAMA5 FN1

3.02e-051816219686679
Pubmed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

LAMA5 ILF2 FN1

3.90e-0514616327068509
Pubmed

Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis.

LAMA5 FN1

5.92e-052516219373938
Pubmed

Adamts18 modulates the development of the aortic arch and common carotid artery.

LAMA5 FN1

6.41e-052616234189436
Pubmed

Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.

LAMA5 FN1

8.00e-052916222613833
Pubmed

Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment.

CDH16 FN1

1.04e-043316236522157
Pubmed

Joint influence of small-effect genetic variants on human longevity.

TBC1D22A UVSSA

1.10e-043416220834067
Pubmed

Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.

LAMA5 FN1

1.31e-043716234323105
Pubmed

Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.

TBC1D19 TBC1D22A

1.77e-044316219077034
Pubmed

Functional dissection of Rab GTPases involved in primary cilium formation.

TBC1D19 TBC1D22A

1.77e-044316217646400
Pubmed

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.

LAMA5 FN1

2.40e-045016223658023
Pubmed

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis.

LAMA5 FN1

2.40e-045016224191021
CoexpressionNABA_MATRISOME_BLEO_FIBROTIC_LUNG

LAMA5 FN1

6.60e-0520162MM17053
CoexpressionHAN_SATB1_TARGETS_UP

LAMA5 CCPG1 CDH16 ARSA

1.06e-04425164M9639
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL

LAMA5 TBC1D22A CCPG1 ARSA POM121

1.98e-04955165M45680
CoexpressionNABA_ECM_GLYCOPROTEINS

VWA7 LAMA5 FN1

1.99e-04191163MM17059
CoexpressionNABA_ECM_GLYCOPROTEINS

VWA7 LAMA5 FN1

2.15e-04196163M3008
CoexpressionGSE23321_CD8_STEM_CELL_MEMORY_VS_NAIVE_CD8_TCELL_DN

TBC1D22A CCPG1 UVSSA

2.15e-04196163M8441
CoexpressionGSE17721_CPG_VS_GARDIQUIMOD_2H_BMDC_DN

POM121 CAPN10 FN1

2.28e-04200163M3882
Drugwortmannin; Up 200; 0.01uM; ssMCF7; HG-U133A

ALX3 TBC1D22A ARSA FN1

9.68e-06200164404_UP
DrugBM165

LAMA5 FN1

2.54e-0511162CID003352881
Diseaselongevity

TBC1D22A UVSSA ARSA

4.50e-04284163EFO_0004300
DiseaseAntihypertensive use measurement

TBC1D19 CDH16

8.87e-03265162EFO_0009927

Protein segments in the cluster

PeptideGeneStartEntry
SAAHPGIYSIHGFPP

ALX3

291

O95076
EFHPIGFHIFQVPEG

CAPN10

571

Q9HC96
PPHQGFHRFLGIPYS

ARSA

136

P15289
FLLHGYQPAHPTFPV

LAMA5

1301

O15230
YVPTPIHPIFGGATH

POM121

1021

Q96HA1
RHFFGHTFSPPYGPR

CCPG1

731

Q9ULG6
PREDVDYHLYPHGPG

FN1

2181

P02751
GGFRPFVPHIPFDFY

ILF2

21

Q12905
GDVHYHLESHPPGPF

CDH16

266

O75309
GYEPHIPDHLRPEYG

UVSSA

416

Q2YD98
FIPHEGPGPGHYNVK

STPG4

171

Q8N801
YGAQHPPFDPLLHGT

TBC1D22A

26

Q8WUA7
VFYPPNGVIPFHGFS

TBC1D19

356

Q8N5T2
PVHYVLVPFHDPGFG

VWA7

351

Q9Y334
RKPPDHVFHSGPFIY

TDH

86

Q8IZJ6
HELGVAHPPGYPLFT

TMEM260

61

Q9NX78