Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	guanylate kinase activity	MPP1 TJP2 CASK	6.11e-06	11	68	3	GO:0004385
GeneOntologyMolecularFunction	C-rich single-stranded DNA binding	PCBP3 PCBP2	3.42e-05	3	68	2	GO:1990829
GeneOntologyMolecularFunction	nucleoside monophosphate kinase activity	MPP1 TJP2 CASK	6.37e-05	23	68	3	GO:0050145
GeneOntologyMolecularFunction	ISG15 transferase activity	UBE2E1 UBE2E2	6.83e-05	4	68	2	GO:0042296
GeneOntologyMolecularFunction	ubiquitin conjugating enzyme activity	UBE2K UBE2E1 UBE2E2	2.70e-04	37	68	3	GO:0061631
GeneOntologyMolecularFunction	phosphotransferase activity, phosphate group as acceptor	MPP1 TJP2 CASK	3.67e-04	41	68	3	GO:0016776
GeneOntologyMolecularFunction	ubiquitin-like protein conjugating enzyme activity	UBE2K UBE2E1 UBE2E2	4.23e-04	43	68	3	GO:0061650
GeneOntologyMolecularFunction	nucleobase-containing compound kinase activity	MPP1 TJP2 CASK	5.50e-04	47	68	3	GO:0019205
GeneOntologyMolecularFunction	actin filament binding	ABL1 VILL XIRP2 MYO16 DMTN	1.06e-03	227	68	5	GO:0051015
GeneOntologyMolecularFunction	SH3 domain binding	DOCK4 ENKUR ABL1 LRP2	1.44e-03	143	68	4	GO:0017124
GeneOntologyBiologicalProcess	GDP metabolic process	MPP1 TJP2 CASK	5.31e-06	11	67	3	GO:0046710
GeneOntologyCellularComponent	nuclear matrix	KIF4A SMARCC2 PRKCD KIF4B CASK	9.99e-05	140	69	5	GO:0016363
GeneOntologyCellularComponent	actin cytoskeleton	ABL1 ARSJ VILL XIRP2 LPP SRCIN1 MYO16 DMTN CASK	1.12e-04	576	69	9	GO:0015629
GeneOntologyCellularComponent	nuclear periphery	KIF4A SMARCC2 PRKCD KIF4B CASK	2.54e-04	171	69	5	GO:0034399
GeneOntologyCellularComponent	anchoring junction	MPP1 PTPRA XIRP2 AMOTL1 LPP TJP2 PRKCD SRCIN1 PCBP2 VSIG10L2 CASK	3.30e-04	976	69	11	GO:0070161
Domain	UBQ-conjugating_enzyme/RWD	UBE2K UBE2E1 UBE2E2 UBE2V2 DHX57	1.19e-06	53	66	5	IPR016135
Domain	UQ_con	UBE2K UBE2E1 UBE2E2 UBE2V2	1.07e-05	39	66	4	PF00179
Domain	UBIQUITIN_CONJUGAT_1	UBE2K UBE2E1 UBE2E2 UBE2V2	1.18e-05	40	66	4	PS00183
Domain	UBQ-conjugat_E2	UBE2K UBE2E1 UBE2E2 UBE2V2	1.31e-05	41	66	4	IPR000608
Domain	UBIQUITIN_CONJUGAT_2	UBE2K UBE2E1 UBE2E2 UBE2V2	1.31e-05	41	66	4	PS50127
Domain	-	UBE2K UBE2E1 UBE2E2 UBE2V2	3.14e-05	51	66	4	3.10.110.10
Domain	GUANYLATE_KINASE_2	MPP1 TJP2 CASK	7.10e-05	23	66	3	PS50052
Domain	GUANYLATE_KINASE_1	MPP1 TJP2 CASK	7.10e-05	23	66	3	PS00856
Domain	UBQ-conjugating_AS	UBE2K UBE2E1 UBE2E2	9.17e-05	25	66	3	IPR023313
Domain	Guanylate_kin	MPP1 TJP2 CASK	1.03e-04	26	66	3	PF00625
Domain	GK/Ca_channel_bsu	MPP1 TJP2 CASK	1.03e-04	26	66	3	IPR008145
Domain	Guanylate_kin-like_dom	MPP1 TJP2 CASK	1.03e-04	26	66	3	IPR008144
Domain	GuKc	MPP1 TJP2 CASK	1.03e-04	26	66	3	SM00072
Domain	SH3_2	MPP1 DOCK4 TJP2 CASK	2.43e-04	86	66	4	IPR011511
Domain	SH3_2	MPP1 DOCK4 TJP2 CASK	2.43e-04	86	66	4	PF07653
Domain	KH_1	PCBP3 PCBP2 SF1	3.25e-04	38	66	3	PF00013
Domain	HP	VILL DMTN	3.40e-04	8	66	2	PS51089
Domain	-	VILL DMTN	3.40e-04	8	66	2	1.10.950.10
Domain	VHP	VILL DMTN	3.40e-04	8	66	2	PF02209
Domain	Villin_headpiece	VILL DMTN	3.40e-04	8	66	2	IPR003128
Domain	VHP	VILL DMTN	3.40e-04	8	66	2	SM00153
Domain	-	PCBP3 PCBP2 SF1	3.52e-04	39	66	3	3.30.1370.10
Domain	KH	PCBP3 PCBP2 SF1	3.79e-04	40	66	3	SM00322
Domain	KH_dom	PCBP3 PCBP2 SF1	3.79e-04	40	66	3	IPR004087
Domain	PapD-like	HYDIN CFAP65	4.36e-04	9	66	2	IPR008962
Domain	KH_TYPE_1	PCBP3 PCBP2 SF1	4.38e-04	42	66	3	PS50084
Domain	KH_dom_type_1	PCBP3 PCBP2 SF1	5.03e-04	44	66	3	IPR004088
Domain	SH3	MPP1 DOCK4 ABL1 TJP2 CASK	9.96e-04	216	66	5	SM00326
Domain	SH3	MPP1 DOCK4 ABL1 TJP2 CASK	9.96e-04	216	66	5	PS50002
Domain	SH3_domain	MPP1 DOCK4 ABL1 TJP2 CASK	1.08e-03	220	66	5	IPR001452
Domain	Guanylate_kinase_CS	MPP1 CASK	1.43e-03	16	66	2	IPR020590
Domain	P-loop_NTPase	MPP1 ABCF1 TJP2 KIF4A DHX57 KIF4B HYDIN MYO16 CASK	2.85e-03	848	66	9	IPR027417
Pubmed	Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting.	UBE2K UBE2E1 UBE2E2 UBE2V2	2.02e-08	15	70	4	32265276
Pubmed	New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.	RC3H2 UBE2K UBE2E2 UBE2V2	3.51e-08	17	70	4	26489670
Pubmed	E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages.	UBE2K UBE2E1 UBE2E2	4.34e-07	8	70	3	17873885
Pubmed	E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis.	UBE2K UBE2E1 UBE2E2	4.34e-07	8	70	3	24446487
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	DMXL2 MAN2A2 UBE2E1 FN1 XIRP2 RIOK3 COL14A1 MGA SF1	6.94e-07	497	70	9	23414517
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ABCF1 FN1 SF3A1 CANX TJP2 KIF4A SMARCC2 DHX57 COPG2 NSUN2	7.32e-07	653	70	10	22586326
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DMXL2 ABCF1 PTPRA FN1 TJP2 MAP7D2 SMARCC2 DHX57 SRCIN1 TANC1 PLEKHA6 DMTN CNTN1 CASK	8.34e-07	1431	70	14	37142655
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DOCK4 CASC3 ABL1 LPP TJP2 AKAP11 TANC1 CRYBG3 BRD1 FGD6 DMTN	1.15e-06	861	70	11	36931259
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	DOCK4 DMXL2 UBE2K VILL CANX AMOTL1 LPP SRCIN1 MGA FGD6	1.19e-06	689	70	10	36543142
Pubmed	Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination.	UBE2K UBE2E1 UBE2E2	1.27e-06	11	70	3	19712108
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CASC3 DMXL2 UBE2V2 NHSL2 CANX KIF4A SMARCC2 KIF4B MGA CNTN1 CASK	3.37e-06	963	70	11	28671696
Pubmed	E3 ligases determine ubiquitination site and conjugate type by enforcing specificity on E2 enzymes.	UBE2K UBE2E1 UBE2E2	3.49e-06	15	70	3	21965653
Pubmed	KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway.	KIF4A KIF4B	3.99e-06	2	70	2	36482480
Pubmed	Whole genome expression microarray reveals novel roles for Kif4 in monocyte/macrophage cells.	KIF4A KIF4B	3.99e-06	2	70	2	31486502
Pubmed	Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization.	KIF4A KIF4B	3.99e-06	2	70	2	10773663
Pubmed	The multiple functions of kinesin-4 family motor protein KIF4 and its clinical potential.	KIF4A KIF4B	3.99e-06	2	70	2	30081192
Pubmed	Missense Pathogenic variants in KIF4A Affect Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus.	KIF4A KIF4B	3.99e-06	2	70	2	31616463
Pubmed	Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis.	KIF4A KIF4B	3.99e-06	2	70	2	31067151
Pubmed	Kif4 regulates the expression of VEGFR1 through the PI3K/Akt signaling pathway in RAW264.7 monocytes/macrophages.	KIF4A KIF4B	3.99e-06	2	70	2	28350061
Pubmed	Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells.	ABL1 PRKCD	3.99e-06	2	70	2	17126298
Pubmed	Cellular motor protein KIF-4 associates with retroviral Gag.	KIF4A KIF4B	3.99e-06	2	70	2	10559369
Pubmed	Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts.	KIF4A KIF4B	3.99e-06	2	70	2	24658398
Pubmed	KIF4 regulates midzone length during cytokinesis.	KIF4A KIF4B	3.99e-06	2	70	2	21565503
Pubmed	Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress.	ABL1 PRKCD	3.99e-06	2	70	2	10713049
Pubmed	A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally.	KIF4A KIF4B	3.99e-06	2	70	2	7929562
Pubmed	Proteomic identification of plasma protein tyrosine phosphatase alpha and fibronectin associated with liver fluke, Opisthorchis viverrini, infection.	PTPRA FN1	3.99e-06	2	70	2	23029023
Pubmed	Structural basis for the ATP-induced isomerization of kinesin.	KIF4A KIF4B	3.99e-06	2	70	2	23500491
Pubmed	Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.	KIF4A KIF4B	3.99e-06	2	70	2	9658142
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	MPP1 ABCF1 FN1 XIRP2 TJP2 DHX57 SRCIN1 HYDIN	7.14e-06	497	70	8	36774506
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	ABCF1 TJP2 SMARCC2 SRCIN1 PLEKHA6 DMTN	7.40e-06	231	70	6	16452087
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	MPP1 CASC3 ABCF1 UBE2E1 SF3A1 CANX TJP2 COPG2 FAR1 PCBP2 NSUN2 SF1	1.16e-05	1318	70	12	30463901
Pubmed	Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP.	AMOTL1 TJP2	1.20e-05	3	70	2	21685940
Pubmed	Mapping of p140Cap phosphorylation sites: the EPLYA and EGLYA motifs have a key role in tyrosine phosphorylation and Csk binding, and are substrates of the Abl kinase.	ABL1 SRCIN1	1.20e-05	3	70	2	23383002
Pubmed	The c-Abl tyrosine kinase controls protein kinase Cδ-induced Fli-1 phosphorylation in human dermal fibroblasts.	ABL1 PRKCD	1.20e-05	3	70	2	21321929
Pubmed	Claudin-1 acts through c-Abl-protein kinase Cdelta (PKCdelta) signaling and has a causal role in the acquisition of invasive capacity in human liver cells.	ABL1 PRKCD	1.20e-05	3	70	2	19897486
Pubmed	Tumor formation via loss of a molecular motor protein.	KIF4A KIF4B	1.20e-05	3	70	2	16890532
Pubmed	KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons.	KIF4A KIF4B	1.20e-05	3	70	2	19158085
Pubmed	c-Abl tyrosine kinase promotes adipocyte differentiation by targeting PPAR-gamma 2.	PPARGC1A ABL1	1.20e-05	3	70	2	25368164
Pubmed	Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein.	KIF4A KIF4B	1.20e-05	3	70	2	10978527
Pubmed	KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity.	KIF4A KIF4B	1.20e-05	3	70	2	16630823
Pubmed	Ndrg2 is a PGC-1α/ERRα target gene that controls protein synthesis and expression of contractile-type genes in C2C12 myotubes.	PPARGC1A NDRG2	1.20e-05	3	70	2	24008097
Pubmed	CircKIF4A enhances osteosarcoma proliferation and metastasis by sponging MiR-515-5p and upregulating SLC7A11.	KIF4A KIF4B	1.20e-05	3	70	2	35579738
Pubmed	Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha.	PTPRA PRKCD	1.20e-05	3	70	2	12826681
Pubmed	Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.	RC3H2 UBE2K UBE2E1 UBE2E2 UBE2V2	1.30e-05	149	70	5	19549727
Pubmed	The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway.	UBE2K UBE2E1 UBE2E2	1.34e-05	23	70	3	30017913
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	RC3H2 PCBP3 CANX SMARCC2 DHX57 PCBP2 NSUN2 SF1 CASK	1.45e-05	723	70	9	34133714
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ABCF1 FN1 KIF4A SMARCC2 PRKCD DHX57 RIOK3 TANC1 FAR1 MGA NSUN2 IL36G	1.51e-05	1353	70	12	29467282
Pubmed	Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.	UBE2K UBE2E1 UBE2E2	1.53e-05	24	70	3	24647965
Pubmed	Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.	CANX MGA PCBP2 NSUN2 SF1	1.63e-05	156	70	5	37108203
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	CASC3 RC3H2 MAN2A2 FN1 SF3A1 TJP2 SMARCC2 DHX57 COL14A1 PCBP2 NSUN2 SF1	1.72e-05	1371	70	12	36244648
Pubmed	Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.	UBE2K UBE2E1 UBE2E2	1.74e-05	25	70	3	17597759
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	LPP TJP2 COPG2 SRCIN1 TANC1 PLEKHA6 PCBP2 NDRG2	1.80e-05	565	70	8	25468996
Pubmed	The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.	UBE2K UBE2E1 UBE2E2	1.96e-05	26	70	3	20061386
Pubmed	Functional interactions between ubiquitin E2 enzymes and TRIM proteins.	UBE2E1 UBE2E2 UBE2V2	2.21e-05	27	70	3	21143188
Pubmed	Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta.	ABL1 PRKCD	2.39e-05	4	70	2	15289456
Pubmed	A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins.	PCBP3 PCBP2	2.39e-05	4	70	2	14612387
Pubmed	Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo.	SF3A1 SF1	2.39e-05	4	70	2	15647371
Pubmed	Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta.	PTPRA PRKCD	2.39e-05	4	70	2	11676480
Pubmed	Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.	ABL1 PRKCD	2.39e-05	4	70	2	28428613
Pubmed	PPAR-gamma coactivator-1alpha regulates progesterone production in ovarian granulosa cells with SF-1 and LRH-1.	PPARGC1A SF1	2.39e-05	4	70	2	20133449
Pubmed	Nuclear import of LASP-1 is regulated by phosphorylation and dynamic protein-protein interactions.	LPP TJP2	2.39e-05	4	70	2	22665060
Pubmed	Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein.	KIF4A KIF4B	2.39e-05	4	70	2	18684836
Pubmed	Repair of noise-induced damage to stereocilia F-actin cores is facilitated by XIRP2 and its novel mechanosensor domain.	XIRP2 PTPRQ	2.39e-05	4	70	2	37294664
Pubmed	Kif4 Is Essential for Mouse Oocyte Meiosis.	KIF4A KIF4B	2.39e-05	4	70	2	28125646
Pubmed	Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation.	PTPRA PRKCD	2.39e-05	4	70	2	11923305
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ABCF1 SF3A1 TJP2 KIAA1958 SMARCC2 PRKCD ZFPM1 NSUN2 SF1	2.47e-05	774	70	9	15302935
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	FN1 CALHM1 AMOTL1 VPS13A TJP2 KIF4A COPG2 MGA CASK	2.55e-05	777	70	9	35844135
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	CASC3 RC3H2 ABCF1 SF3A1 CANX DHX57 PCBP2 NSUN2 SF1	3.42e-05	807	70	9	22681889
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	ABCF1 FN1 SF3A1 CANX MAP7D2 TANC1 PCBP2 NSUN2 CASK	3.49e-05	809	70	9	32129710
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	ABCF1 SF3A1 CANX KIF4A SMARCC2 COPG2 PLEKHA6 MGA PCBP2 NSUN2 SF1	3.75e-05	1247	70	11	27684187
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ABCF1 SF3A1 CANX TJP2 SMARCC2 FAR1 MGA PCBP2 NSUN2 SF1	3.75e-05	1024	70	10	24711643
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DMXL2 ABCF1 SF3A1 CANX VPS13A MAP7D2 COL14A1 AKAP11 TANC1 CRYBG3 FAR1 CASK	3.81e-05	1487	70	12	33957083
Pubmed	The RING Domain of RING Finger 12 Efficiently Builds Degradative Ubiquitin Chains.	UBE2K UBE2E2	3.98e-05	5	70	2	32416094
Pubmed	RING E3-Catalyzed E2 Self-Ubiquitination Attenuates the Activity of Ube2E Ubiquitin-Conjugating Enzymes.	UBE2E1 UBE2E2	3.98e-05	5	70	2	25960396
Pubmed	Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme.	UBE2E1 UBE2E2	3.98e-05	5	70	2	16428300
Pubmed	Each member of the poly-r(C)-binding protein 1 (PCBP) family exhibits iron chaperone activity toward ferritin.	PCBP3 PCBP2	3.98e-05	5	70	2	23640898
Pubmed	p73beta is regulated by protein kinase Cdelta catalytic fragment generated in the apoptotic response to DNA damage.	ABL1 PRKCD	3.98e-05	5	70	2	12097319
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	MPP1 UBE2E1 UBE2E2 AMOTL1 RIOK3 TANC1	4.79e-05	322	70	6	39098523
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	DOCK4 UBE2K SF3A1 AMOTL1 TJP2 KIF4A DHX57 RIOK3 COPG2 AKAP11 FAR1	4.88e-05	1284	70	11	17353931
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	ABCF1 SMARCC2 DHX57 FAR1 PCBP2 NSUN2 SF1	5.59e-05	486	70	7	30940648
Pubmed	Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1.	UBE2E1 UBE2E2	5.96e-05	6	70	2	30349006
Pubmed	The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2.	UBE2E1 UBE2E2	5.96e-05	6	70	2	20484052
Pubmed	Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes.	UBE2E1 UBE2E2	5.96e-05	6	70	2	11274149
Pubmed	Activation of Bak and Bax through c-abl-protein kinase Cdelta-p38 MAPK signaling in response to ionizing radiation in human non-small cell lung cancer cells.	ABL1 PRKCD	5.96e-05	6	70	2	16410245
Pubmed	N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8.	UBE2E1 UBE2E2	5.96e-05	6	70	2	11322894
Pubmed	Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins.	PCBP3 PCBP2	5.96e-05	6	70	2	10936052
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	RC3H2 LPP AKAP11 TANC1 CRYBG3	6.58e-05	209	70	5	36779422
Pubmed	New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation.	DOCK4 PPARGC1A COL14A1	7.31e-05	40	70	3	19864314
Pubmed	Analysis of electrostatic contributions to the selectivity of interactions between RING-finger domains and ubiquitin-conjugating enzymes.	UBE2E1 UBE2E2	8.33e-05	7	70	2	18615712
Pubmed	Genetic mapping in the mouse of Kif4, a gene encoding a kinesin-like motor protein.	KIF4A KIF4B	8.33e-05	7	70	2	9196009
Pubmed	Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity.	UBE2E1 UBE2E2	8.33e-05	7	70	2	31028095
Pubmed	Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells.	KIF4A KIF4B	8.33e-05	7	70	2	23362347
Pubmed	Kinesin family in murine central nervous system.	KIF4A KIF4B	8.33e-05	7	70	2	1447303
Pubmed	PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.	PPARGC1A UBE2E1	8.33e-05	7	70	2	21376232
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	MPP1 RC3H2 PCBP3 TJP2 DHX57 MGA PCBP2 SF1	1.03e-04	724	70	8	36232890
Pubmed	The mechanism of neural precursor cell expressed developmentally down-regulated 4-2 (Nedd4-2)/NEDD4L-catalyzed polyubiquitin chain assembly.	UBE2E1 UBE2E2	1.11e-04	8	70	2	28972136
Pubmed	Genetic variations strongly influence phenotypic outcome in the mouse retina.	RPGRIP1 KIF4A KIF4B	1.11e-04	46	70	3	21779340
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	MPP1 CASC3 AMOTL1 LPP TJP2 KIF4A TANC1 MGA	1.12e-04	733	70	8	34672954
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	RC3H2 ABCF1 CANX DHX57 FAR1 MGA NSUN2	1.17e-04	547	70	7	37267103
Pubmed	Evidence of SARS-CoV-2 infection in postmortem lung, kidney, and liver samples, revealing cellular targets involved in COVID-19 pathogenesis.	PPARGC1A FN1	1.42e-04	9	70	2	36842152
Interaction	LPA interactions	FN1 CANX LRP2	6.21e-06	11	69	3	int:LPA
Cytoband	3p24.2	UBE2E1 UBE2E2	3.85e-04	19	70	2	3p24.2
GeneFamily	Ubiquitin conjugating enzymes E2	UBE2K UBE2E1 UBE2E2 UBE2V2	4.48e-06	41	49	4	102
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	MPP1 TJP2 CASK	4.66e-05	26	49	3	904
GeneFamily	Fibronectin type III domain containing	FN1 PTPRQ COL14A1 CNTN1	9.18e-04	160	49	4	555
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRA PTPRQ	1.46e-03	21	49	2	813
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF4A KIF4B	6.90e-03	46	49	2	622
GeneFamily	PDZ domain containing	MPP1 TJP2 CASK	8.09e-03	152	49	3	1220
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	DOCK4 PPARGC1A ZFHX2 MAP7D2 SMARCC2 SRCIN1 PLEKHA6 REV3L BRD1 HYDIN DMTN CNTN1 CASK	6.35e-06	1106	70	13	M39071
Coexpression	GSE41867_DAY6_EFFECTOR_VS_DAY30_EXHAUSTED_CD8_TCELL_LCMV_CLONE13_DN	UBE2K CRYBG3 FAR1 MGA NSUN2 CASK	1.60e-05	200	70	6	M9490
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A XIRP2 PTPRQ LRP2 HYDIN MYO16 CNTN1	1.65e-08	184	70	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A XIRP2 PTPRQ LRP2 HYDIN MYO16 CNTN1	1.65e-08	184	70	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A XIRP2 PTPRQ LRP2 HYDIN MYO16 CNTN1	1.65e-08	184	70	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ENKUR ZFHX2 KIF4A HYDIN CFAP99 CFAP65	6.78e-07	197	70	6	6e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCell	Control_saline-Mesenchymal_fibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	DOCK4 FN1 COL14A1 PLEKHA6 NDRG2 MYO16	7.41e-07	200	70	6	64ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts\|Control_saline / Treatment groups by lineage, cell group, cell type	DOCK4 FN1 COL14A1 PLEKHA6 NDRG2 MYO16	7.41e-07	200	70	6	a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCell	IIF\|World / Disease, Lineage and Cell Type	MPP1 RIOK3 SF1 DMTN CASK	7.00e-06	169	70	5	ebf726f725079317ad67c2f754748b4112607277
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A PRKCD ZFPM1 NDRG2 CASK	7.84e-06	173	70	5	7a3115e7cf7e2f345192cde0656a7f0193594a5f
ToppCell	Adult-Epithelial-ciliated_cell-D175\|Adult / Lineage, Cell type, age group and donor	ENKUR ZFHX2 HYDIN CFAP99 CFAP65	1.09e-05	185	70	5	30f4980dee6cd5959655f8d74049f3bfb5312611
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Hematopoietic\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MPP1 ENKUR XIRP2 KIF4A DMTN	1.14e-05	187	70	5	46e15419e80bd7180f3171a99d845b01bb635e53
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Hematopoietic-Megakaryocytic-Megakaryocyte\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MPP1 ENKUR XIRP2 KIF4A DMTN	1.14e-05	187	70	5	0d17b07770e4c881a7ca53a5bd42471457d198fb
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Hematopoietic-Megakaryocytic\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MPP1 ENKUR XIRP2 KIF4A DMTN	1.14e-05	187	70	5	69068480f6819a6c8560ecbb05deb156b4055e12
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MPP1 ENKUR XIRP2 KIF4A DMTN	1.14e-05	187	70	5	9c8b932a15b8b50982cba4cf8db750e257eb9503
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DOCK4 PPARGC1A ARSJ PTPRQ MYO16	1.23e-05	190	70	5	30b50d183d7649146eb1e79b47ba897355f1998a
ToppCell	wk_08-11-Hematologic-Meg-ery-Definitive_erythroblast\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	MPP1 MAN2A2 RIOK3 ZFPM1 DMTN	1.33e-05	193	70	5	be75abfdf5301cf33df8ee9ed92504d44fdf19a6
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 COL14A1 TANC1 CRYBG3 REV3L	1.43e-05	196	70	5	2ab9735aa7a7e95dcf6b0bdf0427f7b57f6349ee
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DOCK4 FN1 COL14A1 REV3L MYO16	1.58e-05	200	70	5	9b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PPARGC1A AMOTL1 LPP TANC1 MYO16	1.58e-05	200	70	5	1276bfa911fddada4235e12e3081baa53164574b
ToppCell	MS-IIF\|MS / Disease, condition lineage and cell class	MPP1 RIOK3 SF1 DMTN CASK	1.58e-05	200	70	5	221f59edcfc18baece13184c2552d26022228146
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	DOCK4 FN1 COL14A1 PLEKHA6 MYO16	1.58e-05	200	70	5	bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LPP NDRG2 FGD6 CNTN1	6.64e-05	138	70	4	6b83c434895d82eaf3c222eef27acec76f9c0a77
ToppCell	LPS-antiTNF-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ENKUR HYDIN CFAP99 CFAP65	8.71e-05	148	70	4	d61123f0c811287843d066b932b4a9ff09c07c5b
ToppCell	LPS-antiTNF-Epithelial_airway-Ciliated_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ENKUR HYDIN CFAP99 CFAP65	8.71e-05	148	70	4	c8e93b87212f55774223caa385859c566fa1981f
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-matrix_-_immature_3\|E16.5-samps / Age Group, Lineage, Cell class and subclass	DOCK4 KIF4A COL14A1 PLEKHA6	8.94e-05	149	70	4	651494e84be03dc7b061ebdfa91756a1c507b9b4
ToppCell	Control-Epithelial_airway-Ciliated_cells-Ciliated\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ENKUR HYDIN CFAP99 CFAP65	1.02e-04	154	70	4	4e3bc24043144143842627cacf6f90dda2228910
ToppCell	Control-Epithelial_airway-Ciliated_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ENKUR HYDIN CFAP99 CFAP65	1.02e-04	154	70	4	7556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ENKUR HYDIN CFAP99 CFAP65	1.04e-04	155	70	4	5f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ENKUR HYDIN CFAP99 CFAP65	1.04e-04	155	70	4	0944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-cortical_neurons_1\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	PPARGC1A MAP7D2 DMTN CNTN1	1.12e-04	158	70	4	1f94622186d8329357fa06785e03eeacf29ab1ce
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Ciliated_2\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	PPARGC1A ENKUR SRCIN1 HYDIN	1.32e-04	165	70	4	731147b4337fd0de4383dc8170b4f9ccd98caec6
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 TANC1 CRYBG3 REV3L	1.45e-04	169	70	4	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l48\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CASC3 DHX57 COPG2 POLR3G	1.49e-04	170	70	4	070d8683d1a5cc7d594ff0453c961a9bf982c2d0
ToppCell	COVID-19-lung-RBC\|lung / Disease (COVID-19 only), tissue and cell type	MPP1 XIRP2 ZFPM1 DMTN	1.52e-04	171	70	4	0e8d63c8fbccdda4f1ef00de00667a50464b104b
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 VILL PRKCD AKAP11	1.59e-04	173	70	4	3c51e7bda1835c25915e50c801b0d643979971a3
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VILL AKNA ZFHX2 ZFPM1	1.59e-04	173	70	4	c31076c725f4cd912c56903592a2d9356ae59f54
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 VILL PRKCD AKAP11	1.59e-04	173	70	4	a042f78a4c69fcc6b5ca76e9bf01e34cee54c81c
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VILL AKNA ZFHX2 ZFPM1	1.59e-04	173	70	4	a4ed191cfdf6588b7f3672995bf0a4fe9e4b8df6
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARSJ KIF4A COL14A1 CRYBG3	1.62e-04	174	70	4	6c36d607c48267a75ab4da6fb2fe3f931d1b3b52
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	DOCK4 PPARGC1A PTPRQ MYO16	1.62e-04	174	70	4	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MPP1 VILL CFAP65	1.68e-04	68	70	3	a54903d0368e57d62608693d1f6764526d6e38b2
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A XIRP2 COL14A1 NDRG2	1.70e-04	176	70	4	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	(9)_Platelet\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	MPP1 ENKUR XIRP2 DMTN	1.73e-04	177	70	4	0830944c43de300815831a9e2b2fce40965e7d12
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENKUR LRP2 HYDIN CFAP65	1.73e-04	177	70	4	ae01c19403a09f7ba5e4beafdfcd1b8eebdadcb7
ToppCell	(9)_Platelet\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	MPP1 ENKUR XIRP2 DMTN	1.73e-04	177	70	4	e63d01c7fce4fa1256212fa7e95f74281edb3a01
ToppCell	Healthy-RBC\|Healthy / disease group, cell group and cell class	MPP1 KIF4A CFAP99 DMTN	1.73e-04	177	70	4	945d72ab52efa9a9468daace9f9ec676a891d963
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NHSL2 AMOTL1 COPG2 TANC1	1.73e-04	177	70	4	8ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENKUR LRP2 HYDIN CFAP65	1.73e-04	177	70	4	bd3d07bdef6e903995d4bbfb6ff3a5e1d9fb70cc
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MPP1 ENKUR XIRP2 DMTN	1.77e-04	178	70	4	f5d83ad082e31d5601890d245b9fb4f9ef6a062b
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet-Platelet\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MPP1 ENKUR XIRP2 DMTN	1.77e-04	178	70	4	a2a8fc14f492a4695e6991a357b6626145f1bf7f
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet-Platelet\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MPP1 ENKUR XIRP2 DMTN	1.81e-04	179	70	4	510927794bbd21814eba75286e0801eb1fd2e8a6
ToppCell	PBMC-Convalescent-Hematopoietic\|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)	MPP1 ENKUR XIRP2 DMTN	1.81e-04	179	70	4	3b1616e974ea7792ff5c37da3b0281f28edfbb56
ToppCell	PBMC-Convalescent-Hematopoietic\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MPP1 ENKUR XIRP2 DMTN	1.81e-04	179	70	4	35271a4396a533f6d960ce55d171a32d9d2fd1a4
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MPP1 ENKUR XIRP2 DMTN	1.81e-04	179	70	4	906a5ebbbac660b6fd498ced09d0ada40a3e64af
ToppCell	normal_Pleural_Fluid-Myeloid_cells-mo-Mac\|normal_Pleural_Fluid / Location, Cell class and cell subclass	MPP1 DOCK4 FN1 IL36G	1.81e-04	179	70	4	cd3c58e044f5a38e815313a1636153d81a592fce
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARSJ COL14A1 PLEKHA6 MYO16	1.85e-04	180	70	4	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	Ciliated_cells-B-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	ENKUR SRCIN1 HYDIN CFAP65	1.85e-04	180	70	4	bdea5ec6b60fc8c7cce4d71db5da74ac8675e211
ToppCell	COVID-19_Convalescent-Hematopoietic_Mega-Platelet\|COVID-19_Convalescent / Disease group, lineage and cell class	MPP1 ENKUR XIRP2 DMTN	1.85e-04	180	70	4	deed53167504c91220b35a63366ed7d8f02a5254
ToppCell	COVID-19_Convalescent-Hematopoietic_Mega\|COVID-19_Convalescent / Disease group, lineage and cell class	MPP1 ENKUR XIRP2 DMTN	1.85e-04	180	70	4	17323d382ae322e388e230fdad13e3464ea73e8e
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARSJ COL14A1 PLEKHA6 MYO16	1.85e-04	180	70	4	9b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PPARGC1A AMOTL1 TANC1 MYO16	1.89e-04	181	70	4	bd7e9437839bca543ca5945df43d6525e6a312a8
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	DOCK4 FN1 COL14A1 NDRG2	1.93e-04	182	70	4	ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENKUR LRP2 HYDIN CFAP65	1.93e-04	182	70	4	587636c0f127231de21acd8aa632b74ff22ca8c2
ToppCell	wk_20-22-Hematologic-Meg-ery-Definitive_erythroblast\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	MPP1 MAN2A2 RIOK3 DMTN	1.93e-04	182	70	4	0c77ef4556c1d1512ebe9077df858b28f9e38dd5
ToppCell	remission-Platelet\|remission / disease stage, cell group and cell class	MPP1 ENKUR XIRP2 DMTN	1.93e-04	182	70	4	65e2798aacd670cbc3a8c8e9d1a2f7768513bb70
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENKUR LRP2 HYDIN CFAP65	1.93e-04	182	70	4	adfadd7893e74b3002f13f00875e3667d3493e0c
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	DOCK4 COL14A1 CRYBG3 REV3L	2.01e-04	184	70	4	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MPP1 ENKUR XIRP2 DMTN	2.05e-04	185	70	4	9bff336510c80cd762b4e41b4570475033e709ca
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MPP1 ENKUR XIRP2 DMTN	2.05e-04	185	70	4	452d49c7835a4d55e41caefa44dac5cab30e7ced
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic-Megakaryocytic-Megakaryocyte\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MPP1 ENKUR XIRP2 DMTN	2.05e-04	185	70	4	53f5136ee1bd101dd5ac8a2c9e63b0c3b987657e
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic-Megakaryocytic\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MPP1 ENKUR XIRP2 DMTN	2.05e-04	185	70	4	67ac5c2bacdbdcb40ee65c44da55b3f597b410ee
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Hematopoietic-Megakaryocytic-Megakaryocyte\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MPP1 ENKUR XIRP2 DMTN	2.10e-04	186	70	4	9e2e8e2c3de711734cdb4775bafb0757b4db97b1
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MPP1 ENKUR XIRP2 DMTN	2.10e-04	186	70	4	8fbf5cb31192066b4c202f80baf6d7f2bdefedb9
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Hematopoietic\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MPP1 ENKUR XIRP2 DMTN	2.10e-04	186	70	4	1dfd3fc4012bf0254adfa1f5eddadc9b6107455b
ToppCell	10x5'-Liver-Myeloid_Dendritic-DC1\|Liver / Manually curated celltypes from each tissue	TJP2 KIAA1958 CRYBG3 NDRG2	2.10e-04	186	70	4	e823529ffd06352c6bdec102f221fdf27f7c7369
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Hematopoietic-Megakaryocytic\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MPP1 ENKUR XIRP2 DMTN	2.10e-04	186	70	4	49d23c985b2f5e16790f4d7ccf81ef7b794c0877
ToppCell	IIF-Other\|IIF / Disease, Lineage and Cell Type	MPP1 ENKUR RIOK3 DMTN	2.14e-04	187	70	4	ae44d9261698cc0289750a546baf050f78b119b3
ToppCell	droplet-Lung-LUNG-1m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENKUR SRCIN1 HYDIN CFAP65	2.14e-04	187	70	4	0334fb1247a5800bf1438a48da8fd905df000d89
ToppCell	Multiple_Sclerosis-Other\|Multiple_Sclerosis / Disease, Lineage and Cell Type	MPP1 ENKUR RIOK3 DMTN	2.14e-04	187	70	4	ca6f53e841fd016804e6e8ccf0199877b0e5cbdd
ToppCell	severe-Platelet\|World / disease stage, cell group and cell class	MPP1 ENKUR XIRP2 DMTN	2.14e-04	187	70	4	72475fb6d053354b581e61c6eee3719a7dd08c8b
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1\|Adult / Lineage, Cell type, age group and donor	ARSJ PTPRQ TANC1 MYO16	2.14e-04	187	70	4	77f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell	Healthy_donor-Platelet\|Healthy_donor / disease group, cell group and cell class (v2)	MPP1 ENKUR XIRP2 DMTN	2.14e-04	187	70	4	9040ffa5c23913b9dc0205fa6227223c2a2847ae
ToppCell	droplet-Lung-LUNG-1m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENKUR SRCIN1 HYDIN CFAP65	2.14e-04	187	70	4	cf8e3448402e1d05b8321a5f124bd29e30e18841
ToppCell	remission-Platelet\|World / disease stage, cell group and cell class	MPP1 ENKUR XIRP2 DMTN	2.18e-04	188	70	4	fa69f20ef6b8ce620ba342f0984d40ddf259bc3f
ToppCell	Epithelial-ciliated_cell\|World / Lineage, Cell type, age group and donor	ENKUR HYDIN CFAP99 CFAP65	2.18e-04	188	70	4	61a459f3fe57e5728efc72637ff2edc2d343492b
ToppCell	PBMC-Mild-Hematopoietic\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MPP1 ENKUR XIRP2 DMTN	2.18e-04	188	70	4	e3d9919eafc6181d2145b9d36f47066d0e22a8bd
ToppCell	droplet-Lung-1m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ENKUR SRCIN1 HYDIN CFAP65	2.18e-04	188	70	4	bc0b9ba8ae88e8a89e98b446584ed39606e4229e
ToppCell	PBMC-Mild-Hematopoietic\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MPP1 ENKUR XIRP2 DMTN	2.18e-04	188	70	4	6bd9317be8918da639254f4bdd432647c43ba9b1
ToppCell	droplet-Lung-1m-Epithelial-airway_epithelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ENKUR SRCIN1 HYDIN CFAP65	2.18e-04	188	70	4	50994e304c719f2f3c3232e48141e2dd15c96612
ToppCell	droplet-Lung-1m-Epithelial-airway_epithelial-lung_ciliated_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ENKUR SRCIN1 HYDIN CFAP65	2.18e-04	188	70	4	a7b7ba56603a8a50869b41902aed6a9ab1c5c021
ToppCell	droplet-Lung-21m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UBE2E2 MAP7D2 COL14A1 NDRG2	2.23e-04	189	70	4	cd42ce4aa217d0bd95e0cc0ba357bdfeb3e55a48
ToppCell	droplet-Lung-21m-Mesenchymal-myofibroblast-myofibroblast_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UBE2E2 MAP7D2 COL14A1 NDRG2	2.23e-04	189	70	4	102501eee7760d5882dec41ea9d00147b3f4fb73
ToppCell	mild_COVID-19-Platelet\|World / disease group, cell group and cell class (v2)	MPP1 ENKUR XIRP2 DMTN	2.23e-04	189	70	4	038ec3c266b89416bb5b774ba522d916394961da
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK4 FN1 COL14A1 CNTN1	2.23e-04	189	70	4	203c80030df08ae112f9ae4043709f455d87ce89
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PPARGC1A AKNA TANC1 MYO16	2.23e-04	189	70	4	78cf414b98bcb19deb934409acddaad1cd51b67f
ToppCell	droplet-Lung-21m-Mesenchymal-myofibroblast\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UBE2E2 MAP7D2 COL14A1 NDRG2	2.23e-04	189	70	4	6e83bf855d4771885b60bb8992df2f9b508eef97
ToppCell	PBMC-Mild-Hematopoietic-Platelet\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MPP1 ENKUR XIRP2 DMTN	2.27e-04	190	70	4	726aeb280ea911f3551b18e388c4f7580ae2ea74
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCBP3 COL14A1 REV3L MYO16	2.27e-04	190	70	4	45df8fee00f8949937863159d7aa042e72748d9b
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MPP1 ENKUR XIRP2 DMTN	2.27e-04	190	70	4	50ea3ff7ba1ca335b4e4538fae5f9b74b1fc10f7
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	MPP1 ENKUR XIRP2 DMTN	2.27e-04	190	70	4	a1f8757dc719ed030f67d65735358a8d7a407bad
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-C_(Myofibroblast)\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	DOCK4 FN1 COL14A1 CNTN1	2.27e-04	190	70	4	71e112dfb8c3190fe0286b45a046ea789eb6a8db
Computational	Genes in the cancer module 4.	UBE2K UBE2E1 UBE2V2	7.03e-05	21	42	3	MODULE_4
Computational	Genes in the cancer module 82.	UBE2K UBE2E1 UBE2V2	1.06e-04	24	42	3	MODULE_82
Computational	Ubiquitin ligases.	UBE2K UBE2E1 UBE2V2	3.05e-04	34	42	3	MODULE_278
Disease	seasonality measurement	TJP2 MYO16	3.50e-04	12	69	2	EFO_0006876
Disease	DEAFNESS, AUTOSOMAL RECESSIVE (disorder)	DMXL2 PTPRQ	4.13e-04	13	69	2	C1846647
Disease	Schizophrenia	DOCK4 PPARGC1A PTPRA LRP2 PLEKHA6 BRD1 MYO16 CFAP65	1.04e-03	883	69	8	C0036341
Disease	Sensorineural Hearing Loss (disorder)	DMXL2 LRP2	1.32e-03	23	69	2	C0018784
Disease	hemoglobin A1 measurement	RC3H2 PTPRA UBE2E2 UBE2V2 VPS13A MGA	1.36e-03	520	69	6	EFO_0007629

Protein segments in the cluster

Peptide	Gene	Start	Entry
KEYTVRFTFPDPPPL	ABCF1	606	Q8NE71
ALPEPKVRIVEYSPP	BRD1	116	O95696
KPEKPSVTYATYRGP	CRYBG3	221	Q68DQ2
NVRKPTPRKPESPYG	AKAP11	411	Q9UKA4
VKPYPAPQPVRTDVA	AMOTL1	346	Q8IY63
GPRPPRKEVATYFSK	CALHM1	331	Q8IU99
PPVPAERPSYKEKFI	DMXL2	2436	Q8TDJ6
PQKSSPFLTRVPVYP	RC3H2	576	Q9HBD1
PPIEKFYALDPSFPR	NSUN2	531	Q08J23
PPRIRKTPKLTFYRP	CFAP99	276	D6REC4
RFAYPIPHTTRPPKK	CASK	766	O14936
VVYPPPVDPKKLIDS	FAR1	166	Q8WVX9
KTTKPPYPGSPVKYR	MAP7D2	306	Q96T17
IKSPRSYTPKPNPVI	MGA	1206	Q8IWI9
LEPPFRPKVKSPRDY	PRKCD	616	Q05655
SFPKIPYSPVKATRA	MYO16	1631	Q9Y6X6
FNKTAVPVRYPPKDP	ARSJ	526	Q5FYB0
RPPKTKFFFTVIPQP	CFAP65	181	Q6ZU64
KPKETYPNERVCPFP	ZFPM1	281	Q8IX07
YPVTGPKKTYITDPV	LPP	346	Q93052
AKPKPPSRRDPTPTY	LRP2	4621	P98164
ATIPYRPKPASTPVI	PCBP3	206	P57721
APARPKTKPTPIYDA	PTPRQ	1786	Q9UMZ3
SQSPPKGVTIPYRPK	PCBP2	171	Q15366
KTVVPPPSKKPRYSE	PPARGC1A	321	Q9UBK2
PEPVKPFLFYRAKTG	IL36G	111	Q9NZH8
PPALFSIVSYPVKRP	HYDIN	2611	Q4G0P3
APPPPDRPIEKKSYS	CASC3	391	O15234
EPVRKESKTPPPYSV	DOCK4	1891	Q8N1I0
IKYEKPGSPPREVVP	FN1	2026	P02751
PPSSPVKGYRIVYKP	COL14A1	851	Q05707
KYSDPPVNFLPVPSR	DHX57	431	Q6P158
FIPLIPIPERTTKPY	CNTN1	226	Q12860
PIPERTTKPYPADIV	CNTN1	231	Q12860
VTPVEKYIKVFPSPP	C20orf85	76	Q9H1P6
KYIKVFPSPPVPQTT	C20orf85	81	Q9H1P6
PKVTYKAPVPTGEVY	CANX	56	P27824
PAPKRNKPTVYGVSP	ABL1	216	P00519
PRVRFPKDESYRPPK	AKNA	366	Q7Z591
KEGPRTPVPSKYIRF	COPG2	461	Q9UBF2
RFIPEVAVAYPKSKP	BPIFB6	296	Q8NFQ5
PPQPPRYISIFKATV	ENKUR	21	Q8TC29
EAKPYVPKEPPVLRV	MAN2A2	821	P49641
SSFEYVPPKPKPSRV	KIF4A	1016	O95239
SSFEYIPPKPKPSRV	KIF4B	1016	Q2VIQ3
VYPVPYTTRPPRKSE	MPP1	311	Q00013
PETSRPDSNIYKKPP	DMTN	131	Q08495
SPSTNRKYPPLPVDK	PTPRA	211	P18433
KFPYIPPESFLKPEA	RPGRIP1	926	Q96KN7
YTVVRKPKPSSFPDG	NHSL2	921	Q5HYW2
TFTVYGTPKPKRPAI	NDRG2	51	Q9UN36
PGPVRKPKYVESPRV	TANC1	86	Q9C0D5
KPKYVESPRVPGDAV	TANC1	91	Q9C0D5
SKPVVGIIYPPPEVR	SF3A1	36	Q15459
YKKRKRSPSPSPTPE	SMARCC2	296	Q8TAQ2
PYRPAKPVPTPKKGF	RIOK3	141	O14730
KKDSYVEPPPRRPMS	XIRP2	2971	A4UGR9
SPKVPPYPEVFRDSL	PLEKHA6	506	Q9Y2H5
STKGYPPPVAAKPTF	TJP2	1031	Q9UDY2
FPFVFYPVKPPKSVT	VPS13A	2661	Q96RL7
REAPKREAPAFPYPT	ZFHX2	1956	Q9C0A1
LDITFSPDYPFKPPK	UBE2E2	106	Q96LR5
SPDYPFKPPKVTFRT	UBE2E2	111	Q96LR5
KVPDSPATKYPIYPL	REV3L	1026	O60673
PATKYPIYPLTPKKS	REV3L	1031	O60673
TVPRYRTEKPSKSPP	SRCIN1	991	Q9C0H9
VPYTPKFPTPKPRKT	FGD6	306	Q6ZV73
SVITYTAPPRPPKKR	ZBTB4	506	Q9P1Z0
PLFPDTDYKPVPLKT	POLR3G	36	O15318
PYPSNKRLPEEVPSF	VILL	596	O15195
KIPETYPFNPPKVRF	UBE2K	61	P61086
PKYPEAPPSVRFVTK	UBE2V2	71	Q15819
TFTPEYPFKPPKVTF	UBE2E1	101	P51965
VKIPADPPFSAYPAV	VSIG10L2	691	P0DP72
PDFKPPADYKPPATR	SF1	121	Q15637
TSPVERYPGRPVKAK	KIAA1958	96	Q8N8K9