Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	-	ALAS2 GLDC	2.56e-03	39	36	2	3.40.640.10
Domain	PyrdxlP-dep_Trfase	ALAS2 GLDC	2.83e-03	41	36	2	IPR015424
Domain	PyrdxlP-dep_Trfase_major_sub1	ALAS2 GLDC	2.83e-03	41	36	2	IPR015421
Pubmed	HOXA5 induces M2 macrophage polarization to attenuate carotid atherosclerosis by activating MED1.	HOXA5 MED1	1.04e-06	2	36	2	34117711
Pubmed	Transcriptional analysis of brown adipose tissue in leptin-deficient mice lacking inducible nitric oxide synthase: evidence of the role of Med1 in energy balance.	MED1 NOS2	3.12e-06	3	36	2	22570438
Pubmed	DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures.	RELN DNMT1	3.12e-06	3	36	2	15671176
Pubmed	Reelin controls position of autonomic neurons in the spinal cord.	RELN NOS2	6.24e-06	4	36	2	10880573
Pubmed	RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus.	IPO5 MSI2	6.24e-06	4	36	2	25782991
Pubmed	Polymorphisms in genes involved in innate immunity predispose toward mycetoma susceptibility.	CR1 NOS2	1.04e-05	5	36	2	17709521
Pubmed	mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1.	TSC1 RELN	1.56e-05	6	36	2	30271915
Pubmed	Characterizing the new transcription regulator protein p60TRP.	IPO5 CRLF1	1.56e-05	6	36	2	15034937
Pubmed	DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients.	RELN DNMT1	1.56e-05	6	36	2	25476119
Pubmed	An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).	NOS2 SLC19A1 DNMT1	1.82e-05	49	36	3	19161160
Pubmed	Activation of the PI3K/AKT/mTOR Pathway in Cajal-Retzius Cells Leads to Their Survival and Increases Susceptibility to Kainate-Induced Seizures.	TSC1 RELN	2.18e-05	7	36	2	36982451
Pubmed	Location of preganglionic neurons is independent of birthdate but is correlated to reelin-producing cells in the spinal cord.	RELN NOS2	3.73e-05	9	36	2	15236237
Pubmed	Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis.	RELN MSI2	9.41e-05	14	36	2	15273690
Pubmed	Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.	CR1 NOS2	1.76e-04	19	36	2	20459687
Pubmed	Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling.	HOXA5 RELN	1.96e-04	20	36	2	20711475
Pubmed	Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development.	HOXA5 RELN	2.38e-04	22	36	2	25079229
Pubmed	Transcriptome analysis in blastocyst hatching by cDNA microarray.	PITRM1 DNMT1	3.08e-04	25	36	2	15919778
Pubmed	Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice.	NOS2 DNMT1	3.08e-04	25	36	2	12829028
Pubmed	Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.	IPO5 SLC19A1 ADGRA3	3.48e-04	132	36	3	26439863
Pubmed	Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon.	RELN MSI2	4.45e-04	30	36	2	21826226
Pubmed	A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities.	EHHADH NOS2	9.59e-04	44	36	2	20178365
Coexpression	GSE30083_SP1_VS_SP2_THYMOCYTE_DN	REC8 LZTR1 APPL2 CSNK1G3 B4GALT5	7.65e-06	200	36	5	M5024
ToppCell	3'_v3-blood-Mast-Mast_cells\|blood / Manually curated celltypes from each tissue	REC8 HOXA5 TTLL10 MSI2	1.21e-05	176	36	4	b9da3deaf62622d47eb30b6be7548253eee95597
ToppCell	droplet-Heart-nan-24m-Hematologic-red_blood_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALAS2 ZCCHC2 GLDC	1.27e-05	56	36	3	55337ff90621e1fea4d747ae2559c0fa61b38dce
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor-epi-stalk_early\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	REC8 CRLF1 FOXI3 GLDC	1.60e-05	189	36	4	a6c62b456982067ad4d224a2efa3919969000693
ToppCell	Globus_pallidus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Crym_(Crym)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	FMO4 GLDC VWDE	3.99e-05	82	36	3	bc4e309c0128d126c47895e88d2250324c6ff81a
ToppCell	Globus_pallidus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Crym_(Crym)--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	FMO4 GLDC VWDE	3.99e-05	82	36	3	9cd1b8a580566904a1ca0d4b5c48b2bf12a8898b
ToppCell	Globus_pallidus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Crym_(Crym)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	FMO4 GLDC VWDE	3.99e-05	82	36	3	0fb857a83f61d8c26be1b151903f4e6dc69397f9
Drug	S-Adenosylhomocysteine	ALAS2 SLC19A1 DNMT1	4.06e-06	20	36	3	ctd:D012435
Disease	malaria (is_implicated_in)	CR1 NOS2 SLC19A1	2.54e-06	24	33	3	DOID:12365 (is_implicated_in)
Disease	Autistic Disorder	TSC1 RELN LZTR1 NOS2 SLC19A1	1.01e-05	261	33	5	C0004352
Disease	–	CR1 NOS2	1.44e-04	16	33	2	611162
Disease	Malaria, susceptibility to	CR1 NOS2	1.44e-04	16	33	2	cv:C1970028
Disease	Malaria	CR1 NOS2	2.28e-04	20	33	2	C0024530
Disease	Colonic Neoplasms	NOS2 SLC19A1 DNMT1	6.53e-04	152	33	3	C0009375
Disease	Malignant tumor of colon	NOS2 SLC19A1 DNMT1	7.44e-04	159	33	3	C0007102
Disease	schizophrenia (is_marker_for)	RELN DNMT1	1.11e-03	44	33	2	DOID:5419 (is_marker_for)
Disease	childhood trauma measurement, smoking behaviour measurement	EHHADH SLC19A1	1.17e-03	45	33	2	EFO_0005671, EFO_0007979
Disease	Mouth Neoplasms	HOXA5 TSC1	1.67e-03	54	33	2	C0026640
Disease	Malignant neoplasm of mouth	HOXA5 TSC1	1.67e-03	54	33	2	C0153381
Disease	Seizures	TSC1 NOS2 GLDC	1.84e-03	218	33	3	C0036572
Disease	Alzheimer's disease (implicated_via_orthology)	PITRM1 NOS2	1.86e-03	57	33	2	DOID:10652 (implicated_via_orthology)
Disease	Bipolar Disorder	RELN ZCCHC2 EHHADH DNMT1	1.90e-03	477	33	4	C0005586
Disease	pyroglutamine measurement	RELN SLC6A20	1.93e-03	58	33	2	EFO_0005408

Protein segments in the cluster

Peptide	Gene	Start	Entry
CVQVYSMGGPNRFYF	DNMT1	1071	P26358
YGPASFITFVNCMYF	ADGRA3	921	Q8IWK6
YPYRTIGCVFNHQMF	CEP76	451	Q8TAP6
SDRNYYGCGQMPRHF	B4GALT5	241	O43286
GMLYAFPPCDFSQQY	RBM15B	851	Q8NDT2
MFYYPNVLQRHTGCF	REC8	1	O95072
MLGYPNFVATYGRGY	MSI2	216	Q96DH6
YAVFGLGSSMYPRFC	NOS2	621	P35228
MALYCGDNFGVYSQP	FOXI3	1	A8MTJ6
IRSGEMYRFQFSCYP	LZTR1	411	Q8N653
FLSIGYGDMVPNTYC	KCNN2	356	Q9H2S1
CFGFVGNRMLNPYYN	EHHADH	476	Q08426
MSSYFVNSFCGRYPN	HOXA5	1	P20719
VFFGPCTPYQYRLMG	FMO4	461	P31512
VMAQYGGDNYRPFCT	IPO5	931	O00410
QVYYFGPCGKYNAMV	CSNK1G3	101	Q9Y6M4
NMPGNYVFSYDQFFR	ALAS2	136	P22557
QFYFMYGCLITPNNR	RELN	2576	P78509
SMVHIYPCAFYGRGF	AWAT2	251	Q6E213
SLNYECRPGYFGKMF	CR1	1421	P17927
YFFTQGGNLMCQPRG	APPL2	301	Q8NEU8
FPTHYPAGFQVYCDM	FIBCD1	261	Q8N539
IFVCNYGPAGNFANM	GLIPR1L1	166	Q6UWM5
VYFVQVRCNPFGIYG	CRLF1	306	O75462
MRFYAALPGQQHCYF	MED1	361	Q15648
PFNRRFYQMTGQDFG	HS3ST6	326	Q96QI5
QYCAQPTNGMVYFRA	PITRM1	586	Q5JRX3
FPYLCQMYGGGSFLV	SLC6A20	31	Q9NP91
YGMQQMAGFGRFYPV	ZCCHC2	1096	Q9C0B9
AYTCYRPDVGYVQGM	TBC1D14	496	Q9P2M4
FSVYLLQPTQGCMGY	VWDE	141	Q8N2E2
LYGMYPCNFVSFLRS	TSC1	191	Q92574
PPQYGLYSAFMGCFV	SLC26A11	76	Q86WA9
YLCFYGFMAQIRPGE	SLC19A1	31	P41440
CTTPYMIFFGHGYAR	TTLL10	386	Q6ZVT0
RSYIGMGYYNCSVPQ	GLDC	131	P23378