Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	absent organized vascular network	CRELD1 PIEZO1	4.36e-05	8	18	2	MP:0000263
Domain	SMAD_FHA_domain	IRF6 APTX	2.02e-03	52	24	2	IPR008984
Pubmed	Haplotype-based gene-gene interaction of bone morphogenetic protein 4 and interferon regulatory factor 6 in the etiology of non-syndromic cleft lip with or without cleft palate in a Chilean population.	BMP4 IRF6	4.96e-07	2	25	2	28133786
Pubmed	Association of single nucleotide polymorphisms in AXIN2, BMP4, and IRF6 with Non-Syndromic Cleft Lip with or without Cleft Palate in a sample of the southeast Iranian population.	BMP4 IRF6	1.49e-06	3	25	2	29211286
Pubmed	Mutations in GATA4, NKX2.5, CRELD1, and BMP4 are infrequently found in patients with congenital cardiac septal defects.	CRELD1 BMP4	2.97e-06	4	25	2	18076106
Pubmed	Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate.	BMP4 IRF6	1.78e-05	9	25	2	20023658
Pubmed	Exploring the effects of gene dosage on mandible shape in mice as a model for studying the genetic basis of natural variation.	BMP4 IRF6	1.78e-05	9	25	2	23563729
Pubmed	Analysis of Zfhx1a mutant mice reveals palatal shelf contact-independent medial edge epithelial differentiation during palate fusion.	BMP4 IRF6	2.72e-05	11	25	2	18470539
Pubmed	Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch.	IRF6 DSC3	2.72e-05	11	25	2	17041603
Pubmed	Cell-autonomous and non-cell-autonomous roles for IRF6 during development of the tongue.	BMP4 IRF6	4.49e-05	14	25	2	23451037
Pubmed	IRF6 and AP2A Interaction Regulates Epidermal Development.	IRF6 DSC3	5.92e-05	16	25	2	29913133
Pubmed	Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate.	BMP4 IRF6	3.08e-04	36	25	2	20672350
Disease	Orofacial cleft	BMP4 IRF6	6.33e-06	5	24	2	cv:C3266076
Disease	Cleft Lip with or without Cleft Palate	BMP4 IRF6	6.33e-06	5	24	2	C0810364
Disease	Cleft palate with cleft lip	BMP4 IRF6	2.27e-05	9	24	2	C0158646
Disease	cleft lip (is_implicated_in)	BMP4 IRF6	6.61e-05	15	24	2	DOID:9296 (is_implicated_in)
Disease	Cleft upper lip	BMP4 IRF6	4.61e-04	39	24	2	C0008924
Disease	Cleft palate	IRF6 IARS1	1.52e-03	71	24	2	HP_0000175
Disease	chronic obstructive pulmonary disease	CCDC192 BMP4 KLHL7 PIEZO1	2.15e-03	688	24	4	EFO_0000341

Protein segments in the cluster

Peptide	Gene	Start	Entry
DPKMQVYKDEQVVVI	APTX	191	Q7Z2E3
VKCINGKMCYVQKQP	C3orf70	136	A6NLC5
KVVLKNYQEMVVEGC	BMP4	391	P12644
YKQMEGICVKEQIPE	CRELD1	336	Q96HD1
LDLVKCRMQVDPQKY	SLC25A3	86	Q00325
QIYCMKEGVKDVNIP	JAKMIP2	616	Q96AA8
TNCVKDENVKQIIPM	MTG1	111	Q9BT17
CVVQKPEEQYKVMLQ	PDZD4	6	Q76G19
KNEVNVPCLKNFVEM	FRYL	281	O94915
PCVISQEIMEKYNIK	CFHR2	206	P36980
ANQYQIEPVKKMCVD	KLHL7	121	Q8IXQ5
LCKYPDIVQQFKMQL	ICOS	41	Q9Y6W8
IENIKQVPQKLEQCM	EXOC4	131	Q96A65
EILQEYVVICKPKMG	DSC3	576	Q14574
VIMVKPYKLCNNQEE	C5orf22	156	Q49AR2
EVVFKPQKKCQEYEM	GK5	496	Q6ZS86
GPYEKMVLVKDQCIQ	CCDC192	126	P0DO97
KEVPMNPVKIYQVCD	IRF6	101	O14896
CIVPKMLVNIQTENK	OR7D2	76	Q96RA2
VCVNPEMQYVKIKDV	IARS1	236	P41252
LPRMYNQVKVKVTCA	ZNF618	526	Q5T7W0
LNFLQVPMCKEYEVK	TAS1R2	51	Q8TE23
YPEGQVKSQMKCVVL	WDR93	476	Q6P2C0
IVCKMLYQLKVVNPQ	PIEZO1	866	Q92508
DYQIVITRPQKQEMK	GLYATL2	51	Q8WU03