Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	carbohydrate binding	NOMO2 GUSB ENPP1 OGFOD2 PGLS C4A C4B NOMO3 NOMO1	9.99e-06	310	89	9	GO:0030246
GeneOntologyMolecularFunction	rRNA (cytosine-N4-)-methyltransferase activity	METTL15P1 METTL15	1.96e-05	2	89	2	GO:0071424
GeneOntologyMolecularFunction	rRNA (cytosine) methyltransferase activity	METTL15P1 METTL15	2.91e-04	6	89	2	GO:0016434
GeneOntologyBiologicalProcess	multi-pass transmembrane protein insertion into ER membrane	NOMO2 NOMO3 NOMO1	6.19e-06	9	88	3	GO:0160063
GeneOntologyCellularComponent	multi-pass translocon complex	NOMO2 NOMO3 NOMO1	6.58e-06	9	91	3	GO:0160064
GeneOntologyCellularComponent	ER membrane insertion complex	NOMO2 NOMO3 NOMO1	2.81e-05	14	91	3	GO:0072379
GeneOntologyCellularComponent	hippocampal mossy fiber	PDE2A TNN	3.88e-04	7	91	2	GO:0097457
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B	5.16e-04	8	91	2	GO:0106139
GeneOntologyCellularComponent	other organism part	C4A C4B	6.61e-04	9	91	2	GO:0044217
Domain	DUF2012	NOMO2 NOMO3 NOMO1	3.89e-07	4	87	3	PF09430
Domain	DUF2012	NOMO2 NOMO3 NOMO1	3.89e-07	4	87	3	IPR019008
Domain	Carb-bd-like_fold	NOMO2 NOMO3 NOMO1	5.38e-06	8	87	3	IPR013784
Domain	CarboxyPept_regulatory_dom	NOMO2 NOMO3 NOMO1	2.70e-05	13	87	3	IPR014766
Domain	-	NOMO2 NOMO3 NOMO1	2.70e-05	13	87	3	2.60.40.1120
Domain	CarboxyPept-like_regulatory	NOMO2 NOMO3 NOMO1	6.33e-05	17	87	3	IPR008969
Domain	GUANYLATE_KINASE_2	LRGUK TJP1 CARD11	1.62e-04	23	87	3	PS50052
Domain	GUANYLATE_KINASE_1	LRGUK TJP1 CARD11	1.62e-04	23	87	3	PS00856
Domain	Anaphylatoxin_comp_syst	C4A C4B	2.13e-04	5	87	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	2.13e-04	5	87	2	IPR001840
Domain	ANATO	C4A C4B	4.44e-04	7	87	2	SM00104
Domain	ANATO	C4A C4B	4.44e-04	7	87	2	PF01821
Domain	ANAPHYLATOXIN_2	C4A C4B	4.44e-04	7	87	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	4.44e-04	7	87	2	PS01177
Domain	Anaphylatoxin/fibulin	C4A C4B	4.44e-04	7	87	2	IPR000020
Domain	Thiol-ester_cl	C4A C4B	5.90e-04	8	87	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	5.90e-04	8	87	2	IPR019565
Domain	MacrogloblnA2_CS	C4A C4B	5.90e-04	8	87	2	IPR019742
Domain	A2M_N	C4A C4B	9.42e-04	10	87	2	PF01835
Domain	A2M_N	C4A C4B	9.42e-04	10	87	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	9.42e-04	10	87	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	9.42e-04	10	87	2	PS00477
Domain	A2M	C4A C4B	9.42e-04	10	87	2	PF00207
Domain	A2M_N_2	C4A C4B	9.42e-04	10	87	2	IPR011625
Domain	A2M_comp	C4A C4B	9.42e-04	10	87	2	IPR011626
Domain	A2M_N_2	C4A C4B	9.42e-04	10	87	2	PF07703
Domain	A2M_recep	C4A C4B	9.42e-04	10	87	2	PF07677
Domain	A2M_comp	C4A C4B	9.42e-04	10	87	2	PF07678
Domain	Macroglobln_a2	C4A C4B	9.42e-04	10	87	2	IPR001599
Domain	-	NRG1 NOMO2 TNN ICAM3 MMP23B KIRREL1 EXOC2 PTPRT NOMO3 NOMO1	1.01e-03	663	87	10	2.60.40.10
Domain	Ig-like_fold	NRG1 NOMO2 TNN ICAM3 MMP23B KIRREL1 EXOC2 PTPRT NOMO3 NOMO1	1.62e-03	706	87	10	IPR013783
Domain	C345C	C4A C4B	2.79e-03	17	87	2	SM00643
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	3.13e-03	18	87	2	IPR008930
Domain	NTR	C4A C4B	3.48e-03	19	87	2	PF01759
Domain	Fibrinogen_CS	ANGPTL6 TNN	3.48e-03	19	87	2	IPR020837
Domain	Netrin_module_non-TIMP	C4A C4B	3.48e-03	19	87	2	IPR018933
Domain	PDZ	SHROOM3 TJP1 CARD11 TAMALIN	5.07e-03	148	87	4	SM00228
Domain	NTR	C4A C4B	5.09e-03	23	87	2	PS50189
Domain	Netrin_domain	C4A C4B	5.09e-03	23	87	2	IPR001134
Domain	-	SHROOM3 TJP1 CARD11 TAMALIN	5.31e-03	150	87	4	2.30.42.10
Domain	PDZ	SHROOM3 TJP1 CARD11 TAMALIN	5.44e-03	151	87	4	PS50106
Domain	Fibrinogen_a/b/g_C_2	ANGPTL6 TNN	5.54e-03	24	87	2	IPR014715
Domain	-	ANGPTL6 TNN	5.54e-03	24	87	2	4.10.530.10
Domain	PDZ	SHROOM3 TJP1 CARD11 TAMALIN	5.56e-03	152	87	4	IPR001478
Domain	Guanylate_kin	LRGUK TJP1	6.48e-03	26	87	2	PF00625
Domain	GK/Ca_channel_bsu	LRGUK TJP1	6.48e-03	26	87	2	IPR008145
Domain	Guanylate_kin-like_dom	LRGUK TJP1	6.48e-03	26	87	2	IPR008144
Domain	TIMP-like_OB-fold	C4A C4B	6.48e-03	26	87	2	IPR008993
Domain	GuKc	LRGUK TJP1	6.48e-03	26	87	2	SM00072
Domain	Fibrinogen_C	ANGPTL6 TNN	6.98e-03	27	87	2	PF00147
Domain	FBG	ANGPTL6 TNN	8.03e-03	29	87	2	SM00186
Domain	-	ANGPTL6 TNN	8.57e-03	30	87	2	3.90.215.10
Domain	Fibrinogen_a/b/g_C_1	ANGPTL6 TNN	8.57e-03	30	87	2	IPR014716
Pubmed	Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.	NOMO2 NOMO3 NOMO1	1.73e-08	3	91	3	36011023
Pubmed	Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.	NOMO2 NOMO3 NOMO1	1.73e-08	3	91	3	25576386
Pubmed	Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.	NOMO2 NOMO3 NOMO1	6.92e-08	4	91	3	31833031
Pubmed	A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.	NOMO2 NOMO3 NOMO1	6.92e-08	4	91	3	9267806
Pubmed	Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.	NOMO2 NOMO3 NOMO1	9.61e-07	8	91	3	15257293
Pubmed	Hepatic lipase maturation: a partial proteome of interacting factors.	NOMO2 UGGT1 NOMO3 NOMO1	1.31e-06	31	91	4	19136429
Pubmed	Substrate-driven assembly of a translocon for multipass membrane proteins.	NOMO2 NOMO3 NOMO1	1.44e-06	9	91	3	36261522
Pubmed	An ER translocon for multi-pass membrane protein biogenesis.	NOMO2 NOMO3 NOMO1	2.82e-06	11	91	3	32820719
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	ANGPTL6 GUSB TNN SERPINF1 ICAM3 KERA C4A	5.29e-06	257	91	7	16335952
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	GSE1 SLC25A43 JMJD6 KLHL21 NT5DC2 SCN5A AMBRA1 XIAP SRPK2 POLDIP2 BRMS1L ANKRD52 PRRC2B	6.74e-06	1116	91	13	31753913
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	6.77e-06	2	91	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	6.77e-06	2	91	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	6.77e-06	2	91	2	15998580
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	6.77e-06	2	91	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	6.77e-06	2	91	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	6.77e-06	2	91	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	6.77e-06	2	91	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	6.77e-06	2	91	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	6.77e-06	2	91	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	6.77e-06	2	91	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	6.77e-06	2	91	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	6.77e-06	2	91	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	6.77e-06	2	91	2	12207352
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	6.77e-06	2	91	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	6.77e-06	2	91	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	6.77e-06	2	91	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	6.77e-06	2	91	2	22387014
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	6.77e-06	2	91	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	6.77e-06	2	91	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	6.77e-06	2	91	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	6.77e-06	2	91	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	6.77e-06	2	91	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	6.77e-06	2	91	2	23918728
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	6.77e-06	2	91	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	6.77e-06	2	91	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	6.77e-06	2	91	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	6.77e-06	2	91	2	4216347
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	6.77e-06	2	91	2	1699796
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	6.77e-06	2	91	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	6.77e-06	2	91	2	2997024
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	6.77e-06	2	91	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	6.77e-06	2	91	2	3624865
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	6.77e-06	2	91	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	6.77e-06	2	91	2	21857912
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	6.77e-06	2	91	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	6.77e-06	2	91	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	6.77e-06	2	91	2	4514997
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	6.77e-06	2	91	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	6.77e-06	2	91	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	6.77e-06	2	91	2	3167981
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	6.77e-06	2	91	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	6.77e-06	2	91	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	6.77e-06	2	91	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	6.77e-06	2	91	2	2302180
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	6.77e-06	2	91	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	6.77e-06	2	91	2	34358307
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	6.77e-06	2	91	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	6.77e-06	2	91	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	6.77e-06	2	91	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	6.77e-06	2	91	2	29080553
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	6.77e-06	2	91	2	26814963
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	6.77e-06	2	91	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	6.77e-06	2	91	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	6.77e-06	2	91	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	6.77e-06	2	91	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	6.77e-06	2	91	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	6.77e-06	2	91	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	6.77e-06	2	91	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	6.77e-06	2	91	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	6.77e-06	2	91	2	8132550
Pubmed	METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue.	METTL15P1 METTL15	6.77e-06	2	91	2	32573735
Pubmed	The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1.	TJP1 KIRREL1	6.77e-06	2	91	2	12578837
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	6.77e-06	2	91	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	6.77e-06	2	91	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	6.77e-06	2	91	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	6.77e-06	2	91	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	6.77e-06	2	91	2	16908004
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	6.77e-06	2	91	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	6.77e-06	2	91	2	7365238
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	6.77e-06	2	91	2	19150565
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	6.77e-06	2	91	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	6.77e-06	2	91	2	17506029
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	6.77e-06	2	91	2	17971360
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	6.77e-06	2	91	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	6.77e-06	2	91	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	6.77e-06	2	91	2	2993295
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	6.77e-06	2	91	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	6.77e-06	2	91	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	6.77e-06	2	91	2	6881182
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	6.77e-06	2	91	2	3944109
Pubmed	Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice.	METTL15P1 METTL15	6.77e-06	2	91	2	35682734
Pubmed	Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13).	ACSL6 ETV6	6.77e-06	2	91	2	10502316
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	6.77e-06	2	91	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	6.77e-06	2	91	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	6.77e-06	2	91	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	6.77e-06	2	91	2	35898513
Pubmed	Solution structure analysis of cytoplasmic domain of podocyte protein Neph1 using small/wide angle x-ray scattering (SWAXS).	TJP1 KIRREL1	6.77e-06	2	91	2	22262837
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	6.77e-06	2	91	2	33353966
Pubmed	Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).	C4A C4B	6.77e-06	2	91	2	3008092
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	6.77e-06	2	91	2	28873507
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	3.11e-04	9	54	2	1234
GeneFamily	PDZ domain containing	SHROOM3 TJP1 CARD11 TAMALIN	1.10e-03	152	54	4	1220
GeneFamily	Fibrinogen C domain containing	ANGPTL6 TNN	2.51e-03	25	54	2	554
GeneFamily	Immunoglobulin like domain containing	ICAM3 MMP23B KIRREL1 PTPRT	2.62e-03	193	54	4	594
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	TJP1 CARD11	2.72e-03	26	54	2	904
GeneFamily	Complement system\|Sushi domain containing	C4A C4B	5.17e-03	36	54	2	492
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	C4A C4B	5.45e-03	37	54	2	454
Coexpression	PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_UP	SHROOM3 NOMO2 RPN1 TJP1 GUSB ENPP1 DCLRE1B CLVS1 NOMO3 NOMO1	7.72e-08	297	90	10	MM1003
Coexpression	PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_UP	SHROOM3 RPN1 TJP1 GUSB ENPP1 DCLRE1B CLVS1 NOMO1	6.68e-06	287	90	8	M6510
Coexpression	NAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_CORRELATED_WITH_HAI_28DY_RESPONSE_AT_7DY_POSITIVE	MAN1A1 NOMO2 RPN1 UGGT1 NOMO3 NOMO1	2.06e-05	162	90	6	M41204
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ENPP1 TNN MMP23B ECRG4 KIRREL1 C4B	1.72e-06	177	91	6	6b4fe717928814dafcd13090b1c90ea973938c6d
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CSRNP3 ENPP1 LOXL1 SERPINF1 MMP23B PTGIS	1.90e-06	180	91	6	39ae8586efd91536e9ac6408d26de7e6d6237c41
ToppCell	facs-Lung-EPCAM-24m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B ECRG4 C4B PTGIS	2.09e-06	183	91	6	63294d66e3ccf152ffe5d1237106764c14390b62
ToppCell	facs-Lung-EPCAM-24m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B ECRG4 C4B PTGIS	2.09e-06	183	91	6	7e5c467fd1b156b928f1611a12ab4affb9f714b7
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SCN5A MMP23B PLEKHH2 PTGIS PGM5	2.22e-06	185	91	6	872720275789d249c9859de825a923803d458875
ToppCell	facs-Bladder-nan-24m-Epithelial-bladder_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B C4B PTGIS TAMALIN	2.37e-06	187	91	6	2c145e9d11424939dd99012a8cedf5d998b966e9
ToppCell	facs-Heart-RA-24m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL6 SHROOM3 SERPINF1 SCN5A MMP23B ECRG4	2.52e-06	189	91	6	e4efbb0733b382f4c855f6653dcddf36e0f8df28
ToppCell	(1)_Osterolineage_cells-(10)_OLC-1\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	GAMT NT5DC2 LOXL1 SERPINF1 MMP23B PTGIS	2.52e-06	189	91	6	46c5b975fb9d33017f2d9b7770d45a8bdf95baa2
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D231\|Adult / Lineage, Cell type, age group and donor	NRG1 SHROOM3 TJP1 CYP4B1 MMP23B CAV2	2.52e-06	189	91	6	5a04cb25f8f0447b2cecdb6c3695029281aca26d
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXC4 ENPP1 LOXL1 SERPINF1 MMP23B PTGIS	2.59e-06	190	91	6	8cb950effc449ae59a915132ecc079be54d1acfe
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXC4 ENPP1 LOXL1 SERPINF1 MMP23B PTGIS	2.59e-06	190	91	6	5dfbd064ab1f8a0b18b5975c47f8e79697f3db15
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXC4 ENPP1 LOXL1 SERPINF1 MMP23B PTGIS	2.59e-06	190	91	6	17a73a658fb30a4322b31e38db7b240023738f29
ToppCell	COPD-Endothelial-VE_Arterial\|Endothelial / Disease state, Lineage and Cell class	NOMO2 TJP1 MFHAS1 PTGIS NOMO3 NOMO1	2.67e-06	191	91	6	ef16ad1c1cd2c0c0377957398c98775b62a81754
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LOXL1 SERPINF1 MMP23B KIRREL1 C4B PTGIS	2.92e-06	194	91	6	5594f7437448cb4b37d2d100f44d30c4a367df26
ToppCell	droplet-Heart-HEART-1m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NT5DC2 LOXL1 SERPINF1 MMP23B ECRG4 PTGIS	3.10e-06	196	91	6	1eb14182ef26e6141f510d397b00bf8a12efda3e
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LOXL1 TNN SERPINF1 ECRG4 KERA PTGIS	3.19e-06	197	91	6	3fe665c0277d091290b63f0dd24c0c6536a45309
ToppCell	PCW_10-12\|World / Celltypes from embryonic and fetal-stage human lung	MMP23B ECRG4 CAV2 PLEKHH2 USP9Y PGM5	3.19e-06	197	91	6	47fd8b0d596c5db1a722473c8efbb17a6bbe7538
ToppCell	COVID_vent-Lymphocytic-Plasma_cell-IgA_Plasmablast\|COVID_vent / Disease condition, Lineage, Cell class and subclass	MAN1A1 NOMO2 RPN1 NT5DC2 NOMO3 NOMO1	3.19e-06	197	91	6	99fe44ef42c65d24fe64947fd5bf6d91b9a4b2c3
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	LOXL1 TNN SERPINF1 MMP23B NDST4 PLEKHH2	3.29e-06	198	91	6	300d7cc56207d77168390fa1ffcbcf76767b1b80
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B ECRG4 KERA PTGIS	3.29e-06	198	91	6	b086af292a508a156266c2d899ba1caf820bf61c
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B ECRG4 KERA PTGIS	3.29e-06	198	91	6	1b90d632e59c3c47b936e829cceeb0334f05f34f
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B KIRREL1 C4A	7.10e-06	130	91	5	e5acaa9aaa22b10d11410e2c01647b31354c21ed
ToppCell	Control-Plasmablast\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	MAN1A1 NOMO2 NT5DC2 SERPINF1 NOMO1	1.21e-05	145	91	5	fe68582f5a15b9714cb84fa32ac880e13cb69895
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IDO2 ENPP1 ECRG4 KIRREL1 SRPK3	2.06e-05	162	91	5	22f1abd20f43bc7e7fc46969da9962faf70ae5d2
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IDO2 ENPP1 ECRG4 KIRREL1 SRPK3	2.06e-05	162	91	5	966df4558140c3d541999ab553f201ae76a1c401
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A GSE1 HHIPL2 TAMALIN PGM5	2.06e-05	162	91	5	5428c9fdb816f564395ebb4520448e5f3a42b025
ToppCell	E15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NRG1 CYP4B1 CAV2 PTGIS PGM5	2.67e-05	171	91	5	3112d15f2a28cf4a71992db4971d960716dc1264
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	NRG1 SHROOM3 TJP1 CYP4B1 CAV2	2.90e-05	174	91	5	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SHROOM3 ENPP1 LOXL1 ST3GAL1 CAV2	2.98e-05	175	91	5	90e29945aa861082c94bb4f331161adc3a6ef899
ToppCell	AT1-AT2_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	NRG1 CYP4B1 NT5DC2 CAV2 PLEKHH2	2.98e-05	175	91	5	bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SHROOM3 ENPP1 LOXL1 ST3GAL1 CAV2	3.07e-05	176	91	5	e4b21fd6a5e0c5950f27c3e1868318e48330ae5e
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC25A43 GAMT MFHAS1 LOXL1 PTGIS	3.15e-05	177	91	5	4553ee8cd9c24db6511b09fe49ed11a89e7cde9e
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NRG1 SHROOM3 TJP1 CYP4B1 CAV2	3.32e-05	179	91	5	4f6ca313b78aa93557937a046c44dcf8bcc9963c
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXC4 LOXL1 SERPINF1 MMP23B PTGIS	3.50e-05	181	91	5	269b39ac65790061d54eab47a8eeb024403f0348
ToppCell	Severe-Lymphoid-pDC\|Severe / Condition, Lineage, Cell class and cell subclass	SERPINF1 MMP23B CARD11 USP9Y TAMALIN	3.50e-05	181	91	5	2caecb7c5dcdad46fd02b4ffb73cb613ce835187
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXC4 LOXL1 SERPINF1 MMP23B PTGIS	3.50e-05	181	91	5	cd4f744b6b64ba6c22ec07afd1d3058a2546909d
ToppCell	droplet-Liver-nan-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A CYP4B1 SRPK2 ANKRD52 PGM5	3.50e-05	181	91	5	fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXC4 LOXL1 SERPINF1 MMP23B PTGIS	3.50e-05	181	91	5	c8395ae872aa80b3ae1ab7c53e57b3ca15aeb0e2
ToppCell	Severe-Lymphoid-pDC-\|Severe / Condition, Lineage, Cell class and cell subclass	SERPINF1 MMP23B CARD11 USP9Y TAMALIN	3.50e-05	181	91	5	277ce4c49121da0990a5933b19d2c6af9bbe253e
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SERPINF1 NDST4 KERA PLEKHH2 PTGIS	3.60e-05	182	91	5	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NRG1 LOXL1 SERPINF1 MMP23B ECRG4	3.79e-05	184	91	5	01257e5c12e38b849fd3d9496c43ded666249ba5
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ENPP1 LOXL1 SERPINF1 ECRG4 PTGIS	3.79e-05	184	91	5	235890e8b424f4386b6ea52d173d20a00898df73
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NRG1 SHROOM3 TJP1 CYP4B1 CAV2	3.79e-05	184	91	5	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SHROOM3 LOXL1 ECRG4 PTGIS PGM5	3.79e-05	184	91	5	e33e2a887aafba7b6a31f00bb0dbe974b4359fd6
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D122\|Adult / Lineage, Cell type, age group and donor	NRG1 SHROOM3 TJP1 CYP4B1 CAV2	3.79e-05	184	91	5	561592edc3083fad41b91811151b442207c65dd9
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NRG1 SHROOM3 TJP1 CYP4B1 CAV2	3.79e-05	184	91	5	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	droplet-Kidney-nan-21m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXC4 LOXL1 SERPINF1 MMP23B PTGIS	3.89e-05	185	91	5	33cc0e9d8b54cb7408b51235f2a70e044ebae04d
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NRG1 SHROOM3 TJP1 CYP4B1 CAV2	3.89e-05	185	91	5	1c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ANGPTL6 SERPINF1 KERA SRPK3 PTGIS	3.89e-05	185	91	5	7dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCell	droplet-Fat-Mat-18m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A CYP4B1 HHIPL2 ZBTB3 PGM5	3.89e-05	185	91	5	d9be5853acdda7b1ac819cf50c7940d1d2362d15
ToppCell	E17.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LOXL1 ECRG4 NDST4 PTGIS PGM5	3.89e-05	185	91	5	c85bba1210f1d389add3e40be9b96abac40cf8c1
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Dendritic\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ENPP1 SERPINF1 OGFOD2 ETV6 TAMALIN	3.89e-05	185	91	5	405bd4ba7ca7f7b625c49f1313ff946509e17c13
ToppCell	droplet-Kidney-nan-21m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXC4 LOXL1 SERPINF1 MMP23B PTGIS	3.89e-05	185	91	5	9954fc85b183c1cc45c3c24e3dadc7984ee6f649
ToppCell	facs-Thymus-Epithelium-24m-Mesenchymal-fibroblast\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B C4B PTGIS	3.89e-05	185	91	5	eaa54b76743628c89b4310be57b87fa92b75fd37
ToppCell	facs-Thymus-Epithelium-24m-Mesenchymal-fibroblast\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B C4B PTGIS	3.89e-05	185	91	5	f7f4c921d248c637351e2e882589b99ba7f04b66
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Dendritic-conventional_dendritic_cell\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ENPP1 SERPINF1 OGFOD2 ETV6 TAMALIN	3.89e-05	185	91	5	2aa5e9f6f167d27317a01d22392b59512333fa64
ToppCell	facs-Thymus-Epithelium-24m-Mesenchymal\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B C4B PTGIS	3.89e-05	185	91	5	ff38a15af3dec36d9993f06623591872b5d1da9a
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CCDC168\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NRG1 PLEKHH2 CSMD2 PTGIS PTPRT	3.89e-05	185	91	5	5a0340c25196453f19e424d346efbf66d2c53ac3
ToppCell	P03-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NRG1 LOXL1 SERPINF1 MMP23B ECRG4	3.99e-05	186	91	5	c0a036096c2cb23305605b8aaf18869d6e0fb512
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LOXL1 TNN SERPINF1 PTGIS PTPRT	3.99e-05	186	91	5	4e983de6d2515082f9e555f4f949cec84281c140
ToppCell	normal_Lung-Myeloid_cells-CD141+_DCs\|normal_Lung / Location, Cell class and cell subclass	IDO2 ENPP1 SERPINF1 ICAM3 ETV6	3.99e-05	186	91	5	a6698a2f4edd81b67e06531ede0e207dd0309205
ToppCell	Epithelial-alveolar_epithelial_cell_type_1\|World / Lineage, Cell type, age group and donor	NRG1 SHROOM3 TJP1 CYP4B1 CAV2	3.99e-05	186	91	5	09d95daa3387a4814cffaa4b798cc2810c3759d0
ToppCell	facs-Heart-LA-24m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B C4B PTGIS	3.99e-05	186	91	5	ed0a91f47e77fe21d4c7678d0f2a7c5f97d63dda
ToppCell	facs-Skin-Anagen-24m-Mesenchymal\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SERPINF1 MMP23B ECRG4 C4B TAMALIN	4.09e-05	187	91	5	908df5520142d65fe32a003d26be14965082a1ea
ToppCell	facs-Trachea-nan-24m-Mesenchymal\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B C4B PTGIS	4.09e-05	187	91	5	71385068e3fd0bfa7822ae176113a49460c8636b
ToppCell	facs-Skin-Anagen-24m-Mesenchymal-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SERPINF1 MMP23B ECRG4 C4B TAMALIN	4.09e-05	187	91	5	c1dfab0b0d7f519b9f13f4e0365ab41c4b2ae1ec
ToppCell	facs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B C4B PTGIS	4.09e-05	187	91	5	f3ef3f5a761f8306edc39bf16e76e44aae6fa7f6
ToppCell	facs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B C4B PTGIS	4.09e-05	187	91	5	1669df899b1759c338ffce196fe009840123cfcd
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXC4 LOXL1 SERPINF1 KIRREL1 PTGIS	4.09e-05	187	91	5	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXC4 LOXL1 SERPINF1 KIRREL1 PTGIS	4.09e-05	187	91	5	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	facs-Trachea-nan-24m-Mesenchymal-fibroblast\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B C4B PTGIS	4.09e-05	187	91	5	b930d5f7d410ac1f340babec5c937388f64cafc0
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NRG1 SHROOM3 TJP1 CYP4B1 CAV2	4.09e-05	187	91	5	d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXC4 LOXL1 SERPINF1 KIRREL1 PTGIS	4.09e-05	187	91	5	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	facs-Skin-Anagen-24m-Mesenchymal-fibroblast\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SERPINF1 MMP23B ECRG4 C4B TAMALIN	4.09e-05	187	91	5	b486cc5ac678051fea9d4c7db53b26a5a8427e60
ToppCell	facs-Trachea-nan-24m-Mesenchymal-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B C4B PTGIS	4.09e-05	187	91	5	e891e571f6bb9433a0046215de6cabd89ed1effc
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1\|Adult / Lineage, Cell type, age group and donor	NRG1 SHROOM3 TJP1 CYP4B1 CAV2	4.09e-05	187	91	5	77f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A TJP1 CYP4B1 CAV2 PGM5	4.20e-05	188	91	5	0aa8747c2931b0c91f6d78bb2db8fd8ede6dd559
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	LOXL1 TNN MMP23B KERA TAMALIN	4.20e-05	188	91	5	c90669b51e1902fe7726555290c91c92a911df83
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-conventional_dendritic_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IDO2 ENPP1 SERPINF1 ICAM3 ETV6	4.20e-05	188	91	5	c39083b8020ae507246959abbb299d78bcd14042
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IDO2 ENPP1 SERPINF1 ICAM3 ETV6	4.20e-05	188	91	5	6e7a678474715f035cc13a0e226a937688f54121
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)-DC1_L.1.2.1.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IDO2 ENPP1 SERPINF1 ICAM3 ETV6	4.20e-05	188	91	5	8862ecb87fc9b95eccc527387f2332dcc92cfdc3
ToppCell	droplet-Pancreas-PANCREAS-30m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B ECRG4 PTGIS	4.31e-05	189	91	5	1821ae4a6e37ee4c6308071883f3f447a7c53c53
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 MMP23B C4B PLEKHH2 PTGIS	4.31e-05	189	91	5	544d95df910f1b276995624509a7e41b219baca0
ToppCell	droplet-Pancreas-PANCREAS-30m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B ECRG4 PTGIS	4.31e-05	189	91	5	1e4d7e8dc98b3d70351e6a6c2aaf9ca01f141b8f
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AFAP1 LOXL1 SERPINF1 MMP23B PLEKHH2	4.31e-05	189	91	5	a153b83314cf52808f685296cff8c95af3f4983d
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AFAP1 SERPINF1 MMP23B PLEKHH2 PGM5	4.31e-05	189	91	5	e9d5e858e320c6e9913c1ea6a54967d21eda605f
ToppCell	facs-Heart-RA-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B ECRG4 C4B	4.31e-05	189	91	5	7c6d586f352d0d44c24079e76272cb3a545441b5
ToppCell	droplet-Pancreas-PANCREAS-30m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B ECRG4 PTGIS	4.31e-05	189	91	5	1dc415ed41815f4296dafd8cf7f3e014c44db1db
ToppCell	facs-Heart-RA-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B ECRG4 C4B	4.31e-05	189	91	5	5438baaa3056fec46d59f75f03f27a93601936c1
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A TJP1 CYP4B1 CAV2 PGM5	4.41e-05	190	91	5	a08c5929b05a4969852e351a93c4e4deb4c8d5b6
ToppCell	MatrixFB-Fibroblast-C\|MatrixFB / shred on cell class and cell subclass (v4)	LOXL1 SERPINF1 MMP23B ECRG4 ST3GAL1	4.41e-05	190	91	5	d0106f7a21292f0b96ce4337ec3efbb1bd78dd0a
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal-mesenchymal_stem_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B C4B PTGIS	4.41e-05	190	91	5	d13fd234caa3fc69d8a59bc0060cdacdf716ee55
ToppCell	Control-Endothelial-VE_Venous\|Endothelial / Disease state, Lineage and Cell class	NRG1 AFAP1 GSE1 MFHAS1 PTGIS	4.41e-05	190	91	5	4e30155203b4a8c5e496fcbe9348b67b98ebc625
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A TJP1 CYP4B1 CAV2 PGM5	4.41e-05	190	91	5	25525fee1da8a808034d9c916159fd0b6b26bce8
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B C4B PTGIS	4.41e-05	190	91	5	97772e69e6f51ebffbb5433ca7b40f1048723220
ToppCell	facs-GAT-Fat-24m-Mesenchymal\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B C4B PTGIS	4.41e-05	190	91	5	3720e64129f3f3268b1dc14031a76f41c38241c2
ToppCell	facs-GAT-Fat-24m-Mesenchymal-mesenchymal_progenitor\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B C4B PTGIS	4.41e-05	190	91	5	73a50426f972f08f9bb525ad5c0b774187ab5d6a
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	GSE1 CAV2 PLEKHH2 USP9Y PGM5	4.41e-05	190	91	5	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	facs-GAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B C4B PTGIS	4.41e-05	190	91	5	b55cf1fb586b724295b7b038483249847bb344fc
ToppCell	droplet-Lung-nan-18m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL1 SERPINF1 MMP23B C4B PTGIS	4.41e-05	190	91	5	72c2b824acdc43139e6635785df3ed3feb58ec46
Disease	Antiglaucoma preparations and miotics use measurement	AFAP1 LOXL1 EXOC2	5.92e-05	26	86	3	EFO_0009944
Disease	Autosomal Recessive Polycystic Kidney Disease	NPHP3 IFT88	2.98e-04	9	86	2	C0085548
Disease	alopecia areata	GSE1 EXOC2 PLEKHH2	4.24e-04	50	86	3	EFO_0004192
Disease	smoking behavior, BMI-adjusted waist circumference	HOXC4 NT5DC2 LOXL1 SRPK2	4.55e-04	122	86	4	EFO_0004318, EFO_0007789
Disease	leukemia (is_implicated_in)	ACSL6 ETV6	6.41e-04	13	86	2	DOID:1240 (is_implicated_in)
Disease	autosomal dominant polycystic kidney disease (implicated_via_orthology)	NPHP3 IFT88	7.47e-04	14	86	2	DOID:898 (implicated_via_orthology)
Disease	glaucoma	AFAP1 LOXL1 EXOC2 CAV2	1.09e-03	154	86	4	MONDO_0005041
Disease	primary open angle glaucoma (is_implicated_in)	LOXL1 CAV2	2.04e-03	23	86	2	DOID:1070 (is_implicated_in)
Disease	supramarginal gyrus volume measurement	MFHAS1 PRORP	2.22e-03	24	86	2	EFO_0010332
Disease	response to antiviral drug, cirrhosis of liver	MAN1A1 NDST4	2.22e-03	24	86	2	EFO_0001422, EFO_0010123
Disease	open-angle glaucoma	AFAP1 LOXL1 EXOC2 CAV2	2.39e-03	191	86	4	EFO_0004190

Protein segments in the cluster

Peptide	Gene	Start	Entry
SYSGDALYELFHDPS	AMER3	416	Q8N944
HSSRYPSPAELDAYA	FAM222A	36	Q5U5X8
SYGQDYDLSPSRSHT	CDK12	241	Q9NYV4
RHYDEDSAIGPRSPY	ECRG4	121	Q9H1Z8
YDFLHIYDGRDSLSP	CSMD2	1496	Q7Z408
ATYDLEGHPQYLLDS	C4B	1691	P0C0L5
RLVPFDHAESTYGLY	PGLS	81	O95336
GSSTDPEALHYDYID	AFAP1	441	Q8N556
EDYLRSFRPYHTTDD	GSE1	216	Q14687
LSRYDGAGSREHPIY	AMBRA1	701	Q9C0C7
SPLHYAAASDTYRRA	ANKRD52	491	Q8NB46
IPYSDHSSYSELRAF	DCLRE1B	271	Q9H816
RDDDSGPYNYSSLLA	ATP10D	21	Q9P241
SSLDYRRLPDAHSDY	RBM14	631	Q96PK6
PGEDESLEELSHYYA	PYY3	36	Q5JQD4
GAYSVGPLHSDLEYT	NOMO3	836	P69849
TPDSYRDSPHSERYV	NRG1	411	Q02297
LYAESYERDPSGHDQ	PGM5	521	Q15124
SAYESLGLRPRHAYS	CAPN15	706	O75808
HDDSRALYAIPGLDY	POLDIP2	161	Q9Y2S7
ALYAIPGLDYVSHED	POLDIP2	166	Q9Y2S7
DFRYRSPHSGDVLYE	ETV6	101	P41212
GAYSVGPLHSDLEYT	NOMO2	836	Q5JPE7
ASSYHPARPEVYDSL	OGFOD2	86	Q6N063
DDSPLYIFDSSYGEH	JMJD6	126	Q6NYC1
CHEELYSSRPYGALD	LRCH3	296	Q96II8
LRSASPHAAYYGVSD	MFHAS1	586	Q9Y4C4
PPDGLDRRYSHSLYS	LOXL1	266	Q08397
ARQAEEAYGASHYPA	CSRNP3	481	Q8WYN3
PLSLESYHISEEYGF	IDO2	26	Q6ZQW0
SYHISEEYGFLLPDS	IDO2	31	Q6ZQW0
YIRYLSDLHASGDPA	EXOC2	356	Q96KP1
LGSSPRLFLYHYSDS	IGLV11-55	61	A0A075B6I3
AYAHPLFYRGVDDST	PDE2A	481	O00408
GAYSVGPLHSDLEYT	NOMO1	836	Q15155
HFYTLYLEEPDSSGH	ENPP1	366	P22413
APLTSGLHYYTTLEE	LRGUK	696	Q96M69
YALDRDPTAYALAEH	METTL15P1	116	P0C7V9
EDEYTPLHRAAYSGH	ANKRD49	106	Q8WVL7
DPESRTFLSNYYRDH	NDST4	831	Q9H3R1
YALDRDPTAYALAEH	METTL15	116	A6NJ78
DYHPAELYRALAVSG	TAMALIN	61	Q7Z6J2
EDYEASGRSLLSTHY	PLEKHH2	871	Q8IVE3
SGSYHVREESTYLPL	ICAM3	516	P32942
HYYFSSRDRSSPGAL	PTPRT	106	O14522
HLAPETDEDDLYSGY	IFT88	6	Q13099
AREYHSSSVLDGLLY	KLHL21	371	Q9UJP4
LGANAFRTSHYPYAE	GUSB	376	P08236
EHSPEYYGRTRESGF	HOXC4	31	P09017
YDGFSLEPESDHYRL	ANGPTL6	361	Q8NI99
SGLRDVYLLHESYDD	MAN1A1	586	P33908
DGHFDGILYDTYPLS	GAMT	126	Q14353
HEDRPSSRAVLYADY	KIRREL1	611	Q96J84
LHSARSEEGRLYYDG	BRMS1L	251	Q5PSV4
DTGLGHRDSSYYLAV	CYP4B1	201	P13584
ASLDDVLPIYAYGHA	HHIPL2	481	Q6UWX4
DDSYSHHSGLEYADP	CAV2	16	P51636
LDDDSHERYSFGPSS	CARD11	601	Q9BXL7
ATYDLEGHPQYLLDS	C4A	1691	P0C0L4
HLRDESGNSYSPEEY	NFE2	336	Q16621
DLEYDPLSNYSARHL	REXO1	231	Q8N1G1
LEFSYPGYLALGEAH	MMP23B	341	O75900
ENAYGADHPYTAREL	NPHP3	1016	Q7Z494
GRYVTVLLDPHSYDA	PTGIS	71	Q16647
AERDSFSYGPHLRYL	KERA	311	O60938
RAPDELHYTYLDTFG	RPN1	391	P04843
RGSDYSHSEDLADFP	SCN5A	1991	Q14524
LRESSYGPEIDSHDF	ST3GAL1	151	Q11201
DLSNYDHAYLRRSPD	SHROOM3	201	Q8TF72
EPSYRGLLHAFSTIY	SLC25A43	141	Q8WUT9
SEDDPFLLYATLHSG	PRORP	476	O15091
TAIEYSHSHDRYLPG	SCMH1	476	Q96GD3
EYSDLEEAPSAHTLY	SLFNL1	36	Q499Z3
YLFEPHSGEDYSRDE	SRPK3	461	Q9UPE1
GSGPQLLTHYYDDAR	ACSL6	76	Q9UKU0
TLLGPDYSDENDYTH	CLVS1	286	Q8IUQ0
YAHLTPRELASAGLY	XIAP	176	P98170
RALYYDLISSPDIHG	SERPINF1	106	P36955
RSPDAHSGDHYTEAY	RBMXL3	876	Q8N7X1
YQGSLPDAYSGDHDR	RBMXL3	986	Q8N7X1
PDAYSGDHDRSSNSY	RBMXL3	991	Q8N7X1
SGLYTIYLHGDASRP	TNN	1081	Q9UQP3
SGPDYDFARYRSTVH	REX1BD	91	Q96EN9
YRSLYGDLDSALSAE	SOGA1	181	O94964
DYLFEPHSGEDYSRD	SRPK2	581	P78362
LDYPDHARSASDYRP	TMEM79	376	Q9BSE2
TDRDYVPDSYRHPDA	PRRC2B	1251	Q5JSZ5
RIYTLGHLHDSYPTD	SPRED2	176	Q7Z698
NSIRLYAGDHEDYDP	USP9Y	626	O00507
PRVLYFGDHLYSDLA	NT5DC2	351	Q9H857
HDDRLSYLSAPGSEY	TJP1	816	Q07157
LSSYDSDRSYPLDLE	FTSJ1	241	Q9UET6
SDRSYPLDLEGGSEY	FTSJ1	246	Q9UET6
YRIYSHDGTDSPPDA	UGGT1	1176	Q9NYU2
AYSYSASPQRDLDHR	TMEM39B	476	Q9GZU3
SLHEPLYLSSEYEAA	ZBTB3	446	Q9H5J0
YAEADDERLYSGEPH	NACAD	396	O15069